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6. Presumed Ocular Histoplasmosis Syndrome

Author

Neri, Piergiorgio, Arapi, Ilir, Pirani, Vittorio, Nicolai, Michele, Saitta, Andrea, Mariotti, Cesare, Giovannini, Alfonso, Gupta, Vishali, editor, Nguyen, Quan Dong, editor, LeHoang, Phuc, editor, and Agarwal, Aniruddha, editor

Published
2020
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10. Presumed Ocular Histoplasmosis Syndrome

Author

Neri, Piergiorgio, primary, Arapi, Ilir, additional, Pirani, Vittorio, additional, Nicolai, Michele, additional, Saitta, Andrea, additional, Mariotti, Cesare, additional, and Giovannini, Alfonso, additional

Published
2019
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13. Posterior Uveitis

Author

Neri, Piergiorgio, Arapi, Ilir, Pleyer, Uwe, Khairallah, Moncef, Basu, Soumyava, Nicolai, Michele, Pirani, Vittorio, Giovannini, Alfonso, Mariotti, Cesare, Pleyer, Uwe, editor, Alió, Jorge L., editor, Barisani-Asenbauer, Talin, editor, Le Hoang, Phuc, editor, and Rao, Narsing A., editor

Published
2014
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14. Quantification of Carbonic Anhydrase Inhibitors and Metabolites in Urine and Hair of Patients and Their Relatives

Author

Lo Faro, Alfredo Fabrizio, primary, Tini, Anastasio, additional, Bambagiotti, Giulia, additional, Pirani, Filippo, additional, Faragalli, Andrea, additional, Carle, Flavia, additional, Pacella, Elena, additional, Ceka, Artan, additional, Moretti, Marco, additional, Gottardi, Massimo, additional, Lassandro, Nicola Vito, additional, Nicolai, Michele, additional, Lupidi, Marco, additional, Mariotti, Cesare, additional, Busardò, Francesco Paolo, additional, and Carlier, Jeremy, additional

Published
2022
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21. Presumed Ocular Histoplasmosis Syndrome

Author

Neri, Piergiorgio, primary, Arapi, Ilir, additional, Pirani, Vittorio, additional, Nicolai, Michele, additional, Saitta, Andrea, additional, Mariotti, Cesare, additional, and Giovannini, Alfonso, additional

Published
2016
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27. Effect of COVID-19-related lockdown on ophthalmic practice in Italy: A report from 39 institutional centers

Author

dell’Omo, Roberto, primary, Filippelli, Mariaelena, additional, Virgili, Gianni, additional, Bandello, Francesco, additional, Querques, Giuseppe, additional, Lanzetta, Paolo, additional, Avitabile, Teresio, additional, Viola, Francesco, additional, Reibaldi, Michele, additional, Semeraro, Francesco, additional, Quaranta, Luciano, additional, Rizzo, Stanislao, additional, Midena, Edoardo, additional, Campagna, Giuseppe, additional, Costagliola, Ciro, additional, Marolo, Paola, additional, Traverso, Carlo Enrico, additional, Iester, Michele, additional, Cutolo, Carlo Alberto, additional, Azzolini, Claudio, additional, Donati, Simone, additional, Premi, Elias, additional, Nucci, Paolo, additional, Vujosevic, Stela, additional, Staurenghi, Giovanni, additional, Bottoni, Ferdinando, additional, Romano, Francesco, additional, Grosso, Domenico, additional, Borrelli, Enrico, additional, Sacconi, Riccardo, additional, Milella, Paolo, additional, Ganci, Simone, additional, Romano, Mario R., additional, Ricciardelli, Gabriella, additional, Allegrini, Davide, additional, Casaluci, Marco, additional, Romano, Davide, additional, Marchini, Giorgio, additional, Chemello, Francesca, additional, Amantea, Camilla, additional, Frisina, Rino, additional, Pilotto, Elisabetta, additional, Parrozzani, Raffaele, additional, Veritti, Daniele, additional, Sarao, Valentina, additional, Daniele, Tognetto, additional, Busin, Massimo, additional, Parmeggiani, Francesco, additional, De Nadai, Katia, additional, Furiosi, Luca, additional, Mastropasqua, Rodolfo, additional, Battaglia, Bruno, additional, Gironi, Matteo, additional, Gandolfi, Stefano, additional, Luciani, Enrico, additional, Mora, Paolo, additional, Schiavi, Costantino, additional, Bertaccini, Patrizia, additional, Finzi, Alessandro, additional, Roda, Matilde, additional, Cagini, Carlo, additional, Lupidi, Marco, additional, Giansanti, Fabrizio, additional, Bacherini, Daniela, additional, Tosi, Gianmarco, additional, De Benedetto, Elena, additional, Nardi, Marco, additional, Figus, Michele, additional, Posarelli, Chiara, additional, Mariotti, Cesare, additional, Pirani, Vittorio, additional, Nicolai, Michele, additional, Bonini, Stefano, additional, Coassin, Marco, additional, Di Zazzo, Antonio, additional, Savastano, Mariacristina, additional, Savastano, Alfonso, additional, Gambini, Gloria, additional, Vico, Umberto De, additional, Spadea, Leopoldo, additional, Iannaccone, Andrea, additional, Nucci, Carlo, additional, Ricci, Federico, additional, Aiello, Francesco, additional, Afflitto, Gabriele Gallo, additional, Mastropasqua, Leonardo, additional, D’Onofio, Giada, additional, Evangelista, Federica, additional, Brescia, Lorenza, additional, Napolitano, Pasquale, additional, Polisena, Paolo, additional, Gianfrancesco, Nicolina, additional, Trivisonno, Domenico, additional, Petti, Francesco, additional, Simonelli, Francesca, additional, Rossi, Settimio, additional, Tartaglione, Antonio, additional, Rosa, Nicola, additional, Bernardo, Maddalena De, additional, Iaculli, Cristiana, additional, Valeria Bux, Anna, additional, Maggiore, Giulia, additional, Boscia, Francesco, additional, Sborgia, Giancarlo, additional, Grassi, Maria Oliva, additional, Scorcia, Vincenzo, additional, Giannaccare, Giuseppe, additional, Parisi, Guglielmo, additional, Cillino, Salvatore, additional, Alaimo, Francesco, additional, Aragona, Pasquale, additional, Meduri, Alessandro, additional, Pinna, Antonio, additional, Sollazzo, Andrea, additional, Peiretti, Enrico, additional, and Siotto, Emanuele, additional

