45 results on '"Nevin Dinccag"'
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2. A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria
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Yildiz Tutuncu, Ilhan Satman, Selda Celik, Nevin Dinccag, Kubilay Karsidag, Aysegul Telci, Sema Genc, Halim Issever, Jaakko Tuomilehto, and Beyhan Omer
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Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) have been used to diagnose new-onset diabetes mellitus (DM) in order to simplify the diagnostic tests compared with the 2-hour oral glucose tolerance test (OGTT; 2-hPG). We aimed to identify optimal cut-off points of high sensitive C-reactive protein (hs-CRP) in new-onset DM people based on FPG, 2-hPG, or HbA1c methods. Data derived from recent population-based survey in Turkey (TURDEP-II). The study included 26,499 adult people (63% women, response rate 85%). The mean serum concentration of hs-CRP in women was higher than in men (p
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- 2016
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3. Inflammatory markers are associated with the progression of gestational diabetes to metabolic syndrome
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Bulent Can, Yildiz Tutuncu, Busra Can, Havva Keskin, Seldag Bekpinar, and Nevin Dinccag
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Inflammation ,Metabolic Syndrome ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,Obstetrics and Gynecology ,Diabetes, Gestational ,C-Reactive Protein ,Pregnancy ,Plasminogen Activator Inhibitor 1 ,Humans ,Female ,Adiponectin ,Nicotinamide Phosphoribosyltransferase ,Biomarkers ,Retrospective Studies - Abstract
The progression of gestational diabetes mellitus (GDM) to metabolic syndrome (MetS) is associated with systemic inflammation. The aim of this study was to compare the levels of inflammatory markers in former GDM patients with and without MetS. Medical records were screened retrospectively for patients who were diagnosed with GDM 10 (±2) years ago. Former GDM patients were invited to the hospital for an assessment of their current health status. Of 52 women with former GDM, 27 (52%) had MetS. C-reactive protein (CRP), interleukin-6 and plasminogen activator inhibitor-1 (PAI-1) levels were significantly higher in the MetS group while adiponectin was significantly lower (
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- 2022
4. Comparison of amylase and lipase levels of patients with Type 2 diabetes under different treatment modalities
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Ramazan Çakmak, Seher Tanrikulu, Mehmet S Koc, Nevin Dinccag, Hulya Hacisahinogullari, Ozge Telci Caklili, and Sakin Tekin
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Clinical Biochemistry ,Incretin ,Type 2 diabetes ,Incretins ,Glucagon ,Cohort Studies ,Internal medicine ,Drug Discovery ,medicine ,Humans ,Hypoglycemic Agents ,Insulin ,Amylase ,Lipase ,Aged ,Glycated Hemoglobin ,Dipeptidyl-Peptidase IV Inhibitors ,biology ,business.industry ,Biochemistry (medical) ,Middle Aged ,medicine.disease ,Metformin ,Endocrinology ,Diabetes Mellitus, Type 2 ,Amylases ,biology.protein ,Female ,business ,Pioglitazone ,medicine.drug - Abstract
Aim: Study aims to assess amylase, lipase of patients with Type 2 diabetes under different types of treatments. Materials & methods: Patients’ treatment modalities including insulin, metformin, pioglitazone, sodium-glucose co-transporter-2 inhibitors, insulin secretagogues, dipeptidyl peptidase-4 inhibitors and glucagon like peptide-1 receptor agonists were compared. Results: There was no difference in amylase and lipase levels between dipeptidyl peptidase-4 inhibitor users and non-users (p = 0.2, p = 0.3, respectively) and glucagon like peptide-1 analog users and non-users (p = 0.1, p = 0.7, respectively). Patients who use insulin secretagogues had significantly higher amylase, lipase (77.2 ± 39.8 vs 69.5 ± 33.0, p = 0.038 and 47.2 ± 33.2 vs 39.6 ± 26.8, p = 0.01, respectively) and patients on basal insulin had lower amylase levels (69.9 ± 37.7 vs 77.2 ± 33.7, p = 0.014). Conclusion: Incretin-based therapies showed no difference in amylase and lipase levels whereas there was increase with secretagogues and decrease with basal insulin.
