1. Tissue-resident FOLR2+ macrophages associate with tumor-infiltrating CD8+ T cells and with increased survival of breast cancer patients
- Author
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Christian P. Bromley, Eliane Piaggio, William Vermi, André Nicolas, Jérôme Galon, Sylvain Baulande, Christine Sedlik, Charles-Antoine Dutertre, Kotsias F, Fabien Reyal, Wilfrid Richer, Nicolás Gonzalo Núñez, Pierre Guermonprez, Gerber-Ferder Y, Julie Helft, Anne Vincent-Salomon, Laetitia Lesage, Yoann Missolo-Koussou, Sophie Viel, Rodrigo Nalio Ramos, Santiago Zelenay, Emmanuel Donnadieu, Sonia Lameiras, Jordan Denizeau, Florent Ginhoux, Mattia Bugatti, Mylène Bohec, Jimena Tosello, Buttard B, Didier Meseure, Niborski Ll, Pamela Caudana, Lene Vimeux, and Institut Curie, PSL Research University, INSERM U932.
- Subjects
0303 health sciences ,education.field_of_study ,[SDV]Life Sciences [q-bio] ,Population ,Mammary gland ,Cancer ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Biology ,medicine.disease ,[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,medicine.anatomical_structure ,[SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology ,Immunity ,030220 oncology & carcinogenesis ,Cancer research ,medicine ,Cytotoxic T cell ,Macrophage ,education ,CD8 ,030304 developmental biology - Abstract
SUMMARYMacrophage infiltration is a hallmark of solid cancers and overall macrophage infiltration is correlated with lower patient survival and resistance to therapy. However, tumor-associated macrophages are phenotypically and functionally heterogeneous. Specific tumor-associated macrophage subsets might be endowed with antagonistic role on cancer progression and on the development of anti-tumor immunity. For instance, monocyte-derived TREM2+ tumor-associated macrophages have pro-tumorigenic and immunosuppressive functions. Here, we identify a discrete population of FOLR2+ tumor-associated macrophages positively correlating with patient survival in breast cancer. FOLR2+ macrophages are evolutionarily conserved across species and populate human and murine healthy mammary gland. Moreover, FOLR2+ macrophages co-localize with lymphoid aggregates containing CD8+ T cells in breast cancer and across ten other types of cancers. This study highlights antagonistic roles for tumor-associated macrophage subsets and paves the way for subset-specific therapeutic interventions in macrophages-based cancer therapies.
- Published
- 2021