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1. Long-term administration of omeprazole in mice: a study of behavior, inflammatory, and oxidative stress alterations with focus on central nervous system

Author

Coelho, Dulce Maria Nascimento, Costa Júnior, Dilailson Carlos, da Silva, Daniel Moreira Alves, Alves, Ana Carolina Benício, Chaves, Raquell de Castro, Rebouças, Manoela de Oliveira, Valentim, José Tiago, de Oliveira, Andressa Alexandre, Sales, Iardja Stefane Lopes, Nicolau, Lucas Antonio Duarte, and de Sousa, Francisca Cléa Florenço

Published
2024
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3. Cardiotoxic and Cardioprotective Effects of Methylene Blue in the Animal Model of Cardiac Ischemia and Reperfusion.

Author

Fernandes Junior, Hezio Jadir, de Araújo, Erisvaldo Amarante, Machado Junior, José Antônio, Lutz Motta, Fabio Marinho, Guarize, Gabriela Ferrazzano, Cheng, Lucas Chen, Tantray, Junaid, Medeiros, Jand Venes Rolim, Nicolau, Lucas Antonio Duarte, Barbosa, Adriano Henrique Pereira, Caixeta, Adriano, Rocco, Isadora S., Guizilini, Solange, Pires-Oliveira, Marcelo, Taha, Murched Omar, Caricati-Neto, Afonso, Gomes, Walter José, Tallo, Fernando Sabia, and Menezes-Rodrigues, Francisco Sandro

Subjects
METHYLENE blue, VENTRICULAR arrhythmia, ARRHYTHMIA, CARDIOMYOPATHIES, LABORATORY rats, MYOCARDIAL reperfusion
Abstract

Background/Objectives: Treatment of patients with myocardial ischemic diseases crucially involves cardiac reperfusion (CR). However, oxidative stress and tissue lesions caused by CR may also lead to lethal complications, such as arrythmias and vasoplegic syndrome (VS). Although methylene blue (MB) has long been used to treat VS due to cardiac ischemia and reperfusion (CIR) and/or surgery because of its vascular effects, MB's effects on the heart are unclear. Therefore, we investigated the potential cardioprotective or arrhythmogenic effects of MB in an animal model of CIR. To this end, 12–16-week-old male Wistar rats were divided into four experimental groups: (a) rats subjected to SHAM surgery with no ischemia; (b) rats subjected to CIR and treated with a vehicle (SS + CIR); and (c) rats subjected to CIR and treated with 2 mg/kg i.v. MB before ischemia (MB + ISQ) or (d) after ischemia but before reperfusion (ISQ + MB). An ECG analysis was used to evaluate the incidence of ventricular arrhythmias (VAs), atrioventricular blocks (AVBs), and lethality (LET) resulting from CIR. After CIR, rat hearts were removed for histopathological analysis and lipid hydroperoxide (LH) measurements. Results: The incidence of VA, AVB, and LET was significantly increased in the MB + ISQ group (VA = 100%; AVB = 100%; LET = 100%) but significantly reduced in the ISQ + MB group (VA = 42.8%; AVB = 28.5%; LET = 21.4%) compared with the SS + CIR group (VA = 85.7%; AVB = 71.4%; LET = 64.2%). LH concentration was significantly reduced in both MB-treated groups, but myocardial injuries were increased only in the MB + ISQ group when compared with the SS + CIR group. Conclusions: These results indicate that MB produces a biphasic effect on CIR, with cardiotoxic effects when administered before cardiac ischemia and cardioprotective effects when administered after ischemia but before cardiac reperfusion. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Comprehensive analysis of gastrointestinal side effects in COVID-19 patients undergoing combined pharmacological treatment with azithromycin and hydroxychloroquine: a systematic review and network meta-analysis

Author

Pacheco, Gabriella, primary, Lopes, André Luis Fernandes, additional, Oliveira, Ana Patrícia de, additional, Corrêa, Wendson de Ribamar Machado, additional, Lima, Lucas Daniel Batista, additional, Souza, Marcellus Henrique Loiola Ponte de, additional, Teles, Ariel Soares, additional, Nicolau, Lucas Antonio Duarte, additional, and Medeiros, Jand Venes Rolim, additional

Published
2024
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5. Anti-inflammatory effect of l-cysteine (a semi-essential amino acid) on 5-FU-induced oral mucositis in hamsters

Author

Fonseca, Khetyma Moreira, Macda RodriguesCosta, Dionys, da Silva, Valderlon Freitas, de Carvalho, Jelson Lina, Oliveira, Ana Patrícia, de Melo Sousa, Francisca Beatriz, Lopes, André Luis Fernandes, da Silva Martins, Conceição, de Sousa Chaves, Letícia, Nicolau, Lucas Antonio Duarte, Cerqueira, Gilberto Santos, and Medeiros, Jand Venes Rolim

Published
2021
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7. Polysaccharide from Gracilaria caudata protects the human esophageal mucosal barrier: A differential topical effect and structural dependence

Author

Sales, Thiago Meneses Araújo Leite, Nicolau, Lucas Antonio Duarte, Rodrigues, Rhubens Levy Moreira, Nascimento, Renata Rocha, Paula, Suliana Mesquita, da Costa-Filho, Humberto Barbosa, Bezerra, Francisco Felipe, Santos, Gustavo Ramalho Cardoso, Barros, Francisco Clark Nogueira, Alencar, Poliana de Oliveira Cavalcante, Freitas, Ana Lúcia Ponte, Nobre-Souza, Miguel Ângelo, Santos, Armênio Aguiar, Sifrim, Daniel, Soares, Pedro Marcos Gomes, Silva, Renan Oliveira, and Souza, Marcellus Henrique Loiola Ponte

Published
2020
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8. Exploring the clinical relevance of “Angico Gum”: an effective biopolymer for topical protection of oesophageal mucosa in gastroesophageal reflux disease patients

Author

Bingana, Rudy Diavila, primary, Nicolau, Lucas Antonio Duarte, additional, Sales, Thiago Meneses Araújo Leite, additional, Paula, Suliana Mesquita, additional, do Carmo Neto, João Pedro, additional, Castro, Isabela Araújo Linhares, additional, Teixeira, Luiz Fernando Lopes Soares, additional, Franco, Alvaro Xavier, additional, Ribeiro, Fábio de Oliveira Silva, additional, de Paula, Regina Célia Monteiro, additional, Medeiros, Jand Venes Rolim, additional, da Silva, Durcilene Alves, additional, Sifrim, Daniel, additional, and Souza, Marcellus Henrique Loiola Ponte, additional

Published
2024
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9. Cardiotoxic Effects Produced by Omeprazole and Methylene Blue in an Animal Model of Cardiac Ischemia and Reperfusion and Potential Implications for the Pharmacological Strategy for Vasoplegic Syndrome

Author

de Araújo, Erisvaldo Amarante, primary, Tallo, Fernando Sabia, additional, Oliveira, Alex Sandro Felisberto, additional, Toghlobi, Gustavo Saad Silva El, additional, Arantes, Rafael Augusto, additional, Balsimelli, Rafael, additional, Kehrwald-Balsimelli, Bruno, additional, de Almeida Viana, Bianca Lorayne, additional, Matuda, Fernanda Sakata, additional, Nicolau, Lucas Antonio Duarte, additional, Medeiros, Jand Venes Rolim, additional, Caixeta, Adriano, additional, Taha, Murched Omar, additional, Gomes, Walter José, additional, Caricati-Neto, Afonso, additional, and Menezes-Rodrigues, Francisco Sandro, additional

Published
2024
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10. Potential Clinical Benefits And Probable Mechanisms of Action Promoted By A Nutraceutical Obtained By Fermentation And Rich In Β-Glucans And Amino Acids for Oncologic Patients

Author

Fernandes Junior, Hezio Jadir, primary, Tallo, Fernando Sabia, additional, Góes, Rafael Batman de, additional, Ferraz de Oliveira, Carolina Trabasso, additional, Nicolau, Lucas Antonio Duarte, additional, Arias, Alexia Nascimento, additional, Viana, Bianca Lorayne de Almeida, additional, and Menezes-Rodrigues, Francisco Sandro, additional

Published
2024
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11. Pharmacological Modulation of the Ca2+/cAMP/Adenosine Signaling in Cardiac Cells as a New Cardioprotective Strategy to Reduce Severe Arrhythmias in Myocardial Infarction

Author

Tallo, Fernando Sabia, primary, de Santana, Patricia Oliveira, additional, Pinto, Sandra Augusta Gordinho, additional, Lima, Rildo Yamaguti, additional, de Araújo, Erisvaldo Amarante, additional, Tavares, José Gustavo Padrão, additional, Pires-Oliveira, Marcelo, additional, Nicolau, Lucas Antonio Duarte, additional, Medeiros, Jand Venes Rolim, additional, Taha, Murched Omar, additional, David, André Ibrahim, additional, Luna-Filho, Bráulio, additional, Filho, Carlos Eduardo Braga, additional, Barbosa, Adriano Henrique Pereira, additional, Silva, Célia Maria Camelo, additional, Wanderley, Almir Gonçalves, additional, Caixeta, Adriano, additional, Caricati-Neto, Afonso, additional, and Menezes-Rodrigues, Francisco Sandro, additional

Published
2023
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12. The anti-inflammatory effects of N-methyl-(2S,4R)-trans-4-hydroxy-l-proline from Syderoxylon obtusifolium are related to its inhibition of TNF-alpha and inflammatory enzymes

Author

de Aquino, Pedro Everson Alexandre, Magalhães, Talita Rocha, Nicolau, Lucas Antônio Duarte, Leal, Luzia Kalyne A. Moreira, de Aquino, Nayara Coriolano, dos Santos, Sabrina Matias, Neves, Kelly Rose Tavares, Silveira, Edilberto Rocha, and Viana, Glauce Socorro de Barros

Published
2017
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13. Pharmacological Modulation of the Ca 2+ /cAMP/Adenosine Signaling in Cardiac Cells as a New Cardioprotective Strategy to Reduce Severe Arrhythmias in Myocardial Infarction.

Author

Tallo, Fernando Sabia, de Santana, Patricia Oliveira, Pinto, Sandra Augusta Gordinho, Lima, Rildo Yamaguti, de Araújo, Erisvaldo Amarante, Tavares, José Gustavo Padrão, Pires-Oliveira, Marcelo, Nicolau, Lucas Antonio Duarte, Medeiros, Jand Venes Rolim, Taha, Murched Omar, David, André Ibrahim, Luna-Filho, Bráulio, Filho, Carlos Eduardo Braga, Barbosa, Adriano Henrique Pereira, Silva, Célia Maria Camelo, Wanderley, Almir Gonçalves, Caixeta, Adriano, Caricati-Neto, Afonso, and Menezes-Rodrigues, Francisco Sandro

Subjects
ARRHYTHMIA, CALCIUM ions, HEART cells, MYOCARDIAL infarction, VENTRICULAR arrhythmia, ADENOSINES
Abstract

Acute myocardial infarction (AMI) is the main cause of morbidity and mortality worldwide and is characterized by severe and fatal arrhythmias induced by cardiac ischemia/reperfusion (CIR). However, the molecular mechanisms involved in these arrhythmias are still little understood. To investigate the cardioprotective role of the cardiac Ca2+/cAMP/adenosine signaling pathway in AMI, L-type Ca2+ channels (LTCC) were blocked with either nifedipine (NIF) or verapamil (VER), with or without A1-adenosine (ADO), receptors (A1R), antagonist (DPCPX), or cAMP efflux blocker probenecid (PROB), and the incidence of ventricular arrhythmias (VA), atrioventricular block (AVB), and lethality (LET) induced by CIR in rats was evaluated. VA, AVB and LET incidences were evaluated by ECG analysis and compared between control (CIR group) and intravenously treated 5 min before CIR with NIF 1, 10, and 30 mg/kg and VER 1 mg/kg in the presence or absence of PROB 100 mg/kg or DPCPX 100 µg/kg. The serum levels of cardiac injury biomarkers total creatine kinase (CK) and CK-MB were quantified. Both NIF and VER treatment were able to attenuate cardiac arrhythmias caused by CIR; however, these antiarrhythmic effects were abolished by pretreatment with PROB and DPCPX. The total serum CK and CK-MB were similar in all groups. These results indicate that the pharmacological modulation of Ca2+/cAMP/ADO in cardiac cells by means of attenuation of Ca2+ influx via LTCC and the activation of A1R by endogenous ADO could be a promising therapeutic strategy to reduce the incidence of severe and fatal arrhythmias caused by AMI in humans. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Pharmacological Modulation by Low Molecular Weight Heparin of Purinergic Signaling in Cardiac Cells Prevents Arrhythmia and Lethality Induced by Myocardial Infarction

