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2. Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study

Author

Feys, S., Vanmassenhove, S., Kraisin, S., Yu, K., Jacobs, Cato, Boeckx, B., Cambier, S., Cunha, C., Debaveye, Y., Gonçalves, S.M., Hermans, G., Humblet-Baron, S., Jansen, Sander, Lagrou, K., Meersseman, P., Neyts, J., Peetermans, M., Rocha-Pereira, J., Schepers, R., Spalart, V., Starick, M.R., Thevissen, K., Brussel, T. van, Buyten, T. Van, Mol, P. Van, Vandenbriele, C., Vanderbeke, L., Wauters, E., Wilmer, A., Weyenbergh, J. Van, Veerdonk, F.L. van de, Carvalho, A., Proost, P., Martinod, K., Lambrechts, D., Wauters, J., Feys, S., Vanmassenhove, S., Kraisin, S., Yu, K., Jacobs, Cato, Boeckx, B., Cambier, S., Cunha, C., Debaveye, Y., Gonçalves, S.M., Hermans, G., Humblet-Baron, S., Jansen, Sander, Lagrou, K., Meersseman, P., Neyts, J., Peetermans, M., Rocha-Pereira, J., Schepers, R., Spalart, V., Starick, M.R., Thevissen, K., Brussel, T. van, Buyten, T. Van, Mol, P. Van, Vandenbriele, C., Vanderbeke, L., Wauters, E., Wilmer, A., Weyenbergh, J. Van, Veerdonk, F.L. van de, Carvalho, A., Proost, P., Martinod, K., Lambrechts, D., and Wauters, J.

Abstract

Contains fulltext : 304846.pdf (Publisher’s version ) (Open Access), BACKGROUND: COVID-19-associated pulmonary aspergillosis (CAPA) is a severe superinfection with the fungus Aspergillus affecting patients who are critically ill with COVID-19. The pathophysiology and the role of neutrophil extracellular traps (NETs) in this infection are largely unknown. We aimed to characterise the immune profile, with a focus on neutrophils and NET concentrations, of critically ill patients with COVID-19, with or without CAPA. METHODS: We conducted a single-centre, retrospective, observational study in two patient cohorts, both recruited at University Hospitals Leuven, Belgium. We included adults aged 18 years or older who were admitted to the intensive care unit because of COVID-19 between March 31, 2020, and May 18, 2021, and who were included in the previous Contagious trial (NCT04327570). We investigated the immune cellular landscape of CAPA versus COVID-19 only by performing single-cell RNA sequencing (scRNA-seq) on bronchoalveolar lavage fluid. Bronchoalveolar lavage immune cell fractions were compared between patients with CAPA and patients with COVID-19 only. Additionally, we determined lower respiratory tract NET concentrations using biochemical assays in patients aged 18 years and older who were admitted to the intensive care unit because of severe COVID-19 between March 15, 2020, and Dec 31, 2021, for whom bronchoalveolar lavage was available in the hospital biobank. Bronchoalveolar lavage NET concentrations were compared between patients with CAPA and patients with COVID-19 only and integrated with existing data on immune mediators in bronchoalveolar lavage and 90-day mortality. FINDINGS: We performed scRNA-seq of bronchoalveolar lavage on 43 samples from 39 patients, of whom 36 patients (30 male and six female; 14 with CAPA) were included in downstream analyses. We performed bronchoalveolar lavage NET analyses in 59 patients (46 male and 13 female), of whom 26 had CAPA. By scRNA-seq, patients with CAPA had significantly lower neutrophi

Published
2024

3. Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity

Author

Vanderbeke, L., Van Mol, P., Van Herck, Y., De Smet, F., Humblet-Baron, S., Martinod, K., Antoranz, A., Arijs, I., Boeckx, B., Bosisio, F. M., Casaer, M., Dauwe, D., De Wever, W., Dooms, C., Dreesen, E., Emmaneel, A., Filtjens, J., Gouwy, M., Gunst, J., Hermans, G., Jansen, S., Lagrou, K., Liston, A., Lorent, N., Meersseman, P., Mercier, T., Neyts, J., Odent, J., Panovska, D., Penttila, P. A., Pollet, E., Proost, P., Qian, J., Quintelier, K., Raes, J., Rex, S., Saeys, Y., Sprooten, J., Tejpar, S., Testelmans, D., Thevissen, K., Van Buyten, T., Vandenhaute, J., Van Gassen, S., Velásquez Pereira, L. C., Vos, R., Weynand, B., Wilmer, A., Yserbyt, J., Garg, A. D., Matthys, P., Wouters, C., Lambrechts, D., Wauters, E., and Wauters, J.

Published
2021
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5. Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.

