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The two most urgent and interlinked environmental challenges humanity faces are climate change and biodiversity loss. We are entering a pivotal decade for both the international biodiversity and climate change agendas with the sharpening of ambitious strategies and targets by the Convention on Biological Diversity and the United Nations Framework Convention on Climate Change. Within their respective Conventions, the biodiversity and climate interlinked challenges have largely been addressed separately. There is evidence that conservation actions that halt, slow or reverse biodiversity loss can simultaneously slow anthropogenic mediated climate change significantly. This review highlights conservation actions which have the largest potential for mitigation of climate change. We note that conservation actions have mainly synergistic benefits and few antagonistic trade-offs with climate change mitigation. Specifically, we identify direct co-benefits in 14 out of the 21 action targets of the draft post-2020 global biodiversity framework of the Convention on Biological Diversity, notwithstanding the many indirect links that can also support both biodiversity conservation and climate change mitigation. These relationships are context and scale-dependent; therefore, we showcase examples of local biodiversity conservation actions that can be incentivized, guided and prioritized by global objectives and targets. The close interlinkages between biodiversity, climate change mitigation, other nature's contributions to people and good quality of life are seldom as integrated as they should be in management and policy. This review aims to re-emphasize the vital relationships between biodiversity conservation actions and climate change mitigation in a timely manner, in support to major Conferences of Parties that are about to negotiate strategic frameworks and international goals for the decades to come.

Transformative governance is key to addressing the global environmental crisis. We explore how transformative governance of complex biodiversity-climate-society interactions can be achieved, drawing on the first joint report between the Intergovernmental Panel on Climate Change and the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services to reflect on the current opportunities, barriers, and challenges for transformative governance. We identify principles for transformative governance under a biodiversity-climate-society nexus frame using four case studies: forest ecosystems, marine ecosystems, urban environments, and the Arctic. The principles are focused on creating conditions to build multifunctional interventions, integration, and innovation across scales; coalitions of support; equitable approaches; and positive social tipping dynamics. We posit that building on such transformative governance principles is not only possible but essential to effectively keep climate change within the desired 1.5 degrees Celsius global mean temperature increase, halt the ongoing accelerated decline of global biodiversity, and promote human well-being.

Background: The trans-membrane protease serine 2 (TMPRSS2) is essential for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry and infection. Efficacy and safety of TMPRSS2 inhibitors in patients with coronavirus disease 2019 (Covid-19) have not been evaluated in randomized trials. Methods: We conducted an investigator-initiated, double-blind, randomized, placebo-controlled multicenter trial in patients hospitalized with confirmed SARS-CoV-2 infection from April 4, to December 31, 2020. Within 48 h of admission, participants were randomly assigned in a 2:1 ratio to receive the TMPRSS2 inhibitor camostat mesilate 200 mg three times daily for 5 days or placebo. The primary outcome was time to discharge or clinical improvement measured as ≥2 points improvement on a 7-point ordinal scale. Other outcomes included 30-day mortality, safety and change in oropharyngeal viral load. ClinicalTrials.gov Identifier: NCT04321096. EudraCT Number: 2020-001,200-42. Findings: 137 patients were assigned to receive camostat mesilate and 68 to placebo. Median time to clinical improvement was 5 days (interquartile range [IQR], 3 to 7) in the camostat group and 5 days (IQR, 2 to 10) in the placebo group (P = 0·31). The hazard ratio for 30-day mortality in the camostat compared with the placebo group was 0·82 (95% confidence interval [CI], 0·24 to 2·79; P = 0·75). The frequency of adverse events was similar in the two groups. Median change in viral load from baseline to day 5 in the camostat group was -0·22 log10 copies/mL (p <0·05) and -0·82 log10 in the placebo group (P <0·05). Interpretation: Under this protocol, camostat mesilate treatment was not associated with increased adverse events during hospitalization for Covid-19 and did not affect time to clinical improvement, progression to ICU admission or mortality.

Multiple anthropogenic challenges threaten nature's contributions to human well-being. Agricultural expansion and conventional intensification are degrading biodiversity and ecosystem functions, thereby undermining the natural foundations on which agriculture is itself built. Averting the worst effects of global environmental change and assuring ecosystem benefits, requires a transformation of agriculture. Alternative agricultural systems to conventional intensification exist, ranging from adjustments to efficiency (e.g. sustainable intensification) to a redesign (e.g. ecological intensification, climate-smart agriculture) of the farm management system. These alternatives vary in their reliance on nature or technology, the level of systemic change required to operate, and impacts on biodiversity, landscapes and agricultural production. Different socio-economic, ecological and political settings mean there is no universal solution, instead there are a suite of interoperable practices that can be adapted to different contexts to maximise efficiency, sustainability and resilience. Social, economic, technological and demographic issues will influence the form of sustainable agriculture and effects on landscapes and biodiversity. These include: (1) the socio-technical-ecological architecture of agricultural and food systems and trends such as urbanisation in affecting the mode of production, diets, lifestyles and attitudes; (2) emerging technologies, such as gene editing, synthetic biology and 3D bioprinting of meat; and (3) the scale or state of the existing farm system, especially pertinent for smallholder agriculture. Agricultural transformation will require multifunctional landscape planning with cross-sectoral and participatory management to avoid unintended consequences and ultimately depends on people's capacity to accept new ways of operating in response to the current environmental crisis.

1. Humanity is on a deeply unsustainable trajectory. We are exceeding planetary boundaries and unlikely to meet many international sustainable development goals and global environmental targets. Until recently, there was no broadly accepted framework of interventions that could ignite the transformations needed to achieve these desired targets and goals. 2. As a component of the IPBES Global Assessment, we conducted an iterative expert deliberation process with an extensive review of scenarios and pathways to sustainability, including the broader literature on indirect drivers, social change and sustainability transformation. We asked, what are the most important elements of pathways to sustainability? 3. Applying a social-ecological systems lens, we identified eight priority points for intervention (leverage points) and five overarching strategic actions and priority interventions (levers), which appear to be key to societal transformation. The eight leverage points are: (1) Visions of a good life, (2) Total consumption and waste, (3) Latent values of responsibility, (4) Inequalities, (5) Justice and inclusion in conservation, (6) Externalities from trade and other telecouplings, (7) Responsible technology, innovation and investment, and (8) Education and knowledge generation and sharing. The five intertwined levers can be applied across the eight leverage points and more broadly. These include: (A) Incentives and capacity building, (B) Coordination across sectors and jurisdictions, (C) Pre-emptive action, (D) Adaptive decision-making and (E) Environmental law and implementation. The levers and leverage points are all non-substitutable, and each enables others, likely leading to synergistic benefits. 4. Transformative change towards sustainable pathways requires more than a simple scaling-up of sustainability initiatives-it entails addressing these levers and leverage points to change the fabric of legal, political, economic and other social systems. These levers a