Author

Filho, Carlos Eduardo Braga, primary, Barbosa, Adriano Henrique Pereira, additional, Nicolau, Lucas Antonio Duarte, additional, Medeiros, Jand Venes Rolim, additional, Pires-Oliveira, Marcelo, additional, dos Santos Póvoa, Rui Manuel, additional, Govato, Tânia Carmen Penãranda, additional, Júnior, Hézio Jadir Fernandes, additional, de Carvalho, Rafael Guzella, additional, Luna-Filho, Bráulio, additional, Sabia Tallo, Fernando, additional, de Araújo, Erisvaldo Amarante, additional, Padrão Tavares, José Gustavo, additional, Arida, Ricardo Mario, additional, Caricati-Neto, Afonso, additional, and Menezes-Rodrigues, Francisco Sandro, additional

Published
2023
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15. III Congresso Internacional de Estudantes e Profissionais da Saúde

Author

Lima, Aarão Filipe Ataídes, primary, Silva, Adalberto Socorro da, additional, Lima, Adão Francisco Leal, additional, Fernando, Adelson da Costa, additional, Reis, Adriana da Silva dos, additional, Lima, Adriana Machado, additional, Aguiar, Adriana Sousa Carvalho de, additional, Cunha, Adriano Matos, additional, Gomes, Adriele Sousa, additional, Ribeiro, Adrieli Raissa Lira, additional, Gomes, Adrielson Souza, additional, Araújo, Ágata Maria Xavier de, additional, Silva, Agnes Oliveira Costa e, additional, Moreira, Ailla Maria Sousa, additional, Sousa Junior, Airton Carlos Pereira de, additional, Conde Júnior, Aírton Mendes, additional, Vieira, Alaine Veras, additional, Albuquerque, Alana Aguiar, additional, Sousa, Alana Paulina de Moura, additional, Souza, Alana Rocha Tomaz de, additional, Desterro, Alana Silva do, additional, Almeida, Alane de Sousa Nascimento, additional, Madeiro, Alberto Pereira, additional, Santos, Alcimaria Silva dos, additional, Oliveira, Aldeídia Pereira de, additional, Rodrigues, Aldenora Maria Ximenes, additional, Cunha, Alefe Albuquerque, additional, Duarte, Alessandra Carvalho Nóbrega, additional, Costa, Alessandra de Araújo, additional, Chaves, Alessandro Cavalcante, additional, Martins, Alessandro Pereira, additional, Vieira, Alex Rodrigues Barão, additional, Liarte, Alexandra De Siqueira Cajado, additional, Amorim, Alexsandra da Silva, additional, Sousa, Alexsandra Vitório de, additional, Martins, Alice Maria Costa, additional, Lima, Alice Marques Moreira, additional, Soares, Alice Rosa, additional, Pereira, Aline Bianca do Nascimento, additional, Falcão, Aline de Sousa, additional, Justino, Aline de Sousa, additional, Santos, Aline Keuly Araújo dos, additional, Abreu, Aline Miranda, additional, Abreu, Aline Miranda de, additional, Mendes, Aline Paiva, additional, Ibiapina, Aline Raquel de Sousa, additional, Gomes, Aline Tavares, additional, Carneiro, Alinne Marília Moraes, additional, Santos, Álison Machado, additional, Fontenele, Allana Rhamayana Bonifácio, additional, Gomes, Alyce Irene da Silva, additional, Sousa, Alyne Alves de, additional, Almeida, Alyne Luz, additional, Alves, Alysson Santos, additional, Costa, Amanda Aguiar, additional, Ribeiro, Amanda Alves de Alencar, additional, Gonçalves, Amanda Christina Sousa, additional, Santos, Amanda Cristine Ferreira dos, additional, Ramalho, Amanda de Andrade Alencar, additional, Bezerra, Amanda de Araújo, additional, Mesquita, Amanda Jamyle Gomes, additional, Nascimento, Amanda Silva do, additional, Rodrigues, Amanda Souza, additional, Araújo, Amanda Victória Ferreira de, additional, Lima, Amanda Vieira, additional, Sarmento, Amanda Vieira, additional, Medeiros, Amanda Vitório Veras de, additional, Nascimento, Ana Beatriz Nogueira, additional, Bezerra, Ana Beatriz Norberto Nunes, additional, Moretão, Ana Beatriz Novaga, additional, Carvalho, Ana Carolina de Oliveira, additional, Vila, Ana Carolina Dias, additional, Oliveira, Ana Carolina Medeiros de, additional, Araújo, Ana Caroline de Sousa, additional, Santos, Ana Caroline Maia, additional, Costa, Ana Clara Coelho da, additional, Nascimento, Ana Clara dos Santos, additional, Nogueira, Ana Clara Tavares Dantas, additional, Rocha, Ana Cléa Silva da, additional, Araújo, Ana Cristina de, additional, Fialho, Ana Cristina Vasconcelos, additional, Costa, Ana Cristina Vieira da, additional, Ramos, Ana Elisa, additional, Sousa, Ana Flávia Aragão de, additional, Santos, Ana Gabriela Carvalho Bandeira, additional, Silva, Ana Gabriela Pereira da, additional, Melo, Ana Heloísa Moraes, additional, Monteiro, Ana Júlia dos Santos, additional, Magalhães, Ana Júlia Gomes, additional, Albuquerque, Ana Karine Carneiro de, additional, Maciel, Ana Karine Cavalcante, additional, Martins, Ana Kariny Galvão, additional, Carvalho, Ana Karolina da Silva, additional, Palhares, Ana Keyla da Silva, additional, Barbosa, Ana Larisse Santos, additional, Silva, Ana Laura Matias da, additional, Vasconcelos, Ana Leilania Freitas, additional, Carvalho, Ana Letícia de, additional, Santos, Ana Letícia Ferreira, additional, Marques, Ana Ligia Barros, additional, Oliveira, Ana Lívia Castelo Branco de, additional, Oliveira, Ana Lívia Paulino de, additional, Sousa, Ana Lívia Silva de, additional, Vasconcelos, Ana Lorena Marques de, additional, Silva, Ana Lourdes dos Reis, additional, Oliveira, Ana Patrícia de, additional, Araújo, Ana Patrícia dos Santos, additional, Alcantara, Ana Paula Guilherme, additional, Santos, Ana Paula Lima Menezes dos, additional, Pereira, Ana Paula Silva, additional, Honorato, Ana Raphaele Meneses, additional, Picanço, Ana Raquel Fernandes, additional, Farias, Ana Waléria Martins de, additional, Silva, Anabi Caroline da, additional, Santos, Ananda Priscila de Sena, additional, Silva, Anderson Almeida da, additional, Alelaf, André, additional, Dantas, André Jhonathan, additional, Lopes, André Luis Fernandes, additional, Bastos, André Pessoa Silva de, additional, Carvalho, André Rodrigues, additional, Rocha, André Sousa, additional, Moreira, Andréa Carvalho Araújo, additional, Brito, Andrea Nunes Mendes de, additional, Souza, Andréia Luíza da Silva, additional, Pinheiro, Andréia Santos de Carvalho, additional, Bravin, Andressa Alves Franco, additional, Pereira, Andressa Duarte, additional, Magalhães, Andressa Maria De Sousa, additional, Morais, Andressa Oliveira das Chagas, additional, Sabino, Andressa Ponte, additional, Silva, Andressa Trindade da, additional, Sobral, Andreza Gomes, additional, Araújo, Andreza Ketly da Silva, additional, Ribeiro, Andrezza Garcia Bandeira, additional, Barbosa, Ane Caroline de Carvalho, additional, Barbosa, Ane Kássia de Carvalho, additional, Rodrigues, Angela Maria Aguiar Albuquerque, additional, Sousa, Angela Vitório de, additional, Penha, Anna Julia Barbosa Silva, additional, Araújo, Anna Júlia Santos, additional, Portela, Anna Nayanna Escorcio de Aguiar, additional, Lima, Antonia Arlene, additional, Rodrigues, Antônia Carla Cardoso, additional, Torres, Antônia Cristiane Ferreira, additional, Sousa, Antônia Daniela Campos de, additional, Silva, Antonia Gerlane, additional, Timbó, Antônia Ingrid Freitas Martins, additional, Santos, Antonia Janaina Lira dos, additional, Fontenele, Antonia Jessica de Oliveira, additional, Santos, Antônia Laires da Silva, additional, Araújo, Antonia Larissa de, additional, Cardoso, Antônia Larissa de Miranda, additional, Silva, Antônia Liandra da, additional, Citó, Antônia Maria das Graças Lopes, additional, Martins, Antônia Marília Magalhães, additional, Oliveira, Antônia Natália da Silva, additional, Pereira, Antônia Sabrina de Matos, additional, Carvalho, Antônia Sílvia Souza, additional, Araújo, Antônia Vitória Elayne Carneiro, additional, Sousa, Antonielle Janara do Nascimento, additional, Carneiro, Antonielson Nascimento, additional, Costa Filho, Antônio Alberto Ibiapina, additional, Viegas, Antonio Alencar dos Santos, additional, Oliveira, Antonio Carlos Pereira de, additional, Costa, Antônio, additional, Oliveira, Antonio Emanuel Passos de Sousa, additional, Pereira, Antonio Francisco Machado, additional, Martins, Antonio Guilherme, additional, Carvalho Neto, Antonio Lopes de, additional, Amorim, Antônio Marcos Santos, additional, Santos Neto, Antonio Policarpo dos, additional, Ferreira Júnior, Antonio Rodrigues, additional, Souza, Antônio Tiago da Silva, additional, Araujo, Antônio Vinicius Vieira, additional, Macêdo, Antônio Vitor Barbosa, additional, Sousa, Antônio Wilson de, additional, Moura, Any Carolinne Rodrigues, additional, Nobre, Apolônia Stephany da Costa, additional, Santos, Ardilles Juan Carlos Alves dos, additional, Miranda, Arícia Gomes, additional, Ferreira, Ariédna da Hora, additional, Silva, Ariela Karollyny Santos, additional, Nogueira, Arlete Elleyn Paulino, additional, Cardoso, Arquimedes Cavalcante, additional, Gomes, Artur Barbosa, additional, Lima, Artur de Sousa, additional, Silva, Aryane Araújo, additional, Sousa, Aucilene Maria Costa de, additional, Alves, Augusto Cardoso, additional, Souza, Aurilene Soares de, additional, Mousinho, Ayana Rocha Pôrto, additional, Rodrigues, Ayane Araújo, additional, Figueira Junior, Aylton, additional, Rocha, Aymée Medeiros da, additional, Silva, Ayrton Geroncio, additional, Souza, Bárbara Costa de, additional, Pinheiro, Bárbara Rebeca de Macedo, additional, Vasconcelos, Beatriz Barros de, additional, Silva, Beatriz Cardoso da, additional, Sousa, Beatriz Costa de, additional, Oliveira, Beatriz de Carvalho, additional, Costa, Beatriz Pereira, additional, Rodrigues, Beatriz Veras, additional, Fonsêca, Belisa Maria Da Silva Melo, additional, Leite, Belize Rodrigues, additional, Martins, Benedita Meire Souza, additional, Freitas, Betânia de Jesus e Silva de Almendra, additional, Canedo, Bethania Luciana dos Santos Holanda, additional, Silva, Bianca Sabino Gomes, additional, Ferreira, Bianca Sáilan Ricardo Custódio, additional, Sousa, Bianca Santos de, additional, Oliveira, Bianca Soares de, additional, Andrade, Bianca Vasconcelos, additional, Bacelar, Brena Letícia da Silva, additional, Souza, Brenda Amanda Reinaldo de, additional, Souza, Brenda Silva de, additional, Falcão, Brenda Tavares, additional, Sousa, Brenno Carvalho, additional, Lima, Bruna Alcântara, additional, Madeira, Bruna Araújo, additional, Beltrão, Bruna Caroline Ribeiro, additional, Lopes, Bruna de Jesus, additional, Menezes, Bruna Fontenele de, additional, Bezerra, Bruna Lopes, additional, Lira, Bruna Rayelle Freitas, additional, Duque, Bruna Ribeiro, additional, Severo, Bruna Yasmim, additional, Gondinho, Brunna Verna Castro, additional, Machado, Bruno Abílio as Silva, additional, Maciel, Bruno Bezerra, additional, Gomes, Bruno da Silva, additional, Rodrigues, Caio San, additional, Nunes, Camila da Silva Lopes, additional, Ferreira, Camila Emanuelle da Silva, additional, Silva, Camila Gomes de Sousa, additional, Santos, Camila Lima Moraes dos, additional, Oliveira, Camila Martins de, additional, Vieira, Camila Milenna dos Santos, additional, Moraes, Camila Rocha de, additional, Marreiros, Camila Santos, additional, Freitas, Camila Siqueira Cronemberger, additional, Gonçalves, Camilla Almeida Moura Sales, additional, Branco, Camilla de Oliveira Castelo, additional, Sousa, Cândida Josélia de, additional, Viana, Carine Cristina Oliveira, additional, Leite, Carla Maria de Carvalho, additional, Silva, Carla Sousa da, additional, Freitas, Carla Vasconcelos, additional, Santos, Carlos Davi Ponte dos, additional, Pontes, Carlos Eduardo Bezerra, additional, Silva, Carlos Eduardo da, additional, Branco, Carlos Eduardo Rodrigues Castelo, additional, Lima, Carlos Henrique Ribeiro, additional, Costa, Carlos Vinícius Vale de Andrade, additional, Parente, Carolina Costa, additional, Saraiva, Caroline Rodrigues, additional, Batista, Carulina Cardoso, additional, Barros, Cassandra Mirtes de Andrade Rêgo, additional, Costa, Cecília Sousa, additional, Braga, Cecílio Soares Rodrigues, additional, Irene, Ceres Maria de Sousa, additional, Feitosa, Chistiane Mendes, additional, Costa, Chris Rejane da Cunha, additional, Beleza, Cinara Maria Feitosa, additional, Mendes, Cíntia Maria de Melo, additional, Andrade, Cintya Lopes Barroso, additional, Morais, Cirliane de Araújo, additional, Oliveira, Clara Cecilia Saboia de, additional, Albuquerque, Clara Luzia Cezario, additional, Fonseca, Clarisse Maria Barbosa, additional, Santos, Claudia Raissa da Silva, additional, Silva, Claudia Raissa Santos da, additional, Gonçalves, Cláudio Fernando Gomes, additional, Silva, Cleber de Sousa, additional, Sampaio, Cleia Araújo, additional, Matos, Cléssia Aparecida Alves de, additional, Pereira, Conceição de Maria Alves, additional, Carvalho, Crislane