39 results on '"Nicole, Harris"'
Search Results
2. The spatial and temporal distribution of SARS-CoV-2 from the built environment of COVID-19 patient rooms: A multicentre prospective study.
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Michael Fralick, Madison Burella, Aaron Hinz, Hebah S Mejbel, David S Guttman, Lydia Xing, Jason Moggridge, John Lapp, Alex Wong, Caroline Nott, Nicole Harris-Linton, Rees Kassen, and Derek R MacFadden
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Medicine ,Science - Abstract
BackgroundSARS-CoV-2 can be detected from the built environment (e.g., floors), but it is unknown how the viral burden surrounding an infected patient changes over space and time. Characterizing these data can help advance our understanding and interpretation of surface swabs from the built environment.MethodsWe conducted a prospective study at two hospitals in Ontario, Canada between January 19, 2022 and February 11, 2022. We performed serial floor sampling for SARS-CoV-2 in rooms of patients newly hospitalized with COVID-19 in the past 48 hours. We sampled the floor twice daily until the occupant moved to another room, was discharged, or 96 hours had elapsed. Floor sampling locations included 1 metre (m) from the hospital bed, 2 m from the hospital bed, and at the room's threshold to the hallway (typically 3 to 5 m from the hospital bed). The samples were analyzed for the presence of SARS-CoV-2 using quantitative reverse transcriptase polymerase chain reaction (RT-qPCR). We calculated the sensitivity of detecting SARS-CoV-2 in a patient with COVID-19, and we evaluated how the percentage of positive swabs and the cycle threshold of the swabs changed over time. We also compared the cycle threshold between the two hospitals.ResultsOver the 6-week study period we collected 164 floor swabs from the rooms of 13 patients. The overall percentage of swabs positive for SARS-CoV-2 was 93% and the median cycle threshold was 33.4 (interquartile range [IQR]: 30.8, 37.2). On day 0 of swabbing the percentage of swabs positive for SARS-CoV-2 was 88% and the median cycle threshold was 33.6 (IQR: 31.8, 38.2) compared to swabs performed on day 2 or later where the percentage of swabs positive for SARS-CoV-2 was 98% and the cycle threshold was 33.2 (IQR: 30.6, 35.6). We found that viral detection did not change with increasing time (since the first sample collection) over the sampling period, Odds Ratio (OR) 1.65 per day (95% CI 0.68, 4.02; p = 0.27). Similarly, viral detection did not change with increasing distance from the patient's bed (1 m, 2 m, or 3 m), OR 0.85 per metre (95% CI 0.38, 1.88; p = 0.69). The cycle threshold was lower (i.e., more virus) in The Ottawa Hospital (median quantification cycle [Cq] 30.8) where floors were cleaned once daily compared to the Toronto hospital (median Cq 37.2) where floors were cleaned twice daily.ConclusionsWe were able to detect SARS-CoV-2 on the floors in rooms of patients with COVID-19. The viral burden did not vary over time or by distance from the patient's bed. These results suggest floor swabbing for the detection of SARS-CoV-2 in a built environment such as a hospital room is both accurate and robust to variation in sampling location and duration of occupancy.
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- 2023
- Full Text
- View/download PDF
3. Cannabinoid use and effects in patients with epidermolysis bullosa: an international cross-sectional survey study
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Nicholas H. B. Schräder, Emily S. Gorell, Roy E. Stewart, José C. Duipmans, Nicole Harris, Victoria A. Perez, Jean Y. Tang, André P. Wolff, and Marieke C. Bolling
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Epidermolysis bullosa ,Cannabinoid-based medicines ,Symptom alleviation ,Patient driven research ,Genodermatoses ,Survey ,Medicine - Abstract
Abstract Background Epidermolysis bullosa (EB) patient anecdotes and case reports indicate that cannabinoid-based medicines (CBMs) may alleviate pain and pruritus and improve wound healing. CBM use has not been characterized in the EB patient population. Objectives To evaluate CBM use among EB patients, including CBM types, effects on symptoms (e.g., pain and pruritus), disease process (e.g., blistering, wounds, and inflammation), well-being (e.g., sleep, appetite) and concomitant medications. Methods English-speaking EB patients or caregivers completed an online international, anonymous, cross-sectional survey regarding CBM use. Respondents reported the types of CBMs, subsequent effects including perceived EB symptom alteration, changes in medication use, and side effects. Results Seventy-one EB patients from five continents reported using or having used CBMs to treat their EB. Missing question responses ranged between 0 (0%) and 33 (46%). Most used more than one CBM preparation (mean: 2.4 ± 1.5) and route of administration (mean: 2.1 ± 1.1). Topical and ingested were the most common routes. Pain and pruritus were reported retrospectively to decrease by 3 points (scale: 0–10; p
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- 2021
- Full Text
- View/download PDF
4. A multidisciplinary approach and consensus statement to establish standards of care for Angelman syndrome
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Jessica Duis, Mark Nespeca, Jane Summers, Lynne Bird, Karen G.C.B. Bindels‐de Heus, M. J. Valstar, Marie‐Claire Y. deWit, C. Navis, Maartje ten Hooven‐Radstaake, Bianca M. vanIperen‐Kolk, Susan Ernst, Melina Dendrinos, Terry Katz, Gloria Diaz‐Medina, Akshat Katyayan, Srishti Nangia, Ronald Thibert, Daniel Glaze, Christopher Keary, Karine Pelc, Nicole Simon, Anjali Sadhwani, Helen Heussler, Anne Wheeler, Caroline Woeber, Margaret DeRamus, Amy Thomas, Emily Kertcher, Lauren DeValk, Kristen Kalemeris, Kara Arps, Carol Baym, Nicole Harris, John P. Gorham, Brenda L. Bohnsack, Reid C. Chambers, Sarah Harris, Henry G. Chambers, Katherine Okoniewski, Elizabeth R. Jalazo, Allyson Berent, Carlos A. Bacino, Charles Williams, and Anne Anderson
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Angelman Syndrome ,genetics ,management ,neurogenetics ,UBE3A ,Genetics ,QH426-470 - Abstract
Abstract Background Angelman syndrome (AS) is a rare neurogenetic disorder present in approximately 1/12,000 individuals and characterized by developmental delay, cognitive impairment, motor dysfunction, seizures, gastrointestinal concerns, and abnormal electroencephalographic background. AS is caused by absent expression of the paternally imprinted gene UBE3A in the central nervous system. Disparities in the management of AS are a major problem in preparing for precision therapies and occur even in patients with access to experts and recognized clinics. AS patients receive care based on collective provider experience due to limited evidence‐based literature. We present a consensus statement and comprehensive literature review that proposes a standard of care practices for the management of AS at a critical time when therapeutics to alter the natural history of the disease are on the horizon. Methods We compiled the key recognized clinical features of AS based on consensus from a team of specialists managing patients with AS. Working groups were established to address each focus area with committees comprised of providers who manage >5 individuals. Committees developed management guidelines for their area of expertise. These were compiled into a final document to provide a framework for standardizing management. Evidence from the medical literature was also comprehensively reviewed. Results Areas covered by working groups in the consensus document include genetics, developmental medicine, psychology, general health concerns, neurology (including movement disorders), sleep, psychiatry, orthopedics, ophthalmology, communication, early intervention and therapies, and caregiver health. Working groups created frameworks, including flowcharts and tables, to help with quick access for providers. Data from the literature were incorporated to ensure providers had review of experiential versus evidence‐based care guidelines. Conclusion Standards of care in the management of AS are keys to ensure optimal care at a critical time when new disease‐modifying therapies are emerging. This document is a framework for providers of all familiarity levels.
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- 2022
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5. BOugie or stylet in patients UnderGoing Intubation Emergently (BOUGIE): protocol and statistical analysis plan for a randomised clinical trial
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Tamer Hudali, Megan Moore, Robert Mitchell, Wesley H Self, Todd W Rice, Matthew W Semler, Kate O’Connor, Christopher Hughes, Swati Gulati, Jonathan D Casey, Derek W Russell, Derek J Vonderhaar, William S Stigler, John Whittle, Jason R West, Kevin W Gibbs, Janna S Landsperger, Sarah W Robison, Itay Bentov, Matthew E Prekker, Christopher John Lindsell, David Janz, John P Gaillard, Bradley Lloyd, Sheetal Gandotra, Anna Altz-Stamm, Cristina Bardita, Mary Clay Boone, Joe W Chiles, Kristina Collins, Abby Drescher, Kevin G Dsouza, Janna Dunn, Stacy Ejem, Josh Gautney, Nicole Harris, Savannah Herder, R Chad Wade, Rutwij Joshi, Daniel Kelmenson, Anne Merrill Mason, Scott R Merriman, Takudzwa Mkorombindo, Jada Nowak, Lisa Sarratt, Tabitha Stewart, Kadambari Vijaykumar, Gina White, Micah R Whitson, Christopher Barnes, Andrew M Walters, Adit A Ginde, Brian Driver, Stacy A Trent, Lane M Smith, AM Joffe, Michelle P Howell, Steven Mitchell, Andrew Latimer, Kevin Doerschug, Vikas Koppurapu, Alicia K Cupelo, Paige DeVries, Sally Dye, Andrea Fletcher, Christopher S Gray, Kevin High, Michael C Kurz, Carol L Lyle, Justin Oeth, Erika LW Rice, Alexandra Schick, Jamie Stang, Nathaniel D Westphal, Tak Watase, Raquel R Bartz, William C Fox, Bret D Alvis, Stephanie C Demasi, Laura E Goyack, Kristy K Ford, Trevor S Mattox, Sheylan D Patel, G Bruno Pereira, Anthony Defebio, Jennifer Friedel, Feysel Mohamed, Karina Nava, Angela Otoo, Christian Perez, and Cori Withers
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Medicine - Abstract
Introduction Intubation-related complications are less frequent when intubation is successful on the first attempt. The rate of first attempt success in the emergency department (ED) and intensive care unit (ICU) is typically less than 90%. The bougie, a semirigid introducer that can be placed into the trachea to facilitate a Seldinger-like technique of tracheal intubation and is typically reserved for difficult or failed intubations, might improve first attempt success. Evidence supporting its use, however, is from a single academic ED with frequent bougie use. Validation of these findings is needed before widespread implementation.Methods and analysis The BOugie or stylet in patients Undergoing Intubation Emergently trial is a prospective, multicentre, non-blinded randomised trial being conducted in six EDs and six ICUs in the USA. The trial plans to enrol 1106 critically ill adults undergoing orotracheal intubation. Eligible patients are randomised 1:1 for the use of a bougie or use of an endotracheal tube with stylet for the first intubation attempt. The primary outcome is successful intubation on the first attempt. The secondary outcome is severe hypoxaemia, defined as an oxygen saturation less than 80% between induction until 2 min after completion of intubation. Enrolment began on 29 April 2019 and is expected to be completed in 2021.Ethics and dissemination The trial protocol was approved with waiver of informed consent by the Central Institutional Review Board at Vanderbilt University Medical Center or the local institutional review board at an enrolling site. The results will be submitted for publication in a peer-reviewed journal and presented at scientific conferences.Trial registration number ClinicalTrials.gov Registry (NCT03928925).
