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2. MPXV DNA kinetics in bloodstream and other body fluids samples

Author

Meschi, Silvia, Colavita, Francesca, Carletti, Fabrizio, Mazzotta, Valentina, Matusali, Giulia, Specchiarello, Eliana, Ascoli Bartoli, Tommaso, Mondi, Annalisa, Minosse, Claudia, Giancola, Maria Letizia, Pinnetti, Carmela, Valli, Maria Beatrice, Lapa, Daniele, Mizzoni, Klizia, Sullivan, David J., Ou, Jiangda, Focosi, Daniele, Girardi, Enrico, Nicastri, Emanuele, Antinori, Andrea, and Maggi, Fabrizio

Published
2024
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4. Transitions of blood immune endotypes and improved outcome by anakinra in COVID-19 pneumonia: an analysis of the SAVE-MORE randomized controlled trial

Author

Kyriazopoulou, Evdoxia, Hasin-Brumshtein, Yehudit, Midic, Uros, Poulakou, Garyfallia, Milionis, Haralampos, Metallidis, Simeon, Astriti, Myrto, Fragkou, Archontoula, Rapti, Aggeliki, Taddei, Eleonora, Kalomenidis, Ioannis, Chrysos, Georgios, Angheben, Andrea, Kainis, Ilias, Alexiou, Zoi, Castelli, Francesco, Serino, Francesco Saverio, Bakakos, Petros, Nicastri, Emanuele, Tzavara, Vasiliki, Ioannou, Sofia, Dagna, Lorenzo, Dimakou, Katerina, Tzatzagou, Glykeria, Chini, Maria, Bassetti, Matteo, Kotsis, Vasileios, Tsoukalas, Dionysios G., Selmi, Carlo, Konstantinou, Alexandra, Samarkos, Michael, Doumas, Michael, Masgala, Aikaterini, Pagkratis, Konstantinos, Argyraki, Aikaterini, Akinosoglou, Karolina, Symbardi, Styliani, Netea, Mihai G., Panagopoulos, Periklis, Dalekos, George N., Liesenfeld, Oliver, Sweeney, Timothy E., Khatri, Purvesh, and Giamarellos-Bourboulis, Evangelos J.

Published
2024
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6. Guinea worm disease: A neglected diseases on the verge of eradication

Author

Pellegrino, Carmen, Patti, Giulia, Camporeale, Michele, Belati, Alessandra, Novara, Roberta, Papagni, Roberta, Frallonardo, Luisa, Diella, Lucia, Guido, Giacomo, De Vita, Elda, Totaro, Valentina, Segala, Francesco Vladimiro, Veronese, Nicola, Cotugno, Sergio, Bavaro, Davide Fiore, Putoto, Giovanni, Bevilacqua, Nazario, Castellani, Chiara, Nicastri, Emanuele, Saracino, Annalisa, and Gennaro, Francesco Di

Published
2022

7. Pooled analysis of the MANTICO2 and MONET randomized controlled trials comparing drug efficacy for early treatment of COVID-19 during Omicron waves

Author

Mazzotta, Valentina, Mazzaferri, Fulvia, Lanini, Simone, Mirandola, Massimo, Cozzi Lepri, Alessandro, Vergori, Alessandra, Savoldi, Alessia, Santoro, Andrea, Maccarrone, Gaia, Mastrorosa, Ilaria, Simonetti, Omar, Zottis, Federico De, Nicastri, Emanuele, Rosini, Giulia, Rovigo, Laura, Tavernaro, Lorenzo, Sarmati, Loredana, Tascini, Carlo, Girardi, Enrico, Cattelan, Anna Maria, Antinori, Andrea, and Tacconelli, Evelina

Published
2024
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9. Clinical and laboratory predictors of mpox severity and duration: an Italian multicentre cohort study (mpox-Icona)

Author

Antinori, Andrea, Antinori, Spinello, Baiguera, Chiara, Baldin, Gianmaria, Bassetti, Matteo, Biasioli, Lorenzo, Bonfanti, Paolo, Brucci, Giorgia, Bruzzesi, Elena, Candela, Caterina, Cascio, Antonio, Castagna, Antonella, Monforte, Antonella d'Arminio, Delama, Andrea, D'Ettorre, Gabriella, Farinacci, Damiano, Fusco, Francesco Maria, Gismondo, Maria Rita, Gori, Andrea, Lanini, Simone, Lanzafame, Massimiliano, Lapadula, Giuseppe, Lichtner, Miriam, Maci, Chiara, Mancarella, Giulia, Mancon, Alessandro, Marchetti, Giulia, Matusali, Giulia, Mazzotta, Valentina, Nicastri, Emanuele, Nozza, Silvia, Pandolfo, Alessandro, Panzo, Francesca, Piconi, Stefania, Pinnetti, Carmela, Pipitò, Luca, Raccagni, Angelo Roberto, Raimondi, Alessandro, Ridolfi, Marco, Rizzardini, Giuliano, Rodanò, Alessandra, Rossotti, Roberto, Sambo, Margherita, Sangiovanni, Vincenzo, Sangiovanni, Nadia, Tamburrini, Enrica, Tavelli, Alessandro, Tesoro, Daniele, Vita, Serena, Moschese, Davide, Mileto, Davide, Di Biagio, Antonio, and Monforte, Antonella d’Arminio

Published
2024
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14. Immunogenicity and reactogenicity of modified vaccinia Ankara pre-exposure vaccination against mpox according to previous smallpox vaccine exposure and HIV infection: prospective cohort study

