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1. Test of internal-conversion theory with a measurement in 111Cd

Author

Nica N., Hardy J.C., Iacob V.E., Werke T.A., Folden III C.M., Pineda L., and Trzhaskovskaya M.B.

Subjects
Physics, QC1-999
Abstract

We have measured the K-shell and total internal conversion coefficients for the 150.8-keV E3 transition in 111Cd: αK = 1.449(18) and αT = 2.217(26) respectively. The αK value agrees well with Dirac-Fock calculations, in which the effect of the K-shell atomic vacancy is included. It is consistent with our previous precise measurements of αK values, which cover a range of atomic numbers, and extends that range down to Z = 48. The αT measurement, however, disagrees by about two standard deviations from the calculated αT value, whether the atomic vacancy is included or not.

Published
2017
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3. Testing CVC and CKM Unitarity via superallowed nuclear beta decay

Author

Hardy J.C., Towner I.S., Park H.I., Iacob V.E., Chen L., Horvat V., Nica N., and Bencomo M.

Subjects
Physics, QC1-999
Abstract

Currently, the most restrictive test of the unitarity of the Cabibbo-Kobayashi-Maskawa (CKM) matrix is anchored by nuclear beta decay. Precise measurements of the ft-values for superallowed beta transitions between analog 0+ states are used to determine GV, the vector coupling constant; this, in turn, yields Vud, the up-down quark-mixing element of the CKM matrix. The determination of a transition’s ft-value requires the measurement of three quantities: its Q value, branching ratio and parent half-life. To achieve 0.1% precision on the final result, each of these quantities must be measured to substantially better precision, for which special techniques have had to be developed. A new survey and analysis of world data reveals that there are now fourteen such transitions with ft-values known to ∼ 0.1% precision or better, and that they span a wide range of nuclear masses, from 10C, the lightest parent, to 74Rb, the heaviest. Of particular interest is the recent completion of the first mirror pair of 0+ → 0+ transitions, 38Ca → 38mK and 38mK → 38Ar, which provides a valuable constraint on the calculated isospin-symmetry-breaking corrections needed to derive GV from the experimental data. As anticipated by the Conserved Vector Current hypothesis, CVC, all fourteen transitions yield consistent values for GV. The value of Vud derived from their average makes it by far the most precisely known element of the CKM matrix, which, when combined with the other top-row elements, Vus and Vub, leads to the most demanding test available of the unitarity of that matrix. Since CKM unitarity is a key pillar of the Electroweak Standard Model, this test is of fundamental significance.

Published
2015
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4. A novel approach to medical radioisotope production using inverse kinematics: a successful production test of the theranostic radionuclide 67Cu

Author

Souliotis, G, Rodrigues, M, Wang, K, Iacob, V, Nica, N, Roeder, B, Tabacaru, G, Yu, M, Zanotti-Fregonara, P, and Bonasera, A

Subjects
Physics - Medical Physics, Nuclear Experiment
Abstract

A novel method for the production of important medical radioisotopes has been developed. The approach is based on performing the nuclear reaction in inverse kinematics, namely sending a heavy-ion beam of appropriate energy on a light target (e.g. H, d, He) and collecting the isotope of interest. In this work, as a proof-of-concept, we studied the production of the theranostic radionuclide 67Cu (T 1/2 =62 h) via the reaction of a 70Zn beam at 15 MeV/nucleon with a hydrogen gas target. The 67Cu radionuclide, alongside other coproduced isotopes, was collected after the gas target on an Al catcher foil and their radioactivity was measured by off-line {\gamma}-ray analysis. After 36 h from the end of the irradiation, apart from the product of interest 67Cu, the main radioimpurity coming from the 70Zn+p reaction was 69mZn (T 1/2 =13.8 h) that can be reduced by further radio-cooling. Moreover, along with the radionuclide of interest produced in inverse kinematics, the production of additional radioisotopes is possible by making use of the forward-focused neutrons from the reaction and letting them interact with a secondary target. A preliminary successful test of this concept was realized in the present study. The main requirement to obtain activities appropriate for preclinical studies is the development of high-intensity heavy-ion primary beams., Comment: 8 pages, 3 figures, submitted to Applied Radiation and Isotopes

Published
2019

6. Precise measurement of $\alpha_K$ and $\alpha_T$ for the 39.8-keV $E$3 transition in $^{103}$Rh: Test of internal-conversion theory

Author

Nica, N., Hardy, J. C., Iacob, V. E., Horvat, V., Park, H. I., Werke, T. A., Glennon, K. J., Folden III, C. M., Sabla, V. I., Bryant, J. B., James, X. K., and Trzhaskovskaya, M. B.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

Neutron-activated sources of $^{103}$Ru and $^{103}$Pd both share the isomeric first-excited state in $^{103}$Rh as a daughter product. From independent measurements of both decays, we have measured the $K$-shell and total internal conversion coefficients, $\alpha_K$ and $\alpha_T$, for the 39.8-keV $E$3 transition, which de-excites that state in $^{103}$Rh, to be 141.1(23) and 1428(13), respectively. When compared with Dirac-Fock calculations, our new results disagree with the version of the theory that ignores the $K$-shell atomic vacancy, which is consistent with our conclusion drawn from a series of measurements on high multipolarity transitions in nuclei with higher $Z$. Calculations that include the atomic vacancy indicate that the transition actually has a small $M$4 component with mixing ratio $\delta$ = 0.023(5)., Comment: 12 pages, 6 figures. arXiv admin note: text overlap with arXiv:1704.03074, arXiv:1702.07668

Published
2018
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7. Precise half-life measurement of the superallowed emitter 30S

Author

Iacob, V. E., Hardy, J. C., Chen, L., Horvat, V., Bencomo, M., Nica, N., Park, H. I., Roeder, B. T., and Saastamoinen, A.

Subjects
Nuclear Experiment
Abstract

We have measured the half-life of 30S, the parent of a superallowed 0+-to-0+ beta transition, to high precision using very pure sources and a 4pi proportional gas counter to detect the decay positrons. Our result for the half-life is 1.17992(34) s. As a byproduct of this measurement, we determined the half-life of its daughter, 30P, to be 2.501(2) min., Comment: 9 pages, 7 figures

Published
2018
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8. Precise Test of Internal-Conversion Theory: alpha_K Measurements for Transitions in Nine Nuclei Spanning Z values from 45 to 78

Author

Hardy, J. C., Nica, N., Iacob, V. E., and Trzhaskovskaya, M. B.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

We have been testing the theory used to calculate internal-conversion coefficients (ICCs) by making a series of measurements of alpha_K values with precision better than +/-2%. So far we have measured E3 transitions in three nuclei, 103Rh, 111Cd and 134Cs; and M4 transitions in six nuclei, 119Sn, 125Te, 127Te, 137Ba, 193Ir and 197Pt. Together, these span a wide range of A and Z values. In all cases, the results strongly favor Dirac-Fock calculations in which the final-state electron wave function has been computed in an atomic field that includes the vacancy created by the internal-conversion process.

Published
2017

9. Precise measurement of alpha_K and alpha_T for the 109.3-keV M4 transition in 125Te: Test of internal-conversion theory

Author

Nica, N., Hardy, J. C., Iacob, V. E., Werke, T. A., Folden III, C. M., Ofodile, K., and Trzhaskovskaya, M. B.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

We have measured the K-shell and total internal conversion coefficients (ICCs), alpha_K and alpha_T, for the 109.3-keV M4 transition in 125Te to be 185.0(40) and 350.0(38), respectively. Previously this transition's ICCs were considered anomalous, with alpha values lying below calculated values. When compared with Dirac-Fock calculations, our new results show good agreement. The alpha_K result agrees well with the version of the theory that takes account of the K-shell atomic vacancy and disagrees with the one that does not. This is consistent with our conclusion drawn from a series of high multipolarity transitions., Comment: 7 pages, 3 figures. arXiv admin note: substantial text overlap with arXiv:1702.07668, arXiv:1512.06898

Published
2017
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10. Precise measurement of alpha_K for the 88.2-keV M4 transition in 127Te: Test of internal-conversion theory

Author

Nica, N., Hardy, J. C., Iacob, V. E., Park, H. I., Brandenburg, K., and Trzhaskovskaya, M. B.

Subjects
Nuclear Experiment
Abstract

We have measured the K-shell internal conversion coefficient, alpha_K, for the 88.2-keV M4 transition from the 106-day isomer to the ground state in 127Te to be 484(6). When compared with Dirac-Fock calculations of alpha_K, this result agrees well with the version of the theory that incorporates the effect of the K-shell atomic vacancy and disagrees with the one that does not. As a byproduct of this measurement, we have determined the beta branching from the isomer to be 2.14(3)%., Comment: 7 pages, three figures. arXiv admin note: text overlap with arXiv:1512.06898, arXiv:1312.3883

Published
2017

13. Precise measurement of alpha_K and alpha_T for the 150.8-keV E3 transition in 111Cd: Test of internal-conversion theory

Author

Nica, N., Hardy, J. C., Iacob, V. E., Werke, T. A., Folden III, C. M., Pineda, L., and Trzhaskovskaya, M. B.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

We have measured the K-shell and total internal conversion coefficients, alpha_K and alpha_T, for the 150.8-keV E3 transition in 111Cd to be 1.449(18) and 2.217(26) respectively. The alpha_K result agrees well with Dirac-Fock calculations in which the effect of the K-shell atomic vacancy is accounted for; it extends our precision tests of alpha_K calculations to Z = 48, the lowest Z yet measured. However, the result for alpha_T disagrees by about two standard deviations from the calculated alpha_T value, whether or not the atomic vacancy is included., Comment: 7 pages, two figures. arXiv admin note: text overlap with arXiv:1312.3883

Published
2015
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14. Precise measurement of branching ratios in the beta decay of 38Ca

Author

Park, H. I., Hardy, J. C., Iacob, V. E., Bencomo, M., Chen, L., Horvat, V., Nica, N., Roeder, B. T., McCleskey, E., Tribble, R. E., and Towner, I. S.

Subjects
Nuclear Experiment, High Energy Physics - Phenomenology, Nuclear Theory
Abstract

We present the full description of a measurement of the branching ratios for the beta-decay of 38Ca. This decay includes five allowed 0+ --> 1+ branches and a superallowed 0+ --> 0+ one. With our new result for the latter, we determine its ft value to be 3062.3(68) s, a result whose precision (0.2%) is comparable to the precision of the thirteen well known 0+ --> 0+ transitions used up till now for the determination of Vud, the up-down quark-mixing element of the CKM matrix. The 38Ca superallowed transition thus becomes the first addition to this set of transitions in nearly a decade and the first for which a precise mirror comparison is possible, thus enabling an improved test of the isospin-symmetry-breaking corrections required for the extraction of Vud., Comment: 14 pages, 8 figures

Published
2015

16. Nuclear Data Sheets for A=162.

Author

Nica, N.

