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Your search keyword '"Nichols, Ellen"' showing total 14 results
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14 results on '"Nichols, Ellen"'

1. A Phase 1/2 Study to Evaluate the Safety and Activity of Nivolumab in Combination With Vorolanib, a Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor, in Patients With Refractory Thoracic Tumors

Author

Beckermann, Kathryn E., Bestvina, Christine M., El Osta, Badi, Sanborn, Rachel E., Borghaei, Hossein, Lammers, Philip Edward, Selvaggi, Giovanni, Whisenant, Jennifer G., Heimann-Nichols, Ellen, Berry, Lynne, Hsu, Chih-Yuan, Shyr, Yu, Horn, Leora, and Wakelee, Heather

Published
2024
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4. Identification of calcium-modulating cyclophilin ligand as a human host restriction to HIV-1 release overcome by Vpu

Author

Varthakavi, Vasundhara, Heimann-Nichols, Ellen, Smith, Rita M., Sun, Yuehui, Bram, Richard J., Ali, Showkat, Rose, Jeremy, Ding, Lingmei, and Spearman, Paul

Subjects
Drug therapy, Genetic aspects, Research, Health aspects, HIV infections -- Genetic aspects -- Drug therapy -- Research, Cyclophilin -- Research -- Genetic aspects -- Health aspects, Membrane proteins -- Health aspects -- Genetic aspects -- Research, HIV infection -- Genetic aspects -- Drug therapy -- Research
Abstract

Vpu is an oligomeric type 1 integral membrane protein that has two distinct and separable functions in HIV replication (1,2). Vpu interacts with CD4 and the host factor human β-transducin [...], The HIV-1 Vpu protein is required for efficient viral release from human cells. For HIV-2, the envelope (Env) protein replaces the role of Vpu. Both Vpu and HIV-2 Env enhance virus release by counteracting an innate host-cell block within human cells that is absent in African green monkey (AGM) cells. Here we identify calcium-modulating cyclophilin ligand (CAML) as a Vpu-interacting host factor that restricts HIV-1 release. Expression of human CAML (encoded by CAMLG) in AGM cells conferred a strong restriction of virus release that was reversed by Vpu and HIV-2 Env, suggesting that CAML is the mechanistic link between these two viral regulators. Depletion of CAML in human cells eliminated the need for Vpu in enhancing HIV-1 and murine leukemia virus release. These results point to CAML as a Vpu-sensitive host restriction factor that inhibits HIV release from human cells. The ability of CAML to inhibit virus release should illuminate new therapeutic strategies against HIV.

Published
2008

6. Communications to engage light-speed leaders

Author

Nichols, Ellen

Subjects
Middle managers -- Research, Organizational communication -- Management, Company business management, Business, Human resources and labor relations
Published
2009

7. Getting the attention of attention-challenged leaders

Author

Nichols, Ellen

Subjects
Managers -- Management, Decision-making -- Management, Organizational behavior -- Research, Company business management, Business, Human resources and labor relations
Abstract

A description of what managers in an organization need to understand when they have to get an executive's attention for gaining input, making decisions or getting directions. Fast and focused communication help attention challenged leader to stay focused and strategic for longer time to trade or receive relevant information.

Published
2008

8. Biometrics: Theory, Applications, and Issues

Author

Nichols, Ellen R. and Nichols, Ellen R.

Subjects
Human face recognition (Computer science), Biometric identification, Biometry
Abstract

In recent years, numerous research papers have considered the problem of privacy protection in biometric authentication systems. When someone wants to authenticate himself, the fresh biometric data he presents has to match with the reference related to the one he claims to be. Many proposals have been made to ensure the confidentiality of the biometric data involved during this verification. Also discussed in this compilation, is the problem of finding a face recognition system that works well both under variable illumination conditions and under strictly controlled acquisition conditions. Information fusion techniques are also explored and have been widely developed in the community of voice biometrics along with several uni-modal speaker recognition algorithms.

Published
2011

11. Murine Norovirus 1 Infection Is Associated with Histopathological Changes in Immunocompetent Hosts, but Clinical Disease Is Prevented by STAT1-Dependent Interferon Responses

Author

Mumphrey, Shannon M., primary, Changotra, Harish, additional, Moore, Tara N., additional, Heimann-Nichols, Ellen R., additional, Wobus, Christiane E., additional, Reilly, Michael J., additional, Moghadamfalahi, Mana, additional, Shukla, Deepti, additional, and Karst, Stephanie M., additional

Published
2007
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12. Hyper-Speed Managers.

Author

Nichols, Ellen

Subjects
EXECUTIVES, BUSINESS meetings, TIME, ATTENTION, CONFERENCE rooms, GOAL (Psychology), PHYSICAL fitness
Abstract

The article offers tips useful in meetings or presentations with hyper-speed managers when time and attention are limited. The author suggests using the conference room during meeting because it is a more controllable environment. She states that it is important to articulate goals accordingly because hyper-speed leaders are looking for results. The author also suggests physical exercise because it slows down the brain which is an opportunity to get focused.

Published
2007

13. liftlines.

Author

McCabe, Jory, Lamson, Alan, Lamson, Michelle, Bartlett, Sophie, Campuzano, Jennifer, Stanwood, Randall, Rhodes, Turner, Brennen, Ann, Connolly, Mark, Glover, Robert L., Harkins, Jeff, Nussbaum, Wendy, Nichols, Ellen, and Pierson, Craig

Subjects
LETTERS to the editor, RESORTS
Abstract

Presents letters to the editor referencing articles and topics discussed in previous issues of the periodical "Ski," including the article "Timeless Turns," which featured a resort in Portillo, Chile.

Published
2004

14. Retraction: Identification of calcium-modulating cyclophilin ligand as a human host restriction to HIV-1 release overcome by Vpu.

Author

Varthakavi, Vasundhara, Heimann-Nichols, Ellen, Smith, Rita M, Sun, Yuehui, Bram, Richard J, Ali, Showkat, Rose, Jeremy, Ding, Lingmei, and Spearman, Paul

Subjects
*CYCLOPHILINS
Abstract

A correction to the article "Identification of Calcium-Modulating Cyclophilin Ligand as a Human Host Restriction to HIV-1 Release Overcome by Vpu," by Vasundhara Varthakavi and colleagues that was published online on May 25, 2008 is presented.

Published
2010
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