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2. Calcium metabolism and vitamin D in the extreme longevity

Author

Passeri, G, Vescovini, R, Sansoni, P, Galli, C, Franceschi, C, Passeri, M, Italian Multicentric Study on Centenarians 87 Collaborators, Motta, M, Motta, L, Capurso, A, Panza, F, Solfrizzi, V, D'Introno, A, Colacicco, Am, Capurso, S, Capri, M, Salvioli, S, Valensin, S, Bennati, E, Malaguarnera, M, Maugeri, D, Rapisarda, R, Franzone, A, Ferlito, L, De Benedictis, G, Berardelli, M, Masotti, G, Petruzzi, E, Petruzzi, I, Pinzani, P, Monti, D, Antonini, Fm, Capurso, C, Nicita Mauro, V, Lo Balbo, C, Mento, A, Nicita Mauro, C, Maltese, G, Basile, G, Mari, D, Coppola, R, Provenzano, R, Salvioli, G, Baldelli, Mv, Mussi, C, Varricchio, M, Barbieri, M, Gambardella, A, Paolisso, G, Caruso, C, Candore, G, Colonna Romano, G, Lio, D, Biasini, C, Telera, A, Ferrari, E, Cravello, L, Barili, L, Solerte, Sb, Fioravanti, M, Magri, F, Fagnoni, F, Senin, Umberto, Mecocci, Patrizia, Cherubini, Antonio, Marigliano, V, Tafaro, L, Cicconetti, P, Tombesi, F, Tombolillo, Mt, Ettore, E, Forconi, S, Boschi, S, Righi, Ga, Guerrini, M, Giarelli, L, Stanta, G, Ferrucci, L, Ble, A, Metter, Ej, Guralnik, Jm, Pacifici, R, Zuccaro, P, Palmi, I, Branca, S, Fradà, G, Motta, F, Crimi, G., Passeri, G, Vescovini, R, Sansoni, P, Galli, C, Franceschi, C, Passeri, M, Paolisso, G, Barbieri, M, Italian Multicentric Study on Centenarians, (IMUSCE)., Passeri G., Vescovini R., Sansoni P., Galli C., Franceschi C., Passeri M., Italian Multicentric Study on Centenarians (IMUSCE), Motta M., Motta L., Capurso A., Panza F., Solfrizzi V., D'Introno A., Colacicco A.M., Capurso S., Capri M., Salvioli S., Valensin S., Bennati E., Malaguarnera M., Maugeri D., Rapisarda R., Franzone A., Ferlito L., De Benedictis G., Berardelli M., Masotti G., Petruzzi E., Petruzzi I., Pinzani P., Monti D., Antonini F.M., Capurso C., Nicita-Mauro V., Lo Balbo C., Mento A., Nicita-Mauro C., Maltese G., Basile G., Mari D., Coppola R., Provenzano R., Salvioli G., Baldelli M.V., Mussi C., Varricchio M., Barbieri M., Gambardella A., Paolisso G., Caruso C., Candore G., Colonna-Romano G., Lio D., Biasini C., Telera A., Ferrari E., Cravello L., Barili L., Solerte S.B., Fioravanti M., Magri F., Fagnoni F., Senin U., Mecocci P., Cherubini A., Marigliano V., Tafaro L., Cicconetti P., Tombesi F., Tombolillo M.T., Ettore E., Forconi S., Boschi S., Righi G.A., Guerrini M., Giarelli L., Stanta G., Ferrucci L., Ble A., Metter E.J., Guralnik J.M., Pacifici R., Zuccaro P., Palmi I., Branca S., Fradà G., Motta F., Crimi G., Dipartimento di Medicina Interna e Scienze Biomediche, University of Parma = Università degli studi di Parma [Parme, Italie], Dipartimento di Patologia Sperimentale, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Motta, M, Motta, L, Capurso, A, Panza, F, Solfrizzi, V, D'Introno, A, Colacicco, Am, Capurso, S, Capri, M, Salvioli, S, Valensin, S, Bennati, E, Malaguarnera, M, Maugeri, D, Rapisarda, R, Franzone, A, Ferlito, L, De Benedictis, G, Berardelli, M, Masotti, G, Petruzzi, E, Petruzzi, I, Pinzani, P, Monti, D, Antonini, Fm, Capurso, C, Nicita Mauro, V, Lo Balbo, C, Mento, A, Nicita Mauro, C, Maltese, G, Basile, G, Mari, D, Coppola, R, Provenzano, R, Salvioli, G, Baldelli, Mv, Mussi, C, Varricchio, M, Gambardella, A, Caruso, C, Candore, G, Colonna Romano, G, Lio, D, Biasini, C, Telera, A, Ferrari, E, Cravello, L, Barili, L, Solerte, Sb, Fioravanti, M, Magri, F, Fagnoni, F, Senin, U, Mecocci, P, Cherubini, A, Marigliano, V, Tafaro, L, Cicconetti, P, Tombesi, F, Tombolillo, Mt, Ettore, E, Forconi, S, Boschi, S, Righi, Ga, Guerrini, M, Giarelli, L, Stanta, Giorgio, Ferrucci, L, Ble, A, Metter, Ej, Guralnik, Jm, Pacifici, R, Zuccaro, P, Palmi, I, Branca, S, Fradà, G, Motta, F, and Crimi, G.

