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1. Ensembl Genomes 2022: an expanding genome resource for non-vertebrates.

Author

Andrew D. Yates, James E. Allen, M. Ridwan Amode, Andrey G. Azov, Matthieu Barba, Andrés Becerra, Jyothish Bhai, Lahcen I. Campbell, Manuel Carbajo Martinez, Marc Chakiachvili, Kapeel Chougule, Mikkel B. Christensen, Bruno Contreras-Moreira, Alayne Cuzick, Luca Da Rin Fioretto, Paul Davis 0001, Nishadi De Silva, Stavros Diamantakis, Sarah Dyer, Justin Elser, Carla V. Filippi, Astrid Gall, Dionysios Grigoriadis, Cristina Guijarro-Clarke, Parul Gupta, Kim E. Hammond-Kosack, Kevin L. Howe, Pankaj Jaiswal, Vinay Kaikala, Vivek Kumar, Sunita Kumari, Nick Langridge, Tuan Le, Manuel Luypaert, Gareth Maslen, Thomas Maurel, Benjamin Moore, Matthieu Muffato, Aleena Mushtaq, Guy Naamati, Sushma Naithani, Andrew Olson, Anne Parker, Michael Paulini, Helder Pedro, Emily Perry, Justin Preece, Mark Quinton-Tulloch, Faye Rodgers, Marc Rosello, Magali Ruffier, James Seager, Vasily Sitnik, Michal Szpak, John G. Tate, Marcela K. Tello-Ruiz, Stephen J. Trevanion, Martin Urban, Doreen Ware, Sharon Wei, Gary Williams, Andrea Winterbottom, Magdalena Zarowiecki, Robert D. Finn, and Paul Flicek

Published
2022
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2. Ensembl 2021.

Author

Kevin L. Howe, Premanand Achuthan, James E. Allen, Jamie Allen, Jorge álvarez-Jarreta, M. Ridwan Amode, Irina M. Armean, Andrey G. Azov, Ruth Bennett, Jyothish Bhai, Konstantinos Billis, Sanjay Boddu, Mehrnaz Charkhchi, Carla A. Cummins, Luca Da Rin Fioretto, Claire Davidson, Kamalkumar Jayantilal Dodiya, Bilal El Houdaigui, Reham Fatima, Astrid Gall, Carlos García-Girón, Tiago Grego, Cristina Guijarro-Clarke, Leanne Haggerty, Anmol Hemrom, Thibaut Hourlier, Osagie G. Izuogu, Thomas Juettemann, Vinay Kaikala, Mike P. Kay, Ilias Lavidas, Tuan Le, Diana Lemos, Jose Gonzalez Martinez, José Carlos Marugán, Thomas Maurel, Aoife C. McMahon, Shamika Mohanan, Benjamin Moore, Matthieu Muffato, Denye N. Oheh, Dimitrios Paraschas, Anne Parker, Andrew Parton, Irina Prosovetskaia, Manoj Pandian Sakthivel, Ahamed Imran Abdul Salam, Bianca M. Schmitt, Helen Schuilenburg, Dan Sheppard, Emily Steed, Michal Szpak, Marek Szuba, Kieron R. Taylor, Anja Thormann, Glen Threadgold, Brandon Walts, Andrea Winterbottom, Marc Chakiachvili, Ameya Chaubal, Nishadi De Silva, Bethany Flint, Adam Frankish, Sarah E. Hunt, Garth IIsley, Nick Langridge, Jane E. Loveland, Fergal J. Martin, Jonathan M. Mudge, Joannella Morales, Emily Perry, Magali Ruffier, John G. Tate, David Thybert, Stephen J. Trevanion, Fiona Cunningham, Andrew D. Yates, Daniel R. Zerbino, and Paul Flicek

Published
2021
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3. Ensembl 2020.

