17 results on '"Nguyen-Tuong, N."'
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2. The SuperCam Instrument Suite on the Mars 2020 Rover: Science Objectives and Mast-Unit Description
- Author
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Maurice, S., Wiens, R. C., Bernardi, P., Caïs, P., Robinson, S., Nelson, T., Gasnault, O., Reess, J.-M., Deleuze, M., Rull, F., Manrique, J.-A., Abbaki, S., Anderson, R. B., André, Y., Angel, S. M., Arana, G., Battault, T., Beck, P., Benzerara, K., Bernard, S., Berthias, J.-P., Beyssac, O., Bonafous, M., Bousquet, B., Boutillier, M., Cadu, A., Castro, K., Chapron, F., Chide, B., Clark, K., Clavé, E., Clegg, S., Cloutis, E., Collin, C., Cordoba, E. C., Cousin, A., Dameury, J.-C., D’Anna, W., Daydou, Y., Debus, A., Deflores, L., Dehouck, E., Delapp, D., De Los Santos, G., Donny, C., Doressoundiram, A., Dromart, G., Dubois, B., Dufour, A., Dupieux, M., Egan, M., Ervin, J., Fabre, C., Fau, A., Fischer, W., Forni, O., Fouchet, T., Frydenvang, J., Gauffre, S., Gauthier, M., Gharakanian, V., Gilard, O., Gontijo, I., Gonzalez, R., Granena, D., Grotzinger, J., Hassen-Khodja, R., Heim, M., Hello, Y., Hervet, G., Humeau, O., Jacob, X., Jacquinod, S., Johnson, J. R., Kouach, D., Lacombe, G., Lanza, N., Lapauw, L., Laserna, J., Lasue, J., Le Deit, L., Le Mouélic, S., Le Comte, E., Lee, Q.-M., Legett, IV, C., Leveille, R., Lewin, E., Leyrat, C., Lopez-Reyes, G., Lorenz, R., Lucero, B., Madariaga, J. M., Madsen, S., Madsen, M., Mangold, N., Manni, F., Mariscal, J.-F., Martinez-Frias, J., Mathieu, K., Mathon, R., McCabe, K. P., McConnochie, T., McLennan, S. M., Mekki, J., Melikechi, N., Meslin, P.-Y., Micheau, Y., Michel, Y., Michel, J. M., Mimoun, D., Misra, A., Montagnac, G., Montaron, C., Montmessin, F., Moros, J., Mousset, V., Morizet, Y., Murdoch, N., Newell, R. T., Newsom, H., Nguyen Tuong, N., Ollila, A. M., Orttner, G., Oudda, L., Pares, L., Parisot, J., Parot, Y., Pérez, R., Pheav, D., Picot, L., Pilleri, P., Pilorget, C., Pinet, P., Pont, G., Poulet, F., Quantin-Nataf, C., Quertier, B., Rambaud, D., Rapin, W., Romano, P., Roucayrol, L., Royer, C., Ruellan, M., Sandoval, B. F., Sautter, V., Schoppers, M. J., Schröder, S., Seran, H.-C., Sharma, S. K., Sobron, P., Sodki, M., Sournac, A., Sridhar, V., Standarovsky, D., Storms, S., Striebig, N., Tatat, M., Toplis, M., Torre-Fdez, I., Toulemont, N., Velasco, C., Veneranda, M., Venhaus, D., Virmontois, C., Viso, M., Willis, P., and Wong, K. W.
- Published
- 2021
- Full Text
- View/download PDF
3. Extracellular Vesicle‐Based Nanodrug Delivery
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Yin, Wang, primary, Pham, Cuong V., additional, Patel, Shweta, additional, Chowdhury, Rocky, additional, Nguyen, Tuong N.‐G., additional, Tran, Phuong H.L., additional, Zhu, Yimin, additional, and Duan, Wei, additional
- Published
- 2023
- Full Text
- View/download PDF
4. The SuperCam Instrument Suite on the Mars 2020 Rover:Science Objectives and Mast-Unit Description
- Author
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Maurice, S., Wiens, R. C., Bernardi, P., Caïs, P., Robinson, S., Nelson, T., Gasnault, O., Reess, J. M., Deleuze, M., Rull, F., Manrique, J. A., Abbaki, S., Anderson, R. B., André, Y., Angel, S. M., Arana, G., Battault, T., Beck, P., Benzerara, K., Bernard, S., Berthias, J. P., Beyssac, O., Bonafous, M., Bousquet, B., Boutillier, M., Cadu, A., Castro, K., Chapron, F., Chide, B., Clark, K., Clavé, E., Clegg, S., Cloutis, E., Collin, C., Cordoba, E. C., Cousin, A., Dameury, J. C., D’Anna, W., Daydou, Y., Debus, A., Deflores, L., Dehouck, E., Delapp, D., De Los Santos, G., Donny, C., Doressoundiram, A., Dromart, G., Dubois, B., Dufour, A., Dupieux, M., Egan, M., Ervin, J., Fabre, C., Fau, A., Fischer, W., Forni, O., Fouchet, T., Frydenvang, J., Gauffre, S., Gauthier, M., Gharakanian, V., Gilard, O., Gontijo, I., Gonzalez, R., Granena, D., Grotzinger, J., Hassen-Khodja, R., Heim, M., Hello, Y., Hervet, G., Humeau, O., Jacob, X., Jacquinod, S., Johnson, J. R., Kouach, D., Lacombe, G., Lanza, N., Lapauw, L., Laserna, J., Lasue, J., Le Deit, L., Le Mouélic, S., Le Comte, E., Lee, Q. M., Legett, C., Leveille, R., Lewin, E., Leyrat, C., Lopez-Reyes, G., Lorenz, R., Lucero, B., Madariaga, J. M., Madsen, S., Madsen, M., Mangold, N., Manni, F., Mariscal, J. F., Martinez-Frias, J., Mathieu, K., Mathon, R., McCabe, K. P., McConnochie, T., McLennan, S. M., Mekki, J., Melikechi, N., Meslin, P.