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Metabolic imaging of the human brain by in-vivo magnetic resonance spectroscopic imaging (MRSI) can non-invasively probe neurochemistry in healthy and disease conditions. MRSI at ultra-high field (≥ 7 T) provides increased sensitivity for fast high-resolution metabolic imaging, but comes with technical challenges due to non-uniform B0 field. Here, we show that an integrated RF-receive/B0-shim (AC/DC) array coil can be used to mitigate 7 T B0 inhomogeneity, which improves spectral quality and metabolite quantification over a whole-brain slab. Our results from simulations, phantoms, healthy and brain tumor human subjects indicate improvements of global B0 homogeneity by 55%, narrower spectral linewidth by 29%, higher signal-to-noise ratio by 31%, more precise metabolite quantification by 22%, and an increase by 21% of the brain volume that can be reliably analyzed. AC/DC shimming provide the highest correlation (R2 = 0.98, P = 0.001) with ground-truth values for metabolite concentration. Clinical translation of AC/DC and MRSI is demonstrated in a patient with mutant-IDH1 glioma where it enables imaging of D-2-hydroxyglutarate oncometabolite with a 2.8-fold increase in contrast-to-noise ratio at higher resolution and more brain coverage compared to previous 7 T studies. Hence, AC/DC technology may help ultra-high field MRSI become more feasible to take advantage of higher signal/contrast-to-noise in clinical applications.

MR spectroscopic imaging (MRSI) noninvasively maps the metabolism of human brains. In particular, the imaging of D-2-hydroxyglutarate (2HG) produced by glioma isocitrate dehydrogenase (IDH) mutations has become a key application in neuro-oncology. However, the performance of full field-of-view MRSI is limited by B0 spatial nonuniformity and lipid artifacts from tissues surrounding the brain. Array coils that multiplex RF-receive and B0 -shim electrical currents (AC/DC mixing) over the same conductive loops provide many degrees of freedom to improve B0 uniformity and reduce lipid artifacts. AC/DC coils are highly efficient due to compact design, requiring low shim currents (

MR spectroscopic imaging (MRSI) noninvasively maps the metabolism of human brains. In particular, the imaging of D-2-hydroxyglutarate (2HG) produced by glioma isocitrate dehydrogenase (IDH) mutations has become a key application in neuro-oncology. However, the performance of full field-of-view MRSI is limited by B(0) spatial nonuniformity and lipid artifacts from tissues surrounding the brain. Array coils that multiplex RF-receive and B(0)-shim electrical currents (AC/DC mixing) over the same conductive loops provide many degrees of freedom to improve B(0) uniformity and reduce lipid artifacts. AC/DC coils are highly efficient due to compact design, requiring low shim currents (

Purpose: B1+ and T1 corrections and dynamic multi-coil shimming approaches were proposed to improve the fidelity of high isotropic resolution Generalized slice dithered enhanced resolution (gSlider) diffusion imaging. Methods: An extended reconstruction incorporating B1+ inhomogeneity and T1 recovery information was developed to mitigate slab-boundary artifacts in short-TR gSlider acquisitions. Slab-by-slab dynamic B0 shimming using a multi-coil integrated {\Delta}B0/Rx shim-array, and high in-plane acceleration (Rinplane=4) achieved with virtual-coil GRAPPA were also incorporated into a 1 mm isotropic resolution gSlider acquisition/reconstruction framework to achieve an 8-11 fold reduction in geometric distortion compared to single-shot EPI. Results: The slab-boundary artifacts were alleviated by the proposed B1+ and T1 corrections compared to the standard gSlider reconstruction pipeline for short-TR acquisitions. Dynamic shimming provided >50% reduction in geometric distortion compared to conventional global 2nd order shimming. 1 mm isotropic resolution diffusion data show that the typically problematic temporal and frontal lobes of the brain can be imaged with high geometric fidelity using dynamic shimming. Conclusions: The proposed B1+ and T1 corrections and local-field control substantially improved the fidelity of high isotropic resolution diffusion imaging, with reduced slab-boundary artifacts and geometric distortion compared to conventional gSlider acquisition and reconstruction. This enabled high-fidelity whole-brain 1 mm isotropic diffusion imaging with 64 diffusion-directions in 20 minutes using a 3T clinical scanner.