Subjects
*NUCLIDES, *RARE earth metals
Abstract

The experimental results published before September 2023 from the various reaction and decay studies leading to nuclides of Z=60 to Z=76, 162Nd, 162Pm, 162Sm, 162Eu, 162Gd, 162Tb, 162Dy, 162Ho, 162Er, 162Tm, 162Yb, 162Lu, 162Hf, 162Ta, 162W, 162Re 162Os, in the A=162 mass chain have been reviewed. These data are summarized and presented, together with adopted level schemes and properties. This work is intended to supersede the previous evaluation of the A=162 nuclides by C.W.Reich (2007Re16), which was published in Nuclear Data Sheets 108, 1807 (2007). [ABSTRACT FROM AUTHOR]

Published
2024
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17. The beta decay of 38Ca: Sensitive test of isospin symmetry-breaking corrections from mirror superallowed 0+-to-0+ transitions

Author

Park, H. I., Hardy, J. C., Iacob, V. E., Bencomo, M., Chen, L., Horvat, V, Nica, N., Roeder, B. T., Simmons, E., Tribble, R. E., and Towner, I. S.

Subjects
Nuclear Experiment, High Energy Physics - Phenomenology, Nuclear Theory
Abstract

We report the first branching-ratio measurement of the superallowed 0+-to-0+ beta transition from 38Ca. The result, 0.7728(16), leads to an ft value of 3062.3(68)s with a relative precision of +/-0.2%. This makes possible a high-precision comparison of the ft values for the mirror superallowed transitions, 38Ca-to-38mK and 38mK-to-38Ar, which sensitively tests the isospin symmetry-breaking corrections required to extract Vud, the up-down quark-mixing element of the Cabibbo-Kobayashi-Maskawa (CKM) matrix, from superallowed beta decay. The result supports the corrections currently used, and points the way to even tighter constraints on CKM unitarity., Comment: 5 pages, 3 figures

Published
2014
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18. Precise measurement of alpha-K for the 65.7-keV M4 transition in 119Sn: Extended test of internal-conversion theory

Author

Nica, N., Hardy, J. C., Iacob, V. E., Bencomo, M., Horvat, V., Park, H. I., Maguire, M., Miller, S., and Trzhaskovskaya, M. B.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

We have measured the K-shell internal conversion coefficient, alpha-K, for the 65.7-keV M4 transition in 119Sn to be 1621(25). This result agrees well with Dirac-Fock calculations in which the effect of the K-shell atomic vacancy is accounted for, and disagrees with calculations in which the vacancy is ignored. This extends our precision tests of theory to Z = 50, the lowest Z yet measured., Comment: 10 pages, 7 figures

Published
2013

21. Precise Half-Life Measurement of the Superallowed Beta+ Emitter 46V

Author

Park, H. I., Hardy, J. C., Iacob, V. E., Chen, L., Goodwin, J., Nica, N., Simmons, E., Trache, L., and Tribble, R. E.

Subjects
Nuclear Experiment
Abstract

The half-life of 46V has been measured to be 422.66(6) ms, which is a factor of two more precise than the best previous measurement. Our result is also consistent with the previous measurements, with no repeat of the disagreement recently encountered with Q_{EC} values measured for the same transition. The Ft value for the 46V superallowed transition, incorporating all world data, is determined to be 3074.1(26) s, a result consistent with the average Ft value of 3072.08(79) s established from the 13 best-known superallowed transitions., Comment: 6 pages, 6 figures

Published
2011
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22. The beta Decay of 32Cl: Precision gamma-Ray Spectroscopy and a Measurement of Isospin-Symmetry Breaking

Author

Melconian, D., Triambak, S., Bordeanu, C., García, A., Hardy, J. C., Iacob, V. E., Nica, N., Park, H. I., Tabacaru, G., Trache, L., Towner, I. S., Tribble, R. E., and Zhai, Y.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

Background: Models to calculate small isospin-symmetry-breaking effects in superallowed Fermi decays have been placed under scrutiny in recent years. A stringent test of these models is to measure transitions for which the correction is predicted to be large. The decay of 32Cl decay provides such a test case. Purpose: To improve the gamma yields following the beta decay of 32Cl and to determine the ft values of the the beta branches, particularly the one to the isobaric-analogue state in 32S. Method: Reaction-produced and recoil-spectrometer-separated 32Cl is collected in tape and transported to a counting location where beta-gamma coincidences are measured with a precisely-calibrated HPGe detector. Results: The precision on the gamma yields for most of the known beta branches has been improved by about an order of magnitude, and many new transitions have been observed. We have determined 32Cl-decay transition strengths extending up to E_x~11 MeV. The ft value for the decay to the isobaric-analogue state in 32S has been measured. A comparison to a shell-model calculation shows good agreement. CONCLUSIONS: We have experimentally determined the isospin-symmetry-breaking correction to the superallowed transition of this decay to be (\delta_C-\delta_NS)_exp=5.4(9)%, significantly larger than for any other known superallowed Fermi transition. This correction agrees with a shell-model calculation, which yields \delta_C-\delta_NS=4.8(5)%. Our results also provide a way to improve the measured ft values for the beta decay of 32Ar.

Published
2011
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23. Experimental Validation of the Largest Calculated Isospin-Symmetry-Breaking Effect in a Superallowed Fermi Decay

Author

Melconian, D., Triambak, S., Bordeanu, C., García, A., Hardy, J. C., Iacob, V. E., Nica, N., Park, H. I., Tabacaru, G., Trache, L., Towner, I. S., Tribble, R. E., and Zhai, Y.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

A precision measurement of the gamma yields following the beta decay of 32Cl has determined its isobaric analogue branch to be (22.47^{+0.21}_{-0.19})%. Since it is an almost pure Fermi decay, we can also determine the amount of isospin-symmetry breaking in this superallowed transition. We find a very large value, delta_C=5.3(9)%, in agreement with a shell-model calculation. This result sets a benchmark for isospin-symmetry-breaking calculations and lends support for similarly-calculated, yet smaller, corrections that are currently applied to 0+ -> 0+ transitions for tests of the Standard Model.

Published
2011
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24. Measurement of the half-life of 198Au in a non-metal: High-precision measurement shows no host-material dependence

Author

Goodwin, J. R., Nica, N., Iacob, V. E., Dibidad, A., and Hardy, J. C.

Subjects
Nuclear Experiment
Abstract

We have measured the half-life of the beta decay of 198Au to be 2.6948(9) d, with the nuclide sited in an insulating environment. Comparing this result with the half-life we measured previously with a metallic environment, we find the half-lives in both environments to be the same within 0.04%, thus contradicting a prediction that screening from a "plasma" of quasi-free electrons in a metal increases the half-life by as much as 7%.

Published
2010
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25. Precise Half-Life Measurement of the Superallowed Beta+ Emitter 26Si

Author

Iacob, V. E., Hardy, J. C., Banu, A., Chen, L., Golovko, V. V., Goodwin, J., Horvat, V., Nica, N., Park, H. I., Trache, L., and Tribble, R. E.

Subjects
Nuclear Experiment
Abstract

We have measured the half-life of the superallowed 0+ -to- 0+ beta+ emitter 26Si to be 2245.3(7) ms. We used pure sources of 26Si and employed a high-efficiency gas counter, which was sensitive to positrons from both this nuclide and its daughter 26mAl. The data were analyzed as a linked parent-daughter decay. To contribute meaningfully to any test of the unitarity of the Cabibbo-Kobayashi-Maskawa (CKM) matrix, the ft value of a superallowed transition must be determined to a precision of 0.1% or better. With a precision of 0.03% the present result is more than sufficient to be compatable with that requirement. Only the branching ratio now remains to be measured precisely before a +/-0.1% ft value can be obtained for the superallowed transition from 26Si.

Published
2010
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27. Precise Half-Life Measurement of the Superallowed beta emitter 10C

Author

Iacob, V. E., Hardy, J. C., Golovko, V., Goodwin, J., Nica, N., Park, H. I., Trache, L., and Tribble, R. E.

Subjects
Nuclear Experiment
Abstract

The half-life of 10C has been measured to be 19.310(4)s, a result with 0.02% precision, which is a factor of three improvement over the best previous result. Since 10C is the lightest superallowed 0+ --> 0+ beta emitter, its ft value has the greatest weight in setting an upper limit on the possible presence of scalar currents., Comment: 4 pages, 3 figures

Published
2007
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28. Branching ratios for the beta decay of 21Na

Author

Iacob, V. E., Hardy, J. C., Gagliardi, C. A., Goodwin, J., Nica, N., Park, H. I., Tabacaru, G., Trache, L., Tribble, R., Zhai, Y., and Towner, I. S.