-Y., Micheau, Y., Michel, Y., Michel, J. M., Mimoun, D., Misra, A., Montagnac, G., Montaron, C., Montmessin, F., Moros, J., Mousset, V., Morizet, Y., Murdoch, N., Newell, R. T., Newsom, H., Nguyen Tuong, N., Ollila, A. M., Orttner, G., Oudda, L., Pares, L., Parisot, J., Parot, Y., Pérez, R., Pheav, D., Picot, L., Pilleri, P., Pilorget, C., Pinet, P., Pont, G., Poulet, F., Quantin-Nataf, C., Quertier, B., Rambaud, D., Rapin, W., Romano, P., Roucayrol, L., Royer, C., Ruellan, M., Sandoval, B. F., Sautter, V., Schoppers, M. J., Schröder, S., Seran, H. C., Sharma, S. K., Sobron, P., Sodki, M., Sournac, A., Sridhar, V., Standarovsky, D., Storms, S., Striebig, N., Tatat, M., Toplis, M., Torre-Fdez, I., Toulemont, N., Velasco, C., Veneranda, M., Venhaus, D., Virmontois, C., Viso, M., Willis, P., Wong, K. W., Maurice, S., Wiens, R. C., Bernardi, P., Caïs, P., Robinson, S., Nelson, T., Gasnault, O., Reess, J. M., Deleuze, M., Rull, F., Manrique, J. A., Abbaki, S., Anderson, R. B., André, Y., Angel, S. M., Arana, G., Battault, T., Beck, P., Benzerara, K., Bernard, S., Berthias, J. P., Beyssac, O., Bonafous, M., Bousquet, B., Boutillier, M., Cadu, A., Castro, K., Chapron, F., Chide, B., Clark, K., Clavé, E., Clegg, S., Cloutis, E., Collin, C., Cordoba, E. C., Cousin, A., Dameury, J. C., D’Anna, W., Daydou, Y., Debus, A., Deflores, L., Dehouck, E., Delapp, D., De Los Santos, G., Donny, C., Doressoundiram, A., Dromart, G., Dubois, B., Dufour, A., Dupieux, M., Egan, M., Ervin, J., Fabre, C., Fau, A., Fischer, W., Forni, O., Fouchet, T., Frydenvang, J., Gauffre, S., Gauthier, M., Gharakanian, V., Gilard, O., Gontijo, I., Gonzalez, R., Granena, D., Grotzinger, J., Hassen-Khodja, R., Heim, M., Hello, Y., Hervet, G., Humeau, O., Jacob, X., Jacquinod, S., Johnson, J. R., Kouach, D., Lacombe, G., Lanza, N., Lapauw, L., Laserna, J., Lasue, J., Le Deit, L., Le Mouélic, S., Le Comte, E., Lee, Q. M., Legett, C., Leveille, R., Lewin, E., Leyrat, C., Lopez-Reyes, G., Lorenz, R., Lucero, B., Madariaga, J. M., Madsen, S., Madsen, M., Mangold, N., Manni, F., Mariscal, J. F., Martinez-Frias, J., Mathieu, K., Mathon, R., McCabe, K. P., McConnochie, T., McLennan, S. M., Mekki, J., Melikechi, N., Meslin, P.-Y., Micheau, Y., Michel, Y., Michel, J. M., Mimoun, D., Misra, A., Montagnac, G., Montaron, C., Montmessin, F., Moros, J., Mousset, V., Morizet, Y., Murdoch, N., Newell, R. T., Newsom, H., Nguyen Tuong, N., Ollila, A. M., Orttner, G., Oudda, L., Pares, L., Parisot, J., Parot, Y., Pérez, R., Pheav, D., Picot, L., Pilleri, P., Pilorget, C., Pinet, P., Pont, G., Poulet, F., Quantin-Nataf, C., Quertier, B., Rambaud, D., Rapin, W., Romano, P., Roucayrol, L., Royer, C., Ruellan, M., Sandoval, B. F., Sautter, V., Schoppers, M. J., Schröder, S., Seran, H. C., Sharma, S. K., Sobron, P., Sodki, M., Sournac, A., Sridhar, V., Standarovsky, D., Storms, S., Striebig, N., Tatat, M., Toplis, M., Torre-Fdez, I., Toulemont, N., Velasco, C., Veneranda, M., Venhaus, D., Virmontois, C., Viso, M., Willis, P., and Wong, K. W.
- Abstract
On the NASA 2020 rover mission to Jezero crater, the remote determination of the texture, mineralogy and chemistry of rocks is essential to quickly and thoroughly characterize an area and to optimize the selection of samples for return to Earth. As part of the Perseverance payload, SuperCam is a suite of five techniques that provide critical and complementary observations via Laser-Induced Breakdown Spectroscopy (LIBS), Time-Resolved Raman and Luminescence (TRR/L), visible and near-infrared spectroscopy (VISIR), high-resolution color imaging (RMI), and acoustic recording (MIC). SuperCam operates at remote distances, primarily 2–7 m, while providing data at sub-mm to mm scales. We report on SuperCam’s science objectives in the context of the Mars 2020 mission goals and ways the different techniques can address these questions. The instrument is made up of three separate subsystems: the Mast Unit is designed and built in France; the Body Unit is provided by the United States; the calibration target holder is contributed by Spain, and the targets themselves by the entire science team. This publication focuses on the design, development, and tests of the Mast Unit; companion papers describe the other units. The goal of this work is to provide an understanding of the technical choices made, the constraints that were imposed, and ultimately the validated performance of the flight model as it leaves Earth, and it will serve as the foundation for Mars operations and future processing of the data.