Subjects
Male, Aging, Bone density, Osteoporosis, Parathyroid hormone, Vitamin D, Calcium metabolism, Extreme longevity, Bone fractures, Self-sufficiency, Biochemistry, Bone remodeling, 0302 clinical medicine, Endocrinology, Bone Density, calcium metabolism, vitamin D, longevity, ComputingMilieux_MISCELLANEOUS, Aged, 80 and over, 0303 health sciences, 3. Good health, Parathyroid Hormone, 030220 oncology & carcinogenesis, Medicine, Female, Risk, medicine.medical_specialty, Longevity, Bone resorption, vitamin D deficiency, Article, 03 medical and health sciences, N-terminal telopeptide, Internal medicine, Genetics, medicine, Vitamin D and neurology, Humans, Bone Resorption, Molecular Biology, 030304 developmental biology, business.industry, Cell Biology, medicine.disease, Vitamin D Deficiency, Diet, Calcium, business
Abstract

Skeletal remodelling is a continuous process during life and is still active also in extreme senescence. In the elderly, bone resorption often prevails over bone formation, causing bone loss and fragility. Elderly subjects are exposed to the risk of fractures, and loss of self-sufficiency, if considering that the proximal femur is the most frequently involved site. Bone remodelling can maintain circulating calcium within physiological ranges, at the expense of a substantial loss of this ion from the skeleton, particularly during senescence. Calcium metabolism is regulated at cellular/molecular level by a network of cytokines, growth factors, systemic hormones that act on bone in paracrine/autocrine/systemic fashion. Among the molecules involved in bone metabolism, parathyroid hormone (PTH) and vitamin D present some peculiar aspects during senescence. The osteometabolic features in a consistent group of centenarians have been evaluated. It results that a severe hypovitaminosis D was present in 99 out of 104 centenarians (25-OH vitamin D below 5 nmol/L), and that it plays an important role as a factor inducing a vicious circle involving hypocalcemia, secondary hyperparathyroidism, together with biochemical features indicating a consistent bone loss. Serum C-terminal cross-linking telopeptide, a specific marker of bone resorption was elevated in 92% of these subjects. Moreover, it has been found that several femoral fractures had occurred after 90 years of age. These data offer a rational for the possible prevention of elevated bone turnover, bone loss and consequently the reduction of osteoporotic fractures and fractures-induced disability, in the oldest olds, through the simple supplementation with calcium and vitamin D.

Published
2007
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3. Health care for older people in Italy: The U.L.I.S.S.E. Project (Un link informatico sui servizi sanitari esistenti per l'anziano - a computerized network on health care services for older people)

