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3. Continued Circulation of Highly Pathogenic H5 Influenza Viruses in Vietnamese Live Bird Markets in 2018–2021.

Author

Guan, Lizheng, Babujee, Lavanya, Browning, Victoria L., Presler, Robert, Pattinson, David, Nguyen, Hang Le Khanh, Hoang, Vu Mai Phuong, Le, Mai Quynh, van Bakel, Harm, Neumann, Gabriele, and Kawaoka, Yoshihiro

Subjects
INFLUENZA viruses, AVIAN influenza A virus, PATHOGENIC viruses, PLANT viruses, AMINO acids
Abstract

We isolated 77 highly pathogenic avian influenza viruses during routine surveillance in live poultry markets in northern provinces of Vietnam from 2018 to 2021. These viruses are of the H5N6 subtype and belong to HA clades 2.3.4.4g and 2.3.4.4h. Interestingly, we did not detect viruses of clade 2.3.4.4b, which in recent years have dominated in different parts of the world. The viruses isolated in this current study do not encode major determinants of mammalian adaptation (e.g., PB2-E627K or PB1-D701N) but possess amino acid substitutions that may affect viral receptor-binding, replication, or the responses to human antiviral factors. Several of the highly pathogenic H5N6 virus samples contained other influenza viruses, providing an opportunity for reassortment. Collectively, our study demonstrates that the highly pathogenic H5 viruses circulating in Vietnam in 2018–2021 were different from those in other parts of the world, and that the Vietnamese H5 viruses continue to evolve through mutations and reassortment. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Safety and Immunogenicity of Nanocovax, a SARS-CoV-2 Recombinant Spike Protein Vaccine

Author

Nguyen, Thuy Phuong, primary, Do, Quyet, additional, Lan, Phan Trong, additional, Dinh, Duc Viet, additional, Khong, Hiep, additional, Hoang, Luong Van, additional, Nguyen, Thuong Vu, additional, Ngoc, Hung Pham, additional, Chu, Men Van, additional, Nguyen, Toan Trong, additional, Pham, Quang Duy, additional, Le, Tri Minh, additional, Trang, Tuyen Thi Ngoc, additional, Dinh, Thanh Thi, additional, Vo, Thuong Van, additional, Vu, Thao Thi Thu, additional, Nguyen, Quynh Bao Phuong, additional, Phan, Vuong Tan, additional, Nguyen, Luong Viet, additional, Nguyen, Giang Truong, additional, Tran, Phong Minh, additional, Nghiem, Thuan Duc, additional, Tran, Tien Viet, additional, Nguyen, Tien Gia, additional, Tran, Tuynh Quang, additional, Nguyen, Linh Tung, additional, Do, Anh Tuan, additional, Nguyen, Dung Dang, additional, Ho, Son Anh, additional, Nguyen, Viet Thanh, additional, Pham, Dung T., additional, Tran, Hieu Ba, additional, Vu, Son Tung, additional, Vu, Hoan Ngoc, additional, Hoang, Cuong Xuan, additional, Hoang, Su Xuan, additional, Do, Trung Minh, additional, Nguyen, Xuan Thanh, additional, Le, Giang Quynh, additional, Tran, Ton, additional, Cao, Thang Minh, additional, Dao, Huy Manh, additional, Nguyen, Thao Thi Thanh, additional, Doan, Uyen Y., additional, Vy, Le Thi Tuong, additional, Tran, Linh Phuong, additional, Nguyen, Ngoc Minh, additional, Nguyen, Ngoc Thu, additional, Pham, Hang Thi Thu, additional, Nguyen, Quan Hoang, additional, Nguyen, Hieu Trung, additional, Nguyen, Hang Le Khanh, additional, Tran, Vinh The, additional, Tran, Mai Thi Nhu, additional, Nguyen, Truc Thi Thanh, additional, Ha, Phat Tan, additional, Huynh, Hieu Trong, additional, Nguyen, Khanh Duy, additional, Ung, Thuan Trong, additional, Doan, Chung Chinh, additional, and Do, Si Minh, additional

Published
2021
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7. Antibiotic-resistant Escherichia coli isolated from urban rodents in Hanoi, Vietnam

Author

LE HUY, Hoang, primary, KOIZUMI, Nobuo, additional, UNG, Trang Thi Hong, additional, LE, Thanh Thi, additional, NGUYEN, Hang Le Khanh, additional, HOANG, Phuong Vu Mai, additional, NGUYEN, Cam Nhat, additional, KHONG, Tuan Minh, additional, HASEBE, Futoshi, additional, HAGA, Takeshi, additional, LE, Mai Thi Quynh, additional, HIRAYAMA, Kazuhiro, additional, and MIURA, Kozue, additional

Published
2020
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8. Isolation of Highly Pathogenic H5N1 Influenza Viruses in 2009–2013 in Vietnam

Author

Zhong, Gongxun, primary, Fan, Shufang, additional, Lopes, Tiago J. S., additional, Le, Mai Quynh, additional, van Bakel, Harm, additional, Dutta, Jayeeta, additional, Smith, Gavin J. D., additional, Jayakumar, Jayanthi, additional, Nguyen, Hang Le Khanh, additional, Hoang, Phuong Vu Mai, additional, Halfmann, Peter, additional, Hatta, Masato, additional, Su, Yvonne C. F., additional, Neumann, Gabriele, additional, and Kawaoka, Yoshihiro, additional

Published
2019
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9. Molecular epidemiology of Leptospira interrogans in Rattus norvegicus in Hanoi, Vietnam

Author

Koizumi, Nobuo, primary, Miura, Kozue, additional, Sanai, Yu, additional, Takemura, Taichiro, additional, Ung, Trang Thi Hong, additional, Le, Thanh Thi, additional, Hirayama, Kazuhiro, additional, Hasebe, Futoshi, additional, Nguyen, Hang Le Khanh, additional, Hoang, Phuong Vu Mai, additional, Nguyen, Cam Nhat, additional, Khong, Tuan Minh, additional, Le, Mai Thi Quynh, additional, Hoang, Ha Thi Thu, additional, and Ohnishi, Makoto, additional

Published
2019
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10. Occurrence of the Omicron variant of SARS-CoV-2 in northern Viet Nam in early 2022.

Author

Ung TTH, Hoang PVM, Nguyen SV, Nguyen HLK, Nguyen PTK, Phan DT, Le TT, Nguyen AP, Hasebe F, and Le MTQ

Subjects
Humans, SARS-CoV-2 genetics, Vietnam epidemiology, Genomics, COVID-19 epidemiology
Abstract

The Omicron variant caused a surge of infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Viet Nam in early 2022, signalling community transmission. We report on active whole-genome sequencing surveillance of positive SARS-CoV-2 samples collected at that time in northern Viet Nam from international arrivals and community clusters. We used an amplicon protocol developed with 14 polymerase chain reaction products and the Illumina iSeq 100 platform. Overall, 213 nasopharyngeal or throat swabs were analysed, of which 172 samples were identified with the Omicron variant. Of these, 80 samples were collected from community cases in February 2022, among which 59 samples were sublineage BA.2 and one sample was the recombinant XE variant. Our results indicated that Omicron had replaced Delta as the dominant variant in a very short period of time and that continuously conducting active whole-genome sequencing surveillance is necessary in monitoring the evolution and genomic diversity of SARS-CoV-2 in Viet Nam., ((c) 2022 The authors; licensee World Health Organization.)

Published
2022
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