36 results on '"Nguyen, Tran Nam"'
Search Results
2. Discovery of urinary biosignatures for tuberculosis and nontuberculous mycobacteria classification using metabolomics and machine learning
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Nguyen Ky Anh, Nguyen Ky Phat, Nguyen Quang Thu, Nguyen Tran Nam Tien, Cho Eunsu, Ho-Sook Kim, Duc Ninh Nguyen, Dong Hyun Kim, Nguyen Phuoc Long, and Jee Youn Oh
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Nontuberculous mycobacteria ,Tuberculosis ,Differential diagnosis ,Diagnostic biomarkers ,Metabolomics ,Machine learning ,Medicine ,Science - Abstract
Abstract Nontuberculous mycobacteria (NTM) infection diagnosis remains a challenge due to its overlapping clinical symptoms with tuberculosis (TB), leading to inappropriate treatment. Herein, we employed noninvasive metabolic phenotyping coupled with comprehensive statistical modeling to discover potential biomarkers for the differential diagnosis of NTM infection versus TB. Urine samples from 19 NTM and 35 TB patients were collected, and untargeted metabolomics was performed using rapid liquid chromatography-mass spectrometry. The urine metabolome was analyzed using a combination of univariate and multivariate statistical approaches, incorporating machine learning. Univariate analysis revealed significant alterations in amino acids, especially tryptophan metabolism, in NTM infection compared to TB. Specifically, NTM infection was associated with upregulated levels of methionine but downregulated levels of glutarate, valine, 3-hydroxyanthranilate, and tryptophan. Five machine learning models were used to classify NTM and TB. Notably, the random forest model demonstrated excellent performance [area under the receiver operating characteristic (ROC) curve greater than 0.8] in distinguishing NTM from TB. Six potential biomarkers for NTM infection diagnosis, including methionine, valine, glutarate, 3-hydroxyanthranilate, corticosterone, and indole-3-carboxyaldehyde, were revealed from univariate ROC analysis and machine learning models. Altogether, our study suggested new noninvasive biomarkers and laid a foundation for applying machine learning to NTM differential diagnosis.
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- 2024
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3. Push forward LC-MS-based therapeutic drug monitoring and pharmacometabolomics for anti-tuberculosis precision dosing and comprehensive clinical management
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Nguyen Quang Thu, Nguyen Tran Nam Tien, Nguyen Thi Hai Yen, Thuc-Huy Duong, Nguyen Phuoc Long, and Huy Truong Nguyen
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Tuberculosis ,Therapeutic drug monitoring ,LC-MS ,MIPD ,Pharmacometabolomics ,Precision medicine ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The spread of tuberculosis (TB), especially multidrug-resistant TB and extensively drug-resistant TB, has strongly motivated the research and development of new anti-TB drugs. New strategies to facilitate drug combinations, including pharmacokinetics-guided dose optimization and toxicology studies of first- and second-line anti-TB drugs have also been introduced and recommended. Liquid chromatography-mass spectrometry (LC-MS) has arguably become the gold standard in the analysis of both endo- and exo-genous compounds. This technique has been applied successfully not only for therapeutic drug monitoring (TDM) but also for pharmacometabolomics analysis. TDM improves the effectiveness of treatment, reduces adverse drug reactions, and the likelihood of drug resistance development in TB patients by determining dosage regimens that produce concentrations within the therapeutic target window. Based on TDM, the dose would be optimized individually to achieve favorable outcomes. Pharmacometabolomics is essential in generating and validating hypotheses regarding the metabolism of anti-TB drugs, aiding in the discovery of potential biomarkers for TB diagnostics, treatment monitoring, and outcome evaluation. This article highlighted the current progresses in TDM of anti-TB drugs based on LC-MS bioassay in the last two decades. Besides, we discussed the advantages and disadvantages of this technique in practical use. The pressing need for non-invasive sampling approaches and stability studies of anti-TB drugs was highlighted. Lastly, we provided perspectives on the prospects of combining LC-MS-based TDM and pharmacometabolomics with other advanced strategies (pharmacometrics, drug and vaccine developments, machine learning/artificial intelligence, among others) to encapsulate in an all-inclusive approach to improve treatment outcomes of TB patients.
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- 2024
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4. Regulation of host metabolism and defense strategies to survive neonatal infection
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Wu, Ziyuan, Tien, Nguyen Tran Nam, Bæk, Ole, Zhong, Jingren, Klabunde, Björn, Nguyen, Tinh Thu, Yen, Nguyen Thi Hai, Long, Nguyen Phuoc, and Nguyen, Duc Ninh
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- 2024
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5. Cyclosporine A-induced systemic metabolic perturbations in rats: A comprehensive metabolome analysis
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Yen, Nguyen Thi Hai, Tien, Nguyen Tran Nam, Anh, Nguyen Thi Van, Le, Quoc-Viet, Eunsu, Cho, Kim, Ho-Sook, Moon, Kyoung-Sik, Nguyen, Huy Truong, Kim, Dong Hyun, and Long, Nguyen Phuoc
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- 2024
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6. Age-time-specific transmission of hand-foot-and-mouth disease enterovirus serotypes in Vietnam: A catalytic model with maternal immunity
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Yining Chen, Lam Anh Nguyet, Le Nguyen Thanh Nhan, Phan Tu Qui, Le Nguyen Truc Nhu, Nguyen Thi Thu Hong, Nguyen Thi Han Ny, Nguyen To Anh, Le Kim Thanh, Huynh Thi Phuong, Nguyen Ha Thao Vy, Nguyen Thi Le Thanh, Truong Huu Khanh, Nguyen Thanh Hung, Do Chau Viet, Nguyen Tran Nam, Nguyen Van Vinh Chau, H. Rogier van Doorn, Le Van Tan, and Hannah Clapham
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Hand, foot and mouth disease ,Serological data ,Catalytic model ,Force of infection ,Infectious and parasitic diseases ,RC109-216 - Abstract
Hand, foot and mouth disease (HFMD) is highly prevalent in the Asia Pacific region, particularly in Vietnam. To develop effective interventions and efficient vaccination programs, we inferred the age-time-specific transmission patterns of HFMD serotypes enterovirus A71 (EV-A71), coxsackievirus A6 (CV-A6), coxsackievirus A10 (CV-A10), coxsackievirus A16 (CV-A16) in Ho Chi Minh City, Vietnam from a case data collected during 2013–2018 and a serological survey data collected in 2015 and 2017. We proposed a catalytic model framework with good adaptability to incorporate maternal immunity using various mathematical functions. Our results indicate the high-level transmission of CV-A6 and CV-A10 which is not obvious in the case data, due to the variation of disease severity across serotypes. Our results provide statistical evidence supporting the strong association between severe illness and CV-A6 and EV-A71 infections. The HFMD dynamic pattern presents a cyclical pattern with large outbreaks followed by a decline in subsequent years. Additionally, we identify the age group with highest risk of infection as 1-2 years and emphasise the risk of future outbreaks as over 50% of children aged 6-7 years were estimated to be susceptible to CV-A16 and EV-A71. Our study highlights the importance of multivalent vaccines and active surveillance for different serotypes, supports early vaccination prior to 1 year old, and points out the potential utility for vaccinating children older than 5 years old in Vietnam.