Carlos, additional, Ponte, Cristiana Moura da, additional, Carmo, Cristina dos Santos, additional, Nogueira, Crys Fernanda Carneiro, additional, Lima, Cynthia Cardozo, additional, Sousa, Cyntia Meneses de Sá, additional, Salles, Dafne Lopes, additional, Peres, Dalila Augusto, additional, Santos, Dalila Natiele de Jesus dos, additional, Maia, Dalma Matias, additional, Farias, Daniel Rodrigues de, additional, Soares, Daniel Victor Silva, additional, Silva, Daniela Delgado da, additional, Carvalho, Daniela Farias de, additional, Barros, Daniela França de, additional, Barros, Daniela Lígia Ribeiro, additional, Alexandre, Daniele, additional, Alves, Daniele Moreira, additional, Varela, Danielle Souza Silva, additional, Rios, Danielly Xavier, additional, Silva, Danyele Laiane Ribeiro da, additional, Costa, Darilena Silva, additional, Rodrigues, Darley Feitosa, additional, Feitosa, Darley Rodrigues, additional, Aragão, Davi Araújo, additional, Portela, Davi de Aguiar, additional, Ximenes, Davi Leonardo Soares, additional, Brito, Davi Silva, additional, Barros, David Cortez, additional, Schwarz, David Germano Gonçalves, additional, Araújo Júnior, David Gomes, additional, Moraes, Dayane Michelly Oliveira de, additional, Gomes, Dayse Rodrigues Ponte, additional, Ferreira, Débora Bruna Machado, additional, Cruz, Debora Denyse Rodrigues Pereira, additional, Oliveira, Débora Gonçalves de, additional, Freitas, Débora Joyce Nascimento, additional, Vasconcelos, Débora Linhares Militao, additional, Pereira, Débora Lorena Melo, additional, Almeida, Debora Regina Leitão, additional, Pereira, Débora Veras, additional, Jardilino, Deborah da Silva, additional, Moura, Deisyele Maria Souza, additional, Sousa, Dejayne Oliveira de, additional, Costa, Delciane de Sousa, additional, Soares, Deliane Dos Santos, additional, Almeida, Denise Evelyn Machado de, additional, Oliveira, Denise Hélen Imaculada Pereira de, additional, Silva, Denise Marques Costa Pereira da, additional, Moreira, Deyvid Augusto da Silva, additional, Araújo, Dhouglas Lucena, additional, Brito, Diana Damasceno de, additional, Silva, Diego Agripino Chagas, additional, Menezes, Diego da Silva, additional, Silva, Diego dos Santos, additional, Lima, Diellison Layson dos Santos, additional, Gomes, Diógenes Farias, additional, Rocha Filho, Disraeli Reis da, additional, Meira, Dorothy Emanuelly Acácio Vasconcellos, additional, Cruz, Duani Maria Gaspar da, additional, Silva, Eclesia Kauana dos Santos, additional, Cavalcante, Edla Camila da Conceição, additional, Fortes Júnior, Edmar José, additional, Gomes, Edna Lara Vasconcelos da Silva, additional, Ferreira, Eduana Maria da Silva, additional, Silva, Eduarda Cardoso e, additional, Marques, Eduardo Odonete, additional, Sousa, Eduardo Virgílio Medeiros de, additional, Vasconcelos, Edvânia Lopes, additional, Tupinambá, Elaine de Sales, additional, Santos, Elanna Batista Barbosa dos, additional, Santana, Elem Juliana, additional, Santana, Elem Juliana Silva, additional, Andrade, Elen Conceição Leal, additional, Rocha, Eliab Vasconcelos, additional, Oliveira, Eliany Nazaré, additional, Sousa, Eliete Oliveira de, additional, Rodrigues, Eliúde Melo de Aguiar, additional, Silva, Elizete da Rocha da, additional, Silva, Ellen Karem Rodrigues da, additional, Ribeiro, Eloah Costa de Sant Anna, additional, Magalhães, Emanuel Paula, additional, Pereira, Emanuela Oliveira, additional, Azevedo, Emanuelle Gomes, additional, Medeiros, Emerson Diógenes de, additional, Matos Neto, Emídio Marques de, additional, Silva, Emília do Nascimento, additional, Lima, Emily Queiroz, additional, Pinheiro, Enna Mara Oliveira, additional, Rodrigues, Erica Raquel Sampaio, additional, Oliveira, Erick Michell Bezerra, additional, Mouta, Érika Aguiar, additional, Costa, Ernesto Barros Amorim, additional, Barbosa, Estélio Silva, additional, Pereira, Ester Miranda, additional, Silva, Eucario Azevedo, additional, Almeida, Euclides Carvalho Meneses de, additional, Mesquita, Eudilene da Silva, additional, Santos, Eudilene Ponte dos, additional, Leal, Evaldo Sales, additional, Galvão, Evandra Marielly Leite Nogueira Freitas, additional, Fernandes, Evellyn Caroline Rodrigues, additional, Sousa, Evellyn Nizeth Batista Santos, additional, Marques, Evelyn Victória Gomes, additional, Alves, Even Herlany Pereira, additional, Santos, Fabiana Jéssica Lages dos, additional, Osternes, Fabiana Nayra Dantas, additional, Nogueira, Fábio Dias, additional, Tajra, Fábio Solon, additional, Farias, Fabíola Teles de Azevedo, additional, Silva, Fabrício da, additional, Monteiro, Fabrício Galvão, additional, Oliveira, Felipe Andrade de, additional, Braga, Felipe Melo, additional, Bezerra, Felipe Noronha Gomes, additional, Medeiros, Felype Hanns Alves de, additional, Amorim, Fernanda Cláudia Miranda, additional, Silva, Fernanda Lima e, additional, Martins, Fernanda Maciel Nogueira, additional, Silveira, Fernanda Maria Magalhães, additional, Aragão, Fernanda Moreira, additional, Farias, Fernanda Patrícia Araújo de, additional, Viana, Fernanda Rodrigues, additional, Costa, Fernanda Trajano, additional, Moura, Fernando Gabriel Batista de, additional, Silva, Fernando José de Morais, additional, Silva, Filipe Melo, additional, Chaves, Filipe Nobre, additional, Silva, Flavia Garcez Da, additional, Assunção, Flávio Bruno Rodrigues de, additional, Yoshioka, France Keiko Nascimento, additional, Sousa, Francileila Lago de, additional, Sousa, Francinaldo Lima, additional, Sousa, Francisca Beatriz de Melo, additional, Albuquerque, Francisca Bruna Vasconcelos, additional, Almeida, Francisca Candidja Ribeiro de, additional, Silva, Francisca Carmelinda Vasconcelos da, additional, Oliveira, Francisca Clementes de, additional, Albuquerque, Francisca Edilandia Cassimiro, additional, Lira, Francisca Fabiana Menezes, additional, Rocha, Francisca Gabriela Pinho, additional, Montesuma, Francisca Gomes, additional, Pereira, Francisca Juliana Soares, additional, Santos, Francisca Maria Alves dos, additional, Mota, Francisca Rosana Gonçalves, additional, Silva, Francisca Taysa de Abreu, additional, Oliveira Júnior, Francisco Antonio Borges de, additional, Araujo, Francisco Antonio Carneiro, additional, e Filho, Francisco Artur Silva, additional, Cunha, Francisco das Chagas de Souza, additional, Alves Neto, Francisco de Assis Batista, additional, Viana, Francisco dos Santos, additional, Martins, Francisco Eduardo Canuto, additional, Albuquerque, Francisco Estevão Araújo, additional, Pereira, Francisco Gilberto Fernandes, additional, Silva, Francisco Henrique Cardoso da, additional, Freire, Francisco Henrique Vale, additional, Martins, Francisco Isaque da Neves, additional, Araújo Filho, Francisco José de, additional, Melo, Francisco Noerdson Nascimento de, additional, Miranda Júnior, Francisco Pereira de, additional, Freitas, Francisco Ricardo Nascimento, additional, Silva, Francisco Timóteo Alves da, additional, Arruda, Francisco Vassiliepe Sousa, additional, Rocha, Francisco Vinicius Teles, additional, Lima, Francivaldo Sousa, additional, Hazime, Fuad Ahmad, additional, Carvalho Filho, Fugita Machado de, additional, Farias, Gable Araújo, additional, Sousa, Gabriel Albuquerque, additional, Magalhães, Gabriel Carneiro, additional, Bahia, Gabriel Fernando Mota, additional, Ferreira, Gabriel Luiz, additional, Menezes, Gabriel Maia, additional, Silva, Gabriel Martins da, additional, Telles, Gabriela Antônia Baquil, additional, Santos, Gabriela Bianchi dos, additional, Costa, Gabriela de Sousa Brasil Alves da, additional, Franco, Gabriela do Nascimento, additional, Lima, Gabriela Silva, additional, Araújo, Gabriela Veiga Macedo e, additional, Pacheco, Gabriella, additional, Sousa, Gabrielle Costa, additional, Pereira, Georje de Neiva, additional, Costa, Gessica da Silva, additional, Andrade, Gessiliane Alves de, additional, Farias, Gildeene Silva, additional, Oliveira Júnior, Gildenilson, additional, Silva Neto, Gilmar da Costa, additional, Dias, Giovana da Rocha Leal, additional, Pinto, Giovanny Rebouças, additional, Carvalho, Girleda Alcantara, additional, Rezende, Giselle Porto, additional, Porto, Giselle Rezende, additional, Sá, Giulia Santos de, additional, Henrique, Giuliano Araújo, additional, Duarte, Gladiston da Rocha, additional, Vale, Glauber Campo, additional, Viana, Glautemberg de Almeida, additional, Lima, Gleisson Ferreira, additional, Araújo, Gleyde Raiane de, additional, Amorim, Glícia Arcoverde Modesto, additional, Siqueira, Glória Cibele Bezerra, additional, Araújo, Glória Stéphany Silva de, additional, Oliveira, Guilherme Antônio Lopes de, additional, Oliveira, Guilherme Gomes de, additional, Cunha, Guilherme Monteiro, additional, Gouveia, Guilherme Pertinni de Morais, additional, Freitas, Hanna Camylle de Sousa, additional, Silva, Hedina Nunes, additional, Santos, Hélcio Silva dos, additional, Fleury, Heline Alvarenga, additional, Andrade, Hellen Cristina Pimentel, additional, Carlos, Hellen de Cássia Araújo Nunes, additional, Paz, Hellena Mireli Nascimento, additional, Pinheiro, Hellydeth Bezerra Cordeiro, additional, Araújo, Hemily Azevedo de, additional, Oliveira, Hemily Bruna Bezerra, additional, Sousa, Hendrick Nobre de, additional, Rosa, Henrique Danin Araújo, additional, Carvalho, Herica Emilia Félix de, additional, Miranda, Heytor Mapurunga de, additional, Silva, Hildnel Rodrigues Leal, additional, Cavalcante, Hinaira Brunna, additional, Queiroz, Hoberdânia Araújo, additional, Medeiros, Ialana Tereza Mendes, additional, Melo, Ian Lucas de Lima, additional, Martins, Iane Maria, additional, Lopes, Iane Rikaelle Coelho, additional, Melo, Iara Martins, additional, Martins, Iara Melo, additional, Rosa, Ideljane de Sena, additional, Rodrigues, Iellen Dantas Campos Verdes, additional, Carvalho, Igho Leonardo do Nascimento, additional, Carvalho, Ilaini Bruna Melo de, additional, Santos, Ilana Maria Maia dos, additional, Santos, Ilana Maria Maia, additional, Belfort, Ilka Kassandra Pereira, additional, Silva, Illana Maria Lages, additional, Sena, Inara Viviane de Oliveira, additional, Souza, Ingrid Castro de, additional, Macedo, Ingrid dos Santos, additional, Farias, Ingrid, additional, Silva, Ingrid Fátima Damasceno Pessoa, additional, Oliveira, Ingrid Kelly Morais, additional, Abreu, Ingrid Moura de, additional, Tajra, Ingrid, additional, Sousa Junior, Irineu de, additional, Branco, Irlana de Oliveira Castelo, additional, Silva, Isaac Gonçalves, additional, Martins, Isabel Cristina de Lira, additional, Lima, Isabel Fontenele Dias, additional, Aires, Isabel Oliveira, additional, Sousa, Isabele Alves de, additional, Rodrigues, Isabeli Tâmara do Nascimento Diniz, additional, Aguiar, Isadora Sousa, additional, Sousa, Isaura Danielli Borges de, additional, Barbosa, Italo Everton Bezerra, additional, Pires, Italo Macedo, additional, Sousa, Italo Nunes Arrais de, additional, Souza, Iure Leone Ribeiro, additional, Magalhães, Ivã Sales, additional, Silva, Ivila Rodrigues Celestino e, additional, Melo, Ivone Venâncio de, additional, Cronemberger, Izabel Herika Gomes Matias, additional, Amaral, Jackeline Vieira, additional, Oliveira, Jade Maria Albuquerque de, additional, Vieira, Jade Oliveira, additional, Mendes, Jadilson Rodrigues, additional, Reis, Jahaira Ribeiro, additional, Albuquerque, Jaiana Nascimento, additional, Aragão Neto, Jaime Conrado, additional, Variolo, Jaira Porta, additional, Rodrigues, Jakedna Azevedo do Nascimento, additional, Aguiar, Jamária Costa de, additional, Silva, James de Araújo, additional, Mendes, Jamila Davi, additional, Ferreira, Jamile Magalhães, additional, Silva, Jamille Rodrigues da, additional, Santos, Janaína Silva dos, additional, Medeiros, Jand Venes Rolim, additional, Penha, Jardeliny Correa da, additional, Araujo, Jeane Teixeira, additional, Rodrigues, Jefferson da Silva, additional, Costa, Jefferson Dantas da, additional, Nunes, Jefferson Torres, additional, Ribeiro, Jessé Soares Martins, additional, Moura, Jéssica Costa Brito Pacheco, additional, Brandão, Jessica Cunha, additional, Ferreira, Jéssica de Lima Rego, additional, Silva, Jéssica de Oliveira Gomes, additional, Lima, Jessica dos Santos, additional, Rodrigues, Jéssica Freitas, additional, Abreu, Jéssica Maria Chaves, additional, Abreu, Jéssica Mayra Silva, additional, Lourido, Jéssica Sabrina Rebelo, additional, Linhares, Jéssika Lorena Parente, additional, Aguiar, Jevanildo Paulino, additional, Aguiar, Jevanildo Paulino de, additional, Sales, Joaciara Nogueira, additional, Silva, Joana Germana Abreu da, additional, Figueira, Joana