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2. Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy

Author

Tan, Chia Jie, Lim, Sheree Wan Ting, Toh, Yi Long, Ng, Terence, Yeo, Angie, Shwe, Maung, Foo, Koon Mian, Chu, Pat, Jain, Amit, Koo, Si-Lin, Dent, Rebecca A, Ng, Raymond Chee Hui, Yap, Yoon Sim, Lim, Elaine H, Loh, Kiley Wei-Jen, Chay, Wen Yee, Lee, Guek Eng, Tan, Tira Jing Ying, Beh, Sok Yuen, Wong, Mabel, Chan, Jack Junjie, Khor, Chiea Chuen, Ho, Han Kiat, and Chan, Alexandre

Subjects
Biomedical and Clinical Sciences, Neurosciences, Human Genome, Brain Disorders, Clinical Research, Genetics, Cancer, Alleles, Antineoplastic Agents, Anxiety, Brain-Derived Neurotrophic Factor, Cognitive Dysfunction, Fatigue, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Prevalence, Reproducibility of Results, Cancer-related cognitive impairment, BDNF, Genetic polymorphism, Breast cancer, Chemotherapy, Psychology, Cognitive Sciences, Neurology & Neurosurgery, Biochemistry and cell biology
Abstract

Cancer-related cognitive impairment (CRCI) adversely affects cancer patients. We had previously demonstrated that the BDNF Val66Met genetic polymorphism is associated with lower odds of subjective CRCI in the multitasking and verbal ability domains among breast cancer patients receiving chemotherapy. To further assess our previous findings, we evaluated the association of BDNF Val66Met polymorphism with subjective and objective CRCI in a temporally separate cohort of patients and pooled findings from both the original (n = 145) and current (n = 193) cohorts in a meta-analysis. Subjective CRCI was assessed using FACT-Cog. Objective CRCI was evaluated using computerized neuropsychological tests. Genotyping was carried out using Sanger sequencing. The association of BDNF Val66Met genotypes and CRCI was examined with logistic regression. A fixed-effect meta-analysis was conducted using the inverse variance method. In the meta-analysis (n = 338), significantly lower odds of CRCI were associated with Met allele carriers based on the global FACT-Cog score (OR = 0.52, 95% CI 0.29-0.94). Furthermore, Met allele carriers were at lower odds of developing impairment in the domains of memory (OR = 0.34, 95% CI: 0.17-0.70), multitasking (OR = 0.33, 95% CI: 0.18-0.59), and verbal ability (OR = 0.46, 95% CI: 0.24-0.88). Consistent with the previous study, lower odds of subjective CRCI among patients with the BDNF Met allele was observed after adjusting for potential confounders in the multitasking (OR = 0.30, 95% CI: 0.14-0.67) domain. In conclusion, carriers of the BDNF Met allele were protected against global subjective CRCI, particularly in the domains of memory, multitasking, and verbal ability. Our findings further contribute to the understanding of CRCI pathophysiology.

Published
2019

5. Cross‐Ancestry Genome‐Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations

Author

Khor, Chiea Chuen, primary, Winter, Stefan, additional, Sutiman, Natalia, additional, Mürdter, Thomas E., additional, Chen, Sylvia, additional, Lim, Joanne Siok Liu, additional, Li, Zheng, additional, Li, Jingmei, additional, Sim, Kar Seng, additional, Ganchev, Boian, additional, Eccles, Diana, additional, Eccles, Bryony, additional, Tapper, William, additional, Zgheib, Nathalie K., additional, Tfayli, Arafat, additional, Ng, Raymond Chee Hui, additional, Yap, Yoon Sim, additional, Lim, Elaine, additional, Wong, Mabel, additional, Wong, Nan Soon, additional, Ang, Peter Cher Siang, additional, Dent, Rebecca, additional, Tremmel, Roman, additional, Klein, Kathrin, additional, Schaeffeler, Elke, additional, Zhou, Yitian, additional, Lauschke, Volker M., additional, Eichelbaum, Michel, additional, Schwab, Matthias, additional, Brauch, Hiltrud B., additional, Chowbay, Balram, additional, and Schroth, Werner, additional

Published
2023
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10. Complementary Sequential Circulating Tumor Cell (CTC) and Cell-Free Tumor DNA (ctDNA) Profiling Reveals Metastatic Heterogeneity and Genomic Changes in Lung Cancer and Breast Cancer

Author

Kong, Say Li, primary, Liu, Xingliang, additional, Tan, Swee Jin, additional, Tai, Joyce A., additional, Phua, Ler Yee, additional, Poh, Huay Mei, additional, Yeo, Trifanny, additional, Chua, Yong Wei, additional, Haw, Yu Xuan, additional, Ling, Wen Huan, additional, Ng, Raymond Chee Hui, additional, Tan, Tira J., additional, Loh, Kiley Wei Jen, additional, Tan, Daniel Shao-Weng, additional, Ng, Quan Sing, additional, Ang, Mei Kim, additional, Toh, Chee Keong, additional, Lee, Yi Fang, additional, Lim, Chwee Teck, additional, Lim, Tony Kiat Hon, additional, Hillmer, Axel M., additional, Yap, Yoon Sim, additional, and Lim, Wan-Teck, additional