Author

Andrew D. Yates, Premanand Achuthan, Wasiu A. Akanni, James E. Allen, Jamie Allen, Jorge álvarez-Jarreta, M. Ridwan Amode, Irina M. Armean, Andrey G. Azov, Ruth Bennett, Jyothish Bhai, Konstantinos Billis, Sanjay Boddu, José Carlos Marugán, Carla A. Cummins, Claire Davidson, Kamalkumar Jayantilal Dodiya, Reham Fatima, Astrid Gall, Carlos García-Girón, Laurent Gil, Tiago Grego, Leanne Haggerty, Erin Haskell, Thibaut Hourlier, Osagie G. Izuogu, Sophie H. Janacek, Thomas Juettemann, Mike P. Kay, Ilias Lavidas, Tuan Le, Diana Lemos, Jose Gonzalez Martinez, Thomas Maurel, Mark D. McDowall, Aoife McMahon, Shamika Mohanan, Benjamin Moore, Michael Nuhn, Denye N. Oheh, Anne Parker, Andrew Parton, Mateus Patricio, Manoj Pandian Sakthivel, Ahamed Imran Abdul Salam, Bianca M. Schmitt, Helen Schuilenburg, Dan Sheppard, Mira Sycheva, Marek Szuba, Kieron R. Taylor, Anja Thormann, Glen Threadgold, Alessandro Vullo, Brandon Walts, Andrea Winterbottom, Amonida Zadissa, Marc Chakiachvili, Bethany Flint, Adam Frankish, Sarah E. Hunt, Garth IIsley, Myrto Kostadima, Nick Langridge, Jane E. Loveland, Fergal J. Martin, Joannella Morales, Jonathan M. Mudge, Matthieu Muffato, Emily Perry, Magali Ruffier, Stephen J. Trevanion, Fiona Cunningham, Kevin L. Howe, Daniel R. Zerbino, and Paul Flicek

Published
2020
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4. Ensembl Genomes 2020 - enabling non-vertebrate genomic research.

Author

Kevin L. Howe, Bruno Contreras-Moreira, Nishadi De Silva, Gareth Maslen, Wasiu A. Akanni, James E. Allen, Jorge álvarez-Jarreta, Matthieu Barba, Dan M. Bolser, Lahcen Cambell, Manuel Carbajo, Marc Chakiachvili, Mikkel B. Christensen, Carla A. Cummins, Alayne Cuzick, Paul Davis 0001, Silvie Fexova, Astrid Gall, Nancy George, Laurent Gil, Parul Gupta, Kim E. Hammond-Kosack, Erin Haskell, Sarah E. Hunt, Pankaj Jaiswal, Sophie H. Janacek, Paul J. Kersey, Nick Langridge, Uma Maheswari, Thomas Maurel, Mark D. McDowall, Benjamin Moore, Matthieu Muffato, Guy Naamati, Sushma Naithani, Andrew Olson, Irene Papatheodorou, Mateus Patricio, Michael Paulini, Helder Pedro, Emily Perry, Justin Preece, Marc Rosello, Matthew Russell, Vasily Sitnik, Daniel M. Staines, Joshua C. Stein, Marcela K. Tello-Ruiz, Stephen J. Trevanion, Martin Urban, Sharon Wei, Doreen Ware, Gary Williams, Andrew D. Yates, and Paul Flicek

Published
2020
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5. Ensembl 2019.

