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2. Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene

Author

Gupta, Rohini, Dittmeier, Melanie, Wohlleben, Gisela, Nickl, Vera, Bischler, Thorsten, Luzak, Vanessa, Wegat, Vanessa, Doll, Dennis, Sodmann, Annemarie, Bady, Elena, Langlhofer, Georg, Wachter, Britta, Havlicek, Steven, Gupta, Jahnve, Horn, Evi, Lüningschrör, Patrick, Villmann, Carmen, Polat, Bülent, Wischhusen, Jörg, Monoranu, Camelia M., Kuper, Jochen, and Blum, Robert

Published
2024
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6. Cultivating Ex Vivo Patient-Derived Glioma Organoids Using a Tissue Chopper

Author

Alsalkini, Marah, primary, Cibulková, Veronika, additional, Breun, Maria, additional, Kessler, Almuth F., additional, Schulz, Tim, additional, Cattaneo, Andrea, additional, Wipplinger, Christoph, additional, Hübner, Julian, additional, Ernestus, Ralf-Ingo, additional, Nerreter, Thomas, additional, Monoranu, Camelia M., additional, Hagemann, Carsten, additional, Löhr, Mario, additional, and Nickl, Vera, additional

Published
2024
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7. Analysis of tumor microenvironment composition in vestibular schwannomas: insights into NF2-associated and sporadic variations and their clinical correlations.

Author

Nickl, Vera, Ziebolz, David, Rumpel, Charlotte, Klein, Dennis, Nickl, Robert, Rampeltshammer, Eva, Monoranu, Camelia M., Ernestus, Ralf-Ingo, Matthies, Cordula, Löhr, Mario, Hagemann, Carsten, and Breun, Maria

Subjects
SCHWANNOMAS, TUMOR microenvironment, NEUROFIBROMATOSIS 2, ACOUSTIC nerve, REGULATORY T cells, KILLER cells
Abstract

Objective: Vestibular schwannomas (VS), benign tumors stemming from the eighth cranial nerve's Schwann cells, are associated with Merlin gene mutations, inflammation, and the tumor microenvironment (TME), influencing tumor initiation, maintenance, and potential neural dysfunction. Understanding TME composition holds promise for systemic therapeutic interventions, particularly for NF2-related schwannomatosis. Methodology: A retrospective analysis of paraffin-embedded tissue from 40 patients (2013-2020), evenly divided by neurofibromatosis type 2 status, with further stratification based on magnetic resonance imaging (MRI) progression and hearing function. Immunohistochemistry assessed TME components, including T-cell markers (CD4, CD8, CD25), NK cells (CD7), and macrophages (CD14, CD68, CD163, CCR2). Fiji software facilitated image analysis. Results: T-cell markers (CD4, CD8, CD7) exhibited low expression in VS, with no significant NF2-associated vs. sporadic distinctions. Macrophage-related markers (CD14, CD68, CD163, CCR2) showed significantly higher expression (CD14: p = 0.0187, CD68: p < 0.0001, CD163: p = 0.0006, CCR2: p < 0.0001). CCR2 and CD163 significantly differed between NF2-associated and sporadic VS. iNOS, an M1-macrophage marker, was downregulated. CD25, a regulatory T-cell marker, correlated significantly with tumor growth dynamics (p = 0.016). Discussion: Immune cells, notably monocytes and macrophages, crucially contribute to VS pathogenesis in both NF2-associated and sporadic cases. Significant differences in CCR2 and CD163 expression suggest distinct immune responses. Regulatory T-cells may serve as growth dynamic markers. These findings highlight immune cells as potential biomarkers and therapeutic targets for managing VS. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Characterization and Optimization of the Tumor Microenvironment in Patient-Derived Organotypic Slices and Organoid Models of Glioblastoma

Author

Nickl, Vera, primary, Eck, Juliana, additional, Goedert, Nicolas, additional, Hübner, Julian, additional, Nerreter, Thomas, additional, Hagemann, Carsten, additional, Ernestus, Ralf-Ingo, additional, Schulz, Tim, additional, Nickl, Robert Carl, additional, Keßler, Almuth Friederike, additional, Löhr, Mario, additional, Rosenwald, Andreas, additional, Breun, Maria, additional, and Monoranu, Camelia Maria, additional

Published
2023
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9. Abstract 4573: Evaluation of tumor treating fields (TTFields) effects at 200 kHz on a glioblastoma, an anaplastic ependymoma and an oligodendroglioma sample in a patient-derived ex vivo organoid model