Author

Anzalone, Enza, Camici, Marta, Cannone, Fabio, Caputi, Priscilla, Cimaglia, Claudia, Corso, Rita, Cristofanelli, Flavia, Cruciani, Stefania, De Marco, Nicola, De Ponte, Chiara, Del Duca, Giulia, Faccendini, Paolo, Faraglia, Francesca, Faticoni, Augusto, Fusto, Marisa, Gebremeskel, Saba, Giancola, Maria Letizia, Giannico, Giuseppina, Gili, Simona, Iannella, Maria Rosaria, Junea, Angela, Lamonaca, Alessandra, Marani, Alessandra, Masone, Erminia, Mastrorosa, Ilaria, Mazzotta, Stefania, Nappo, Alessandra, Natalini, Giorgia, Parisi, Alfredo, Passacantilli, Sara, Paulicelli, Jessica, Plazzi, Maria Maddalena, Possi, Adriano, Preziosi, Gianni, Rosati, Silvia, Rubino, Marika, Scanzano, Pietro, Scorzolini, Laura, Tomassi, Virginia, Vescovo, Maurizio, Vita, Serena, Caterini, Luciano, Coppola, Luigi, Kontogiannis, Dimitra, D'Ettorre, Gabriella, Ridolfi, Marco, Di Giambenedetto, Simona, Farinacci, Damiano, Latini, Alessandra, Marchili, Mauro, Marocco, Raffaella, Mazzotta, Valentina, Lepri, Alessandro Cozzi, Matusali, Giulia, Cimini, Eleonora, Piselli, Pierluca, Aguglia, Camilla, Lanini, Simone, Colavita, Francesca, Notari, Stefania, Oliva, Alessandra, Meschi, Silvia, Casetti, Rita, Mondillo, Vanessa, Vergori, Alessandra, Bettini, Aurora, Grassi, Germana, Pinnetti, Carmela, Lapa, Daniele, Tartaglia, Eleonora, Gallì, Paola, Mondi, Annalisa, Montagnari, Giulia, Gagliardini, Roberta, Nicastri, Emanuele, Lichtner, Miriam, Sarmati, Loredana, Tamburrini, Enrica, Mastroianni, Claudio, Stingone, Christof, Siddu, Andrea, Barca, Alessandra, Fontana, Carla, Agrati, Chiara, Girardi, Enrico, Vaia, Francesco, Maggi, Fabrizio, and Antinori, Andrea

Published
2024
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16. Compassionate Use of Remdesivir for Patients with Severe Covid-19

Author

Grein, Jonathan, Ohmagari, Norio, Shin, Daniel, Diaz, George, Asperges, Erika, Castagna, Antonella, Feldt, Torsten, Green, Gary, Green, Margaret L, Lescure, François-Xavier, Nicastri, Emanuele, Oda, Rentaro, Yo, Kikuo, Quiros-Roldan, Eugenia, Studemeister, Alex, Redinski, John, Ahmed, Seema, Bernett, Jorge, Chelliah, Daniel, Chen, Danny, Chihara, Shingo, Cohen, Stuart H, Cunningham, Jennifer, D'Arminio Monforte, Antonella, Ismail, Saad, Kato, Hideaki, Lapadula, Giuseppe, L'Her, Erwan, Maeno, Toshitaka, Majumder, Sumit, Massari, Marco, Mora-Rillo, Marta, Mutoh, Yoshikazu, Nguyen, Duc, Verweij, Ewa, Zoufaly, Alexander, Osinusi, Anu O, DeZure, Adam, Zhao, Yang, Zhong, Lijie, Chokkalingam, Anand, Elboudwarej, Emon, Telep, Laura, Timbs, Leighann, Henne, Ilana, Sellers, Scott, Cao, Huyen, Tan, Susanna K, Winterbourne, Lucinda, Desai, Polly, Mera, Robertino, Gaggar, Anuj, Myers, Robert P, Brainard, Diana M, Childs, Richard, and Flanigan, Timothy

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Emerging Infectious Diseases, Lung, Clinical Trials and Supportive Activities, Clinical Research, Prevention, Infectious Diseases, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Good Health and Well Being, Adenosine Monophosphate, Administration, Intravenous, Adult, Aged, Aged, 80 and over, Alanine, Antiviral Agents, Betacoronavirus, COVID-19, Canada, Compassionate Use Trials, Coronavirus Infections, Europe, Female, Humans, Japan, Male, Middle Aged, Pandemics, Pneumonia, Viral, Respiration, Artificial, SARS-CoV-2, United States, Young Adult, COVID-19 Drug Treatment, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundRemdesivir, a nucleotide analogue prodrug that inhibits viral RNA polymerases, has shown in vitro activity against SARS-CoV-2.MethodsWe provided remdesivir on a compassionate-use basis to patients hospitalized with Covid-19, the illness caused by infection with SARS-CoV-2. Patients were those with confirmed SARS-CoV-2 infection who had an oxygen saturation of 94% or less while they were breathing ambient air or who were receiving oxygen support. Patients received a 10-day course of remdesivir, consisting of 200 mg administered intravenously on day 1, followed by 100 mg daily for the remaining 9 days of treatment. This report is based on data from patients who received remdesivir during the period from January 25, 2020, through March 7, 2020, and have clinical data for at least 1 subsequent day.ResultsOf the 61 patients who received at least one dose of remdesivir, data from 8 could not be analyzed (including 7 patients with no post-treatment data and 1 with a dosing error). Of the 53 patients whose data were analyzed, 22 were in the United States, 22 in Europe or Canada, and 9 in Japan. At baseline, 30 patients (57%) were receiving mechanical ventilation and 4 (8%) were receiving extracorporeal membrane oxygenation. During a median follow-up of 18 days, 36 patients (68%) had an improvement in oxygen-support class, including 17 of 30 patients (57%) receiving mechanical ventilation who were extubated. A total of 25 patients (47%) were discharged, and 7 patients (13%) died; mortality was 18% (6 of 34) among patients receiving invasive ventilation and 5% (1 of 19) among those not receiving invasive ventilation.ConclusionsIn this cohort of patients hospitalized for severe Covid-19 who were treated with compassionate-use remdesivir, clinical improvement was observed in 36 of 53 patients (68%). Measurement of efficacy will require ongoing randomized, placebo-controlled trials of remdesivir therapy. (Funded by Gilead Sciences.).