- Published
- 2021
5. EChO: Exoplanet characterisation observatory
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Tinetti, G., Beaulieu, J. P., Henning, T., Meyer, M., Micela, G., Ribas, I., Stam, D., Swain, M., Krause, O., Ollivier, M., Pace, E., Swinyard, B., Aylward, A., van Boekel, R., Coradini, A., Encrenaz, T., Snellen, I., Zapatero-Osorio, M. R., Bouwman, J., Cho, J. Y-K., Coudé de Foresto, V., Guillot, T., Lopez-Morales, M., Mueller-Wodarg, I., Palle, E., Selsis, F., Sozzetti, A., Ade, P. A. R., Achilleos, N., Adriani, A., Agnor, C. B., Afonso, C., Prieto, C. Allende, Bakos, G., Barber, R. J., Barlow, M., Batista, V., Bernath, P., Bézard, B., Bordé, P., Brown, L. R., Cassan, A., Cavarroc, C., Ciaravella, A., Cockell, C., Coustenis, A., Danielski, C., Decin, L., Kok, R. De, Demangeon, O., Deroo, P., Doel, P., Drossart, P., Fletcher, L. N., Focardi, M., Forget, F., Fossey, S., Fouqué, P., Frith, J., Galand, M., Gaulme, P., Hernández, J. I. González, Grasset, O., Grassi, D., Grenfell, J. L., Griffin, M. J., Griffith, C. A., Grözinger, U., Guedel, M., Guio, P., Hainaut, O., Hargreaves, R., Hauschildt, P. H., Heng, K., Heyrovsky, D., Hueso, R., Irwin, P., Kaltenegger, L., Kervella, P., Kipping, D., Koskinen, T. T., Kovács, G., La Barbera, A., Lammer, H., Lellouch, E., Leto, G., Lopez Morales, M., Lopez Valverde, M. A., Lopez-Puertas, M., Lovis, C., Maggio, A., Maillard, J. P., Maldonado Prado, J., Marquette, J. B., Martin-Torres, F. J., Maxted, P., Miller, S., Molinari, S., Montes, D., Moro-Martin, A., Moses, J. I., Mousis, O., Nguyen Tuong, N., Nelson, R., Orton, G. S., Pantin, E., Pascale, E., Pezzuto, S., Pinfield, D., Poretti, E., Prinja, R., Prisinzano, L., Rees, J. M., Reiners, A., Samuel, B., Sánchez-Lavega, A., Forcada, J. Sanz, Sasselov, D., Savini, G., Sicardy, B., Smith, A., Stixrude, L., Strazzulla, G., Tennyson, J., Tessenyi, M., Vasisht, G., Vinatier, S., Viti, S., Waldmann, I., White, G. J., Widemann, T., Wordsworth, R., Yelle, R., Yung, Y., and Yurchenko, S. N.
- Published
- 2012
- Full Text
- View/download PDF
6. Aptamer-guided extracellular vesicle theranostics in oncology
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Tran, Phuong H-L, Xiang, Dongxi, Nguyen, Tuong N-G, Tran, Thao T-D, Chen, Qian, Yin, Wang, Zhang, Yumei, Kong, Lingxue, Duan, Andrew, Chen, Kuisheng, Sun, Miomio, Li, Yong, Hou, Yingchun, Zhu, Yimin, Ma, Yongchao, Jiang, Guoqin, Duan, Wei, Tran, Phuong H-L, Xiang, Dongxi, Nguyen, Tuong N-G, Tran, Thao T-D, Chen, Qian, Yin, Wang, Zhang, Yumei, Kong, Lingxue, Duan, Andrew, Chen, Kuisheng, Sun, Miomio, Li, Yong, Hou, Yingchun, Zhu, Yimin, Ma, Yongchao, Jiang, Guoqin, and Duan, Wei
- Abstract
In the past decade, the study of exosomes, nanosized vesicles (50-150 nm) released into the extracellular space via the fusion of multivesicular bodies with the plasma membrane, has burgeoned with impressive achievements in theranostics applications. These nanosized vesicles have emerged as key players in homeostasis and in the pathogenesis of diseases owing to the variety of the cargos they can carry, the nature of the molecules packaged inside the vesicles, and the robust interactions between exosomes and target cells or tissues. Accordingly, the development of exosome-based liquid biopsy techniques for early disease detection and for monitoring disease progression marks a new era of precision medicine in the 21st century. Moreover, exosomes possess intrinsic properties - a nanosized structure and unique "homing effects" - that make them outstanding drug delivery vehicles. In addition, targeted exosome-based drug delivery systems can be further optimized using active targeting ligands such as nucleic acid aptamers. Indeed, the aptamers themselves can function as therapeutic and/or diagnostic tools based on their attributes of unique target-binding and non-immunogenicity. This review aims to provide readers with a current picture of the research on exosomes and aptamers and their applications in cancer theranostics, highlighting recent advances in their transition from the bench to the clinic.
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- 2020
7. Aptamer-guided extracellular vesicle theranostics in oncology
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Tran, Phuong H-L, primary, Xiang, Dongxi, additional, Nguyen, Tuong N-G, additional, Tran, Thao T-D, additional, Chen, Qian, additional, Yin, Wang, additional, Zhang, Yumei, additional, Kong, Lingxue, additional, Duan, Andrew, additional, Chen, Kuisheng, additional, Sun, Miomio, additional, Li, Yong, additional, Hou, Yingchun, additional, Zhu, Yimin, additional, Ma, Yongchao, additional, Jiang, Guoqin, additional, and Duan, Wei, additional
- Published
- 2020
- Full Text
- View/download PDF
8. EChO
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Tinetti, G, Beaulieu, JP, Henning, T, Meyer, M, Micela, G, Ribas, I, Stam, D, Swain, M, Krause, O, Ollivier, M, Pace, E, Swinyard, B, Aylward, A, van Boekel, R, Coradini, A, Encrenaz, T, Snellen, I, Zapatero-Osorio, MR, Bouwman, J, Cho, JY-K, du Foresto, VC, Guillot, T, Lopez-Morales, M, Mueller-Wodarg, I, Palle, E, Selsis, F, Sozzetti, A, Ade, PAR, Achilleos, N, Adriani, A, Agnor, CB, Afonso, C, Allende Prieto, C, Bakos, G, Barber, RJ, Barlow, M, Batista, V, Bernath, P, Bezard, B, Borde, P, Brown, LR, Cassan, A, Cavarroc, C, Ciaravella, A, Cockell, C, Coustenis, A, Danielski, C, Decin, L, De Kok, R, Demangeon, O, Deroo, P, Doel, P, Drossart, P, Fletcher, LN, Focardi, M, Forget, F, Fossey, S, Fouque, P, Frith, J, Galand, M, Gaulme, P, Gonzalez Hernandez, JI, Grasset, O, Grassi, D, Grenfell, JL, Griffin, MJ, Griffith, CA, Groezinger, U, Guedel, M, Guio, P, Hainaut, O, Hargreaves, R, Hauschildt, PH, Heng, K, Heyrovsky, D, Hueso, R, Irwin, P, Kaltenegger, L, Kervella, P, Kipping, D, Koskinen, TT, Kovacs, G, La Barbera, A, Lammer, H, Lellouch, E, Leto, G, Lopez Valverde, MA, Lopez-Puertas, M, Lovis, C, Maggio, A, Maillard, JP, Maldonado Prado, J, Marquette, JB, Martin-Torres, FJ, Maxted, P, Miller, S, Molinari, S, Montes, D, Moro-Martin, A, Moses, JI, Mousis, O, Nguyen Tuong, N, Nelson, R, Orton, GS, Pantin, E, Pascale, E, Pezzuto, S, Pinfield, D, Poretti, E, Prinja, R, Prisinzano, L, Rees, JM, Reiners, A, Samuel, B, Sanchez-Lavega, A, Sanz Forcada, J, Sasselov, D, Savini, G, Sicardy, B, Smith, A, Stixrude, L, Strazzulla, G, Tennyson, J, Tessenyi, M, Vasisht, G, Vinatier, S, Viti, S, Waldmann, I, White, GJ, Widemann, T, Wordsworth, R, Yelle, R, Yung, Y, and Yurchenko, SN