Author

Nickl, Vera, primary, Schulz, Ellina, additional, Salvador, Ellaine, additional, Trautmann, Laureen, additional, Diener, Leopold, additional, Kessler, Almuth F., additional, Monoranu, Camelia M., additional, Ernestus, Ralf-Ingo, additional, Löhr, Mario, additional, and Hagemann, Carsten, additional

Published
2023
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10. A Combination of CAR-T Cell Specificities Can Overcome Antigen Escape Mechanisms in Ex Vivo Glioblastoma Models

Author

Alsalkini, Marah, primary, Hübner, Julian, additional, Diener, Leopold, additional, Monoranu, Camelia, additional, Cattaneo, Andrea, additional, Keßler, Almuth, additional, Schulz, Tim, additional, Hagemann, Carsten, additional, Ernestus, Ralf-Ingo, additional, Löhr, Mario, additional, Breun, Maria, additional, Nerreter, Thomas, additional, and Nickl, Vera, additional

Published
2023
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12. TMEM119-Positive Microglial Cells in Cerebrospinal Fluid as a Possible Marker for the Inflammatory Response After Aneurysmal Subarachnoid Hemorrhage, a Preliminary Study

Author

Cattaneo, Andrea, primary, Monoranu, Camelia-Maria, additional, Messinger, Julia, additional, Löhr, Mario, additional, Wipplinger, Christoph, additional, Weiland, Judith, additional, Kunze, Ekkehard, additional, Stetter, Christian, additional, Linsenmann, Thomas, additional, Nickl, Vera, additional, Heinsen, Helmut, additional, Bohnert, Michael, additional, Ernestus, Ralf-Ingo, additional, and Bohnert, Simone, additional

Published
2023
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13. CAR-T Cells Against Three Novel Antigens Show Antitumoral Efficacy in Ex Vivo Patient Derived Glioblastoma Organoids

Author

Diener, Leopold, primary, Goedert, Nicolas, additional, Alskalini, Marah, additional, Cattaneo, Andrea, additional, Monoranu, Camelia, additional, Hübner, Julian, additional, Schulz, Tim, additional, Keßler, Almuth, additional, Ernestus, Ralf-Ingo, additional, Hagemann, Carsten, additional, Löhr, Mario, additional, Breun, Maria, additional, Nerreter, Thomas, additional, and Nickl, Vera, additional

Published
2023
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14. Glioblastoma-Derived Three-Dimensional Ex Vivo Models to Evaluate Effects and Efficacy of Tumor Treating Fields (TTFields)

Author

Nickl, Vera, primary, Schulz, Ellina, additional, Salvador, Ellaine, additional, Trautmann, Laureen, additional, Diener, Leopold, additional, Kessler, Almuth F., additional, Monoranu, Camelia M., additional, Dehghani, Faramarz, additional, Ernestus, Ralf-Ingo, additional, Löhr, Mario, additional, and Hagemann, Carsten, additional

Published
2022
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20. Pearls & Oy-sters: INO Plus From Downward Herniation-A Cautionary Tale Regarding Neuro-Ophthalmologic Signatures of Brainstem Compression.

Author

Hartig J, Nickl V, Vollmuth C, Weiner S, Pham M, Volkmann J, Friedrich MU, Kunze E, and Ip CW

Subjects
Humans, Brain Stem diagnostic imaging, Male, Magnetic Resonance Imaging, Female, Aged, Ocular Motility Disorders etiology
Abstract

Pupillary assessment is a quintessential part of the clinical examination in neuro-intensive care patients because it provides insight into the integrity of midbrain reflex arcs. Abnormal pupils, particularly anisocoria and later bilateral fixed mydriasis, are classically used to assess expansive intracranial processes because they are frequently considered early indicators of transtentorial midbrain compression due to elevated intracranial pressure. Complex ocular motor deficits mapping to the midbrain are rarely described in the setting of high transtentorial pressure. This is likely because ocular motor deficits typically occur in conjunction with decreased consciousness and corticospinal tract dysfunction reflecting advanced midbrain compromise. We present a case of left midbrain compression due to downward herniation in a patient with acute-on-chronic bilateral subdural hematoma. Ocular motor assessment demonstrated left internuclear ophthalmoplegia (INO) and an ocular tilt reaction, termed INO plus. However, pupillary, mental status, and sensorimotor examinations were unremarkable. Head magnetic resonance imaging revealed acute perforator ischemia in the left pontomesencephalic tegmentum, localizing to the ipsilateral medial longitudinal fasciculus and graviceptive oculocephalic circuits. Microvascular compromise secondary to mechanical pressure is discussed as a causative mechanism. We caution against overreliance on "telltale pupils" in suspected brainstem compression and recommend checking for other oculomotor signs.

Published
2024
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