Published
2020

17. Kinetics of viral DNA in body fluids and antibody response in patients with acute Monkeypox virus infection

Author

Colavita, Francesca, Mazzotta, Valentina, Rozera, Gabriella, Abbate, Isabella, Carletti, Fabrizio, Pinnetti, Carmela, Matusali, Giulia, Meschi, Silvia, Mondi, Annalisa, Lapa, Daniele, Vita, Serena, Minosse, Claudia, Aguglia, Camilla, Gagliardini, Roberta, Specchiarello, Eliana, Bettini, Aurora, Nicastri, Emanuele, Girardi, Enrico, Vaia, Francesco, Antinori, Andrea, and Maggi, Fabrizio

Published
2023
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18. Sarilumab plus standard of care vs standard of care for the treatment of severe COVID-19: a phase 3, randomized, open-labeled, multi-center study (ESCAPE study)

Author

Agrati, Chiara, Andreoni, Massimo, Antinori, Andrea, Bai, Francesca, Beccacece, Alessia, Barreca, Filippo, Bertuccio, Maria Paola, Bini, Teresa, Boumis, Evangelo, Camici, Marta, Cauda, Roberto, Cerva, Carlotta, Cicalini, Stefania, Cingolani, Antonella, D'Arminio Monforte, Antonella, D'Urso, Angela, De Masi, Margherita, De Zottis, Federico, Del Borgo, Cosmo, Di Gennaro, Francesco, Emiliozzi, Arianna, Fantoni, Massimo, Fondaco, Laura, Fusto, Marisa, Gagliardini, Roberta, Giovannenze, Francesca, Grilli, Elisabetta, Iannetta, Marco, Iodice, Daniele, Lichtner, Miriam, Lorenzini, Patrizia, Maffongelli, Gaetano, Masone, Erminia, Massa, Barbara, Mastrorosa, Ilaria, Mazzotta, Valentina, Mencarini, Paola, Milozzi, Eugenia, Mondi, Annalisa, Mosti, Silvia, Murri, Rita, Negri, Marcantonio, Nicastri, Emanuele, Oliva, Gian Piero, Onnelli, Giovanna, Ottou, Sandrine, Pace, Pier Giorgio, Palmieri, Fabrizio, Paulicelli, Jessica, Pinnetti, Carmela, Plazzi, Maria Maddalena, Sarmati, Loredana, Segala, Francesco Vladimiro, Sorace, Chiara, Taddei, Eleonora, Vergori, Alessandra, Vitale, Pietro, Lamonica, Silvia, Girardi, Enrico, and Vaia, Francesco

Published
2023
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19. Immunological signature in human cases of monkeypox infection in 2022 outbreak: an observational study

Author

Agrati, Chiara, Cossarizza, Andrea, Mazzotta, Valentina, Grassi, Germana, Casetti, Rita, De Biasi, Sara, Pinnetti, Carmela, Gili, Simona, Mondi, Annalisa, Cristofanelli, Flavia, Lo Tartaro, Domenico, Notari, Stefania, Maffongelli, Gaetano, Gagliardini, Roberta, Gibellini, Lara, Aguglia, Camilla, Lanini, Simone, D'Abramo, Alessandra, Matusali, Giulia, Fontana, Carla, Nicastri, Emanuele, Maggi, Fabrizio, Girardi, Enrico, Vaia, Francesco, and Antinori, Andrea

Published
2023
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21. Efficacy and safety of early soluble urokinase plasminogen receptor plasma-guided anakinra treatment of COVID-19 pneumonia: a subgroup analysis of the SAVE-MORE randomised trial

Author

Akinosoglou, Karolina, Kotsaki, Antigone, Gounaridi, Ioanna-Maria, Christaki, Eirini, Metallidis, Simeon, Adamis, Georgios, Fragkou, Archontoula, Fantoni, Massimo, Rapti, Aggeliki, Kalomenidis, Ioannis, Chrysos, Georgios, Boni, Gloria, Kainis, Ilias, Alexiou, Zoi, Castelli, Francesco, Serino, Francesco Saverio, Bakakos, Petros, Nicastri, Emanuele, Tzavara, Vassiliki, Safarika, Asimina, Ioannou, Sofia, Dagna, Lorenzo, Dimakou, Katerina, Tzatzagou, Glykeria, Chini, Maria, Bassetti, Matteo, Kotsis, Vasileios, Angheben, Andrea, Tsoukalas, George, Selmi, Carlo, Spiropoulou, Olga-Maria, Samarkos, Michael, Doumas, Michael, Damoraki, Georgia, Masgala, Aikaterini, Papanikolaou, Ilias, Argyraki, Aikaterini, Negri, Marcantonio, Leventogiannis, Konstantinos, Sympardi, Styliani, Gatselis, Nikolaos K., Petrakis, Vasileios, Netea, Mihai G., Panagopoulos, Periklis, Sakka, Vissaria, Milionis, Haralampos, Dalekos, George N., and Giamarellos-Bourboulis, Evangelos J.