Nágila Ribeiro, additional, Ferreira, João Caio Silva Castro, additional, Santos, João Lucas Peres dos, additional, Pinto, João Lucas, additional, Silva, João Manoel dos Santos, additional, Ferreira Neto, João Marques, additional, Pereira, João Paulo dos Santos, additional, Ramos Junior, João Sales, additional, Chagas, João Victhor Sousa, additional, Silva, João Victor de Araújo, additional, Araújo, João Victor Silva, additional, Mota, João Victor Taumaturgo, additional, Evaristo, João Vitor das Chagas, additional, Oliveira Neto, Joaquim Guerra de, additional, Sousa, Jocsam Henrique Gomes de, additional, Remédios, Joelma de Cássia Pestana dos, additional, Sousa, Joerlison Rodrigues de, additional, Lira, John Arlley Sousa Pinho de, additional, Cavalcante, John Washington, additional, Jesus, Joilson Ramos, additional, Tajra, Jolie Elias, additional, Nascimento, Jonnatas Ferreira do, additional, Reis, Jordana Fonseca, additional, Siqueira, Jordânia Chaves de, additional, Morais, Jordanna Moreira de, additional, Martins, Jorddam Almondes, additional, Oliveira, Jorge Hiago da Silva, additional, Silva Junior, José Amauri da, additional, Gomes, José Augusto da Cunha, additional, Santos, José Carlos Teixeira dos, additional, Silva, José Francisco Cordeiro, additional, Albuquerque, José Henrique Moreira, additional, Hipólito, José Janailson, additional, Dias Neto, José João, additional, Nascimento, José Leandro do, additional, Mesquita, José Lucas Fechine, additional, Brito, José Nazareno Pearce Oliveira, additional, Costa, José Nicollas Carvalho, additional, Miranda Neto, José Pereira de, additional, Sousa, José Rúbem Mota de, additional, Sousa, José Samuel Teixeira de, additional, Cruz Júnior, José Simião da, additional, Carmo, Josiane dos Santos, additional, Maria, Josiane Fonteles de, additional, Silva, Josiane Santos, additional, Lopes, Josikelly Rodrigues, additional, Albuquerque, Josinyra Alyne, additional, Silva, Joyce Kelly de Oliveira e, additional, Aragão, Joyce Mazza Nunes, additional, Cunha, Joyce Pires Barros da, additional, Sousa, Jucelia Lima, additional, Manganeli, Júlia de Santis, additional, Silva, Julia Sousa da, additional, Pires, Juliana de Carvalho, additional, Vilanova, Juliana de Castro, additional, Dantas, Juliana de Meneses, additional, Cruz, Juliana do Nascimento da, additional, Machado, Juliana Leal Pinheiro, additional, Araújo, Julianna Sampaio de, additional, Silva Filho, Júlio Cesar de Castro e, additional, Lourenço, Jullya Alves, additional, Silva, Kaliane Lima do Bonfim, additional, Silva, Kaline Lorrany Mendes da, additional, Costa, Karen Evelyne Albano, additional, Viana, Karen Kauana Gramosa, additional, Silva, Karina de Kássia Silva e, additional, Silva, Karine Brito Beck da, additional, Oliveira, Karine da Silva, additional, Sousa, Karinna Alves de Amorim de, additional, Silva, Kárita Monielly da, additional, Aragão, Karla Lima, additional, Ripardo, Katharyna Khauane Brandão, additional, Silva, Katriane Carvalho da, additional, Martinelli, Katrini Guidolini, additional, Carvalho, Kauan Gustavo de, additional, Cunha, Kayron Rodrigo Ferreira, additional, Bezerra, Keila Cristiane Batista, additional, Marques, Keila Maria de Azevedo Ponte, additional, Hipólito, Keilane da Silva, additional, Sá, Kellen Miranda, additional, Santos, Kelly Pereira Rodrigues dos, additional, Teixeira, Kelly Sivocy Sampaio, additional, Moreira, Kellyane Folha Gois, additional, Brígido, Kelvyn Wendel Silva, additional, Fontenele, Kerolayne de Castro, additional, Silva, Késia de Moraes Dias da, additional, Ribeiro, Kevin Bruno Alves, additional, Silva, Kharlyanny Mendes, additional, Mesquita, Khauam Rodrigues, additional, Alves, Kleberson Brito, additional, Amorim, Kleyton Wesley Ferreira de, additional, Campos, Klicia Rufino Ramos Madeira, additional, Santos, Kyvia Naysis de Araujo, additional, Araújo, Laécio de Lima, additional, Santos, Laiane de Abreu, additional, Pereira, Laiane Fernandes, additional, Oliveira, Lairton Batista de, additional, Almeida, Laís Sousa Santos de, additional, Magalhães, Laisa Graziely Araújo, additional, Ribeiro, Laisa Maria dos Santos, additional, Lopes, Laisa Silva, additional, Leocadio, Laiza Karone Alves, additional, Lima, Lara Fernanda Carlos, additional, Silva, Lara Maria da, additional, Moura, Lara Nicolle de Paula Frota, additional, Monteiro, Larissa Cecy Lustosa do Rêgo, additional, Barbosa, Larissa Colares de Almeida, additional, Miranda, Larissa de Sousa, additional, Martins, Larissa Helen Portela, additional, Torres, Larissa Ivna da Costa, additional, Barros, Larissa Tainara Santos, additional, Gomes, Larisse da Silva, additional, Pontes, Larisse Damasceno, additional, Barros, Larisse Kelly Silva, additional, Silva, Larissi Ellen Sousa da, additional, Araújo, Larruama Soares Figueiredo de, additional, Damaceno, Latipha Lauanny Pereira, additional, Silva, Laura Raquel Costa Ferreira da, additional, Feitosa, Lauro César Soares, additional, Carvalho, Layane Santos de, additional, Pires, Lays Fernanda Sousa, additional, Costa, Laysla Araújo, additional, Costa, Laysla de Araújo, additional, Silva, Laysla Grazieli Lopes da, additional, Montes, Ledayellen de Andrade, additional, Coelho, Leilah Monte, additional, Carnib, Lennara Antônia de Alencar, additional, Lima, Leonardo Emmanuel de Medeiros, additional, Rodrigues, Leonel Marques, additional, Evangelista, Leones Fernandes, additional, Silva, Letícia Alves Rodrigues, additional, Chaves, Letícia de Sousa, additional, Sousa, Letícia Emilly Mesquita de, additional, Sousa, Letícia Graziela Lopes França, additional, Nascimento, Letícia Hélida Santos, additional, Lima, Letícia Mara Cavalcante, additional, Oliveira, Letícia Michelly da Silva Nunes, additional, Ramos, Letícia Moreira, additional, Mota, Leticia Muniz Chaves, additional, Silva, Letícia Pereira da, additional, Santos, Letícia Teixeira, additional, Teixeira, Leticya Sousa, additional, Adriano, Leyla Gerlane de Oliveira, additional, Barbosa, Liana Dantas da Costa e Silva, additional, Nobre, Lidia Lopes, additional, Silva, Lielma Carla Chagas da, additional, Avelino, Lígia Maria dos Santos, additional, Moraes, Lilian Machado Vilarinho de, additional, Fortaleza, Lilian Melo de Miranda, additional, Marques, Liliane Maria da Costa Rabelo, additional, Silva, Liridy Bruna Rodrigues da, additional, Serra, Lívia Reverdosa Castro, additional, Costa, Livya Monte, additional, Araújo, Lizandra Melo de, additional, Ramos, Lizandra Mesquita, additional, Brasil, Lorena Uchôa Portela Veloso, additional, Mesquita, Lorrane Pinto de, additional, Oliveira, Lourival Veras de, additional, Oliveira, Luan de Sousa, additional, Teixeira, Luan Gomes, additional, Souza, Luan Kelves Miranda de, additional, Silva, Luana Antunes da, additional, Guedelho, Luana Araújo, additional, Farias, Luana Azevedo, additional, Silva, Luana Bezerra, additional, Marques, Luana de Souza, additional, Ferreira, Luana Gabrielle de França, additional, Rodrigues, Luana Lorena Silva, additional, Meneses, Luana Nayra Coutinho de, additional, Rodrigues, Luana Paula, additional, Nascimento, Luana Raphaelle Rodrigues do, additional, Monteiro, Luana Tayna de Oliveira, additional, Belém, Luanda Carla Oliveira, additional, Araújo, Luann Victor Rabêlo, additional, Santos, Luanna Larissa Silva, additional, Ramos, Luanna Martins, additional, Cantanhede, Lucas Antônio de Oliveira, additional, Nicolau, Lucas Antonio Duarte, additional, Franco, Lucas Carreira, additional, Martins, Lucas de Oliveira, additional, Carvalho, Lucas de Sá, additional, Costa, Lucas Manoel Oliveira, additional, Santos, Lucas Pereira dos, additional, Oliveira, Lucas Sabino, additional, Brito, Lúcia Sergina, additional, Brandão, Luciana Camila dos Santos, additional, Ribeiro, Luciana Fujiwara Aguiar, additional, Arruda, Luciana Sousa, additional, Silva, Lucília da Costa, additional, Araújo, Lucineide Carvalho de, additional, Fonseca, Luis Eduardo Valente Amorim, additional, Mascarenhas, Luís Henrique Maciel Nogueira, additional, Silva, Luís Paulo Teixeira da, additional, Pires, Luis Portela, additional, Salazar Júnior, Luís Ricardo, additional, Araújo, Luiz Allan de Lima, additional, Oliveira, Luiz Augusto de, additional, Teixeira, Luiz Fernando Lopes Soares, additional, Silva Neto, Luiz Gomes da, additional, Cunha, Luiz Guilherme de Sousa, additional, Pereira, Luiz Henrique Lola, additional, Costa, Luiza Mota Barros, additional, Linhares, Luiza Nascimento Soares, additional, Viana, Luzia Helena Silva Chaves, additional, Maciel, Luziana da Silva, additional, Ribeiro, Lyanna Rodrigues, additional, Souza, Lyvia Maria Paiva de, additional, Costa, Mac Dionys Rodrigues da, additional, Silva, Maiara Sales, additional, Marques, Maicon Jhones de Oliveira, additional, Lino, Maísa Ravenna Beleza, additional, Souza Filho, Manoel Dias de, additional, Coelho, Manoel Victor Carvalho, additional, Coelho, Manoel Victor, additional, Pinheiro, Mara Cibelly da Silva, additional, Cardoso, Maraysa Costa Vieira, additional, Gualter, Marcela Pereira, additional, Ribeiro, Marcela Tavares Silva, additional, Torres, Marcella Matias, additional, Vasconcelos, Marcelo Araújo de, additional, Ribeiro, Marcelo Barbosa, additional, Duarte, Marcelo Brandão, additional, Filgueiras, Marcelo de Carvalho, additional, Souza, Marcelo Franco e, additional, Fernandes, Márcia Astrês, additional, Vieira, Márcia Luciane, additional, Moraes, Márcio Venício Alcantara de, additional, Sá, Marcos Alexandre Ribeiro, additional, Guimarães, Marcos Carducci, additional, Lima, Marcos Prado, additional, Ribeiro, Marcus Vinícius Saldanha, additional, Mendes, Maria Abilene Rodrigues, additional, Silva, Maria Adelane Monteiro da, additional, Silva, Maria Andhiara Kaele Feitosa, additional, Facundo, Maria Andréia da Costa, additional, Silva, Maria Aparecida Soarigues da, additional, Carvalho, Maria Ariane Silva, additional, Sá, Maria Augusta Amorim Franco de, additional, Araújo, Maria Auxiliadora Ferreira, additional, Lopes, Maria Cândida de Almeida, additional, Santos, Maria Cecília Kosmala dos, additional, Morais, Maria Clara de Sousa, additional, Feitosa, Maria Clara Duarte, additional, Silva, Maria Clara Maciel da, additional, Learte, Maria Cláudia Pereira, additional, Reis, Maria Cristina Nunes Madeira, additional, Costa, Maria Da Conceição Cardoso da, additional, Carvalho, Maria da Conceição de Oliveira, additional, Alvarenga, Maria da Conceição Pinto, additional, Fortuna, Maria Daianne Lopes, additional, Sousa, Maria das Dores Nascimento, additional, Ferreira, Maria de Jesus Silva, additional, Rocha, Maria Debora Rodrigues da, additional, Martins, Maria do Carmo de Carvalho e, additional, Silva, Maria do Livramento Lima da, additional, Bandeira, Maria do Rosário Lopes, additional, Souza, Maria Doralice Lima, additional, Albuquerque, Maria Edilândia Ernesto de, additional, Silva, Maria Edilane Paiva da, additional, Moura, Maria Edileuza Soures, additional, Rabêlo, Maria Eduarda Almeida, additional, Delfino, Maria Eduarda de Jesus, additional, Santos, Maria Eduarda de Oliveira dos, additional, Silva, Maria Eduarda Pereira Passos da, additional, Mourão, Maria Eduarda Santiago, additional, Luz, Maria Eduarda Silva Siqueira da, additional, Albuquerque, Maria Eliane de Paulo, additional, Nascimento, Maria Eline dos Santos, additional, Santos, Maria Emanuele do Rego, additional, Morais, Maria Francisca Soares de, additional, Alves, Maria Gabriela Moreira, additional, Ribeiro, Maria Gabriela Santos, additional, Silva, Maria Gilselani Pereira da, additional, Silva, Maria Gislene Santos, additional, Carmo, Maria Isabel dos Santos, additional, Brito, Maria Isabelle, additional, Guerra, Maria Ivone Mendes Benigno, additional, Rocha, Maria Izabel Félix, additional, Oliveira, Maria Jeyza Lima, additional, Catunda, Maria Júlia dos Santos, additional, Lages, Maria Karolinne Araújo Barbosa, additional, Lourenço, Maria Leilah Monte Coelho, additional, Cavalcante, Maria Liana Rodrigues, additional, Pereira, Maria Liliane Luciano, additional, Sousa, Maria Luana de Moura, additional, Santiago, Maria Luci Esteves, additional, Frota, Maria Madalena Cardoso da, additional, Cavalcante, Maria Rabechy Portela, additional, Rego, Maria Rosiane Lopes, additional, Moreira, Maria Rosiany Sousa, additional, Resende, Maria Sara Sousa, additional, Barros, Maria Seiane Farias, additional, Linhares, Maria Socorro Carneiro, additional, Dias, Maria Socorro de Araújo, additional, Araújo, Maria Vanderline Pimenta, additional, Correia, Maria Vanessa