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272 results on '"Nicaise, C."'

8. Inflammatory bowel disease: profile of soluble cytokine receptors in Crohn's disease

Author

Gustot, T., Lemmers, A., Louis, E., Nicaise, C., Quertinmont, E., Belaiche, J., Roland, S., Van Gossum, A., Deviere, J., and Franchimont, D.

Subjects
Infliximab -- Drug therapy, Infliximab -- Patient outcomes, Cytokine receptors -- Research, Crohn's disease -- Development and progression, Crohn's disease -- Drug therapy, Corticosteroids -- Drug therapy, Corticosteroids -- Patient outcomes, Health
Published
2005

24. Circulating antibodies to nitrosylated proteins : a biomarker for familial amyotrophic lateral sclerosis. Study on the hSOD1 transgenic rat model

Author

Nicaise, C., Boom, A., Van Der Velden, C., Dabadie, M.P., Geffard, M., Pochet, R., Laboratoire de physique des interactions ondes matières (LPIOM), Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'intégration, du matériau au système (IMS), and Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, [SDV.TOX]Life Sciences [q-bio]/Toxicology
Abstract

Background Multifactorial processes have been proposed to contribute to amyotrophic lateral sclerosis (ALS), as oxidative stress through acquisition of toxic properties of the mutant superoxide dismutase 1 (SOD1). Recently, a role for oxidative damage on proteins has been proposed based on the enhanced production of free and bound nitrotyrosine in the cerebrospinal fluid of ALS human patients and murine models. Other biomarkers, as oxidative products in the blood including nitrosylated proteins or epitopes, could be useful in the diagnosis of ALS. Aim We investigated the presence of circulating antibodies directed against nitrosylated amino acids on plasmatic proteins as biological indicators of nitric oxide (NO) production and ALS disease progression. Methods We used hSOD1 (G93A) transgenic rats from Taconic and the age- and gender- matched wild-type littermates as controls. Rats were weighted every day and a clinical score was measured. Plasma was obtained on 10% citrated tube by tail venipunction. Enzyme-linked immunosorbent assays were performed on the blood samples to assay circulating antibodies directed to NO-Asparagine, NO-Methionine, NO-Histidine, NO-Tyrosin, NO-Arginine, NO-Phenylalanine and NO-Tryptophan. Results In ALS rat plasma, we have found higher levels of some antibodies directed against nitrosylated amino acids compared to control rat: NO-Asparagine (0, 158±0, 008 versus 0, 120±0, 011 units of Optical Density, p

Published
2006

25. Plasma circulating antibodies to nitrosylated proteins : a biomarker for familial Amyotrophic Lateral Sclerosis (ALS) ? Study on the hSOD1 transgenic rat model

Author

Nicaise, C., De Decker, R., Boom, A., Geffard, M., Pochet, R., Laboratoire de physique des interactions ondes matières (LPIOM), Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'intégration, du matériau au système (IMS), and Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, [SDV.TOX]Life Sciences [q-bio]/Toxicology
Published
2006

26. Amyotrophic Lateral Sclerosis : pre-clinical study on rat model using GEMALS drug with beneficial effects

Author

Nicaise, C., De Decker, R., Coupier, J., Bodet, D., Geffard, M., Poncelet, L., Pochet, R., Laboratoire de physique des interactions ondes matières (LPIOM), Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'intégration, du matériau au système (IMS), and Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, [SDV.TOX]Life Sciences [q-bio]/Toxicology
Published
2006

28. Clinical features and neuroradiological findings of mitochondrial pathology in six neonates

Author

Nadine Girard, Dejode Jm, Einaudi Ma, Nicaise C, Catherine Gire, and Montfort Mf

Subjects
Male, Pathology, medicine.medical_specialty, Mitochondrial Diseases, Mitochondrial disease, Respiratory chain, Cardiomyopathy, Hypoxic Ischemic Encephalopathy, White matter, Multienzyme Complexes, medicine, Humans, Muscle, Skeletal, Cerebral atrophy, Arthrogryposis, medicine.diagnostic_test, business.industry, Infant, Newborn, Brain, Magnetic resonance imaging, General Medicine, medicine.disease, Magnetic Resonance Imaging, Mitochondria, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, Female, Neurology (clinical), medicine.symptom, business
Abstract

Objects. We hoped to itemize the clinical and neuroradiological features of six neonates with mitochondrial disorders. Methods. We examined a case series of six neonates. The diagnosis of mitochondrial cytopathy was made on the basis of spectrophotometric measurements of respiratory chain enzyme activities in skeletal muscle biopsy specimens. Magnetic resonance (MR) imaging was performed in all cases. Conclusions. The antenatal onset in five cases and the lack of any symptom-free interval are suggestive of fetal expression of the disease. No specific symptoms were found: arthrogryposis congenita multiplex in one, progressive hepatocellular dysfunction in three, encephalomyelopathy and cardiomyopathy in four. Complex I deficiency was found in three patients, while one patients had a defect of complex IV and the last a combined defect of complexes I and IV. Neuroradiological findings were either cerebral atrophy or white matter abnormalities of the brain stem in all cases but one and gave additional information, because clinical symptoms are not quite specific. The combination of clinical and MRI findings in neonatal cases can rule out hypoxic ischemic encephalopathy, which suggests an additional screening method to look for mitochondrial disorder.

Published
2001

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