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- 2024
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7. Metabolic phenotyping and global functional analysis facilitate metabolic signature discovery for tuberculosis treatment monitoring
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Anh, Nguyen Ky, Yen, Nguyen Thi Hai, Tien, Nguyen Tran Nam, Phat, Nguyen Ky, Park, Young Jin, Kim, Ho-Sook, Vu, Dinh Hoa, Oh, Jee Youn, Kim, Dong Hyun, and Long, Nguyen Phuoc
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- 2024
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8. Push forward LC-MS-based therapeutic drug monitoring and pharmacometabolomics for anti-tuberculosis precision dosing and comprehensive clinical management
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Thu, Nguyen Quang, Tien, Nguyen Tran Nam, Yen, Nguyen Thi Hai, Duong, Thuc-Huy, Long, Nguyen Phuoc, and Nguyen, Huy Truong
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- 2024
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9. Alterations of lipid-related genes during anti-tuberculosis treatment: insights into host immune responses and potential transcriptional biomarkers
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Nguyen Ky Phat, Nguyen Tran Nam Tien, Nguyen Ky Anh, Nguyen Thi Hai Yen, Yoon Ah Lee, Hoang Kim Tu Trinh, Kieu-Minh Le, Sangzin Ahn, Yong-Soon Cho, Seongoh Park, Dong Hyun Kim, Nguyen Phuoc Long, and Jae-Gook Shin
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tuberculosis ,lipid-related gene ,transcriptomic biomarker ,treatment monitoring ,differential diagnosis ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundThe optimal diagnosis and treatment of tuberculosis (TB) are challenging due to underdiagnosis and inadequate treatment monitoring. Lipid-related genes are crucial components of the host immune response in TB. However, their dynamic expression and potential usefulness for monitoring response to anti-TB treatment are unclear. MethodologyIn the present study, we used a targeted, knowledge-based approach to investigate the expression of lipid-related genes during anti-TB treatment and their potential use as biomarkers of treatment response. Results and discussionThe expression levels of 10 genes (ARPC5, ACSL4, PLD4, LIPA, CHMP2B, RAB5A, GABARAPL2, PLA2G4A, MBOAT2, and MBOAT1) were significantly altered during standard anti-TB treatment. We evaluated the potential usefulness of this 10-lipid-gene signature for TB diagnosis and treatment monitoring in various clinical scenarios across multiple populations. We also compared this signature with other transcriptomic signatures. The 10-lipid-gene signature could distinguish patients with TB from those with latent tuberculosis infection and non-TB controls (area under the receiver operating characteristic curve > 0.7 for most cases); it could also be useful for monitoring response to anti-TB treatment. Although the performance of the new signature was not better than that of previous signatures (i.e., RISK6, Sambarey10, Long10), our results suggest the usefulness of metabolism-centric biomarkersConclusionsLipid-related genes play significant roles in TB pathophysiology and host immune responses. Furthermore, transcriptomic signatures related to the immune response and lipid-related gene may be useful for TB diagnosis and treatment monitoring.
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- 2023
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10. Burden of Postinfectious Symptoms after Acute Dengue, Vietnam
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Dong Thi Hoai Tam, Hannah Clapham, Elisabeth Giger, Nguyen Tan Thanh Kieu, Nguyen Tran Nam, Dinh Thi Tri Hong, Banh Thi Nuoi, Nguyen Thi Hong Cam, Nguyen Than Ha Quyen, Hugo C. Turner, Thomas Jaenisch, Cameron P. Simmons, Phung Khanh Lam, and Bridget Wills
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dengue ,viruses ,vector-borne infections ,burden ,Vietnam ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
We assessed predominantly pediatric patients in Vietnam with dengue and other febrile illness 3 months after acute illness. Among dengue patients, 47% reported >1 postacute symptom. Most resolved by 3 months, but alopecia and vision problems often persisted. Our findings provide additional evidence on postacute dengue burden and confirm children are affected.
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- 2023
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11. Early diagnostic indicators of dengue versus other febrile illnesses in Asia and Latin America (IDAMS study): a multicentre, prospective, observational study
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Hasan, Zabir, Wanderley Lopes Gomes, Kilma, Soares Mesquita, Lyvia Patricia, Braga, Cynthia, Castanha, Priscila M.S., Cordeiro, Marli T., Damasceno, Luana, Chuop, Bophal, Ouk, Sonyrath, Sin, Reaksmey, Sun, Sopheary, Alvarez Vera, Mayling, Barahona, Guillermo, Cruz, Bladimir, Beck, Dorothea, Gaczkowski, Roger, Junghanss, Thomas, Morales, Ivonne, Wirths, Marius, Natkunam, Santha Kumari, Ho, Bee Kiau, AbuBakar, Sazaly, Abd-Jamil, Juraina, Syed Omar, Sharifah Faridah, Lizarazo, Erley F., Vincenti-González, María F., Tovar, Robert, Cao Thi, Tam, Dinh Thi Tri, Hong, Huynh Le Anh, Huy, Huynh Thi Le, Duyen, Lai Thi Cong, Thanh, Nguyen Thi Hong, Van, Nguyen Thi My, Linh, Tran Thi Nhu, Thuy, Truong Thi Thu, Thuy, Banh Thi, Nuoi, Huynh Lam Thuy, Trinh, Nguyen Thi Thu, Hiep, Tran Thi Kim, Van, Vo Thanh, Luan, Dang Thi, Bich, Dinh Thi Thu, Huong, Dinh Van, Huy, Nguyen Nguyen, Huyen, Vu Thi Thu, Huong, Rosenberger, Kerstin D, Phung Khanh, Lam, Tobian, Frank, Chanpheaktra, Ngoun, Kumar, Varun, Lum, Lucy Chai See, Sathar, Jameela, Pleités Sandoval, Ernesto, Marón, Gabriela M, Laksono, Ida Safitri, Mahendradhata, Yodi, Sarker, Malabika, Rahman, Ridwanur, Caprara, Andrea, Souza Benevides, Bruno, Marques, Ernesto T A, Magalhaes, Tereza, Brasil, Patrícia, Amaral Calvet, Guilherme, Tami, Adriana, Bethencourt, Sarah E, Dong Thi Hoai, Tam, Nguyen Tan Thanh, Kieu, Tran Van, Ngoc, Nguyen Tran, Nam, Do Chau, Viet, Yacoub, Sophie, Nguyen Van, Kinh, Guzmán, María G, Martinez, Pedro A, Nguyen Than Ha, Quyen, Simmons, Cameron P, Wills, Bridget A, Geskus, Ronald B, and Jaenisch, Thomas
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- 2023
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12. Pretomanid resistance: an update on emergence, mechanisms and relevance for clinical practice
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Nguyen, Thi Van Anh, Nguyen, Quang Huy, Nguyen, Tran Nam Tien, Anthony, Richard M., Vu, Dinh Hoa, and Alffenaar, Jan-Willem C.