Alves, additional, Adeodato, Maria Vilma Dias, additional, Santos, Maria Vitória de Sousa, additional, Silva, Maria Yanaelle Sobrinho, additional, Santos, Mariana Avelino dos, additional, Silva, Mariana Clara Borges da, additional, Ferreira, Mariana da Silva, additional, Soares, Mariana de Morais, additional, Oliveira, Mariana Lima, additional, Alves, Mariana Loiola, additional, Mesquita, Mariana Morais, additional, Rocha, Mariana Rodrigues da, additional, Holanda, Mariana Souza Bezerra, additional, Magalhães, Mariane, additional, Pereira, Marianne dos Santos, additional, Fernandes, Marília Nunes, additional, Alves, Marina Daniele Sousa, additional, Sousa, Marina Ferreira de, additional, Borges, Marina Rodrigues, additional, Alves, Marisa Carla Silveira, additional, Reis, Markilene Rodrigues dos, additional, Viana, Marlison Wesley Miranda, additional, Fonteles, Marta Maria França, additional, Araújo, Martinilsa Rodrigues, additional, Martins, Márvilla Pinto, additional, Bandeira, Mary Anne Medeiros, additional, Amaral, Mateus Cardoso do, additional, Silva, Mateus dos Santos da, additional, Silva, Mateus Edson da, additional, Oliveira, Mateus Veras Pessoa de, additional, Bezerra, Matheus Antonio Braga, additional, Lemos, Matheus Henrique da Silva, additional, Costa, Matheus Monteiro, additional, Oliveira, Matheus Pedrosa de, additional, Lemos, Matheus Sam dos Santos, additional, Machado, Matheus Sousa, additional, Conceição, Maura Cristina Silva da, additional, Marques, Mayane Cristina Pereira, additional, Rodrigues, Mayara Joyce Ferreira Ribeiro, additional, Araújo, Mayara Karoline Diniz, additional, Carvalho, Mayara Kelle Rodrigues de, additional, Ponte, Mayara Kerly Coelho, additional, Almeida, Mayara Póvoa dos Santos, additional, Almeida, Maycon Campos de, additional, Praça, Mayla Chaves, additional, Mesquita, Mayrla Karen Rodrigues, additional, Ribeiro, Mayssa Jane Dias, additional, Silva, Meire Maria de Sousa e, additional, Silva, Meiryellen Castelo Branco Rodrigues da, additional, Feitosa, Melice Barbosa Oliveira, additional, Leite, Mérssia Maria do Nascimento, additional, Monteiro, Michael Henrique Araújo, additional, Cruz, Michelle de Sousa, additional, Torres, Michelle Vicente, additional, Moura, Michely Laiany Vieira, additional, Ribeiro, Miguel Victor Teles, additional, Soares, Mikaella de Cerqueira, additional, Barbosa, Milckea Hellene de Sousa Araújo, additional, Nazario, Mileide de Jesus Novais, additional, Silva, Milka Borges da, additional, Silva, Mirella Costa Gomes da, additional, Santos, Mirelly Suenha de Araújo Costa, additional, Frota, Mirna Albuquerque, additional, Albuquerque, Mirna Frota, additional, Moita, Monalisa Sá Albuquerque, additional, Carneiro, Monalyza Pontes, additional, Clemente, Mônica Cecília Fernandes, additional, Santana, Mônica Leila Portela de, additional, Lima, Mykaelle Soares, additional, Silva, Mylenna Soares, additional, Turbano, Myrella Evelyn Nunes, additional, Queiroz, Myrlane Matias da Silva, additional, Carvalho, Naara Quaresma de, additional, Sousa, Nádja Sileny de, additional, Penha, Naiane dos Santos da, additional, Brito, Naiara do Nascimento, additional, Gomes, Naiara Dutra Barroso, additional, Araújo, Naila Juliana Ferreira, additional, Sousa, Nájda Sileny de, additional, Barbosa, Nanielle Silva, additional, Barros, Nara Vanessa dos Anjos, additional, Silva, Naryelly Stelyte Gomes da, additional, Cardoso, Natália Carvalho, additional, Machado, Natália Fernandes, additional, Ribeiro, Natalia Kisha Teixeira, additional, Sousa, Natasha Luísa da Silva, additional, Santos, Nathalie Carvalho dos, additional, Rocha, Nayara Lourenço, additional, Sousa, Nayara Regina Silva, additional, Carvalho, Nayara Rodrigues de, additional, Araújo, Nayrana Kelly de Sousa, additional, Sousa, Neilma Oliveira de, additional, Freitas, Neíres Alves de, additional, Batista, Nelson Jorge Carvalho, additional, Ripardo, Niele Duarte, additional, Tajra, Nilsa Araújo, additional, Romero, Nirla Rodrigues, additional, Cruz, Noeli Aquino da, additional, Castro, Noely Lorene dos Santos de, additional, Brito, Odézio Damasceno, additional, Sampaio, Odiomara Telésforo, additional, Batista, Olívia Simôa Chaves, additional, Cruz, Pablo Nascimento, additional, Rodrigues, Paloma de Vasconcelos, additional, Brito, Paloma Fernanda Borges de, additional, Farias, Paloma Ramos Meneses Rangel, additional, Oliveira, Pamela Souza da Silva, additional, Cavalcanti, Patrícia de Azevedo Lemos, additional, Viana, Patrícia Ferreira de Sousa, additional, Grun, Patricia Narguis, additional, Araújo, Patricya Rayane Azevedo Alves, additional, Rocha, Paul Symon Ribeiro, additional, Rocha, Paula Daniela de Sousa, additional, Honorato, Paula Eduarda Oliveira, additional, Brito, Paula Fontenele, additional, Mendes, Paula Rivele Gomes Sousa, additional, Florêncio, Paulo César Monteiro, additional, Sousa, Paulo César Pereira de, additional, Silva, Paulo Gregório Nascimento da, additional, Aquino, Paulo Henrique Costa de, additional, Gomes, Paulo Roberto Carneiro, additional, Borges, Paulo Roberto Pereira, additional, Moreira, Paulo Victor Soares, additional, Lima, Pedro Henrique da Costa, additional, Costa, Pedro Henrique do Nascimento, additional, Holanda, Pedro Henrique Fréres, additional, Santos, Pedro Henrique Leocádio de Sousa, additional, Silva, Pedro Henrique Sousa da, additional, Santos, Pedro Isaque Inácio dos, additional, Santos, Pedro Victor Sousa dos, additional, Furtado, Pedro Vitor Oliveira Silva, additional, Hall, Peter Richard, additional, Goiano, Pétterson Danilo de Oliveira Lima, additional, Brito, Poliana Veras, additional, Brito, Poliana Veras de, additional, Brito, Polianna Fontenele, additional, Araújo, Pollyana Rocha, additional, Silva, Polyana Cabral da, additional, Mendes, Polyana Norberta, additional, Feitosa, Priscila de Souza, additional, Souto, Priscila Maria Vieira, additional, Lopes, Priscila Ruth Moita, additional, Cardoso, Rafael Vinicius Lopes, additional, Vilanova, Rafaela Ferreira, additional, Sabino, Rafaele Lohane dos Santos, additional, Moura, Raimunda Alves da Costa de, additional, Lima Neto, Raimundo Graças Almeida, additional, Soares, Raimundo José do Nascimento, additional, Menezes, Ramon Róseo Paula Pessoa Bezerra de, additional, Gomes, Raniele Cimara da Conceição, additional, Gomes, Rannatricia Sampaio, additional, Machado, Ranyelison Silva, additional, Silva, Raphaele Maria Almeida, additional, Ziesemer, Ravena Petra Mororó, additional, Nascimento, Ravena Silva do, additional, Brito, Rayane Sousa de, additional, Brito, Rayanne Teixeira, additional, Costa, Raylla Silva, additional, Silva, Rayllany Nayra Araújo da, additional, Coutinho, Raylson Daniel Pimentel, additional, Batista, Rayslane Sabrina Avelino, additional, Silva, Rayssa Maria de Sousa, additional, Santos, Rebeca Barbosa dos, additional, Bernardes, Regiane Sablina Almeida, additional, Barbosa, Regisson Cauann Teixeira, additional, Queiroz, Reijane Mara Pinheiro, additional, Reis, Renandro de Carvalho, additional, Carvalho, Renandro Reis de, additional, Pinheiro, Renata Batista dos Santos, additional, Maia, Renata Carvalho Lopes, additional, Alves, Renata de Sousa, additional, Sales, Renata de Sousa Costa, additional, Fontenele, Renata Kristine Passos, additional, Santos, Renata Melo dos, additional, Beltrão, Renata Paula Lima, additional, Martins, Renata Sabóia, additional, Costa, Renata Sousa, additional, Silva, Renata Souza da, additional, Sampaio, Renato da Costa e Silva Rebelo, additional, Anjos, Renato Feitosa dos, additional, Santos, Renato Mendes dos, additional, Souza, Rennan Lima de, additional, Andrade, Ricardo Henrique Linhares, additional, Couto, Ricardo Neves, additional, Guedes, Rinária de Quadro Figueiredo, additional, Vieira, Rita de Cássia de Sousa, additional, Alves, Rita de Cássia Loiola, additional, Pinto, Rita de Cássia Sampaio Bessa, additional, Silva, Rita Wigna de Souza, additional, Rocha, Rivalda Oliveira, additional, Oliveira, Roberta de Paula, additional, Moreira, Roberta Magda Martins, additional, Nunes, Roberta, additional, Carvalho, Roberta Wanda Fernandes Chaves, additional, Sá, Rodrigo Avelar Reis, additional, Rocha, Rodrigo Brito da, additional, Mendonça, Rodrigo Fontenele, additional, Nascimento, Rodrigo Vieira do, additional, Lima Filho, Romério de Oliveira, additional, Lima, Rômulo de Morais, additional, Araújo, Roniuza Reneuda de, additional, Ramos, Rosana Conceição Leal, additional, Ramos, Rosana Conceição Rodrigues Leal, additional, Silva, Rosana Pereira Lima da, additional, Santana, Rosane da Silva, additional, Batista, Rose Danielle de Carvalho, additional, Veras, Ruan Pablo Marques, additional, Bezerra, Rubens Pinheiro, additional, Silveira, Rui Paixão Ribeiro, additional, Rodrigues, Rute Sousa, additional, Carvalho, Ruth Gorete dos Santos, additional, Farias, Ruth Raquel Soares de, additional, França, Sabrina da Silva, additional, Sousa, Sabrina de Araujo de, additional, Costa, Sabrina Maria Aguiar, additional, Barros, Sabrina Pereira, additional, Silva, Sabrina Soares da, additional, Fortes, Sabrina Tajra, additional, Santos, Samara de Sena, additional, Martins, Samara Eduarda, additional, Oliveira, Samara Marques de, additional, Silva, Sâmara Mércia Reis, additional, Silva, Sâmia Luiza Coêlho da, additional, Torres, Samir da Rocha Fernandes, additional, Leal, Samira Rego Martins de Deus, additional, Sousa, Samuel Barbosa, additional, Almeida, Samuel Lucas de, additional, Silva, Sandra Maria Oliveira da, additional, Santos, Sandra Vírgínia Costa, additional, Sales, Sandy Pereira de, additional, Chaves, Sandy Teles Azevedo, additional, Monteiro, Sara Dalene da Silva, additional, Barbosa, Sara Machado Miranda Leal, additional, Melo, Sara Naielly Alves, additional, Medeiros, Sara Sabrina Lima, additional, Soares, Sara Silva, additional, Lima, Sarah Beatriz Rocha, additional, Sousa, Sarah Cristina Ericeira, additional, Sousa, Sarah Emanuele Pinho de, additional, Carvalho, Sarah Maria Osório de, additional, Rocha, Sarah Ravena Camilo Sobreira, additional, Cardoso, Saraí de Brito, additional, Nascimento, Scarleth Alencar do, additional, Monte, Semíramis Jamil Hadad do, additional, Aragão, Sergio Rodrigo Câmara Paiva, additional, Sousa, Shamylle Ribeiro, additional, Nunes, Sheila Elke Araújo, additional, Medeiros, Sheila Raíza Araujo, additional, Silva, Sheyla Santos, additional, Oliveira, Silmara Ferreira de, additional, Costa, Silvestre de Sousa da, additional, Brandão, Socorro Adriana de Sousa Meneses, additional, Albuquerque, Sofia dos Santos, additional, Barbosa, Soraya Nunes, additional, Moreno, Stefane Marinho, additional, Sousa, Stefhani Medeiros de, additional, Oliveira, Stephanie Karoline de Oliveira, additional, Pereira, Stephanny Ingrid Nunes, additional, Araújo, Stephannye Campelo de, additional, Lages, Suellen Alves, additional, Santos, Sueyla Ferreira da Silva dos, additional, Fenelon, Susy Canuto de Oliveira, additional, Lima, Suyanne Soares, additional, Alencar, Suzy Romere Silva de, additional, Silva, Tainá Maria Oliveira, additional, Vitorino, Talita Gomes, additional, Anjos, Talles Davi de Valença Moura Soares dos, additional, Almeida, Talysse Henna da Rocha Graciano de, additional, Gonçalves, Tamar Lima, additional, Ferreira, Tâmila Yasmim Lima, additional, Lima, Tamirys Cavalcante, additional, Bezerra, Tárcilla Pinto Passos, additional, Sousa, Tássia Farias de, additional, Guimarães, Tatiana Maria Melo, additional, Daboit, Tatiane Caroline, additional, Rodrigues, Tatyanne Silva, additional, Silva, Taynara Laís, additional, Silva, Taynara Leticia Braga, additional, Nascimento, Tayrine Helen Marques do, additional, Santos, Tays de Oliveira, additional, Santos, Taysman Medeiros Barbosa, additional, Lima, Telma Vieira, additional, Garcês, Tereza Cristina de Carvalho Souza, additional, Neves, Tereza Maria Alcântara, additional, Lima, Thaiane Damasceno de, additional, Lima, Thainnar de Moura, additional, Moraes, Thaís Anielle Ferreira, additional, Sousa, Thaís Emmanuele Passos, additional, Narciso, Thais Kessia Rodrigues, additional, Oliveira, Thais Luz, additional, Gomes, Thais Rayane da Conceição, additional, Souza, Thalis Ferreira de, additional, Araújo, Thalis Kennedy Azevedo de, additional, Antunes, Thallyta Maria Tavares, additional, Fonsêca, Thalya Emilia Bessa, additional, Carneiro, Thalyta Lorrane Lopes, additional, Carvalho, Thamara Evelline de Sousa, additional, Vieira, Thamyris Cardoso, additional, Cutrim, Thanmyris da Silva, additional, and Maranhão, Thatiana Araújo, additional