Subjects
Nuclear Experiment, High Energy Physics - Phenomenology, Nuclear Theory
Abstract

We have measured the beta-decay branching ratio for the transition from 21Na to the first excited state of 21Ne. A recently published test of the standard model, which was based on a measurement of the beta-nu correlation in the decay of 21Na, depended on this branching ratio. However, until now only relatively imprecise (and, in some cases, contradictory) values existed for it. Our new result, 4.74(4)%, reduces but does not remove the reported discrepancy with the standard model., Comment: Revtex4, 2 figs

Published
2006
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35. Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice:: GLORIA-AF Registry

Author

Lip G. Y. H., Kotalczyk A., Teutsch C., Diener H. -C., Dubner S. J., Halperin J. L., Ma C. -S., Rothman K. J., Marler S., Gurusamy V. K., Huisman M. V., Abban D. W., Aziz E., Kalan M. B., Abdul N., Backes L. M., Bradman D., Abud A. M., Badings E., Brautigam D., Adams F., Bagni E., Breton N., Addala S., Baker S. H., Brouwers P. J. A. M., Adragao P., Bala R., Browne K., Ageno W., Baldi A., Cortada J. B., Aggarwal R., Bando S., Bruni A., Agosti S., Banerjee S., Brunschwig C., Agostoni P., Bank A., Buathier H., Aguilar F., Esquivias G. B., Buhl A., Linares J. A., Barr C., Bullinga J., Aguinaga L., Bartlett M., Cabrera J. W., Ahmed J., Basic Kes V., Caccavo A., Aiello A., Baula G., Cai S., Ainsworth P., Behrens S., Caine S., Aiub J. R., Bell A., Calo L., Al-Dallow R., Benedetti R., Calvi V., Alderson L., Mazuecos J. B., Sanchez M. C., Velasco J. A. A., Benhalima B., Candeias R., Alexopoulos D., Bergler-Klein J., Capuano V., Manterola F. A., Berneau J. -B., Capucci A., Aliyar P., Bernstein R. A., Caputo R., Alonso D., Berrospi P., Rizo T. C., da Costa F. A. A., Berti S., Cardona F., Amado J., Berz A., da Costa Darrieux F. C., Amara W., Best E., Vera Y. C. D., Amelot M., Bettencourt P., Carolei A., Amjadi N., Betzu R., Carreno S., Ammirati F., Bhagwat R., Carvalho P., Andrade M., Bhatta L., Cary S., Andrawis N., Biscione F., Casu G., Annoni G., Bisignani G., Cavallini C., Ansalone G., Black T., Cayla G., Ariani M. K., Bloch M. J., Celentano A., Arias J. C., Bloom S., Cha T. -J., Armero S., Blumberg E., Cha K. S., Arora C., Bo M., Chae J. K., Aslam M. S., Bohmer E., Chalamidas K., Asselman M., Bollmann A., Challappa K., Audouin P., Bongiorni M. G., Chand S. P., Augenbraun C., Boriani G., Chandrashekar H., Aydin S., Boswijk D. J., Chartier L., Bott J., Chatterjee K., Ayryanova I., Bottacchi E., Ayala C. A. C., Cheema A., Davis G., Evonich R., Davy J. -M., Evseeva O., Chen L., Dayer M., Ezhov A., Chen S. -A., De Biasio M., Fahmy R., Chen J. H., De Bonis S., Fang Q., Chiang F. -T., De Caterina R., Farsad R., Chiarella F., De Franceschi T., Fauchier L., Chih-Chan L., de Groot J. R., Favale S., Cho Y. K., De Horta J., Fayard M., Choi J. -I., De La Briolle A., Fedele J. L., Choi D. J., de la Pena Topete G., Fedele F., Chouinard G., de Paola A. A. V., Fedorishina O., Chow D. H. -F., de Souza W., Fera S. R., Chrysos D., de Veer A., Ferreira L. G. G., Chumakova G., De Wolf L., Ferreira J., Valenzuela E. J. J. R. C., Decoulx E., Ferri C., Nica N. C., Deepak S., Ferrier A., Cislowski D. J., Defaye P., Ferro H., Clay A., Munoz F. D. -C., Finsen A., Clifford P., Brkljacic D. D., First B., Cohen A., Deumite N. J., Fischer S., Cohen M., Di Legge S., Fonseca C., Cohen S., Diemberger I., Almeida L. F., Colivicchi F., Dietz D., Forman S., Collins R., Dionisio P., Frandsen B., Colonna P., Dong Q., French W., Compton S., dos Santos F. R., Friedman K., Connolly D., Dotcheva E., Friese A., Conti A., Doukky R., Fruntelata A. G., Buenostro G. C., D'Souza A., Fujii S., Coodley G., Dubrey S., Fumagalli S., Cooper M., Ducrocq X., Fundamenski M., Coronel J., Dupljakov D., Furukawa Y., Corso G., Duque M., Gabelmann M., Sales J. C., Dutta D., Gabra N., Cottin Y., Duvilla N., Gadsboll N., Covalesky J., Duygun A., Galinier M., Cracan A., Dziewas R., Gammelgaard A., Crea F., Eaton C. B., Ganeshkumar P., Crean P., Eaves W., Gans C., Crenshaw J., Ebels-Tuinbeek L. A., Quintana A. G., Cullen T., Ehrlich C., Gartenlaub O., Darius H., Eichinger-Hasenauer S., Gaspardone A., Dary P., Eisenberg S. J., Genz C., Dascotte O., Jabali A. E., Georger F., Dauber I., Shahawy M. E., Georges J. -L., Davalos V., Hernandes M. E., Georgeson S., Davies R., Izal A. E., Giedrimas E., Gierba M., Haruna T., Jarmukli N., Ortega I. G., Hayek E., Jeanfreau R. J., Gillespie E., Healey J., Jenkins R. D., Giniger A., Hearne S., Sanchez C. J., Giudici M. C., Heffernan M., Jimenez J., Gkotsis A., Heggelund G., Jobe R., Glotzer T. V., Heijmeriks J. A., Joen-Jakobsen T., Gmehling J., Hemels M., Jones N., Gniot J., Hendriks I., Jorge J. C. M., Goethals P., Henein S., Jouve B., Goldbarg S., Her S. -H., Jung B. C., Goldberg R., Hermany P., Jung K. T., Goldmann B., Del Rio J. E. H., Jung W., Golitsyn S., Higashino Y., Kachkovskiy M., Gomez S., Hill M., Kafkala K., Mesa J. G., Hisadome T., Kalinina L., Gonzalez V. B., Hishida E., Kallmunzer B., Hermosillo J. A. G., Hoffer E., Kamali F., Lopez V. M. G., Hoghton M., Kamo T., Gorka H., Hong K., Kampus P., Gornick C., Hong S., Kashou H., Gorog D., Horbach S., Kastrup A., Gottipaty V., Horiuchi M., Katsivas A., Goube P., Hou Y., Kaufman E., Goudevenos I., Hsing J., Kawai K., Graham B., Huang C. -H., Kawajiri K., Greer G. S., Huckins D., Kazmierski J. F., Gremmler U., Hughes K., Keeling P., Grena P. G., Huizinga A., Saraiva J. F. K., Grond M., Hulsman E. L., Ketova G., Gronda E., Hung K. -C., Khaira A. S., Gronefeld G., Hwang G. -S., Khripun A., Gu X., Ikpoh M., Kim D. -I., Torres I. G. T., Imberti D., Kim Y. H., Guardigli G., Ince H., Kim N. H., Guevara C., Indolfi C., Kim D. K., Guignier A., Inoue S., Kim J. S., Gulizia M., Irles D., Gumbley M., Iseki H., Kim K. S., Gunther A., Israel C. N., Kim J., Ha A., Iteld B., Kinova E., Hahalis G., Iyer V., Klein A., Hakas J., Jackson-Voyzey E., Kmetzo J. J., Hall C., Jaffrani N., Kneller G. L., Han B., Jager F., Knezevic A., Han S., James M., Koh S. M. A., Hargrove J., Jang S. -W., Koide S., Hargroves D., Jaramillo N., Kollias A., Kooistra J. A., Li W., McClure J., Koons J., Li X., McCormack T., Koschutnik M., Lichy C., McGarity W., Kostis W. J., Lieber I., McIntyre H., Kovacic D., Rodriguez R. H. L., McLaurin B., Kowalczyk J., Lin H., Alvaro F., Palomino M., Koziolova N., Melandri F., Kraft P., Liu F., Meno H., Kragten J. A., Liu H., Menzies D., Krantz M., Esperon G. L., Mercader M., Krause L., Navarro N. L., Meyer C., Krenning B. J., Lo E., Meyer B. J., Krikke F., Lokshyn S., Miarka J., Kromhout Z., Lopez A., Mibach F., Krysiak W., Lopez-Sendon J. L., Michalski D., Kumar P., Filho A. M. L., Michel P., Kumler T., Lorraine R. S., Chreih R. M., Kuniss M., Luengas C. A., Luengas A., Mikdadi G., Kuo J. -Y., Luke R., Mikus M., Kuppers A., Luo M., Milicic D., Kurrelmeyer K., Lupovitch S., Militaru C., Kwak C. H., Lyrer P., Minaie S., Laboulle B., Ma C., Minescu B., Labovitz A., Ma G., Mintale I., Ter Lai W., Madariaga I., Mirault T., Lam A., Maeno K., Mirro M. J., Lam Y. Y., Magnin D., Mistry D., Lanas Zanetti F., Maid G., Miu N. V., Landau C., Mainigi S. K., Miyamoto N., Landini G., Makaritsis K., Moccetti T., Lanna Figueiredo E., Malhotra R., Mohammed A., Larsen T., Manning R., Nor A. M., Lavandier K., Manolis A., Mollerus M., LeBlanc J., Hurtado H. A. M., Molon G., Lee M. H., Mantas I., Mondillo S., Lee C. -H., Jattin F. M., Moniz P., Lehman J., Maqueda V., Mont L., Leitao A., Marchionni N., Montagud V., Lellouche N., Ortuno F. M., Montana O., Lelonek M., Santana A. M., Monti C., Lenarczyk R., Martinez J., Moretti L., Lenderink T., Maskova P., Mori K., Gonzalez S. L., Hernandez N. M., Moriarty A., Leong-Sit P., Matsuda K., Morka J., Leschke M., Maurer T., Moschini L., Ley N., Mauro C., Moschos N., Li Z., May E., Mugge A., Mayer N., Mulhearn T. J., Muresan C., Jose E. P., Precoma D. 