Search

Your search keyword '"Newsome, Isabel G."' showing total 19 results
Start Over Author "Newsome, Isabel G."
19 results on '"Newsome, Isabel G."'

4. Precision mouse models with expanded tropism for human pathogens

Author

Wahl, Angela, De, Chandrav, Abad Fernandez, Maria, Lenarcic, Erik M., Xu, Yinyan, Cockrell, Adam S., Cleary, Rachel A., Johnson, Claire E., Schramm, Nathaniel J., Rank, Laura M., Newsome, Isabel G., Vincent, Heather A., Sanders, Wes, Aguilera-Sandoval, Christian R., Boone, Allison, Hildebrand, William H., Dayton, Paul A., Baric, Ralph S., Pickles, Raymond J., Braunstein, Miriam, Moorman, Nathaniel J., Goonetilleke, Nilu, and Victor Garcia, J.

Published
2019
Full Text
View/download PDF

6. Acoustic Molecular Imaging Beyond the Diffraction Limit In Vivo

Author

Kierski, Thomas M., primary, Walmer, Rachel W., additional, Tsuruta, James K., additional, Yin, Jianhua, additional, Cherin, Emmanuel, additional, Foster, F. Stuart, additional, Demore, Christine E. M., additional, Newsome, Isabel G., additional, Pinton, Gianmarco F., additional, and Dayton, Paul A., additional

Published
2022
Full Text
View/download PDF

12. Super Harmonic Ultrasound Localization Microscopy

Author

Kierski, Thomas M., primary, Espindola, David, additional, Newsome, Isabel G., additional, Cherin, Emmanuel, additional, Yin, Jianhua, additional, Foster, F. Stuart, additional, Demore, Christine E., additional, Pinton, Gianmarco F., additional, and Dayton, Paul A., additional

Published
2019
Full Text
View/download PDF

18. Precision mouse models with expanded tropism for human pathogens

Author

Dayton, Paul A., De, Chandrav, Boone, Allison, Baric, Ralph S., Braunstein, Miriam, Sanders, Wes, Goonetilleke, Nilu, Cockrell, Adam S., Hildebrand, William H., Wahl, Angela, Garcia, J. Victor, Aguilera-Sandoval, Christian R., Vincent, Heather A., Newsome, Isabel G., Johnson, Claire E., Pickles, Raymond J., Moorman, Nathaniel J., Cleary, Rachel A., Fernandez, Maria Abad, Rank, Laura M., Lenarcic, Erik M., Schramm, Nathaniel J., and Xu, Yinyan

Subjects
3. Good health
Abstract

A major limitation of current humanized mouse models is that they primarily enable the analysis of human-specific pathogens that infect hematopoietic cells. However, most human pathogens target other cell types, including epithelial, endothelial and mesenchymal cells. Here, we show that implantation of human lung tissue, which contains up to 40 cell types, including nonhematopoietic cells, into immunodeficient mice (lung-only mice) resulted in the development of a highly vascularized lung implant. We demonstrate that emerging and clinically relevant human pathogens such as Middle East respiratory syndrome coronavirus, Zika virus, respiratory syncytial virus and cytomegalovirus replicate in vivo in these lung implants. When incorporated into bone marrow/liver/thymus humanized mice, lung implants are repopulated with autologous human hematopoietic cells. We show robust antigen-specific humoral and T-cell responses following cytomegalovirus infection that control virus replication. Lung-only mice and bone marrow/liver/thymus-lung humanized mice substantially increase the number of human pathogens that can be studied in vivo, facilitating the in vivo testing of therapeutics.

19. Acoustic Angiography: Superharmonic Contrast-Enhanced Ultrasound Imaging for Noninvasive Visualization of Microvasculature.

Author

Newsome IG and Dayton PA

Subjects
Acoustics, Contrast Media, Microbubbles, Microvessels diagnostic imaging, Ultrasonography, Angiography
Abstract

Acoustic angiography is a contrast-enhanced ultrasound technique that relies on superharmonic imaging to form high-resolution, three-dimensional maps of the microvasculature. In order to obtain signal separation between tissue and contrast, acoustic angiography has been performed with dual-frequency transducers with nonoverlapping bandwidths. This enables a high contrast-to-tissue ratio, and the choice of a high frequency receiving element provides high resolution. In this chapter, we describe the technology behind acoustic angiography as well as the step-by-step implementation of this contrast enhanced microvascular imaging technique., (© 2022. Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results