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The thesis is focused on preparing pyrazolopyrimidines structurally similar to biogenic purines and evaluating their anticancer properties. The fused heterocyclic systems related to the pyrazolopyrimidine skeleton also fall within the area of the thesis's interest. Several new efficient methods for the preparation of these compounds were developed. More than 150 novel compounds were prepared and studied. Some promising antileukemic compounds were identified.

The first and foremost requisite of caring is to treat patients as persons, not as diseases or bed-numbers. A qualitative study was conducted to explore the perception of good care from the point of view of 13 terminally ill patientsand 8 caregiving family members of the University of Malaya Medical Centre, Kuala Lumpur, Malaysia. The results were thematically analyzed. Five basic themes were generated: (1) Attitude, (2) Behaviour, (3) Communication, (4) Duty and (5) Environment—ABCDE. The results may provide useful insight into the art of caring.

The shrimp growth and production can be measured through several components such as the harvest ton, mean body weight, survival rate and feed conversion ratio. According to previous studies, the shrimp feed conversion ratio should have a positive relationship with their mean body weight. Nevertheless, in real scenario, high feed conversion ratio does not necessarily implies maximum increment of mean body weight. The measurement of those components usually can be influenced by many factors such as climates, stocking density and day of culture. This study in particular explores the effect of climates on productivity of the shrimp species, Penaeus Vannamei and investigates whether feed conversion ratio influences the mean body weight when stocking are done at different climate season. First, the one-way MANOVA was used to measure the effect between the climate seasons and P. Vannamei production. Then, the regression analysis was apply to measure the relationship between P. Vannamei feed conversion ratio and mean body weight for different climate seasons. Finally, to find the best season for sustainable production of P. Vannamei, the average score of P. Vannamei production was measured according to their stocking climate season. Result revealed that dry season was more favorable for the growth and production of P. Vannamei compared to wet season.

Stress among medical students has been well documented as a significant problem. The objective of this study is to compare the stress levels and its associated stressors between public and private university medical students. A cross-sectional study design was carried out using universal sampling in both University Sultan Zainal Abidin (UniSZA) (245) and UCSI University (315) medical students year 1–5, from 2015 till 2016. Data was collected using a self-administered questionnaire including sociodemography, Medical Student Stress Questionnaire and General Health Questionnaire. Data entry and analysis were done using SPSS version 20.0 software. The studies reported a mean age of 23.02 years (SD 1.78) and 21.8 years (SD 1.50) at UCSI University and UniSZA respectively. UCSI University had majority Chinese medical students (52.1%) while UniZSA had majority (66.5) Malay medical students. The stress prevalence was 42.2% and 33.1% among UCSI University and UniZSA medical students respectively. UCSI University had a higher mean stress score of 4.66 (SD 3.4) compared to UniZSA 2.91 (SD 2.98), which was statistically different (p

Introduction: Medical education has been considered highly stressful to medical students. It not only affects medical students’ physical and mental health but chronic stress can impair academic performance, personal and professional development, leading to unsatisfactory patient care. The objective of this study is to compare the coping strategies practiced and its association with stress between medical students from a private and public university. Materials and Methods: This was a cross-sectional study conducted in a public and private university namely, University Sultan Zainal Abidin (UniZSA) and UCSI University (UCSI) respectively. A total of 245 medical students from UniZSA and 315 medical students from UCSI, from year 1 to year 5 participated in this study. This study was carried out between 2015 till 2016. A universal sampling method was used. A self-administered questionnaires comprising of 3 sections namely sociodemographic information, 12 item validated General Health Questionnaire (GHQ-12) and a 28 item validated Brief Cope Inventory was used in this study. Data entry and analysis were done using SPSS version 20.0 software. Results: The prevalence of stress was higher (42.2%) among UCSI University medical students compared to University Sultan Zainal Abidin medical students (33.1%). The commonly practised coping strategies in both universities were religion, active coping, acceptance, planning, and positive reframing. The negative coping strategies behavioural disengagement and substance abuse were the least practised in both universities. The associated coping strategies with stress were denial (?2 5.740; P