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- 2022
5. Risk factors predicting the development of diabetes mellitus and metabolic syndrome following gestational diabetes mellitus
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Nevin Dinccag, Bulent Can, Gulsah Yenidunya Yalin, and Sema Ciftci
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Adult ,Blood Glucose ,medicine.medical_specialty ,endocrine system diseases ,medicine.medical_treatment ,Article ,Insulin resistance ,Pregnancy ,Risk Factors ,insulin resistance ,Diabetes mellitus ,Internal medicine ,medicine ,Humans ,Metabolic Syndrome ,business.industry ,Insulin ,Diabetes ,nutritional and metabolic diseases ,Type 2 Diabetes Mellitus ,General Medicine ,medicine.disease ,Obesity ,Gestational diabetes ,Diabetes, Gestational ,Diabetes Mellitus, Type 2 ,Female ,gestational diabetes ,Metabolic syndrome ,business - Abstract
Background/aim To determine risk factors associated with the development of insulin resistance, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MetS) in gestational diabetes mellitus (GDM) patients 10 years after giving birth. Materials and methods Medical records of patients with former GDM were screened. Eligible patients were invited to the hospital to obtain information about their present health status. Patients with pregestational diabetes and patients with multiple pregnancies were excluded. A total of 67 women formed the study group. American Diabetes Association (ADA) and International Diabetes Federation (IDF) criteria were used to define T2DM and MetS, respectively. Results A total of 27 patients developed diabetes (40.3%) and 35 patients (52%) developed MetS. T2DM developed, on average, 4.8 years after delivery. There was a significant difference between diabetic and nondiabetic patients in terms of insulin use during pregnancy (P < 0.001). Women who developed diabetes within 10 years after giving birth were observed to have significantly higher fasting plasma glucose on oral glucose tolerance test during their pregnancy (P = 0.007). Current and pregestational body mass indices had a significant effect on the development of MetS (P = 0.003 and P = 0.027, respectively). Conclusion In this long-term study, we found that patients with high fasting plasma glucose (FPG) and insulin requirement during pregnancy are at an increased risk of developing T2DM, while pregestational obesity is predictive of progression to MetS. Identifying and targeting high-risk individuals may delay and possibly prevent T2DM and MetS.
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- 2021
6. Expert Panel Recommendations for Use of Standardized Glucose Reporting System Based on Standardized Glucometrics Plus Visual Ambulatory Glucose Profile (AGP) Data in Clinical Practice
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Selcuk, Dagdelen, Oguzhan, Deyneli, Nevin, Dinccag, Hasan, Ilkova, Zeynep, Osar Siva, Ilhan, Yetkin, and Temel, Yilmaz
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Blood Glucose ,Glycated Hemoglobin ,algorithm ,Blood Glucose Self-Monitoring ,Endocrinology, Diabetes and Metabolism ,Disease Management ,Monitoring, Ambulatory ,clinical utility ,Review ,Reference Standards ,RC648-665 ,Diseases of the endocrine glands. Clinical endocrinology ,expert opinion ,Endocrinology ,Practice Guidelines as Topic ,Diabetes Mellitus ,Humans ,continuous glucose monitoring ,ambulatory glucose profile ,diabetes care - Abstract
This expert panel of diabetes specialists aimed to provide guidance to healthcare providers on the best practice in the use of innovative continuous glucose monitoring (CGM) techniques through a practical and implementable document that specifically addresses the rationale for and also analysis and interpretation of the new standardized glucose reporting system based on standardized CGM metrics and visual ambulatory glucose profile (AGP) data. This guidance document presents recommendations and a useful algorithm for the use of a standardized glucose reporting system in the routine diabetes care setting.
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- 2022
7. Acidosis is not a sine qua non for DKA
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Vefa Nasifova, Göktuğ Sarıbeyliler, Ramazan Cakmak, Nurdan Gul, Caklili Ozge Telci, Kubilay Karșıdağ, Ayșenur Yılmaz, Ummu Mutlu, Nevin Dinccag, Caner Kapar, Cemile Idiz, Çelik Ayșe Merve, and Alpay Alibeyoğlu
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medicine.medical_specialty ,Sine qua non ,business.industry ,Internal medicine ,Cardiology ,medicine ,medicine.symptom ,business ,Acidosis - Published
- 2020
8. Diyabetlilerde Kendi Kendine Kan Şekeri İzlemi ile HbA1c ve Diyabet Komplikasyonlarının Karşılaştırılması
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Ilhan Satman, Elif Bagdemir, Sevim Purisa, Nevin Dinccag, Selda Celik, and Cemile Idiz
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medicine.medical_specialty ,Type 1 diabetes ,business.industry ,Type 2 diabetes ,medicine.disease ,Gastroenterology ,Diabetic foot ,Nephropathy ,Internal medicine ,Diabetes mellitus ,Medicine ,Hemoglobin ,Blood Glucose Measurement ,business ,Retinopathy - Abstract