Author

Boby, M.L., Fearon, D., Ferla, M., Filep, M., Koekemoer, L., Robinson, M.C., Chodera, J.D., Lee, A.A., London, N., Delft, A. von, Delft, F. von, Achdout, H., Aimon, A., Alonzi, D.S., Arbon, R., Aschenbrenner, J.C., Balcomb, B.H., Bar-David, E., Barr, H., Ben-Shmuel, A., Bennett, J., Bilenko, V.A., Borden, B., Boulet, P., Bowman, G.R., Brewitz, L., Brun, J., Bvnbs, S., Calmiano, M., Carbery, A., Carney, D.W., Cattermole, E., Chang, E., Chernyshenko, E., Clyde, A., Coffland, J.E., Cohen, G., Cole, J.C., Contini, A., Cox, L., Croll, T.I., Cvitkovic, M., Jonghe, S. De, Dias, A., Donckers, K., Dotson, D.L., Douangamath, A., Duberstein, S., Dudgeon, T., Dunnett, L.E., Eastman, P., Erez, N., Eyermann, C.J., Fairhead, M., Fate, G., Fedorov, O., Fernandes, R.S., Ferrins, L., Foster, R., Foster, H., Fraisse, L., Gabizon, R., García-Sastre, A., Gawriljuk, V.O., Gehrtz, P., Gileadi, C., Giroud, C., Glass, W.G., Glen, R.C., Glinert, I., Godoy, A.S., Gorichko, M., Gorrie-Stone, T., Griffen, E.J., Haneef, A., Hassell Hart, S, Heer, J., Henry, M., Hill, M., Horrell, S., Huang, Q.Y.J., Huliak, V.D., Hurley, M.F.D., Israely, T., Jajack, A., Jansen, J, Jnoff, E., Jochmans, D., John, T., Kaminow, B., Kang, L., Kantsadi, A.L., Kenny, P.W., Kiappes, J.L., Kinakh, S.O., Kovar, B., Krojer, T., La, V.N.T., Laghnimi-Hahn, S., Lefker, B.A., Levy, H., Lithgo, R.M., Logvinenko, I.G., Lukacik, P., Macdonald, H.B., MacLean, E.M., Makower, L.L., Malla, T.R., Marples, P.G., Matviiuk, T., McCorkindale, W., McGovern, B.L., Melamed, S., Melnykov, K.P., Michurin, O., Miesen, P., Mikolajek, H., Milne, B.F., Minh, D., Morris, A., Morris, G.M., Morwitzer, M.J., Moustakas, D., Mowbray, C.E., Nakamura, A.M., Neto, J.B., Neyts, J., Nguyen, L, Noske, G.D., Oleinikovas, V., Oliva, G., Overheul, G.J., Owen, C.D., Pai, R., Pan, J., Paran, N., Payne, A.M., Perry, B., Pingle, M., Pinjari, J., Politi, B., Powell, A., Pšenák, V., Pulido, I., Puni, R., Rangel, V.L., Reddi, R.N., Rees, P., Reid, S.P., Reid, L., Resnick, E., Ripka, E.G., Robinson, R.P., Rodriguez-Guerra, J., Rosales, R., Rufa, D.A., Saar, K., Saikatendu, K.S., Salah, E., Schaller, D., Scheen, J., Schiffer, C.A., Schofield, C.J., Shafeev, M., Shaikh, A., Shaqra, A.M., Shi, J., Shurrush, K., Singh, S., Sittner, A., Sjö, P., Skyner, R., Smalley, A., Smeets, B., Smilova, M.D., Solmesky, L.J., Spencer, J., Strain-Damerell, C., Swamy, V., Tamir, H., Taylor, J.C., Tennant, R.E., Thompson, W., Thompson, A., Tomásio, S., Tomlinson, C.W.E., Tsurupa, I.S., Tumber, A., Vakonakis, I., Rij, R.P. van, Vangeel, L., Varghese, F.S., Vaschetto, M., Vitner, E.B., Voelz, V., Volkamer, A., Walsh, M.A., Ward, W., Weatherall, C., Weiss, S., White, K.M., Wild, C.F., Witt, K.D., Wittmann, M., Wright, N., Yahalom-Ronen, Y., Yilmaz, N.K., Zaidmann, D., Zhang, I., Zidane, H., Zitzmann, N., Zvornicanin, S.N., Boby, M.L., Fearon, D., Ferla, M., Filep, M., Koekemoer, L., Robinson, M.C., Chodera, J.D., Lee, A.A., London, N., Delft, A. von, Delft, F. von, Achdout, H., Aimon, A., Alonzi, D.S., Arbon, R., Aschenbrenner, J.C., Balcomb, B.H., Bar-David, E., Barr, H., Ben-Shmuel, A., Bennett, J., Bilenko, V.A., Borden, B., Boulet, P., Bowman, G.R., Brewitz, L., Brun, J., Bvnbs, S., Calmiano, M., Carbery, A., Carney, D.W., Cattermole, E., Chang, E., Chernyshenko, E., Clyde, A., Coffland, J.E., Cohen, G., Cole, J.C., Contini, A., Cox, L., Croll, T.I., Cvitkovic, M., Jonghe, S. De, Dias, A., Donckers, K., Dotson, D.L., Douangamath, A., Duberstein, S., Dudgeon, T., Dunnett, L.E., Eastman, P., Erez, N., Eyermann, C.J., Fairhead, M., Fate, G., Fedorov, O., Fernandes, R.S., Ferrins, L., Foster, R., Foster, H., Fraisse, L., Gabizon, R., García-Sastre, A., Gawriljuk, V.O., Gehrtz, P., Gileadi, C., Giroud, C., Glass, W.G., Glen, R.C., Glinert, I., Godoy, A.S., Gorichko, M., Gorrie-Stone, T., Griffen, E.J., Haneef, A., Hassell Hart, S, Heer, J., Henry, M., Hill, M., Horrell, S., Huang, Q.Y.J., Huliak, V.D., Hurley, M.F.D., Israely, T., Jajack, A., Jansen, J, Jnoff, E., Jochmans, D., John, T., Kaminow, B., Kang, L., Kantsadi, A.L., Kenny, P.W., Kiappes, J.L., Kinakh, S.O., Kovar, B., Krojer, T., La, V.N.T., Laghnimi-Hahn, S., Lefker, B.A., Levy, H., Lithgo, R.M., Logvinenko, I.G., Lukacik, P., Macdonald, H.B., MacLean, E.M., Makower, L.L., Malla, T.R., Marples, P.G., Matviiuk, T., McCorkindale, W., McGovern, B.L., Melamed, S., Melnykov, K.P., Michurin, O., Miesen, P., Mikolajek, H., Milne, B.F., Minh, D., Morris, A., Morris, G.M., Morwitzer, M.J., Moustakas, D., Mowbray, C.E., Nakamura, A.M., Neto, J.B., Neyts, J., Nguyen, L, Noske, G.D., Oleinikovas, V., Oliva, G., Overheul, G.J., Owen, C.D., Pai, R., Pan, J., Paran, N., Payne, A.M., Perry, B., Pingle, M., Pinjari, J., Politi, B., Powell, A., Pšenák, V., Pulido, I., Puni, R., Rangel, V.L., Reddi, R.N., Rees, P., Reid, S.P., Reid, L., Resnick, E., Ripka, E.G., Robinson, R.P., Rodriguez-Guerra, J., Rosales, R., Rufa, D.A., Saar, K., Saikatendu, K.S., Salah, E., Schaller, D., Scheen, J., Schiffer, C.A., Schofield, C.J., Shafeev, M., Shaikh, A., Shaqra, A.M., Shi, J., Shurrush, K., Singh, S., Sittner, A., Sjö, P., Skyner, R., Smalley, A., Smeets, B., Smilova, M.D., Solmesky, L.J., Spencer, J., Strain-Damerell, C., Swamy, V., Tamir, H., Taylor, J.C., Tennant, R.E., Thompson, W., Thompson, A., Tomásio, S., Tomlinson, C.W.E., Tsurupa, I.S., Tumber, A., Vakonakis, I., Rij, R.P. van, Vangeel, L., Varghese, F.S., Vaschetto, M., Vitner, E.B., Voelz, V., Volkamer, A., Walsh, M.A., Ward, W., Weatherall, C., Weiss, S., White, K.M., Wild, C.F., Witt, K.D., Wittmann, M., Wright, N., Yahalom-Ronen, Y., Yilmaz, N.K., Zaidmann, D., Zhang, I., Zidane, H., Zitzmann, N., and Zvornicanin, S.N.

Abstract

Item does not contain fulltext, We report the results of the COVID Moonshot, a fully open-science, crowdsourced, and structure-enabled drug discovery campaign targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease. We discovered a noncovalent, nonpeptidic inhibitor scaffold with lead-like properties that is differentiated from current main protease inhibitors. Our approach leveraged crowdsourcing, machine learning, exascale molecular simulations, and high-throughput structural biology and chemistry. We generated a detailed map of the structural plasticity of the SARS-CoV-2 main protease, extensive structure-activity relationships for multiple chemotypes, and a wealth of biochemical activity data. All compound designs (>18,000 designs), crystallographic data (>490 ligand-bound x-ray structures), assay data (>10,000 measurements), and synthesized molecules (>2400 compounds) for this campaign were shared rapidly and openly, creating a rich, open, and intellectual property-free knowledge base for future anticoronavirus drug discovery.

Published
2023

9. The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern

Author

Abdelnabi, R, Foo, CS, Jochmans, D, Vangeel, L, De Jonghe, S, Augustijns, P, Mols, R, Weynand, B, Wattanakul, T, Hoglund, RM, Tarning, J, Mowbray, CE, Sjö, P, Escudié, F, Scandale, I, Chatelain, E, and Neyts, J

Subjects
Multidisciplinary, Lactams, Mesocricetus, Proline, Viral Protease Inhibitors, SARS-CoV-2, fungi, General Physics and Astronomy, Administration, Oral, COVID-19, General Chemistry, Respiratory Mucosa, Virus Replication, General Biochemistry, Genetics and Molecular Biology, COVID-19 Drug Treatment, Disease Models, Animal, A549 Cells, Leucine, Cricetinae, Chlorocebus aethiops, Nitriles, Animals, Humans, Vero Cells, Coronavirus 3C Proteases
Abstract

There is an urgent need for potent and selective antivirals against SARS-CoV-2. Pfizer developed PF-07321332 (PF-332), a potent inhibitor of the viral main protease (Mpro, 3CLpro) that can be dosed orally and that is in clinical development. We here report that PF-332 exerts equipotent in vitro activity against the four SARS-CoV-2 variants of concerns (VoC) and that it can completely arrest replication of the alpha variant in primary human airway epithelial cells grown at the air-liquid interface. Treatment of Syrian Golden hamsters with PF-332 (250 mg/kg, twice daily) completely protected the animals against intranasal infection with the beta (B.1.351) and delta (B.1.617.2) SARS-CoV-2 variants. Moreover, treatment of SARS-CoV-2 (B.1.617.2) infected animals with PF-332 completely prevented transmission to untreated co-housed sentinels. ispartof: NATURE COMMUNICATIONS vol:13 issue:1 ispartof: location:England status: published

Published
2021

16. Infection of zebrafish larvae with human norovirus and evaluation of the in vivo efficacy of small-molecule inhibitors

Author

Dycke, J. van, Cuvry, A., Knickmann, J., Ny, A., Rakers, S., Taube, S., Witte, P. de, Neyts, J., Rocha-Pereira, J., and Publica

Abstract

We have recently established that human norovirus (HuNoV) replicates efficiently in zebrafish larvae after inoculation of a clinical sample into the yolk, providing a simple and robust in vivo system in which to study HuNoV. In this Protocol Extension, we present a detailed description of virus inoculation by microinjection, subsequent daily monitoring and harvesting of larvae, followed by viral RNA quantification. This protocol can be used to study viral replication of genogroup (G)I and GII HuNoVs in vivo within 3-4 d. Additionally, we describe how to evaluate the in vivo antiviral effect and toxicity of small molecules using HuNoV-infected zebrafish larvae, in multi-well plates and without the need for specific formulations. This constitutes a great advantage for drug discovery efforts, as no specific antivirals or vaccines currently exist to treat or prevent norovirus gastroenteritis.