Published
2023
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22. Real-life comparison of mortality in patients with SARS-CoV-2 infection at risk for clinical progression treated with molnupiravir or nirmatrelvir plus ritonavir during the Omicron era in Italy: a nationwide, cohort study

Author

Torti, Carlo, Olimpieri, Pier Paolo, Bonfanti, Paolo, Tascini, Carlo, Celant, Simone, Tacconi, Danilo, Nicastri, Emanuele, Tacconelli, Evelina, Cacopardo, Bruno, Perrella, Alessandro, Buccoliero, Giovanni Battista, Parruti, Giustino, Bassetti, Matteo, Biagetti, Carlo, Giacometti, Andrea, Erne, Elke Maria, Frontuto, Maria, Lanzafame, Massimiliano, Summa, Valentina, Spagnoli, Alessandra, Vestri, Annarita, Di Perri, Giovanni, Russo, Pierluigi, and Palù, Giorgio

Published
2023
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23. Evaluation of the Local and Peripheral Immune Responses in Patients with Cystic Echinococcosis

Author

Petrone, Linda, primary, Najafi-Fard, Saeid, additional, Falasca, Laura, additional, Sbarra, Settimia, additional, Teggi, Antonella, additional, Nicastri, Emanuele, additional, Grillo, Lucia Rosalba, additional, Burocchi, Mirco, additional, Ettorre, Giuseppe Maria, additional, Ludovisi, Alessandra, additional, Colombo, Daniele, additional, Del Nonno, Franca, additional, and Goletti, Delia, additional

Published
2024
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24. SARS-CoV-2 nasopharyngeal viral load in individuals infected with BA.2, compared to Alpha, Gamma, Delta and BA.1 variants: A single-center comparative analysis

Author

Mastrorosa, Ilaria, Cozzi-Lepri, Alessandro, Colavita, Francesca, Lalle, Eleonora, Mazzotta, Valentina, Cimaglia, Claudia, Paulicelli, Jessica, Matusali, Giulia, Fabeni, Lavinia, Carletti, Fabrizio, Rosati, Silvia, Vita, Serena, Giannico, Giuseppina, Piselli, Pierluca, Biliotti, Elisa, Moghazi, Samir Al, Mosti, Silvia, Girardi, Enrico, Nicastri, Emanuele, Garbuglia, Anna Rosa, Maggi, Fabrizio, Vaia, Francesco, and Antinori, Andrea

Published
2022
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25. Booster dose of SARS-CoV-2 messenger RNA vaccines strengthens the specific immune response of patients with rheumatoid arthritis: A prospective multicenter longitudinal study

Author

Farroni, Chiara, Aiello, Alessandra, Picchianti-Diamanti, Andrea, Laganà, Bruno, Petruccioli, Elisa, Agrati, Chiara, Garbuglia, Anna Rosa, Meschi, Silvia, Lapa, Daniele, Cuzzi, Gilda, Petrone, Linda, Vanini, Valentina, Salmi, Andrea, Altera, Anna Maria Gerarda, Repele, Federica, Grassi, Germana, Bettini, Aurora, Vita, Serena, Mariano, Andrea, Damiani, Arianna, Infantino, Maria, Grossi, Valentina, Manfredi, Mariangela, Niccoli, Laura, Puro, Vincenzo, Rosa, Roberta Di, Salemi, Simonetta, Sesti, Giorgio, Scolieri, Palma, Bruzzese, Vincenzo, Benucci, Maurizio, Cantini, Fabrizio, Nicastri, Emanuele, and Goletti, Delia

Published
2022
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27. The unmet need for COVID-19 treatment in immunocompromised patients

Author

D’Abramo Alessandra, Vita Serena, and Nicastri Emanuele

Subjects
Immunocompromised patients, Severe and/or prolonged COVID-19, Passive immunotherapy, Antiviral therapy, Combined therapy, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Immunocompromised (IC) patients are at increased risk of severe and/or prolonged COVID-19. Main text The recent study by Scaglione et al., addresses the issue of IC outpatients with SARS-CoV-2 infection. Authors describe the real-life use of SARS-CoV-2 antivirals and/or monoclonal antibodies and the clinical benefit in high-risk COVID-19 patients. The study supports the use of early combination therapy in a subgroup of extremely high risk patients, and considers the combined strategy as a gold standard regimen to both increase the effectiveness of early treatment, especially in IC individuals, and, reduce the emergence of SARS-CoV-2 escape mutants. Conclusion A tailored and standardised therapeutic approach in case of IC out and inpatients with SARS-CoV-2 infection is needed.

Published
2022
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28. Accuracy of QuantiFERON SARS-CoV-2 research use only assay and characterization of the CD4+ and CD8+ T cell-SARS-CoV-2 response: comparison with a homemade interferon-γ release assay

Author

Aiello, Alessandra, Coppola, Andrea, Vanini, Valentina, Petrone, Linda, Cuzzi, Gilda, Salmi, Andrea, Altera, Anna Maria Gerarda, Tortorella, Carla, Gualano, Gina, Gasperini, Claudio, Scolieri, Palma, Beccacece, Alessia, Vita, Serena, Bruzzese, Vincenzo, Lorenzetti, Roberto, Palmieri, Fabrizio, Nicastri, Emanuele, and Goletti, Delia

Published
2022
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29. Autochthonous Dengue Fever in 2 Patients, Rome, Italy

Author

Vita, Serena, Bordi, Licia, Sberna, Giuseppe, Caputi, Priscilla, Lapa, Daniele, Corpolongo, Angela, Mija, Cosmina, D'Abramo, Alessandra, Maggi, Fabrizio, Vairo, Francesco, Specchiarello, Eliana, Girardi, Enrico, Lalle, Eleonora, and Nicastri, Emanuele

Subjects
Aedes albopictus -- Health aspects, Dengue -- Health aspects, Infection -- Health aspects, Travelers -- Health aspects, Disease transmission -- Health aspects, Health
Abstract

Dengue virus (DENV) infection is the most prevalent arthropodborne viral disease in humans, caused by 4 DENV serotypes widely spread in tropical and subtropical regions and transmitted mainly by Aedes [...]