Author

Fiona Cunningham, Premanand Achuthan, Wasiu A. Akanni, James E. Allen, M. Ridwan Amode, Irina M. Armean, Ruth Bennett, Jyothish Bhai, Konstantinos Billis, Sanjay Boddu, Carla A. Cummins, Claire Davidson, Kamalkumar Jayantilal Dodiya, Astrid Gall, Carlos García-Girón, Laurent Gil, Tiago Grego, Leanne Haggerty, Erin Haskell, Thibaut Hourlier, Osagie G. Izuogu, Sophie H. Janacek, Thomas Juettemann, Mike P. Kay, Matthew R. Laird, Ilias Lavidas, Zhicheng Liu, Jane E. Loveland, José Carlos Marugán, Thomas Maurel, Aoife C. McMahon, Benjamin Moore, Joannella Morales, Jonathan M. Mudge, Michael Nuhn, Denye N. Ogeh, Anne Parker, Andrew Parton, Mateus Patricio, Ahamed Imran Abdul Salam, Bianca M. Schmitt, Helen Schuilenburg, Daniel Sheppard, Helen Sparrow, Eloise Stapleton, Marek Szuba, Kieron R. Taylor, Glen Threadgold, Anja Thormann, Alessandro Vullo, Brandon Walts, Andrea Winterbottom, Amonida Zadissa, Marc Chakiachvili, Adam Frankish, Sarah E. Hunt, Myrto Kostadima, Nick Langridge, Fergal J. Martin, Matthieu Muffato, Emily Perry, Magali Ruffier, Daniel M. Staines, Stephen J. Trevanion, Bronwen L. Aken, Andrew D. Yates, Daniel R. Zerbino, and Paul Flicek

Published
2019
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6. Ensembl 2021

Author

Kevin L Howe, Premanand Achuthan, James Allen, Jamie Allen, Jorge Alvarez-Jarreta, M Ridwan Amode, Irina M Armean, Andrey G Azov, Ruth Bennett, Jyothish Bhai, Konstantinos Billis, Sanjay Boddu, Mehrnaz Charkhchi, Carla Cummins, Luca Da Rin Fioretto, Claire Davidson, Kamalkumar Dodiya, Bilal El Houdaigui, Reham Fatima, Astrid Gall, Carlos Garcia Giron, Tiago Grego, Cristina Guijarro-Clarke, Leanne Haggerty, Anmol Hemrom, Thibaut Hourlier, Osagie G Izuogu, Thomas Juettemann, Vinay Kaikala, Mike Kay, Ilias Lavidas, Tuan Le, Diana Lemos, Jose Gonzalez Martinez, José Carlos Marugán, Thomas Maurel, Aoife C McMahon, Shamika Mohanan, Benjamin Moore, Matthieu Muffato, Denye N Oheh, Dimitrios Paraschas, Anne Parker, Andrew Parton, Irina Prosovetskaia, Manoj P Sakthivel, Ahamed I Abdul Salam, Bianca M Schmitt, Helen Schuilenburg, Dan Sheppard, Emily Steed, Michal Szpak, Marek Szuba, Kieron Taylor, Anja Thormann, Glen Threadgold, Brandon Walts, Andrea Winterbottom, Marc Chakiachvili, Ameya Chaubal, Nishadi De Silva, Bethany Flint, Adam Frankish, Sarah E Hunt, Garth R IIsley, Nick Langridge, Jane E Loveland, Fergal J Martin, Jonathan M Mudge, Joanella Morales, Emily Perry, Magali Ruffier, John Tate, David Thybert, Stephen J Trevanion, Fiona Cunningham, Andrew D Yates, Daniel R Zerbino, and Paul Flicek

Subjects
Internet, 0303 health sciences, SARS-CoV-2, AcademicSubjects/SCI00010, 030302 biochemistry & molecular biology, COVID-19, Computational Biology, Molecular Sequence Annotation, Genomics, 03 medical and health sciences, ComputingMethodologies_PATTERNRECOGNITION, Vertebrates, Genetics, Animals, Humans, Database Issue, Databases, Nucleic Acid, Pandemics, 030304 developmental biology
Abstract

The Ensembl project (https://www.ensembl.org) annotates genomes and disseminates genomic data for vertebrate species. We create detailed and comprehensive annotation of gene structures, regulatory elements and variants, and enable comparative genomics by inferring the evolutionary history of genes and genomes. Our integrated genomic data are made available in a variety of ways, including genome browsers, search interfaces, specialist tools such as the Ensembl Variant Effect Predictor, download files and programmatic interfaces. Here, we present recent Ensembl developments including two new website portals. Ensembl Rapid Release (http://rapid.ensembl.org) is designed to provide core tools and services for genomes as soon as possible and has been deployed to support large biodiversity sequencing projects. Our SARS-CoV-2 genome browser (https://covid-19.ensembl.org) integrates our own annotation with publicly available genomic data from numerous sources to facilitate the use of genomics in the international scientific response to the COVID-19 pandemic. We also report on other updates to our annotation resources, tools and services. All Ensembl data and software are freely available without restriction.