- Subjects
Science & Technology ,Exoplanets ,EARTH-LIKE PLANETS ,MU-M ,Astronomy & Astrophysics ,M-DWARFS ,ATMOSPHERE ,Space mission ,EXOPLANET HD 209458B ,0201 Astronomical And Space Sciences ,Physical Sciences ,astro-ph.EP ,UPSILON ANDROMEDAE B ,TRANSMISSION SPECTRUM ,PHASE CURVE ,189733B ,TRANSITING EXTRASOLAR PLANET ,Planetary atmospheres ,astro-ph.IM - Published
- 2012
9. EChO
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Tinetti, G., Beaulieu, J. P., Henning, T., Meyer, M., Micela, G., Ribas, I., Stam, D., Swain, M., Krause, O., Ollivier, M., Pace, E., Swinyard, B., Aylward, A., van Boekel, R., Coradini, A., Encrenaz, T., Snellen, I., Zapatero-Osorio, M. R., Bouwman, J., Cho, J. Y-K., Coudé de Foresto, V., Guillot, T., Lopez-Morales, M., Mueller-Wodarg, I., Palle, E., Selsis, F., Sozzetti, A., Ade, P. A. R., Achilleos, N., Adriani, A., Agnor, C. B., Afonso, C., Prieto, C. Allende, Bakos, G., Barber, R. J., Barlow, M., Batista, V., Bernath, P., Bézard, B., Bordé, P., Brown, L. R., Cassan, A., Cavarroc, C., Ciaravella, A., Cockell, C., Coustenis, A., Danielski, C., Decin, L., Kok, R. De, Demangeon, O., Deroo, P., Doel, P., Drossart, P., Fletcher, L. N., Focardi, M., Forget, F., Fossey, S., Fouqué, P., Frith, J., Galand, M., Gaulme, P., Hernández, J. I. González, Grasset, O., Grassi, D., Grenfell, J. L., Griffin, M. J., Griffith, C. A., Grözinger, U., Guedel, M., Guio, P., Hainaut, O., Hargreaves, R., Hauschildt, P. H., Heng, Kevin, Heyrovsky, D., Hueso, R., Irwin, P., Kaltenegger, L., Kervella, P., Kipping, D., Koskinen, T. T., Kovács, G., La Barbera, A., Lammer, H., Lellouch, E., Leto, G., Lopez Morales, M., Lopez Valverde, M. A., Lopez-Puertas, M., Lovis, C., Maggio, A., Maillard, J. P., Maldonado Prado, J., Marquette, J. B., Martin-Torres, F. J., Maxted, P., Miller, S., Molinari, S., Montes, D., Moro-Martin, A., Moses, J. I., Mousis, O., Nguyen Tuong, N., Nelson, R., Orton, G. S., Pantin, E., Pascale, E., Pezzuto, S., Pinfield, D., Poretti, E., Prinja, R., Prisinzano, L., Rees, J. M., Reiners, A., Samuel, B., Sánchez-Lavega, A., Forcada, J. Sanz, Sasselov, D., Savini, G., Sicardy, B., Smith, A., Stixrude, L., Strazzulla, G., Tennyson, J., Tessenyi, M., Vasisht, G., Vinatier, S., Viti, S., Waldmann, I., White, G. J., Widemann, T., Wordsworth, R., Yelle, R., Yung, Y., and Yurchenko, S. N.
- Subjects
530 Physics ,520 Astronomy ,Astrophysics::Earth and Planetary Astrophysics - Abstract
A dedicated mission to investigate exoplanetary atmospheres represents a major milestone in our quest to understand our place in the universe by placing our Solar System in context and by addressing the suitability of planets for the presence of life. EChO—the Exoplanet Characterisation Observatory—is a mission concept specifically geared for this purpose. EChO will provide simultaneous, multi-wavelength spectroscopic observations on a stable platform that will allow very long exposures. The use of passive cooling, few moving parts and well established technology gives a low-risk and potentially long-lived mission. EChO will build on observations by Hubble, Spitzer and ground-based telescopes, which discovered the first molecules and atoms in exoplanetary atmospheres. However, EChO’s configuration and specifications are designed to study a number of systems in a consistent manner that will eliminate the ambiguities affecting prior observations. EChO will simultaneously observe a broad enough spectral region—from the visible to the mid-infrared—to constrain from one single spectrum the temperature structure of the atmosphere, the abundances of the major carbon and oxygen bearing species, the expected photochemically-produced species and magnetospheric signatures. The spectral range and resolution are tailored to separate bands belonging to up to 30 molecules and retrieve the composition and temperature structure of planetary atmospheres. The target list for EChO includes planets ranging from Jupiter-sized with equilibrium temperatures T eq up to 2,000 K, to those of a few Earth masses, with T eq \u223c 300 K. The list will include planets with no Solar System analog, such as the recently discovered planets GJ1214b, whose density lies between that of terrestrial and gaseous planets, or the rocky-iron planet 55 Cnc e, with day-side temperature close to 3,000 K. As the number of detected exoplanets is growing rapidly each year, and the mass and radius of those detected steadily decreases, the target list will be constantly adjusted to include the most interesting systems. We have baselined a dispersive spectrograph design covering continuously the 0.4–16 μm spectral range in 6 channels (1 in the visible, 5 in the InfraRed), which allows the spectral resolution to be adapted from several tens to several hundreds, depending on the target brightness. The instrument will be mounted behind a 1.5 m class telescope, passively cooled to 50 K, with the instrument structure and optics passively cooled to \u223c45 K. EChO will be placed in a grand halo orbit around L2. This orbit, in combination with an optimised thermal shield design, provides a highly stable thermal environment and a high degree of visibility of the sky to observe repeatedly several tens of targets over the year. Both the baseline and alternative designs have been evaluated and no critical items with Technology Readiness Level (TRL) less than 4–5 have been identified. We have also undertaken a first-order cost and development plan analysis and find that EChO is easily compatible with the ESA M-class mission framework.