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R., Nowalany-Kozielska E., Pflucke C., Escudero A. E. R., Nsah E., Pham D. N., Pascual C. R., Fragoso J. C. N., Phillips R. T., Roman M., Nurgalieva S., Phlaum S., Romeo F., Nuyens D., Pieters D., Ronner E., Nyvad O., Pineau J., Roux J. -F., de Los Rios Ibarra M. O., Pinter A., Rozkova N., O'Donnell P., Pinto F., Rubacek M., O'Donnell M., Pisters R., Rubalcava F., Oh S., Pivac N., Russo A. M., Oh Y. S., Pocanic D., Rutgers M. P., Oh D., Podoleanu C., Rybak K., O'Hara G., Politano A., Said S., Oikonomou K., Poljakovic Z., Sakamoto T., Olivares C., Pollock S., Salacata A., Oliver R., Garcea J. P., Salem A., Ruiz R. O., Poppert H., Bodes R. S., Olympios C., Porcu M., Saltzman M. A., Omaszuk-Kazberuk A., Reino A. P., Salvioni A., Asensi J. O., Prasad N., Vallejo G. S., Fernandez M. S., Sokal A., Tu T. M., Saporito W. F., Yan Y. S. O., Tuininga Y., Sarikonda K., Sotolongo R., Turakhia M., Sasaoka T., de Souza O. F., Turk S., Sati H., Sparby J. A., Turner W., Savelieva I., Spinar J., Tveit A., Scala P. -J., Sprigings D., Tytus R., Schellinger P., Spyropoulos A. C., Valadao C., Scherr C., Stakos D., van Bergen P. F. M. M., Schmitz L., Steinwender C., van de Borne P., Schmitz K. -H., Stergiou G., van den Berg B. J., Schmitz B., Stiell I., van der Zwaan C., Schnabel T., Stoddard M., Van Eck M., Schnupp S., Stoikov A., Vanacker P., Schoeniger P., Streb W., Vasilev D., Schon N., Styliadis I., Vasilikos V., Schwimmbeck P., Su G., Vasilyev M., Seamark C., Su X., Veerareddy S., Searles G., Sudnik W., Mino M. V., Seidl K. -H., Sukles K., Venkataraman A., Seidman B., Sun X., Verdecchia P., Sek J., Swart H., Versaci F., Sekaran L., Szavits-Nossan J., Vester E. G., Serrati C., Taggeselle J., Vial H., Shah N., Takagi Y., Victory J., Shah V., Takhar A. P. S., Villamil A., Shah A., Tamm A., Vincent M., Shah S., Tanaka K., Vlastaris A., Sharma V. K., Tanawuttiwat T., Dahl J., Shaw L., Tang S., Vora K., Sheikh K. H., Tang A., Vranian R. B., Shimizu N., Tarsi G., Wakefield P., Shimomura H., Tassinari T., Wang N., Shin D. -G., Tayal A., Wang M., Shin E. -S., Tayebjee M., Wang X., Shite J., Berg J. M., Wang F., Sibilio G., Tesloianu D., Wang T., Silver F., The S. H. K., Warner A. L., Sime I., Thomas D., Watanabe K., Simmers T. A., Timsit S., Wei J., Singh N., Tobaru T., Weimar C., Siostrzonek P., Tomasik A. R., Weiner S., Smadja D., Torosoff M., Weinrich R., Smith D. W., Touze E., Wen M. -S., Snitman M., Trendafilova E., Wiemer M., Filho D. S., Tsai W. K., Wiggers P., Soda H., Tse H. F., Wilke A., Sofley C., Tsutsui H., Williams D., Williams M. L., Yan P. Y. B., Zhang P., Witzenbichler B., Yang T., Zhang J., Wong B., Yao J., Zhao S. P., Wong K. S. L., Yeh K. -H., Zhao Y., Wozakowska-Kaplon B., Yin W. H., Zhao Z., Wu S., Yotov Y., Zheng Y., Wu R. C., Zahn R., Zhou J., Wunderlich S., Zarich S., Zimmermann S., Wyatt N., Zenin S., Zini A., Wylie J., Zeuthen E. L., Zizzo S., Xu Y., Zhang H., Zong W., Xu X., Zhang D., Zukerman L. S., Yamanoue H., Zhang X., Yamashita T., Cardiology, ACS - Heart failure & arrhythmias, Lip G.Y.H., Kotalczyk A., Teutsch C., Diener H.-C., Dubner S.J., Halperin J.L., Ma C.-S., Rothman K.J., Marler S., Gurusamy V.K., Huisman M.V., Abban D.W., Aziz E., Kalan M.B., Abdul N., Backes L.M., Bradman D., Abud A.M., Badings E., Brautigam D., Adams F., Bagni E., Breton N., Addala S., Baker S.H., Brouwers P.J.A.M., Adragao P., Bala R., Browne K., Ageno W., Baldi A., Cortada J.B., Aggarwal R., Bando S., Bruni A., Agosti S., Banerjee S., Brunschwig C., Agostoni P., Bank A., Buathier H., Aguilar F., Esquivias G.B., Buhl A., Linares J.A., Barr C., Bullinga J., Aguinaga L., Bartlett M., Cabrera J.W., Ahmed J., Basic Kes V., Caccavo A., Aiello A., Baula G., Cai S., Ainsworth P., Behrens S., Caine S., Aiub J.R., Bell A., Calo L., Al-Dallow R., Benedetti R., Calvi V., Alderson L., Mazuecos J.B., Sanchez M.C., Velasco J.A.A., Benhalima B., Candeias R., Alexopoulos D., Bergler-Klein J., Capuano V., Manterola F.A., Berneau J.-B., Capucci A., Aliyar P., Bernstein R.A., Caputo R., Alonso D., Berrospi P., Rizo T.C., da Costa F.A.A., Berti S., Cardona F., Amado J., Berz A., da Costa Darrieux F.C., Amara W., Best E., Vera Y.C.D., Amelot M., Bettencourt P., Carolei A., Amjadi N., Betzu R., Carreno S., Ammirati F., Bhagwat R., Carvalho P., Andrade M., Bhatta L., Cary S., Andrawis N., Biscione F., Casu G., Annoni G., Bisignani G., Cavallini C., Ansalone G., Black T., Cayla G., Ariani M.K., Bloch M.J., Celentano A., Arias J.C., Bloom S., Cha T.-J., Armero S., Blumberg E., Cha K.S., Arora C., Bo M., Chae J.K., Aslam M.S., Bohmer E., Chalamidas K., Asselman M., Bollmann A., Challappa K., Audouin P., Bongiorni M.G., Chand S.P., Augenbraun C., Boriani G., Chandrashekar H., Aydin S., Boswijk D.J., Chartier L., Bott J., Chatterjee K., Ayryanova I., Bottacchi E., Ayala C.A.C., Cheema A., Davis G., Evonich R., Davy J.-M., Evseeva O., Chen L., Dayer M., Ezhov A., Chen S.-A., De Biasio M., Fahmy R., Chen J.H., De Bonis S., Fang Q., Chiang F.-T., De Caterina R., Farsad R., Chiarella F., De Franceschi T., Fauchier L., Chih-Chan L., de Groot J.R., Favale S., Cho Y.K., De Horta J., Fayard M., Choi J.-I., De La Briolle A., Fedele J.L., Choi D.J., de la Pena Topete G., Fedele F., Chouinard G., de Paola A.A.V., Fedorishina O., Chow D.H.-F., de Souza W., Fera S.R., Chrysos D., de Veer A., Ferreira L.G.G., Chumakova G., De Wolf L., Ferreira J., Valenzuela E.J.J.R.C., Decoulx E., Ferri C., Nica N.C., Deepak S., Ferrier A., Cislowski D.J., Defaye P., Ferro H., Clay A., Munoz F.D.-C., Finsen A., Clifford P., Brkljacic D.D., First B., Cohen A., Deumite N.J., Fischer S., Cohen M., Di Legge S., Fonseca C., Cohen S., Diemberger I., Almeida L.F., Colivicchi F., Dietz D., Forman S., Collins R., Dionisio P., Frandsen B., Colonna P., Dong Q., French W., Compton S., dos Santos F.R., Friedman K., Connolly D., Dotcheva E., Friese A., Conti A., Doukky R., Fruntelata A.G., Buenostro G.C., D'Souza A., Fujii S., Coodley G., Dubrey S., Fumagalli S., Cooper M., Ducrocq X., Fundamenski M., Coronel J., Dupljakov D., Furukawa Y., Corso G., Duque M., Gabelmann M., Sales J.C., Dutta D., Gabra N., Cottin Y., Duvilla N., Gadsboll N., Covalesky J., Duygun A., Galinier M., Cracan A., Dziewas R., Gammelgaard A., Crea F., Eaton C.B., Ganeshkumar P., Crean P., Eaves W., Gans C., Crenshaw J., Ebels-Tuinbeek L.A., Quintana A.G., Cullen T., Ehrlich C., Gartenlaub O., Darius H., Eichinger-Hasenauer S., Gaspardone A., Dary P., Eisenberg S.J., Genz C., Dascotte O., Jabali A.E., Georger F., Dauber I., Shahawy M.E., Georges J.