Published
2020
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7. Ensembl Genomes 2020—enabling non-vertebrate genomic research

Author

Bruno Contreras-Moreira, Laurent Gil, Uma Maheswari, Erin Haskell, Paul Flicek, Kim E. Hammond-Kosack, Stephen J. Trevanion, Matthieu Barba, Sushma Naithani, Matthew Russell, Mark D. McDowall, Nancy George, Andrew D. Yates, Emily Perry, Vasily Sitnik, Dan Bolser, Michael Paulini, Paul J. Kersey, Pankaj Jaiswal, Mikkel B. Christensen, Helder Pedro, Gareth Maslen, Lahcen Cambell, Sophie Helen Janacek, Daniel M. Staines, Gary Williams, Matthieu Muffato, Carla Cummins, Wasiu Akanni, Marc Rosello, James E. Allen, Irene Papatheodorou, Astrid Gall, Nick Langridge, Marc Chakiachvili, Joshua C. Stein, Mateus Patricio, Silvie Fexova, Nishadi De Silva, Sarah E. Hunt, Benjamin Moore, Martin Urban, Justin Preece, Marcela K. Tello-Ruiz, Guy Naamati, Andrew Olson, Parul Gupta, Thomas Maurel, Jorge Alvarez-Jarreta, Doreen Ware, Paul Davis, Manuel Carbajo, Alayne Cuzick, Kevin L. Howe, and Sharon Wei

Subjects
0106 biological sciences, Tree of life, Genomics, Context (language use), Computational biology, Biology, 01 natural sciences, Genome, User-Computer Interface, 03 medical and health sciences, Resource (project management), Reference Values, Ensembl Genomes, Databases, Genetic, Genetics, Database Issue, Animals, Ensembl, Caenorhabditis elegans, 030304 developmental biology, Internet, 0303 health sciences, Computational Biology, Genetic Variation, Molecular Sequence Annotation, Plants, Phenotype, Genome, Fungal, Algorithms, Genome, Bacterial, Genome, Plant, Software, 010606 plant biology & botany
Abstract

Ensembl Genomes (http://www.ensemblgenomes.org) is an integrating resource for genome-scale data from non-vertebrate species, complementing the resources for vertebrate genomics developed in the context of the Ensembl project (http://www.ensembl.org). Together, the two resources provide a consistent set of interfaces to genomic data across the tree of life, including reference genome sequence, gene models, transcriptional data, genetic variation and comparative analysis. Data may be accessed via our website, online tools platform and programmatic interfaces, with updates made four times per year (in synchrony with Ensembl). Here, we provide an overview of Ensembl Genomes, with a focus on recent developments. These include the continued growth, more robust and reproducible sets of orthologues and paralogues, and enriched views of gene expression and gene function in plants. Finally, we report on our continued deeper integration with the Ensembl project, which forms a key part of our future strategy for dealing with the increasing quantity of available genome-scale data across the tree of life.

Published
2019
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8. Ensembl 2021