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- 2023
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13. Cyclosporine A-Induced Systemic Metabolic Perturbations in Rats: A Comprehensive Metabolome Analysis
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Thi Hai Yen, Nguyen, primary, Tien, Nguyen Tran Nam, additional, Thi Van Anh, Nguyen, additional, Le, Quoc-Viet, additional, Eunsu, Cho, additional, Kim, Ho-Sook, additional, Moon, Kyoung-Sik, additional, Nguyen, Huy Truong, additional, Kim, Dong Hyun, additional, and Long, Nguyen Phuoc, additional
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- 2024
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14. Regulation of host metabolism and defense strategies to survive neonatal infection
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Wu, Ziyuan, primary, Tien, Nguyen Tran Nam, additional, Bæk, Ole, additional, Zhong, Jingren, additional, Klabunde, Björn, additional, Nguyen, Tinh Thu, additional, Yen, Nguyen Thi Hai, additional, Long, Nguyen Phuoc, additional, and Nguyen, Duc Ninh, additional
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- 2024
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15. Time-course cross-species transcriptomics reveals conserved hepatotoxicity pathways induced by repeated administration of cyclosporine A.
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Tien, Nguyen Tran Nam, Anh, Trinh Tam, Yen, Nguyen Thi Hai, Anh, Nguyen Ky, Nguyen, Huy Truong, Kim, Ho-Sook, Oh, Jung-Hwa, Kim, Dong-Hyun, and Long, Nguyen Phuoc
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Cyclosporine A (CsA) has shown efficacy against immunity-related diseases despite its toxicity in various organs, including the liver, emphasizing the need to elucidate its underlying hepatotoxicity mechanism. This study aimed to capture the alterations in genome-wide expression over time and the subsequent perturbations of corresponding pathways across species. Six data from humans, mice, and rats, including animal liver tissue, human liver microtissues, and two liver cell lines exposed to CsA toxic dose, were used. The microtissue exposed to CsA for 10 d was analyzed to obtain dynamically differentially expressed genes (DEGs). Single-time points data at 1, 3, 5, 7, and 28 d of different species were used to provide additional evidence. Using liver microtissue-based longitudinal design, DEGs that were consistently up- or down-regulated over time were captured, and the well-known mechanism involved in CsA toxicity was elucidated. Thirty DEGs that consistently changed in longitudinal data were also altered in 28-d rat in-house data with concordant expression. Some genes (e.g. TUBB2A, PLIN2, APOB) showed good concordance with identified DEGs in 1-d and 7-d mouse data. Pathway analysis revealed up-regulations of protein processing, asparagine N-linked glycosylation, and cargo concentration in the endoplasmic reticulum. Furthermore, the down-regulations of pathways related to biological oxidations and metabolite and lipid metabolism were elucidated. These pathways were also enriched in single-time-point data and conserved across species, implying their biological significance and generalizability. Overall, the human organoids-based longitudinal design coupled with cross-species validation provides temporal molecular change tracking, aiding mechanistic elucidation and biologically relevant biomarker discovery. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Newly detected paediatric melioidosis cases in a single referral children's hospital in Ho Chi Minh City indicate the probable underrecognition of melioidosis in South Vietnam
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Pham, Thai Son, primary, König, Elisabeth, additional, Bui, The Trung, additional, Vu, Thi Ngoc Anh, additional, Nguyen, Tran Nam, additional, Do, Chau Viet, additional, Lichtenegger, Sabine, additional, Bui, Nguyen Hai Linh, additional, Trinh, Huu Tung, additional, Steinmetz, Ivo, additional, and Trinh, Thanh Trung, additional
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- 2023
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17. Clinical and aetiological study of hand, foot and mouth disease in southern Vietnam, 2013–2015: Inpatients and outpatients
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Hoang, Minh Tu Van, Nguyen, To Anh, Tran, Tan Thanh, Vu, Thi Ty Hang, Le, Nguyen Truc Nhu, Nguyen, Thi Han Ny, Le, Thanh Hoang Nhat, Nguyen, Thi Thu Hong, Nguyen, Thanh Hung, Le, Nguyen Thanh Nhan, Truong, Huu Khanh, Du, Tuan Quy, Ha, Manh Tuan, Ho, Lu Viet, Do, Chau Viet, Nguyen, Tran Nam, Nguyen, Thi My Thanh, Sabanathan, Saraswathy, Phan, Tu Qui, Nguyen Van, Vinh Chau, Thwaites, Guy E., Wills, Bridget, Thwaites, C. Louise, Le, Van Tan, and van Doorn, H. Rogier
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- 2019
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18. Newly detected paediatric melioidosis cases in a single referral children's hospital in Ho Chi Minh City indicate the probable underrecognition of melioidosis in South Vietnam.