Published
2021
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36. Effect of COVID-19-related lockdown on ophthalmic practice in Italy: A report from 39 institutional centers

Author

dell’Omo, Roberto, Filippelli, Mariaelena, Virgili, Gianni, Bandello, Francesco, Querques, Giuseppe, Lanzetta, Paolo, Avitabile, Teresio, Viola, Francesco, Reibaldi, Michele, Semeraro, Francesco, Quaranta, Luciano, Rizzo, Stanislao, Midena, Edoardo, Campagna, Giuseppe, Costagliola, Ciro, Marolo, Paola, Traverso, Carlo Enrico, Iester, Michele, Cutolo, Carlo Alberto, Azzolini, Claudio, Donati, Simone, Premi, Elias, Nucci, Paolo, Vujosevic, Stela, Staurenghi, Giovanni, Bottoni, Ferdinando, Romano, Francesco, Grosso, Domenico, Borrelli, Enrico, Sacconi, Riccardo, Milella, Paolo, Ganci, Simone, Romano, Mario R., Ricciardelli, Gabriella, Allegrini, Davide, Casaluci, Marco, Romano, Davide, Marchini, Giorgio, Chemello, Francesca, Amantea, Camilla, Frisina, Rino, Pilotto, Elisabetta, Parrozzani, Raffaele, Veritti, Daniele, Sarao, Valentina, Daniele, Tognetto, Busin, Massimo, Parmeggiani, Francesco, De Nadai, Katia, Furiosi, Luca, Mastropasqua, Rodolfo, Battaglia, Bruno, Gironi, Matteo, Gandolfi, Stefano, Luciani, Enrico, Mora, Paolo, Schiavi, Costantino, Bertaccini, Patrizia, Finzi, Alessandro, Roda, Matilde, Cagini, Carlo, Lupidi, Marco, Giansanti, Fabrizio, Bacherini, Daniela, Tosi, Gianmarco, De Benedetto, Elena, Nardi, Marco, Figus, Michele, Posarelli, Chiara, Mariotti, Cesare, Pirani, Vittorio, Nicolai, Michele, Bonini, Stefano, Coassin, Marco, Di Zazzo, Antonio, Savastano, Mariacristina, Savastano, Alfonso, Gambini, Gloria, Vico, Umberto De, Spadea, Leopoldo, Iannaccone, Andrea, Nucci, Carlo, Ricci, Federico, Aiello, Francesco, Afflitto, Gabriele Gallo, Mastropasqua, Leonardo, D’Onofio, Giada, Evangelista, Federica, Brescia, Lorenza, Napolitano, Pasquale, Polisena, Paolo, Gianfrancesco, Nicolina, Trivisonno, Domenico, Petti, Francesco, Simonelli, Francesca, Rossi, Settimio, Tartaglione, Antonio, Rosa, Nicola, Bernardo, Maddalena De, Iaculli, Cristiana, Valeria Bux, Anna, Maggiore, Giulia, Boscia, Francesco, Sborgia, Giancarlo, Grassi, Maria Oliva, Scorcia, Vincenzo, Giannaccare, Giuseppe, Parisi, Guglielmo, Cillino, Salvatore, Alaimo, Francesco, Aragona, Pasquale, Meduri, Alessandro, Pinna, Antonio, Sollazzo, Andrea, Peiretti, Enrico, and Siotto, Emanuele

