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287 results on '"Nichetti, Federico"'

1. Correction to: A phase II/III randomized clinical trial of CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative chemotherapy versus immediate resection in patIents with resecTable BiliarY tract cancers (BTC) at high risk for recurrence: PURITY study

Author

Niger, Monica, Nichetti, Federico, Fornaro, Lorenzo, Pircher, Chiara, Morano, Federica, Palermo, Federica, Rimassa, Lorenza, Pressiani, Tiziana, Berardi, Rossana, Gardini, Andrea Casadei, Sperti, Elisa, Salvatore, Lisa, Melisi, Davide, Bergamo, Francesca, Siena, Salvatore, Mosconi, Stefania, Longarini, Rafaella, Arcangeli, Giuseppina, Corallo, Salvatore, Delliponti, Laura, Tamberi, Stefano, Fea, Elena, Brandi, Giovanni, Rapposelli, Ilario Giovanni, Salati, Massimiliano, Baili, Paolo, Miceli, Rosalba, Ljevar, Silva, Cavallo, Ilaria, Sottotetti, Elisa, Martinetti, Antonia, Busset, Michele Droz Dit, Sposito, Carlo, Di Bartolomeo, Maria, Pietrantonio, Filippo, de Braud, Filippo, and Mazzaferro, Vincenzo

Published
2024
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2. A phase II/III randomized clinical trial of CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative chemotherapy versus immediate resection in patIents with resecTable BiliarY Tract Cancers (BTC) at high risk for recurrence: PURITY study

Author

Niger, Monica, Nichetti, Federico, Fornaro, Lorenzo, Pircher, Chiara, Morano, Federica, Palermo, Federica, Rimassa, Lorenza, Pressiani, Tiziana, Berardi, Rossana, Gardini, Andrea Casadei, Sperti, Elisa, Salvatore, Lisa, Melisi, Davide, Bergamo, Francesca, Siena, Salvatore, Mosconi, Stefania, Longarini, Raffaella, Arcangeli, Giuseppina, Corallo, Salvatore, Delliponti, Laura, Tamberi, Stefano, Fea, Elena, Brandi, Giovanni, Rapposelli, Ilario Giovanni, Salati, Massimiliano, Baili, Paolo, Miceli, Rosalba, Ljevar, Silva, Cavallo, Ilaria, Sottotetti, Elisa, Martinetti, Antonia, Busset, Michele Droz Dit, Sposito, Carlo, Di Bartolomeo, Maria, Pietrantonio, Filippo, de Braud, Filippo, and Mazzaferro, Vincenzo

Published
2024
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3. Durvalumab Plus Gemcitabine and Cisplatin Versus Gemcitabine and Cisplatin in Biliary Tract Cancer: a Real-World Retrospective, Multicenter Study

Author

Rimini, Margherita, Masi, Gianluca, Lonardi, Sara, Nichetti, Federico, Pressiani, Tiziana, Lavacchi, Daniele, Jessica, Lucchetti, Giordano, Guido, Scartozzi, Mario, Tamburini, Emiliano, Pastorino, Alessandro, Rapposelli, Ilario Giovanni, Daniele, Bruno, Martinelli, Erika, Garajova, Ingrid, Aprile, Giuseppe, Schirripa, Marta, Formica, Vincenzo, Salani, Francesca, Winchler, Costanza, Bergamo, Francesca, Balsano, Rita, Gusmaroli, Eleonora, Lorenzo, Angotti, Landriscina, Matteo, Pretta, Andrea, Toma, Ilaria, Pirrone, Chiara, Diana, Anna, Leone, Francesco, Brunetti, Oronzo, Brandi, Giovanni, Garattini, Silvio Ken, Satolli, Maria Antonietta, Rossari, Federico, Fornaro, Lorenzo, Niger, Monica, Zanuso, Valentina, De Rosa, Antonio, Ratti, Francesca, Aldrighetti, Luca, De Braud, Filippo, Foti, Silvia, Rizzato, Mario Domenico, Vivaldi, Caterina, Stefano, Cascinu, Rimassa, Lorenza, Antonuzzo, Lorenzo, and Casadei-Gardini, Andrea

Published
2024
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4. Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer: A large real-life worldwide population

Author

Rimini, Margherita, Fornaro, Lorenzo, Rizzato, Mario Domenico, Antonuzzo, Lorenzo, Rossari, Federico, Satake, Tomoyuki, Vandeputte, Hanne, Vivaldi, Caterina, Pressiani, Tiziana, Lucchetti, Jessica, Kim, Jin Won, Abidoye, Oluseyi, Rapposelli, Ilario Giovanni, Tamberi, Stefano, Finkelmeier, Fabian, Giordano, Guido, Nichetti, Federico, Chon, Hong Jae, Braconi, Chiara, Pirrone, Chiara, Castet, Florian, Tamburini, Emiliano, Yoo, Changhoon, Parisi, Alessandro, Diana, Anna, Scartozzi, Mario, Prager, Gerald W., Avallone, Antonio, Schirripa, Marta, Kim, Il Hwan, Perkhofer, Lukas, Oneda, Ester, Verrico, Monica, Adeva, Jorge, Chan, Stephen L., Spinelli, Gian Paolo, Personeni, Nicola, Garajova, Ingrid, Rodriquenz, Maria Grazia, Leo, Silvana, Salani, Francesca, De Rosa, Antonio, Lavacchi, Daniele, Foti, Silvia, Ikeda, Masafumi, Dekervel, Jeroen, Niger, Monica, Balsano, Rita, Tonini, Giuseppe, Kang, Minsu, Bekaii-Saab, Tanios, Esposito, Luca, Boccaccino, Alessandra, Himmelsbach, Vera, Landriscina, Matteo, Djaballah, Selma Ahcene, Zanuso, Valentina, Masi, Gianluca, Lonardi, Sara, Rimassa, Lorenza, and Casadei-Gardini, Andrea

Published
2024
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5. Safety and antitumor activity of metformin plus lanreotide in patients with advanced gastro-intestinal or lung neuroendocrine tumors: the phase Ib trial MetNET2