Published
2021

17. Broad betacoronavirus neutralization by a stem helix–specific human antibody

Author

Pinto, D, Sauer, MM, Czudnochowski, N, Low, JS, Alejandra Tortorici, M, Housley, MP, Noack, J, Walls, AC, Bowen, JE, Guarino, B, Rosen, LE, di Iulio, J, Jerak, J, Kaiser, H, Islam, S, Jaconi, S, Sprugasci, N, Culap, K, Abdelnabi, R, Foo, C, Coelmont, L, Bartha, I, Bianchi, S, Silacci-Fregni, C, Bassi, J, Marzi, R, Vetti, E, Cassotta, A, Ceschi, A, Ferrari, P, Cippà, PE, Giannini, O, Ceruti, S, Garzoni, C, Riva, A, Benigni, F, Cameroni, E, Piccoli, L, Pizzuto, MS, Smithey, M, Hong, D, Telenti, A, Lempp, FA, Neyts, J, Havenar-Daughton, C, Lanzavecchia, A, Sallusto, F, Snell, G, Virgin, HW, Beltramello, M, Corti, D, Veesler, D, Pinto, D, Sauer, MM, Czudnochowski, N, Low, JS, Alejandra Tortorici, M, Housley, MP, Noack, J, Walls, AC, Bowen, JE, Guarino, B, Rosen, LE, di Iulio, J, Jerak, J, Kaiser, H, Islam, S, Jaconi, S, Sprugasci, N, Culap, K, Abdelnabi, R, Foo, C, Coelmont, L, Bartha, I, Bianchi, S, Silacci-Fregni, C, Bassi, J, Marzi, R, Vetti, E, Cassotta, A, Ceschi, A, Ferrari, P, Cippà, PE, Giannini, O, Ceruti, S, Garzoni, C, Riva, A, Benigni, F, Cameroni, E, Piccoli, L, Pizzuto, MS, Smithey, M, Hong, D, Telenti, A, Lempp, FA, Neyts, J, Havenar-Daughton, C, Lanzavecchia, A, Sallusto, F, Snell, G, Virgin, HW, Beltramello, M, Corti, D, and Veesler, D

Abstract

The spillovers of betacoronaviruses in humans and the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad coronavirus countermeasures. We describe five monoclonal antibodies (mAbs) cross-reacting with the stem helix of multiple betacoronavirus spike glycoproteins isolated from COVID-19 convalescent individuals. Using structural and functional studies, we show that the mAb with the greatest breadth (S2P6) neutralizes pseudotyped viruses from three different subgenera through the inhibition of membrane fusion, and we delineate the molecular basis for its cross-reactivity. S2P6 reduces viral burden in hamsters challenged with SARS-CoV-2 through viral neutralization and Fc-mediated effector functions. Stem helix antibodies are rare, oftentimes of narrow specificity, and can acquire neutralization breadth through somatic mutations. These data provide a framework for structure-guided design of pan-betacoronavirus vaccines eliciting broad protection.

Published
2021

18. Multivalent Tryptophan- and Tyrosine-Containing [60]Fullerene Hexa-Adducts as Dual HIV and Enterovirus A71 Entry Inhibitors

Author

Ruiz-Santaquiteria M., Illescas B.M., Abdelnabi R., Boonen A., Mills A., Martí-Marí O., Noppen S., Neyts J., Schols D., Gago F., San-Félix A., Camarasa M.-J., Martín, Nazario, Ruiz-Santaquiteria M., Illescas B.M., Abdelnabi R., Boonen A., Mills A., Martí-Marí O., Noppen S., Neyts J., Schols D., Gago F., San-Félix A., Camarasa M.-J., and Martín, Nazario

Published
2021

19. A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

Author

Sanchez-Felipe, L, Vercruysse, T, Sharma, S, Ma, J, Lemmens, V, Van Looveren, D, Arkalagud Javarappa, MP, Boudewijns, R, Malengier-Devlies, B, Liesenborghs, L, Kaptein, SJF, De Keyzer, C, Bervoets, L, Debaveye, S, Rasulova, M, Seldeslachts, L, Li, LH, Jansen, S, Yakass, MB, Verstrepen, BE, Böszörményi, KP, Kiemenyi-Kayere, G, van Driel, N, Quaye, O, Zhang, X, Horst, S, Mishra, N, Deboutte, W, Matthijnssens, J, Coelmont, L, Vandermeulen, C, Heylen, E, Vergote, V, Schols, D, Wang, Zhongde, Bogers, W, Kuiken, Thijs, Verschoor, E, Cawthorne, C, Van Laere, K, Opdenakker, G, Velde, G, Weynand, B, Teuwen, DE, Matthys, P, Neyts, J, Jan Thibaut, H, Dallmeier, K, Sanchez-Felipe, L, Vercruysse, T, Sharma, S, Ma, J, Lemmens, V, Van Looveren, D, Arkalagud Javarappa, MP, Boudewijns, R, Malengier-Devlies, B, Liesenborghs, L, Kaptein, SJF, De Keyzer, C, Bervoets, L, Debaveye, S, Rasulova, M, Seldeslachts, L, Li, LH, Jansen, S, Yakass, MB, Verstrepen, BE, Böszörményi, KP, Kiemenyi-Kayere, G, van Driel, N, Quaye, O, Zhang, X, Horst, S, Mishra, N, Deboutte, W, Matthijnssens, J, Coelmont, L, Vandermeulen, C, Heylen, E, Vergote, V, Schols, D, Wang, Zhongde, Bogers, W, Kuiken, Thijs, Verschoor, E, Cawthorne, C, Van Laere, K, Opdenakker, G, Velde, G, Weynand, B, Teuwen, DE, Matthys, P, Neyts, J, Jan Thibaut, H, and Dallmeier, K

Abstract

The expanding pandemic of coronavirus disease 2019 (COVID-19) requires the development of safe, efficacious and fast-acting vaccines. Several vaccine platforms are being leveraged for a rapid emergency response1. Here we describe the development of a candidate vaccine (YF-S0) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that uses live-attenuated yellow fever 17D (YF17D) vaccine as a vector to express a noncleavable prefusion form of the SARS-CoV-2 spike antigen. We assess vaccine safety, immunogenicity and efficacy in several animal models. YF-S0 has an excellent safety profile and induces high levels of SARS-CoV-2 neutralizing antibodies in hamsters (Mesocricetus auratus), mice (Mus musculus) and cynomolgus macaques (Macaca fascicularis), and—concomitantly—protective immunity against yellow fever virus. Humoral immunity is complemented by a cellular immune response with favourable T helper 1 polarization, as profiled in mice. In a hamster model2 and in macaques, YF-S0 prevents infection with SARS-CoV-2. Moreover, a single dose conferred protection from lung disease in most of the vaccinated hamsters within as little as 10 days. Taken together, the quality of the immune responses triggered and the rapid kinetics by which protective immunity can be attained after a single dose warrant further development of this potent SARS-CoV-2 vaccine candidate.

Published
2021

21. The VIZIER project: Preparedness against pathogenic RNA viruses

Author

Coutard, B., Gorbalenya, A.E., Snijder, E.J., Leontovich, A.M., Poupon, A., De Lamballerie, X., Charrel, R., Gould, E.A., Gunther, S., Norder, H., Klempa, B., Bourhy, H., Rohayem, J., L’hermite, E., Nordlund, P., Stuart, D.I., Owens, R.J., Grimes, J.M., Tucker, P.A., Bolognesi, M., Mattevi, A., Coll, M., Jones, T.A., Åqvist, J., Unge, T., Hilgenfeld, R., Bricogne, G., Neyts, J., La Colla, P., Puerstinger, G., Gonzalez, J.P., Leroy, E., Cambillau, C., Romette, J.L., and Canard, B.