Published
2023
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18. Laryngeal and Esophageal Mucosal Protection Using the Angico Gum Biopolymer in a Mouse Model of Reflux

Author

Sales, Thiago Meneses Araújo Leite, primary, do Nascimento, Renata Rocha, additional, do Carmo Neto, João Pedro, additional, da Costa Filho, Humberto Barbosa, additional, Paula, Suliana Mesquita, additional, Sousa, Maria Klayre Araújo de, additional, de Melo Nogueira, Kerolayne, additional, Junior, Genílson José Dias, additional, da Silva, Durcilene Alves, additional, Soares, Pedro Marcos Gomes, additional, Medeiros, Jand Venes Rolim, additional, Nicolau, Lucas Antonio Duarte, additional, Sifrim, Daniel, additional, and de Souza, Marcellus Henrique Loiola Ponte, additional

Published
2022
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19. Laryngeal and Esophageal Mucosal Protection Using the Angico Gum Biopolymer in a Mouse Model of Reflux.

Author

Sales, Thiago Meneses Araújo Leite, do Nascimento, Renata Rocha, do Carmo Neto, João Pedro, da Costa Filho, Humberto Barbosa, Paula, Suliana Mesquita, Sousa, Maria Klayre Araújo de, de Melo Nogueira, Kerolayne, Junior, Genílson José Dias, da Silva, Durcilene Alves, Soares, Pedro Marcos Gomes, Medeiros, Jand Venes Rolim, Nicolau, Lucas Antonio Duarte, Sifrim, Daniel, and de Souza, Marcellus Henrique Loiola Ponte

Abstract

Objective: This study aimed to evaluate the in vivo protective effect of the angico gum biopolymer in reducing the inflammatory response and preserving the integrity of the laryngeal and esophageal mucosa. Study Design: Animal study. Methods: A murine surgical model of gastroesophageal reflux disease was accomplished and subsequently treated with angico gum or omeprazole. On days 3 and 7 post surgery, samples of the larynx and esophagus, respectively, were collected to measure the level of inflammation (wet weight and myeloperoxidase activity) and mucosal integrity (transepithelial electrical resistance and mucosal permeability to fluorescein). Results: Angico gum and omeprazole decreased laryngeal inflammation (wet weight and myeloperoxidase activity) and dramatically improved the integrity of the laryngeal mucosa. It also reduced inflammation (decreased wet weight and myeloperoxidase activity) of the esophagus and preserved the barrier function (inferred by assessing the integrity of the mucosa). Conclusion: This study demonstrates the protective effect of angico gum in an experimental gastroesophageal reflux disease model. Angico gum attenuates inflammation and impairment of the mucosal barrier function not only in the larynx but also in the esophagus. Level of Evidence: NA Laryngoscope, 133:162–168, 2023 [ABSTRACT FROM AUTHOR]

Published
2023
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21. Cannabidiol: brief compilation over a versatile molecule