Author

Pusceddu, Sara, Corti, Francesca, Prinzi, Natalie, Nichetti, Federico, Ljevar, Silva, Busico, Adele, Cascella, Tommaso, Leporati, Rita, Oldani, Simone, Pircher, Chiara Carlotta, Coppa, Jorgelina, Resi, Veronica, Milione, Massimo, Maccauro, Marco, Miceli, Rosalba, Tamborini, Elena, Perrone, Federica, Spreafico, Carlo, Niger, Monica, Morano, Federica, Pietrantonio, Filippo, Seregni, Ettore, Mariani, Luigi, Mazzaferro, Vincenzo, Di Liberti, Giorgia, Fucà, Giovanni, de Braud, Filippo, and Vernieri, Claudio

Published
2023
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6. Prognostic and predictive impact of sex in locally advanced microsatellite instability high gastric or gastroesophageal junction cancer: An individual patient data pooled analysis of randomized clinical trials

Author

Raimondi, Alessandra, Kim, Young Woo, Kang, Won Ki, Langley, Ruth E., Choi, Yoon Young, Kim, Kyoung-Mee, Nankivell, Matthew Guy, Randon, Giovanni, Kook, Myeong-Cherl, An, Ji Yeong, Grabsch, Heike I., Prisciandaro, Michele, Nichetti, Federico, Noh, Sung Hoon, Sohn, Tae Sung, Kim, Sung, Wotherspoon, Andrew, Morano, Federica, Cunningham, David, Lee, Jeeyun, Cheong, Jae-Ho, Smyth, Elizabeth Catherine, and Pietrantonio, Filippo

Published
2024
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7. Negative hyperselection of elderly patients with RAS and BRAF wild-type metastatic colorectal cancer receiving initial panitumumab plus FOLFOX or 5-FU/LV

Author

Pietrantonio, Filippo, Bergamo, Francesca, Rossini, Daniele, Ghelardi, Filippo, De Grandis, Maria Caterina, Germani, Marco Maria, Barsotti, Giulia, Formica, Vincenzo, Frassineti, Giovanni Luca, Boscolo, Giorgia, Cinieri, Saverio, Di Donato, Samantha, Antonuzzo, Lorenzo, Antoniotti, Carlotta, Ambrosini, Margherita, Piva, Vittoria Matilde, Nichetti, Federico, Fassan, Matteo, Cremolini, Chiara, and Lonardi, Sara

Published
2023
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8. Optimal maintenance strategy following FOLFOX plus anti-EGFR induction therapy in patients with RAS wild type metastatic colorectal cancer: An individual patient data pooled analysis of randomised clinical trials

Author

Raimondi, Alessandra, Nichetti, Federico, Stahler, Arndt, Wasan, Harpreet S., Aranda, Enrique, Randon, Giovanni, Kurreck, Annika, Meade, Angela M., Díaz-Rubio, Eduardo, Niger, Monica, Stintzing, Sebastian, Palermo, Federica, Trarbach, Tanja, Prisciandaro, Michele, Sommerhäuser, Greta, Fisher, David, Morano, Federica, Pietrantonio, Filippo, and Modest, Dominik P.

Published
2023
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9. Clinical Outcomes After Progression on First-Line Therapies in IDH1 Mutated Versus Wild-Type Intrahepatic Cholangiocarcinoma Patients

Author

Rimini, Margherita, Fabregat-Franco, Carles, Persano, Mara, Burgio, Valentina, Bergamo, Francesca, Niger, Monica, Scartozzi, Mario, Rapposelli, Ilario Giovanni, Aprile, Giuseppe, Ratti, Francesca, Pedica, Federica, Verdaguer, Helena, Rizzato, Mario, Nichetti, Federico, Lai, Eleonora, Cappetta, Alessandro, Macarulla, Teresa, Fassan, Matteo, De Braud, Filippo, Pretta, Andrea, Simionato, Francesca, De Cobelli, Francesco, Aldrighetti, Luca, Fornaro, Lorenzo, Cascinu, Stefano, and Casadei-Gardini, Andrea

Published
2023
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10. Prognostic Role of a New Index Tested in European and Korean Advanced Biliary Tract Cancer Patients: the PECS Index

Author

Rovesti, Giulia, Leone, Francesco, Brandi, Giovanni, Fornaro, Lorenzo, Scartozzi, Mario, Niger, Monica, Yoo, Changhoon, Caputo, Francesco, Filippi, Roberto, Casagrande, Mariaelena, Silvestris, Nicola, Santini, Daniele, Faloppi, Luca, Palloni, Andrea, Aglietta, Massimo, Vivaldi, Caterina, Cho, Hyungwoo, Lai, Eleonora, Fenocchio, Elisabetta, Nichetti, Federico, Pella, Nicoletta, De Lorenzo, Stefania, Di Maio, Massimo, Vasile, Enrico, de Braud, Filippo, Jeong, Jae Ho, Aprile, Giuseppe, Orsi, Giulia, Cascinu, Stefano, and Casadei-Gardini, Andrea

Published
2022
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11. Molecular profile and its clinical impact of IDH1 mutated versus IDH1 wild type intrahepatic cholangiocarcinoma

Author

Rimini, Margherita, Fabregat-Franco, Carles, Burgio, Valentina, Lonardi, Sara, Niger, Monica, Scartozzi, Mario, Rapposelli, Ilario Giovanni, Aprile, Giuseppe, Ratti, Francesca, Pedica, Federica, Verdaguer, Helena, Rizzato, Mario, Nichetti, Federico, Lai, Eleonora, Cappetta, Alessandro, Macarulla, Teresa, Fassan, Matteo, De Braud, Filippo, Pretta, Andrea, Simionato, Francesca, De Cobelli, Francesco, Aldrighetti, Luca, Fornaro, Lorenzo, Cascinu, Stefano, and Casadei-Gardini, Andrea

Published
2022
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12. Lymphotoxin beta‐activated LTBR/NIK/RELB axis drives proliferation in cholangiocarcinoma.