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- 2021
- Full Text
- View/download PDF
6. Video performance of 'Parade'
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Alysia Nicole Harris
- Subjects
Language and Literature ,Literature (General) ,PN1-6790 - Abstract
Video performance of “Parade” by Alysia Harris
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- 2019
- Full Text
- View/download PDF
7. Review: Improving access to mental health interventions for children from birth to five years: A Scoping Review
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Lyndal Hickey, Louise Harms, Jackson Evans, Tahnee Noakes, Henrietta Lee, Amity McSwan, Helena Bean, Judith Hope, Lynne Allison, Sophie Price, and Nicole Harris
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Psychiatry and Mental health ,Pediatrics, Perinatology and Child Health - Published
- 2023
8. Emotion Recognition and EEG Analysis Using ADMM-Based Sparse Group Lasso
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Jodi Tommerdahl, Jung-Chih Chiao, Jay M. Rosenberger, Yuan Bo Peng, Shouyi Wang, Peter Lehmann, Kin Ming Puk, Kellen Gandy, Anne Nordberg, and Haley Nicole Harris
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Quantitative Biology::Neurons and Cognition ,Channel (digital image) ,medicine.diagnostic_test ,Computer science ,business.industry ,Brain activity and meditation ,010401 analytical chemistry ,020206 networking & telecommunications ,Feature selection ,Pattern recognition ,02 engineering and technology ,Electroencephalography ,01 natural sciences ,0104 chemical sciences ,Human-Computer Interaction ,Pattern recognition (psychology) ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Feature (machine learning) ,Artificial intelligence ,business ,Affective computing ,Software ,Interpretability - Abstract
This study presents an efficient sparse learning-based pattern recognition framework to recognize the discrete states of three emotions-happy, angry, and neutral emotion-using electroencephalogram (EEG) signals. In affective computing with massive spatiotemporal brainwave signals, a large number of features can be extracted to capture various information from multivariate brain data. However, it is often a challenge to model high-dimensional features efficiently in consideration of the intrinsic structure, such as channel location, feature group, time epoch, etc. In this study, features were extensively extracted from EEG signals and were applied on a structured sparse learning model to perform feature selection and classification simultaneously. An efficient ADMM-based algorithm with a closed-form solution was developed to solve the sparse group model. Experimental results show that the proposed method is capable of selecting a small number of important neural features to discriminate the three emotion states with high classification accuracy. With greatly enhanced interpretability and efficiency to learn neural signatures of brain activity from high-dimensional-feature, low-sample-size brain imaging data, the presented computational framework is promising for handling emotion recognition problems with high-dimensional brain imaging data.
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- 2022
9. Preventing hip fractures with multidisciplinary teams: a Canadian perspective
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Nicole Harris, Johanna Dobransky, George Grammatopoulos, Steven Papp, Ethan Sanders, Lara Cheaitani, and Allan Liew
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Patient Care Team ,Hip fracture ,medicine.medical_specialty ,Bone Density Conservation Agents ,Hip Fractures ,business.industry ,Perspective (graphical) ,Specialty ,MEDLINE ,Review ,medicine.disease ,Patient counselling ,Medical care ,Primary Prevention ,Fractures, Spontaneous ,Multidisciplinary approach ,Health care ,Secondary Prevention ,medicine ,Humans ,Surgery ,business ,Intensive care medicine ,health care economics and organizations - Abstract
Fragility fractures (FFs) are low-energy trauma fractures that occur at or below standing height. Among FFs, hip fractures are associated with the greatest morbidity, mortality and cost to Canadian health care systems. This review highlights the current state of medical care for hip fractures in Canada, with specific focus on the role of the multidisciplinary team. Gaps in care exist, as FFs represent a unique challenge requiring both acute and chronic management. Furthermore, there is a lack of ownership of FFs by a medical specialty. These gaps can be addressed through the use of multidisciplinary teams, which have been shown to be efficacious and cost-effective. This model of care also addresses numerous patient-identified barriers to treatment, including inadequate patient counselling. However, there is still room for improvement in both the identification of patients at risk for hip fracture and patient adherence to therapy.Les fractures de fragilisation (FF) sont des fractures qui surviennent lors d’un traumatisme léger se produisant depuis la position debout ou d’une hauteur moindre. Les fractures de la hanche sont les FF associées aux plus grands taux de morbidité et de mortalité et aux plus grands coûts pour les systèmes de santé au Canada. La présente revue s’intéresse à l’état actuel des soins médicaux pour une fracture de la hanche au pays et porte une attention spéciale au rôle de l’équipe multidisciplinaire. Des lacunes dans les soins existent et sont mises en évidence par les FF, qui posent un défi bien particulier en nécessitant une prise en charge à la fois aiguë et chronique. De plus, cette prise en charge ne relève d’aucune spécialité médicale. La correction de ces lacunes peut passer par le recours aux équipes multidisciplinaires, dont l’efficacité et la rentabilité ont été démontrées. Ce modèle de soins élimine également de nombreux obstacles au traitement signalés par les patients, y compris le counseling inadéquat. Des améliorations sont néanmoins encore nécessaires dans l’identification des patients à risque de fracture de la hanche et dans l’observance du traitement.
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- 2021
10. Pain, Analgesic Use, and Patient Satisfaction With Spinal Versus General Anesthesia for Hip Fracture Surgery : A Randomized Clinical Trial
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Mark D, Neuman, Rui, Feng, Susan S, Ellenberg, Frederick, Sieber, Daniel I, Sessler, Jay, Magaziner, Nabil, Elkassabany, Eric S, Schwenk, Derek, Dillane, Edward R, Marcantonio, Diane, Menio, Sabry, Ayad, Manal, Hassan, Trevor, Stone, Steven, Papp, Derek, Donegan, Mitchell, Marshall, J Douglas, Jaffe, Charles, Luke, Balram, Sharma, Syed, Azim, Robert, Hymes, Ki-Jinn, Chin, Richard, Sheppard, Barry, Perlman, Joshua, Sappenfield, Ellen, Hauck, Mark A, Hoeft, Ann, Tierney, Lakisha J, Gaskins, Annamarie D, Horan, Trina, Brown, James, Dattilo, Jeffrey L, Carson, Thomas, Looke, Sandra, Bent, Ariana, Franco-Mora, Pamela, Hedrick, Matthew, Newbern, Rafik, Tadros, Karen, Pealer, Kamen, Vlassakov, Carolyn, Buckley, Lauren, Gavin, Svetlana, Gorbatov, James, Gosnell, Talora, Steen, Avery, Vafai, Jose, Zeballos, Jennifer, Hruslinski, Louis, Cardenas, Ashley, Berry, John, Getchell, Nicholas, Quercetti, Gauasan, Bajracharya, Damien, Billow, Michael, Bloomfield, Evis, Cuko, Mehrun K, Elyaderani, Robert, Hampton, Hooman, Honar, Dilara, Khoshknabi, Daniel, Kim, David, Krahe, Michael M, Lew, Conjeevram B, Maheshwer, Azfar, Niazi, Partha, Saha, Ahmed, Salih, Robert J, de Swart, Andrew, Volio, Kelly, Bolkus, Matthew, DeAngelis, Gregory, Dodson, Jeffrey, Gerritsen, Brian, McEniry, Ludmil, Mitrev, M Kwesi, Kwofie, Anne, Belliveau, Flynn, Bonazza, Vera, Lloyd, Izabela, Panek, Jared, Dabiri, Chris, Chavez, Jason, Craig, Todd, Davidson, Chad, Dietrichs, Cheryl, Fleetwood, Mike, Foley, Chris, Getto, Susie, Hailes, Sarah, Hermes, Andy, Hooper, Greg, Koener, Kate, Kohls, Leslie, Law, Adam, Lipp, Allison, Losey, William, Nelson, Mario, Nieto, Pam, Rogers, Steve, Rutman, Garrett, Scales, Barbara, Sebastian, Tom, Stanciu, Gregg, Lobel, Michelle, Giampiccolo, Dara, Herman, Margit, Kaufman, Bryan, Murphy, Clara, Pau, Thomas, Puzio, Marlene, Veselsky, Kelly, Apostle, Dory, Boyer, Brenda