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4. Supplementary material - Supplemental material for Identification of Anti-Helicobacter pylori Compounds From Usnea undulata

Author

Do, Trung, Nguyen, Trang T.H., Ha, Thai N., Nguyen T.H. Nhu, Nguyen Van Lam, Nguyen T.T. Tram, and Pham, Yen

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, Supplementary material, for Identification of Anti-Helicobacter pylori Compounds From Usnea undulata by Trung Do, Trang T.H. Nguyen, Thai N. Ha, Nguyen T.H. Nhu, Nguyen Van Lam, Nguyen T.T. Tram, and Yen Pham in Natural Product Communications

Published
2019
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7. Identification of Anti-Helicobacter pyloriCompounds From Usnea undulata

Author

Do, Trung, Nguyen, Trang T.H., Ha, Thai N., Nhu, Nguyen T.H., Van Lam, Nguyen, Tram, Nguyen T.T., and Pham, Yen

Abstract

In this study, we evaluated 3 extracts (n-hexane, acetone, and methanol) of Usnea undulataStirton (Usneaaceae) and 5 isolated compounds [methyl orsellinate (1), methyl β-orsellinate (2), 7-hydroxyl-5-methoxy-6-methylphtalide (3), usnic acid (UA) (4), and salazinic acid (5)] for their inhibitory activity against Helicobacter pylori. The results showed that the n-hexane extract exhibited the strongest activity with the largest inhibition zone (d= 14 mm). For the isolated metabolites, besides UA that has been reported as a potent anti-H. pyloriagent, compounds 1and 2showed higher inhibition compared to the reference drugs. Our results demonstrated that U. undulatacould be a promising source of potential anti-H. pylorimetabolites.

Published
2019
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