Published
2021
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12. Detection and prognostic relevance of circulating tumour cells (CTCs) in Asian breast cancers using a label-free microfluidic platform

Author

Yap, Yoon-Sim, primary, Leong, Man Chun, additional, Chua, Yong Wei, additional, Loh, Kiley Wei Jen, additional, Lee, Guek Eng, additional, Lim, Elaine Hsuen, additional, Dent, Rebecca, additional, Ng, Raymond Chee Hui, additional, Lim, John Heng-Chi, additional, Singh, Garima, additional, Tan, Angela, additional, Guan, Guofeng, additional, Wu, Andrew, additional, Lee, Yi Fang, additional, Bhagat, Ali Asgar S., additional, and Lim, Darren Wan-Teck, additional

Published
2019
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13. Detection of genomic alterations in breast cancer with circulating tumour DNA sequencing

Author

Kleftogiannis, Dimitrios, primary, Ho, Danliang, additional, Liew, Jun Xian, additional, Poon, Polly, additional, Gan, Anna, additional, Ng, Raymond Chee-Hui, additional, Tan, Benita Kiat-Tee, additional, Tay, Kiang Hiong, additional, Lim, Swee-Ho, additional, Tan, Gek San, additional, Shih, Chih Chuan, additional, Lim, Tony, additional, Lee, Ann Siew-Gek, additional, Tan, Iain, additional, Yap, Yoon-Sim, additional, and Ng, Sarah, additional

Published
2019
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14. Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy

Author

Tan, Chia Jie, primary, Lim, Sheree Wan Ting, additional, Toh, Yi Long, additional, Ng, Terence, additional, Yeo, Angie, additional, Shwe, Maung, additional, Foo, Koon Mian, additional, Chu, Pat, additional, Jain, Amit, additional, Koo, Si-Lin, additional, Dent, Rebecca A., additional, Ng, Raymond Chee Hui, additional, Yap, Yoon Sim, additional, Lim, Elaine H., additional, Loh, Kiley Wei-Jen, additional, Chay, Wen Yee, additional, Lee, Guek Eng, additional, Tan, Tira Jing Ying, additional, Beh, Sok Yuen, additional, Wong, Mabel, additional, Chan, Jack Junjie, additional, Khor, Chiea Chuen, additional, Ho, Han Kiat, additional, and Chan, Alexandre, additional

Published
2018
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15. Evaluation of three polygenic risk score models for the prediction of breast cancer risk in Singapore Chinese

Author

Chan, Claire Hian Tzer, primary, Munusamy, Prabhakaran, additional, Loke, Sau Yeen, additional, Koh, Geok Ling, additional, Yang, Audrey Zhi Yi, additional, Law, Hai Yang, additional, Yoon, Chui Sheun, additional, Wong, Chow Yin, additional, Yong, Wei Sean, additional, Wong, Nan Soon, additional, Ng, Raymond Chee Hui, additional, Ong, Kong Wee, additional, Madhukumar, Preetha, additional, Oey, Chung Lie, additional, Ho, Gay Hui, additional, Tan, Puay Hoon, additional, Tan, Min Han, additional, Ang, Peter, additional, Yap, Yoon Sim, additional, and Lee, Ann Siew Gek, additional

Published
2018
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16. Abstract 5008: Elucidating HER2 molecular heterogeneity of circulating tumor cells among breast cancer patients

Author

Leong, Man Chun, primary, Lim, Tse Hui, additional, Tan, Chye Ling, additional, Chua, Yong Wei, additional, Lim, Elaine Hsuen, additional, Loh, Kiley Wei Jen, additional, Lee, Guek Eng, additional, Dent, Rebecca, additional, Ng, Raymond Chee Hui, additional, Wu, Andrew, additional, Lim, Wan-Teck, additional, Lim, Alvin Soon-Tiong, additional, and Yap, Yoon-Sim, additional

Published
2016
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17. Association of CYP2C19* 2 and associated haplotypes with lower norendoxifen concentrations in tamoxifen-treated Asian breast cancer patients.

Author

Lim, Joanne Siok Liu, Sutiman, Natalia, Muerdter, Thomas E., Singh, Onkar, Cheung, Yin Bun, Ng, Raymond Chee Hui, Yap, Yoon Sim, Wong, Nan Soon, Ang, Peter Cher Siang, Dent, Rebecca, Schroth, Werner, Schwab, Matthias, and Chowbay, Balram

Subjects
TAMOXIFEN, METABOLITES, LIQUID chromatography, MASS spectrometry, BREAST cancer patients
Abstract

Copyright of British Journal of Clinical Pharmacology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016
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