Chen, Fan, Susan, Lee, Mike, Lemke, Richard, Merchant, Farhad, Moola, Kyrsten, Payne, Bertrand, Perey, Darius, Viskontas, Mark, Poler, Patricia, D'Antonio, Greg, O'Neill, Amer, Abdullah, Jamie, Fish-Fuhrmann, Mark, Giska, Christina, Fidkowski, Stuart Trent, Guthrie, William, Hakeos, Lillian, Hayes, Joseph, Hoegler, Katherine, Nowak, Jeffery, Beck, Jaslynn, Cuff, Greg, Gaski, Sharon, Haaser, Michael, Holzman, A Stephen, Malekzadeh, Lolita, Ramsey, Jeff, Schulman, Cary, Schwartzbach, Tangwan, Azefor, Arman, Davani, Mahmood, Jaberi, Courtney, Masear, Syed Basit, Haider, Carolyn, Chungu, Ali, Ebrahimi, Karim, Fikry, Andrew, Marcantonio, Anitha, Shelvan, David, Sanders, Collin, Clarke, Abdel, Lawendy, Gary, Schwartz, Mohit, Garg, Joseph, Kim, Juan, Caruci, Ekow, Commeh, Randy, Cuevas, Germaine, Cuff, Lola, Franco, David, Furgiuele, Matthew, Giuca, Melissa, Allman, Omid, Barzideh, James, Cossaro, Armando, D'Arduini, Anita, Farhi, Jason, Gould, John, Kafel, Anuj, Patel, Abraham, Peller, Hadas, Reshef, Mohammed, Safur, Fiore, Toscano, Tiffany, Tedore, Michael, Akerman, Eric, Brumberger, Sunday, Clark, Rachel, Friedlander, Anita, Jegarl, Joseph, Lane, John P, Lyden, Nili, Mehta, Matthew T, Murrell, Nathan, Painter, William, Ricci, Kaitlyn, Sbrollini, Rahul, Sharma, Peter A D, Steel, Michele, Steinkamp, Roniel, Weinberg, David Stephenson, Wellman, Antoun, Nader, Paul, Fitzgerald, Michaela, Ritz, Greg, Bryson, Alexandra, Craig, Cassandra, Farhat, Braden, Gammon, Wade, Gofton, Nicole, Harris, Karl, Lalonde, Allan, Liew, Bradley, Meulenkamp, Kendra, Sonnenburg, Eugene, Wai, Geoffrey, Wilkin, Karen, Troxell, Mary Ellen, Alderfer, Jason, Brannen, Christopher, Cupitt, Stacy, Gerhart, Renee, McLin, Julie, Sheidy, Katherine, Yurick, Fei, Chen, Karen, Dragert, Geza, Kiss, Halina, Malveaux, Deborah, McCloskey, Scott, Mellender, Sagar S, Mungekar, Helaine, Noveck, Carlos, Sagebien, Luat, Biby, Gail, McKelvy, Anna, Richards, Ramon, Abola, Brittney, Ayala, Darcy, Halper, Ana, Mavarez, Sabeen, Rizwan, Stephen, Choi, Imad, Awad, Brendan, Flynn, Patrick, Henry, Richard, Jenkinson, Lilia, Kaustov, Elizabeth, Lappin, Paul, McHardy, Amara, Singh, Joanne, Donnelly, Meera, Gonzalez, Christopher, Haydel, Jon, Livelsberger, Theresa, Pazionis, Bridget, Slattery, Maritza, Vazquez-Trejo, Jaime, Baratta, Michael, Cirullo, Brittany, Deiling, Laura, Deschamps, Michael, Glick, Daniel, Katz, James, Krieg, Jennifer, Lessin, Jeffrey, Mojica, Marc, Torjman, Rongyu, Jin, Mary Jane, Salpeter, Mark, Powell, Jeffrey, Simmons, Prentiss, Lawson, Promil, Kukreja, Shanna, Graves, Adam, Sturdivant, Ayesha, Bryant, Sandra Joyce, Crump, Michelle, Verrier, James, Green, Matthew, Menon, Richard, Applegate, Ana, Arias, Natasha, Pineiro, Jeffrey, Uppington, Phillip, Wolinsky, Amy, Gunnett, Jennifer, Hagen, Sara, Harris, Kevin, Hollen, Brian, Holloway, Mary Beth, Horodyski, Trevor, Pogue, Ramachandran, Ramani, Cameron, Smith, Anna, Woods, Matthew, Warrick, Kelly, Flynn, Paul, Mongan, Yatish, Ranganath, Sean, Fernholz, Esperanza, Ingersoll-Weng, Anil, Marian, Melinda, Seering, Zita, Sibenaller, Lori, Stout, Allison, Wagner, Alicia, Walter, Cynthia, Wong, Denise, Orwig, Maithri, Goud, Chris, Helker, Lydia, Mezenghie, Brittany, Montgomery, Peter, Preston, J Sanford, Schwartz, Ramona, Weber, Lee A, Fleisher, Samir, Mehta, Alisa J, Stephens-Shields, Cassandra, Dinh, Jacques E, Chelly, Shiv, Goel, Wende, Goncz, Touichi, Kawabe, Sharad, Khetarpal, Amy, Monroe, Vladislav, Shick, Max, Breidenstein, Timothy, Dominick, Alexander, Friend, Donald, Mathews, Richard, Lennertz, Robert, Sanders, Helen, Akere, Tyler, Balweg, Amber, Bo, Christopher, Doro, David, Goodspeed, Gerald, Lang, Maggie, Parker, Amy, Rettammel, Mary, Roth, Marissa, White, Paul, Whiting, Brian F S, Allen, Tracie, Baker, Debra, Craven, Matt, McEvoy, Teresa, Turnbo, Stephen, Kates, Melanie, Morgan, Teresa, Willoughby, Wade, Weigel, David, Auyong, Ellie, Fox, Tina, Welsh, Bruce, Cusson, Sean, Dobson, Christopher, Edwards, Lynette, Harris, Daryl, Henshaw, Kathleen, Johnson, Glen, McKinney, Scott, Miller, Jon, Reynolds, B Scott, Segal, Jimmy, Turner, David, VanEenenaam, Robert, Weller, Jineli, Lei, Miriam, Treggiari, Shamsuddin, Akhtar, Marcelle, Blessing, Chanel, Johnson, Michael, Kampp, Kimberly, Kunze, Mary, O'Connor, Jinlei, Li, Duminda N, Wijeysundera, Sachin, Kheterpal, Reneé H, Moore, Alexander K, Smith, Laura L, Tosi, Lee, Fleisher, Christine, Langlois, Samuel, Oduwole, and Thomas, Rose
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Male ,Analgesics ,Canada ,Pain, Postoperative ,Hip Fractures ,Pain ,General Medicine ,Anesthesia, General ,Anesthesia, Spinal ,Patient Satisfaction ,Internal Medicine ,Humans ,Female ,Aged - Abstract
The REGAIN (Regional versus General Anesthesia for Promoting Independence after Hip Fracture) trial found similar ambulation and survival at 60 days with spinal versus general anesthesia for hip fracture surgery. Trial outcomes evaluating pain, prescription analgesic use, and patient satisfaction have not yet been reported.To compare pain, analgesic use, and satisfaction after hip fracture surgery with spinal versus general anesthesia.Preplanned secondary analysis of a pragmatic randomized trial. (ClinicalTrials.gov: NCT02507505).46 U.S. and Canadian hospitals.Patients aged 50 years or older undergoing hip fracture surgery.Spinal or general anesthesia.Pain on postoperative days 1 through 3; 60-, 180-, and 365-day pain and prescription analgesic use; and satisfaction with care.A total of 1600 patients were enrolled. The average age was 78 years, and 77% were women. A total of 73.5% (1050 of 1428) of patients reported severe pain during the first 24 hours after surgery. Worst pain over the first 24 hours after surgery was greater with spinal anesthesia (rated from 0 [no pain] to 10 [worst pain imaginable]; mean difference, 0.40 [95% CI, 0.12 to 0.68]). Pain did not differ across groups at other time points. Prescription analgesic use at 60 days occurred in 25% (141 of 563) and 18.8% (108 of 574) of patients assigned to spinal and general anesthesia, respectively (relative risk, 1.33 [CI, 1.06 to 1.65]). Satisfaction was similar across groups.Missing outcome data and multiple outcomes assessed.Severe pain is common after hip fracture. Spinal anesthesia was associated with more pain in the first 24 hours after surgery and more prescription analgesic use at 60 days compared with general anesthesia.Patient-Centered Outcomes Research Institute
- Published
- 2022
11. Electronic Cigarettes: Exposure to Secondhand Vapors at a Long-Term Healthcare Company
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Kermit G. Davis, Gordon Lee Gillespie, and Nicole Harris
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Smoke ,business.industry ,Article ,law.invention ,Quantitative sampling ,Long-term care ,Exposure level ,law ,Environmental health ,Passive inhalation ,Health care ,Medicine ,business ,Secondhand smoke ,Electronic cigarette - Abstract
Introduction: Healthcare workers in long term care settings have limited control over their occupational secondhand exposure to electronic cigarettes and other tobacco products.Methods: The study aimed to identify the perceived frequency of exposure to exhaled electronic cigarette vapor on healthcare workers within two sites of a long-term healthcare company. An online survey was completed by 149 (out of approximately 500) employees that asked about electronic cigarette personal usage, concerns for exposure, exposure times, and demographic data.Results: Twelve percent of all survey respondents expressed concerns related to second-hand exposure. Of those exposed, employee estimated exposure time was 2.1 minutes per shift for electronic cigarettes compared to 12.1 minutes per shift for cigarettes/cigars/pipes.Conclusions: Overall self-reported secondhand exposure to electronic cigarettes and cigarettes/cigars/pipes was low. To determine a definitive exposure level, quantitative sampling can be done related to chemical exposure via passive inhalation of the smoke and vapor cloud for cigarettes and electronic cigarettes, respectively. Education can be provided to healthcare workers and residents in long-term care facilities regarding risk of exposure to secondhand smoke to alleviate employees' concerns with exposure.