Author

Xu, Kaiyu, Kessler, Annika, Nichetti, Federico, Hoffmeister‐Wittmann, Paula, Scherr, Anna‐Lena, Nader, Luisa, Kelmendi, Eblina, Schmitt, Nathalie, Schwab, Maximilian, García‐Beccaria, María, Sobol, Benjamin, Nieto, Osama Azzam, Isele, Hanna, Gärtner, Ulrike, Vaquero‐Siguero, Nuria, Volk, Julia, Korell, Felix, Mock, Andreas, Heide, Danijela, and Ramadori, Pierluigi

Subjects
TRANSCRIPTION factors, GENE expression, SMALL molecules, CELLULAR signal transduction, BILE ducts
Abstract

Background and Aims: Cholangiocarcinoma (CCA) is an aggressive malignancy arising from the intrahepatic (iCCA) or extrahepatic (eCCA) bile ducts with poor prognosis and limited treatment options. Prior evidence highlighted a significant contribution of the non‐canonical NF‐κB signalling pathway in initiation and aggressiveness of different tumour types. Lymphotoxin‐β (LTβ) stimulates the NF‐κB‐inducing kinase (NIK), resulting in the activation of the transcription factor RelB. However, the functional contribution of the non‐canonical NF‐κB signalling pathway via the LTβ/NIK/RelB axis in CCA carcinogenesis and progression has not been established. Methods: Human CCA‐derived cell lines and organoids were examined to determine the expression of NF‐κB pathway components upon activation or inhibition. Proliferation and cell death were analysed using real‐time impedance measurement and flow cytometry. Immunoblot, qRT‐PCR, RNA sequencing and in situ hybridization were employed to analyse gene and protein expression. Four in vivo models of iCCA were used to probe the activation and regulation of the non‐canonical NF‐κB pathway. Results: Exposure to LTα1/β2 activates the LTβ/NIK/RelB axis and promotes proliferation in CCA. Inhibition of NIK with the small molecule inhibitor B022 efficiently suppresses RelB expression in patient‐derived CCA organoids and nuclear co‐translocation of RelB and p52 stimulated by LTα1/β2 in CCA cell lines. In murine CCA, RelB expression is significantly increased and LTβ is the predominant ligand of the non‐canonical NF‐κB signalling pathway. Conclusions: Our study confirms that the non‐canonical NF‐κB axis LTβ/NIK/RelB drives cholangiocarcinogenesis and represents a candidate therapeutic target. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Molecular Tumor Board as a Clinical Tool for Converting Molecular Data Into Real-World Patient Care

Author

Vingiani, Andrea, Agnelli, Luca, Duca, Matteo, Lorenzini, Daniele, Damian, Silvia, Proto, Claudia, Niger, Monica, Nichetti, Federico, Tamborini, Elena, Perrone, Federica, Piccolo, Alberta, Manoukian, Siranoush, Azzollini, Jacopo, Brambilla, Marta, Colombo, Elena, Lopez, Salvatore, Vernieri, Claudio, Marra, Francesca, Conca, Elena, Busico, Adele, Capone, Iolanda, Bozzi, Fabio, Angelini, Marta, Devecchi, Andrea, Salvatori, Rebecca, De Micheli, Valentina, Baggi, Anna, Pasini, Silvia, Jommi, Claudio, Ladisa, Vito, Apolone, Giovanni, De Braud, Filippo, and Pruneri, Giancarlo

Published
2023
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14. Thrombin generation predicts early recurrence in breast cancer patients

Author

Marchetti, Marina, Giaccherini, Cinzia, Masci, Giovanna, Verzeroli, Cristina, Russo, Laura, Celio, Luigi, Sarmiento, Roberta, Gamba, Sara, Tartari, Carmen J., Diani, Erika, Vignoli, Alfonso, Malighetti, Paolo, Spinelli, Daniele, Kuderer, Nicole M., Nichetti, Federico, Minelli, Mauro, Tondini, Carlo, Barni, Sandro, Giuliani, Francesco, Petrelli, Fausto, D’Alessio, Andrea, Gasparini, Giampietro, Labianca, Roberto, Santoro, Armando, De Braud, Filippo, Falanga, Anna, Schieppati, Francesca, Martinetti, Antonia, Gennaro, Elisabetta, and Ghilardi, Mara

Published
2020
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15. Clinical and prognostic characteristics of early onset metastatic pancreatic cancer.

Author

Pretta, Andrea, primary, Giampieri, Riccardo, additional, Nichetti, Federico, additional, Ziranu, Pina, additional, Lupi, Alessio, additional, Cimbro, Erika, additional, Andena, Paola, additional, Felicetti, Cristiano, additional, Pircher, Chiara Carlotta, additional, Gusmaroli, Eleonora, additional, Donisi, Clelia, additional, Balconi, Francesca, additional, Mariani, Stefano, additional, Lai, Eleonora, additional, Puzzoni, Marco, additional, Pusceddu, Valeria, additional, Berardi, Rossana, additional, Niger, Monica, additional, and Scartozzi, Mario, additional

Published
2024
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16. Comparison between different therapeutic sequences in patients affected by metastatic pancreatic ductal adenocarcinoma.

Author

Pretta, Andrea, primary, Giampieri, Riccardo, additional, Nichetti, Federico, additional, Ziranu, Pina, additional, Lupi, Alessio, additional, Moledda, Giusy, additional, Andena, Paola, additional, Felicetti, Cristiano, additional, D'Agata, Alessandra Pia, additional, Pircher, Chiara Carlotta, additional, Codipietro, Claudia, additional, Rota, Simone, additional, Rizzo, Daiana, additional, Sanna, Giorgia, additional, Lai, Eleonora, additional, Puzzoni, Marco, additional, Pusceddu, Valeria, additional, Berardi, Rossana, additional, Niger, Monica, additional, and Scartozzi, Mario, additional

Published
2024
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17. Supplementary Table S1 from Negative Hyperselection of Patients with HER2+ and RAS Wild-Type Metastatic Colorectal Cancer Receiving Dual HER2 Blockade: the PRESSING-HER2 Study

