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25 results on '"Nho, Jong-Hyun"'

6. Effect of Lactobacillus casei fermented Senna tora L. seeds and its active compound via muscarinic M3 signaling on the improvement of intestinal function in rats

Author

Jang, Ji-Hun, primary, Lee, Ki-Ho, additional, Nho, Jong-Hyun, additional, Lee, Hyun-Joo, additional, Yang, Beo-Dul, additional, Park, Ho, additional, Cho, Hyun-Woo, additional, An, Byeong-Kwan, additional, Kim, Sun-Ra, additional, Yong, Ju-Hyun, additional, Park, Ro-Dong, additional, and Jung, Ho-Kyung, additional

Published
2020
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14. Effects of Eurya japonica extracts on human corneal epithelial cells and experimental dry eye.

Author

Li, Lan, Jin, Rujun, Li, Ying, Nho, Jong Hyun, Choi, Won, Ji, Yong Sok, Yoon, Hyeon Jeong, and Yoon, Kyung Chul

Subjects
DRY eye syndromes, EPITHELIAL cells, REACTIVE oxygen species, ELECTRIC batteries, EPICATECHIN, TUMOR necrosis factors
Abstract

Eurya japonica (EJ) leaves have been indicated to exert anti-oxidative and anti-inflammatory effects. Dry eye disease (DED) is a chronic inflammatory disease and oxidative stress is closely associated with DED. The aim of the present study was to analyze the therapeutic efficacy of EJ in DED using human corneal epithelial (HCE) cells and a mouse model of experimental dry eye (EDE). EJ extracts (0.001, 0.01 and 0.1%) were used to treat HCE cells. Cell viability and mitochondrial function were detected using a EZ-Cytox cell viability assay kit and mitochondrial membrane potential assays. Dichlorofluorescein diacetate (DCF-DA) assay was used to measure cellular reactive oxygen species (ROS) levels. Subsequently, eye drops consisting of BSS or 0.001%, 0.01 and 0.1% EJ extracts were applied for treatment of EDE. At 7 days, conjunctival ROS production was measured using a DCF-DA assay. Tumor necrosis factor (TNF)-α, interleukin (IL)-1β, 10 kDa interferon gamma-induced protein 10 (IP-10) and monokine induced by interferon-γ (MIG) levels in the conjunctiva were analyzed using a multiplex immunobead assay. Tear film and ocular surface parameters were measured. Treatment with EJ extracts in HCE cells effectively improved cell viability, ROS levels and mitochondrial function. Mice treated with 0.01 and 0.1% EJ extracts indicated a significant decrease in ROS, TNF-α, IL-1β, IP-10 and MIG levels compared with the EDE or BSS groups. Furthermore, a significant improvement in all clinical parameters was observed in the 0.01 and 0.1% EJ extract groups. EJ extracts could decrease cytotoxicity and ROS production in HCE cells. Additionally, topical EJ extracts reduced oxidative damage and inflammation and improved clinical signs of EDE, suggesting that EJ extracts may be used as an adjunctive therapy for DED. [ABSTRACT FROM AUTHOR]

Published
2020
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25. Beneficial Effects of Cynaroside on Cisplatin-Induced Kidney Injury In Vitroand In Vivo

Author

Nho, Jong-Hyun, Jung, Ho-Kyung, Lee, Mu-Jin, Jang, Ji-Hun, Sim, Mi-Ok, Jeong, Da-Eun, Cho, Hyun-Woo, and Kim, Jong-Choon

Abstract

Anti-cancer drugs such as cisplatin and doxorubicin are effectively used more than radiotherapy. Cisplatin is a chemotherapeutic drug, used for treatment of various forms of cancer. However, it has side effects such as ototoxicity and nephrotoxicity. Cisplatin-induced nephrotoxicity increases tubular damage and renal dysfunction. Consequently, we investigated the beneficial effect of cynaroside on cisplatin-induced kidney injury using HK-2 cell (human proximal tubule cell line) and an animal model. Results indicated that 10 µM cynaroside diminished cisplatin-induced apoptosis, mitochondrial dysfunction and caspase-3 activation, cisplatin-induced upregulation of caspase-3/MST-1 pathway decreased by treatment of cynaroside in HK-2 cells. To confirm the effect of cynaroside on cisplatin-induced kidney injury in vivo, we used cisplatin exposure animal model (20 mg/kg, balb/c mice, i.p., once a day for 3 days). Renal dysfunction, tubular damage and neutrophilia induced by cisplatin injection were decreased by cynaroside (10 mg/kg, i.p., once a day for 3 days). Results indicated that cynaroside decreased cisplatin-induced kidney injury in vitroand in vivo, and it could be used for improving cisplatin-induced side effects. However, further experiments are required regarding toxicity by high dose cynaroside and caspase-3/ MST-1-linked signal transduction in the animal model.

Published
2018
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