PURPOSE: We designed and implemented an orthogonal shim array consisting of shim coils with their planes perpendicular to the planes of neighboring radio-frequency (RF) coils. This shim coil improves the magnetic field homogeneity with the minimal interference to RF coils. METHODS: Using realistic off resonance maps of the human brain, we first evaluated the performance of shim coils in different orientations. Based on simulations, we developed a 7-channel orthogonal shim array, whose coil plan was perpendicular to neighboring RF coils, at the forehead. A programmable open-source current driver supplied shim currents. RESULTS: The 7-channel orthogonal shim array caused only marginal SNR loss to the integrated 32-channel RF-shim array. The 7-channel orthogonal shim array itself improved the magnetic field homogeneity by 30% in slice-optimized shimming, comparable to the baseline shimming offered by the scanner’s second order spherical harmonic shimming. CONCLUSION: Orthogonal shim coils can improve the field homogeneity while maintaining good image SNR.

s Functional magnetic resonance imaging (fMRI) in monkeys is important for bridging the gap between invasive animal brain studies and non-invasive human brain studies. To resolve the finer functional structure of the monkey brain, ultra-high-field (UHF) MR is essential, and high-performance, close-fitting RF receive coils are typically desired to fully leverage the intrinsic gains provided by UHF MRI. Moreover, static field (B0) inhomogeneity arising from the tissue susceptibility interface is more severe at UHF, presenting an obstacle to achieving high-resolution fMRI. B0 shim of the monkey head is challenging due to its smaller size and more complex sources of B0 offsets in multi-modal imaging tasks. In the present work, we have customized an array coil for lightly-anesthetized monkey fMRI in the 7T human scanner that combines RF and multi-coil (MC) B0 shim functionality (also referred to as AC/DC coils) to provide high imaging SNR and high-spatial-order, rapidly switchable B0-shim capability. Additional space was retained on the coil to render it compatible with monkey multi-modal imaging studies. Both MC global (whole-volume) and dynamic (slice-optimized) shim methods were tested and evaluated, and the benefits of MC shim for fMRI experiments was also studied. A minor reduction in RF coil performance was found after introducing additional B0 shim circuitry. However, the proposed RF coil provided higher image SNR and more uniform contrast compared to a commercially available coil for human knee imaging. Compared with static 2nd-order shim, the B0 inhomogeneity was reduced by 56.8%, and 95-percentile B0 offset was reduced to within 28.2 Hz through MC shim, versus 68.7 Hz with 2nd-order static shim. As a result, functional image quality could be improved, and brain activation can be better detected using the proposed AC/DC monkey coil.

PURPOSE: B(1)(+) and T(1) corrections and dynamic multi-coil shimming approaches were proposed to improve the fidelity of high isotropic resolution Generalized slice dithered enhanced resolution (gSlider) diffusion imaging. METHODS: An extended reconstruction incorporating B(1)(+) inhomogeneity and T(1) recovery information was developed to mitigate slab-boundary artifacts in short-TR gSlider acquisitions. Slab-by-slab dynamic B0 shimming using a multi-coil integrated ΔB(0)/Rx shim-array, and high in-plane acceleration (R(inplane)=4) achieved with virtual-coil GRAPPA were also incorporated into a 1 mm isotropic resolution gSlider acquisition/reconstruction framework to achieve a significant reduction in geometric distortion compared to single-shot EPI. RESULTS: The slab-boundary artifacts were alleviated by the proposed B(1)(+) and T(1) corrections compared to the standard gSlider reconstruction pipeline for short-TR acquisitions. Dynamic shimming provided >50% reduction in geometric distortion compared to conventional global 2(nd) order shimming. 1 mm isotropic resolution diffusion data show that the typically problematic temporal and frontal lobes of the brain can be imaged with high geometric fidelity using dynamic shimming. CONCLUSIONS: The proposed B(1)(+) and T(1) corrections and local-field control substantially improved the fidelity of high isotropic resolution diffusion imaging, with reduced slab-boundary artifacts and geometric distortion compared to conventional gSlider acquisition and reconstruction. This enabled high-fidelity whole-brain 1 mm isotropic diffusion imaging with 64 diffusion-directions in 20 minutes using a 3T clinical scanner.

This paper presents models, designs, and simulation results for logic circuits based upon graphene ballistic deflection transistors (GBDTs). The use of graphene in conventional semiconductor circuits has proved difficult due to its negligible bandgap. GBDTs might avoid this deficiency by electrostatically steering currents through graphene's highly conductive two-dimensional charge transport medium. Simulation results are presented for a GBDT-based inverter and full adder that are predicted to operate twice as fast as conventional CMOS circuits, at the cost of much lower transistor density. The GBDT-based circuits presented in this paper would be well suited for high-speed, high-duty-cycle applications, including high-throughput networking and high-performance computing.