Abstract

Background/objectives: To compare the number of eye surgical procedures performed in Italy in the 2 months following the beginning of lockdown (study period) because of COVID-19 epidemic with those performed in the two earlier months of the same year (intra-year control) and in the period of 2019 corresponding to the lockdown (inter-year control).Methods: Retrospective analysis of surgical procedures carried out at 39 Academic hospitals. A distinction was made between elective and urgent procedures. Intravitreal injections were also considered. Percentages for all surgical procedures and incidence rate ratios (IRR) for rhegmatogenous retinal detachment (RRD) events were calculated. A pvalue <0.05 was considered significant.Results: A total of 20,886 versus 55,259 and 56,640 patients underwent surgery during the lockdown versus intra-and inter-year control periods, respectively. During the lockdown, only 70% of patients for whom an operation/intravitreal injection was recommended, finally underwent surgery; the remaining patients did not attend because afraid of getting infected at the hospital (23%), taking public transportation (6.5%), or unavailable swabs (0.5%). Elective surgeries were reduced by 96.2% and 96.4%, urgent surgeries by 49.7% and 50.2%, and intravitreal injections by 48.5% and 48.6% in the lockdown period in comparison to intra-year and inter-year control periods, respectively. IRRs for RRDs during lockdown dropped significantly in comparison with intra- and inter-year control periods (CI: 0.65–0.80 and 0.61–0.75, respectively, p< 0.001 for both).Conclusion: This study provides a quantitative analysis of the reduction of eye surgical procedures performed in Italy because of the COVID-19 epidemic.

Published
2022
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37. DNA and S-phase fraction analysis by flow cytometry in prostate cancer: clinicopathologic implications

Author

Tinari, Nicola, Natoli, Clara, Angelucci, Domenico, Tenaglia, Raffaele, Fiorentino, Bruno, Di Stefano, Pia, Amatetti, Cristina, Zezza, Andrea, Nicolai, Michele, and Iacobelli, Stefano

Subjects
Prostate cancer -- Prognosis, Flow cytometry -- Usage, Aged men -- Patient outcomes, Ploidy -- Analysis, Health
Abstract

Background. Available prognostic factors for prostate cancer have not been proven consistently useful. The authors evaluated the prognostic value of DNA analysis by flow cytometry (FCM) in prostate cancer. Methods. Paraffin-embedded tumor specimens taken at tru-cut biopsy or transurethral resection (TURP) from 81 patients with prostate cancer were analyzed for DNA content and S-phase fraction (SPF) by FCM according to the method of Hedley et al (1983). Results. Thirty-five of the 63 (55.5%) evaluable DNA histograms had a diploid pattern, 18 (28.5%) a distinct aneuploid peak, and 10 (16%) a tetraploid pattern. An association was establish between DNA ploidy abnormalities and Gleason score (P < 0.04) or presence of metastases at diagnosis (P < 0.0002). At Kaplan-Meier analysis, overall survival was significantly longer (P < 0.0002) in patients with diploid than in those with nondiploid tumors. Among patients with different risk categories, i.e., tumor sizes, Gleason score, and metastases at presentation, ploidy improved the detection of patients with poorer survival, with the exception of those with T1-T2 tumors. Cox regression analysis showed that ploidy was significantly related to survival. Bivariate models containing ploidy and SPF or Gleason score had a predictive value similar to that including all variables. Conclusion. The study data show that DNA ploidy provides additional prognostic information in patients with locally advanced or metastatic prostatic cancer. The role of SPF remains to be established. Cancer 1993; 71:1289-96.