Author

Randon, Giovanni, primary, Nakamura, Yoshiaki, primary, Yaeger, Rona, primary, Lonardi, Sara, primary, Cremolini, Chiara, primary, Elez, Elena, primary, Nichetti, Federico, primary, Ghelardi, Filippo, primary, Nasca, Vincenzo, primary, Bergamo, Francesca, primary, Conca, Veronica, primary, Ros, Javier, primary, Bando, Hideaki, primary, Maddalena, Giulia, primary, Oldani, Simone, primary, Prisciandaro, Michele, primary, Raimondi, Alessandra, primary, Schrock, Alexa B., primary, Agnelli, Luca, primary, Walch, Henry, primary, Yoshino, Takayuki, primary, and Pietrantonio, Filippo, primary

Published
2024
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18. Supplementary Figure S3 from Negative Hyperselection of Patients with HER2+ and RAS Wild-Type Metastatic Colorectal Cancer Receiving Dual HER2 Blockade: the PRESSING-HER2 Study

Author

Randon, Giovanni, primary, Nakamura, Yoshiaki, primary, Yaeger, Rona, primary, Lonardi, Sara, primary, Cremolini, Chiara, primary, Elez, Elena, primary, Nichetti, Federico, primary, Ghelardi, Filippo, primary, Nasca, Vincenzo, primary, Bergamo, Francesca, primary, Conca, Veronica, primary, Ros, Javier, primary, Bando, Hideaki, primary, Maddalena, Giulia, primary, Oldani, Simone, primary, Prisciandaro, Michele, primary, Raimondi, Alessandra, primary, Schrock, Alexa B., primary, Agnelli, Luca, primary, Walch, Henry, primary, Yoshino, Takayuki, primary, and Pietrantonio, Filippo, primary

Published
2024
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19. Data from Negative Hyperselection of Patients with HER2+ and RAS Wild-Type Metastatic Colorectal Cancer Receiving Dual HER2 Blockade: the PRESSING-HER2 Study

Author

Randon, Giovanni, primary, Nakamura, Yoshiaki, primary, Yaeger, Rona, primary, Lonardi, Sara, primary, Cremolini, Chiara, primary, Elez, Elena, primary, Nichetti, Federico, primary, Ghelardi, Filippo, primary, Nasca, Vincenzo, primary, Bergamo, Francesca, primary, Conca, Veronica, primary, Ros, Javier, primary, Bando, Hideaki, primary, Maddalena, Giulia, primary, Oldani, Simone, primary, Prisciandaro, Michele, primary, Raimondi, Alessandra, primary, Schrock, Alexa B., primary, Agnelli, Luca, primary, Walch, Henry, primary, Yoshino, Takayuki, primary, and Pietrantonio, Filippo, primary

Published
2024
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20. NALIRIFOX, FOLFIRINOX, and Gemcitabine With Nab-Paclitaxel as First-Line Chemotherapy for Metastatic Pancreatic Cancer

Author

Nichetti, Federico, primary, Rota, Simone, additional, Ambrosini, Paolo, additional, Pircher, Chiara, additional, Gusmaroli, Eleonora, additional, Droz Dit Busset, Michele, additional, Pusceddu, Sara, additional, Sposito, Carlo, additional, Coppa, Jorgelina, additional, Morano, Federica, additional, Pietrantonio, Filippo, additional, Di Bartolomeo, Maria, additional, Mariani, Luigi, additional, Mazzaferro, Vincenzo, additional, de Braud, Filippo, additional, and Niger, Monica, additional

Published
2024
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21. Durvalumab Plus Gemcitabine and Cisplatin in Advanced Biliary Tract Cancer: A Large Real-Life Worldwide Population

Author

Rimini, Margherita, primary, Fornaro, Lorenzo, additional, Rizzato, Mario, additional, Antonuzzo, Lorenzo, additional, Rossari, Federico, additional, Satake, Tomoyuki, additional, Vandeputte, Hanne, additional, Vivaldi, Caterina, additional, Pressiani, Tiziana, additional, Lucchetti, Jessica, additional, Kim, Jin Won, additional, Abidoye, Oluseyi, additional, Rapposelli, Ilario Giovanni, additional, Tamberi, Stefano, additional, Finkelmeier, Fabian, additional, Giordano, Guido, additional, Nichetti, Federico, additional, Chon, Hong Jae, additional, Braconi, Chiara, additional, Pirrone, Chiara, additional, Castet, Florian, additional, Tamburini, Emiliano, additional, Yoo, Changhoon, additional, Parisi, Alessandro, additional, Diana, Anna, additional, Scartozzi, Mario, additional, Prager, Gerald, additional, Avallone, Antonio, additional, Schirripa, Marta, additional, Kim, Il Hwan, additional, Perkhofer, Lukas, additional, Oneda, Ester, additional, Verrico, Monica, additional, Adeva, Jorge, additional, Chan, Stephen L., additional, Spinelli, Gian Paolo, additional, Personeni, Nicola, additional, Garajova, Ingrid, additional, Rodriquenz, Maria Grazia, additional, Leo, Silvana, additional, Salani, Francesca, additional, De Rosa, Antonio, additional, Lavacchi, Daniele, additional, Foti, Silvia, additional, Ikeda, Masafumi, additional, Dekervel, Jeroen, additional, Niger, Monica, additional, Balsano, Rita, additional, Tonini, Giuseppe, additional, Kang, Minsu, additional, Bekaii-Saab, Tanios, additional, Esposito, Luca, additional, Boccaccino, Alessandra, additional, Himmelsbach, Vera, additional, Landriscina, Matteo, additional, Djaballah, Selma Ahcene, additional, Zanuso, Valentina, additional, Masi, Gianluca, additional, Lonardi, Sara, additional, Rimassa, Lorenza, additional, and Casadei Gardini, Andrea, additional

Published
2024
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25. Second-line treatment efficacy and toxicity in older vs. non-older patients with advanced gastric cancer: A multicentre real-world study

Author

Fanotto, Valentina, Fornaro, Lorenzo, Bordonaro, Roberto, Rosati, Gerardo, Rimassa, Lorenza, Di Donato, Samantha, Santini, Daniele, Tomasello, Gianluca, Leone, Francesco, Silvestris, Nicola, Stragliotto, Silvia, Scartozzi, Mario, Giampieri, Riccardo, Nichetti, Federico, Antonuzzo, Lorenzo, Cinieri, Saverio, Avallone, Antonio, Pellegrino, Antonio, Melisi, Davide, Vasile, Enrico, Gerratana, Lorenzo, and Aprile, Giuseppe