Published
2024

30. Infectious Toscana Virus in Seminal Fluid of Young Man Returning from Elba Island, Italy

Author

Matusali, Giulia, D'Abramo, Alessandra, Terrosi, Chiara, Carletti, Fabrizio, Colavita, Francesca, Vairo, Francesco, Savellini, Gianni Gori, Gandolfo, Claudia, Anichini, Gabriele, Lalle, Eleonora, Bordi, Licia, Corpolongo, Angela, Maritti, Micaela, Marchioni, Luisa, Capobianchi, Maria Rosaria, Castilletti, Concetta, Cusi, Maria Grazia, and Nicastri, Emanuele

Subjects
Semen -- Case studies -- Health aspects, Bunyaviruses -- Case studies -- Identification and classification, RNA virus infections -- Case studies -- Risk factors -- Diagnosis, Viral meningitis -- Case studies -- Risk factors -- Diagnosis, Health
Abstract

Toscana virus (TOSV) is an arthropodborne virus, belonging to the genus Phlebovirus, that was first isolated in Monte Argentario in 1971 from the sand flies Phlebotomus perniciosus and P. perfiliewi [...]

Published
2022
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32. A phase 2 randomized, double-blinded, placebo-controlled, multicenter trial evaluating the efficacy and safety of raloxifene for patients with mild to moderate COVID-19

Author

Nicastri, Emanuele, Marinangeli, Franco, Pivetta, Emanuele, Torri, Elena, Reggiani, Francesco, Fiorentino, Giuseppe, Scorzolini, Laura, Vettori, Serena, Marsiglia, Carolina, Gavioli, Elizabeth Marie, Beccari, Andrea R., Terpolilli, Giuseppe, De Pizzol, Maria, Goisis, Giovanni, Mantelli, Flavio, Vaia, Francesco, and Allegretti, Marcello

Published
2022
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33. Safety and immune response kinetics of GRAd-COV2 vaccine: phase 1 clinical trial results

Author

Agrati, Chiara, Castilletti, Concetta, Battella, Simone, Cimini, Eleonora, Matusali, Giulia, Sommella, Andrea, Sacchi, Alessandra, Colavita, Francesca, Contino, Alessandra M., Bordoni, Veronica, Meschi, Silvia, Gramigna, Giulia, Barra, Federica, Grassi, Germana, Bordi, Licia, Lapa, Daniele, Notari, Stefania, Casetti, Rita, Bettini, Aurora, Francalancia, Massimo, Ciufoli, Federica, Vergori, Alessandra, Vita, Serena, Gentile, Michela, Raggioli, Angelo, Plazzi, Maria M., Bacchieri, Antonella, Nicastri, Emanuele, Antinori, Andrea, Milleri, Stefano, Lanini, Simone, Colloca, Stefano, Girardi, Enrico, Camerini, Roberto, Ippolito, Giuseppe, Vaia, Francesco, Folgori, Antonella, and Capone, Stefania

Published
2022
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35. Epidemiology of ventilator-associated pneumonia in ICU COVID-19 patients: an alarming high rate of multidrug-resistant bacteria

Author

Tetaj, Nardi, Capone, Alessandro, Stazi, Giulia Valeria, Marini, Maria Cristina, Garotto, Gabriele, Busso, Donatella, Scarcia, Silvana, Caravella, Ilaria, Macchione, Manuela, De Angelis, Giada, Di Lorenzo, Rachele, Carucci, Alessandro, Antonica, Maria Vittoria, Gaviano, Ilaria, Inversi, Carlo, Agostini, Elisabetta, Canichella, Flaminia, Taloni, Giorgia, Evangelista, Francesca, Onnis, Ilaria, Mogavero, Giulia, Lamanna, Maria Elena, Rubino, Dorotea, Di Frischia, Mattia, Porcelli, Candido, Cesi, Elena, Antinori, Andrea, Palmieri, Fabrizio, D’Offizi, Gianpiero, Taglietti, Fabrizio, Nisii, Carla, Cataldo, Maria Adriana, Ianniello, Stefania, Campioni, Paolo, Vaia, Francesco, Nicastri, Emanuele, Girardi, Enrico, and Marchioni, Luisa

Published
2022
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36. Proteomic analysis identifies a signature of disease severity in the plasma of COVID-19 pneumonia patients associated to neutrophil, platelet and complement activation

Author

Ciccosanti, Fabiola, Antonioli, Manuela, Sacchi, Alessandra, Notari, Stefania, Farina, Anna, Beccacece, Alessia, Fusto, Marisa, Vergori, Alessandra, D’Offizi, Gianpiero, Taglietti, Fabrizio, Antinori, Andrea, Nicastri, Emanuele, Marchioni, Luisa, Palmieri, Fabrizio, Ippolito, Giuseppe, Piacentini, Mauro, Agrati, Chiara, and Fimia, Gian Maria

Published
2022
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37. Safety and serum distribution of anti-SARS-CoV-2 monoclonal antibody MAD0004J08 after intramuscular injection

Author

Lanini, Simone, Milleri, Stefano, Andreano, Emanuele, Nosari, Sarah, Paciello, Ida, Piccini, Giulia, Gentili, Alessandra, Phogat, Adhuna, Hyseni, Inesa, Leonardi, Margherita, Torelli, Alessandro, Montomoli, Emanuele, Paolini, Andrea, Frosini, Andrea, Antinori, Andrea, Nicastri, Emanuele, Girardi, Enrico, Plazzi, Maria Maddalena, Ippolito, Giuseppe, Vaia, Francesco, Della Cioppa, Giovanni, and Rappuoli, Rino

Published
2022
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39. Immunomodulatory effects of cysteamine and its potential use as a host-directed therapy for tuberculosis.