Published
2008
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22. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 5: Entomological aspects

Author

Pezzi, L., Diallo, M., Rosa-Freitas, M. G., Vega-Rua, A., Ng, L. F. P., Boyer, S., Drexler, J. F., Vasilakis, N., Lourenco-de-Oliveira, R., Weaver, S. C., Kohl, A., de Lamballerie, X., Failloux, A-B, Brasil, P., Busch, M., Diamond, M. S., Drebot, M. A., Gallian, P., Jaenisch, T., LaBeaud, A. D., Lecui, M., Neyts, J., Reusken, C. B., Ribeiro, G. S., Rios, M., Rodriguez-Morales, A. J., Sall, A., Simmons, G., Simon, F., Siqueira, A. M., Pezzi, L., Diallo, M., Rosa-Freitas, M. G., Vega-Rua, A., Ng, L. F. P., Boyer, S., Drexler, J. F., Vasilakis, N., Lourenco-de-Oliveira, R., Weaver, S. C., Kohl, A., de Lamballerie, X., Failloux, A-B, Brasil, P., Busch, M., Diamond, M. S., Drebot, M. A., Gallian, P., Jaenisch, T., LaBeaud, A. D., Lecui, M., Neyts, J., Reusken, C. B., Ribeiro, G. S., Rios, M., Rodriguez-Morales, A. J., Sall, A., Simmons, G., Simon, F., and Siqueira, A. M.

Abstract

The GloPID-R (Global Research Collaboration for Infectious Disease Preparedness) chikungunya (CHIKV), o'nyong-nyong (ONNV) and Mayaro virus (MAYV) Working Group has been established to investigate natural history, epidemiology and clinical aspects of infection by these viruses. Here, we present a report dedicated to entomological aspects of CHIKV, ONNV and MAYV. Recent global expansion of chikungunya virus has been possible because CHIKV established a transmission cycle in urban settings using anthropophilic vectors such as Aedes albopictus and Aedes aegypti. MAYV and ONNV have a more limited geographic distribution, being confined to Africa (ONNV) and central-southern America (MAYV). ONNV is probably maintained through an enzootic cycle that has not been characterized yet, with Anopheles species as main vectors and humans as amplification hosts during epidemics. MAYV is transmitted by Haemagogus species in an enzootic cycle using non-human primates as the main amplification and maintenance hosts, and humans becoming sporadically infected when venturing in or nearby forest habitats. Here, we focused on the transmission cycle and natural vectors that sustain circulation of these viruses in their respective locations. The knowledge of the natural ecology of transmission and the capacity of different vectors to transmit these viruses is crucial to understand CHIKV emergence, and to assess the risk that MAYV and ONNV will expand on wide scale using anthropophilic mosquito species not normally considered primary vectors. Finally, the experts identified knowledge gaps and provided adapted recommendations, in order to address future entomological investigations in the right direction.

Published
2020

23. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 5: Entomological aspects

Author

Pezzi, L. (L.), Diallo, M. (M.), Rosa-Freitas, M.G. (M. G.), Vega-Rua, A. (A.), Ng, L.F.P. (L. F.P.), Boyer, S. (S.), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), Lourenco-de-Oliveira, R. (R.), Weaver, S.C. (S. C.), Kohl, A. (A.), de Lamballerie, X. (X.), Failloux, A.-B. (A. B.), Brasil, P. (P.), Busch, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Gallian, P. (P.), Jaenisch, T. (T.), LaBeaud, A.D. (A. D.), Lecuit, M. (M.), Neyts, J. (J.), Reusken, C.B.E.M. (Chantal), Ribeiro, G.S. (G. S.), Rios, M. (M.), Rodriguez-Morales, A.J. (A. J.), Sall, A. (A.), Simmons, G. (G.), Simon, F. (F.), Siqueira, A.M. (A. M.), Pezzi, L. (L.), Diallo, M. (M.), Rosa-Freitas, M.G. (M. G.), Vega-Rua, A. (A.), Ng, L.F.P. (L. F.P.), Boyer, S. (S.), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), Lourenco-de-Oliveira, R. (R.), Weaver, S.C. (S. C.), Kohl, A. (A.), de Lamballerie, X. (X.), Failloux, A.-B. (A. B.), Brasil, P. (P.), Busch, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Gallian, P. (P.), Jaenisch, T. (T.), LaBeaud, A.D. (A. D.), Lecuit, M. (M.), Neyts, J. (J.), Reusken, C.B.E.M. (Chantal), Ribeiro, G.S. (G. S.), Rios, M. (M.), Rodriguez-Morales, A.J. (A. J.), Sall, A. (A.), Simmons, G. (G.), Simon, F. (F.), and Siqueira, A.M. (A. M.)

Abstract

The GloPID-R (Global Research Collaboration for Infectious Disease Preparedness) chikungunya (CHIKV), o'nyong-nyong (ONNV) and Mayaro virus (MAYV) Working Group has been established to investigate natural history, epidemiology and clinical aspects of infection by these viruses. Here, we present a report dedicated to entomological aspects of CHIKV, ONNV and MAYV. Recent global expansion of chikungunya virus has been possible because CHIKV established a transmission cycle in urban settings using anthropophilic vectors such as Aedes albopictus and Aedes aegypti. MAYV and ONNV have a more limited geographic distribution, being confined to Africa (ONNV) and central-southern America (MAYV). ONNV is probably maintained through an enzootic cycle that has not been characterized yet, with Anopheles species as main vectors and humans as amplification hosts during epidemics. MAYV is transmitted by Haemagogus species in an enzootic cycle using non-human primates as the main amplification and maintenance hosts, and humans becoming sporadically infected when venturing

Published
2020
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24. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 5: Entomological aspects

Author

Pezzi, L, Diallo, M, Rosa-Freitas, MG, Vega-Rua, A, Ng, LFP, Boyer, S, Drexler, JF, Vasilakis, N, Lourenco-De-Oliveira, R, Weaver, SC, Kohl, A, de Lamballerie, X, Failloux, AB, Brasil, P, Busch, M, Diamond, MS, Drebot, MA, Gallian, P, Jaenisch, T, LaBeaud, AD, Lecuit, M, Neyts, J, Reusken, Chantal, Ribeiro, GS, del Rios, M, Rodriguez-Morales, AJ, Sall, A, Simmons, G, Simon, F, Siqueira, AM, Pezzi, L, Diallo, M, Rosa-Freitas, MG, Vega-Rua, A, Ng, LFP, Boyer, S, Drexler, JF, Vasilakis, N, Lourenco-De-Oliveira, R, Weaver, SC, Kohl, A, de Lamballerie, X, Failloux, AB, Brasil, P, Busch, M, Diamond, MS, Drebot, MA, Gallian, P, Jaenisch, T, LaBeaud, AD, Lecuit, M, Neyts, J, Reusken, Chantal, Ribeiro, GS, del Rios, M, Rodriguez-Morales, AJ, Sall, A, Simmons, G, Simon, F, and Siqueira, AM

Published
2020

29. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 5: Entomological aspects

Author

Pezzi, L., primary, Diallo, M., additional, Rosa-Freitas, M.G., additional, Vega-Rua, A., additional, Ng, L.F.P., additional, Boyer, S., additional, Drexler, J.F., additional, Vasilakis, N., additional, Lourenco-de-Oliveira, R., additional, Weaver, S.C., additional, Kohl, A., additional, de Lamballerie, X., additional, Failloux, A.-B., additional, Brasil, P., additional, Busch, M., additional, Diamond, M.S., additional, Drebot, M.A., additional, Gallian, P., additional, Jaenisch, T., additional, LaBeaud, A.D., additional, Lecuit, M., additional, Neyts, J., additional, Reusken, C.B., additional, Ribeiro, G.S., additional, Rios, M., additional, Rodriguez-Morales, A.J., additional, Sall, A., additional, Simmons, G., additional, Simon, F., additional, and Siqueira, A.M., additional

Published
2020
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30. Itraconazole for COVID-19: Preclinical Studies and a Proof-of-Concept Pilot Clinical Study