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- 2022
12. Parents in Prison
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Chesa Boudin and Nicole Harris
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media_common.quotation_subject ,Prison ,Sociology ,Criminology ,media_common - Published
- 2020
13. A multidisciplinary approach and consensus statement to establish standards of care for Angelman syndrome
- Author
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Jessica Duis, Mark Nespeca, Jane Summers, Lynne Bird, Karen G.C.B. Bindels‐de Heus, M. J. Valstar, Marie‐Claire Y. Wit, C. Navis, Maartje ten Hooven‐Radstaake, Bianca M. Iperen‐Kolk, Susan Ernst, Melina Dendrinos, Terry Katz, Gloria Diaz‐Medina, Akshat Katyayan, Srishti Nangia, Ronald Thibert, Daniel Glaze, Christopher Keary, Karine Pelc, Nicole Simon, Anjali Sadhwani, Helen Heussler, Anne Wheeler, Caroline Woeber, Margaret DeRamus, Amy Thomas, Emily Kertcher, Lauren DeValk, Kristen Kalemeris, Kara Arps, Carol Baym, Nicole Harris, John P. Gorham, Brenda L. Bohnsack, Reid C. Chambers, Sarah Harris, Henry G. Chambers, Katherine Okoniewski, Elizabeth R. Jalazo, Allyson Berent, Carlos A. Bacino, Charles Williams, and Anne Anderson
- Subjects
Genetics ,Humans ,Standard of Care ,Angelman Syndrome ,Molecular Biology ,Genetics (clinical) - Abstract
Background: Angelman syndrome (AS) is a rare neurogenetic disorder present in approximately 1/12,000 individuals and characterized by developmental delay, cognitive impairment, motor dysfunction, seizures, gastrointestinal concerns, and abnormal electroencephalographic background. AS is caused by absent expression of the paternally imprinted gene UBE3A in the central nervous system. Disparities in the management of AS are a major problem in preparing for precision therapies and occur even in patients with access to experts and recognized clinics. AS patients receive care based on collective provider experience due to limited evidence-based literature. We present a consensus statement and comprehensive literature review that proposes a standard of care practices for the management of AS at a critical time when therapeutics to alter the natural history of the disease are on the horizon. Methods: We compiled the key recognized clinical features of AS based on consensus from a team of specialists managing patients with AS. Working groups were established to address each focus area with committees comprised of providers who manage >5 individuals. Committees developed management guidelines for their area of expertise. These were compiled into a final document to provide a framework for standardizing management. Evidence from the medical literature was also comprehensively reviewed. Results: Areas covered by working groups in the consensus document include genetics, developmental medicine, psychology, general health concerns, neurology (including movement disorders), sleep, psychiatry, orthopedics, ophthalmology, communication, early intervention and therapies, and caregiver health. Working groups created frameworks, including flowcharts and tables, to help with quick access for providers. Data from the literature were incorporated to ensure providers had review of experiential versus evidence-based care guidelines. Conclusion: Standards of care in the management of AS are keys to ensure optimal care at a critical time when new disease-modifying therapies are emerging. This document is a framework for providers of all familiarity levels.
- Published
- 2021
14. Urinary catheter use in patients with hip fracture: Are current guidelines appropriate? A retrospective review
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Kathleen Gartke, George Grammatopoulos, Johanna Dobransky, Sruthi Thomas, Allan Liew, Steven Papp, and Nicole Harris
- Subjects
Male ,medicine.medical_specialty ,Bacteriuria ,medicine.medical_treatment ,Urinary system ,Urinary Catheters ,Urinary catheterization ,Catheters, Indwelling ,Postoperative Complications ,Risk Factors ,medicine ,Humans ,Postoperative Period ,Aged ,Retrospective Studies ,Aged, 80 and over ,Ontario ,Postoperative Care ,Hip fracture ,Urinary retention ,business.industry ,Hip Fractures ,Incidence (epidemiology) ,Research ,Odds ratio ,Middle Aged ,Urinary Retention ,medicine.disease ,Confidence interval ,Surgery ,Catheter ,Urinary Tract Infections ,Female ,medicine.symptom ,business ,Urinary Catheterization - Abstract
Background: Guidelines for urinary catheterization in patients with hip fracture recommend limiting catheter use and using intermittent catheterization preferentially to avoid complications such as urinary tract infection (UTI) and postoperative urinary retention (POUR). We aimed to compare current practices to clinical guidelines, describe the incidence of POUR and UTI, and determine factors that increase the risk of these complications. Methods: We retrospectively reviewed the charts of patients with hip fracture who presented to a single large tertiary care centre in southeastern Ontario between November 2015 and October 2017. Data collected included comorbidities, catheter use and length of stay. We compared catheter use to guidelines, and investigated the incidence of and risk factors for POUR and UTI. Results: We reviewed the charts of 583 patients, of whom 450 (77.2%) were treated with a catheter, primarily indwelling (416 [92.4%]). Postoperative urinary retention developed in 98 patients (16.8%); however, it did not affect length of stay (p = 0.2). Patients with indwelling catheters for more than 24 hours after surgery had a higher incidence of POUR than those who had their catheter removed before 24 hours (65/330 [19.7%] v. 10/98 [10.2%]) (odds ratio [OR] 2.2, 95% confidence interval [CI] 1.06–4.38). A UTI developed postoperatively in 62 patients (10.6%). Catheter use was associated with a 6.6-fold increased risk of UTI (OR 6.6, 95% CI 2.03–21.4). Patients with indwelling catheters did not have a significantly higher incidence of UTI than those with intermittent catheterization (57/416 [13.7%] v. 2/34 [5.9%]) (p = 0.2). Patients who developed a UTI had significantly longer catheter use than patients who did not (p < 0.002). Conclusion: Indwelling catheters were used frequently, which suggests low compliance with clinical guidelines. Longer duration of catheter use led to higher rates of UTI and POUR. Further investigation of the reasons for the common use of indwelling rather than intermittent catheterization is needed.
- Published
- 2021
15. 'Capital'izing on Cultural Wealth and Sense of Belonging: Narratives of Successful Students of Color in a Teacher Preparation Program
- Author
-
Nicole Harris
- Published
- 2021
16. Engaging patients as partners in a multicentre trial of spinal versus general anaesthesia for older adults
- Author
-
Jennifer Hruslinski, Diane A. Menio, Robert A. Hymes, J. Douglas Jaffe, Christine Langlois, Lolita Ramsey, Lakisha J. Gaskins, Mark D. Neuman, Thomas Looke, Sandra Bent, Ariana Franco-Mora, Pamela Hedrick, Matthew Newbern, Rafik Tadros, Karen Pealer, Edward Marcantonio, Kamen Vlassakov, Carolyn Buckley, Svetlana Gorbatov, James Gosnell, Talora Steen, Avery Vafai, Jose Zeballos, Louis Cardenas, Ashley Berry, John Getchell, Nicholas Quercetti, Daniel I. Sessler, Sabry Ayad, Manal Hassan, Assad Ali, Gauasan Bajracharya, Damien Billow, Michael Bloomfield, Kavita Elliott, Robert Hampton, Linda He, Hooman Honar, Dilara Khoshknabi, Daniel Kim, Paul Minko, Adam Morris, Azfar Niazi, Tara Nutcharoen, Jeffrey Roberts, Partha Saha, Ahmed Salih, Alexis Skolaris, Taylor Stang, Victor Strimbu, Jesse Templeton, Andrew Volio, Jiayi Wang, Kelly Bolkus, Matthew DeAngelis, Gregory Dodson, Jeffrey Gerritsen, Brian McEniry, Ludmil Mitrev, Kwesi Kwofie, Flynn Bonazza, Vera Lloyd, Izabela Panek, Jared Dabiri, Chris Chavez, Jason Craig, Todd Davidson, Chad Dietrichs, Cheryl Fleetwood, Mike Foley, Chris Getto, Susie Hailes, Sarah Hermes, Andy Hooper, Greg Koener, Kate Kohls, Leslie Law, Adam Lipp, Allison Losey, William Nelson, Mario Nieto, Pam Rogers, Steve Rutman, Garrett Scales, Barbara Sebastian, Tom Stanciu, Gregg Lobel, Michelle Giampiccolo, Dara Herman, Margit Kaufman, Bryan Murphy, Clara Pau, Thomas Puzio, Marlene Veselsky, Trevor Stone, Kelly Apostle, Dory Boyer, Brenda Chen Fan, Susan Lee, Mike Lemke, Richard Merchant, Farhad Moola, Kyrsten Payne, Bertrand Perey, Darius Viskontas, Mark Poler, Patricia D'Antonio, Richard Sheppard, Amer Abdullah, Jamie Fish-Fuhrmann, Mark Giska, Christina Fidkowski, Trent Guthrie, William Hakeos, Lillian Hayes, Joseph Hoegler, Katherine Nowak, Robert Hymes, Jeffery Beck, Jaslynn Cuff, Greg Gaski, Sharon Haaser, Michael Holzman, A. Stephen Malekzadeh, Jeff Schulman, Cary Schwartzbach, Frederick Sieber, Tangwan Azefor, Charles Brown, Arman Davani, Mahmood Jaberi, Courtney Masear, Balram Sharma, Syed Basit Haider, Carolyn Chungu, Ali Ebrahimi, Karim Fikry, Kerri Gannon, Andrew Marcantonio, Meredith Pace, David Sanders, Collin Clarke, Abdel Lawendy, Gary Schwartz, Mohit Garg, Joseph Kim, Mitchell