Aim: This study aimed to determine the relationship between the frequency of measuring blood glucose levels and the complications and regulation of diabetes in patients under follow-up due to diabetes mellitus. Subjects and Method: This study was conducted via retrospective evaluation of patient files of 951 diabetics (90 with type 1 diabetes and 861 with type 2 diabetes). Patient information including age, gender, height, weight, type of diabetes, duration of diabetes, treatment of diabetes, hemoglobin A1c (HbA1c) value, presence of neuropathy, presence of nephropathy, presence of diabetic foot, presence of hypertension, and frequency of measuring blood glucose levels were recorded. Patients were divided into 3 groups by the frequency of measuring blood glucose levels, where those who measured blood glucose levels a total of 8 times for at least two days a week were assigned to group 1, those who measured blood glucose levels less than 8 times for less than two days a week were assigned to group 2, and those who measured blood glucose levels 8 times in the 2 days prior to the control visit, who had previously measured blood glucose levels in an irregular manner were assigned to group 3. Results: Of the patients, 548 were females and 403 were males, with a mean age of 58.12±13.17 years. There was a significant difference in the parameters of HbA1c (p
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- 2018
9. Use of Biphasic Insulin Aspart 30 in Type 2 Diabetes Treatment: Expert Panel Recommendations
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Sevim Güllü, Abdurrahman Comlekci, Hasan Aydin, Kursad Unluhizarci, Nevin Dinccag, Sema Akalin, Mustafa Kemal Balci, Halil Önder Ersöz, Dilek Gogas Yavuz, Zeynep Siva, Ibrahim Sahin, and Tomris Erbas
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medicine.medical_specialty ,business.industry ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Type 2 diabetes ,030204 cardiovascular system & hematology ,medicine.disease ,Biphasic insulin aspart ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Internal Medicine ,Medicine ,business - Abstract
The goals of Type 2 diabetes treatment are to eliminate the hyperglycemia resulting from insulin insufficiency and/or insulin resistance, delay beta cell damage/depletion, and prevent other metabolic co-morbidities and complications. In the current treatment algorithms, lifestyle changes (medical nutrition therapy, physical exercise) and oral anti-diabetics are followed by insulin therapy, which is considered a replacement therapy for Type 2 diabetes. Pre-mixed insulin preparations, which are an option for patients with poor blood glucose level control under oral anti-diabetics treatment, have been developed to meet both basal and prandial insulin needs by simulating the physiological changes in insulin levels. The consensus on the necessity of individualizing insulin therapy requires physicians to have a detailed knowledge of the various uses of insulin. Therefore, this comprehensive consensus statement has been prepared by a panel of expert endocrinologists from different regions of Turkey to help physicians use biphasic insulin aspart 30 in suitable patients at the right time. In this statement, expert panel opinions on (a) Recommendations for the appropriate initiation, titration, and intensification of insulin treatment, and (b) The treatment algorithms in initiation, titration, and intensification of biphasic insulin aspart 30 treatment and special conditions specific to changing treatment regimen are presented.
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- 2018
10. Patterns and preferences of antidiabetic drug use in Turkish patients with type 2 diabetes – A nationwide cross-sectional study (TEMD treatment study)
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Tevfik Sabuncu, Ibrahim Demirci, Murat Yilmaz, Seda Sancak, Guzin Fidan Yaylali, Yuksel Altuntas, Ilhan Satman, Nevin Dinccag, Cem Haymana, Alper Sonmez, Fahri Bayram, and Irfan Nuhoglu
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Male ,Drug ,medicine.medical_specialty ,Turkey ,endocrine system diseases ,Cross-sectional study ,Endocrinology, Diabetes and Metabolism ,media_common.quotation_subject ,medicine.medical_treatment ,030209 endocrinology & metabolism ,Type 2 diabetes ,Diabetic complications ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Complex treatment regimens ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,Humans ,Hypoglycemic Agents ,Insulin ,Medicine ,030212 general & internal medicine ,Oral antidiabetics ,media_common ,business.industry ,nutritional and metabolic diseases ,General Medicine ,Middle Aged ,medicine.disease ,Metformin ,Cross-Sectional Studies ,Blood pressure ,Diabetes Mellitus, Type 2 ,Basal (medicine) ,Female ,business ,medicine.drug - Abstract