Author

Liesenborghs, Laurens, primary, Spriet, Isabel, additional, Jochmans, Dirk, additional, Belmans, Ann, additional, Gyselinck, Iwein, additional, Teuwen, Laure-Anne, additional, ter Horst, Sebastiaan, additional, Dreesen, E, additional, Geukens, Tatjana, additional, Engelen, Matthias, additional, Landeloos, Ewout, additional, Geldhof, Vincent, additional, Ceunen, Helga, additional, Debaveye, Barbara, additional, Vandenberk, Bert, additional, Van der Linden, Lorenz, additional, Jacobs, Sofie, additional, Langendries, Lana, additional, Boudewijns, Robbert, additional, Weynand, Birgit, additional, Vanassche, Thomas, additional, Devos, Timothy, additional, Meyfroidt, Geert, additional, Janssens, Wim, additional, Vos, Robin, additional, Vermeersch, Pieter, additional, Wauters, Joost, additional, Verbeke, Geert, additional, De Munter, Paul, additional, Kaptein, Suzanne J. F., additional, Rocha-Pereira, Joana Duarte, additional, Delang, Leen, additional, Van Wijngaerden, Eric, additional, Neyts, J, additional, and Verhamme, Peter, additional

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2020
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31. Monocyte-Driven Atypical Cytokine Storm and Aberrant Neutrophil Activation as Key Mediators of COVID19 Disease Severity

Author

Vanderbeke, Lore, primary, Van Mol, Pierre, additional, Van Herck, Y, additional, De Smet, F, additional, Humblet-Baron, S, additional, Martinod, K, additional, Antoranz, A, additional, Arijs, I, additional, Boeckx, B, additional, Bosisio, FM, additional, Casaer, M, additional, Dauwe, D, additional, De Wever, W, additional, Dooms, Christophe, additional, Dreesen, E, additional, Emmaneel, A, additional, Filtjens, J, additional, Gouwy, M, additional, Gunst, J, additional, Hermans, G, additional, Jansen, S, additional, Lagrou, K, additional, Liston, A, additional, Lorent, N, additional, Meersseman, P, additional, Mercier, T, additional, Neyts, J, additional, Odent, J, additional, Panovska, Dena, additional, Penttila, PA, additional, Pollet, E, additional, Proost, P, additional, Qian, J, additional, Quintelier, K, additional, Raes, J, additional, Rex, S, additional, Saeys, Yvan, additional, Sprooten, J, additional, Tejpar, S, additional, Testelmans, D, additional, Thevissen, K, additional, Van Buyten, T, additional, Vandenhaute, J, additional, Van Gassen, S, additional, Velásquez Pereira, LC, additional, Vos, R, additional, Weynand, B, additional, Wilmer, A, additional, Yserbyt, J, additional, Garg, Abhishek, additional, Matthys, P, additional, Wouters, C, additional, Lambrechts, D, additional, Wauters, Els, additional, and Wauters, J, additional

Published
2020
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32. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 2: Epidemiological distribution of o'nyong-nyong virus

Author

Pezzi, L., primary, LaBeaud, A.D., additional, Reusken, C.B., additional, Drexler, J.F., additional, Vasilakis, N., additional, Diallo, M., additional, Simon, F., additional, Jaenisch, T., additional, Gallian, P., additional, Sall, A., additional, Failloux, A.B., additional, Weaver, S.C., additional, de Lamballerie, X., additional, Boyer, S., additional, Brasil, P., additional, Busch, M., additional, Diamond, M.S., additional, Drebot, M.A., additional, Kohl, A., additional, Lecuit, M., additional, Lourenço-de-Oliveira, R., additional, Neyts, J., additional, Lfp, Ng, additional, Ribeiro, G.S., additional, Rios, M., additional, Rodriguez-Morales, A.J., additional, Rosa-Freitas, M.G., additional, Simmons, G., additional, Siqueira, A.M., additional, and Vega Rua, A., additional

Published
2019
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34. ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas

Author

Aliyeva, S, Wilder-Smith, A, Preet, R, Brickley, EB, de Alencar Ximenes, RA, de Barros Miranda-Filho, D, Martelli, CMT, de Araújo, TVB, Montarroyos, UR, Moreira, ME, Turchi, MD, Solomon, T, Jacobs, BC, Villamizar, CP, Osorio, L, de Filipps, AMB, Neyts, J, Kaptein, S, Huits, R, Ariën, KK, Willison, HJ, Edgar, JM, Barnett, SC, Peeling, R, Boeras, D, Guzman, MG, de Silva, AM, Falconar, AK, Romero-Vivas, C, Gaunt, MW, Sette, A, Weiskopf, D, Lambrechts, L, Dolk, H, Morris, JK, Orioli, LM, O'Reilly, KM, Yakob, L, Rocklöv, J, Soares, C, Ferreira, MLB, de Oliveira Franca, RF, Precioso, AR, Logan, J, Lang, T, Jamieson, N, Massad, E, Umeå University, London School of Hygiene and Tropical Medicine (LSHTM), Universidade Federal de Pernambuco [Recife] (UFPE), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), University of Liverpool, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Johns Hopkins University (JHU), Universidad del Valle, Colombia, Instituto Oswaldo Cruz / Oswaldo Cruz Institute [Rio de Janeiro] (IOC), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Rega Institute of Medical Research [Leuven, Belgium], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Institute of Tropical Medicine [Antwerp] (ITM), University of Glasgow, Pedro Kouri Institute of Tropical Medicine, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), La Jolla Institute for Immunology [La Jolla, CA, États-Unis], University of California [San Diego] (UC San Diego), University of California (UC), Interactions Virus-Insectes - Insect-Virus Interactions (IVI), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), University of Ulster, University of London [London], Universidade Federal do Rio de Janeiro (UFRJ), Instituto Butantan [São Paulo], University of Oxford, Universidade de São Paulo = University of São Paulo (USP), Fundacao Getulio Vargas [Rio de Janeiro] (FGV), Immunology, and Neurology

Subjects
congenital Zika syndrome, Mosquito Control, Knowledge management, Latin Americans, OUTBREAK, zika, encephalitis, [SDV]Life Sciences [q-bio], Health Services Accessibility, Disease Outbreaks, 0302 clinical medicine, Open research, epidemic preparedness, Pregnancy, HISTORY, EPIDEMIOLOGY, European commission, 030212 general & internal medicine, microcephaly, Public, Environmental & Occupational Health, Zika Virus Infection, 030503 health policy & services, Health Policy, lcsh:Public aspects of medicine, Public Health, Global Health, Social Medicine and Epidemiology, BRAZIL, Guillain-Barré syndrome, sustainability, TRAVELERS, 3. Good health, Research objectives, GUILLAIN-BARRE-SYNDROME, Population Surveillance, Preparedness, Female, 0305 other medical science, Life Sciences & Biomedicine, Brazil, congenital zika syndrome, Capacity Building, Clinical cohort, TRANSMISSION, birth defect, VIRUS-INFECTION, research capacity building, DIAGNOSIS, Guillain-Barr? syndrome, Congenital Abnormalities, 03 medical and health sciences, Zika, Research capacity, Political science, SURVEILLANCE, Humans, european commission, guillain-barré syndrome, European Commission, Science & Technology, business.industry, Infant, Newborn, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Zika Virus, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Sustainability, Americas, business
Abstract

Zika Preparedness Latin American Network (ZikaPLAN) is a research consortium funded by the European Commission to address the research gaps in combating Zika and to establish a sustainable network with research capacity building in the Americas. Here we present a report on ZikaPLAN`s mid-term achievements since its initiation in October 2016 to June 2019, illustrating the research objectives of the 15 work packages ranging from virology, diagnostics, entomology and vector control, modelling to clinical cohort studies in pregnant women and neonates, as well as studies on the neurological complications of Zika infections in adolescents and adults. For example, the Neuroviruses Emerging in the Americas Study (NEAS) has set up more than 10 clinical sites in Colombia. Through the Butantan Phase 3 dengue vaccine trial, we have access to samples of 17,000 subjects in 14 different geographic locations in Brazil. To address the lack of access to clinical samples for diagnostic evaluation, ZikaPLAN set up a network of quality sites with access to well-characterized clinical specimens and capacity for independent evaluations. The International Committee for Congenital Anomaly Surveillance Tools was formed with global representation from regional networks conducting birth defects surveillance. We have collated a comprehensive inventory of resources and tools for birth defects surveillance, and developed an App for low resource regions facilitating the coding and description of all major externally visible congenital anomalies including congenital Zika syndrome. Research Capacity Network (REDe) is a shared and open resource centre where researchers and health workers can access tools, resources and support, enabling better and more research in the region. Addressing the gap in research capacity in LMICs is pivotal in ensuring broad-based systems to be prepared for the next outbreak. Our shared and open research space through REDe will be used to maximize the transfer of research into practice by summarizing the research output and by hosting the tools, resources, guidance and recommendations generated by these studies. Leveraging on the research from this consortium, we are working towards a research preparedness network. ispartof: GLOBAL HEALTH ACTION vol:12 issue:1 ispartof: location:United States status: published