Marshall, Juan Caurci, Ekow Commeh, Randy Cuevas, Germaine Cuff, Lola Franco, David Furguiele, Matthew Giuca, Melissa Allman, Omid Barzideh, James Cossaro, Armando D'Arduini, Anita Farhi, Jason Gould, John Kafel, Anuj Patel, Abraham Peller, Hadas Reshef, Mohammed Safur, Fiore Toscano, Tiffany Tedore, Michael Akerman, Eric Brumberger, Sunday Clark, Rachel Friedlander, Anita Jegarl, Joseph Lane, John P. Lyden, Nili Mehta, Matthew T. Murrell, Nathan Painter, William Ricci, Kaitlyn Sbrollini, Rahul Sharma, Peter A.D. Steel, Michele Steinkamp, Roniel Weinberg, David Stephenson Wellman, Antoun Nader, Paul Fitzgerald, Michaela Ritz, Steven Papp, Greg Bryson, Alexandra Craig, Cassandra Farhat, Braden Gammon, Wade Gofton, Nicole Harris, Karl Lalonde, Allan Liew, Bradley Meulenkamp, Kendra Sonnenburg, Eugene Wai, Geoffrey Wilkin, Derek Donegan, Cassandra Dinh, Nabil Elkassabany, Annamarie Horan, Samir Mehta, Karen Troxell, Mary Ellen Alderfer, Jason Brannen, Christopher Cupitt, Stacy Gerhart, Renee McLin, Julie Sheidy, Katherine Yurick, Jeffrey Carson, Fei Chen, Karen Dragert, Geza Kiss, Halina Malveaux, Deborah McCloskey, Scott Mellender, Sagar S. Mungekar, Helaine Noveck, Carlos Sagebien, Barry Perlman, Luat Biby, Gail McKelvy, Anna Richards, Syed Azim, Ramon Abola, Brittney Ayala, Darcy Halper, Ana Mavarez, Stephen Choi, Imad Awad, Brendan Flynn, Patrick Henry, Richard Jenkinson, Lilia Kaustov, Elizabeth Lappin, Paul McHardy, Amara Singh, Ellen Hauck, Joanne Donnelly, Meera Gonzalez, Christopher Haydel, Jon Livelsberger, Theresa Pazionis, Bridget Slattery, Maritza Vazquez-Trejo, Eric Schwenk, Jaime Baratta, Brittany Deiling, Laura Deschamps, Michael Glick, Daniel Katz, James Krieg, Jennifer Lessin, Marc Torjman, Ki Jinn Chin, Rongyu Jin, Mary Jane Salpeter, Mark Powell, Jeffrey Simmons, Prentiss Lawson, Promil Kukreja, Shanna Graves, Adam Sturdivant, Ayesha Bryant, Sandra Joyce Crump, Derek Dillane, Michael Taylor, Michelle Verrier, Richard Applegate, Ana Arias, Natasha Pineiro, Jeffrey Uppington, Phillip Wolinsky, Joshua Sappenfield, Amy Gunnett, Jennifer Hagen, Sara Harris, Kevin Hollen, Brian Holloway, Mary Beth Horodyski, Trevor Pogue, Ramachandran Ramani, Cameron Smith, Anna Woods, Matthew Warrick, Kelly Flynn, Paul Mongan, Yatish Ranganath, Sean Fernholz, Esperanza Ingersoll-Weng, Anil Marian, Melinda Seering, Zita Sibenaller, Lori Stout, Allison Wagner, Alicia Walter, Cynthia Wong, Jay Magaziner, Denise Orwig, Trina Brown, Jim Dattilo, Susan Ellenberg, Rui Feng, Lee Fleisher, Lakisha Gaskins, Maithri Goud, Chris Helker, Lydia Mezenghie, Brittany Montgomery, Peter Preston, Alisa Stephens, J. Sanford Schwartz, Ann Tierney, Ramona Weber, Jacques Chelly, Shiv Goel, Wende Goncz, Touichi Kawabe, Sharad Khetarpal, Kevin King, Frank Kunkel, Charles Luke, Amy Monroe, Vladislav Shick, Anthony Silipo, Caroline Stehle, Katherine Szabo, Sudhakar Yennam, Mark Hoeft, Max Breidenstein, Timothy Dominick, Alexander Friend, Donald Mathews, Richard Lennertz, Helen Akere, Tyler Balweg, Amber Bo, Christopher Doro, David Goodspeed, Gerald Lang, Maggie Parker, Amy Rettammel, Mary Roth, Robert Sanders, Marissa White, Paul Whiting, Brian Allen, Tracie Baker, Debra Craven, Matt McEvoy, Teresa Turnbo, Stephen Kates, Melanie Morgan, Teresa Willoughby, Wade Weigel, David Auyong, Ellie Fox, Tina Welsh, Bruce Cusson, Sean Dobson, Christopher Edwards, Lynette Harris, Daryl Henshaw, Kathleen Johnson, Glen McKinney, Scott Miller, Jon Reynolds, Jimmy Turner, David VanEenenaam, Robert Weller, Shamsuddin Akhtar, Marcelle Blessing, Chanel Johnson, Michael Kampp, Kimberly Kunze, Jinlei Li, Mary O'Connor, and Miriam Treggiari
- Subjects
medicine.medical_specialty ,Canada ,Research Subjects ,Patient engagement ,Hip fracture surgery ,Patient Advocacy ,Anesthesia, General ,Patient advocacy ,Anesthesia, Spinal ,03 medical and health sciences ,0302 clinical medicine ,Nursing ,030202 anesthesiology ,Fracture Fixation ,Medicine ,Humans ,General anaesthesia ,Cooperative Behavior ,Geriatrics ,Hip fracture ,business.industry ,Hip Fractures ,Lived experience ,Age Factors ,Research process ,medicine.disease ,United States ,Anesthesiology and Pain Medicine ,Research Design ,Patient Participation ,business ,Decision Making, Shared - Abstract
Summary Engaging patients—defined broadly as individuals with lived experience of a given condition, family members, caregivers, and the organisations that represent them—as partners in research is a priority for policymakers, funders, and the public. Nonetheless, formal efforts to engage patients are absent from most studies, and models to support meaningful patient engagement in clinical anaesthesia research have not been previously described. Here, we review our experience in developing and implementing a multifaceted patient engagement strategy within the Regional Versus General Anesthesia for Promoting Independence After Hip Fracture (REGAIN) surgery trial, an ongoing randomised trial comparing spinal vs general anaesthesia for hip fracture surgery in 1600 older adults across 45 hospitals in the USA and Canada. This strategy engaged patients and their representatives at both the level of overall trial oversight and at the level of individual recruiting sites. Activities spanned a continuum ranging from events designed to elicit patients' input on key decisions to longitudinal collaborations that empowered patients to actively participate in decision-making related to trial design and management. Engagement activities were highly acceptable to participants and led to concrete changes in the design and conduct of the REGAIN trial. The REGAIN experience offers a model for future efforts to engage patients as partners in clinical anaesthesia research, and highlights potential opportunities for investigators to increase the relevance of anaesthesia studies by incorporating patient voices and perspectives into the research process.
- Published
- 2020
17. Deliverable 2.1 Collaborative platform technical description
- Author
-
Vladimir Cvijanović, Alasdair Reid, Nicole Harris, and Brook Schofield
- Subjects
Privacy and Trust Enhancing Technologies ,Human Centric Internet - Abstract
This report provides a short description of the collaborative platform used by the NGI_TRUST project which has been developed as a Wiki with both public facing and password protected pages, the latter used by the project team to manage third party projects and exchange information.
- Published
- 2020
- Full Text
- View/download PDF
18. Commentary on 'The Effects of Functional Progressive Strength and Power Training in Children With Unilateral Cerebral Palsy'
- Author
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Nicole Harris and Kara Copanas
- Subjects
medicine.medical_specialty ,business.industry ,Cerebral Palsy ,MEDLINE ,Resistance training ,Physical Therapy, Sports Therapy and Rehabilitation ,Resistance Training ,medicine.disease ,Cerebral palsy ,Physical medicine and rehabilitation ,Text mining ,Pediatrics, Perinatology and Child Health ,medicine ,Muscle strength ,Humans ,Muscle Strength ,business ,Child - Published
- 2019
19. WISE Information Security for Collaborating e-Infrastructures
- Author
-
Romain Wartel, Hannah Short, Urpo Kaila, Nicole Harris, Ralph Niederberger, David Groep, and David Kelsey
- Subjects
business.industry ,Physics ,QC1-999 ,Information security ,Certification ,Computer security ,computer.software_genre ,Critical infrastructure ,Computing and Computers ,Work (electrical) ,Scale (social sciences) ,Relevance (information retrieval) ,business ,computer ,Operations security ,Risk management - Abstract
As most are fully aware, cybersecurity attacks are an ever-growing problem as larger parts of our lives take place on-line. Distributed digital infrastructures are no exception and action must be taken to both reduce the security risk and tohandle security incidents when they inevitably happen. These activities are carried out by the various research infrastructures and it has become very clear in recent years that collaboration with others both helps to improve the security and to work more efficiently. The Wise Information Security for Collaborating e-Infrastructures (WISE) community provides a trusted framework where security experts can share information on topics such as risk management, experiences about certification processes and threat intelligence. With participants from multiple large scale Infrastructures, WISE focuses on standards, guidelines and practices, and promotes the protection of critical infrastructure. To date WISE has published two documents; a risk management template and a second version of the SCI framework, endorsed by multiple large-scale infrastructures. In 2018 WISE began work on new areas of relevance to the High Energy Physics community, including a focus on operational security and incident response for interoperating infrastructures. We present an overview of the available WISE recommendations, future work and how WISE brings benefits to the High Energy Physics community.