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Pham, Thai Son, König, Elisabeth, Bui, The Trung, Vu, Thi Ngoc Anh, Nguyen, Tran Nam, Do, Chau Viet, Lichtenegger, Sabine, Bui, Nguyen Hai Linh, Trinh, Huu Tung, Steinmetz, Ivo, and Trinh, Thanh Trung
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MELIOIDOSIS ,CHILDREN'S hospitals ,CITIES & towns ,SOIL microbiology ,BURKHOLDERIA pseudomallei - Abstract
Background The epidemiology of melioidosis in Vietnam, a disease caused by the soil bacterium Burkholderia pseudomallei , remains unclear. This study aimed to detect paediatric melioidosis in South Vietnam and describe clinical features and the geographic distribution. Methods We introduced a simple laboratory algorithm for detecting B. pseudomallei from clinical samples at Children's Hospital 2 in Ho Chi Minh City in July 2015. A retrospective observational study of children <16 y of age with culture-confirmed melioidosis between July 2015 and August 2019 was undertaken. Results Thirty-five paediatric cases of melioidosis were detected, with cases originating from 13 of 32 provinces and cities in South Vietnam. The number of paediatric melioidosis cases detected from a certain region correlated with the overall number of inpatients originating from the respective geographic area. Suppurative parotitis (n=15 [42.8%]) was the most common clinical presentation, followed by lung infection (n=10 [28.6%]) and septicaemia (n=7 [20%]). Fourteen (40%) children had disseminated disease, including all cases of lung infection, four cases with central nervous system symptoms and four (11.4%) deaths. Conclusions The patients' origin indicates a wide distribution of melioidosis in South Vietnam. It seems probable that cases not only in children, but also in adults, remain grossly undiagnosed. Further awareness raising and laboratory capacity strengthening are needed in this part of the country. [ABSTRACT FROM AUTHOR]
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- 2024
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19. Alterations of lipid-related genes during anti-tuberculosis treatment: insights into host immune responses and potential transcriptional biomarkers
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Phat, Nguyen Ky, primary, Tien, Nguyen Tran Nam, additional, Anh, Nguyen Ky, additional, Yen, Nguyen Thi Hai, additional, Lee, Yoon Ah, additional, Trinh, Hoang Kim Tu, additional, Le, Kieu-Minh, additional, Ahn, Sangzin, additional, Cho, Yong-Soon, additional, Park, Seongoh, additional, Kim, Dong Hyun, additional, Long, Nguyen Phuoc, additional, and Shin, Jae-Gook, additional
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- 2023
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20. Emerging Coxsackievirus A6 Causing Hand, Foot and Mouth Disease, Vietnam
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Nguyen To Anh, Le Nguyen Truc Nhu, Hoang Minh Tu Van, Nguyen Thi Thu Hong, Tran Tan Thanh, Vu Thi Ty Hang, Nguyen Thi Han Ny, Lam Anh Nguyet, Tran Thi Lan Phuong, Le Nguyen Thanh Nhan, Nguyen Thanh Hung, Truong Huu Khanh, Ha Manh Tuan, Ho Lu Viet, Nguyen Tran Nam, Do Chau Viet, Phan Tu Qui, Bridget Wills, Sarawathy Sabanathan, Nguyen Van Vinh Chau, Louise Thwaites, H. Rogier van Doorn, Guy Thwaites, Maia A. Rabaa, and Le Van Tan
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Hand foot and mouth disease ,Vietnam ,deep sequencing ,phylogeny ,coxsackievirus A6 ,Asia ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Hand, foot and mouth disease (HFMD) is a major public health issue in Asia and has global pandemic potential. Coxsackievirus A6 (CV-A6) was detected in 514/2,230 (23%) of HFMD patients admitted to 3 major hospitals in southern Vietnam during 2011–2015. Of these patients, 93 (18%) had severe HFMD. Phylogenetic analysis of 98 genome sequences revealed they belonged to cluster A and had been circulating in Vietnam for 2 years before emergence. CV-A6 movement among localities within Vietnam occurred frequently, whereas viral movement across international borders appeared rare. Skyline plots identified fluctuations in the relative genetic diversity of CV-A6 corresponding to large CV-A6–associated HFMD outbreaks worldwide. These data show that CV-A6 is an emerging pathogen and emphasize the necessity of active surveillance and understanding the mechanisms that shape the pathogen evolution and emergence, which is essential for development and implementation of intervention strategies.
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- 2018
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21. Newly detected pediatric melioidosis cases in a single referral children’s hospital in Ho Chi Minh City indicate the probable under-recognition of melioidosis in South Vietnam
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Pham, Thai Son, primary, König, Elisabeth, additional, Bui, The Trung, additional, Vu, Thi Ngoc Anh, additional, Nguyen, Tran Nam, additional, Do, Chau Viet, additional, Lichtenegger, Sabine, additional, Bui, Nguyen Hai Linh, additional, Trinh, Huu Tung, additional, Steinmetz, Ivo, additional, and Trinh, Thanh Trung, additional
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- 2023
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22. Early diagnostic indicators of dengue versus other febrile illnesses in Asia and Latin America (IDAMS study): a multicentre, prospective, observational study
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Rosenberger, Kerstin D, primary, Phung Khanh, Lam, additional, Tobian, Frank, additional, Chanpheaktra, Ngoun, additional, Kumar, Varun, additional, Lum, Lucy Chai See, additional, Sathar, Jameela, additional, Pleités Sandoval, Ernesto, additional, Marón, Gabriela M, additional, Laksono, Ida Safitri, additional, Mahendradhata, Yodi, additional, Sarker, Malabika, additional, Rahman, Ridwanur, additional, Caprara, Andrea, additional, Souza Benevides, Bruno, additional, Marques, Ernesto T A, additional, Magalhaes, Tereza, additional, Brasil, Patrícia, additional, Amaral Calvet, Guilherme, additional, Tami, Adriana, additional, Bethencourt, Sarah E, additional, Dong Thi Hoai, Tam, additional, Nguyen Tan Thanh, Kieu, additional, Tran Van, Ngoc, additional, Nguyen Tran, Nam, additional, Do Chau, Viet, additional, Yacoub, Sophie, additional, Nguyen Van, Kinh, additional, Guzmán, María G, additional, Martinez, Pedro A, additional, Nguyen Than Ha, Quyen, additional, Simmons, Cameron P, additional, Wills, Bridget A, additional, Geskus, Ronald B, additional, Jaenisch, Thomas, additional, Hasan, Zabir, additional, Wanderley Lopes Gomes, Kilma, additional, Soares Mesquita, Lyvia Patricia, additional, Braga, Cynthia, additional, Castanha, Priscila M.S., additional, Cordeiro, Marli T., additional, Damasceno, Luana, additional, Chuop, Bophal, additional, Ouk, Sonyrath, additional, Sin, Reaksmey, additional, Sun, Sopheary, additional, Alvarez Vera, Mayling, additional, Barahona, Guillermo, additional, Cruz, Bladimir, additional, Beck, Dorothea, additional, Gaczkowski, Roger, additional, Junghanss, Thomas, additional, Morales, Ivonne, additional, Wirths, Marius, additional, Natkunam, Santha Kumari, additional, Ho, Bee Kiau, additional, AbuBakar, Sazaly, additional, Abd-Jamil, Juraina, additional, Syed Omar, Sharifah Faridah, additional, Lizarazo, Erley F., additional, Vincenti-González, María F., additional, Tovar, Robert, additional, Cao Thi, Tam, additional, Dinh Thi Tri, Hong, additional, Huynh Le Anh, Huy, additional, Huynh Thi Le, Duyen, additional, Lai Thi Cong, Thanh, additional, Nguyen Thi Hong, Van, additional, Nguyen Thi My, Linh, additional, Tran Thi Nhu, Thuy, additional, Truong Thi Thu, Thuy, additional, Banh Thi, Nuoi, additional, Huynh Lam Thuy, Trinh, additional, Nguyen Thi Thu, Hiep, additional, Tran Thi Kim, Van, additional, Vo Thanh, Luan, additional, Dang Thi, Bich, additional, Dinh Thi Thu, Huong, additional, Dinh Van, Huy, additional, Nguyen Nguyen, Huyen, additional, and Vu Thi Thu, Huong, additional
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- 2023
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23. Structure–activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo
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Caraballo, Rémi, Larsson, Mikael, Nilsson, Stefan K., Ericsson, Madelene, Qian, Weixing, Nguyen Tran, Nam Phuong, Kindahl, Tomas, Svensson, Richard, Saar, Valeria, Artursson, Per, Olivecrona, Gunilla, Enquist, Per-Anders, and Elofsson, Mikael
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- 2015
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24. Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis.