Published
2019

35. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 3: Epidemiological distribution of Mayaro virus

Author

Pezzi, L., Rodriguez-Morales, A.J., Reusken, C.B., Ribeiro, G.S., Labeaud, A.D., Lourenço-De-Oliveira, R., Brasil, P., Lecuit, M., Failloux, Anna-Bella, Gallian, P., Jaenisch, T., Simon, F., Siqueira, A.M., Rosa-Freitas, M.G., Vega Rua, A., Weaver, S.C., Drexler, J.F., Vasilakis, N., de Lamballerie, Xavier, Boyer, Sébastien, Busch, M., Diallo, M., Diamond, M.S., Drebot, M.A., Kohl, A., Neyts, J., Ng, L.F.P., Rios, M., Sall, A., Simmons, G., Virology, Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Virologie [UNIV Corse-Inserm] (EA7310), Université Pascal Paoli (UPP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidad Tecnológica de Pereira [Colombie] (UTP), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Universidade Federal da Bahia (UFBA), Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), Biologie des Infections - Biology of Infection, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Arbovirus et Insectes Vecteurs - Arboviruses and Insect Vectors, Institut Pasteur [Paris] (IP), Etablissement Français du Sang - Alpes-Méditerranée (EFS - Alpes-Méditerranée), Etablissement Français du Sang, Heidelberg University Hospital [Heidelberg], Hôpital d'Instruction des Armées Laveran, Service de Santé des Armées, Institut Pasteur de la Guadeloupe, The University of Texas Medical Branch (UTMB), German Center for Infection Research - partner site Hannover-Braunschweig (DZIF), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Humboldt University Of Berlin, Berlin Institute of Health (BIH), Institut Pasteur du Cambodge, University of California [San Francisco] (UC San Francisco), University of California (UC), Institut Pasteur de Dakar, Washington University in Saint Louis (WUSTL), Public Health Agency of Canada, MRC - University of Glasgow Centre for Virus Research, Laboratory of Virology and Chemotherapy [KU Leuven], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven)-Rega Institute of Medical Research [Leuven, Belgium], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Agency for science, technology and research [Singapore] (A*STAR), U.S. Food and Drug Administration (FDA), Publication fees were covered by the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R)., DEMESLAY GOUGAM, MARIE, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pascal Paoli (UPP), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Institut Pasteur [Paris], Humboldt-Universität zu Berlin, University of California [San Francisco] (UCSF), University of California, and Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ)

Subjects
Primates, GloPID-R chikungunya, o'nyong-nyong and Mayaro virus Working Group, 030231 tropical medicine, Alphavirus, Genome, Viral, Mosquito Vectors, Disease Outbreaks, 03 medical and health sciences, 0302 clinical medicine, Seroepidemiologic Studies, Virology, Zoonoses, Animals, Humans, O'nyong-nyong Virus, Serologic Tests, 030212 general & internal medicine, Pathology, Molecular, ComputingMilieux_MISCELLANEOUS, Phylogeny, Disease Reservoirs, Pharmacology, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Alphavirus Infections, 3. Good health, Caribbean Region, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Chikungunya Fever, Americas, Chikungunya virus
Abstract

ispartof: ANTIVIRAL RESEARCH vol:172 ispartof: location:Netherlands status: published

Published
2019

40. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 3: Epidemiological distribution of Mayaro virus

Author

Pezzi, L. (L.), Rodriguez-Morales, A.J. (A. J.), Reusken, C.B.E.M. (Chantal), Ribeiro, G.S. (G. S.), LaBeaud, A.D. (A. D.), Lourenço-de-Oliveira, R. (R.), Brasil, P. (P.), Lecuit, M. (M.), Failloux, A.B. (A. B.), Gallian, P. (P.), Jaenisch, T. (T.), Simon, F. (F.), Siqueira, A.M. (A. M.), Rosa-Freitas, M.G. (M. G.), Vega Rua, A. (A.), Weaver, S.C. (S. C.), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), de Lamballerie X, (), Boyer, S. (S.), Busch, M. (M.), Diallo, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Kohl, A. (A.), Neyts, J. (J.), Ng, L.F.P. (L. F.P.), Rios, M. (M.), Sall, A. (A.), Simmons, G. (G.), Pezzi, L. (L.), Rodriguez-Morales, A.J. (A. J.), Reusken, C.B.E.M. (Chantal), Ribeiro, G.S. (G. S.), LaBeaud, A.D. (A. D.), Lourenço-de-Oliveira, R. (R.), Brasil, P. (P.), Lecuit, M. (M.), Failloux, A.B. (A. B.), Gallian, P. (P.), Jaenisch, T. (T.), Simon, F. (F.), Siqueira, A.M. (A. M.), Rosa-Freitas, M.G. (M. G.), Vega Rua, A. (A.), Weaver, S.C. (S. C.), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), de Lamballerie X, (), Boyer, S. (S.), Busch, M. (M.), Diallo, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Kohl, A. (A.), Neyts, J. (J.), Ng, L.F.P. (L. F.P.), Rios, M. (M.), Sall, A. (A.), and Simmons, G. (G.)

Published
2019
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41. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 2: Epidemiological distribution of o'nyong-nyong virus

Author

Pezzi, L. (L.), LaBeaud, A.D. (A. D.), Reusken, C.B.E.M. (Chantal), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), Diallo, M. (M.), Simon, F. (F.), Jaenisch, T. (T.), Gallian, P. (P.), Sall, A. (A.), Failloux, A.B. (A. B.), Weaver, S.C. (S. C.), de Lamballerie, X. (Xavier), Boyer, S. (S.), Brasil, P. (P.), Busch, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Kohl, A. (A.), Lecuit, M. (M.), Lourenço-de-Oliveira, R. (R.), Neyts, J. (J.), Lfp, N. (Ng), Ribeiro, G.S. (G. S.), Rios, M. (M.), Rodriguez-Morales, A.J. (A. J.), Rosa-Freitas, M.G. (M. G.), Simmons, G. (G.), Siqueira, A.M. (A. M.), Vega Rua, A. (A.), Pezzi, L. (L.), LaBeaud, A.D. (A. D.), Reusken, C.B.E.M. (Chantal), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), Diallo, M. (M.), Simon, F. (F.), Jaenisch, T. (T.), Gallian, P. (P.), Sall, A. (A.), Failloux, A.B. (A. B.), Weaver, S.C. (S. C.), de Lamballerie, X. (Xavier), Boyer, S. (S.), Brasil, P. (P.), Busch, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Kohl, A. (A.), Lecuit, M. (M.), Lourenço-de-Oliveira, R. (R.), Neyts, J. (J.), Lfp, N. (Ng), Ribeiro, G.S. (G. S.), Rios, M. (M.), Rodriguez-Morales, A.J. (A. J.), Rosa-Freitas, M.G. (M. G.), Simmons, G. (G.), Siqueira, A.M. (A. M.), and Vega Rua, A. (A.)

