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5. Structure Elucidation of Pharmaceutically Relevant Compounds Within Pyrene‐Based Frameworks.

12. Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections

13. Manufacturing Process Development for the Biaryl Ether Fragment of Nemtabrutinib (MK-1026)

21. Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections.

24. Leveraging Synergistic Solubility in the Development of a Direct Isolation Process for Nemtabrutinib

25. Utilizing biocatalysis and a sulfolane-mediated reductive acetal opening to access nemtabrutinib from cyrene

27. Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19.

29. Utilizing Biocatalysis and an Unprecedented Sulfolane-mediated Reductive Acetal Opening to Access Nemtabrutinib from Cyrene

31. Contributors

37. Progression of central nervous system disease from pediatric to young adulthood in sickle cell anemia

41. Development of an Efficient Route to 2-Ethynylglycerol for the Synthesis of Islatravir

43. Cover Feature: Five‐Step Enantioselective Synthesis of Islatravir via Asymmetric Ketone Alkynylation and an Ozonolysis Cascade (Chem. Eur. J. 62/2020)

47. Serum cytokine levels are modulated by specific frequencies, amplitudes, and pulse widths of vagus nerve stimulation

49. Progression of Central Nervous System Vasculopathy in Young Adults with Sickle Cell Anemia

50. Modality of wound closure after total knee replacement: are staples as safe as sutures? A retrospective study of 181 patients

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