- Published
- 2019
20. A Practical Analysis of the Rise in Mobile Phishing
- Author
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Blake Butler, Jakub Burgis, Nicole Harris, Michael Weideman, Brad Wardman, and Nate Pratt
- Subjects
business.industry ,Computer science ,Mobile Web ,02 engineering and technology ,Computer security ,computer.software_genre ,Phishing ,020204 information systems ,Return on investment ,0202 electrical engineering, electronic engineering, information engineering ,The Internet ,Mobile technology ,business ,computer - Abstract
Phishing attacks continue to evolve in order to bypass mitigations applied within the industry. These attacks are also changing due to the attacker’s desire for a greater return on investment from their attacks against the common internet user. The digital landscape has been ever-changing since the emergence of mobile technologies. The intersection of the internet and the growing mobile user-base fueled the natural progression of phishers to target mobile-specific users. This research investigates mobile-specific phishing attacks through the dissection of phishing kits used for the attacks, presentation of real world phishing campaigns, and observations about PayPal’s insight into mobile web-based phishing numbers.
- Published
- 2018
21. An ecological assessment of Foul and Folly Bays, Morant wetlands area, Jamaica using Ecopath with Ecosim
- Author
-
Gale Persad, Dale F. Webber, Mona K. Webber, Inilek Wilmot, and Nicole Harris
- Subjects
Biomass (ecology) ,Management, Monitoring, Policy and Law ,Aquatic Science ,Plankton ,Oceanography ,Zooplankton ,Fishery ,Phytoplankton ,EcoSim ,Environmental science ,Eutrophication ,Bay ,Trophic level - Abstract
The Morant wetlands bays (Foul and Folly Bays) are contiguous with the Great Morass, a large wetland located at the extreme eastern end of the island of Jamaica. A multidisciplinary ecological assessment of the bays was conducted from April 2007–May 2008 aimed at generating a baseline of conditions to confirm the trophic status and importance of the area thus providing support for its designation as a protected area. Water column assessment included zooplankton and phytoplankton collections for 12 months at 11 stations. Zooplankton tows were conducted using a 200 μm net (0.5 m hoop diameter) contemporaneous with 5 l Niskin bottle casts for phytoplankton. Zooplankton abundances were determined for nine functional groups (calanoids, cyclopoids, harpacticoids, nauplii, copepodites, carnivores: medusa and chaetognaths, larvaceans and larvae) for which equivalent biomass was generated using conversion factors based on previous studies in Jamaica. Total phytoplankton biomass (mg Chl a m −3 ) was determined directly using filtration (onto a 0.7 μm filter) and fluorometry while detritus was estimated using the model. Ecopath with Ecosim 5.1 was then used to model the trophic interactions of the planktonic community in the Morant wetlands bays. 116 different taxa of zooplankton were identified with a mean total abundance ranging from 282 ± 56 to 3459 ± 752 animals m −3 across the annual cycle. Total phytoplankton biomass (Chlorophyll a ) ranged from 0.14 ± 0.04 to 0.34 ± 0.2 mg m −3 across the annual cycle. A similar study in a pristine bay (Discovery Bay) on the north coast of Jamaica indicated mean zooplankton abundances between 1077 ± 191 and 3794 ± 87 animals m −3 and phytoplankton biomass between 0.4 and 0.8 mg m −3 . The plankton parameters suggest that Foul and Folly Bays are even more pristine than Discovery Bay and the Ecopath model indicated that unlike Discovery Bay, these Morant wetlands bays were far more resilient and therefore able to recover from stresses (e.g. eutrophication). However, there is still need for protection of this pristine area as the high abundance of larvae coupled with fast flowing currents through the bays provides evidence that this area could be an important source of larvae to other areas of Jamaica's south coast.
- Published
- 2015
22. Juvenile Chinook salmon, Oncorhynchus tshawytscha, use of the Elwha river estuary prior to dam removal
- Author
-
Justin M. Brown, Chris Byrnes, Patrick K. Crain, J. Anne Shaffer, Thomas P. Quinn, and Nicole Harris
- Subjects
Fish migration ,geography ,education.field_of_study ,Chinook wind ,geography.geographical_feature_category ,biology ,Dam removal ,Population ,Estuary ,Aquatic Science ,biology.organism_classification ,Fish measurement ,Hatchery ,Fishery ,Oncorhynchus ,Environmental science ,education ,Ecology, Evolution, Behavior and Systematics - Abstract
The estuary of the Elwha River, on Washington’s Olympic Peninsula, has been degraded and simplified over the past century from sediment retention behind two large dams, levee construction, and channelization. With the removal of Elwha Dam and initiation of Glines Canyon Dam’s removal in fall 2011, sediment deposits will change the estuary and affect anadromous and nearshore marine fishes. Juvenile Chinook salmon commonly use estuaries and the river’s population is part of an Evolutionarily Significant Unit listed as Threatened under the U.S. Endangered Species Act. This study reports on monthly sampling in part of the river’s estuary from March 2007 through September 2011 to characterize the seasonal changes in relative abundance of yearlings and sub-yearlings, and size distributions prior to dam removal. Most (69 %) of the yearlings were caught in April, when this life history type was released from the hatchery, and to a lesser extent in May (28 %) and June (3 %). Yearlings caught in the estuary were smaller than those released from the hatchery (means: 153 mm ± 28 SD vs. 175 mm ± 5 SD), suggesting more rapid departure by larger fish. Sub-yearlings were much more abundant in the estuary, and were caught from March through November, increasing in mean fork length by 8.7 mm month-1. The hatchery-origin sub-yearlings were not marked externally and so were not distinguishable from natural origin fish. However, 39 % of the sub-yearlings were caught prior to June, when sub-yearlings were released from the hatchery, indicating substantial use of the estuary by natural-origin fish. Thus, even in a reduced state after a century of dam operation, the highly modified estuary was used over many months by juvenile Chinook salmon. The information on juvenile Chinook salmon prior to dam removal provides a basis for comparison to patterns in the future, when the anticipated increase in estuarine complexity may further enhance habitat use by juvenile Chinook salmon.
- Published
- 2013
23. Juvenile Coho Salmon in the Elwha River Estuary Prior to Dam Removal: Seasonal Occupancy, Size Distribution, and Comparison to Nearby Salt Creek
- Author
-
J. Anne Shaffer, Patrick K. Crain, Chris Byrnes, Nicole Harris, and Thomas P. Quinn
- Subjects
0106 biological sciences ,geography ,geography.geographical_feature_category ,biology ,Occupancy ,010604 marine biology & hydrobiology ,Dam removal ,Estuary ,Aquatic Science ,biology.organism_classification ,010603 evolutionary biology ,01 natural sciences ,Fishery ,Lower Elwha ,Spring (hydrology) ,Fish hatchery ,Oncorhynchus ,Environmental science ,Juvenile ,14. Life underwater ,Ecology, Evolution, Behavior and Systematics - Abstract
In addition to the downstream migration of smolts in spring, Coho Salmon Oncorhynchus kisutch also enter estuaries throughout the year but especially in the spring as fry and in the fall as parr. The removal of two large dams on the Elwha River, Washington, has increased the area accessible to salmon and is affecting many aspects of the system. For comparison with the postdam period, when the Elwha River estuary will likely expand in size and complexity, monthly sampling was conducted in the estuary during 2007–2011 to determine patterns of Coho Salmon presence and size prior to dam removal; Salt Creek, a nearby undammed stream, was also sampled to allow comparison of fish size and seasonal timing patterns. The spring smolt migration in the Elwha River included a large fraction of unmarked fish (primarily of natural origin) as well as marked fish from the Lower Elwha Klallam Tribe Fish Hatchery. Subyearlings entered both estuaries during much of the year, exhibiting a peak in September. Coho Salm...
- Published
- 2013
24. Security Incident Response Trust Framework for Federated Identity (Sirtfi)
- Author
-
Nicole Harris, Tom Barton, Jim Basney, David Groep, Leif Johansson, David Kelsey, Scott Koranda, Romain Wartel, Ann West, and Hannah Short
- Subjects
Sirtfi ,Incident Response ,REFEDS - Abstract
This document identifies practices and attributes of organizations that may facilitate their participation in a trust framework called Sirtfi purposed to enable coordination of security incident response across federated organ izations.
- Published
- 2015
- Full Text
- View/download PDF
25. A transcriptomic approach to identify genes associated with wood density inPicea sitchensis
- Author
-
Steven G. Ralph, Joerg Bohlmann, Joan E. Cottrell, Nicole Harris, Patrick G. Stephenson, and Gail Taylor
- Subjects
Transcriptome ,Future studies ,Range (biology) ,Density analysis ,Botany ,Xylem ,Forestry ,Biology ,Cambium ,Natural variation ,Gene - Abstract
The demand for trees for industrial application is growing steadily and not expected to plateau for at least two decades; consequently, the supply of wood must increase to meet this need. One method for increasing yield without compromising land requirements is to modify wood density. The current study uses a transcriptomic approach to identify the genes associated with wood density that are likely to be of value in Sitka spruce (Picea sitchensis (Bong.) Carr.) breeding programmes. Following extensive wood density analysis from a Sitka field grown clonal trial, three detailed microarray studies were conducted to compare the transcriptome of cambium and xylem tissue from contrasting density clonal lines. Twenty-five genes exhibited differential expression, with up to 50-fold differences in expression observed, in at least two of the three microarray experiments, and this was verified using real-time polymerase chain reaction. Identified genes included those involved in cell wall synthesis, transcriptional regulation and plant pathogen defence functional categories. A wide range of processes influence wood density, but this study has identified potential regulators in these pathways. Future studies can now use this information to understand natural variation in wood density, and manipulate the expression of these genes to improve timber quality and yield.