-L., Davalos V., Hernandes M.E., Georgeson S., Davies R., Izal A.E., Giedrimas E., Gierba M., Haruna T., Jarmukli N., Ortega I.G., Hayek E., Jeanfreau R.J., Gillespie E., Healey J., Jenkins R.D., Giniger A., Hearne S., Sanchez C.J., Giudici M.C., Heffernan M., Jimenez J., Gkotsis A., Heggelund G., Jobe R., Glotzer T.V., Heijmeriks J.A., Joen-Jakobsen T., Gmehling J., Hemels M., Jones N., Gniot J., Hendriks I., Jorge J.C.M., Goethals P., Henein S., Jouve B., Goldbarg S., Her S.-H., Jung B.C., Goldberg R., Hermany P., Jung K.T., Goldmann B., Del Rio J.E.H., Jung W., Golitsyn S., Higashino Y., Kachkovskiy M., Gomez S., Hill M., Kafkala K., Mesa J.G., Hisadome T., Kalinina L., Gonzalez V.B., Hishida E., Kallmunzer B., Hermosillo J.A.G., Hoffer E., Kamali F., Lopez V.M.G., Hoghton M., Kamo T., Gorka H., Hong K., Kampus P., Gornick C., Hong S., Kashou H., Gorog D., Horbach S., Kastrup A., Gottipaty V., Horiuchi M., Katsivas A., Goube P., Hou Y., Kaufman E., Goudevenos I., Hsing J., Kawai K., Graham B., Huang C.-H., Kawajiri K., Greer G.S., Huckins D., Kazmierski J.F., Gremmler U., Hughes K., Keeling P., Grena P.G., Huizinga A., Saraiva J.F.K., Grond M., Hulsman E.L., Ketova G., Gronda E., Hung K.-C., Khaira A.S., Gronefeld G., Hwang G.-S., Khripun A., Gu X., Ikpoh M., Kim D.-I., Torres I.G.T., Imberti D., Kim Y.H., Guardigli G., Ince H., Kim N.H., Guevara C., Indolfi C., Kim D.K., Guignier A., Inoue S., Kim J.S., Gulizia M., Irles D., Gumbley M., Iseki H., Kim K.S., Gunther A., Israel C.N., Kim J., Ha A., Iteld B., Kinova E., Hahalis G., Iyer V., Klein A., Hakas J., Jackson-Voyzey E., Kmetzo J.J., Hall C., Jaffrani N., Kneller G.L., Han B., Jager F., Knezevic A., Han S., James M., Koh S.M.A., Hargrove J., Jang S.-W., Koide S., Hargroves D., Jaramillo N., Kollias A., Kooistra J.A., Li W., McClure J., Koons J., Li X., McCormack T., Koschutnik M., Lichy C., McGarity W., Kostis W.J., Lieber I., McIntyre H., Kovacic D., Rodriguez R.H.L., McLaurin B., Kowalczyk J., Lin H., Alvaro F., Palomino M., Koziolova N., Melandri F., Kraft P., Liu F., Meno H., Kragten J.A., Liu H., Menzies D., Krantz M., Esperon G.L., Mercader M., Krause L., Navarro N.L., Meyer C., Krenning B.J., Lo E., Meyer B.J., Krikke F., Lokshyn S., Miarka J., Kromhout Z., Lopez A., Mibach F., Krysiak W., Lopez-Sendon J.L., Michalski D., Kumar P., Filho A.M.L., Michel P., Kumler T., Lorraine R.S., Chreih R.M., Kuniss M., Luengas C.A., Luengas A., Mikdadi G., Kuo J.-Y., Luke R., Mikus M., Kuppers A., Luo M., Milicic D., Kurrelmeyer K., Lupovitch S., Militaru C., Kwak C.H., Lyrer P., Minaie S., Laboulle B., Ma C., Minescu B., Labovitz A., Ma G., Mintale I., Ter Lai W., Madariaga I., Mirault T., Lam A., Maeno K., Mirro M.J., Lam Y.Y., Magnin D., Mistry D., Lanas Zanetti F., Maid G., Miu N.V., Landau C., Mainigi S.K., Miyamoto N., Landini G., Makaritsis K., Moccetti T., Lanna Figueiredo E., Malhotra R., Mohammed A., Larsen T., Manning R., Nor A.M., Lavandier K., Manolis A., Mollerus M., LeBlanc J., Hurtado H.A.M., Molon G., Lee M.H., Mantas I., Mondillo S., Lee C.-H., Jattin F.M., Moniz P., Lehman J., Maqueda V., Mont L., Leitao A., Marchionni N., Montagud V., Lellouche N., Ortuno F.M., Montana O., Lelonek M., Santana A.M., Monti C., Lenarczyk R., Martinez J., Moretti L., Lenderink T., Maskova P., Mori K., Gonzalez S.L., Hernandez N.M., Moriarty A., Leong-Sit P., Matsuda K., Morka J., Leschke M., Maurer T., Moschini L., Ley N., Mauro C., Moschos N., Li Z., May E., Mugge A., Mayer N., Mulhearn T.J., Muresan C., Jose E.P., Precoma D.B., Muriago M., Padilla F.G.P., Prelle A., Musial W., Rios V.P., Prodafikas J., Musser C.W., Pajes G., Protasov K., Musumeci F., Pandey A.S., Pye M., Nageh T., Paparella G., Qiu Z., Nakagawa H., Paris F., Quedillac J.-M., Nakamura Y., Park H.W., Raev D., Nakayama T., Park J.S., Grado C.A.R., Nam G.-B., Parthenakis F., Rahimi S., Nanna M., Passamonti E., Raisaro A., Natarajan I., Patel R.J., Rama B., Nayak H.M., Patel J., Ramos R., Naydenov S., Patel M., Ranieri M., Nazlic J., Patrick J., Raposo N., Nechita A.C., Jimenez R.P., Rashba E., Nechvatal L., Paz A., Rauch-Kroehnert U., Negron S.A., Pengo V., Reddy R., Neiman J., Pentz W., Renda G., Neuenschwander F.C., Perez B., Reza S., Neves D., Rios A.M.P., Ria L., Neykova A., Perez-Cabezas A., Richter D., Miguel R.N., Perlman R., Rickli H., Nijmeh G., Persic V., Rieker W., Nizov A., Perticone F., Vera T.R., Campos R.N., Peters T.K., Ritt L.E., Nossan J., Petkar S., Roberts D., Novikova T., Pezo L.F., Briones I.R., Nowalany-Kozielska E., Pflucke C., Escudero A.E.R., Nsah E., Pham D.N., Pascual C.R., Fragoso J.C.N., Phillips R.T., Roman M., Nurgalieva S., Phlaum S., Romeo F., Nuyens D., Pieters D., Ronner E., Nyvad O., Pineau J., Roux J.-F., de Los Rios Ibarra M.O., Pinter A., Rozkova N., O'Donnell P., Pinto F., Rubacek M., O'Donnell M., Pisters R., Rubalcava F., Oh S., Pivac N., Russo A.M., Oh Y.S., Pocanic D., Rutgers M.P., Oh D., Podoleanu C., Rybak K., O'Hara G., Politano A., Said S., Oikonomou K., Poljakovic Z., Sakamoto T., Olivares C., Pollock S., Salacata A., Oliver R., Garcea J.P., Salem A., Ruiz R.O., Poppert H., Bodes R.S., Olympios C., Porcu M., Saltzman M.A., Omaszuk-Kazberuk A., Reino A.P., Salvioni A., Asensi J.O., Prasad N., Vallejo G.S., Fernandez M.S., Sokal A., Tu T.M., Saporito W.F., Yan Y.S.O., Tuininga Y., Sarikonda K., Sotolongo R., Turakhia M., Sasaoka T., de Souza O.F., Turk S., Sati H., Sparby J.A., Turner W., Savelieva I., Spinar J., Tveit A., Scala P.-J., Sprigings D., Tytus R., Schellinger P., Spyropoulos A.C., Valadao C., Scherr C., Stakos D., van Bergen P.F.M.M., Schmitz L., Steinwender C., van de Borne P., Schmitz K.-H., Stergiou G., van den Berg B.J., Schmitz B., Stiell I., van der Zwaan C., Schnabel T., Stoddard M., Van Eck M., Schnupp S., Stoikov A., Vanacker P., Schoeniger P., Streb W., Vasilev D., Schon N., Styliadis I., Vasilikos V., Schwimmbeck P., Su G., Vasilyev M., Seamark C., Su X., Veerareddy S., Searles G., Sudnik W., Mino M.V., Seidl K.-H., Sukles K., Venkataraman A., Seidman B., Sun X., Verdecchia P., Sek J., Swart H., Versaci F., Sekaran L., Szavits-Nossan J., Vester E.G., Serrati C., Taggeselle J., Vial H., Shah N., Takagi Y., Victory J., Shah V., Takhar A.P.S., Villamil A., Shah A., Tamm A., Vincent M., Shah S., Tanaka K., Vlastaris A., Sharma V.K., Tanawuttiwat T., Dahl J., Shaw L., Tang S., Vora K., Sheikh K.H., Tang A., Vranian R.B., Shimizu N., Tarsi G., Wakefield P., Shimomura H., Tassinari T., Wang N., Shin D.-G., Tayal A., Wang M., Shin E.-S., Tayebjee M., Wang X., Shite J., Berg J.M., Wang F., Sibilio G., Tesloianu D., Wang T., Silver F., The S.H.K., Warner A.L., Sime I., Thomas D., Watanabe K., Simmers T.A., Timsit S., Wei J., Singh N., Tobaru T., Weimar C., Siostrzonek P., Tomasik A.R., Weiner S., Smadja D., Torosoff M., Weinrich R., Smith D.W., Touze E., Wen M.-S., Snitman M., Trendafilova E., Wiemer M., Filho D.S., Tsai W.K., Wiggers P., Soda H., Tse H.F., Wilke A., Sofley C., Tsutsui H., Williams D., Williams M.L., Yan P.Y.B., Zhang P., Witzenbichler B., Yang T., Zhang J., Wong B., Yao J., Zhao S.P., Wong K.S.L., Yeh K.-H., Zhao Y., Wozakowska-Kaplon B., Yin W.H., Zhao Z., Wu S., Yotov Y., Zheng Y., Wu R.C., Zahn R., Zhou J., Wunderlich S., Zarich S., Zimmermann S., Wyatt N., Zenin S., Zini A., Wylie J., Zeuthen E.L., Zizzo S., Xu Y., Zhang H., Zong W., Xu X., Zhang D., Zukerman L.S., Yamanoue H., Zhang X., and Yamashita T.