Abstract

The GloPID-R (Global Research Collaboration for Infectious Disease Preparedness) chikungunya (CHIKV), o'nyong-nyong (ONNV) and Mayaro virus (MAYV) Working Group has been established to identify gaps of knowledge about the natural history, epidemiology and medical management of infection by these viruses, and to provide adapted recommendations for future investigations. Here, we present a report dedicated to ONNV epidemiological distribution. Two large-scale ONNV outbreaks have been identified in Africa in the last 60 years, interspersed with sporadic serosurveys and case reports of returning travelers. The assessment of the real scale of ONNV circulation in Africa remains a difficult task and surveillance studies are necessary to fill this gap. The identification of ONNV etiology is made complicated by the absence of multiplex tools in co-circulatio

Published
2019
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42. ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas

Author

Wilder-Smith, A. (Annelies), Preet, R. (Raman), Brickley, E.B. (Elizabeth B.), Ximenes, R.A.A. (Ricardo Arraes de Alencar), Miranda-Filho, D.B. (Demócrito de Barros), Turchi Martelli, C.M. (Celina Maria), Araújo, T.V.B. (Thália Velho Barreto de), Montarroyos, U.R. (Ulisses Ramos), Moreira, M.E. (Maria Elisabeth), Turchi, M.D. (Marília Dalva), Solomon, T. (Tom), Jacobs, B.C. (Bart), Villamizar, C.P. (Carlos Pardo), Osorio, L. (Lyda), de Filipps, A.M.B. (Ana Maria Bispo), Neyts, J., Kaptein, S.J.F. (Suzanne), Huits, R.M.H.G. (Ralph M. H. G.), Ariën, K.K. (Kevin K.), Willison, H.J. (Hugh), Edgar, J. (Julia), Barnett, S.C. (Susan C.), Peeling, R. (Rosanna), Boeras, D. (Debi), Guzman, M.G. (Maria G.), de Silva, A.M. (Aravinda M.), Falconar, A., Romero-Vivas, C. (Claudia), Gaunt, M.W. (Michael W.), Sette, A. (Alessandro), Weiskopf, D. (Daniela), Lambrechts, L. (Louis), Dolk, H. (Helen), Morris, J.K. (Joan K.), Orioli, I.M. (Ieda M.), O'Reilly, K.M. (Kathleen M.), Yakob, L. (Laith), Rocklöv, J. (Joacim), Soares, C. (Cristiane), Ferreira, M.L.B. (Maria Lúcia Brito), Franca, R.F.O. (Rafael Freitas de Oliveira), Precioso, A.R. (Alexander R.), Logan, J. (James), Lang, T. (Trudie), Jamieson, N. (Nina), Massad, E. (Eduardo), Wilder-Smith, A. (Annelies), Preet, R. (Raman), Brickley, E.B. (Elizabeth B.), Ximenes, R.A.A. (Ricardo Arraes de Alencar), Miranda-Filho, D.B. (Demócrito de Barros), Turchi Martelli, C.M. (Celina Maria), Araújo, T.V.B. (Thália Velho Barreto de), Montarroyos, U.R. (Ulisses Ramos), Moreira, M.E. (Maria Elisabeth), Turchi, M.D. (Marília Dalva), Solomon, T. (Tom), Jacobs, B.C. (Bart), Villamizar, C.P. (Carlos Pardo), Osorio, L. (Lyda), de Filipps, A.M.B. (Ana Maria Bispo), Neyts, J., Kaptein, S.J.F. (Suzanne), Huits, R.M.H.G. (Ralph M. H. G.), Ariën, K.K. (Kevin K.), Willison, H.J. (Hugh), Edgar, J. (Julia), Barnett, S.C. (Susan C.), Peeling, R. (Rosanna), Boeras, D. (Debi), Guzman, M.G. (Maria G.), de Silva, A.M. (Aravinda M.), Falconar, A., Romero-Vivas, C. (Claudia), Gaunt, M.W. (Michael W.), Sette, A. (Alessandro), Weiskopf, D. (Daniela), Lambrechts, L. (Louis), Dolk, H. (Helen), Morris, J.K. (Joan K.), Orioli, I.M. (Ieda M.), O'Reilly, K.M. (Kathleen M.), Yakob, L. (Laith), Rocklöv, J. (Joacim), Soares, C. (Cristiane), Ferreira, M.L.B. (Maria Lúcia Brito), Franca, R.F.O. (Rafael Freitas de Oliveira), Precioso, A.R. (Alexander R.), Logan, J. (James), Lang, T. (Trudie), Jamieson, N. (Nina), and Massad, E. (Eduardo)

Abstract

Zika Preparedness Latin American Network (ZikaPLAN) is a research consortium funded by the European Commission to address the research gaps in combating Zika and to establish a sustainable network with research capacity building in the Americas. Here we present a report on ZikaPLAN`s mid-term achievements since its initiation in October 2016 to June 2019, illustrating the research objectives of the 15 work packages ranging from virology, diagnostics, entomology and vector control, modelling to clinical cohort studies in pregnant women and neonates, as well as studies on the neurological complications of Zika infections in adolescents and adults. For example, the Neuroviruses Emerging in the Americas Study (NEAS) has set up more than 10 clinical sites in Colombia. Through the Butantan Phase 3 dengue vaccine trial, we have access to samples of 17,000 subjects in 14 different geographic locations in Brazil. To address the lack of access to clinical samples for diagnostic evaluation, ZikaPLAN set up a network of quality sites with access to well-characterized clinical specimens and capacity for independent evaluations. The International Committee for Congenital Anomaly Surveillance Tools was formed with global representation from regional networks conducting birth defects surveillance. We have collated a comprehensive inventory of resources and tools for birth defects surveillance, and developed an App for low resource regions facilitating the coding and description of all major externally visible congenital anomalies including congenital Zika syndrome. Research Capacity Network (REDe) is a shared and open resource centre where researchers and health workers can access tools, resources and support, enabling better and more research in the region. Addressing the gap in research capacity in LMICs is pivotal in ensuring broad-based systems to be prepared for the next outbreak. Our shared and open research space through REDe will be used to maximize the transfer of research

Published
2019
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43. GloPID-R report on Chikungunya, O'nyong-nyong and Mayaro virus, part I: Biological diagnostics

Author

Pezzi, L., Reusken, C.B.E.M. (Chantal), Weaver, S.C., Drexler, JF, Busch, M., LaBeaud, A.D., Diamond, M.S., Vasilakis, N, Drebot, M.A., Siqueira, A.M., Ribeiro, G.S., Kohl, A., Lecuit, M., Ng, L.F.P., Gallian, P., de Lamballerie, X, Boyer, S. (Scott), Brasil, P., Diallo, M., Failloux, A.B., Jaenisch, T., Lourenco-De-Oliveira, R., Neyts, J., del Rios, M., Rodriguez-Morales, A.J., Rosa-Freitas, M.G., Sall, A., Simmons, G., Simon, F., Rua, A.V., Glo, P.I.D.R.C.O.n.-n., Pezzi, L., Reusken, C.B.E.M. (Chantal), Weaver, S.C., Drexler, JF, Busch, M., LaBeaud, A.D., Diamond, M.S., Vasilakis, N, Drebot, M.A., Siqueira, A.M., Ribeiro, G.S., Kohl, A., Lecuit, M., Ng, L.F.P., Gallian, P., de Lamballerie, X, Boyer, S. (Scott), Brasil, P., Diallo, M., Failloux, A.B., Jaenisch, T., Lourenco-De-Oliveira, R., Neyts, J., del Rios, M., Rodriguez-Morales, A.J., Rosa-Freitas, M.G., Sall, A., Simmons, G., Simon, F., Rua, A.V., and Glo, P.I.D.R.C.O.n.-n.

Abstract

The GloPID-R (Global Research Collaboration for Infectious Disease Preparedness) Chikungunya (CHIKV), O'nyong-nyong (ONNV) and Mayaro virus (MAYV) Working Group is investigating

Published
2019
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44. Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines.