- Published
- 2011
26. Would you eduID? Improving the user experience of federated access management
- Author
-
Nicole Harris
- Subjects
Resource (project management) ,User experience design ,business.industry ,Computer science ,Publishing ,Emerging technologies ,Information Dissemination ,Information access ,Library and Information Sciences ,Public relations ,business ,Access management - Abstract
New technologies bring new challenges. Nowhere is this more applicable than the rollout of federated access management in the scholarly publishing world. The UK Access Management Federation for Education and Research has been successful in recruiting publishers across the board, with recent announcements of compliance from IEEE and Wiley completing the picture for many institutional resource portfolios. However, the widespread implementation of the standardsâ€based approach to access management has given rise to a very specific problem – what do we call this thing we've started?
- Published
- 2010
27. The DiVLE Programme: outputs and outcomes
- Author
-
Nicole Harris
- Subjects
Knowledge management ,Higher education ,business.industry ,Computer science ,Educational technology ,Electronic media ,Library and Information Sciences ,Digital library ,Maturity (finance) ,Computer Science Applications ,World Wide Web ,Identification (information) ,Proof of concept ,Virtual learning environment ,business - Abstract
Purpose – The paper proposes to investigate the themes and findings of the ten‐month Linking Digital Libraries with Virtual Learning Environments (DiVLE) programme.Design/methodology/approach – The paper describes the themes and findings of the DiVLE programme.Findings – A key challenge in higher education is to reduce barriers to learning technologists and library staff working together. By investigating the potential connection between digital libraries and learning environments the programme contributed to this. Key findings were the need for consensus on and maturity of standards and identification of clear benefits for end‐users. Project outputs included tools, evaluations of commercial products and proof of concept trials.Originality/value – The paper provides useful information on the DiVLE programme.
- Published
- 2005
28. After Action Report or Body Bag with Letters in Latin Script
- Author
-
Alysia Nicole Harris
- Subjects
Cultural Studies ,Literature ,History ,Literature and Literary Theory ,Visual Arts and Performing Arts ,Action (philosophy) ,business.industry ,Latin script ,business - Published
- 2016
29. Mitochondria-Targeted Antioxidant Prevents Cardiac Dysfunction Induced by Tafazzin Gene Knockdown in Cardiac Myocytes
- Author
-
Jun Ren, Xianlin Han, Quan He, and Nicole Harris
- Subjects
Male ,Mitochondrial ROS ,Aging ,Article Subject ,Tafazzin ,Cardiomegaly ,Mitochondrion ,medicine.disease_cause ,Biochemistry ,Antioxidants ,Cyclic N-Oxides ,Mice ,chemistry.chemical_compound ,Adenosine Triphosphate ,medicine ,Cardiolipin ,Animals ,Myocyte ,lcsh:QH573-671 ,Gene knockdown ,biology ,lcsh:Cytology ,Barth syndrome ,Cell Biology ,General Medicine ,medicine.disease ,Molecular biology ,Mitochondria ,Cell biology ,Mice, Inbred C57BL ,chemistry ,Gene Knockdown Techniques ,Barth Syndrome ,biology.protein ,Reactive Oxygen Species ,Acyltransferases ,Oxidative stress ,Transcription Factors ,Research Article - Abstract
Tafazzin, a mitochondrial acyltransferase, plays an important role in cardiolipin side chain remodeling. Previous studies have shown that dysfunction of tafazzin reduces cardiolipin content, impairs mitochondrial function, and causes dilated cardiomyopathy in Barth syndrome. Reactive oxygen species (ROS) have been implicated in the development of cardiomyopathy and are also the obligated byproducts of mitochondria. We hypothesized that tafazzin knockdown increases ROS production from mitochondria, and a mitochondria-targeted antioxidant prevents tafazzin knockdown induced mitochondrial and cardiac dysfunction. We employed cardiac myocytes transduced with an adenovirus containing tafazzin shRNA as a model to investigate the effects of the mitochondrial antioxidant, mito-Tempo. Knocking down tafazzin decreased steady state levels of cardiolipin and increased mitochondrial ROS. Treatment of cardiac myocytes with mito-Tempo normalized tafazzin knockdown enhanced mitochondrial ROS production and cellular ATP decline. Mito-Tempo also significantly abrogated tafazzin knockdown induced cardiac hypertrophy, contractile dysfunction, and cell death. We conclude that mitochondria-targeted antioxidant prevents cardiac dysfunction induced by tafazzin gene knockdown in cardiac myocytes and suggest mito-Tempo as a potential therapeutic for Barth syndrome and other dilated cardiomyopathies resulting from mitochondrial oxidative stress.
- Published
- 2014
30. What is an ANGEL?
- Author
-
Nicole Harris
- Subjects
Formative assessment ,Knowledge management ,Summative assessment ,Process (engineering) ,business.industry ,Online learning ,Learning environment ,Sociology ,Library and Information Sciences ,business ,Computer Science Applications ,Web site - Abstract
The ANGEL (Authenticated Networked Guided Environment for Learning) project is funded under the JISC DNER 05/99 call. LITC’s involvement in the project includes responsibility for the initial formative evaluation, continuing dissemination and monitoring activities, and the summative evaluation of the system. This articled iscusses the formative evaluation process undertaken for the project by LITC between January and March 2001. The results of this process show that although users have a clear idea of the experience they wish to have within a learning environment, there are many concerns and problems that prevent institutions achieving this experience. Despite the fact that users consistently cite library resources as essential for online learning, they have no clear idea of how learning environments can be developed to improve delivery of resources. The full report of the evaluation can now be found on the ANGEL web site, together with the interview questions and results.
- Published
- 2001
31. Tafazzin knockdown interrupts cell cycle progression in cultured neonatal ventricular fibroblasts
- Author
-
Xianlin Han, Miao Wang, Quan He, and Nicole Harris
- Subjects
Cardiomyopathy, Dilated ,DNA Replication ,Time Factors ,Physiology ,Cardiolipins ,Heart Ventricles ,Tafazzin ,Down-Regulation ,AMP-Activated Protein Kinases ,Transfection ,Small hairpin RNA ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Adenosine Triphosphate ,Transduction, Genetic ,Physiology (medical) ,Cardiolipin ,medicine ,Animals ,Cells, Cultured ,Cell Proliferation ,Gene knockdown ,biology ,Cell Cycle ,Barth syndrome ,Cell cycle ,Fibroblasts ,medicine.disease ,Molecular biology ,Fibrosis ,Cell biology ,Rats ,Enzyme Activation ,chemistry ,Animals, Newborn ,Mitogen-activated protein kinase ,Gene Knockdown Techniques ,Barth Syndrome ,biology.protein ,RNA Interference ,Collagen ,Mitogen-Activated Protein Kinases ,Cardiology and Cardiovascular Medicine ,Reactive Oxygen Species ,Intracellular ,Acyltransferases ,Transcription Factors - Abstract
Mutation of the mitochondrial protein tafazzin causes dilated cardiomyopathy in Barth syndrome. Previous studies have shown that tafazzin knockdown promotes hypertrophy of neonatal cardiac myocytes. The current investigation was designed to show whether tafazzin knockdown affects cardiac fibroblast proliferation and collagen secretion, which contribute to fibrosis in dilated cardiomyopathy. In primary cultures of neonatal ventricular fibroblasts (NVFs) transduced with a tafazzin short hairpin RNA adenovirus, tafazzin knockdown increased production of reactive oxygen species and activation of mitogen-activated protein kinases and induced protein and DNA synthesis via cell cycle regulators. It also reduced intracellular ATP, activated AMPK, and caused multinucleation, hypertrophy, and enhanced collagen secretion. We concluded that tafazzin knockdown interrupts the NVF cell cycle and this in turn may contribute to fibrosis and dilated cardiomyopathy in Barth syndrome.
- Published
- 2013
32. Pancreatic Laceration
- Author
-
Nicole Harris, Denise Collins, and Michael D. Moffatt
- Subjects
medicine.medical_specialty ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Medicine ,Radiology, Nuclear Medicine and imaging ,Computed tomography ,Radiology ,business - Abstract
A case of pancreatic laceration in a child is presented. The complementary roles of computed tomography and sonography are compared.