Author

Lattanzio F, Mussi C, Scafato E, Ruggiero C, Dell'Aquila G, Pedone C, Mammarella F, Galluzzo L, Salvioli G, Senin U, Carbonin PU, Bernabei R, Cherubini A, Laguzzi E, Cucinotta D, Arnone G, Rozzini R, Cassinadri A, Putzu P, Porceddu C, Zaru C, Abate G, Di Iorio A, Abate M, Guglielmi M, Foschini N, Battaglini C, Fellin R, Volpato S, Cavalieri M, Fotini S, Guerra G, Rossi L, Masotti G, Fumagalli S, Odetti P, Cataldi A, Monacelli F, Nicita Mauro V, Basile G, Maltese G, Nicita Mauro C, Pellicciotti F, Scotto R, Vaccina A, Minnucci A, Forte L, Lo Storoto MR, Licata G, Tuttolomondo A, Barbagallo M, Dominguez LJ, De Leo M, Belvedere M, Putignano E, Longo A, Mancioli G, Patacchini F, Palmari N, Ierardi BA, Marino P, Soldato M, Pilotto A, Paris F, Forconi S, Guerrini M, De Paduanis GA, De Palma A, Boschi S, Molaschi M, Poli L, De Colle P, Bonoldi G, Puricelli S, Pellegrini R, Consolaro E, Bosello O, Zivelonghi A, Gravic G, Guariento S, Di Francesco V, Tua E, Pisaturo A, Lacava R, Gareri P, Borgia R, Cristiano VN, Palummeri, Pescetelli, Galdi M, Bochicchio GB, Solimano A, Brugaletta S, Carnazza L, Gallitto E, Albano G, Schipani G, Conte, Pagella A, Perrero L, Sabato V, Marella L, Schiavina, Zacco B, Scaglia L, Virgilio A, Iera M, Doria, Pansini L, Boni N, Inzitari M, Aramini I, Musante S, Cavagnaro P, Riello F, De Alfieri W, Pescetelli P, Trecca R, Di Iusto, Zamboni V, Cuppone R, Foschi, Marino S, Simone M, Scarlata A, Battegazzore C, Morucci R, Luchetti M, Menculini G, Cichetti G, Orlando I, Fantoni B, Ognibene G, Gobbi C, Cascone A, Avanzi GL, Casu A, Zeni S, Santin S, Scotti G, Cappella C, Penzo P., TOIGO, GABRIELE, Lattanzio, F, Mussi, C, Scafato, E, Ruggiero, C, Dell'Aquila, G, Pedone, C, Mammarella, F, Galluzzo, L, Salvioli, G, Senin, U, Carbonin, Pu, Bernabei, R, Cherubini, A, Laguzzi, E, Cucinotta, D, Arnone, G, Rozzini, R, Cassinadri, A, Putzu, P, Porceddu, C, Zaru, C, Abate, G, Di Iorio, A, Abate, M, Guglielmi, M, Foschini, N, Battaglini, C, Fellin, R, Volpato, S, Cavalieri, M, Fotini, S, Guerra, G, Rossi, L, Masotti, G, Fumagalli, S, Odetti, P, Cataldi, A, Monacelli, F, Nicita Mauro, V, Basile, G, Maltese, G, Nicita Mauro, C, Pellicciotti, F, Scotto, R, Vaccina, A, Minnucci, A, Forte, L, Lo Storoto, Mr, Licata, G, Tuttolomondo, A, Barbagallo, M, Dominguez, Lj, De Leo, M, Belvedere, M, Putignano, E, Longo, A, Mancioli, G, Patacchini, F, Palmari, N, Ierardi, Ba, Marino, P, Soldato, M, Pilotto, A, Paris, F, Forconi, S, Guerrini, M, De Paduanis, Ga, De Palma, A, Boschi, S, Molaschi, M, Poli, L, Toigo, Gabriele, De Colle, P, Bonoldi, G, Puricelli, S, Pellegrini, R, Consolaro, E, Bosello, O, Zivelonghi, A, Gravic, G, Guariento, S, Di Francesco, V, Tua, E, Pisaturo, A, Lacava, R, Gareri, P, Borgia, R, Cristiano, Vn, Palummeri, Pescetelli, Galdi, M, Bochicchio, Gb, Solimano, A, Brugaletta, S, Carnazza, L, Gallitto, E, Albano, G, Schipani, G, Conte, Pagella, A, Perrero, L, Sabato, V, Marella, L, Schiavina, Zacco, B, Scaglia, L, Virgilio, A, Iera, M, Doria, Pansini, L, Boni, N, Inzitari, M, Aramini, I, Musante, S, Cavagnaro, P, Riello, F, De Alfieri, W, Pescetelli, P, Trecca, R, Di, Iusto, Zamboni, V, Cuppone, R, Foschi, Marino, S, Simone, M, Scarlata, A, Battegazzore, C, Morucci, R, Luchetti, M, Menculini, G, Cichetti, G, Orlando, I, Fantoni, B, Ognibene, G, Gobbi, C, Cascone, A, Avanzi, Gl, Casu, A, Zeni, S, Santin, S, Scotti, G, Cappella, C, and Penzo, P.