Author

Paula, Caico Bruno Curcio Oliva de, primary, Baldacci, Enzo Andrade, additional, Cheng, Lucas Chen, additional, Gozzi, Mateus Bulbow, additional, Shibuya, Pedro Torquato, additional, Nicolau, Lucas Antonio Duarte, additional, Medeiros, Jand Venes Rolim, additional, Anghinah, Renato, additional, Oliveira, Juliane Vismari de, additional, Gehrke, Flávia de Sousa, additional, and Menezes-Rodrigues, Francisco Sandro, additional

Published
2021
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23. Anti-Inflammatory, Antinociceptive, and Antioxidant Properties of Anacardic Acid in Experimental Models

Author

Gomes Júnior, Antonio Luiz, primary, Islam, Muhammad Torequl, additional, Nicolau, Lucas Antonio Duarte, additional, de Souza, Luan Kevin Miranda, additional, Araújo, Tiago de Souza Lopes, additional, Lopes de Oliveira, Guilherme Antônio, additional, de Melo Nogueira, Kerolayne, additional, da Silva Lopes, Luciano, additional, Medeiros, Jand-Venes Rolim, additional, Mubarak, Mohammad S., additional, and Melo-Cavalcante, Ana Amélia de Carvalho, additional

Published
2020
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24. Esophagoprotective effect of a biopolymer, cashew gum, in murine non-erosive reflux disease and in human esophageal mucosa: antiinflammatory profile and topical effect

Author

Nicolau, Lucas Antonio Duarte and Souza, Marcellus Henrique Loiola Ponte de

Subjects
Inflamação, Anacardium occidentale, Refluxo Gastroesofágico, Neopreno
Abstract

Gastroesophageal reflux disease (GERD) can be defined as symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus. Alternative ways of treatment must be considered since the standard therapy fails in all phenotypes of GERD, expressly in the most prevalent form (Non-Erosive Reflux Disease, NERD). We aimed to assess the esophageal mucosal protection effect of the biopolymer cashew gum (CG), a natural product obtained from bark of Brazilian northeastern tree (Anacardium occidentale L.), in mice (experimental model of NERD, non-erosive reflux disease) and in human esophageal biopsies. Experimental design was divided in “Pré-Clinical Studies: Murine NERD” and in “Human Oesophageal Biopsies Studies”. Firstly, mice were achieved by a surgical induction of NERD in which a pyloric sub-stenosis and ligation of forestomach were performed. After 7 days, animals were euthanized and samples of distal oesophagus taken to assess suggestive hallmarks of inflammation such as oedema, MPO activity and neutrophil infiltrate [histologic scores and keratinocyte-derived cytokine (KC)]. In functional studies, distal oesophageal samples of mice were mounted in Üssing chambers to evaluate Transepithelial Electrical Resistance (TER) and permeability to fluorescein. In human esophageal biopsies, it was evaluated TER and permeabiliy, but with pH adjustment to 2. As control in biopsies studies, alginate was used, besides sucralfate also was evaluated. In addition, an acute toxicity test was conducted in accordance with OECD guideline 423. Finally, we performed an epifluorescence microscopy to localize on the oesopageal epithelium the biopolymer previously labeled with FITC. In our study, animals with NERD established oesophageal oedema (augmented wet weight as an indirect oedema hallmark and altered histologic architecture as a direct oedema hallmark) and increased MPO activity (15.90±1.68 mg/cm and 23.14±9.3 U/mg tissue, respectively), while CG daily administration reduced (P

Published
2018

25. Cardiovascular Effect of Diosgenin in Ovariectomized Rats

Author

Morais, Ilmara Cecilia Pinheiro de Silva, primary, Moura, Iris Jordânia Luz, additional, Sabino, Carla Kelly Barroso, additional, Nicolau, Lucas Antonio Duarte, additional, Souza, Fabiana de Moura, additional, Silva-Filho, José Couras da, additional, Oliveira, Rita de Cássia Meneses, additional, Medeiros, Jand Venes Rolim, additional, Lima, Sidney Gonçalo de, additional, and Oliveira, Aldeidia Pereira de, additional

Published
2019
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26. Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus microphyllus leaves, protects against naproxen-induced gastrointestinal damage in rats

Author

Nicolau, Lucas Antonio Duarte, Carvalho, Nathalia S., Pacífico, Dvison M., Lucetti, Larisse T., Aragão, Karoline Sabóia, Véras, Leiz M.C., Souza, Marcellus H.L.P., Leite, José R.S.A., and Medeiros, Jand Venes R.

Subjects
Naproxen, Jaborandi, Naproxeno
Abstract

Objective This study aimed to investigate the protective effect of epiisopiloturine hydrochloride (EPI), an imidazole alkaloid, on NAP-induced gastrointestinal damage in rats. Methods Initially, rats were pretreated with 0.5% carboxymethylcellulose (vehicle) or EPI (3, 10 and 30 mg/kg, p.o. or i.p., groups 3–5, respectively) twice daily, for 2 days. After 1 h, NAP (80 mg/kg, p.o.) was given. The control group received only vehicle (group 1) or vehicle + naproxen (group 2). Rats were euthanized on 2nd day, 4 h after NAP treatment. Stomachs lesions were measured. Samples were collected for histological evaluation and glutathione (GSH), malonyldialdehyde (MDA), myeloperoxidase (MPO), and cytokines levels. Moreover, gastric mucosal blood flow (GMBF) was evaluated. Results EPI pretreatment prevented NAP-induced macro and microscopic gastric damage with a maximal effect at 10 mg/kg. Histological analysis revealed that EPI decreased scores of damage caused by NAP. EPI reduced MPO (3.4 ± 0.3 U/mg of gastric tissue) and inhibited changes in MDA (70.4 ± 8.3 mg/g of gastric tissue) and GSH (246.2 ± 26.4 mg/g of gastric tissue). NAP increased TNF-α levels, and this effect was reduced by EPI pretreatment. Furthermore, EPI increased GMBF by 15% compared with the control group. Conclusion Our data show that EPI protects against NAP-induced gastric and intestinal damage by reducing pro-inflammatory cytokines, reducing oxidative stress, and increasing GMBF.

Published
2017

27. The anti-inflammatory effects of N-methyl-(2S,4R)- trans -4-hydroxy- l -proline from Syderoxylon obtusifolium are related to its inhibition of TNF-alpha and inflammatory enzymes

Author

Aquino, Pedro Everson Alexandre de, Magalhães, Talita Rocha, Nicolau, Lucas Antonio Duarte, Leal, Luzia Kalyne Almeida Moreira, Aquino, Nayara Coriolano de, Santos, Sabrina Matias dos, Neves, Kelly Rose Tavares, Silveira, Edilberto Rocha, and Viana, Glauce Socorro de Barros

Subjects
Sapotaceae, Estresse Oxidativo, Citocinas
Abstract

Background Sideroxylon obtusifolium (Roem. & Schult.) T.D. Penn., Sapotaceae family, is a medicinal species native to the Brazilian Northeastern region. The plant is popularly used as an anti-inflammatory and hypoglycemic. Purpose To evaluate the anti-inflammatory properties of the N-methyl-(2S,4R)-trans-4-hydroxy-l-proline (NMP) from S. obtusifolium leaves in models of inflammation and to clarify its action mechanisms. Methods Male Swiss mice were distributed intocontrols and groups treated with NMP (25, 50 and 100 mg/kg, p.o.), indomethacin or morphine (reference drugs). The animals were subjected to the formalin, carrageenan-induced edema and peritonitis tests. Furthermore, peritoneal lavage and slices from edematous paws were used for histological and immunohistochemical (iNOS, TNF-alpha, COX-2 and NF-kB) assays. Results Decreases in licking time, in the 1st and mainly in the 2nd phases of the formalin test, were shown after NMP treatments. In addition, decreases (around 50%) in paw edema were noticed at the 3rd h. The HE staining of paw slices demonstrated a complete reversion of the increased PMN cell numberafter NMP treatment. Similarly, decreases higher than 70% were also demonstrated in PMN cells, in the peritoneal fluid. Furthermore, NMP significantly decreased iNOS, TNF-alpha, COX-2 and NF-kB immunoreactivities. Conclusions We showed that S. obtusifolium presents a potent anti-inflammatory activity, due to the presence of the N-methyl-(2S,4R)-trans-4-hydroxy-l-proline(NMP) in the plant extract. This action is related to the inhibition by NMP of TNF-alpha and inflammatory enzymes.

Published
2017

28. The hydrogen sulfide donor, Lawesson’s reagent, prevents alendronate-induced gastric damage in rats

Author

Nicolau, Lucas Antonio Duarte, Silva, R.O., Damasceno, Samara Rodrigues Bonfim, Carvalho, N.S., Costa, N.R.D., Aragão, Karoline Sabóia, Barbosa, A.L.R., Soares, P.M.G., Souza, M.H.L.P., and Medeiros, J.V.R.

Subjects
Alendronato, Sulfeto de Hidrogênio
Abstract

Our objective was to investigate the protective effect of Lawesson’s reagent, an H2S donor, against alendronate (ALD)-induced gastric damage in rats. Rats were pretreated with saline or Lawesson’s reagent (3, 9, or 27 mmol/kg, po) once daily for 4 days. After 30 min, gastric damage was induced by ALD (30 mg/kg) administration by gavage. On the last day of treatment, the animals were killed 4 h after ALD administration. Gastric lesions were measured using a computer planimetry program, and gastric corpus pieces were assayed for malondialdehyde (MDA), glutathione (GSH), proinflammatory cytokines [tumor necrosis factor (TNF)-a and interleukin (IL)-1b], and myeloperoxidase (MPO). Other groups were pretreated with glibenclamide (5 mg/kg, ip) or with glibenclamide (5 mg/kg, ip)+diazoxide (3 mg/kg, ip). After 1 h, 27 mmol/kg Lawesson’s reagent was administered. After 30 min, 30 mg/kg ALD was administered. ALD caused gastric damage (63.35±9.8 mm2); increased levels of TNF-a, IL-1b, and MDA (2311±302.3 pg/mL, 901.9±106.2 pg/mL, 121.1±4.3 nmol/g, respectively); increased MPO activity (26.1±3.8 U/mg); and reduced GSH levels (180.3±21.9 mg/g). ALD also increased cystathionine-c-lyase immunoreactivity in the gastric mucosa. Pretreatment with Lawesson’s reagent (27 mmol/kg) attenuated ALD-mediated gastric damage (15.77±5.3 mm2); reduced TNFa, IL-1b, and MDA formation (1502±150.2 pg/mL, 632.3±43.4 pg/mL, 78.4±7.6 nmol/g, respectively); lowered MPO activity (11.7±2.8 U/mg); and increased the level of GSH in the gastric tissue (397.9±40.2 mg/g). Glibenclamide alone reversed the gastric protective effect of Lawesson’s reagent. However, glibenclamide plus diazoxide did not alter the effects of Lawesson’s reagent. Our results suggest that Lawesson’s reagent plays a protective role against ALD-induced gastric damage through mechanisms that depend at least in part on activation of ATP-sensitive potassium (KATP) channels.

Published
2013

29. Antiinflammatory and antinociceptive effects in mice of a sulfated polysaccharide fraction extracted from the marine red algaeGracilaria caudata

Author

Chaves, Luciano de Sousa, primary, Nicolau, Lucas Antonio Duarte, additional, Silva, Renan Oliveira, additional, Barros, Francisco Clark Nogueira, additional, Freitas, Ana Lúcia Ponte, additional, Aragão, Karoline Sabóia, additional, Ribeiro, Ronaldo de Albuquerque, additional, Souza, Marcellus Henrique Loiola Ponte, additional, Barbosa, André Luiz dos Reis, additional, and Medeiros, Jand-Venes Rolim, additional

Published
2012
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30. Sulfated-Polysaccharide Fraction from Red Algae Gracilaria caudata Protects Mice Gut Against Ethanol-Induced Damage

Author

Silva, Renan Oliveira, primary, Santos, Geice Maria Pereira dos, additional, Nicolau, Lucas Antonio Duarte, additional, Lucetti, Larisse Tavares, additional, Santana, Ana Paula Macedo, additional, Chaves, Luciano de Souza, additional, Barros, Francisco Clark Nogueira, additional, Freitas, Ana Lúcia Ponte, additional, Souza, Marcellus Henrique Loiola Ponte, additional, and Medeiros, Jand-Venes Rolim, additional

Published
2011
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31. Antiinflammatory and antinociceptive effects in mice of a sulfated polysaccharide fraction extracted from the marine red algae Gracilaria caudata.