Author

Hernandez, N, Bucciol, G, Moens, L, Le Pen, J, Shahrooei, M, Goudouris, E, Shirkani, A, Changi-Ashtiani, M, Rokni-Zadeh, H, Sayar, EH, Reisli, I, Lefevre-Utile, A, Zijlmans, D, Jurado, A, Pholien, R, Drutman, S, Belkaya, S, Cobat, A, Boudewijns, R, Jochmans, D, Neyts, J, Seeleuthner, Y, Lorenzo-Diaz, L, Enemchukwu, C, Tietjen, I, Hoffmann, H-H, Momenilandi, M, Pöyhönen, L, Siqueira, MM, de Lima, SMB, de Souza Matos, DC, Homma, A, Maia, MDLS, da Costa Barros, TA, de Oliveira, PMN, Mesquita, EC, Gijsbers, R, Zhang, S-Y, Seligman, SJ, Abel, L, Hertzog, P, Marr, N, Martins, RDM, Meyts, I, Zhang, Q, MacDonald, MR, Rice, CM, Casanova, J-L, Jouanguy, E, Bossuyt, X, Hernandez, N, Bucciol, G, Moens, L, Le Pen, J, Shahrooei, M, Goudouris, E, Shirkani, A, Changi-Ashtiani, M, Rokni-Zadeh, H, Sayar, EH, Reisli, I, Lefevre-Utile, A, Zijlmans, D, Jurado, A, Pholien, R, Drutman, S, Belkaya, S, Cobat, A, Boudewijns, R, Jochmans, D, Neyts, J, Seeleuthner, Y, Lorenzo-Diaz, L, Enemchukwu, C, Tietjen, I, Hoffmann, H-H, Momenilandi, M, Pöyhönen, L, Siqueira, MM, de Lima, SMB, de Souza Matos, DC, Homma, A, Maia, MDLS, da Costa Barros, TA, de Oliveira, PMN, Mesquita, EC, Gijsbers, R, Zhang, S-Y, Seligman, SJ, Abel, L, Hertzog, P, Marr, N, Martins, RDM, Meyts, I, Zhang, Q, MacDonald, MR, Rice, CM, Casanova, J-L, Jouanguy, E, and Bossuyt, X

Abstract

Vaccination against measles, mumps, and rubella (MMR) and yellow fever (YF) with live attenuated viruses can rarely cause life-threatening disease. Severe illness by MMR vaccines can be caused by inborn errors of type I and/or III interferon (IFN) immunity (mutations in IFNAR2, STAT1, or STAT2). Adverse reactions to the YF vaccine have remained unexplained. We report two otherwise healthy patients, a 9-yr-old boy in Iran with severe measles vaccine disease at 1 yr and a 14-yr-old girl in Brazil with viscerotropic disease caused by the YF vaccine at 12 yr. The Iranian patient is homozygous and the Brazilian patient compound heterozygous for loss-of-function IFNAR1 variations. Patient-derived fibroblasts are susceptible to viruses, including the YF and measles virus vaccine strains, in the absence or presence of exogenous type I IFN. The patients' fibroblast phenotypes are rescued with WT IFNAR1 Autosomal recessive, complete IFNAR1 deficiency can result in life-threatening complications of vaccination with live attenuated measles and YF viruses in previously healthy individuals.

Published
2019

45. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 3: Epidemiological distribution of Mayaro virus

Author

Pezzi, L, Rodriguez-Morales, AJ, Reusken, Chantal, Ribeiro, GS, LaBeaud, AD, Lourenco-De-Oliveira, R, Brasil, P, Lecuit, M, Failloux, AB, Gallian, P, Jaenisch, T, Simon, F, Siqueira, AM, Rosa-Freitas, MG, Rua, AV, Weaver, SC, Drexler, JF, Vasilakis, N, de Lamballerie, X, Boyer, S, Busch, M, Diallo, M, Diamond, MS, Drebot, MA, Kohl, A, Neyts, J, Ng, LFP, del Rios, M, Sall, A, Simmons, G, Pezzi, L, Rodriguez-Morales, AJ, Reusken, Chantal, Ribeiro, GS, LaBeaud, AD, Lourenco-De-Oliveira, R, Brasil, P, Lecuit, M, Failloux, AB, Gallian, P, Jaenisch, T, Simon, F, Siqueira, AM, Rosa-Freitas, MG, Rua, AV, Weaver, SC, Drexler, JF, Vasilakis, N, de Lamballerie, X, Boyer, S, Busch, M, Diallo, M, Diamond, MS, Drebot, MA, Kohl, A, Neyts, J, Ng, LFP, del Rios, M, Sall, A, and Simmons, G

Published
2019

46. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 2: Epidemiological distribution of o'nyong-nyong virus

Author

Pezzi, L, LaBeaud, AD, Reusken, Chantal, Drexler, JF, Vasilakis, N, Diallo, M, Simon, F, Jaenisch, T, Gallian, P, Sall, A, Failloux, AB, Weaver, SC, de Lamballerie, X, Boyer, S, Brasil, P, Busch, M, Diamond, MS, Drebot, MA, Kohl, A, Lecuit, M, Lourenco-De-Oliveira, R, Neyts, J, Lfp, N, Ribeiro, GS, del Rios, M, Rodriguez-Morales, AJ, Rosa-Freitas, MG, Simmons, G, Siqueira, AM, Rua, AV, Pezzi, L, LaBeaud, AD, Reusken, Chantal, Drexler, JF, Vasilakis, N, Diallo, M, Simon, F, Jaenisch, T, Gallian, P, Sall, A, Failloux, AB, Weaver, SC, de Lamballerie, X, Boyer, S, Brasil, P, Busch, M, Diamond, MS, Drebot, MA, Kohl, A, Lecuit, M, Lourenco-De-Oliveira, R, Neyts, J, Lfp, N, Ribeiro, GS, del Rios, M, Rodriguez-Morales, AJ, Rosa-Freitas, MG, Simmons, G, Siqueira, AM, and Rua, AV

Published
2019

47. ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas

Author

Wilder-Smith, A, Preet, R, Brickley, EB, Ximenes, RAD, Miranda, DDR, Martelli, CMT, de Araujo, TVB, Montarroyos, UR, Moreira, ME, Turchi, MD, Solomon, T, Jacobs, B.C., Villamizar, CP, Osorio, L, de Filipps, AMB, Neyts, J, Kaptein, S, Huits, R, Arien, KK, Willison, HJ, Edgar, JM, Barnett, SC, Peeling, R, Boeras, D, Guzman, MG, Silva, AM, Falconar, AK, Romero-Vivas, C, Gaunt, MW, Sette, A, Weiskopf, D, Lambrechts, L, Dolk, H, Morris, J K, Orioli, IM, O'Reilly, KM, Yakob, L, Rocklov, J, Soares, C, Ferreira, MLB, Franca, RFD, Precioso, AR, Logan, J, Lang, T, Jamieson, N, Massad, E, Wilder-Smith, A, Preet, R, Brickley, EB, Ximenes, RAD, Miranda, DDR, Martelli, CMT, de Araujo, TVB, Montarroyos, UR, Moreira, ME, Turchi, MD, Solomon, T, Jacobs, B.C., Villamizar, CP, Osorio, L, de Filipps, AMB, Neyts, J, Kaptein, S, Huits, R, Arien, KK, Willison, HJ, Edgar, JM, Barnett, SC, Peeling, R, Boeras, D, Guzman, MG, Silva, AM, Falconar, AK, Romero-Vivas, C, Gaunt, MW, Sette, A, Weiskopf, D, Lambrechts, L, Dolk, H, Morris, J K, Orioli, IM, O'Reilly, KM, Yakob, L, Rocklov, J, Soares, C, Ferreira, MLB, Franca, RFD, Precioso, AR, Logan, J, Lang, T, Jamieson, N, and Massad, E

Published
2019

48. GloPID-R report on Chikungunya, O'nyong-nyong and Mayaro virus, part I: Biological diagnostics

Author

Pezzi, L, Reusken, Chantal, Weaver, SC, Drexler, JF, Busch, M, LaBeaud, AD, Diamond, MS, Vasilakis, N, Drebot, MA, Siqueira, AM, Ribeiro, GS, Kohl, A, Lecuit, M, Ng, LFP, Gallian, P, de Lamballerie, X, Boyer, S, Brasil, P, Diallo, M, Failloux, AB, Jaenisch, T, Lourenco-De-Oliveira, R, Neyts, J, del Rios, M, Rodriguez-Morales, AJ, Rosa-Freitas, MG, Sall, A, Simmons, G, Simon, F, Rua, AV, Glo, PIDRCOn-n, Pezzi, L, Reusken, Chantal, Weaver, SC, Drexler, JF, Busch, M, LaBeaud, AD, Diamond, MS, Vasilakis, N, Drebot, MA, Siqueira, AM, Ribeiro, GS, Kohl, A, Lecuit, M, Ng, LFP, Gallian, P, de Lamballerie, X, Boyer, S, Brasil, P, Diallo, M, Failloux, AB, Jaenisch, T, Lourenco-De-Oliveira, R, Neyts, J, del Rios, M, Rodriguez-Morales, AJ, Rosa-Freitas, MG, Sall, A, Simmons, G, Simon, F, Rua, AV, and Glo, PIDRCOn-n

Published
2019

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