- Published
- 2012
- Full Text
- View/download PDF
10. The mid-infrared channel of the EChO mission
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Reess, J. M., additional, Tinetti, G., additional, Beaulieu, J. P., additional, Bernardi, P., additional, Boulade, O., additional, Cara, C., additional, Coudé de Foresto, V., additional, Drossart, P., additional, Lagage, P. O., additional, Morinaud, G., additional, Nguyen-Tuong, N., additional, Ollivier, M., additional, Pinsard, F., additional, Tanrin, J., additional, Zeganadin, D., additional, and Cledassou, R., additional
- Published
- 2014
- Full Text
- View/download PDF
11. EChO
- Author
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Tinetti, G., primary, Beaulieu, J. P., additional, Henning, T., additional, Meyer, M., additional, Micela, G., additional, Ribas, I., additional, Stam, D., additional, Swain, M., additional, Krause, O., additional, Ollivier, M., additional, Pace, E., additional, Swinyard, B., additional, Aylward, A., additional, van Boekel, R., additional, Coradini, A., additional, Encrenaz, T., additional, Snellen, I., additional, Zapatero-Osorio, M. R., additional, Bouwman, J., additional, Cho, J. Y-K., additional, Coudé de Foresto, V., additional, Guillot, T., additional, Lopez-Morales, M., additional, Mueller-Wodarg, I., additional, Palle, E., additional, Selsis, F., additional, Sozzetti, A., additional, Ade, P. A. R., additional, Achilleos, N., additional, Adriani, A., additional, Agnor, C. B., additional, Afonso, C., additional, Prieto, C. Allende, additional, Bakos, G., additional, Barber, R. J., additional, Barlow, M., additional, Batista, V., additional, Bernath, P., additional, Bézard, B., additional, Bordé, P., additional, Brown, L. R., additional, Cassan, A., additional, Cavarroc, C., additional, Ciaravella, A., additional, Cockell, C., additional, Coustenis, A., additional, Danielski, C., additional, Decin, L., additional, Kok, R. De, additional, Demangeon, O., additional, Deroo, P., additional, Doel, P., additional, Drossart, P., additional, Fletcher, L. N., additional, Focardi, M., additional, Forget, F., additional, Fossey, S., additional, Fouqué, P., additional, Frith, J., additional, Galand, M., additional, Gaulme, P., additional, Hernández, J. I. González, additional, Grasset, O., additional, Grassi, D., additional, Grenfell, J. L., additional, Griffin, M. J., additional, Griffith, C. A., additional, Grözinger, U., additional, Guedel, M., additional, Guio, P., additional, Hainaut, O., additional, Hargreaves, R., additional, Hauschildt, P. H., additional, Heng, K., additional, Heyrovsky, D., additional, Hueso, R., additional, Irwin, P., additional, Kaltenegger, L., additional, Kervella, P., additional, Kipping, D., additional, Koskinen, T. T., additional, Kovács, G., additional, La Barbera, A., additional, Lammer, H., additional, Lellouch, E., additional, Leto, G., additional, Lopez Morales, M., additional, Lopez Valverde, M. A., additional, Lopez-Puertas, M., additional, Lovis, C., additional, Maggio, A., additional, Maillard, J. P., additional, Maldonado Prado, J., additional, Marquette, J. B., additional, Martin-Torres, F. J., additional, Maxted, P., additional, Miller, S., additional, Molinari, S., additional, Montes, D., additional, Moro-Martin, A., additional, Moses, J. I., additional, Mousis, O., additional, Nguyen Tuong, N., additional, Nelson, R., additional, Orton, G. S., additional, Pantin, E., additional, Pascale, E., additional, Pezzuto, S., additional, Pinfield, D., additional, Poretti, E., additional, Prinja, R., additional, Prisinzano, L., additional, Rees, J. M., additional, Reiners, A., additional, Samuel, B., additional, Sánchez-Lavega, A., additional, Forcada, J. Sanz, additional, Sasselov, D., additional, Savini, G., additional, Sicardy, B., additional, Smith, A., additional, Stixrude, L., additional, Strazzulla, G., additional, Tennyson, J., additional, Tessenyi, M., additional, Vasisht, G., additional, Vinatier, S., additional, Viti, S., additional, Waldmann, I., additional, White, G. J., additional, Widemann, T., additional, Wordsworth, R., additional, Yelle, R., additional, Yung, Y., additional, and Yurchenko, S. N., additional
- Published
- 2012
- Full Text
- View/download PDF
12. The mid-infrared channel of the EChO mission
- Author
-
Oschmann, Jacobus M., Clampin, Mark, Fazio, Giovanni G., MacEwen, Howard A., Reess, J. M., Tinetti, G., Beaulieu, J. P., Bernardi, P., Boulade, O., Cara, C., Coudé de Foresto, V., Drossart, P., Lagage, P. O., Morinaud, G., Nguyen-Tuong, N., Ollivier, M., Pinsard, F., Tanrin, J., Zeganadin, D., and Cledassou, R.