Published
2019
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26. Etiology-independent activation of the LTβ-LTβR-RELB axis drives aggressiveness and predicts poor prognosis in HCC

Author

Scherr, Anna-Lena, primary, Nader, Luisa, additional, Xu, Kaiyu, additional, Elssner, Christin, additional, Ridder, Dirk A., additional, Nichetti, Federico, additional, Mastel, Manuel, additional, Fritzsche, Sarah, additional, Kelmendi, Eblina, additional, Schmitt, Nathalie, additional, Hoffmeister-Wittmann, Paula, additional, Weiler, Sofia M. E., additional, Korell, Felix, additional, Albrecht, Thomas, additional, Schwab, Maximilian, additional, Isele, Hanna, additional, Kessler, Annika, additional, Hüllein, Jennifer, additional, Seretny, Agnieszka, additional, Ye, Liangtao, additional, Urbanik, Toni, additional, Welte, Stefan, additional, Leblond, Anne-Laure, additional, Heilig, Christoph E., additional, Rahbari, Mohammad, additional, Ali, Adnan, additional, Gallage, Suchira, additional, Lenoir, Bénédicte, additional, Wilhelm, Nina, additional, Gärtner, Ulrike, additional, Ogrodnik, Simon J., additional, Springfeld, Christoph, additional, Tschaharganeh, Darjus, additional, Fröhling, Stefan, additional, Longerich, Thomas, additional, Schulze-Bergkamen, Henning, additional, Jäger, Dirk, additional, Brandl, Lydia, additional, Schirmacher, Peter, additional, Straub, Beate K., additional, Weber, Achim, additional, De Toni, Enrico N., additional, Goeppert, Benjamin, additional, Heikenwalder, Mathias, additional, Jackstadt, Rene, additional, Roessler, Stephanie, additional, Breuhahn, Kai, additional, and Köhler, Bruno C., additional

Published
2023
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27. Comparative Genomic Analysis and Clinical Outcomes of BRAF-mutated Advanced Biliary Tract Cancers

Author

Tang, Tin-Yun, primary, Nichetti, Federico, additional, Kaplan, Benjamin, additional, Lonardi, Sara, additional, Pietrantonio, Filippo, additional, Salvatore, Lisa, additional, Vivaldi, Caterina, additional, Rimassa, Lorenza, additional, de Braud, Filippo, additional, Rizzato, Mario Domenico, additional, Pavlick, Dean, additional, Chu, Randy, additional, Danner De Armas, Anaemy, additional, Sharaf, Radwa, additional, Sokol, Ethan, additional, Rodon Ahnert, Jordi, additional, Ross, Jeffrey S., additional, Javle, Milind, additional, and Niger, Monica, additional

Published
2023
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30. Negative hyper-selection of patients with HER2-positive and RAS wild-type metastatic colorectal cancer receiving dual HER2 blockade: the PRESSING-HER2 study

Author

Randon, Giovanni, primary, Nakamura, Yoshiaki, additional, Yaeger, Rona, additional, Lonardi, Sara, additional, Cremolini, Chiara, additional, Élez, Elena, additional, Nichetti, Federico, additional, Ghelardi, Filippo, additional, Nasca, Vincenzo, additional, Bergamo, Francesca, additional, Conca, Veronica, additional, Ros, Javier, additional, Bando, Hideaki, additional, Maddalena, Giulia, additional, Oldani, Simone, additional, Prisciandaro, Michele, additional, Raimondi, Alessandra, additional, Schrock, Alexa B., additional, Agnelli, Luca, additional, Walch, Henry, additional, Yoshino, Takayuki, additional, and Pietrantonio, Filippo, additional

Published
2023
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31. Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer: An early exploratory analysis of real‐world data

Author

Rimini, Margherita, primary, Fornaro, Lorenzo, additional, Lonardi, Sara, additional, Niger, Monica, additional, Lavacchi, Daniele, additional, Pressiani, Tiziana, additional, Lucchetti, Jessica, additional, Giordano, Guido, additional, Pretta, Andrea, additional, Tamburini, Emiliano, additional, Pirrone, Chiara, additional, Rapposelli, Ilario Giovanni, additional, Diana, Anna, additional, Martinelli, Erika, additional, Garajová, Ingrid, additional, Simionato, Francesca, additional, Schirripa, Marta, additional, Formica, Vincenzo, additional, Vivaldi, Caterina, additional, Caliman, Enrico, additional, Rizzato, Mario Domenico, additional, Zanuso, Valentina, additional, Nichetti, Federico, additional, Angotti, Lorenzo, additional, Landriscina, Matteo, additional, Scartozzi, Mario, additional, Ramundo, Matteo, additional, Pastorino, Alessandro, additional, Daniele, Bruno, additional, Cornara, Noemi, additional, Persano, Mara, additional, Gusmaroli, Eleonora, additional, Cerantola, Riccardo, additional, Salani, Francesca, additional, Ratti, Francesca, additional, Aldrighetti, Luca, additional, Cascinu, Stefano, additional, Rimassa, Lorenza, additional, Antonuzzo, Lorenzo, additional, and Casadei‐Gardini, Andrea, additional

Published
2023
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32. Vinorelbine in BRAF V600E mutated metastatic colorectal cancer: a prospective multicentre phase II clinical study

Author

Cremolini, Chiara, Pietrantonio, Filippo, Tomasello, Gianluca, Dadduzio, Vincenzo, Moretto, Roberto, Morano, Federica, Schirripa, Marta, Antoniotti, Carlotta, Fucà, Giovanni, Bergamo, Francesca, Rossini, Daniele, Nichetti, Federico, Ziampiri, Stamatia, Ghidini, Michele, Marmorino, Federica, Prisciandaro, Michele, Falcone, Alfredo, De Braud, Filippo, Loupakis, Fotios, and Lonardi, Sara

Published
2017
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34. Peripheral blood lymphocytes predict clinical outcomes in hormone receptor-positive HER2-negative advanced breast cancer patients treated with CDK4/6 inhibitors.

