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Information on the mesocosm and tracking setup, study populations and housing of fish, statistical analyses for estimating consistency of behaviours and figure correlating lab and mesocosm movement in lab-bred fish

During conditioning chemotherapy prior to allogeneic haematopoietic stem cell transplantation (HSCT), non-transferrin-bound iron and its chelatable form, labile plasma iron (LPI), regularly appear in the blood of patients at high levels of transferrin saturation (TfS). As these free iron species potentially favor infection and mediate transplantation-associated toxicities, chelation therapy could be an approach to improve outcome after transplantation. However, data addressing iron chelation in the immediate peritransplantation period are sparse. In this study, we investigated the influence of iron chelation with deferasirox during conditioning chemotherapy on the appearance of LPI, the incidence of infection and toxicities, and the tolerability of this treatment in the peritransplantation period. We conducted this single-center prospective observational study in 25 adults with iron overload (serum ferritin1000 µg/L) undergoing allogeneic HSCT after myeloablative busulfan-based conditioning chemotherapy. Patients received iron chelation with deferasirox (14 mg/kg) from the start of conditioning until day 3 post-transplantation. Iron parameters, including LPI, were obtained at the chelator's trough level daily until day 0 and then on days 4, 7, and 14. Data on infection (bacteremia or invasive fungal disease) and toxicity, as well as the tolerability of deferasirox, were collected until the end of the follow-up period on day 28. Data were analyzed descriptively. TfS levels exceeded 70% in median on 6 days (range, 4 to 10 days) and in 63.6% (range, 36.4% to 90.9%) of the samples per patient, although in 19 of 25 patients (76%), no elevated LPI values were detected during the intake of deferasirox despite high TfS levels. Only 6 patients (24%) showed mildly increased LPI values (≤0.5 units) during the intake of deferasirox, 3 of whom had presented with elevated LPI values before the start of conditioning. Deferasirox was well tolerated, and no aggravation of toxicities was observed. Infection occurred in 5 patients (20%), including 3 of the 6 patients with elevated LPI values despite chelation therapy. In the present study, we demonstrate that iron chelation with deferasirox safely suppresses the appearance of LPI and might decrease the incidence of infection, whereas the impact on transplantation-associated toxicities remains to be elucidated.

We present sea ice temperature and salinity data from first-year ice (FYI) and second-year ice (SYI) relevant to the temporal development of sea ice permeability and brine drainage efficiency from the early growth phase in October 2019 to the onset of spring warming in May 2020. Our dataset was collected in the central Arctic Ocean during the Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) Expedition in 2019 to 2020. MOSAiC was an international transpolar drift expedition in which the German icebreaker RV Polarstern anchored into an ice floe to gain new insights into Arctic climate over a full annual cycle. In October 2019, RV Polarstern moored to an ice floe in the Siberian sector of the Arctic at 85 degrees north and 137 degrees east to begin the drift towards the North Pole and the Fram Strait via the Transpolar Drift Stream. The data presented here were collected during the first three legs of the expedition, so all the coring activities took place on the same floe. The end dates of legs 1, 2, and 3 were 13 December, 24 February, and 4 June, respectively. The dataset contributed to a baseline study entitled, Deciphering the properties of different Arctic ice types during the growth phase of the MOSAiC floes: Implications for future studies. The study highlights downward directed gas pathways in FYI and SYI by inferring sea ice permeability and potential brine release from several time series of temperature and salinity measurements. The physical properties presented in this paper lay the foundation for subsequent analyses on actual gas contents measured in the ice cores, as well as air-ice and ice-ocean gas fluxes. Sea ice cores were collected with a Kovacs Mark II 9 cm diameter corer. To measure ice temperatures, about 4.5 cm deep holes were drilled into the core (intervals varied by site and leg) . The temperatures were measured by a digital thermometer within minutes after the cores were retrieved. The ice cores were placed into pre-labelled plastic sleeves sealed at the bottom end. The ice cores were transported to RV Polarstern and stored in a -20 degrees Celsius freezer. Each of the cores was sub-sampled, melted at room temperature, and processed for salinity within one or two days. The practical salinity was estimated by measuring the electrical conductivity and temperature of the melted samples using a WTW Cond 3151 salinometer equipped with a Tetra-Con 325 four-electrode conductivity cell. The practical salinity represents the the salinity estimated from the electrical conductivity of the solution. The dataset also contains derived variables, including sea ice density, brine volume fraction, and the Rayleigh number.