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Mohamed Gomaa Kamel, Nguyen Tran Nam, Nguyen Huu Bao Han, Abd-Elaziz El-Shabouny, Abd-ElRahman Mohamed Makram, Fatma Abd-Elshahed Abd-Elhay, Tran Ngoc Dang, Nguyen Le Trung Hieu, Vu Thi Que Huong, Trinh Huu Tung, Kenji Hirayama, and Nguyen Tien Huy
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Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
Dengue is one of the most common infectious diseases. The aim of this study was to systematically review acute disseminated encephalomyelitis (ADEM) and to represent a new case.We searched for articles in nine databases for case reports, series or previous reviews reporting ADEM cases in human. We used Fisher's exact and Mann-Whitney U tests. Classification trees were used to find the predictors of the disease outcomes. We combined findings using fixed- and random-effects models. A 13-year-old girl was admitted to the hospital due to fever. She has a urinary retention. The neurological examinations revealed that she became lethargic and quadriplegic. She had upper limbs weakness and lower limbs complete paraplegia. Her status gradually improved after the treatment. She was nearly intact with the proximal part of her legs had a mild weakness in discharge. The prevalence of ADEM among dengue patients was 0.4% [95% confidence intervals (95% CI) 0.1-2.5%], all neurological disorders among dengue was 2.6% [95% CI 1.8-3.8%], and ADEM among neurological disorders was 6.8% [95% CI 3.4-13%]. The most frequent manifestation of ADEM was altered sensorium/consciousness (58%), seizures and urination problems (35%), vision problems (31%), slurred speech (23%), walk problems (15%) then ataxia (12%). There was a significant difference between cases having complete recovery or bad outcomes in the onset day of neurological manifestations being earlier and in temperature being higher in cases having bad outcomes (p-value < 0.05). This was confirmed by classification trees which included these two variables.The prevalence of ADEM among dengue and other dengue-related neurological disorders is not too rare. The high fever of ADEM cases at admission and earlier onset day of neurological manifestations are associated with the bad outcomes.
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- 2017
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25. Workshop on Use of Intravenous Immunoglobulin in Hand, Foot and Mouth Disease in Southeast Asia
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Sokkosal Chea, Yi-bing Cheng, Kulkanya Chokephaibulkit, Tawee Chotpitayasunondh, H. Rogier van Doorn, Zen Hafy, Surinda Kawichai, Ching-Chuan Liu, Nguyen Tran Nam, Mong How Ooi, Marcel Wolbers, and Mei Zeng
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enterovirus ,enterovirus 71 ,hand foot and mouth disease ,intravenous immunoglobulin ,Southeast Asia ,workshop ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
The South East Asia Infectious Disease Clinical Research Network convened subject matter experts at a workshop to make consensus recommendations for study design of a clinical trial for use of intravenous immunoglobulin (IVIg) in severe hand, foot and mouth disease (HFMD). HFMD is a highly contagious emerging infection among children in the region, a small proportion of whom develop neurologic and cardiopulmonary complications with high case-fatality rates. The use of IVIg for treatment of severe disease is widespread and a part of local, national, and international guidelines, but no clinical evidence warrants the use of this drug, which is expensive and has potentially serious side effects. During a 2-day workshop in March 2014, a group of HFMD experts reviewed the current evidence related to use of IVIg in HFMD and discussed potential study design, feasibility, inclusion and exclusion criteria, sample size, primary and secondary endpoints, and subsidiary studies for a randomized, placebo-controlled trial.
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- 2015
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26. Making the IELTS more communicative, motivative and meaningful to EFL learners
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Nguyen Tran Nam Phuong
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IELTS teaching, communicative, meaningful, student-centred - Abstract
Internationalisation is of growing significance worldwide, with obvious changes and broaderdevelopments in higher education around the world. In order to fulfill the requirements of institutionsand universities worldwide, IELTS exam has become essential for EFL learners who want to studyabroad in an English speaking nation. Offering access to higher education in developed parts of the world, IELTS preparation courses could be strongly influenced by the principles of communicativelanguage teaching (Green, 2007). As an instructor, the responsibility is not only raising theawareness of exam strategies but also to enhance the needed skills which may bring the learnerssuccess in later life. The purpose of “exam preparation” might be considered too narrow andcontrolled in comparison with modern TESOL principles which aim at maximizing authenticcommunicative contexts and student-centredactivities. Rather than just an introduction of the examformat and “teaching the test”, modern world encourages teachers take into account theachievement of more stimulating ways of ensuring a healthy balance between social and academiclanguage acquisition. Hopefully, this speech could bring a reflection on to what extent IELTSclasses could become more communicative, motivative and meaningful to learners, and thenpropose several classroom activities, focus on how to teach the test in a communicative fashion.  