Subjects
Apixaban, Atrial fibrillation, Dabigatran, Non-vitamin K antagonists, Rivaroxaban, Pyridones, Medizin, Myocardial Infarction, Administration, Oral, Anticoagulants, Hemorrhage, General Medicine, Non-vitamin K antagonist, Stroke, Clinical Trials, Phase III as Topic, Humans, Prospective Studies, Registries, Cardiology and Cardiovascular Medicine
Abstract

Background and purpose Prospectively collected data comparing the safety and effectiveness of individual non-vitamin K antagonists (NOACs) are lacking. Our objective was to directly compare the effectiveness and safety of NOACs in patients with newly diagnosed atrial fibrillation (AF). Methods In GLORIA-AF, a large, prospective, global registry program, consecutive patients with newly diagnosed AF were followed for 3 years. The comparative analyses for (1) dabigatran vs rivaroxaban or apixaban and (2) rivaroxaban vs apixaban were performed on propensity score (PS)-matched patient sets. Proportional hazards regression was used to estimate hazard ratios (HRs) for outcomes of interest. Results The GLORIA-AF Phase III registry enrolled 21,300 patients between January 2014 and December 2016. Of these, 3839 were prescribed dabigatran, 4015 rivaroxaban and 4505 apixaban, with median ages of 71.0, 71.0, and 73.0 years, respectively. In the PS-matched set, the adjusted HRs and 95% confidence intervals (CIs) for dabigatran vs rivaroxaban were, for stroke: 1.27 (0.79–2.03), major bleeding 0.59 (0.40–0.88), myocardial infarction 0.68 (0.40–1.16), and all-cause death 0.86 (0.67–1.10). For the comparison of dabigatran vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 1.16 (0.76–1.78), myocardial infarction 0.84 (0.48–1.46), major bleeding 0.98 (0.63–1.52) and all-cause death 1.01 (0.79–1.29). For the comparison of rivaroxaban vs apixaban, in the PS-matched set, the adjusted HRs were, for stroke 0.78 (0.52–1.19), myocardial infarction 0.96 (0.63–1.45), major bleeding 1.54 (1.14–2.08), and all-cause death 0.97 (0.80–1.19). Conclusions Patients treated with dabigatran had a 41% lower risk of major bleeding compared with rivaroxaban, but similar risks of stroke, MI, and death. Relative to apixaban, patients treated with dabigatran had similar risks of stroke, major bleeding, MI, and death. Rivaroxaban relative to apixaban had increased risk for major bleeding, but similar risks for stroke, MI, and death. Registration URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01468701, NCT01671007. Date of registration: September 2013. Graphical abstract

Published
2022

36. Echinoderes goku Rucci & Neuhaus & Bulnes 2022, sp. nov

Author

Rucci, Kevin A., Neuhaus, Birger, and Bulnes, Ver��nica N.

