1. Efficient radiosynthesis of a [18F]-phosphonium salt containing closo-carborane
- Author
-
Daniel E. Morrison, Michael Kassiou, Joseph A. Ioppolo, Nicolas Giboureau, Louis M. Rendina, and Mohan M. Bhadbhade
- Subjects
Cluster chemistry ,cluster chemistry ,PET imaging ,Phosphonium salt ,chemistry.chemical_element ,Boron clusters ,010402 general chemistry ,01 natural sciences ,Biochemistry ,110302 - Clinical Chemistry (diagnostics) [FoR] ,radiolabelling ,030205 - Non-metal Chemistry [FoR] ,chemistry.chemical_compound ,carborane ,Drug Discovery ,Organic chemistry ,Phosphonium ,clusters ,Boron ,010405 organic chemistry ,Organic Chemistry ,Radiosynthesis ,030299 - Inorganic Chemistry not elsewhere classified [FoR] ,Pet imaging ,phosphonium ,0104 chemical sciences ,boron clusters ,18F ,chemistry ,fluorine-18 ,Carborane ,radiosynthesis ,boron ,110320 - Radiology and Organ Imaging [FoR] - Abstract
An efficient synthesis of an 18F-labelled phosphonium salt containing closo-carborane is described. The preparation of this salt was attempted using both single-step and two-step protocols, with greater success found for the latter. An X-ray structure for the unlabelled 19F salt is also presented. Australian Research Council (ARC)
- Published
- 2017