- Published
- 2019
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27. Maneuverable Autonomy of a Six-legged Walking Robot: Design and Implementation using Deep Neural Networks and Hexapod Locomotion
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Huynh, Hiep Xuan, primary, Duong-Trung, Nghia, additional, Nguyen, Tran Nam Quoc, additional, Le, Bao Hoai, additional, and Le, Tam Hung, additional
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- 2021
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28. A46 Hand, foot, and mouth disease in Vietnam
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Nguyen To Anh, Saraswathy Sabanathan, Le Nguyen Truc Nhu, H. Rogier van Doorn, Phan Tu Qui, Nguyen Tran Nam, Nguyen Thi Han Ny, Truong Huu Khanh, Hoang Minh Tu Van, C. Louise Thwaites, Ha Manh Tuan, Le Nguyen Thanh Nhan, Le Van Tan, Du Tuan Quy, Tran Tan Thanh, Bridget Wills, Nguyen Thi My Thanh, Guy E. Thwaites, Ho Lu Viet, Nguyen Thi Thu Hong, Nguyen Van Vinh Chau, Nguyen Thanh Hung, Vu Thi Ty Hang, and Do Chau Viet
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medicine.medical_specialty ,Physical medicine and rehabilitation ,business.industry ,Virology ,medicine ,Abstract Overview ,medicine.disease ,business ,Microbiology ,Hand-foot-and-mouth disease - Abstract
Hand, Foot, and Mouth Disease (HFMD) is a major public health issue in the Asia-Pacific region. Our research program aims to address unanswered questions about clinical, epidemiology, pathogen evolution, cost of illness, and host-genetic makers associated with severe HFMD in Vietnam. A multi-hospital-based observational study has been conducted at three referral hospitals in Ho Chi Minh City, Vietnam since 2013. Demographic, clinical data, and cost of illness were collected alongside clinical specimens. Multiplex PCR and next-generation sequencing were employed to identify enterovirus serotypes and to study pathogen evolution, respectively. A genome-wide association-based approach was used to explore genetic markers of disease severity. From 2013 to 2017, 2,191 HFMD patients were enrolled. More than twenty enterovirus serotypes were detected in 84.3 per cent of patients. EV-A71 was the major cause, accounting for 22 per cent of total number of cases, followed by CV-A6 (21%), CV-A16 (13%), and CV-A10 (8%). Interestingly, these four common enteroviruses replaced each other during the study period. EV-A71 and CV-A6 were the two most predominant viruses detected in 2013 and 2014. However, CV-A6 was replaced by CV-A16 and CV-A10 in 2015 and 2016, respectively. A total of 396 whole-genome sequences (EV-A71 (n = 200), CV-A6 (n = 98), CV-A10 (n = 66), and CV-A16 (n = 32)) were obtained. Phylogenetic analysis showed that EV-A71 subgenogroup B5 has replaced C4 in 2012, and, since then, B5 has continued to circulate predominantly, while C4 has been sporadically detected. All Vietnamese CV-A6 isolates belonged to genogroup A, which has caused large outbreaks of HFMD worldwide. Costs of illness varied between disease severities, ranging from $USD 244 [95% confidence interval (95% CI): 230–258] per patient for grade 2A (mild) to $USD 1984 (95% CI: 1,752–2,227) for grade 3 (severe). The genome-wide association study identified two genetic markers potentially associated with severe HFMD. The results highlight that active surveillance and understanding pathogen evolution are essential to inform public health in prioritizing the development of intervention strategies. Efforts to unravel the evolutionary process of Vietnamese CV-A10 and CV-A16 in relation to global strains are ongoing. An independent cohort is needed to replicate the preliminary findings of the genome-wide association study.
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- 2019
29. Dengue hemophagocytic syndrome: A systematic review and meta‐analysis on epidemiology, clinical signs, outcomes, and risk factors
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Nguyen Hoang Tuan, Le Huu Nhat Minh, Nguyen Tran Nam, Maryan Samsom, Luu Lam Thang Tai, Kenji Hirayama, Le Thai Loc, Hoang Thi Nam Giang, Asmaa Eltobgy, Yaser Reda, Lam Tuyet Trinh, Nguyen Tien Huy, Adnan Khan, and Keita Banno
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medicine.medical_specialty ,Pediatrics ,Anemia ,030231 tropical medicine ,Pacific Islands ,Lymphohistiocytosis, Hemophagocytic ,Dengue fever ,Dengue ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Virology ,Epidemiology ,Case fatality rate ,medicine ,Humans ,030212 general & internal medicine ,Asia, Southeastern ,Hemophagocytic lymphohistiocytosis ,business.industry ,Absolute risk reduction ,medicine.disease ,Survival Analysis ,Treatment Outcome ,Infectious Diseases ,Macrophage activation syndrome ,Meta-analysis ,Americas ,business - Abstract
We systematically searched and meta-analyzed the epidemiological characteristics, frequency of clinical signs, and outcomes of dengue-associated hemophagocytic lymphohistiocytosis. Ten electronic databases were searched systematically plus manual search of reference lists to identify relevant articles published until May 2017. The highest number of reported cases were from South-East Asia region (62 cases), followed by Western Pacific region (20 cases), and America (31 cases). The term "dengue hemorrhagic fever" predominated in studies that used the World Health Organization 1997 definition (59.7%), whereas "severe dengue" predominated in studies using the World Health Organization 2009 definition (76.8%). Among 122 cases, fever, splenomegaly, hepatomegaly, anemia, thrombocytopenia, and serum ferritin ≥500 μg/L were likely to report by articles representing by large sample size. The pooled proportion of these findings were as follows: fever 97.2%, hepatomegaly 70.2%, splenomegaly 78.4%, thrombocytopenia 90.1%, anemia 76.0%, and serum ferritin ≥500 μg/L 97.1%. This study highlighted a high case fatality rate (14.6%) and co-infection among dengue hemophagocytic lymphohistiocytosis patients. We suggest that long fever duration, persistent thrombocytopenia, elevated serum ferritin, and lactate dehydrogenase levels could be good diagnostic indicators for dengue-associated hemophagocytic syndrome. Bone marrow aspiration could be used as one criterion for diagnosis but is not obligatory. Further research is needed to examine the possible risk difference for development of hemophagocytic syndrome and to explore potential relationships between specific dengue classifications and dengue-associated hemophagocytic syndrome.