Published
1993

39. Juxtapapillary Retinal Capillary Hemangioma: New Therapeutic Strategies

Author

Saitta, Andrea, Nicolai, Michele, Giovannini, Alfonso, and Mariotti, Cesare

Subjects
Therapeutic Strategies, Juxtapapillary Retinal Capillary Hemangioma, Papillomacular Bundle, sense organs, Review Article, eye diseases
Abstract

The treatment of juxtapapillary retinal capillary hemangiomas (JRCHs) is still a therapeutic dilemma without established guidelines. Because of the location of these hemangiomas on or adjacent to the optic nerve, treatment is difficult and complex, especially when JRCHs are located in the papillomacular bundle. This manuscript reviews the clinically relevant data on literature regarding the treatment of JRCHs, focusing on novel combined therapies that have shown promising results in these lesions.

Published
2014

41. Leydig Cell Tumor in a 53-Year-Old Patient with Gynecomastia and Gynecodynia: A Case Report and Literature Review

Author

De Francesco, Piergustavo, primary, Ghahhari, Jamil, additional, Castellan, Pietro, additional, Nicolai, Michele, additional, De Luca, Graziano, additional, Marchioni, Michele, additional, Primiceri, Giulia, additional, Rizzoli, Ambra, additional, D'orta, Carlo, additional, Ingrosso, Manuela, additional, Berardinelli, Francesco, additional, Cindolo, Luca, additional, and Schips, Luigi, additional

Published
2017
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44. Reply

Author

Mariotti, Cesare, primary and Nicolai, Michele, additional

Published
2016
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47. TRANSCONJUNCTIVAL NONVITRECTOMIZING VITREOUS SURGERY VERSUS 25-GAUGE VITRECTOMY IN PATIENTS WITH EPIRETINAL MEMBRANE

Author

Reibaldi, Michele, primary, Longo, Antonio, additional, Avitabile, Teresio, additional, Bonfiglio, Vincenza, additional, Toro, Mario D., additional, Russo, Andrea, additional, Viti, Francesca, additional, Nicolai, Michele, additional, Saitta, Andrea, additional, Giovannini, Alfonso, additional, and Mariotti, Cesare, additional

Published
2015
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50. Epiretinal membrane surgery for combined hamartoma of the retina and retinal pigment epithelium: role of multimodal analysis

Author

Bruè,Claudia, Saitta,Andrea, Nicolai,Michele, Mariotti,Cesare, Giovannini,Alfonso, Bruè,Claudia, Saitta,Andrea, Nicolai,Michele, Mariotti,Cesare, and Giovannini,Alfonso

Abstract

Claudia Bruè, Andrea Saitta, Michele Nicolai, Cesare Mariotti, Alfonso GiovanniniOphthalmology, Department of Neuroscience, Marche Polytechnic University, Ancona, ItalyBackground: The purpose of this study was to evaluate the role of spectral domain optical coherence tomography (SD-OCT), MP-1 microperimetry, and fundus autofluorescence imaging for planning surgical procedures in combined hamartomas of the retina and retinal pigment epithelium (CHR-RPE) and following epiretinal membrane removal.Methods: In an interventional retrospective case series, six consecutive subjects with CHR-RPE underwent vitrectomy and epiretinal membrane peeling, with 4 years of follow-up. Each underwent complete ophthalmic examination, including best corrected visual acuity, fundus examination, fundus fluorescein angiography, SD-OCT, MP-1, and fundus autofluorescence at one, 6, 12, and 48 months.Results: Six eyes from six subjects with CHR-RPE were studied (mean age 31 ± 14 years). All patients were phakic and five were male (83.3%). Lesions were unilateral, ie, three macular, two juxtapapillary and macular, and one pericentral. Preoperative best corrected visual acuity was 0.3 ± 0.08 Snellen, with significant improvement to 0.9 ± 0.17 Snellen (P = 0.001) at 4 years of follow-up. Mean retinal sensitivity within the central 20° field improved from 16.6 ± 1.84 dB to 18.8 ± 0.96 dB (P = 0.07). There was also a statistically significant reduction in the visual defect (P = 0.04). SD-OCT demonstrated that the epiretinal membranes were completely removed in all but one patient, with significantly decreased macular edema on follow-up at one, 6, 12, and 48 months (P = 0.001). A positive correlation was shown between preoperative macular sensitivity and postoperative best corrected visual acuity. Fundus autofluorescence demonstrated a block in background autofluorescence at the site of the lesion, and hyperautofluorescsence a

Published
2013

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