Author

Najafi-Fard, Saeid, Farroni, Chiara, Petrone, Linda, Altera, Anna Maria Gerarda, Salmi, Andrea, Vanini, Valentina, Cuzzi, Gilda, Alonzi, Tonino, Nicastri, Emanuele, Gualano, Gina, Palmieri, Fabrizio, Piacentini, Mauro, and Goletti, Delia

Subjects
MONONUCLEAR leukocytes, TH1 cells, NECROSIS, CYSTEAMINE, FLOW cytometry, CELL survival
Abstract

Objective: Cysteamine, a drug approved to treat cystinosis, has been proposed as a host-directed therapy for M. tuberculosis (Mtb) and SARS-CoV-2. The impact of cysteamine on the immune responses has not been fully investigated. We aimed to in vitro evaluate the immunomodulatory effects of cysteamine on peripheral blood mononuclear cells (PBMCs) using the purified protein derivative (PPD) as a recall antigen, and an unspecific stimulus as staphylococcal enterotoxin B (SEB). Methods: PBMCs isolated from subjects with tuberculosis infection (TBI), those with tuberculosis disease (TB), and healthy controls (HC) were in vitro stimulated with PPD or SEB and treated or not with cysteamine at different concentrations (50 µM–400 µM) for 6 hours (h) and 24 h. We evaluated the T helper1 (Th1) and T cytotoxic1 (Tc1) cell cytokine production by flow cytometry and immune-enzymatic assays. In HC, we also evaluated apoptosis and/or necrosis by flow cytometry. Results: We observed an immunomodulatory effect of cysteamine at 400 µM in PBMCs from TB and TBI subjects. It significantly reduced PPD-specific Th1 responses at 24 h and at 6 h (p=0.0004 and p=0.0009, respectively), and a similar non-significant trend was observed with cysteamine at 200 µM (p=0.06 at 24 h and p=0.14 at 6 h). Moreover, cysteamine at both 400 µM (p<0.0001 and p=0.0187 at 24 h, respectively, and p<0.0001 at 6 h for both) and 200 µM (p=0.0119 and p=0.0028 at 24 h and p=0.0028 and p=0.0003 at 6 h, respectively) significantly reduced SEB-induced Th1 and Tc1 responses. Furthermore, we found that cysteamine induced morphological lymphocyte changes and significantly reduced the lymphocyte percentage in a dose- and time-dependent manner. Cysteamine at 400 µM induced 8% late apoptosis and 1.6% necrosis (p<0.05) at 24 h. In contrast, despite significant differences from untreated conditions (p<0.05), cysteamine at 400 µM for 6 h induced approximately 1% late apoptosis and 0.1% necrosis in the cells. Conclusions: High doses of cysteamine in vitro reduce the percentages of PPD- and SEB-induced Th1 and Tc1 cells and induce late apoptosis and necrosis. Differently, cysteamine at lower doses retains the immunomodulatory effect without affecting cell viability. These findings suggest cysteamine as a potential adjunct to antimicrobial regimens as in the TB or COVID-19 field, for its ability to reduce the inflammatory status. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Characterization of the Monkeypox Virus [MPX]-Specific Immune Response in MPX-Cured Individuals Using Whole Blood to Monitor Memory Response.

Author

Petruccioli, Elisa, Sbarra, Settimia, Vita, Serena, Salmi, Andrea, Cuzzi, Gilda, De Marco, Patrizia, Matusali, Giulia, Navarra, Assunta, Pierelli, Luca, Grifoni, Alba, Sette, Alessandro, Maggi, Fabrizio, Nicastri, Emanuele, and Goletti, Delia

Subjects
ZOONOSES, MONKEYPOX, VACCINATION status, SMALLPOX vaccines, VACCINIA
Abstract

Background: Monkeypox (Mpox) is a zoonotic disease caused by monkeypox virus (MPXV), an Orthopoxvirus (OPXV). Since we are observing the first MPXV outbreak outside the African continent, the general population probably does not have a pre-existing memory response for MPXV but may have immunity against the previous smallpox vaccine based on a live replicating Vaccinia strain (VACV). Using a whole blood platform, we aim to study the MPXV- T-cell-specific response in Mpox-cured subjects. Methods: We enrolled 16 subjects diagnosed with Mpox in the previous 3–7 months and 15 healthy donors (HD) with no recent vaccination history. Whole blood was stimulated overnight with MPXV and VACV peptides to elicit CD4 and CD8 T-cell-specific responses, which were evaluated by ELISA and multiplex assay. Results: Mpox-cured subjects showed a significant IFN-γ T-cell response to MPXV and VACV. Besides IFN-γ, IL-6, IP-10, IL-8, IL-2, G-CSF, MCP-1, MIP1-α, MIP-1β, IL-1Rα, and IL-5 were significantly induced after specific stimulation compared to the unstimulated control. The specific response was mainly induced by the CD4 peptides MPX-CD4-E and VACV-CD4. Conclusions: We showed that MPXV-specific responses have a mixed Th1- and Th2-response in a whole blood platform assay, which may be useful for monitoring the specific immunity induced by vaccination or infection. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Predictors of Mortality and Orotracheal Intubation in Patients with Pulmonary Barotrauma Due to COVID-19: An Italian Multicenter Observational Study during Two Years of the Pandemic