- Published
- 2014
- Full Text
- View/download PDF
13. EChO: Exoplanet characterisation observatory
- Author
-
Tinetti, G., Beaulieu, J. P., Henning, T., Meyer, M., Micela, G., Ribas, I., Stam, D., Swain, M., Krause, O., Ollivier, M., Pace, E., Swinyard, B., Aylward, A., van Boekel, R., Coradini, A., Encrenaz, T., Snellen, I., Zapatero-Osorio, M. R., Bouwman, J., Cho, J. Y-K., Coudé du Foresto, V., Guillot, T., Lopez-Morales, M., Mueller-Wodarg, I., Palle, E., Selsis, F., Sozzetti, A., Ade, P. A. R., Achilleos, N., Adriani, A., Agnor, C. B., Afonso, C., Allende Prieto, C., Bakos, G., Barber, R. J., Barlow, M., Batista, V., Bernath, P., Bézard, B., Bordé, P., Brown, L. R., Cassan, A., Cavarroc, C., Ciaravella, A., Cockell, C., Coustenis, A., Danielski, C., Decin, L., De Kok, R., Demangeon, O., Deroo, P., Doel, P., Drossart, P., Fletcher, L. N., Focardi, M., Forget, F., Fossey, S., Fouqué, P., Frith, J., Galand, M., Gaulme, P., González Hernández, J. I., Grasset, O., Grassi, D., Grenfell, J. L., Griffin, M. J., Griffith, C. A., Grözinger, U., Guedel, M., Guio, P., Hainaut, O., Hargreaves, R., Hauschildt, P. H., Heng, K., Heyrovsky, D., Hueso, R., Irwin, P., Kaltenegger, L., Kervella, P., Kipping, D., Koskinen, T. T., Kovács, G., La Barbera, A., Lammer, H., Lellouch, E., Leto, G., Lopez Valverde, M. A., Lopez-Puertas, M., Lovis, C., Maggio, A., Maillard, J. P., Maldonado Prado, J., Marquette, J. B., Martin-Torres, F. J., Maxted, P., Miller, S., Molinari, S., Montes, D., Moro-Martin, A., Moses, J. I., Mousis, O., Nguyen Tuong, N., Nelson, R., Orton, G. S., Pantin, E., Pascale, E., Pezzuto, S., Pinfield, D., Poretti, E., Prinja, R., Prisinzano, L., Rees, J. M., Reiners, A., Samuel, B., Sánchez-Lavega, A., Sanz Forcada, J., Sasselov, D., Savini, G., Sicardy, B., Smith, A., Stixrude, L., Strazzulla, G., Tennyson, J., Tessenyi, M., Vasisht, G., Vinatier, S., Viti, S., Waldmann, I., White, G. J., Widemann, T., Wordsworth, R., Yelle, R., Yung, Y., Yurchenko, S. N., Tinetti, G., Beaulieu, J. P., Henning, T., Meyer, M., Micela, G., Ribas, I., Stam, D., Swain, M., Krause, O., Ollivier, M., Pace, E., Swinyard, B., Aylward, A., van Boekel, R., Coradini, A., Encrenaz, T., Snellen, I., Zapatero-Osorio, M. R., Bouwman, J., Cho, J. Y-K., Coudé du Foresto, V., Guillot, T., Lopez-Morales, M., Mueller-Wodarg, I., Palle, E., Selsis, F., Sozzetti, A., Ade, P. A. R., Achilleos, N., Adriani, A., Agnor, C. B., Afonso, C., Allende Prieto, C., Bakos, G., Barber, R. J., Barlow, M., Batista, V., Bernath, P., Bézard, B., Bordé, P., Brown, L. R., Cassan, A., Cavarroc, C., Ciaravella, A., Cockell, C., Coustenis, A., Danielski, C., Decin, L., De Kok, R., Demangeon, O., Deroo, P., Doel, P., Drossart, P., Fletcher, L. N., Focardi, M., Forget, F., Fossey, S., Fouqué, P., Frith, J., Galand, M., Gaulme, P., González Hernández, J. I., Grasset, O., Grassi, D., Grenfell, J. L., Griffin, M. J., Griffith, C. A., Grözinger, U., Guedel, M., Guio, P., Hainaut, O., Hargreaves, R., Hauschildt, P. H., Heng, K., Heyrovsky, D., Hueso, R., Irwin, P., Kaltenegger, L., Kervella, P., Kipping, D., Koskinen, T. T., Kovács, G., La Barbera, A., Lammer, H., Lellouch, E., Leto, G., Lopez Valverde, M. A., Lopez-Puertas, M., Lovis, C., Maggio, A., Maillard, J. P., Maldonado Prado, J., Marquette, J. B., Martin-Torres, F. J., Maxted, P., Miller, S., Molinari, S., Montes, D., Moro-Martin, A., Moses, J. I., Mousis, O., Nguyen Tuong, N., Nelson, R., Orton, G. S., Pantin, E., Pascale, E., Pezzuto, S., Pinfield, D., Poretti, E., Prinja, R., Prisinzano, L., Rees, J. M., Reiners, A., Samuel, B., Sánchez-Lavega, A., Sanz Forcada, J., Sasselov, D., Savini, G., Sicardy, B., Smith, A., Stixrude, L., Strazzulla, G., Tennyson, J., Tessenyi, M., Vasisht, G., Vinatier, S., Viti, S., Waldmann, I., White, G. J., Widemann, T., Wordsworth, R., Yelle, R., Yung, Y., and Yurchenko, S. N.