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- 2018
30. A57 Clinical features and virology of hand, foot, and mouth disease in southern Vietnam from July 2013 to July 2015
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Ho Lu Viet, Nguyen Thi Han Ny, Phan Tu Qui, Nguyen Thi Thu Hong, Chau Viet, H. Rogier van Doorn, Le Thanh Hoang Nhat, Nguyen Truc Trang, Nguyen Van Vinh Chau, C. Louise Thwaites, Vu Thi Ty Hang, Hoang Minh Tu Van, Ha Manh Tuan, Tran Tan Thanh, Nguyen Thi My Thanh, Guy E. Thwaites, Nguyen Thanh Hung, Truong Huu Khanh, Le Nguyen Thanh Nhan, Nguyen Tran Nam, Saraswathy Sabanathan, Nguyen To Anh, Le Nguyen Truc Nhu, and Le Van Tan
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medicine.medical_specialty ,business.industry ,Virology ,Abstract Overview ,medicine ,22nd International BioInformatics Workshop on Virus Evolution and Molecular Epidemiology ,medicine.disease ,business ,Microbiology ,Dermatology ,Hand-foot-and-mouth disease - Published
- 2018
31. Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis
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Nguyen Huu Bao Han, Trinh Huu Tung, Abd-Elaziz El-Shabouny, Nguyen Le Trung Hieu, Tran Ngoc Dang, Vu Thi Que Huong, Abdelrahman M Makram, Nguyen Tran Nam, Kenji Hirayama, Mohamed Gomaa Kamel, Fatma Abd-Elshahed Abd-Elhay, and Nguyen Tien Huy
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Male ,myalgia ,Viral Diseases ,Pediatrics ,Neurology ,Physiology ,Fevers ,Urine ,Pathology and Laboratory Medicine ,Dengue Fever ,Diagnostic Radiology ,Dengue fever ,Dengue ,0302 clinical medicine ,Medicine and Health Sciences ,Prevalence ,030212 general & internal medicine ,Young adult ,Child ,Headaches ,Radiology and Imaging ,lcsh:Public aspects of medicine ,Encephalomyelitis, Acute Disseminated ,Middle Aged ,Magnetic Resonance Imaging ,Body Fluids ,Infectious Diseases ,Child, Preschool ,Acute disseminated encephalomyelitis ,Vomiting ,Female ,Anatomy ,medicine.symptom ,Research Article ,Neglected Tropical Diseases ,Adult ,medicine.medical_specialty ,Ataxia ,lcsh:Arctic medicine. Tropical medicine ,Adolescent ,Imaging Techniques ,lcsh:RC955-962 ,Pain ,Research and Analysis Methods ,Young Adult ,03 medical and health sciences ,Signs and Symptoms ,Diagnostic Medicine ,medicine ,Humans ,Aged ,Solute Carrier Proteins ,business.industry ,Infant, Newborn ,Public Health, Environmental and Occupational Health ,Biology and Life Sciences ,Infant ,Membrane Proteins ,lcsh:RA1-1270 ,Myalgia ,Tropical Diseases ,medicine.disease ,Surgery ,Physiological Processes ,Carrier Proteins ,business ,030217 neurology & neurosurgery - Abstract
Background Dengue is one of the most common infectious diseases. The aim of this study was to systematically review acute disseminated encephalomyelitis (ADEM) and to represent a new case. Methodology/Principal findings We searched for articles in nine databases for case reports, series or previous reviews reporting ADEM cases in human. We used Fisher’s exact and Mann-Whitney U tests. Classification trees were used to find the predictors of the disease outcomes. We combined findings using fixed- and random-effects models. A 13-year-old girl was admitted to the hospital due to fever. She has a urinary retention. The neurological examinations revealed that she became lethargic and quadriplegic. She had upper limbs weakness and lower limbs complete paraplegia. Her status gradually improved after the treatment. She was nearly intact with the proximal part of her legs had a mild weakness in discharge. The prevalence of ADEM among dengue patients was 0.4% [95% confidence intervals (95% CI) 0.1–2.5%], all neurological disorders among dengue was 2.6% [95% CI 1.8–3.8%], and ADEM among neurological disorders was 6.8% [95% CI 3.4–13%]. The most frequent manifestation of ADEM was altered sensorium/consciousness (58%), seizures and urination problems (35%), vision problems (31%), slurred speech (23%), walk problems (15%) then ataxia (12%). There was a significant difference between cases having complete recovery or bad outcomes in the onset day of neurological manifestations being earlier and in temperature being higher in cases having bad outcomes (p-value < 0.05). This was confirmed by classification trees which included these two variables. Conclusions/Significance The prevalence of ADEM among dengue and other dengue-related neurological disorders is not too rare. The high fever of ADEM cases at admission and earlier onset day of neurological manifestations are associated with the bad outcomes., Author summary We presented a 13-year-old girl of ADEM following dengue infection. She was totally alert and had a low grade of fever with no focal neurologic deficits, on admission. We revealed that the prevalence of either ADEM or all neurological disorders among dengue patients was not too rare. Moreover, we found that the most common manifestation of ADEM was altered sensorium/consciousness followed by seizures and urination problems then vision problems. These manifestations should be considered in the diagnosis and management of dengue-infected patients. Also, this requires shedding the light on the total global cases of ADEM from the annual incidence of dengue. The onset of ADEM can be early or late after dengue infection. Hence, clinicians should pay attention that it can be early or late that patients can forget about their fevers. Moreover, the onset day of neurological manifestations and patients’ temperature were significantly associated with the disease outcome.