- Published
- 1999
33. Abstract 2388: Deciphering the role of APE1 protein variants in disease etiology
- Author
-
Jennifer L. Illuzzi, Alexander C. Drohat, Nicole Harris, Brittney A. Manvilla, Daemyung Kim, Mengxia Li, and David M. Wilson
- Subjects
Premature aging ,chemistry.chemical_classification ,Genetics ,Cancer Research ,DNA ligase ,DNA damage ,Base excision repair ,Biology ,Molecular biology ,AP endonuclease ,XRCC1 ,Oncology ,chemistry ,DNA glycosylase ,biology.protein ,AP site - Abstract
Base excision repair (BER) is necessary for removal of DNA damage that has occurred from spontaneous decomposition, alkylation and oxidation. Defects in BER have been associated with cancer predisposition, neurodegeneration and premature aging. BER is initiated by a damage-specific DNA glycosylase that excises the damaged base, creating an apurinic/apyrimidinic (AP) site. The AP site is recognized by the multifunctional AP endonuclease 1 (APE1), which cleaves the phosphodiester backbone, producing a DNA strand break. DNA polymerase beta incorporates the correct nucleotide, and BER is completed via ligation by a protein complex of Ligase III and XRCC1. Like many BER proteins, APE1 is essential for survival, as deletion of both alleles in mice leads to embryonic lethality. We are pursuing the hypothesis that more mild reductions in APE1 activity will contribute to disease risk and development. To address this issue, we have engaged two strategies: (1) identification and characterization of APE1 missense mutations and (2) design and characterization of genetically-altered mutant human cell lines. In our first study, we have characterized eight APE1 variants found within the population or identified in endometrial cancer. Our studies reveal that while most of these proteins are normal for protein stability, biochemical activities, and intracellular localization, the endometrial cancer-associated variant Arg237Cys has decreased 3′-functions and AP-DNA binding. In our second study, we have created a heterozygous knockout HCT116 cell line, in which we have deleted one allele of APE1. The heterozygous knockout cells show a loss in AP endonuclease activity and are hypersensitive to DNA damaging drugs. Current cellular strategies are determining the essential nature of APE1 activity in HCT116 and other cell lines Citation Format: Jennifer Illuzzi, Nicole A. Harris, Brittney A. Manvilla, Daemyung Kim, Mengxia Li, Alexander C. Drohat, David M. Wilson. Deciphering the role of APE1 protein variants in disease etiology. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2388. doi:10.1158/1538-7445.AM2014-2388
- Published
- 2014
34. Functional Assessment of Population and Tumor-Associated APE1 Protein Variants
- Author
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Jennifer L. Illuzzi, Brittney A. Manvilla, David M. Wilson, Alexander C. Drohat, Daemyung Kim, Nicole Harris, and Mengxia Li
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DNA Repair ,lcsh:Medicine ,medicine.disease_cause ,Biochemistry ,Substrate Specificity ,Endonuclease ,Molecular cell biology ,0302 clinical medicine ,Neoplasms ,DNA-(Apurinic or Apyrimidinic Site) Lyase ,lcsh:Science ,Genetics ,0303 health sciences ,Mutation ,education.field_of_study ,Multidisciplinary ,biology ,Base excision repair ,Nucleic acids ,030220 oncology & carcinogenesis ,Female ,Research Article ,Exonuclease ,DNA repair ,Population ,Mutation, Missense ,03 medical and health sciences ,Cell Line, Tumor ,DNA-binding proteins ,Cancer Genetics ,medicine ,Humans ,AP site ,education ,Biology ,030304 developmental biology ,Evolutionary Biology ,Population Biology ,lcsh:R ,Proteins ,Computational Biology ,DNA ,DNA-(apurinic or apyrimidinic site) lyase ,Molecular biology ,Endometrial Neoplasms ,Amino Acid Substitution ,Genetic Polymorphism ,biology.protein ,lcsh:Q ,Population Genetics ,HeLa Cells - Abstract
Apurinic/apyrimidinic endonuclease 1 (APE1) is the predominant AP site repair enzyme in mammals. APE1 also maintains 3′–5′ exonuclease and 3′-repair activities, and regulates transcription factor DNA binding through its REF-1 function. Since complete or severe APE1 deficiency leads to embryonic lethality and cell death, it has been hypothesized that APE1 protein variants with slightly impaired function will contribute to disease etiology. Our data indicate that except for the endometrial cancer-associated APE1 variant R237C, the polymorphic variants Q51H, I64V and D148E, the rare population variants G241R, P311S and A317V, and the tumor-associated variant P112L exhibit normal thermodynamic stability of protein folding; abasic endonuclease, 3′–5′ exonuclease and REF-1 activities; coordination during the early steps of base excision repair; and intracellular distribution when expressed exogenously in HeLa cells. The R237C mutant displayed reduced AP-DNA complex stability, 3′–5′ exonuclease activity and 3′-damage processing. Re-sequencing of the exonic regions of APE1 uncovered no novel amino acid substitutions in the 60 cancer cell lines of the NCI-60 panel, or in HeLa or T98G cancer cell lines; only the common D148E and Q51H variants were observed. Our results indicate that APE1 missense mutations are seemingly rare and that the cancer-associated R237C variant may represent a reduced-function susceptibility allele.
- Published
- 2013
35. Mitochondria-Targeted Antioxidant Prevents Cardiac Dysfunction Induced by Tafazzin Gene Knockdown in Cardiac Myocytes.
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Quan He, Nicole Harris, Jun Ren, and Xianlin Han
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- 2014
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36. Factor analysis of the Adolescent Reinforcement Survey Schedule (ARSS) with college freshmen
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Elisabeth Chestnut, Robert V. Heckel, Joseph R. Cautela, Nicole Harris, and George R. Holmes
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education.field_of_study ,Acting out ,education ,Population ,Psychological intervention ,Human factors and ergonomics ,Poison control ,Social relation ,Developmental psychology ,Clinical Psychology ,Arts and Humanities (miscellaneous) ,Social skills ,Sibling ,Psychology ,Social psychology - Abstract
A factor analysis of the Adolescent Reinforcement Survey Schedule (ARSS) with a male and female college freshman (N = 231) population yielded 10 interpretable factors: Heterosexual Dating, Peer Interaction, Sibling/Family Interaction, Sexual Pleasure, Anti-School/Work, Leisure/Work Activity, Drugs/Acting Out, Entertainment/Social Activity, Home Avoidance, and Romantic Fantasy Activity. The first three factors are similar to a Positive Social interaction factor identified in a study that used the adult form of the Reinforcement Survey Schedule with a male and female college population. Suggestions are made from the ARSS responses of the college freshmen re interventions to facilitate social skill competency and the relationship aspects of sexual activity. A recommendation is made to replicate the current study with groups of early and mid-adolescents in order to study reinforces during different periods of adolescent development. Language: en
- Published
- 1987
37. Five QTL hotspots for yield in short rotation coppice bioenergy poplar: The Poplar Biomass Loci
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Nathaniel R. Street, Anne M. Rae, Gail Taylor, Kathryn M. Robinson, and Nicole Harris
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0106 biological sciences ,Plant Biology ,Biomass ,Plant Science ,Breeding ,01 natural sciences ,Coppicing ,lcsh:Botany ,2. Zero hunger ,0303 health sciences ,Genome ,Chromosome Mapping ,food and beverages ,lcsh:QK1-989 ,Populus ,Phenotype ,Zero Hunger ,Genome, Plant ,Research Article ,Crop and Pasture Production ,DNA, Plant ,Quantitative Trait Loci ,Plant Biology & Botany ,Crosses ,Quantitative trait locus ,Biology ,Genes, Plant ,Microbiology ,Genetic correlation ,Chromosomes, Plant ,Chromosomes ,Quantitative Trait ,03 medical and health sciences ,Quantitative Trait, Heritable ,Genetic ,Bioenergy ,Genetic variation ,Heritable ,Crosses, Genetic ,030304 developmental biology ,Hybrid ,Genetic Variation ,Plant ,DNA ,15. Life on land ,Genes ,Agronomy ,Short rotation coppice ,010606 plant biology & botany - Abstract
Background Concern over land use for non-food bioenergy crops requires breeding programmes that focus on producing biomass on the minimum amount of land that is economically-viable. To achieve this, the maximum potential yield per hectare is a key target for improvement. For long lived tree species, such as poplar, this requires an understanding of the traits that contribute to biomass production and their genetic control. An important aspect of this for long lived plants is an understanding of genetic interactions at different developmental stages, i.e. how genes or genetic regions impact on yield over time. Results QTL mapping identified regions of genetic control for biomass yield. We mapped consistent QTL across multiple coppice cycles and identified five robust QTL hotspots on linkage groups III, IV, X, XIV and XIX, calling these 'Poplar Biomass Loci' (PBL 1–5). In total 20% of the variation in final harvest biomass yield was explained by mapped QTL. We also investigated the genetic correlations between yield related traits to identify 'early diagnostic' indicators of yield showing that early biomass was a reasonable predictor of coppice yield and that leaf size, cell number and stem and sylleptic branch number were also valuable traits. Conclusion These findings provide insight into the genetic control of biomass production and correlation to 'early diagnostic' traits determining yield in poplar SRC for bioenergy. QTL hotspots serve as useful targets for directed breeding for improved biomass productivity that may also be relevant across additional poplar hybrids.
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38. Perceived Barriers to Career Self-Exploration for Adults with Learning Disabilities
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Harris, Alesha Nicole (Harris, Alesha Nicole)
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- Barriers, Career, Disabilities, Learning
- Abstract
Research regarding the career exploration process for adults with reading disabilities and ADHD who participate in Adult Basic Education (ABE) programs is limited. Due to a lack of career development resources in ABE programs, adults with reading disabilities and ADHD do not always have the opportunity to engage in career exploration activities that might help them make satisfying career decisions. In career development theory, self-determination is the capacity to identify personal goals and is considered crucial to overcoming barriers and making meaningful career choices. In the present study, a model was proposed and tested that examined self-determination as a mediator of the hypothesized relationships between perceived career and educational barriers and career development outcomes. Adults with reading disabilities and ADHD from ABE programs (N = 83) completed a demographic questionnaire and screening measures intended to classify them according to type of disability (i.e., reading, ADHD, and combined reading and ADHD). They also completed measures of perceived educational and career barriers, components of self-determination, and career self-efficacy. Multivariate multiple regression analyses were used to investigate hypotheses derived from the proposed model. The results revealed that experiences of perceived educational barriers, but not career barriers, were related to low levels of career decision-making self-efficacy and self-determination; the competence component of self-determination was associated with higher levels of career decision-making self-efficacy. Overall, the results suggested that self-determination partially mediated the relationship between perceived educational barriers and career decision-making self-efficacy. The findings indicate that, for ABE adults with reading disabilities and ADHD, having a sense of one’s own expertise is important for overcoming barriers and feeling confident in making career decisions. Discussions included methodological limitations and implications for practice and research.
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- 2016
39. Deliverable 4.1 Case Studies published
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Pals, Auke and Nicole Harris
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Privacy and Trust Enhancing Technologies ,Human Centric Internet - Abstract
This deliverable outlines the strategy on the approach to get case studies published for the NGI Trust projects. It provides details on the main objectives, selection, method of gathering the case studies and the communication channels. The case studies outline the importance and impact of the projects ensuring that research infrastructure managers, policy makers and funders, and other interested stakeholders rapidly become aware of the projects and impact of the NGI Trust project.
- Published
- 2021
- Full Text
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