- Abstract
A dedicated mission to investigate exoplanetary atmospheres represents a major milestone in our quest to understand our place in the universe by placing our Solar System in context and by addressing the suitability of planets for the presence of life. EChO—the Exoplanet Characterisation Observatory—is a mission concept specifically geared for this purpose. EChO will provide simultaneous, multi-wavelength spectroscopic observations on a stable platform that will allow very long exposures. The use of passive cooling, few moving parts and well established technology gives a low-risk and potentially long-lived mission. EChO will build on observations by Hubble, Spitzer and ground-based telescopes, which discovered the first molecules and atoms in exoplanetary atmospheres. However, EChO's configuration and specifications are designed to study a number of systems in a consistent manner that will eliminate the ambiguities affecting prior observations. EChO will simultaneously observe a broad enough spectral region—from the visible to the mid-infrared—to constrain from one single spectrum the temperature structure of the atmosphere, the abundances of the major carbon and oxygen bearing species, the expected photochemically-produced species and magnetospheric signatures. The spectral range and resolution are tailored to separate bands belonging to up to 30 molecules and retrieve the composition and temperature structure of planetary atmospheres. The target list for EChO includes planets ranging from Jupiter-sized with equilibrium temperatures T eq up to 2,000 K, to those of a few Earth masses, with T eq ~ 300 K. The list will include planets with no Solar System analog, such as the recently discovered planets GJ1214b, whose density lies between that of terrestrial and gaseous planets, or the rocky-iron planet 55 Cnc e, with day-side temperature close to 3,000 K. As the number of detected exoplanets is
14. EChO: Exoplanet characterisation observatory
- Author
-
Tinetti, G., Beaulieu, J. P., Henning, T., Meyer, M., Micela, G., Ribas, I., Stam, D., Swain, M., Krause, O., Ollivier, M., Pace, E., Swinyard, B., Aylward, A., van Boekel, R., Coradini, A., Encrenaz, T., Snellen, I., Zapatero-Osorio, M. R., Bouwman, J., Cho, J. Y-K., Coudé du Foresto, V., Guillot, T., Lopez-Morales, M., Mueller-Wodarg, I., Palle, E., Selsis, F., Sozzetti, A., Ade, P. A. R., Achilleos, N., Adriani, A., Agnor, C. B., Afonso, C., Allende Prieto, C., Bakos, G., Barber, R. J., Barlow, M., Batista, V., Bernath, P., Bézard, B., Bordé, P., Brown, L. R., Cassan, A., Cavarroc, C., Ciaravella, A., Cockell, C., Coustenis, A., Danielski, C., Decin, L., De Kok, R., Demangeon, O., Deroo, P., Doel, P., Drossart, P., Fletcher, L. N., Focardi, M., Forget, F., Fossey, S., Fouqué, P., Frith, J., Galand, M., Gaulme, P., González Hernández, J. I., Grasset, O., Grassi, D., Grenfell, J. L., Griffin, M. J., Griffith, C. A., Grözinger, U., Guedel, M., Guio, P., Hainaut, O., Hargreaves, R., Hauschildt, P. H., Heng, K., Heyrovsky, D., Hueso, R., Irwin, P., Kaltenegger, L., Kervella, P., Kipping, D., Koskinen, T. T., Kovács, G., La Barbera, A., Lammer, H., Lellouch, E., Leto, G., Lopez Valverde, M. A., Lopez-Puertas, M., Lovis, C., Maggio, A., Maillard, J. P., Maldonado Prado, J., Marquette, J. B., Martin-Torres, F. J., Maxted, P., Miller, S., Molinari, S., Montes, D., Moro-Martin, A., Moses, J. I., Mousis, O., Nguyen Tuong, N., Nelson, R., Orton, G. S., Pantin, E., Pascale, E., Pezzuto, S., Pinfield, D., Poretti, E., Prinja, R., Prisinzano, L., Rees, J. M., Reiners, A., Samuel, B., Sánchez-Lavega, A., Sanz Forcada, J., Sasselov, D., Savini, G., Sicardy, B., Smith, A., Stixrude, L., Strazzulla, G., Tennyson, J., Tessenyi, M., Vasisht, G., Vinatier, S., Viti, S., Waldmann, I., White, G. J., Widemann, T., Wordsworth, R., Yelle, R., Yung, Y., Yurchenko, S. N., Tinetti, G., Beaulieu, J. P., Henning, T., Meyer, M., Micela, G., Ribas, I., Stam, D., Swain, M., Krause, O., Ollivier, M., Pace, E., Swinyard, B., Aylward, A., van Boekel, R., Coradini, A., Encrenaz, T., Snellen, I., Zapatero-Osorio, M. R., Bouwman, J., Cho, J. Y-K., Coudé du Foresto, V., Guillot, T., Lopez-Morales, M., Mueller-Wodarg, I., Palle, E., Selsis, F., Sozzetti, A., Ade, P. A. R., Achilleos, N., Adriani, A., Agnor, C. B., Afonso, C., Allende Prieto, C., Bakos, G., Barber, R. J., Barlow, M., Batista, V., Bernath, P., Bézard, B., Bordé, P., Brown, L. R., Cassan, A., Cavarroc, C., Ciaravella, A., Cockell, C., Coustenis, A., Danielski, C., Decin, L., De Kok, R., Demangeon, O., Deroo, P., Doel, P., Drossart, P., Fletcher, L. N., Focardi, M., Forget, F., Fossey, S., Fouqué, P., Frith, J., Galand, M., Gaulme, P., González Hernández, J. I., Grasset, O., Grassi, D., Grenfell, J. L., Griffin, M. J., Griffith, C. A., Grözinger, U., Guedel, M., Guio, P., Hainaut, O., Hargreaves, R., Hauschildt, P. H., Heng, K., Heyrovsky, D., Hueso, R., Irwin, P., Kaltenegger, L., Kervella, P., Kipping, D., Koskinen, T. T., Kovács, G., La Barbera, A., Lammer, H., Lellouch, E., Leto, G., Lopez Valverde, M. A., Lopez-Puertas, M., Lovis, C., Maggio, A., Maillard, J. P., Maldonado Prado, J., Marquette, J. B., Martin-Torres, F. J., Maxted, P., Miller, S., Molinari, S., Montes, D., Moro-Martin, A., Moses, J. I., Mousis, O., Nguyen Tuong, N., Nelson, R., Orton, G. S., Pantin, E., Pascale, E., Pezzuto, S., Pinfield, D., Poretti, E., Prinja, R., Prisinzano, L., Rees, J. M., Reiners, A., Samuel, B., Sánchez-Lavega, A., Sanz Forcada, J., Sasselov, D., Savini, G., Sicardy, B., Smith, A., Stixrude, L., Strazzulla, G., Tennyson, J., Tessenyi, M., Vasisht, G., Vinatier, S., Viti, S., Waldmann, I., White, G. J., Widemann, T., Wordsworth, R., Yelle, R., Yung, Y., and Yurchenko, S. N.
