1. Mouse eosinophil‐associated ribonuclease‐2 exacerbates the allergic response.
- Author
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Nguyen, Linh Manh, Kanda, Akira, Kamioka, Yuji, Tokuhiro, Keizo, Kobayashi, Yoshiki, Yun, Yasutaka, Bui, Dan Van, Chu, Hanh Hong, Le, Nhi Kieu Thi, Suzuki, Kensuke, Mitani, Akitoshi, Shimamura, Akihiro, Fukui, Kenta, Dombrowicz, David, and Iwai, Hiroshi
- Subjects
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GRANTS in aid (Public finance) , *HOUSE dust mites , *HOMOLOGY (Biology) , *TECHNICAL drawing , *HEMATOXYLIN & eosin staining , *PULMONARY eosinophilia - Abstract
The article discusses the role of mouse eosinophil-associated ribonuclease-2 (mEAR2) in allergic asthma. The study found that mEAR2 is not necessary for the development and function of eosinophils at rest, but it plays a crucial role in allergic airway inflammation (AAI). The absence of mEAR2 in mice resulted in decreased lung inflammation, reduced eosinophil recruitment, and diminished airway hyperresponsiveness. Additionally, mEAR2 was found to enhance the production of type 2 cytokines and IgE, contributing to the allergic response. The findings suggest that mEAR2 could serve as a potential biomarker for asthma management and a therapeutic target. [Extracted from the article]
- Published
- 2024
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