Author

Zattarin, Emma, Mariani, Luigi, Menichetti, Alice, Leporati, Rita, Provenzano, Leonardo, Ligorio, Francesca, Fucà, Giovanni, Lobefaro, Riccardo, Lalli, Luca, Vingiani, Andrea, Nichetti, Federico, Griguolo, Gaia, Sirico, Marianna, Bernocchi, Ottavia, Marra, Antonio, Corti, Chiara, Zagami, Paola, Agostinetto, Elisa, Jacobs, Flavia, and Di Mauro, Pierluigi

Abstract

Background: Cyclin-Dependent Kinase 4/6 inhibitors (CDK4/6i) combined with Endocrine Therapy (ET) are the standard treatment for patients with Hormone Receptor-positive/HER2-negative advanced breast cancer (HR+/HER2− aBC). Objectives: While CDK4/6i are known to reduce several peripheral blood cells, such as neutrophils, lymphocytes and platelets, the impact of these modulations on clinical outcomes is unknown. Design: A multicenter, retrospective-prospective Italian study. Methods: We investigated the association between baseline peripheral blood cells, or their early modifications (i.e. 2 weeks after treatment initiation), and the progression-free survival (PFS) of HR+/HER2− aBC patients treated with ETs plus CDK4/6i. Random Forest models were used to select covariates associated with patient PFS among a large list of patient- and tumor-related variables. Results: We evaluated 638 HR+/HER2− aBC patients treated with ET plus CDK4/6i at six Italian Institutions between January 2017 and May 2021. High baseline lymphocyte counts were independently associated with longer PFS [median PFS (mPFS) 20.1 versus 13.2 months in high versus low lymphocyte patients, respectively; adjusted Hazard Ratio (aHR): 0.78; 95% confidence interval (CI): 0.66–0.92; p = 0.0144]. Moreover, patients experiencing a lower early reduction of lymphocyte counts had significantly longer PFS when compared to patients undergoing higher lymphocyte decrease (mPFS 18.1 versus 14.5 months; aHR: 0.82; 95% CI: 0.73–0.93; p = 0.0037). Patients with high baseline lymphocytes and undergoing a lower reduction, or even an increase, of lymphocyte counts during CDK4/6i therapy experienced the longest PFS, while patients with lower baseline lymphocytes and undergoing a higher decrease of lymphocytes had the lowest PFS (mPFS 21.4 versus 11 months, respectively). Conclusion: Baseline and on-treatment modifications of peripheral blood lymphocytes have independent prognostic value in HR+/HER2− aBC patients. This study supports the implementation of clinical strategies to boost antitumor immunity in patients with HR+/HER2− aBC treated with ETs plus CDK4/6i. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Evaluation of clinical benefit and progression-free survival ratio of targeted treatments in a prospective cohort study of patients with biliary tract cancers.

Author

Niger, Monica, primary, Nichetti, Federico, additional, Vingiani, Andrea, additional, Pircher, Chiara Carlotta, additional, Agnelli, Luca, additional, Conca, Elena, additional, Tamborini, Elena, additional, Perrone, Federica, additional, Gusmaroli, Eleonora, additional, Franza, Andrea, additional, Corti, Francesca, additional, Provenzano, Leonardo, additional, Morano, Federica, additional, Pruneri, Giancarlo, additional, Di Bartolomeo, Maria, additional, Pietrantonio, Filippo, additional, and De Braud, Filippo G., additional

Published
2023
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39. Corrigendum to ‘Gene mutational profile of BRCAness and clinical implication in predicting response to platinum-based chemotherapy in patients with intrahepatic cholangiocarcinoma’ [Euro J Cancer 171 (2022) 232–241]

Author

Rimini, Margherita, primary, Macarulla, Teresa, additional, Burgio, Valentina, additional, Lonardi, Sara, additional, Niger, Monica, additional, Scartozzi, Mario, additional, Rapposelli, Ilario G., additional, Aprile, Giuseppe, additional, Ratti, Francesca, additional, Pedica, Federica, additional, Verdaguer, Helena, additional, Nappo, Floriana, additional, Nichetti, Federico, additional, Lai, Eleonora, additional, Valgiusti, Martina, additional, Cappetta, Alessandro, additional, Fabregat-Franco, Carles, additional, Fassan, Matteo, additional, De Braud, Filippo, additional, Puzzoni, Marco, additional, Frassineti, Giovanni L., additional, Simionato, Francesca, additional, De Cobelli, Francesco, additional, Aldrighetti, Luca, additional, Fornaro, Lorenzo, additional, Cascinu, Stefano, additional, and Casadei-Gardini, Andrea, additional

Published
2022
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40. Next-generation sequencing analysis of cholangiocarcinoma identifies distinct IDH1-mutated clusters

Author

Rimini, Margherita, primary, Loi, Eleonora, additional, Fabregat-Franco, Carles, additional, Burgio, Valentina, additional, Lonardi, Sara, additional, Niger, Monica, additional, Scartozzi, Mario, additional, Raposelli, Ilario G., additional, Aprile, Giuseppe, additional, Ratti, Francesca, additional, Pedica, Federica, additional, Verdaguer, Helena, additional, Rizzato, Mario, additional, Nichetti, Federico, additional, Lai, Eleonora, additional, Cappetta, Alessandro, additional, Macarulla, Teresa, additional, Fassan, Matteo, additional, De Braud, Filippo, additional, Pretta, Andrea, additional, Simionato, Francesca, additional, De Cobelli, Francesco, additional, Aldrighetti, Luca, additional, Fornaro, Lorenzo, additional, Cascinu, Stefano, additional, Zavattari, Patrizia, additional, and Casadei-Gardini, Andrea, additional

Published
2022
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41. Bcl‐x Las prognostic marker and potential therapeutic target in cholangiocarcinoma

