1. Complex 3D microfluidic architectures formed by mechanically guided compressive buckling
- Author
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Haiwen Luan, Wubin Bai, Shulin Chen, Xinchen Ni, Xueju Wang, Zhaoqian Xie, Shenglian Yao, Yameng Xu, Heling Wang, Zhengwei Li, Jilong Ye, John A. Rogers, Tzu Li Liu, Quansan Yang, Shiwei Zhao, Di Lu, Qihui Zhang, Shuo Li, Changsheng Wu, Mengdi Han, Yeguang Xue, Kan Li, Dongwhi Choi, Jae Hwan Kim, Jan-Kai Chang, Yonggang Huang, Jean Won Kwak, Luan, Haiwen [0000-0003-0722-1108], Wang, Xueju [0000-0002-0669-8759], Zhao, Shiwei [0000-0002-9797-1334], Wang, Heling [0000-0001-7859-5153], Xue, Yeguang [0000-0002-1968-5092], Kwak, Jean Won [0000-0001-7883-9242], Bai, Wubin [0000-0003-2872-5559], Li, Kan [0000-0003-4864-3446], Ni, Xinchen [0000-0002-3327-3764], Choi, Dongwhi [0000-0002-9286-2710], Yang, Quansan [0000-0001-8029-1327], Kim, Jae-Hwan [0000-0002-8940-652X], Li, Shuo [0000-0003-4913-730X], Chang, Jan-Kai [0000-0002-3056-1250], Xie, Zhaoqian [0000-0003-1320-817X], Huang, Yonggang [0000-0002-0483-8359], Rogers, John A [0000-0002-3830-5980], and Apollo - University of Cambridge Repository
- Subjects
4003 Biomedical Engineering ,Multidisciplinary ,Materials science ,Microfluidics ,Materials Science ,SciAdv r-articles ,Bioengineering ,Nanotechnology ,46 Information and Computing Sciences ,Buckling ,Applied Sciences and Engineering ,Drug delivery ,Physical and Materials Sciences ,40 Engineering ,Biotechnology ,Research Article - Abstract
Description, Mechanically guided assembly techniques yield complex 3D microvascular networks with multifunctional characteristics., Microfluidic technologies have wide-ranging applications in chemical analysis systems, drug delivery platforms, and artificial vascular networks. This latter area is particularly relevant to 3D cell cultures, engineered tissues, and artificial organs, where volumetric capabilities in fluid distribution are essential. Existing schemes for fabricating 3D microfluidic structures are constrained in realizing desired layout designs, producing physiologically relevant microvascular structures, and/or integrating active electronic/optoelectronic/microelectromechanical components for sensing and actuation. This paper presents a guided assembly approach that bypasses these limitations to yield complex 3D microvascular structures from 2D precursors that exploit the full sophistication of 2D fabrication methods. The capabilities extend to feature sizes
- Published
- 2021