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934 results on '"Neyses, Ludwig"'

4. Selective inhibition of plasma membrane calcium ATPase 4 improves angiogenesis and vascular reperfusion

Author

Kurusamy, Sathishkumar, López-Maderuelo, Dolores, Little, Robert, Cadagan, David, Savage, Aaron M., Ihugba, Jude C., Baggott, Rhiannon R., Rowther, Farjana B., Martínez-Martínez, Sara, Arco, Pablo Gómez-del, Murcott, Clare, Wang, Weiguang, Francisco Nistal, J., Oceandy, Delvac, Neyses, Ludwig, Wilkinson, Robert N., Cartwright, Elizabeth J., Redondo, Juan Miguel, and Armesilla, Angel Luis

Published
2017
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14. The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial

Author

Cleland, John GF, Teerlink, John R, Senior, Roxy, Nifontov, Evgeny M, Mc Murray, John JV, Lang, Chim C, Tsyrlin, Vitaly A, Greenberg, Barry H, Mayet, Jamil, Francis, Darrel P, Shaburishvili, Tamaz, Monaghan, Mark, Saltzberg, Mitchell, Neyses, Ludwig, Wasserman, Scott M, Lee, Jacqueline H, Saikali, Khalil G, Clarke, Cyril P, Goldman, Jonathan H, Wolff, Andrew A, and Malik, Fady I

Published
2011
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29. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: The Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD).

Author

Rydén, Lars, Grant, Peter J., Anker, Stefan D., Berne, Christian, Cosentino, Francesco, Danchin, Nicolas, Deaton, Christi, Escaned, Javier, Hammes, Hans-Peter, Huikuri, Heikki, Marre, Michel, Marx, Nikolaus, Mellbin, Linda, Ostergren, Jan, Patrono, Carlo, Seferovic, Petar, Uva, Miguel Sousa, Taskinen, Marja-Riita, Tendera, Michal, Tuomilehto, Jaakko, Valensi, Paul, Zamorano, Jose Luis, Zamorano, Jose Luis, Achenbach, Stephan, Baumgartner, Helmut, Bax, Jeroen J., Bueno, Héctor, Dean, Veronica, Deaton, Christi, Erol, Çetin, Fagard, Robert, Ferrari, Roberto, Hasdai, David, Hoes, Arno W., Kirchhof, Paulus, Knuuti, Juhani, Kolh, Philippe, Lancellotti, Patrizio, Linhart, Ales, Nihoyannopoulos, Petros, Piepoli, Massimo F., Ponikowski, Piotr, Sirnes, Per Anton, Tamargo, Juan Luis, Tendera, Michal, Torbicki, Adam, Wijns, William, Windecker, Stephan, De Backer, Guy, Sirnes, Per Anton, Ezquerra, Eduardo Alegria, Avogaro, Angelo, Badimon, Lina, Baranova, Elena, Baumgartner, Helmut, Betteridge, John, Ceriello, Antonio, Fagard, Robert, Funck-Brentano, Christian, Gulba, Dietrich C., Hasdai, David, Hoes, Arno W., Kjekshus, John K., Knuuti, Juhani, Kolh, Philippe, Lev, Eli, Mueller, Christian, Neyses, Ludwig, Nilsson, Peter M., Perk, Joep, Ponikowski, Piotr, Reiner, Željko, Sattar, Naveed, Schächinger, Volker, Scheen, André, Schirmer, Henrik, Strömberg, Anna, Sudzhaeva, Svetlana, Tamargo, Juan Luis, Viigimaa, Margus, Vlachopoulos, Charalambos, and Xuereb, Robert G.

Published
2013
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34. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC)

Author

Hamm, Christian W., Bassand, Jean-Pierre, Agewall, Stefan, Bax, Jeroen, Boersma, Eric, Bueno, Hector, Caso, Pio, Dudek, Dariusz, Gielen, Stephan, Huber, Kurt, Ohman, Magnus, Petrie, Mark C., Sonntag, Frank, Uva, Miguel Sousa, Storey, Robert F., Wijns, William, Zahger, Doron, Bax, Jeroen J., Auricchio, Angelo, Baumgartner, Helmut, Ceconi, Claudio, Dean, Veronica, Deaton, Christi, Fagard, Robert, Funck-Brentano, Christian, Hasdai, David, Hoes, Arno, Knuuti, Juhani, Kolh, Philippe, McDonagh, Theresa, Moulin, Cyril, Poldermans, Don, Popescu, Bogdan A., Reiner, Željko, Sechtem, Udo, Sirnes, Per Anton, Torbicki, Adam, Vahanian, Alec, Windecker, Stephan, Windecker, Stephan, Achenbach, Stephan, Badimon, Lina, Bertrand, Michel, Bøtker, Hans Erik, Collet, Jean-Philippe, Crea, Filippo, Danchin, Nicolas, Falk, Erling, Goudevenos, John, Gulba, Dietrich, Hambrecht, Rainer, Herrmann, Joerg, Kastrati, Adnan, Kjeldsen, Keld, Kristensen, Steen Dalby, Lancellotti, Patrizio, Mehilli, Julinda, Merkely, Béla, Montalescot, Gilles, Neumann, Franz-Josef, Neyses, Ludwig, Perk, Joep, Roffi, Marco, Romeo, Francesco, Ruda, Mikhail, Swahn, Eva, Valgimigli, Marco, Vrints, Christiaan JM, and Widimsky, Petr

Published
2011
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45. Reduced expression of PMCA1 is associated with increased blood pressure with age which is preceded by remodelling of resistance arteries

Author

Little, Robert, Zi, Min, Hammad, Sally K., Nguyen, Loan, Njegic, Alexandra, Kurusamy, Sathishkumar, Prehar, Sukhpal, Armesilla, Angel L, Neyses, Ludwig, Austin, Clare, and Cartwright, Elizabeth

Subjects
Male, Mice, Knockout, Aging, Heterozygote, hypertension, plasma membrane calcium ATPase, Myography, blood pressure, Gene Expression, Original Articles, ATP2B1, Vascular Remodeling, arterial remodeling, Mesenteric Arteries, arterial remodelling, Mice, Inbred C57BL, Mice, Plasma Membrane Calcium-Transporting ATPases, PMCA, Blood pressure, Animals, Original Article, Calcium, Vascular Resistance
Abstract

Hypertension is a well-established risk factor for adverse cardiovascular events and older age is a risk factor for the development of hypertension. Genome wide association studies have linked ATP2B1, the gene for the plasma membrane calcium ATPase 1 (PMCA1), to blood pressure (BP) and hypertension. Here we present the effects of reduction in the expression of PMCA1 on BP and small artery structure and function when combined with advancing age. Heterozygous PMCA1 null mice (PMCA1Ht) were generated and conscious BP was measured at 6 to 18 months of age. Passive and active properties of isolated small mesenteric arteries were examined by pressure myography. PMCA1Ht mice exhibited normal BP at 6 and 9 months of age but developed significantly elevated BP when compared to age matched wild type controls at ≥ 12 months of age. Decreased lumen diameter, increased wall thickness and increased wall:lumen ratio was observed in small mesenteric arteries from animals 9 months of age and older, indicative of eutrophic remodeling. Increases in mesenteric artery intrinsic tone and global intracellular calcium were evident in animals at both 6 and 18 months of age.Thus, decreased expression of PMCA1 is associated with increased BP when combined with advancing age. Changes in arterial structure precede the elevation of BP. Pathways involving PMCA1 may be a novel target for BP regulation in the elderly.

Published
2017

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