Author

Hoffmeister‐Wittmann, Paula, primary, Mock, Andreas, additional, Nichetti, Federico, additional, Korell, Felix, additional, Heilig, Christoph E., additional, Scherr, Anna‐Lena, additional, Günther, Michael, additional, Albrecht, Thomas, additional, Kelmendi, Eblina, additional, Xu, Kaiyu, additional, Nader, Luisa, additional, Kessler, Annika, additional, Schmitt, Nathalie, additional, Fritzsche, Sarah, additional, Weiler, Sofia, additional, Sobol, Benjamin, additional, Stenzinger, Albrecht, additional, Boeck, Stefan, additional, Westphalen, Christoph B., additional, Schulze‐Osthoff, Klaus, additional, Trojan, Jörg, additional, Kindler, Thomas, additional, Weichert, Wilko, additional, Spiekermann, Karsten, additional, Bitzer, Michael, additional, Folprecht, Gunnar, additional, Illert, Anna L., additional, Boerries, Melanie, additional, Klauschen, Frederick, additional, Ochsenreither, Sebastian, additional, Siveke, Jens, additional, Bauer, Sebastian, additional, Glimm, Hanno, additional, Brors, Benedikt, additional, Hüllein, Jennifer, additional, Hübschmann, Daniel, additional, Uhrig, Sebastian, additional, Horak, Peter, additional, Kreutzfeldt, Simon, additional, Banales, Jesus M., additional, Springfeld, Christoph, additional, Jäger, Dirk, additional, Schirmacher, Peter, additional, Roessler, Stephanie, additional, Ormanns, Steffen, additional, Goeppert, Benjamin, additional, Fröhling, Stefan, additional, and Köhler, Bruno C., additional

Published
2022
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42. Case Report: Prolonged clinical benefit with sequential trastuzumab-containing treatments in a patient with advanced extramammary Paget disease of the groin

Author

Zattarin, Emma, primary, Nichetti, Federico, additional, Ligorio, Francesca, additional, Mazzeo, Laura, additional, Lobefaro, Riccardo, additional, Fucà, Giovanni, additional, Peverelli, Giorgia, additional, Vingiani, Andrea, additional, Bianchi, Giulia V., additional, Capri, Giuseppe, additional, de Braud, Filippo, additional, and Vernieri, Claudio, additional

Published
2022
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43. Gene mutational profile of BRCAness and clinical implication in predicting response to platinum-based chemotherapy in patients with intrahepatic cholangiocarcinoma

Author

Rimini, Margherita, primary, Macarulla, Teresa, additional, Burgio, Valentina, additional, Lonardi, Sara, additional, Niger, Monica, additional, Scartozzi, Mario, additional, Rapposelli, Ilario G., additional, Aprile, Giuseppe, additional, Ratti, Francesca, additional, Pedica, Federica, additional, Verdaguer, Helena, additional, Nappo, Floriana, additional, Nichetti, Federico, additional, Lai, Eleonora, additional, Valgiusti, Martina, additional, Cappetta, Alessandro, additional, Fabregat-Franco, Carles, additional, Fassan, Matteo, additional, De Braud, Filippo, additional, Puzzoni, Marco, additional, Frassineti, Giovanni L., additional, Simionato, Francesca, additional, De Cobelli, Francesco, additional, Aldrighetti, Luca, additional, Fornaro, Lorenzo, additional, Cascinu, Stefano, additional, and Casadei-Gardini, Andrea, additional

Published
2022
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44. Platinum sensitivity in patients with IDH1/2 mutated vs wild‐type intrahepatic cholangiocarcinoma: A propensity score‐based study

Author

Niger, Monica, primary, Nichetti, Federico, additional, Casadei‐Gardini, Andrea, additional, Rizzato, Mario Domenico, additional, Pircher, Chiara, additional, Bini, Marta, additional, Franza, Andrea, additional, Rimini, Margherita, additional, Burgio, Valentina, additional, Sposetti, Caterina, additional, Fornaro, Lorenzo, additional, Rapposelli, Ilario Giovanni, additional, D'Amico, Francesco Enrico, additional, Aprile, Giuseppe, additional, Vivaldi, Caterina, additional, Frassineti, Giovanni Luca, additional, Milione, Massimo, additional, Leoncini, Giuseppe, additional, Cappetta, Alessandro, additional, Vasile, Enrico, additional, Fassan, Matteo, additional, Morano, Federica, additional, Perrone, Federica, additional, Tamborini, Elena, additional, Pruneri, Giancarlo, additional, Lonardi, Sara, additional, Mazzaferro, Vincenzo, additional, Pietrantonio, Filippo, additional, Di Bartolomeo, Maria, additional, and de Braud, Filippo, additional

Published
2022
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45. The genomic landscape of IDH1 mutant intrahepatic cholangiocarcinoma: a multicentre comprehensive analysis

Author

Rimini, Margherita, primary, Macarulla, Teresa Mercade, additional, Burgio, Valentina, additional, Lonardi, Sara, additional, Niger, Monica, additional, Scartozzi, Mario, additional, Raposelli, Ilario, additional, Aprile, Giuseppe, additional, Ratti, Francesca, additional, Pedica, Federica, additional, Verdaguer, Helena, additional, Nappo, Floriana, additional, Nichetti, Federico, additional, Lai, Eleonora, additional, Valgiusti, Martina, additional, Cappetta, Alessandro, additional, Fabregat, Carles, additional, Fassan, Matteo, additional, De Braud, Filippo, additional, Puzzoni, Marco, additional, Frassineti, Giovanni Luca, additional, Simionato, Francesca, additional, De Cobelli, Francesco, additional, Aldrighetti, Luca, additional, Fornaro, Lorenzo, additional, Cascinu, Stefano, additional, and Gardini, Andrea Casadei, additional

Published
2022
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46. RELB activation drives tumour aggressiveness and predicts prognosis in hepatocellular carcinoma