Author

Kevin L Howe, Premanand Achuthan, James Allen, Jamie Allen, Jorge Alvarez-Jarreta, M Ridwan Amode, Irina M Armean, Andrey G Azov, Ruth Bennett, Jyothish Bhai, Konstantinos Billis, Sanjay Boddu, Mehrnaz Charkhchi, Carla Cummins, Luca Da Rin Fioretto, Claire Davidson, Kamalkumar Dodiya, Bilal El Houdaigui, Reham Fatima, Astrid Gall, Carlos Garcia Giron, Tiago Grego, Cristina Guijarro-Clarke, Leanne Haggerty, Anmol Hemrom, Thibaut Hourlier, Osagie G Izuogu, Thomas Juettemann, Vinay Kaikala, Mike Kay, Ilias Lavidas, Tuan Le, Diana Lemos, Jose Gonzalez Martinez, José Carlos Marugán, Thomas Maurel, Aoife C McMahon, Shamika Mohanan, Benjamin Moore, Matthieu Muffato, Denye N Oheh, Dimitrios Paraschas, Anne Parker, Andrew Parton, Irina Prosovetskaia, Manoj P Sakthivel, Ahamed I Abdul Salam, Bianca M Schmitt, Helen Schuilenburg, Dan Sheppard, Emily Steed, Michal Szpak, Marek Szuba, Kieron Taylor, Anja Thormann, Glen Threadgold, Brandon Walts, Andrea Winterbottom, Marc Chakiachvili, Ameya Chaubal, Nishadi De Silva, Bethany Flint, Adam Frankish, Sarah E Hunt, Garth R IIsley, Nick Langridge, Jane E Loveland, Fergal J Martin, Jonathan M Mudge, Joanella Morales, Emily Perry, Magali Ruffier, John Tate, David Thybert, Stephen J Trevanion, Fiona Cunningham, Andrew D Yates, Daniel R Zerbino, Paul Flicek.

Abstract

The Ensembl project (https://www.ensembl.org) annotates genomes and disseminates genomic data for vertebrate species. We create detailed and comprehensive annotation of gene structures, regulatory elements and variants, and enable comparative genomics by inferring the evolutionary history of genes and genomes. Our integrated genomic data are made available in a variety of ways, including genome browsers, search interfaces, specialist tools such as the Ensembl Variant Effect Predictor, download files and programmatic interfaces. Here, we present recent Ensembl developments including two new website portals. Ensembl Rapid Release (http://rapid.ensembl.org) is designed to provide core tools and services for genomes as soon as possible and has been deployed to support large biodiversity sequencing projects. Our SARS-CoV-2 genome browser (https://covid-19.ensembl.org) integrates our own annotation with publicly available genomic data from numerous sources to facilitate the use of genomics in the international scientific response to the COVID-19 pandemic. We also report on other updates to our annotation resources, tools and services. All Ensembl data and software are freely available without restriction.

Published
2020

9. Ensembl 2019

Author

Fiona Cunningham, Premanand Achuthan, Wasiu Akanni, James Allen, M Ridwan Amode, Irina M Armean, Ruth Bennett, Jyothish Bhai, Konstantinos Billis, Sanjay Boddu, Carla Cummins, Claire Davidson, Kamalkumar Jayantilal Dodiya, Astrid Gall, Carlos García Girón, Laurent Gil, Tiago Grego, Leanne Haggerty, Erin Haskell, Thibaut Hourlier, Osagie G Izuogu, Sophie H Janacek, Thomas Juettemann, Mike Kay, Matthew R Laird, Ilias Lavidas, Zhicheng Liu, Jane E Loveland, José C Marugán, Thomas Maurel, Aoife C McMahon, Benjamin Moore, Joannella Morales, Jonathan M Mudge, Michael Nuhn, Denye Ogeh, Anne Parker, Andrew Parton, Mateus Patricio, Ahamed Imran Abdul Salam, Bianca M Schmitt, Helen Schuilenburg, Dan Sheppard, Helen Sparrow, Eloise Stapleton, Marek Szuba, Kieron Taylor, Glen Threadgold, Anja Thormann, Alessandro Vullo, Brandon Walts, Andrea Winterbottom, Amonida Zadissa, Marc Chakiachvili, Adam Frankish, Sarah E Hunt, Myrto Kostadima, Nick Langridge, Fergal J Martin, Matthieu Muffato, Emily Perry, Magali Ruffier, Daniel M Staines, Stephen J Trevanion, Bronwen L Aken, Andrew D Yates, Daniel R Zerbino, and Paul Flicek