- Abstract
A dedicated mission to investigate exoplanetary atmospheres represents a major milestone in our quest to understand our place in the universe by placing our Solar System in context and by addressing the suitability of planets for the presence of life. EChO—the Exoplanet Characterisation Observatory—is a mission concept specifically geared for this purpose. EChO will provide simultaneous, multi-wavelength spectroscopic observations on a stable platform that will allow very long exposures. The use of passive cooling, few moving parts and well established technology gives a low-risk and potentially long-lived mission. EChO will build on observations by Hubble, Spitzer and ground-based telescopes, which discovered the first molecules and atoms in exoplanetary atmospheres. However, EChO's configuration and specifications are designed to study a number of systems in a consistent manner that will eliminate the ambiguities affecting prior observations. EChO will simultaneously observe a broad enough spectral region—from the visible to the mid-infrared—to constrain from one single spectrum the temperature structure of the atmosphere, the abundances of the major carbon and oxygen bearing species, the expected photochemically-produced species and magnetospheric signatures. The spectral range and resolution are tailored to separate bands belonging to up to 30 molecules and retrieve the composition and temperature structure of planetary atmospheres. The target list for EChO includes planets ranging from Jupiter-sized with equilibrium temperatures T eq up to 2,000 K, to those of a few Earth masses, with T eq ~ 300 K. The list will include planets with no Solar System analog, such as the recently discovered planets GJ1214b, whose density lies between that of terrestrial and gaseous planets, or the rocky-iron planet 55 Cnc e, with day-side temperature close to 3,000 K. As the number of detected exoplanets is
- Full Text
- View/download PDF
15. Aspirin-loaded nanoexosomes as cancer therapeutics.
- Author
-
Tran PHL, Wang T, Yin W, Tran TTD, Nguyen TNG, Lee BJ, and Duan W
- Subjects
- Animals, Antineoplastic Agents administration & dosage, Apoptosis drug effects, Aspirin administration & dosage, Aspirin chemistry, Autophagy drug effects, Breast Neoplasms metabolism, Breast Neoplasms pathology, Colorectal Neoplasms metabolism, Colorectal Neoplasms pathology, Endocytosis, Female, HT29 Cells, Humans, Mice, Inbred NOD, Mice, SCID, Neoplastic Stem Cells metabolism, Neoplastic Stem Cells pathology, Tissue Distribution, Xenograft Model Antitumor Assays, Antineoplastic Agents pharmacology, Aspirin pharmacology, Breast Neoplasms drug therapy, Colorectal Neoplasms drug therapy, Drug Carriers, Drug Delivery Systems instrumentation, Exosomes metabolism, Nanoparticles, Neoplastic Stem Cells drug effects
- Abstract
The long history of discovery and recently encouraging studies of the anti-cancer effect of aspirin promise a closer step to widely used aspirin-based medication in cancer therapy. To resolve the poor water-solubility of aspirin and low encapsulation efficiency of exosomes for further developing a new delivery of aspirin as anti-cancer treatment, our nanoamorphous exosomal delivery platform was established. In this study, the anti-tumour effects of nanoamorphous aspirin-loaded exosomes with exosomes derived from breast and colorectal cancer cells, were comprehensively studied using both in vitro and in vivo models. These exosomes displayed enhanced cellular uptake via both clathrin-dependent and -independent endocytosis pathways, and significantly improved cytotoxicity of aspirin to breast and colorectal cancer cells, accompanied by the enhanced apoptosis and autophagy. Remarkably, this nanoamorphous exosomal platform endowed aspirin with the unprecedented cancer stem cell eradication capacity. Further animal study demonstrated that this developed exosomal system was able to efficiently deliver aspirin to in vivo tumours. The active targeting of these exosomes to tumour was further improved by conjugating an aptamer specifically targeting EpCAM protein. Hence, this nanoamorphous structured exosome system effectively transformed aspirin into a potential cancer stem cell killer with distinguished properties for clinical translation., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
16. Development of a nanoamorphous exosomal delivery system as an effective biological platform for improved encapsulation of hydrophobic drugs.
- Author
-
Tran PHL, Wang T, Yin W, Tran TTD, Barua HT, Zhang Y, Midge SB, Nguyen TNG, Lee BJ, and Duan W
- Subjects
- Breast Neoplasms drug therapy, Cell Line, Tumor, Cell Survival drug effects, Colorectal Neoplasms drug therapy, Epoxy Compounds administration & dosage, Humans, Hydrophobic and Hydrophilic Interactions, Poloxamer administration & dosage, Vitamin E administration & dosage, Antineoplastic Agents administration & dosage, Aspirin administration & dosage, Drug Delivery Systems, Exosomes
- Abstract
Despite their great potential, the nano-sized extracellular vesicles are yet to become effective delivery systems for poorly water-soluble drugs. Here, we present a novel platform of exosomes as a drug delivery system by engineering of a poorly water-soluble drug into a poloxamer-based molecular nanostructured dispersion composed of a hydrophilic and a hydrophobic moiety for an enhanced anticancer efficacy. For the first time, aspirin was loaded into exosomes as an anticancer agent via a one-step fabrication combining the nano-matrix formation of the nanostructured dispersion and exosomes loading. Our approach could transform crystalline aspirin to a nanoamorphous form in the nano-matrix structured exosomes, leading to increased drug encapsulation efficiency for exosomes, improved dissolution and strongly enhanced cytotoxicity of aspirin to cancer cells. Interestingly, cytotoxicity of aspirin to both breast and colorectal cancer cells could be strongly enhanced by the nanoamorphous aspirin-loaded exosomes, and this cytotoxic effect was more pronounced to parental cells of the exosomes, reminiscent of homing effect. Hence, this study has pioneered a novel nanoplatform of nanoamorphous exosomal delivery system to transform an anti-inflammatory drug into a potent anti-cancer agent., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
17. Nanoprecipitation for Poorly Water-Soluble Drugs.
- Author
-
Nguyen TNG, Tran VT, Duan W, Tran PHL, and Tran TTD
- Subjects
- Chemical Precipitation, Solubility, Water chemistry, Nanoparticles chemistry, Pharmaceutical Preparations chemistry
- Abstract
Background: More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects., Methods: Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up., Results: However, there are two technical issues of concern related to this method. First, the two solvents used for this approach must be miscible; concomitantly, the drug has to be soluble enough in a solvent but not in the antisolvent. Second, the particle growth needs to be adjusted by surfactant addition., Conclusion: In this review, nanoprecipitation methods and solvent removal techniques for poorly water soluble drugs will be discussed., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Published
- 2017
- Full Text
- View/download PDF
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