Subjects
computerized network, Health care, service, elderly
Abstract

Objectives: The U.L.I.S.S.E. study is aimed at describing older patients who are cared for in hospitals, home care or nursing homes in Italy. Design: The U.L.I.S.S.E. study is an observational multicenter prospective 1-year study. Setting: Overall, 23 acute geriatric or internal medicine hospital units, 11 home care services and 31 nursing homes participated in the study. Measurements: The patient’s evaluation was performed using comprehensive geriatric assessment instruments, i.e. the interRAI Minimum Data Set, while data on service characteristics were recorded using ad-hoc designed questionnaires. Results: The older subjects who are in need of acute and long term care in Italy have similar characteristics: their mean age is higher than 80 years, they have a high level of disability in ADL, an important multimorbidity, and are treated with several drugs. The prevalence of cognitive impairment is particularly high in nursing homes, where almost 70% of residents suffer from it and 40% have severe cognitive impairment. On the other hand, there is a shortage of health care services, which are heterogeneous and fragmented. Conclusions: Health care services for older people in Italy are currently inadequate to manage the complexity of the older patients. An important effort should be undertaken to create a more integrated health care system.

Published
2010

4. The extreme longevity: the state of the art in Italy

Author

FRANCESCHI, CLAUDIO, CAPRI, MIRIAM, SALVIOLI, STEFANO, VALENSIN, SILVANA, Motta L., Motta M., Malaguarnera M., Vasto S., Candore G., Caruso C., Capurso A., Panza F., Solfrizzi V., D'Introno A., Colacicco A. M., Capurso S., Bennati E., Maugeri D., Rapisarda R., Franzone A., Ferlito L., De Benedictis G., Berardelli M., Masotti G., Petruzzi E., Petruzzi I., Pinzani P., Monti D., Antonini F. M., Capurso C., Nicita Mauro V., Lo Balbo C., Mento A., Nicita Mauro C., Maltese G., Basile G., Mari D., Coppola R., Provenzano R., Salvioli G., Baldelli M. V., Mussi C., Varricchio M., Barbieri M., Gambardella A., Paolisso G., Colonna Romano G., Lio D., Sansoni P., Vescovini R., Galli C., Biasini C., Telera A., Passeri G., Passeri M., Ferrari E., Cravello L., Barili L., Solerte S. B., Fioravanti M., Magri F., Fagnoni F., Senin U., Mecocci P., Cherubini A., Marigliano V., Tafaro L., Cicconetti P., Tombesi F., Tombolillo M. T., Ettore E., Forconi S., Boschi S., Righi G. A., Guerrini M., Giarelli L., Stanta G., Ferrucci L., Ble A., Metter E. J., Guralnik J. M., Pacifici R., Zuccaro P., Palmi I., Branca S., Fradà G., Motta F., Crimi G., FRANCESCHI C, MOTTA L, MOTTA M, MALAGUARNERA M, CAPRI M, VASTO S, CANDORE G, CARUSO C, IMUSCE, Franceschi C., Motta L., Motta M., Malaguarnera M., Capri M., Vasto S., Candore G., Caruso C., Capurso A., Panza F., Solfrizzi V., D'Introno A., Colacicco A.M., Capurso S., Salvioli S., Valensin S., Bennati E., Maugeri D., Rapisarda R., Franzone A., Ferlito L., De Benedictis G., Berardelli M., Masotti G., Petruzzi E., Petruzzi I., Pinzani P., Monti D., Antonini F.M., Capurso C., Nicita-Mauro V., Lo Balbo C., Mento A., Nicita-Mauro C., Maltese G., Basile G., Mari D., Coppola R., Provenzano R., Salvioli G., Baldelli M.V., Mussi C., Varricchio M., Barbieri M., Gambardella A., Paolisso G., Colonna-Romano G., Lio D., Sansoni P., Vescovini R., Galli C., Biasini C., Telera A., Passeri G., Passeri M., Ferrari E., Cravello L., Barili L., Solerte S.B., Fioravanti M., Magri F., Fagnoni F., Senin U., Mecocci P., Cherubini A., Marigliano V., Tafaro L., Cicconetti P., Tombesi F., Tombolillo M.T., Ettore E., Forconi S., Boschi S., Righi G.A., Guerrini M., Giarelli L., Stanta G., Ferrucci L., Ble A., Metter E.J., Guralnik J.M., Pacifici R., Zuccaro P., Palmi I., Branca S., Fradà G., Motta F., and Crimi G.