Author

Chaves, Luciano de Sousa, Nicolau, Lucas Antonio Duarte, Silva, Renan Oliveira, Barros, Francisco Clark Nogueira, Freitas, Ana Lúcia Ponte, Aragão, Karoline Sabóia, Ribeiro, Ronaldo de Albuquerque, Souza, Marcellus Henrique Loiola Ponte, Barbosa, André Luiz dos Reis, and Medeiros, Jand-Venes Rolim

Subjects
*ANTI-inflammatory agents, *ANALGESICS, *LABORATORY mice, *POLYSACCHARIDES, *GRACILARIA, *RED algae, *EDEMA, *MYELOPEROXIDASE, *THERAPEUTICS
Abstract

Many algal species contain relatively high concentrations of polysaccharide substances, a number of which have been shown to have anti-inflammatory and/or immunomodulatory activity. In this study, we evaluated the anti-inflammatory and antinociceptive effects in mice of a sulfated polysaccharide fraction (PLS) extracted from the algae Gracilaria caudata. The antiinflammatory activity of PLS was evaluated using several inflammatory agents (carrageenan, dextran, bradykinin, and histamine) to induce paw edema and peritonitis in Swiss mice. Samples of the paw tissue and peritoneal fluid were removed to determine myeloperoxidase (MPO) activity or TNF-α and IL-1β levels, respectively. Mechanical hypernociception was induced by subcutaneous injection of carrageenan into the plantar surface of the paw. Pretreatment of mice by intraperitoneal administration of PLS (2.5, 5, and 10 mg/kg) significantly and dose-dependently reduced carrageenan-induced paw edema ( p < 0.05) compared to vehicle-treated mice. Similarly, PLS 10 mg/kg effectively inhibited edema induced by dextran and histamine; however, edema induced by bradykinin was unaffected by PLS. PLS 10 mg/kg inhibited total and differential peritoneal leukocyte counts following carrageenan-induced peritonitis. Furthermore, PLS reduced carrageenan-increased MPO activity in paws and reduced cytokine levels in the peritoneal cavity. Finally PLS pretreatment also reduced hypernociception 3-4 h after carrageenan. We conclude that PLS reduces the inflammatory response and hypernociception in mice by reducing neutrophil migration and cytokines concentration. [ABSTRACT FROM AUTHOR]

Published
2013
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32. Long-term administration of Omeprazole promotes behavioral, inflammatory and oxidative changes in the Central Nervous System of mice

Author

Coelho, Dulce Maria Nascimento, Sousa, Francisca Cléa Florenço de, and Nicolau, Lucas Antonio Duarte

Subjects
Sistema Nervoso Central, Inibidores da Bomba de Prótons, Omeprazol
Abstract

Omeprazole, the first proton pump inhibitors developed, is still widely used in clinical practice and has its widespread use in the population. Despite its great efficacy and considerable safety profile, recently clinical studies have been linking its chronic use to central effects. Currently, the increase in the occurrence of neuropsychiatric disorders is a global concern, and it is essential to identify preventable factors, such as adverse effects to the use of medications. This study aimed at identifying the chronic administration effects of Omeprazole in the CNS of adult mice in a dose equivalent to that used in the clinic, investigating alterations in behavioral, inflammatory and oxidative parameters. For this, C57BL/6 adult male mice, weighing between 20-30g, were used and divided into two groups: OME and Sham, each received either solutions of Omeprazole (8 mg/kg) or vehicle (sodium bicarbonate pH 8.4) respectively, orally by gavage for 28 days. 24 hours after the last administration, the animals were submitted to the following behavioral tests: Open Field (OF) and Rotarod, Forced Swimming Test (FST), elevated plus maze, Y maze (YM), passive avoidance, object recognition (OR) and pre-pulse inhibition. The weight of the animals was registered in 48-72h intervals during the protocol. Moreover, the following brain areas - hippocampus (HP), prefrontal cortex (PFC) and striatum - were dissected, weighted, and the serum was collected. Oxidative stress parameters, malondialdehyde (MDA), nitrite/nitrate and reduced glutathione (GSH), were quantified in brain areas. The inflammatory markers, IL-1β and TNF-α, were measured in peripheral blood and in HP and PFC. The project was approved by the Ethics Committee on the Use of Animals of the Federal University of Ceará filed under no. 1977300718. The following results were observed: a decrease in the crossing parameter in the OF, no change in the motor performance verified by the Rotarod test, a reduction in the immobility time in the FST, an improvement in the percentage of correct alternances in the YM and a reduced in the exploration time in the novel object in the OR. Furthermore, a reduced weight gain and hippocampal weight were observed in Omeprazole-treated mice. Regarding the inflammatory and oxidative stress parameters, there was an increase in the cytokine IL1-β levels in the PFC and serum, whereas TNF-α only in the PFC. Nitrate/nitrite levels increased in HP and PFC, while MDA and GSH levels decreased. These findings suggest that Omeprazole improves depressive-like behavior and working memory, likely through the increase in Nitrate/Nitrite and reduction in MDA levels in PFC and HP. Whereas, the finding regarding the impairment of the recognition memory is more likely to be related to the reduced hippocampal weight. The diminished weight gain might be associated with the IL-1β increased levels in the peripheral blood. Lastly, the results of the present study alongside with the evidence already published, reinforces the cautions and attention concerning the long-term use of Omeprazole should be considered as well as the necessity of doing more studies to better understand the underlying mechanisms behind these effects. O Omeprazol, primeiro representante da classe dos inibidores da bomba de prótons, é ainda o mais utilizado na prática clínica e tem seu uso bastante difundido na população. Apesar de sua ótima eficácia e considerável perfil de segurança, estudos de natureza clínica têm relacionado seu uso crônico a efeitos centrais. O aumento da ocorrência de transtornos neuropsiquiátricos é uma preocupação global, sendo fundamental a identificação de fatores evitáveis, como efeitos adversos ao uso de medicamentos. O objetivo deste trabalho foi, então, compreender os efeitos da administração crônica de Omeprazol no sistema nervoso central de camundongos em dose equivalente à utilizada na clínica, investigando alterações comportamentais, inflamatórias e oxidativas. Para isto, camundongos C57BL/6 adultos machos, com peso entre 20-30 g foram utilizados e divididos em dois grupos: OME e Sham, os quais receberam as soluções de Omeprazol (8 mg/kg) e do veículo (bicarbonato de sódio pH 8.4), respectivamente, por gavagem, via oral, durante 28 dias. 24h após a última administração, os animais foram submetidos aos testes comportamentais: Campo Aberto (CA), Rotarod, Nado Forçado (NF), Labirinto em Cruz Elevado, Inibição Pré-Pulso, Esquiva Passiva, Labirinto em Y (LY) e Reconhecimento de Objetos (RO). Ademais, foi registrado o peso dos animais com intervalos de 48-72h durante o protocolo. Após a eutanásia, as áreas do hipocampo (HP), córtex pré-frontal (CPF) e corpo estriado (CE) foram dissecadas, pesadas, e o soro, coletado. Os parâmetros do estresse oxidativo, malondialdeído (MDA), nitrato/nitrito e glutationa reduzida (GSH) foram dosados nas áreas cerebrais. Os marcadores inflamatórios, IL-1β e TNF-α, foram dosados no soro, HP e CPF. O estudo foi aprovado no Comitê de Ética no Uso de Animais da Universidade Federal do Ceará, protocolado sob o nº 1977300718. Os resultados mostram diminuição do parâmetro de crossing no CA, sem nenhuma alteração no desempenho motor no Rotarod, redução do tempo de imobilidade no NF, aumento no número de alternâncias corretas no LY e redução do tempo de exploração ao objeto novo no RO. Houve redução do peso do HP e do ganho de peso corporal no grupo OME. A avaliação neuroquímica revelou aumento dos níveis de IL-1β no CPF e no soro, e de TNF-α apenas no CPF. Os níveis de nitrato/nitrito aumentaram no HP e CPF, enquanto os de MDA e GSH diminuíram em todas as áreas cerebrais. Diante dos resultados, sugere-se que Omeprazol melhorou o comportamento tipo depressivo e a memória de trabalho por meio do aumento dos níveis de nitrato/nitrito e redução de MDA no CPF e HP. Em relação ao prejuízo na memória de reconhecimento pode estar associado à diminuição do peso do hipocampo. A redução do ganho de peso corporal pode estar relacionada ao aumento dos níveis de IL-1β no sangue periférico. A partir dos resultados encontrados junto às evidências já publicadas, reforça-se a importância de maior cautela no uso crônico de Omeprazol e a necessidade de realizar mais estudos visando à melhor compreensão dos mecanismos por trás dos efeitos desse fármaco.

Published
2021

33. Biopolimero da goma do angico, obtido da casca da Anadenanthera colubrina, protege a mucosa laríngea e esofágica em modelo de refluxo gastresofágico em camundongos

Author

Carmo Neto, João Pedro, Souza, Marcellus Henrique Loiola Ponte de, and Nicolau, Lucas Antonio Duarte

Subjects
Mucosa Laríngea, Mucosa Esofágica, Fluoresceína, Refluxo Gastroesofágico
Abstract

A doenca do refluxo gastroesofagico (DRGE) tem uma alta prevalencia mundial e impacto na qualidade de vida, assim podendo ter complicacoes esofagicas e extraexofagicas. Alem disso, a terapia padrao com IBPs e o tratamento de escolha, cerca de um terco dos pacientes nao responde adequadamente ao tratamento, principalmente aqueles com doenca nao erosiva. O presente estudo teve por objetivo avaliar o efeito protetor na mucosa laringea e esofagica, do biopolimero da Goma do Angico (GA), obtido da casca da Anadenanthera colubrina, em um modelo de refluxo gastroesofagico em camundongos. Inicialmente, os camundongos foram submetidos a uma inducao cirurgica do refluxo gastroesofagico, na qual realizou-se uma sub-estenose pilorica seguida de ligadura de fundo gastrico. Durante 3 dias (laringe) e 7 dias (esofago), os animais foram tratados com salina ou GA diariamente em diversas concentracoes. Entao nos respectivos dias, os animais foram eutanasiados e amostras de laringe e esofago distal foram retiradas para avaliar parametros inflamatorios, edema e atividade da MPO. No estudo da funcao de barreira, amostras de laringe e esofago distal foram montadas em camaras Ussing para avaliar a Resistencia Eletrica Transepitelial (RETE) e, em seguida, a permeabilidade a fluoresceina. No presente estudo, os animais com refluxo gastroesofagico sem tratamento apresentaram um edema laringeo e esofagico (peso umido aumentado) e aumento da atividade de MPO, enquanto a administracao diaria de GA 10 % reduziu (P

Published
2020

34. Use of etomidate in endotracheal intubations in the emergency room during the COVID-19 pandemic: a randomized clinical trial.

Author

Tallo FS, Pires-Oliveira M, Nakai MY, Nicolau LAD, Medeiros JVR, Gehrke FS, Taha MO, Caricati-Neto A, Menezes-Rodrigues FS, and Abib SCV

Subjects
Humans, Male, Female, Middle Aged, Aged, Adult, Pandemics, SARS-CoV-2, Brazil epidemiology, Anesthetics, Intravenous administration & dosage, Etomidate, Intubation, Intratracheal methods, Emergency Service, Hospital statistics & numerical data, COVID-19, Hypnotics and Sedatives administration & dosage, Hypnotics and Sedatives therapeutic use, Hospital Mortality
Abstract

Purpose: Shock, cardiovascular problems, and respiratory failure constitute the main causes of death in patients cared in medical emergency rooms. Patients commonly require orotracheal intubation (OTI), a fact that has been intensified by diseases that generate important and fatal hemodynamic and respiratory problems in the affected patient., Methods: Although etomidate (ETO) is a highly used anesthetic for OTI, its use remains controversial in several scenarios. Some studies refer to an increase in mortality with its use in critically patients, while others do not refer to a difference. Therefore, we evaluated the mortality of patients submitted to OTI in the public hospital of a public federal university, with the use of ETO and other sedative-hypnotic drugs used in the induction of the performance of OTI, with the in-hospital mortality of patients cared in hospital., Results: The results demonstrate that the use of ETO as a hypnotic for OTI in the emergency room is not associated with a significant difference in morbidity or early mortality, within 30 days of hospitalization, compared with other hypnotics., Conclusions: There was no difference in mortality between patients intubated in the emergency department who used ETO and those who used non-ETO hypnotic within 72 hours and 30 days.

Published
2024
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