We present sea ice temperature and salinity data from first-year ice (FYI) and second-year ice (SYI) relevant to the temporal development of sea ice permeability and brine drainage efficiency from the early growth phase in October 2019 to the onset of spring warming in May 2020. Our dataset was collected in the central Arctic Ocean during the Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) Expedition in 2019 to 2020. MOSAiC was an international transpolar drift expedition in which the German icebreaker RV Polarstern anchored into an ice floe to gain new insights into Arctic climate over a full annual cycle. In October 2019, RV Polarstern moored to an ice floe in the Siberian sector of the Arctic at 85 degrees north and 137 degrees east to begin the drift towards the North Pole and the Fram Strait via the Transpolar Drift Stream. The data presented here were collected during the first three legs of the expedition, so all the coring activities took place on the same floe. The end dates of legs 1, 2, and 3 were 13 December, 24 February, and 4 June, respectively. The dataset contributed to a baseline study entitled, Deciphering the properties of different Arctic ice types during the growth phase of the MOSAiC floes: Implications for future studies. The study highlights downward directed gas pathways in FYI and SYI by inferring sea ice permeability and potential brine release from several time series of temperature and salinity measurements. The physical properties presented in this paper lay the foundation for subsequent analyses on actual gas contents measured in the ice cores, as well as air-ice and ice-ocean gas fluxes. Sea ice cores were collected with a Kovacs Mark II 9 cm diameter corer. To measure ice temperatures, about 4.5 cm deep holes were drilled into the core (intervals varied by site and leg) . The temperatures were measured by a digital thermometer within minutes after the cores were retrieved. The ice cores were placed into pre-labelled plastic sleeves sealed at the bottom end. The ice cores were transported to RV Polarstern and stored in a -20 degrees Celsius freezer. Each of the cores was sub-sampled, melted at room temperature, and processed for salinity within one or two days. The practical salinity was estimated by measuring the electrical conductivity and temperature of the melted samples using a WTW Cond 3151 salinometer equipped with a Tetra-Con 325 four-electrode conductivity cell. The practical salinity represents the the salinity estimated from the electrical conductivity of the solution. The dataset also contains derived variables, including sea ice density, brine volume fraction, and the Rayleigh number.

We present sea ice temperature and salinity data from first-year ice (FYI) and second-year ice (SYI) relevant to the temporal development of sea ice permeability and brine drainage efficiency from the early growth phase in October 2019 to the onset of spring warming in May 2020. Our dataset was collected in the central Arctic Ocean during the Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) Expedition in 2019 to 2020. MOSAiC was an international transpolar drift expedition in which the German icebreaker RV Polarstern anchored into an ice floe to gain new insights into Arctic climate over a full annual cycle. In October 2019, RV Polarstern moored to an ice floe in the Siberian sector of the Arctic at 85 degrees north and 137 degrees east to begin the drift towards the North Pole and the Fram Strait via the Transpolar Drift Stream. The data presented here were collected during the first three legs of the expedition, so all the coring activities took place on the same floe. The end dates of legs 1, 2, and 3 were 13 December, 24 February, and 4 June, respectively. The dataset contributed to a baseline study entitled, Deciphering the properties of different Arctic ice types during the growth phase of the MOSAiC floes: Implications for future studies. The study highlights downward directed gas pathways in FYI and SYI by inferring sea ice permeability and potential brine release from several time series of temperature and salinity measurements. The physical properties presented in this paper lay the foundation for subsequent analyses on actual gas contents measured in the ice cores, as well as air-ice and ice-ocean gas fluxes. Sea ice cores were collected with a Kovacs Mark II 9 cm diameter corer. To measure ice temperatures, about 4.5 cm deep holes were drilled into the core (intervals varied by site and leg) . The temperatures were measured by a digital thermometer within minutes after the cores were retrieved. The ice cores were placed into pre-labelled plastic sleeves sealed at the bottom end. The ice cores were transported to RV Polarstern and stored in a -20 degrees Celsius freezer. Each of the cores was sub-sampled, melted at room temperature, and processed for salinity within one or two days. The practical salinity was estimated by measuring the electrical conductivity and temperature of the melted samples using a WTW Cond 3151 salinometer equipped with a Tetra-Con 325 four-electrode conductivity cell. The practical salinity represents the the salinity estimated from the electrical conductivity of the solution. The dataset also contains derived variables, including sea ice density, brine volume fraction, and the Rayleigh number.