Subjects
Gerontology, Male, Aging, media_common.quotation_subject, Health Status, Longevity, Biochemistry, Endocrinology, State (polity), Development economics, Genetics, Diabetes Mellitus, Medicine, Humans, Molecular Biology, media_common, Aged, 80 and over, business.industry, Cell Biology, Gene Expression Regulation, Italy, Cardiovascular Diseases, Immune System, Extreme longevity tracking, Female, business
Published
2008

6. Health care for older people in Italy: The U.L.I.S.S.E. Project (Un link informatico sui servizi sanitari esistenti per l'anziano - a computerized network on health care services for older people)

Author

Lattanzio, F, Mussi, C, Scafato, E, Ruggiero, C, Dell'Aquila, G, Pedone, C, Mammarella, F, Galluzzo, L, Salvioli, G, Senin, U, Carbonin, Pu, Bernabei, R, Cherubini, A, STUDY GROUP LAGUZZI E, U. L. I. S. S. E., Cucinotta, D, Arnone, G, Rozzini, R, Cassinadri, A, Putzu, P, Porceddu, C, Zaru, C, Abate, G, DI IORIO, A, Abate, M, Guglielmi, M, Foschini, N, Battaglini, C, Fellin, R, Volpato, S, Cavalieri, M, Fotini, S, Guerra, G, Rossi, L, Masotti, G, Fumagalli, S, Odetti, Patrizio, Cataldi, A, Monacelli, Fiammetta, NICITA MAURO, V, Basile, G, Maltese, G, NICITA MAURO, C, Pellicciotti, F, Scotto, R, Vaccina, A, Minnucci, A, Forte, L, LO STOROTO MR, Licata, G, Tuttolomondo, A, Barbagallo, M, Dominguez, Lj, DE LEO, M, Belvedere, M, Putignano, E, Longo, A, Mancioli, G, Patacchini, F, Palmari, N, Ierardi, Ba, Marino, P, Soldato, M, Pilotto, A, Paris, F, Forconi, S, Guerrini, M, DE PADUANIS GA, DE PALMA, A, Boschi, S, Molaschi, M, Poli, L, Toigo, G, DE COLLE, P, Bonoldi, G, Puricelli, S, Pellegrini, R, Consolaro, E, Bosello, O, Zivelonghi, A, Gravic, G, Guariento, S, DI FRANCESCO, V, Tua, E, Pisaturo, A, Lacava, R, Gareri, P, Borgia, R, Cristiano, Vn, Palummeri, Pescetelli, Galdi, M, Bochicchio, Gb, Solimano, A, Brugaletta, S, Carnazza, L, Gallitto, E, Albano, G, Schipani, G, Conte, Pagella, A, Perrero, L, Sabato, V, Marella, L, Schiavina, Zacco, B, Scaglia, L, Virgilio, A, Iera, M, Doria, Pansini, L, Boni, N, Inzitari, M, Aramini, I, Musante, S, Cavagnaro, P, Riello, F, DE ALFIERI, W, Pescetelli, P, Trecca, R, Iusto, Di, Zamboni, V, Cuppone, R, Foschi, Marino, S, Simone, M, Scarlata, A, Battegazzore, C, Morucci, R, Luchetti, M, Menculini, G, Cichetti, G, Orlando, I, Fantoni, B, Ognibene, G, Gobbi, C, Cascone, A, Avanzi, Gl, Casu, A, Zeni, S, Santin, S, Scotti, G, Cappella, C, and Penzo, P.

Subjects
residenzialità, non autosufficienza, cura anziani, servizio sanitario
Published
2010

10. Vascular aging and geriatric patient

Author

NICITA MAURO, Vittorio, Maltese, G, NICITA MAURO, C, and Basile, Giorgio

Subjects
Aging, Arteries, Oxidative Stress, Life Expectancy, Patient Education as Topic, Cardiovascular Diseases, Geriatrics, Risk Factors, Workforce, Humans, Endothelium, Vascular, Geriatric Assessment, Life Style, Aged
Abstract

Advancing age is associated with changes in structure and function of different segments of the vascular system and is the dominant risk factor for cardiovascular diseases. The oxidative stress represents a key event of vascular aging, mainly characterized by endothelium dysfunction and reduced arterial elasticity. Age-related changes include intimal and medial thickening, arterial calcification, increased deposition of matrix substances, thus leading to a reduced compliance and increased wall stiffness, that significantly contributes to an increase in systolic blood pressure. Frail elderly patients, because of their complex clinical presentations and needs, require a special approach: the comprehensive geriatric assessment, a multidimensional process intended to determine medical, psychosocial and functional capabilities and problems in order to develop a plan for treatment and continued care. All physicians, and geriatricians in particular, must, therefore, educate their patients to healthy lifestyle to prevent or delay vascular aging, cardiovascular diseases, and to maintain a good quality of life and increase life expectancy.