Subjects
Echinorhagata, Kinorhyncha, Echinoderidae, Cyclorhagida, Echinoderes, Animalia, Biodiversity, Taxonomy, Echinoderes goku
Abstract

Echinoderes goku sp. nov. http://zoobank.org/ urn:lsid:zoobank.org:pub: 93EF677E-1755-41C7-8906-952614E71018 Diagnosis. Echinoderes with middorsal spine on segments 4, 6, and 8, and spine in lateroventral positions on segments 6���9 and 11 (lateral terminal spines). Tube present in subdorsal position on segment 2, sublateral to midlateral position on segments 7 and 9, lateral accessory position on segment 8, lateroventral position on segment 5 and ventrolateral position on segment 2. Type-2 gland cell outlets, female-specific papillae or subcuticular funnel-like structures not present. Male with a sublateral tube on segment 10 with a basal cylindrical reinforcement structure and three pairs of penile spines on segment 11. Female with sublateral fringe on surface connected with a subcuticular conical structure surrounded basally by a cylindrical reinforcement structure in segment 10 and with a lateral terminal accessory spine on segment 11. Etymology. The specific epithet is a noun in apposition and alludes to the adoptive name of the Saiyan Son Gokū, the major character from the Dragon Ball manga, authored by Akira Toriyama. Material examined. Holotype: Male (MACN-In 43755), collected on March 31, 2019 by Agust��n G. Menechella (IADO, CONICET, Argentina), at station E29 during the campaign aboard the Motorsailer ���Bernardo Houssay��� through the Argentinean continental shelf (Fig. 1), at 40 m depth using a dredge; mounted as glycerol-paraffin slide on Cobb aluminum frame. Paratypes mounted as glycerol-paraffin slides on Cobb aluminum frames: 1) material deposited at the Museo Argentino de Ciencias Naturales ���Bernardino Rivadavia���, Buenos Aires, Argentina: one male and two females (catalogue numbers MACN-In 43756a ���43756c); 2) material deposited at the Museum f��r Naturkunde Berlin, Germany, collection ���Vermes���, ���Generalkatalog freilebende W��rmer���: 12 females and 19 males (catalogue numbers ZMB 12262, 12264, 12265, 12314���12331, 12334���12344). Non-types, deposited at Museum f��r Naturkunde Berlin: four males (ZMB 12263, 12266, 12332, 12333) and five juveniles (ZMB 12267���12269, 12345��� 12347) mounted as glycerol-paraffin slides on Cobb aluminum frames and two adults of undetermined sex (ZMB 12270, 12351), one male (ZMB 12350), and four females (ZMB 12271, 12272, 12348, 12349) mounted for SEM on two stubs. All paratypes and non-types collected at same locality and date by same person as the holotype. Type locality. South West Atlantic Ocean, Argentinian continental shelf, off Pehuen-C�� and Monte Hermoso, 39��06.7���S, 061��26.5���W, 40 m depth. Description. Adults with head, neck, and 11 trunk segments (Figs 2A,B, 3A,C, 6A). For a complete overview of measures and dimensions see Table 2. Distribution of cuticular structures, i.e., sensory spots, gland cells, conical structures, spines and tubes, is summarised in Table 3. Head. Head consisting of a retractable mouth cone and an introvert (Figs 3A,C, 6A���C). Mouth cone equipped with 9 outer oral styles, each with two articulating elements and neighbouring styles slightly alternating in length (Figs 4K, 6B). Each outer oral style possessing at its base a posterior central fringe of spinose processes and one anterior lateral spinose process on each side (Fig. 6B). Posterior spinose processes may be split apically into two processes (Fig. 6B). Although two out of three specimens mounted for SEM appeared with the introvert extended, the information on scalid numbers and arrangement is scarce because of particles partially masking characters. Both odd and even-numbered sectors showing seemingly 6 spinoscalid rings (Fig. 6C). All spinoscalids composed of a broader sheath-like base with a terminal fringe of spinose processes and an articulating terminal element ending bluntly in the primary spinoscalids and spinose in rings 02���06 (Fig. 6C). Terminal element covered with short cuticular hairs. Each primary spinoscalid revealing apically on its base two prominent fringes of spinose processes (Fig. 6C). One prominent apical process also found on the basis of ring 03 spinoscalids but not on those of the following rings. Spinoscalid of ring 06 of each second sector appearing to be much smaller than that of its neighbouring sector. Six short and hairy trichoscalids with trichoscalid plates being present, opposite to the neck placids 2, 6, 8, 10, 12 and 16. Neck. Neck equipped with 16 trapezoidal placids (Figs 2A,B, 3E, 4D), wider posteriorly and with rounded edges anteriorly in SEM of at least one specimen revealing placids at full length (ZMB 12270; not shown here). In light microscopy, anterior end of each placid of almost all specimens looking as if bent partly backwards (Figs 2A,B, 3E, 4D, 5A), possibly because of the thin cuticle revealed by most specimens (see below). Midventral placid wider than the remaining ones. All placids articulating with the first trunk segment. Trichoscalid plates present on paradorsal (8 and 10), laterodorsal (6 and 12) and ventromedial (2 and 16) placids. Trunk. Segments 1 and 2 formed by a closed cuticular ring (Figs 2A,B, 4A,D, 8C) and the remaining ones by one tergal and two sternal plates (Figs 2A,B, 3E,F,J, 4A���E,I, 5A���C, 6A, 7, 8B,D���F). Midsternal and tergosternal junctions well-developed, however, the latter being less conspicuous and sometime hard to see under the light microscope. Pachycycli present anteriorly on segments 1���11 (Figs 3E,F,J, 4A���E,I,J, 5A���C). Cuticular hairs not abundant and filiform (Figs 3E,F,J, 5A���C, 6A, 7A���E, 8B���F). The bracteate hairs on segments 2���10 arranged in one or two irregular wavy rows (Figs 6A, 7A���E, 8C���F). Hairs of anterior row shorter than those of the posterior one (Figs 6A, 7A���E, 8C���F). Well-developed patch of short, stronger cuticular hairs in three rows present paraventrally and centrally on segments 3���6 (Figs 4D, 8C���E) and, less developed, also on segment 7 (Fig. 8E). Segments 4��� 10 with a ventrolateral to paraventral patch of thin cuticular hairs organised in a single or sometimes in two or three rows (Fig. 8D���F). Most adult specimens having moulted recently recognizable by differing extent of fusion of button-like structures in cuticular flap at posterior end of each segment (comp. Figs 4D,F���I, 5A, 9B,D,F���H). Primary pectinate fringe well-developed in segments 2���11 and formed by teeth usually of even length and width within a segment (Figs 3E,F,J, 4I, 5B,C, 7, 8B���F). Fringe appearing shorter on anterior three segments than in remaining segments and almost lacking dorsally on segment 10 (Fig. 7D,E), narrower ventrally on segment 10 than on remaining segments (Fig. 8F). Secondary pectinate fringe present as a single row of very short cuticular processes dorsally and ventromedially (Figs 7C, 8F). Type-1 sensory spots (Figs 2, 3E���J, 4A���D,F���I, 5A���C, 7A���E, 8C���F) and type-1 gland cell outlets (Figs 2, 3E,G,H,J, 4A,B,D���G,I, 5A,B) present. Type-2 gland cell outlets and female-specific papillae or funnel-like or pear-shaped subcuticular structures absent on any segment. Segment 1 (Figs 2A,B, 3E, 4A,D, 5A, 6A, 7A, 8C; Table 3) lacking spines and tubes. Sensory spot usually with 2 but sometimes with up to 5 pores present centrally in subdorsal, midlateral and ventromedial position, flanked by long cuticular hairs. Type-1 gland cell outlet occurring centrally in middorsal and anteriorly in lateroventral position. Other hairs than those associated with sensory spots not existing on this segment. Primary pectinate fringe as row of very short teeth with a blunt tip, broader than teeth of remaining segments. Segment 2 (Figs 2A,B, 3E, 4A,D, 5A,C, 6A, 7A, 8C; Tables 2, 3) with subdorsal and ventrolateral tube. Sensory spot present posteriorly in middorsal and midlateral position and centrally to posteriorly in ventromedial position. Type-1 gland cell outlet occurring anteriorly in middorsal and ventromedial position. Cuticular hairs scarce on this segment, but more evident if associated with the sensory spots. A few additional hairs emerging from cuticular perforation sites. Segment 3 (Figs 2A,B, 3E, 4A,D, 5A,C, 6A, 7A, 8C; Table 3) without spines and tubes. Sensory spot present posteriorly in subdorsal and sublateral position. Type-1 gland cell outlet occurring anteriorly in middorsal and centrally in ventromedial position. Cuticular hairs more abundant than on the previous segment and organised similarly on the remaining segments. Segment 4 (Figs 2A,B, 3E, 4A,D, 5A,C, 6A, 7B, 8D; Tables 2, 3) with a middorsal acicular spine. Sensory spots lacking on this segment. Type-1 gland cell outlet occurring anteriorly in paradorsal and centrally in paraventral to almost ventromedial position. Segment 5 (Figs 2A,B, 3E, 4A, 5A,C, 6A, 7B, 8D; Tables 2, 3) with lateroventral tube. Sensory spot present posteriorly in subdorsal, sublateral to midlateral position and almost centrally in ventromedial position. Sublateral to midlateral spot of segments 5 and 6 slightly more dorsally than spot of segment 3. Type-1 gland cell outlets occurring anteriorly in middorsal and centrally in paraventral to almost ventromedial position. Segment 6 (Figs 2A,B, 3F,J, 4B, 5B,C, 6A, 7B, 8D; Tables 2, 3) with middorsal and lateroventral acicular spine. Sensory spot present posteriorly in paradorsal and sublateral to midlateral position and almost centrally in ventromedial position. Type-1 gland cell outlet occurring anteriorly in paradorsal and centrally in paraventral to almost ventromedial position. Segment 7 (Figs 2A,B, 3F,J, 4B, 5B,C, 6A, 7C, 8D; Tables 2, 3) with sublateral to midlateral tube and lateroventral acicular spine. Sensory spot present posteriorly in subdorsal position and almost centrally in ventromedial position. Type-1 gland cell outlet occurring anteriorly in middorsal and paraventral to almost ventromedial position. Segment 8 (Figs 2A,B, 3F,J, 4B,I,J, 5B, 6A, 7C, 8D,E; Tables 2, 3) with a middorsal acicular spine, lateral accessory tube and lateroventral acicular spine. Middorsal spine of female much longer (92���98 ��m) than that of male (54���79 ��m) (Table 2). Sensory spot present posteriorly in paradorsal position. Type-1 gland cell outlet occurring anteriorly in paradorsal and paraventral to almost ventromedial position. Segment 9 (Figs 2, 3F,G,J, 4B,C,I,J, 5B,F,G, 6A, 7D, 8E,F; Tables 2, 3) with sublateral to midlateral tube and lateroventral acicular spine. Sensory spot present posteriorly in paradorsal and centrally in laterodorsal and ventrolateral position. Type-1 gland cell outlet occurring anteriorly in paradorsal and centrally in paraventral position. Segment 10 (Figs 2, 3G,H,J, 4B,C,E���J, 5B,D,E, 6A, 7D���F, 8B,F; Tables 2, 3) without spines but with sublateral to midlateral straight short tube with basal cuticular cylindrical reinforcement structure below trunk cuticle in male (Fig. 4F,H). Female without tube but with sublateral to midlateral subcuticular, conical structure (Figs 5D,E, 10C) ending in short apical cuticular duct through trunk cuticle, with basal cuticular cylindrical reinforcement structure below trunk cuticle (Fig. 5D,E), opening to outside via fringed pore (Fig. 7E,F). Sensory spot present posteriorly in subdorsal and ventrolateral position. Type-1 gland cell outlet occurring anteriorly in middorsal and centrally in middorsal and paraventral position. Posterior margin of each sternal plate progressing more posteriorly midventrally than lateroventrally. Segment 11 (Figs 2, 3H,I, 4F���J, 5D,E, 6A, 7D,E, 8A,B,F; Tables 2, 3) with lateral terminal spine, varying considerably in length (146���208 ��m) in both females and males (Table 2). Straight lateral terminal accessory spine present in females (Figs 2C,D, 4I,J, 5D, 6A, 7D,E, 8F; Tables 2, 3) and three penile spines appearing in males, one bent, tubular, longer, in lateral accessory position, one shorter, broader, almost triangular, slightly more dorsally, and one bent, tubular, longer sublaterally (Figs 2A,B, 4F,G, 8A; Tables 2, 3). Sensory spot present posteriorly in subdorsal position. Males often with two ventrolateral pores, unclear if belonging to a sensory spot. Two type-1 gland cell outlets occurring anteriorly and centrally behind each other in middorsal position. Tergal extensions triangular-shaped. Among the 39 specimens studied by LM and three specimens investigatable with SEM no variation of characters was found except that the position of sensory spots on segment 5 and 6 and of tubes on segments 7 and 9 varied slightly from more sublaterally to more midlaterally. Probably, one specimen (ZMB 12323) possessed a lateroventral spine only on the right side of segment 7. Juvenile stages. Five specimens could be identified as juvenile stages based on their thin trunk cuticle, the postmarginal spicula, a gap in the arrangement of cuticular hairs and postmarginal spicula about ventromedially to paraventrally where the dorsoventral muscles attach (Fig. 9B,C,E), papillate sensory spots (Fig. 10A) if present at all, the lack of recognisable gland cells, an acicular spine middorsally on segment 9 (Fig. 10A) and lateral accessorily on segment 10 (Fig. 10C), and a well developed lateral terminal accessory spine (Fig. 9A,E,F). It was not possible to identify different life history stages with certainty, because the specimens came out crumpled, twisted, and folded during mounting due to their thin cuticle. In all specimens, 11 trunk segments delimited by postmarginal spicula could be recognised, whereas sensory spots were difficult to trace. Four specimens seemed to represent late juvenile stages if not the last stage, and the fifth was moulting to a female, and this is subsequently described in more detail and documented. ......continued on the next page TABLE 2. (Continued) Last juvenile stage moulting. One specimen was fixed while moulting from the last juvenile stage to the adult stage (ZMB 12267, Fig.9A). Each of the 11 trunk segments of the juvenile specimen was covered by numerous short cuticular hairs in its central part and showed a row of postmarginal spicula posteriorly on each segment (Figs 9B���H, 10A,B). An acicular spine occurred middorsally on segments 4, 6, 8 and 9 (Figs 9H, 10A), in lateral accessory position on segments 10 (Fig. 10C) and 11 (= lateral terminal accessory spine), and lateroventrally on segments 6���9 and 11 (= lateral terminal spine) (Figs 9, 10A). A straight tube was found sublaterally on segments 7, 9 and 10 (Fig. 10B), lateral accessorily on segment 8, lateroventrally on segment 5, and ventrolaterally on segment 2. A papillate sensory spot appeared at least paradorsally on segments 6, 8 and 9 (Fig. 10A), subdorsally on segments 10 and 11 and possibly on segment 5, ventrolaterally on segments 9���11, and ventromedially on segments 1 and 5���7. The moulting adult possessed in the free flap of segments 1���10 the button-like structures, which are typical of recently moulted adults (Fig. 9B,D,G,H). The adult lacked the middorsal spine on segment 9 and the lateral accessory spine on segment 10 as well as the sublateral tube on segment 10. In the latter position, it revealed a subcuticular conical structure with a basal cuticular reinforcement structure (Fig. 10C). Additional material. A reinvestigation of sublateral to midlateral subcuticular characters in segment 10 of 14 species of Echinoderidae revealed the following results: (1) Female and male Echinoderes unispinosus unveiled a subcuticular conical structure (Fig. 5J). (2) Female and male E. meteorensis had a subcuticular very small conical structure plus a cylindrical reinforcement structure at the base of the laterodorsal tube (Fig. 5H,I). (3) Female and male E. apex possessed a subcuticular spherical structure at the base of the laterodorsal tube (Fig. 5K,L). (4) Female and male E. capitatus and E. ferrugineus expressed a subcuticular cylindrical reinforcement structure at the base of the laterodorsal tube (E. capitatus, Fig. 5F,G) or a tube was missing (E. ferrugineus, Fig. 5M). (5) Female and male E. pilosus exhibited a subcuticular reinforcement structure at the base of the laterodorsal tube plus an external cylindrical cuticular sheath surrounding the basal part of the tube (Fig. 5N). (6) Female Cephalorhyncha asiatica, Echinoderes applicitus, E. bathyalis, E. multiporus, E. pterus, Fissuroderes higgins, F. thermoi, and Polacanthoderes martinezi did not show any subcuticular structures, males were not studied., Published as part of Rucci, Kevin A., Neuhaus, Birger & Bulnes, Ver��nica N., 2022, A new species of Echinoderes (Kinorhyncha: Cyclorhagida: Echinoderidae) from the Argentinean continental shelf with notes on its postembryonic development and on subcuticular morphological characters unreported for Kinorhyncha, pp. 65-90 in Zootaxa 5099 (1) on pages 68-82, DOI: 10.11646/zootaxa.5099.1.3, http://zenodo.org/record/6036906