Author

Tetaj, Nardi, primary, De Pascale, Gennaro, additional, Antonelli, Massimo, additional, Vargas, Joel, additional, Savino, Martina, additional, Pugliese, Francesco, additional, Alessandri, Francesco, additional, Giordano, Giovanni, additional, Tozzi, Pierfrancesco, additional, Rocco, Monica, additional, Biava, Anna Maria, additional, Maggi, Luigi, additional, Pisapia, Raffaella, additional, Fusco, Francesco Maria, additional, Stazi, Giulia Valeria, additional, Garotto, Gabriele, additional, Marini, Maria Cristina, additional, Piselli, Pierluca, additional, Beccacece, Alessia, additional, Mariano, Andrea, additional, Giancola, Maria Letizia, additional, Ianniello, Stefania, additional, Vaia, Francesco, additional, Girardi, Enrico, additional, Antinori, Andrea, additional, Bocci, Maria Grazia, additional, Marchioni, Luisa, additional, and Nicastri, Emanuele, additional

Published
2024
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44. Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis

Author

Kyriazopoulou, Evdoxia, Huet, Thomas, Cavalli, Giulio, Gori, Andrea, Kyprianou, Miltiades, Pickkers, Peter, Eugen-Olsen, Jesper, Clerici, Mario, Veas, Francisco, Chatellier, Gilles, Kaplanski, Gilles, Netea, Mihai G., Pontali, Emanuele, Gattorno, Marco, Cauchois, Raphael, Kooistra, Emma, Kox, Matthijs, Bandera, Alessandra, Beaussier, Hélène, Mangioni, Davide, Dagna, Lorenzo, van der Meer, Jos W.M., Giamarellos-Bourboulis, Evangelos J., Hayem, Gilles, Volpi, Stefano, Sormani, Maria Pia, Signori, Alessio, Bozzi, Giorgio, Minoia, Francesca, Aliberti, Stefano, Grasselli, Giacomo, Alagna, Laura, Lombardi, Andrea, Ungaro, Riccardo, Agostoni, Carlo, Blasi, Francesco, Costantino, Giorgio, Fracanzani, Anna Ludovica, Montano, Nicola, Peyvandi, Flora, Sottocorno, Marcello, Muscatello, Antonio, Filocamo, Giovanni, Papadopoulos, Antonios, Mouktaroudi, Maria, Karakike, Eleni, Saridaki, Maria, Gkavogianni, Theologia, Katrini, Konstantina, Vechlidis, Nikolaos, Avgoustou, Christina, Chalvatzis, Stamatios, Marantos, Theodoros, Damoulari, Christina, Damoraki, Georgia, Ktena, Sofia, Tsilika, Maria, Koufargyris, Panagiotis, Karageorgos, Athanasios, Droggiti, Dionysia-Irene, Koliakou, Aikaterini, Poulakou, Garyfallia, Tsiakos, Konstantinos, Myrodia, Dimitra-Melia, Gravvani, Areti, Trontzas, Ioannis P., Syrigos, Konstantinos, Kalomenidis, Ioannis, Kranidioti, Eleftheria, Panagopoulos, Periklis, Petrakis, Vasileios, Metallidis, Simeon, Loli, Georgia, Tsachouridou, Olga, Dalekos, George N., Gatselis, Nikolaos, Stefos, Aggelos, Georgiadou, Sarah, Lygoura, Vassiliki, Milionis, Haralampos, Kosmidou, Maria, Papanikolaou, Ilias C., Akinosoglou, Karolina, Giannitsioti, Efthymia, Chrysos, Georgios, Mavroudis, Panagiotis, Sidiropoulou, Chrysanthi, Adamis, Georgios, Fragkou, Archontoula, Rapti, Aggeliki, Alexiou, Zoi, Symbardi, Styliani, Masgala, Aikaterini, Kostaki, Konstantina, Kostis, Evangelos, Samarkos, Michael, Bakakos, Petros, Tzavara, Vassiliki, Dimakou, Katerina, Tzatzagou, Glykeria, Chini, Maria, Kotsis, Vasileios, Tsoukalas, George, Bliziotis, Ioannis, Doumas, Michael, Argyraki, Aikaterini, Kainis, Ilias, Fantoni, Massimo, Cingolani, Antonella, Angheben, Andrea, Cardellino, Chiara Simona, Castelli, Francesco, Serino, Francesco Saverio, Nicastri, Emanuele, Ippolito, Giuseppe, Bassetti, Matteo, Selmi, Carlo, Netea, Mihai G, van der Meer, Jos W M, and Giamarellos-Bourboulis, Evangelos J

Published
2021
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45. Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