Published
2007

15. Il tabagismo nella donna

Author

NICITA MAURO, Vittorio, Maltese, G, Mento, A, NICITA MAURO, C, and Basile, Giorgio

Published
2005

21. Genetic aspects of bronchial asthma

Author

PURELLO DAMBROSIO, F., Gangemi, Sebastiano, Barresi, L., NICITA MAURO, C., Merendino, R. A., Ricciardi, Luisa, Isola, S., and SALPIETRO DAMIANO, Carmelo

Published
1999

22. ASPETTI GENETICI DELL'ASMA BRONCHIALE

Author

PURELLO DAMBROSIO, F., Gangemi, Sebastiano, Barresi, L., NICITA MAURO, C., Merendino, Rosaria, Ricciardi, M. L., Isola, S., and SALPIETRO DAMIANO, Carmelo

Published
1999

27. Smoking, health and ageing

Author

Calogero Caruso, Giuseppe Maltese, Sebastiano Gangemi, Vittorio Nicita-Mauro, Giorgio Basile, C. Nicita-Mauro, NICITA-MAURO, V, BASILE, G, MALTESE, G, NICITA-MAURO, C, GANGEMI, S, and CARUSO, C

Subjects
Settore MED/04 - Patologia Generale, Gerontology, lcsh:Immunologic diseases. Allergy, Aging, medicine.medical_specialty, Geriatrics gerontology, business.industry, media_common.quotation_subject, Nicotine patch, medicine.medical_treatment, Public health, Immunology, Longevity, Short Report, lcsh:Geriatrics, Nicotine replacement therapy, Ageing, lcsh:RC952-954.6, Medicine, Smoking, health, ageing, Risk factor, business, lcsh:RC581-607, media_common
Abstract

On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related diseases was held in Palermo, Italy. Here, the lecture of V. Nicita-Mauro on Smoking, health and ageing is summarized. Smoking represents an important ageing accelerator, both directly by triggering ana inflammatory responses, and indirectly by favoring the occurrence of several diseases where smoking is a recognized risk factor. Hence, non-smokers can delay the appearance of diseases and of ageing process, so attaining longevity.

Published
2008

28. Smoking, health and ageing.

Author

Nicita-Mauro V, Basile G, Maltese G, Nicita-Mauro C, Gangemi S, and Caruso C

Abstract

On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related diseases was held in Palermo, Italy. Here, the lecture of V. Nicita-Mauro on Smoking, health and ageing is summarized. Smoking represents an important ageing accelerator, both directly by triggering an inflammatory responses, and indirectly by favoring the occurrence of several diseases where smoking is a recognized risk factor. Hence, non-smokers can delay the appearance of diseases and of ageing process, so attaining longevity.

Published
2008
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29. Correlation between serum retinol and alpha-tocopherol levels in centenarians.

Author

Basile G, Gangemi S, Lo Balbo C, Mento A, Nicita-Mauro C, Crisafulli G, Merendino RA, Ientile R, and Nicita-Mauro V

Subjects
Aged, Aged, 80 and over, Aging physiology, Case-Control Studies, Female, Humans, Male, Oxidative Stress, Aging blood, Antioxidants metabolism, Longevity, Vitamin A blood, alpha-Tocopherol blood
Abstract

Recent evidence indicates that longevity may be achieved when efficient defence mechanisms against oxidative stress, infections, neoplasia, and cardiovascular events are preserved. Centenarians represent an example of "successful aging," and the aim of this study was to evaluate serum levels of vitamins A and E, which represent two important nonenzymatic antioxidant defence systems, and their correlation in 16 healthy centenarians and two groups of control subjects. Centenarians showed normal values of retinol (450.9 +/- 240.3 ng/mL) and alpha-tocopherol (9220.2 +/- 3410.9 ng/mL). Moreover, a significant direct correlation between the two vitamins was observed in centenarians (Rho = 0.715, p = 0.0056), such as in younger control subjects (Rho = 0.618, p = 0.0168), but not in older control subjects. We assume that the preservation of normal values and the correlation between vitamin A and E concentrations protects centenarians against oxidative stress and contributes to their extreme longevity.

Published
2003
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