Published
2022
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39. Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation: The GLORIA-AF registry

Author

Ntaios, G., Huisman, M. V., Diener, H. -C., Halperin, J. L., Teutsch, C., Marler, S., Gurusamy, V. K., Thompson, M., Lip, G. Y. H., Olshansky, B., Abban, D. W., Abdul, N., Abud, A. M., Adams, F., Addala, S., Adragao, P., Ageno, W., Aggarwal, R., Agosti, S., Agostoni, P., Aguilar, F., Linares, J. A., Aguinaga, L., Ahmed, J., Aiello, A., Ainsworth, P., Aiub, J. R., Al-Dallow, R., Alderson, L., Aldrete Velasco, J. A., Alexopoulos, D., Manterola, F. A., Aliyar, P., Alonso, D., Alves da Costa, F. A., Amado, J., Amara, W., Amelot, M., Amjadi, N., Ammirati, F., Andrade, M., Andrawis, N., Annoni, G., Ansalone, G., Ariani, M. K., Arias, J. C., Armero, S., Arora, C., Aslam, M. S., Asselman, M., Audouin, P., Augenbraun, C., Aydin, S., Ayryanova, I., Aziz, E., Backes, L. M., Badings, E., Bagni, E., Baker, S. H., Bala, R., Baldi, A., Bando, S., Banerjee, S., Bank, A., Esquivias, G. B., Barr, C., Bartlett, M., Kes, V. B., Baula, G., Behrens, S., Bell, A., Benedetti, R., Mazuecos, J. B., Benhalima, B., Bergler-Klein, J., Berneau, J. -B., Bernstein, R. A., Berrospi, P., Berti, S., Berz, A., Best, E., Bettencourt, P., Betzu, R., Bhagwat, R., Bhatta, L., Biscione, F., Bisignani, G., Black, T., Bloch, M. J., Bloom, S., Blumberg, E., Bo, M., Bohmer, E., Bollmann, A., Bongiorni, M. G., Boriani, G., Boswijk, D. J., Bott, J., Bottacchi, E., Kalan, M. B., Bradman, D., Brautigam, D., Breton, N., Brouwers, P. J. A. M., Browne, K., Cortada, J. B., Bruni, A., Brunschwig, C., Buathier, H., Buhl, A., Bullinga, J., Cabrera, J. W., Caccavo, A., Cai, S., Caine, S., Calo, L., Calvi, V., Sanchez, M. C., Candeias, R., Capuano, V., Capucci, A., Caputo, R., Rizo, T. C., Cardona, F., Carlos da Costa Darrieux, F., Duarte Vera, Y. C., Carolei, A., Carreno, S., Carvalho, P., Cary, S., Casu, G., Cavallini, C., Cayla, G., Celentano, A., Cha, T. -J., Cha, K. S., Chae, J. K., Chalamidas, K., Challappa, K., Chand, S. P., Chandrashekar, H., Chartier, L., Chatterjee, K., Chavez Ayala, C. A., Cheema, A., Chen, L., Chen, S. -A., Chen, J. H., Chiang, F. -T., Chiarella, F., Chih-Chan, L., Cho, Y. K., Choi, J. -I., Choi, D. J., Chouinard, G., Hoi-Fan Chow, D., Chrysos, D., Chumakova, G., Jose Roberto Chuquiure Valenzuela, E. J., Nica, N. C., Cislowski, D. J., Clay, A., Clifford, P., Cohen, A., Cohen, M., Cohen, S., Colivicchi, F., Collins, R., Colonna, P., Compton, S., Connolly, D., Conti, A., Buenostro, G. C., Coodley, G., Cooper, M., Coronel, J., Corso, G., Sales, J. C., Cottin, Y., Covalesky, J., Cracan, A., Crea, Filippo, Crean, P., Crenshaw, J., Cullen, T., Darius, H., Dary, P., Dascotte, O., Dauber, I., Davalos, V., Davies, R., Davis, G., Davy, J. -M., Dayer, M., De Biasio, M., De Bonis, S., De Caterina, R., De Franceschi, T., de Groot, J. R., De Horta, J., De La Briolle, A., Topete, G. D. L. P., Vicenzo de Paola, A. A., de Souza, W., de Veer, A., De Wolf, L., Decoulx, E., Deepak, S., Defaye, P., Del-Carpio Munoz, F., Brkljacic, D. D., Deumite, N. J., Di Legge, S., Diemberger, I., Dietz, D., Dionisio, P., Dong, Q., Rossi dos Santos, F., Dotcheva, E., Doukky, R., D'Souza, A., Dubrey, S., Ducrocq, X., Dupljakov, D., Duque, M., Dutta, D., Duvilla, N., Duygun, A., Dziewas, R., Eaton, C. B., Eaves, W., Ebels-Tuinbeek, L. A., Ehrlich, C., Eichinger-Hasenauer, S., Eisenberg, S. J., El Jabali, A., El Shahawy, M., Hernandes, M. E., Izal, A. E., Evonich, R., Evseeva, O., Ezhov, A., Fahmy, R., Fang, Q., Farsad, R., Fauchier, L., Favale, S., Fayard, M., Fedele, J. L., Fedele, F., Fedorishina, O., Fera, S. R., Gomes Ferreira, L. G., Ferreira, J., Ferri, C., Ferrier, A., Ferro, H., Finsen, A., First, B., Fischer, S., Fonseca, C., Almeida, L. F., Forman, S., Frandsen, B., French, W., Friedman, K., Friese, A., Fruntelata, A. G., Fujii, S., Fumagalli, S., Fundamenski, M., Furukawa, Y., Gabelmann, M., Gabra, N., Gadsboll, N., Galinier, M., Gammelgaard, A., Ganeshkumar, P., Gans, C., Quintana, A. G., Gartenlaub, O., Gaspardone, A., Genz, C., Georger, F., Georges, J. -L., Georgeson, S., Giedrimas, E., Gierba, M., Ortega, I. G., Gillespie, E., Giniger, A., Giudici, M. C., Gkotsis, A., Glotzer, T. V., Gmehling, J., Gniot, J., Goethals, P., Goldbarg, S., Goldberg, R., Goldmann, B., Golitsyn, S., Gomez, S., Mesa, J. G., Gonzalez, V. B., Gonzalez Hermosillo, J. A., Gonzalez Lopez, V. M., Gorka, H., Gornick, C., Gorog, D., Gottipaty, V., Goube, P., Goudevenos, I., Graham, B., Greer, G. S., Gremmler, U., Grena, P. G., Grond, M., Gronda, E., Gronefeld, G., Gu, X., Torres Torres, I. G., Guardigli, G., Guevara, C., Guignier, A., Gulizia, M., Gumbley, M., Gunther, A., Ha, A., Hahalis, G., Hakas, J., Hall, C., Han, B., Han, S., Hargrove, J., Hargroves, D., Harris, K. B., Haruna, T., Hayek, E., Healey, J., Hearne, S., Heffernan, M., Heggelund, G., Heijmeriks, J. A., Hemels, M., Hendriks, I., Henein, S., Her, S. -H., Hermany, P., Hernandez Del Rio, J. E., Higashino, Y., Hill, M., Hisadome, T., Hishida, E., Hoffer, E., Hoghton, M., Hong, K., Hong, S. K., Horbach, S., Horiuchi, M., Hou, Y., Hsing, J., Huang, C. -H., Huckins, D., Kathy, Hughe, Huizinga, A., Hulsman, E. L., Hung, K. -C., Hwang, G. -S., Ikpoh, M., Imberti, D., Ince, H., Indolfi, C., Inoue, S., Irles, D., Iseki, H., Israel, C. N., Iteld, B., Iyer, V., Jackson-Voyzey, E., Jaffrani, N., Jager, F., James, M., Jang, S. -W., Jaramillo, N., Jarmukli, N., Jeanfreau, R. J., Jenkins, R. D., Sanchez, C. J., Jimenez, J., Jobe, R., Joen-Jakobsen, T., Jones, N., Moura Jorge, J. C., Jouve, B., Jung, B. C., Jung, K. T., Jung, W., Kachkovskiy, M., Kafkala, K., Kalinina, L., Kallmunzer, B., Kamali, F., Kamo, T., Kampus, P., Kashou, H., Kastrup, A., Katsivas, A., Kaufman, E., Kawai, K., Kawajiri, K., Kazmierski, J. F., Keeling, P., Kerr Saraiva, J. F., Ketova, G., Khaira, A. S., Khripun, A., Kim, D. -I., Kim, Y. H., Kim, N. H., Kim, D. K., Kim, J. S., Kim, K. S., Kim, J. 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M., Mollerus, M., Molon, G., Mondillo, S., Moniz, P., Mont, L., Montagud, V., Montana, O., Monti, C., Moretti, L., Mori, K., Moriarty, A., Morka, J., Moschini, L., Moschos, N., Mugge, A., Mulhearn, T. J., Muresan, C., Muriago, M., Musial, W., Musser, C. W., Musumeci, F., Nageh, T., Nakagawa, H., Nakamura, Y., Nakayama, T., Nam, G. -B., Nanna, M., Natarajan, I., Nayak, H. M., Naydenov, S., Nazli, J., Nechita, A. C., Nechvatal, L., Negron, S. A., Neiman, J., Neuenschwander, F. C., Neves, D., Neykova, A., Miguel, R. N., Nijmeh, G., Nizov, A., Campos, R. N., Nossan, J., Novikova, T., Nowalany-Kozielska, E., Nsah, E., Nunez Fragoso, J. C., Nurgalieva, S., Nuyens, D., Nyvad, O., Odin de Los Rios Ibarra, M., O'Donnell, P., O'Donnell, M., Oh, S., Oh, Y. S., Oh, D., O'Hara, G., Oikonomou, K., Olivares, C., Oliver, R., Ruiz, R. O., Olympios, C., Anna, omaszuk-Kazberuk, Asensi, J. O., eena Padayattil, Jose, Padilla Padilla, F. G., Rios, V. P., Pajes, G., Pandey, A. S., Paparella, G., Paris, F., Park, H. W., Park, J. S., Parthenakis, F., Passamonti, E., Patel, R. J., Patel, J., Patel, M., Patrick, J., Jimenez, R. P., Paz, A., Pengo, V., Pentz, W., Perez, B., Perez Rios, A. M., Perez-Cabezas, A., Perlman, R., Persic, V., Perticone, F., Peters, T. K., Petkar, S., Pezo, L. F., Pflucke, C., Pham, D. N., Phillips, R. T., Phlaum, S., Pieters, D., Pineau, J., Pinter, A., Pinto, F., Pisters, R., Pivac, N., Pocanic, D., Podoleanu, C., Politano, A., Poljakovic, Z., Pollock, S., Garcea, J. P., Poppert, H., Porcu, M., Reino, A. P., Prasad, N., Precoma, D. B., Prelle, A., Prodafikas, J., Protasov, K., Pye, M., Qiu, Z., Quedillac, J. -M., Raev, D., Raffo Grado, C. A., Rahimi, S., Raisaro, A., Rama, B., Ramos, R., Ranieri, M., Raposo, N., Rashba, E., Rauch-Kroehnert, U., Reddy, R., Renda, G., Reza, S., Ria, L., Richter, D., Rickli, H., Rieker, W., Vera, T. R., Ritt, L. E., Roberts, D., Briones, I. R., Rodriguez Escudero, A. E., Pascual, C. 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Abstract

Aim: The SAMe-TT2R2 score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently to patients with AF and SAMe-TT2R2 scores >2 than to patients with lower scores. Methods and results: We analyzed the Phase III dataset of the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF), a large, global, prospective global registry of patients with newly diagnosed AF and ≥1 stroke risk factor. We compared baseline clinical characteristics and antithrombotic prescriptions to determine the probability of the VKA prescription among anticoagulated patients with the baseline SAMe-TT2R2 score >2 and ≤ 2. Among 17,465 anticoagulated patients with AF, 4,828 (27.6%) patients were prescribed VKA and 12,637 (72.4%) patients an NOAC: 11,884 (68.0%) patients had SAMe-TT2R2 scores 0-2 and 5,581 (32.0%) patients had scores >2. The proportion of patients prescribed VKA was 28.0% among patients with SAMe-TT2R2 scores >2 and 27.5% in those with scores ≤2. Conclusions: The lack of a clear association between the SAMe-TT2R2 score and anticoagulant selection may be attributed to the relative efficacy and safety profiles between NOACs and VKAs as well as to the absence of trial evidence that an SAMe-TT2R2-guided strategy for the selection of the type of anticoagulation in NVAF patients has an impact on clinical outcomes of efficacy and safety. The latter hypothesis is currently being tested in a randomized controlled trial. Clinical trial registration: URL: https://www.clinicaltrials.gov//Unique identifier: NCT01937377, NCT01468701, and NCT01671007.

Published
2021

48. A novel approach to medical radioisotope production using inverse kinematics: A successful production test of the theranostic radionuclide 67 Cu

Author

Souliotis, G.A. Rodrigues, M.R.D. Wang, K. Iacob, V.E. Nica, N. Roeder, B. Tabacaru, G. Yu, M. Zanotti-Fregonara, P. Bonasera, A.

Abstract

A novel method for the production of important medical radioisotopes has been developed. The approach is based on performing the nuclear reaction in inverse kinematics, namely sending a heavy-ion beam of appropriate energy on a light target (e.g. H, d, He) and collecting the isotope of interest. In this work, as a proof-of-concept, we studied the production of the theranostic radionuclide 67 Cu (T 1/2 = 62 h) via the reaction of a 70 Zn beam at 15 MeV/nucleon with a hydrogen gas target. The 67 Cu radionuclide alongside other coproduced isotopes, was collected after the gas target on an aluminum catcher foil and their radioactivity was measured by off-line γ-ray analysis. After 36 h post irradiation, apart from the product of interest 67 Cu, the main radioimpurity coming from the 70 Zn + p reaction was 69m Zn (T 1/2 = 13.8 h), which can be reduced by further radio-cooling. Moreover, along with the radionuclide of interest produced in inverse kinematics, the production of additional radioisotopes is possible by making use of the forward-focused neutrons from the reaction and allowing them to interact with a secondary target. A preliminary successful test of this concept was realized in the present study. The main requirement to obtain activities appropriate for preclinical studies is the development of high-intensity heavy-ion primary beams. © 2019 Elsevier Ltd

Published
2019

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