Author

Nader, Luisa, primary, Nichetti, Federico, additional, Scherr, Anna-Lena, additional, Elssner, Christin, additional, Ridder, Dirk, additional, Fritzsche, Sarah, additional, Weiler, Sofia, additional, Albrecht, Thomas, additional, Kessler, Annika, additional, Schmitt, Nathalie, additional, Korell, Felix, additional, Ye, Liangtao, additional, Urbanik, Toni, additional, Heilig, Christoph, additional, Rahbari, Mohammad, additional, Brandl, Lydia, additional, Springfeld, Christoph, additional, Longerich, Thomas, additional, Schulze-Bergkamen, Henning, additional, Jäger, Dirk, additional, Fröhling, Stefan, additional, Schirmacher, Peter, additional, Straub, Beate, additional, Weber, Achim, additional, Heikenwälder, Mathias, additional, de Toni, Enrico, additional, Goeppert, Benjamin, additional, Roessler, Stephanie, additional, Breuhahn, Kai, additional, and Köhler, Bruno, additional

Published
2022
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47. MGMT inactivation as a new biomarker in patients with advanced biliary tract cancers

Author

Niger, Monica, primary, Nichetti, Federico, additional, Casadei‐Gardini, Andrea, additional, Morano, Federica, additional, Pircher, Chiara, additional, Tamborini, Elena, additional, Perrone, Federica, additional, Canale, Matteo, additional, Lipka, Daniel B., additional, Vingiani, Andrea, additional, Agnelli, Luca, additional, Dobberkau, Anna, additional, Hüllein, Jennifer, additional, Korell, Felix, additional, Heilig, Christoph E., additional, Pusceddu, Sara, additional, Corti, Francesca, additional, Droz, Michele, additional, Ulivi, Paola, additional, Prisciandaro, Michele, additional, Antista, Maria, additional, Bini, Marta, additional, Cattaneo, Laura, additional, Milione, Massimo, additional, Glimm, Hanno, additional, Köhler, Bruno C., additional, Pruneri, Giancarlo, additional, Hübschmann, Daniel, additional, Fröhling, Stefan, additional, Mazzaferro, Vincenzo, additional, Pietrantonio, Filippo, additional, Di Bartolomeo, Maria, additional, and de Braud, Filippo, additional

Published
2022
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49. sj-docx-3-tam-10.1177_17588359221108687 – Supplemental material for Efficacy of mRNA anti-SARS-CoV-2 vaccination and dynamics of humoral immune response in patients with solid tumors: results from the institutional registry of an Italian tertiary cancer center

Author

Fucà, Giovanni, Lecchi, Mara, Ciniselli, Chiara Maura, Ottini, Arianna, Spagnoletti, Andrea, Mazzeo, Laura, Morelli, Daniele, Frati, Paola, Stroscia, Martina, Ebrahem, Elisabella, Sottotetti, Elisa, Galli, Giulia, D’Elia, Maria Grazia, Lobefaro, Riccardo, Ducceschi, Monika, Di Guardo, Lorenza, Bhoori, Sherrie, Provenzano, Salvatore, Platania, Marco, Niger, Monica, Colombo, Elena, Nichetti, Federico, Duca, Matteo, Rivoltini, Licia, Mortarini, Roberta, Baili, Paolo, Apolone, Giovanni, de Braud, Filippo, Verderio, Paolo, and Damian, Silvia

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-3-tam-10.1177_17588359221108687 for Efficacy of mRNA anti-SARS-CoV-2 vaccination and dynamics of humoral immune response in patients with solid tumors: results from the institutional registry of an Italian tertiary cancer center by Giovanni Fuc’, Mara Lecchi, Chiara Maura Ciniselli, Arianna Ottini, Andrea Spagnoletti, Laura Mazzeo, Daniele Morelli, Paola Frati, Martina Stroscia, Elisabella Ebrahem, Elisa Sottotetti, Giulia Galli, Maria Grazia D’Elia, Riccardo Lobefaro, Monika Ducceschi, Lorenza Di Guardo, Sherrie Bhoori, Salvatore Provenzano, Marco Platania, Monica Niger, Elena Colombo, Federico Nichetti, Matteo Duca, Licia Rivoltini, Roberta Mortarini, Paolo Baili, Giovanni Apolone, Filippo de Braud, Paolo Verderio and Silvia Damian in Therapeutic Advances in Medical Oncology

Published
2022
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50. sj-docx-4-tam-10.1177_17588359221108687 – Supplemental material for Efficacy of mRNA anti-SARS-CoV-2 vaccination and dynamics of humoral immune response in patients with solid tumors: results from the institutional registry of an Italian tertiary cancer center

Author

Fucà, Giovanni, Lecchi, Mara, Ciniselli, Chiara Maura, Ottini, Arianna, Spagnoletti, Andrea, Mazzeo, Laura, Morelli, Daniele, Frati, Paola, Stroscia, Martina, Ebrahem, Elisabella, Sottotetti, Elisa, Galli, Giulia, D’Elia, Maria Grazia, Lobefaro, Riccardo, Ducceschi, Monika, Di Guardo, Lorenza, Bhoori, Sherrie, Provenzano, Salvatore, Platania, Marco, Niger, Monica, Colombo, Elena, Nichetti, Federico, Duca, Matteo, Rivoltini, Licia, Mortarini, Roberta, Baili, Paolo, Apolone, Giovanni, de Braud, Filippo, Verderio, Paolo, and Damian, Silvia

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-4-tam-10.1177_17588359221108687 for Efficacy of mRNA anti-SARS-CoV-2 vaccination and dynamics of humoral immune response in patients with solid tumors: results from the institutional registry of an Italian tertiary cancer center by Giovanni Fuc’, Mara Lecchi, Chiara Maura Ciniselli, Arianna Ottini, Andrea Spagnoletti, Laura Mazzeo, Daniele Morelli, Paola Frati, Martina Stroscia, Elisabella Ebrahem, Elisa Sottotetti, Giulia Galli, Maria Grazia D’Elia, Riccardo Lobefaro, Monika Ducceschi, Lorenza Di Guardo, Sherrie Bhoori, Salvatore Provenzano, Marco Platania, Monica Niger, Elena Colombo, Federico Nichetti, Matteo Duca, Licia Rivoltini, Roberta Mortarini, Paolo Baili, Giovanni Apolone, Filippo de Braud, Paolo Verderio and Silvia Damian in Therapeutic Advances in Medical Oncology

Published
2022
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