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Your search keyword '"Nicolau‐Travers, M.‐L."' showing total 4 results
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4 results on '"Nicolau‐Travers, M.‐L."'

1. P477: PHENOTYPICALLY-DEFINED STAGES OF LEUKEMIA ARREST PREDICT MAIN DRIVER MUTATIONS SUBGROUPS, AND OUTCOME IN ACUTE MYELOID LEUKEMIA

Author

Vergez, F., primary, Largeaud, L., additional, Bertoli, S., additional, Nicolau-Travers, M.-L., additional, Rieu, J.-B., additional, Vergnolle, I., additional, Saland, E., additional, Sarry, A., additional, Tavitian, S., additional, Huguet, F., additional, Picard, M., additional, Vial, J.-P., additional, Lechevalier, N., additional, Bidet, A., additional, Dumas, P.-Y., additional, Pigneux, A., additional, Luquet, I., additional, Mansat-De Mas, V., additional, Delabesse, E., additional, Carroll, M., additional, Danet-Desnoyers, G., additional, Sarry, J.-E., additional, and Recher, C., additional

Published
2022
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2. Both plants Sebastiania chamaelea from Niger and Chrozophora senegalensis from Senegal used in African traditional medicine in malaria treatment share a same active principle

Author

Garcia-Alvarez, M.-C., primary, Moussa, I., additional, Njomnang Soh, P., additional, Nongonierma, R., additional, Abdoulaye, A., additional, Nicolau-Travers, M.-L., additional, Fabre, A., additional, Wdzieczak-Bakala, J., additional, Ahond, A., additional, Poupat, C., additional, Ikhiri, K., additional, and Benoit-Vical, F., additional

Published
2013
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4. From single-strand breaks to double-strand breaks during S-phase: a new mode of action of the Escherichia coli Cytolethal Distending Toxin.

Author

Fedor, Y., Vignard, J., Nicolau‐Travers, M.‐L., Boutet‐Robinet, E., Watrin, C., Salles, B., and Mirey, G.

Subjects
ESCHERICHIA coli, GENETIC toxicology, PATHOGENIC bacteria, CELL cycle, SINGLE-stranded DNA, GENETIC recombination
Abstract

The Cytolethal Distending Toxin ( CDT) is a genotoxin produced by several pathogenic bacteria. It is generally admitted that CDT induces double-strand breaks ( DSB) and cell cycle arrest in G2/ M-phase, in an ATM-dependent manner. Most of these results were obtained at high dose (over 1 μg ml−1) of CDT and late after treatment (8-24 h). We provide here evidence that the Escherichia coli CDT ( EcCDT) - at low dose (50 pg ml−1 or LD50) and early after treatment (3-6 h) - progressively induces DNA DSB, mostly in S-phase. DSB formation is related to the single-strand breaks induction by CDT, converted into DSB during the S-phase. We also show that homologous recombination is mobilized to these S-phase-associated DSB. This model unveils a new mechanism for CDT genotoxicity that may play a role in cells partly deficient in homologous recombination. [ABSTRACT FROM AUTHOR]

Published
2013
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