Subjects
0301 basic medicine, Genome, Computational Biology, Molecular Sequence Annotation, Genomics, 03 medical and health sciences, Mice, 030104 developmental biology, 0302 clinical medicine, ComputingMethodologies_PATTERNRECOGNITION, Databases, Genetic, Vertebrates, Genetics, Database Issue, Animals, Humans, 030217 neurology & neurosurgery, Software
Abstract

The Ensembl project (https://www.ensembl.org) makes key genomic data sets available to the entire scientific community without restrictions. Ensembl seeks to be a fundamental resource driving scientific progress by creating, maintaining and updating reference genome annotation and comparative genomics resources. This year we describe our new and expanded gene, variant and comparative annotation capabilities, which led to a 50% increase in the number of vertebrate genomes we support. We have also doubled the number of available human variants and added regulatory regions for many mouse cell types and developmental stages. Our data sets and tools are available via the Ensembl website as well as a through a RESTful webservice, Perl application programming interface and as data files for download.

Published
2018

10. Ensembl Genomes 2022: an expanding genome resource for non-vertebrates

Author

Andrew D. Yates, Michael Paulini, Anne Parker, Kim E. Hammond-Kosack, Marcela K. Tello-Ruiz, Justin Elser, Jyothish Bhai, Manuel Luypaert, Faye H. Rodgers, Stavros Diamantakis, James Seager, Pankaj Jaiswal, Robert D. Finn, Thomas Maurel, Michal Szpak, Marc Rosello, James E. Allen, Parul Gupta, Matthieu Barba, Lahcen I. Campbell, Marc Chakiachvili, Vivek Kumar, Manuel Carbajo Martinez, Benjamin Moore, Nishadi De Silva, John Tate, Ridwan M Amode, Andrew Olson, Astrid Gall, Magali Ruffier, Paul Davis, Mikkel B. Christensen, Mark Quinton-Tulloch, Alayne Cuzick, Kevin L. Howe, Martin Urban, Justin Preece, Nick Langridge, Sunita Kumari, Kapeel Chougule, Emily Perry, Tuan Le, Gareth Maslen, Sharon Wei, Dionysios Grigoriadis, Carla Valeria Filippi, Andrea Winterbottom, Doreen Ware, Aleena Mushtaq, Vinay Kaikala, Andrey G Azov, Helder Pedro, Luca Da Rin Fioretto, Gary Williams, Magdalena Zarowiecki, Cristina Guijarro-Clarke, Guy Naamati, Sushma Naithani, Bruno Contreras-Moreira, Sarah Dyer, Andrés Becerra, Paul Flicek, Matthieu Muffato, Vasily Sitnik, and Stephen J. Trevanion

Subjects
Whole genome sequencing, Internet, AcademicSubjects/SCI00010, Computational Biology, Genomics, Genome project, Gene Annotation, Computational biology, Plants, Biology, Genome, Annotation, Resource (project management), ComputingMethodologies_PATTERNRECOGNITION, Ensembl Genomes, Databases, Genetic, Vertebrates, Genetics, Database Issue, Animals, Ensembl, Genome, Fungal, Genome, Bacterial, Genome, Plant, Software
Abstract

Ensembl Genomes (https://www.ensemblgenomes.org) provides access to non-vertebrate genomes and analysis complementing vertebrate resources developed by the Ensembl project (https://www.ensembl.org). The two resources collectively present genome annotation through a consistent set of interfaces spanning the tree of life presenting genome sequence, annotation, variation, transcriptomic data and comparative analysis. Here, we present our largest increase in plant, metazoan and fungal genomes since the project's inception creating one of the world's most comprehensive genomic resources and describe our efforts to reduce genome redundancy in our Bacteria portal. We detail our new efforts in gene annotation, our emerging support for pangenome analysis, our efforts to accelerate data dissemination through the Ensembl Rapid Release resource and our new AlphaFold visualization. Finally, we present details of our future plans including updates on our integration with Ensembl, and how we plan to improve our support for the microbial research community. Software and data are made available without restriction via our website, online tools platform and programmatic interfaces (available under an Apache 2.0 license). Data updates are synchronised with Ensembl's release cycle.

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