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- 2017
32. Dengue hemophagocytic syndrome: a systematic review and meta-analysis on epidemiology, clinical signs, outcomes and risk factors
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Giang, Hoang Nam, Banno, Keita, Minh, Le Huu Nhat, Tai, Luu Lam Thang, Trinh, Lam Tuyet, Loc, Le Thai, Samson, Maryam, Adnal Khan, Nguyen Tran Nam, Reda, Yaser, Hirayama, Kenji, and Nguyen, Huy
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- 2017
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33. Workshop on Use of Intravenous Immunoglobulin in Hand, Foot and Mouth Disease in Southeast Asia
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Yibing Cheng, Tawee Chotpitayasunondh, Mong How Ooi, Marcel Wolbers, H. Rogier van Doorn, Zen Hafy, Sokkosal Chea, Mei Zeng, Surinda Kawichai, Nguyen Tran Nam, Ching Chuan Liu, and Kulkanya Chokephaibulkit
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IVIg ,Microbiology (medical) ,medicine.medical_specialty ,workshop ,Epidemiology ,MEDLINE ,hand foot and mouth disease ,lcsh:Medicine ,Hand-foot-and-mouth disease ,lcsh:Infectious and parasitic diseases ,Southeast asia ,stomatognathic system ,intravenous immunoglobulin ,medicine ,Humans ,lcsh:RC109-216 ,Intensive care medicine ,enterovirus 71 ,Asia, Southeastern ,Randomized Controlled Trials as Topic ,Foot-and-mouth disease ,enterovirus ,business.industry ,lcsh:R ,Immunoglobulins, Intravenous ,Online Report ,medicine.disease ,Southeast Asia ,Surgery ,Clinical trial ,Workshop on Use of Intravenous Immunoglobulin in Hand, Foot and Mouth Disease in Southeast Asia ,Infectious Diseases ,Clinical research ,Infectious disease (medical specialty) ,Inclusion and exclusion criteria ,Hand, Foot and Mouth Disease ,business - Abstract
A randomized, placebo-controlled clinical trial is needed to determine efficacy and safety of this treatment method., The South East Asia Infectious Disease Clinical Research Network convened subject matter experts at a workshop to make consensus recommendations for study design of a clinical trial for use of intravenous immunoglobulin (IVIg) in severe hand, foot and mouth disease (HFMD). HFMD is a highly contagious emerging infection among children in the region, a small proportion of whom develop neurologic and cardiopulmonary complications with high case-fatality rates. The use of IVIg for treatment of severe disease is widespread and a part of local, national, and international guidelines, but no clinical evidence warrants the use of this drug, which is expensive and has potentially serious side effects. During a 2-day workshop in March 2014, a group of HFMD experts reviewed the current evidence related to use of IVIg in HFMD and discussed potential study design, feasibility, inclusion and exclusion criteria, sample size, primary and secondary endpoints, and subsidiary studies for a randomized, placebo-controlled trial.
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- 2015
34. Clinical evaluation of dengue and identification of risk factors for severe disease: protocol for a multicentre study in 8 countries.
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Jaenisch, Thomas, Dong Thi Hoai Tam, Nguyen Tan Thanh Kieu, Tran Van Ngoc, Nguyen Tran Nam, Nguyen Van Kinh, Yacoub, Sophie, Ngoun Chanpheaktra, Kumar, Varun, Lum Chai See, Lucy, Sathar, Jameela, Pleités Sandoval, Ernesto, Marón Alfaro, Gabriela Maria, Safitri Laksono, Ida, Mahendradhata, Yodi, Sarker, Malabika, Ahmed, Firoz, Caprara, Andrea, Souza Benevides, Bruno, and Marques, Ernesto T. A.
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DENGUE ,DIAGNOSIS of fever ,FEBRILE neutropenia ,FEVER ,HEMORRHAGE ,OUTPATIENT services in hospitals ,PATIENTS ,DISEASE risk factors ,COMPARATIVE studies ,DIFFERENTIAL diagnosis ,FLAVIVIRUSES ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,DISEASE management ,EVALUATION research ,DIAGNOSIS - Abstract
Background: The burden of dengue continues to increase globally, with an estimated 100 million clinically apparent infections occurring each year. Although most dengue infections are asymptomatic, patients can present with a wide spectrum of clinical symptoms ranging from mild febrile illness through to severe manifestations of bleeding, organ impairment, and hypovolaemic shock due to a systemic vascular leak syndrome. Clinical diagnosis of dengue and identification of which patients are likely to develop severe disease remain challenging. This study aims to improve diagnosis and clinical management through approaches designed a) to differentiate between dengue and other common febrile illness within 72 h of fever onset, and b) among patients with dengue to identify markers that are predictive of the likelihood of evolving to a more severe disease course.Method/design: This is a prospective multi-centre observational study aiming to enrol 7-8000 participants aged ≥ 5 years presenting with a febrile illness consistent with dengue to outpatient health facilities in 8 countries across Asia and Latin America. Patients presenting within 72 h of fever onset who do not exhibit signs of severe disease are eligible for the study. A broad range of clinical and laboratory parameters are assessed daily for up to 6 days during the acute illness, and also at a follow up visit 1 week later.Discussion: Data from this large cohort of patients, enrolled early with undifferentiated fever, will be used to develop a practical diagnostic algorithm and a robust clinical case definition for dengue. Additionally, among patients with confirmed dengue we aim to identify simple clinical and laboratory parameters associated with progression to a more severe disease course. We will also investigate early virological and serological correlates of severe disease, and examine genetic associations in this large heterogeneous cohort. In addition the results will be used to assess the new World Health Organization classification scheme for dengue in practice, and to update the guidelines for "Integrated Management of Childhood Illness" used in dengue-endemic countries.Trial Registration: NCT01550016. Registration Date: March 7, 2012. [ABSTRACT FROM AUTHOR]- Published
- 2016
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35. IDENTIFICATION OF CLINICAL AND LABORATORY PARAMETERS THAT DISTINGUISH BETWEEN DENGUE AND NON-DENGUE ILLNESS WITHIN THE FIRST 72 HOURS OF FEVER
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Jaenisch, Thomas, Rosenberger, Kerstin, Phung Khanh Lam, Nguyen Tran Nam, Kumar, Varun, See, Lucy Lum Chai, Gabriela Maron, Laksono, Ida Safitri, Ahmed, Firoz, Brasil, Patricia, Tovar, Robert, Wirths, Marius, Guzman, Maria G., Nguyen Than Ha Quyen, Simmons, Cameron P., Wolbers, Marcel, and Wills, Bridget
36. Shape and displacement measurement of discontinuous surfaces by combining fringe projection and digital image correlation.
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Nguyen, Tran Nam, Huntley, Jonathan M., Burguete, Richard L., and Coggrave, C. Russell
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DIGITAL image processing , *OPTICAL images , *DIGITAL images , *THREE-dimensional display systems , *CAMERAS , *RIGID bodies - Abstract
We describe how a shape-measurement system (SMS) based on fringe projection can be combined with a two-dimensional digital image correlation (DIC) technique to accurately measure both surface profile and displacement fields at the same time. Whereas the measurement of all three displacement components by traditional DIC requires the use of at least two cameras, the approach presented here provides the full three-dimensional (3-D) displacement field from a single-camera, single-projector SMS with no additional hardware requirements. Furthermore, the single-pixel spatial resolution of the fringe projection technique can be exploited to prevent the correlation peak-splitting phenomenon that occurs when a DIC subimage straddles a global geometrical discontinuity. Thus, unlike traditional 3-D DIC techniques, the proposed method can measure displacement fields on discontinuous surfaces as easily as on smooth ones. Details of the algorithm are given together with experimental results of a rigid-body translation test. Measurements made during a routine fatigue test on a part of a wing panel are also presented. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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