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16 results on '"Nguyen, Zachary"'

4. Bioelectrocatalytic Synthesis: Concepts and Applications.

Author

Boucher, Dylan G., Carroll, Emily, Nguyen, Zachary A., Jadhav, Rohit G., Simoska, Olja, Beaver, Kevin, and Minteer, Shelley D.

Subjects
ELECTROSYNTHESIS, BIOCATALYSIS, ELECTRICAL energy, ENERGY conversion, ENZYMES, ELECTROCATALYSIS
Abstract

Bioelectrocatalytic synthesis is the conversion of electrical energy into value‐added products using biocatalysts. These methods merge the specificity and selectivity of biocatalysis and energy‐related electrocatalysis to address challenges in the sustainable synthesis of pharmaceuticals, commodity chemicals, fuels, feedstocks and fertilizers. However, the specialized experimental setups and domain knowledge for bioelectrocatalysis pose a significant barrier to adoption. This review introduces key concepts of bioelectrosynthetic systems. We provide a tutorial on the methods of biocatalyst utilization, the setup of bioelectrosynthetic cells, and the analytical methods for assessing bioelectrocatalysts. Key applications of bioelectrosynthesis in ammonia production and small‐molecule synthesis are outlined for both enzymatic and microbial systems. This review serves as a necessary introduction and resource for the non‐specialist interested in bioelectrosynthetic research. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Electrofuels: general discussion

Author

Ashraf, Talal, primary, Avanthay, Mickaël, additional, Batanero, Belen, additional, Bondue, Christoph, additional, Boucher, Dylan G., additional, Gerulskis, Rokas, additional, Kuhn, Alexander, additional, Minteer, Shelley D., additional, Mount, Andrew, additional, Nguyen, Zachary A., additional, Price, Robert, additional, Rasul, Shahid, additional, Shida, Naoki, additional, Sokalu, Eniola, additional, and Tan, Jeannie Z. Y., additional

Published
2023
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8. Understanding and controlling organic electrosynthesis mechanism: general discussion

Author

Avanthay, Mickaël, primary, Batanero, Belen, additional, Bondue, Christoph, additional, Boucher, Dylan G., additional, Broersen, Pim, additional, Brown, Richard C. D., additional, Chen, Luke, additional, Choi, Anthony, additional, Fong, Ching Wai, additional, Fuchigami, Toshio, additional, Hickey, David P., additional, Kuhn, Alexander, additional, Lam, Kevin, additional, Liao, Yun-Ju, additional, Liu, T. Leo, additional, Minteer, Shelley D., additional, Moeller, Kevin, additional, Nguyen, Zachary A., additional, and Shida, Naoki, additional

Published
2023
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9. Interdisciplinary electrosynthesis: general discussion

Author

Ackermann, Lutz, primary, Avanthay, Mickaël, additional, Batanero, Belen, additional, Boucher, Dylan G., additional, Broersen, Pim, additional, Carroll, Emily, additional, Flexer, Victoria, additional, Francke, Robert, additional, Fuchigami, Toshio, additional, Gerulskis, Rokas, additional, Hickey, David P., additional, Hockin, Bee, additional, Kuhn, Alexander, additional, Milner, Matthew J., additional, Minteer, Shelley D., additional, Moeller, Kevin, additional, Nguyen, Zachary A., additional, Nokami, Toshiki, additional, Rasul, Shahid, additional, Shida, Naoki, additional, Sokalu, Eniola, additional, Taniguchi, Kohei, additional, and von Wolff, Niklas, additional

Published
2023
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13. Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness

Author

Barkan, David T., Garland, Keira, Zhang, Lei, Eastman, Richard T., Hesse, Matthew, Knapp, Mark, Ornelas, Elizabeth, Tang, Jenny, Cortopassi, Wilian Augusto, Wang, Yu, King, Frederick, Jia, Weiping, Nguyen, Zachary, Frank, Andreas O., Chan, Ryan, Fang, Eric, Fuller, Daniel, Busby, Scott, Carias, Heidi, Donahue, Kristine, Tandeske, Laura, Diagana, Thierry T., Jarrousse, Nadine, Moser, Heinz, Sarko, Christopher, Dovala, Dustin, Moquin, Stephanie, and Marx, Vanessa M.

Abstract

The COVID-19 pandemic highlights the ongoing risk of zoonotic transmission of coronaviruses to global health. To prepare for future pandemics, it is essential to develop effective antivirals targeting a broad range of coronaviruses. Targeting the essential and clinically validated coronavirus main protease (Mpro), we constructed a structurally diverse Mpropanel by clustering all known coronavirus sequences by Mproactive site sequence similarity. Through screening, we identified a potent covalent inhibitor that engaged the catalytic cysteine of SARS-CoV-2 Mpro and used structure-based medicinal chemistry to develop compounds in the pyrazolopyrimidine sulfone series that exhibit submicromolar activity against multiple Mprohomologues. Additionally, we solved the first X-ray cocrystal structure of Mprofrom the human-infecting OC43 coronavirus, providing insights into potency differences among compound–target pairs. Overall, the chemical compounds described in this study serve as starting points for the development of antivirals with broad-spectrum activity, enhancing our preparedness for emerging human-infecting coronaviruses.

Published
2024
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16. Bioelectrocatalytic Synthesis: Concepts and Applications.

Author

Boucher DG, Carroll E, Nguyen ZA, Jadhav RG, Simoska O, Beaver K, and Minteer SD

Subjects
Biocatalysis, Electricity
Abstract

Bioelectrocatalytic synthesis is the conversion of electrical energy into value-added products using biocatalysts. These methods merge the specificity and selectivity of biocatalysis and energy-related electrocatalysis to address challenges in the sustainable synthesis of pharmaceuticals, commodity chemicals, fuels, feedstocks and fertilizers. However, the specialized experimental setups and domain knowledge for bioelectrocatalysis pose a significant barrier to adoption. This review introduces key concepts of bioelectrosynthetic systems. We provide a tutorial on the methods of biocatalyst utilization, the setup of bioelectrosynthetic cells, and the analytical methods for assessing bioelectrocatalysts. Key applications of bioelectrosynthesis in ammonia production and small-molecule synthesis are outlined for both enzymatic and microbial systems. This review serves as a necessary introduction and resource for the non-specialist interested in bioelectrosynthetic research., (© 2023 Wiley-VCH GmbH.)

Published
2023
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