Author

Kyriazopoulou, Evdoxia, Poulakou, Garyfallia, Milionis, Haralampos, Metallidis, Simeon, Adamis, Georgios, Tsiakos, Konstantinos, Fragkou, Archontoula, Rapti, Aggeliki, Damoulari, Christina, Fantoni, Massimo, Kalomenidis, Ioannis, Chrysos, Georgios, Angheben, Andrea, Kainis, Ilias, Alexiou, Zoi, Castelli, Francesco, Serino, Francesco Saverio, Tsilika, Maria, Bakakos, Petros, Nicastri, Emanuele, Tzavara, Vassiliki, Kostis, Evangelos, Dagna, Lorenzo, Koufargyris, Panagiotis, Dimakou, Katerina, Savvanis, Spyridon, Tzatzagou, Glykeria, Chini, Maria, Cavalli, Giulio, Bassetti, Matteo, Katrini, Konstantina, Kotsis, Vasileios, Tsoukalas, George, Selmi, Carlo, Bliziotis, Ioannis, Samarkos, Michael, Doumas, Michael, Ktena, Sofia, Masgala, Aikaterini, Papanikolaou, Ilias, Kosmidou, Maria, Myrodia, Dimitra-Melia, Argyraki, Aikaterini, Cardellino, Chiara Simona, Koliakou, Katerina, Katsigianni, Eleni-Ioanna, Rapti, Vassiliki, Giannitsioti, Efthymia, Cingolani, Antonella, Micha, Styliani, Akinosoglou, Karolina, Liatsis-Douvitsas, Orestis, Symbardi, Styliani, Gatselis, Nikolaos, Mouktaroudi, Maria, Ippolito, Giuseppe, Florou, Eleni, Kotsaki, Antigone, Netea, Mihai G., Eugen-Olsen, Jesper, Kyprianou, Miltiades, Panagopoulos, Periklis, Dalekos, George N., and Giamarellos-Bourboulis, Evangelos J.

Published
2021
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46. Role of testosterone in SARS-CoV-2 infection: A key pathogenic factor and a biomarker for severe pneumonia

Author

Camici, Marta, Zuppi, Paolo, Lorenzini, Patrizia, Scarnecchia, Liliana, Pinnetti, Carmela, Cicalini, Stefania, Nicastri, Emanuele, Petrosillo, Nicola, Palmieri, Fabrizio, D’Offizi, Gianpiero, Marchioni, Luisa, Gagliardini, Roberta, Baldelli, Roberto, Schininà, Vincenzo, Pianura, Elisa, Di Stefano, Federica, Curcio, Stefano, Ciavarella, Lucia, Ippolito, Giuseppe, Girardi, Enrico, Vaia, Francesco, and Antinori, Andrea

Published
2021
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48. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Abbonizio, Maria Alessandra, Abdeddaim, Amina, Agostini, Elisabetta, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonica, Maria Assunta, Antonini, Mario, Bartoli, Tommaso Ascoli, Baldini, Francesco, Barbaro, Raffaella, Bartolini, Barbara, Bellagamba, Rita, Benigni, Martina, Bevilacqua, Nazario, Biava, Gianluigi, Bibas, Michele, Bordi, Licia, Bordoni, Veronica, Boumis, Evangelo, Branca, Marta, Buonomo, Rosanna, Busso, Donatella, Camici, Marta, Campioni, Paolo, Canichella, Flaminia, Capobianchi, Maria Rosaria, Capone, Alessandro, Caporale, Cinzia, Caraffa, Emanuela, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Cataldo, Adriana, Cerilli, Stefano, Cerva, Carlotta, Chiappini, Roberta, Chinello, Pierangelo, Cianfarani, Maria Assunta, Ciaralli, Carmine, Cimaglia, Claudia, Cinicola, Nicola, Ciotti, Veronica, Cicalini, Stefania, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, De Palo, Maria Grazia, De Zottis, Federico, Di Bari, Virginia, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Donno, Davide, Evangelista, Francesca, Faraglia, Francesca, Farina, Anna, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Fusetti, Matteo, Galati, Vincenzo, Gagliardini, Roberta, Gallì, Paola, Garotto, Gabriele, Gaviano, Ilaria, Tekle, Saba Gebremeskel, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Granata, Guido, Greci, Maria Cristina, Grilli, Elisabetta, Grisetti, Susanna, Gualano, Gina, Iacomi, Fabio, Iaconi, Marta, Iannicelli, Giuseppina, Inversi, Carlo, Ippolito, Giuseppe, Lalle, Eleonora, Lamanna, Maria Elena, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Libertone, Raffaella, Lionetti, Raffaella, Liuzzi, Giuseppina, Loiacono, Laura, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Maffongelli, Gaetano, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Mastrobattista, Annelisa, Mastrorosa, Ilaria, Matusali, Giulia, Mazzotta, Valentina, Mencarini, Paola, Meschi, Silvia, Messina, Francesco, Micarelli, Sibiana, Mogavero, Giulia, Mondi, Annalisa, Montalbano, Marzia, Montaldo, Chiara, Mosti, Silvia, Murachelli, Silvia, Musso, Maria, Nardi, Michela, Navarra, Assunta, Nicastri, Emanuele, Nocioni, Martina, Noto, Pasquale, Noto, Roberto, Oliva, Alessandra, Onnis, Ilaria, Ottou, Sandrine, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Palombi, Giulio, Pareo, Carlo, Passeri, Virgilio, Pelliccioni, Federico, Penna, Giovanna, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pinnetti, Carmela, Pisciotta, Maria, Piselli, Pierluca, Pittalis, Silvia, Pontarelli, Agostina, Proietti, Costanza, Puro, Vincenzo, Ramazzini, Paolo Migliorisi, Rianda, Alessia, Rinonapoli, Gabriele, Rosati, Silvia, Rubino, Dorotea, Rueca, Martina, Ruggeri, Alberto, Sacchi, Alessandra, Sampaolesi, Alessandro, Sanasi, Francesco, Santagata, Carmen, Scarabello, Alessandra, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Strano, Giacomo, Taglietti, Fabrizio, Taibi, Chiara, Taloni, Giorgia, Nardi, Tetaj, Tonnarini, Roberto, Topino, Simone, Tozzi, Martina, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Vergori, Alessandra, Vincenzi, Laura, Visco-Comandini, Ubaldo, Vita, Serena, Vittozzi, Pietro, Zaccarelli, Mauro, Zanetti, Antonella, Zito, Sara, Lorenzini, Patrizia, Di Gennaro, Francesco, and Girardi, Enrico

Published
2021
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