Da das Hochtemperaturreparaturlöten im Vakuum, neben dem Schweißen, bei der Fertigung und Reparatur geometrisch anspruchsvoller Bauteile immer mehr an Bedeutung gewinnt, ist es notwendig, Lötprozesse im Hinblick auf eine weitere Minimierung von Produktionskosten und Steigerung der Produktqualität mit dem Fokus einer ressourcenschonenden Fertigung weiterzuentwickeln. In der Regel werden Hochtemperaturlote in Form von Pasten, Tapes, Melt-Spun Folien und Pulvern hergestellt. Um Bauteile zu löten, wird das (Reparatur-)Lot meist händisch mittels Dosiernadel, Pinsel oder einem Spachtel auf die zu reparierenden Stellen des Bauteils aufgetragen. Durch die pulvermetallurgische Herstellung von Loten besteht weiterhin die Möglichkeit, diese durch thermisches Spritzen zu applizieren. Der Vorteil des Applizierens von Lotwerkstoffen durch thermisches Spritzen besteht darin, dass große Bereiche der zu fügenden oder zu reparierenden Teile endkonturnah beschichtet werden können. In dem vorliegenden Beitrag wird auf thermisch gespritzte Nickel- und Titanbasislote eingegangen. Typische Anwendungsgebiete sind der Maschinen- und Anlagenbau, der Automobilbau, die Biomedizintechnik sowie die Luft- und Raumfahrt. In dieser Arbeit wird gezeigt, wie das Reparaturlöten durch thermisches Spritzen von Turbinenschaufeln in einem Flugzeugtriebwerk eingesetzt werden kann. Die hier vorgestellte Technologie bringt technische und ökonomische Vorteile mit sich und ermöglicht die dem heutigen Stand der Technik entsprechende Prozesskette zur Reparatur von Turbinenschaufeln zu verkürzen.

Die Haftfestigkeit einer thermisch gespritzten Schicht auf dem Grundwerkstoff stellt ein wesentliches Qualitätsmerkmal dar und entscheidet unter anderem, ob der Verbund in der Praxis eingesetzt werden kann. In der industriellen Anwendung haben sich Strahl-prozesse für das Aufrauen und Aktivieren der Substratoberfläche etabliert. Aufgrund der verfahrenstypischen Nachteile und Einschränkungen, die die Strahlprozesse mit sich bringen, kommen zunehmend auch spanende Verfahren zur Oberflächenaktivierung zum Einsatz. Ein bereits bekanntes Beispiel hierfür ist das Einbringen eines Schwalben-schwanzprofils mit Schneidplatten in Aluminium-Zylinderlaufbahnen. Dieses For-schungsvorhaben fokussiert sich auf die Entwicklung innovativer Strukturierungen von Substratoberflächen als Alternative zum konventionellen Strahlspanen. In diesem Bei-trag wird gezeigt, dass die Verfahrenskombination Rändelfräsen und Umwalzen eine effiziente Methode für die Erzeugung von Oberflächenstrukturen zur formschlüssigen Substratanbindung thermisch gespritzter Schichten darstellt.

The ice-covered central Arctic Ocean is characterized by low primary productivity due to light and nutrient limitations. The recent reduction in ice cover has the potential to substantially increase phytoplankton primary production, but little is yet known about the fate of the ice-associated primary production and of the nutrient supply with increasing warming. This study presents results from the central Arctic Ocean collected during summer 2012, when sea-ice extent reached its lowest ever recorded since the onset of satellite observations. Net primary productivity (NPP) was measured in the water column, sea ice and melt ponds by 14CO2 uptake at different irradiances. Photosynthesis vs. irradiance (PI) curves were established in laboratory experiments and used to upscale measured NPP to the deep Eurasian Basin (north of 78° N) using the irradiance-based Central Arctic Ocean Primary Productivity (CAOPP) model. In addition, new annual production has been calculated from the seasonal nutrient drawdown in the mixed layer since last winter. Results show that ice algae can contribute up to 60% to primary production in the central Arctic Ocean at the end of the productive season (August–September). The ice-covered water column has lower NPP rates than open water due to light limitation in late summer. As indicated by the nutrient ratios in the euphotic zone, nitrate was limiting primary production in the deep Eurasian Basin close to the Laptev Sea area, while silicate was the main limiting nutrient at the ice margin near the Atlantic inflow. Although sea-ice cover was substantially reduced in 2012, total annual new production in the Eurasian Basin was 17 ± 7 Tg C yr−1, which is within the range of estimates of previous years. However, when adding the contribution by sub-ice algae, the annual production for the deep Eurasian Basin (north of 78° N) could double previous estimates for that area with a surplus of 16 Tg C yr−1. Our data suggest that sub-ice algae are an important component of the productivity in the ice-covered Eurasian Basin of the central Arctic Ocean. It remains an important question whether their contribution to productivity is on the rise with thinning ice, or whether it will decline due to overall sea-ice retreat and be replaced by phytoplankton.