AIMS: The treatment preferences in type 2 diabetes (T2DM) are affected by multiple factors. This survey aims to find out the profiles of the utilization of antidiabetics and their determinants. METHODS: The nationwide, multicenter TEMD survey consecutively enrolled patients with T2DM (n = 4678). Medications including oral antidiabetics (OAD) and injectable regimens were recorded. Multiple injectable regimens with or without OADs were defined as complex treatments. RESULTS: A total of 4678 patients with T2DM (mean age: 58.5 ± 10.4 years, 59% female) were enrolled. More than half of patients (n = 2372; 50.7%) were using injectable regimens with or without OADs, and others (n = 2306, 49.3%) were using only OADs. The most common OADs were metformin (93.5%), secretagogues (40.1%), and DPP-4 inhibitors (37.2%). The rates of the use of basal, basal-bolus and premix insulin were 26.5%, 39.5% and 22.4%, respectively. Patients using OADs achieved better glycemia, blood pressure and weight control (pÂ
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- 2021
11. Lower Urinary Tract Symptoms in Women With Type 2 Diabetes Mellitus
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Gülay Rathfisch, Meltem Demirgöz Bal, Nevin Dinccag, Nezihe Kizilkaya Beji, Onay Yalcin, Selda Celik, Sema Yilmaz, and Biruni Üniversitesi
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Adult ,medicine.medical_specialty ,Stress incontinence ,Turkey ,030232 urology & nephrology ,Urinary incontinence ,Ambulatory Care Facilities ,03 medical and health sciences ,0302 clinical medicine ,Lower Urinary Tract Symptoms ,Obstetrics and gynaecology ,Quality of life ,Risk Factors ,Lower urinary tract symptoms ,Surveys and Questionnaires ,Internal medicine ,Diabetes Mellitus ,Prevalence ,medicine ,Humans ,Nocturia ,Outpatient clinic ,Women ,Advanced and Specialized Nursing ,030219 obstetrics & reproductive medicine ,business.industry ,Smoking ,Age Factors ,Urination disorder ,Middle Aged ,Urination Disorders ,medicine.disease ,Medical–Surgical Nursing ,Urinary Incontinence ,Diabetes Mellitus, Type 2 ,Physical therapy ,Female ,medicine.symptom ,business - Abstract
Purpose: The aim of the study was to compare lower urinary tract symptoms (LUTS) in women with and without type 2 diabetes mellitus (DM). Subjects and Setting: The sample was drawn from community-dwelling women in the province of Istanbul who were cared for in the diabetes outpatient clinic of Istanbul Medical School between January and June 2012. Two hundred forty-nine women with DM were compared to 255 women without DM cared for in the obstetrics and gynecology department of the same university hospital. The mean ages of the groups were 55.1 and 53.7 years, respectively. Methods: Participants completed a questionnaire that queried sociodemographic and clinical characteristics; the Bristol Female Lower Urinary Tract Symptoms-Short Form (BFLUTS-SF) was used to evaluate LUTS. The questionnaire required 10 to 15 minutes to complete; participants completed the questionnaire in a private room of each of the respective outpatient clinics. Results: No statistically significant differences were found when groups (women with and without DM) were compared based on age and cigarette smoking (P > .05). In contrast, BMI scores were significantly higher in the women with DM (P < .001). The cumulative BFLUTS scores and the filling and incontinence symptoms subscale sores (P < .001) were significantly higher in women with DM. No differences were observed in voiding symptoms (P = .347), sexual function (P = .380), and health-related quality of life (P = .142) subscale scores. The prevalence of storage symptoms nocturia, voiding frequency, urge incontinence, stress incontinence, frequency of incontinent episodes were higher among women with DM. In addition, women with DM were more likely to report the need to change clothing because of urinary leakage, effect of incontinence on daily tasks, and overall interference with daily activities of living. Conclusions: Women with type 2 DM are more likely to experience LUTS as compared to women without DM. Women with type 2 DM should routinely be assessed for LUTS.
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- 2016
12. Utility of DN4 questionnaire in assessment of neuropathic pain and its clinical correlations in Turkish patients with diabetes mellitus
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Nevin Dinccag, E. Temel, Sevim Purisa, G. Cinkil, Nurdan Gul, G. Yenidunya, Ilhan Satman, S. Celik, and A. Kubat Uzum
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Blood Glucose ,Male ,medicine.medical_specialty ,Time Factors ,Turkey ,Endocrinology, Diabetes and Metabolism ,Physical examination ,Type 2 diabetes ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Diabetic Neuropathies ,Predictive Value of Tests ,Risk Factors ,Surveys and Questionnaires ,Diabetes mellitus ,Internal medicine ,Severity of illness ,Odds Ratio ,Internal Medicine ,medicine ,Humans ,Hypoglycemic Agents ,Outpatient clinic ,030212 general & internal medicine ,Aged ,Pain Measurement ,Glycated Hemoglobin ,Chi-Square Distribution ,Diabetic Retinopathy ,Nutrition and Dietetics ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,Odds ratio ,Diabetic retinopathy ,Middle Aged ,medicine.disease ,Cross-Sectional Studies ,Logistic Models ,Diabetes Mellitus, Type 2 ,Physical therapy ,Female ,Family Practice ,business ,Biomarkers ,030217 neurology & neurosurgery ,Retinopathy - Abstract
We aimed to assess the utility of DN4 questionnaire (Douleur Neuropathique en 4 questions) to define the frequency and severity of neuropathic pain (NP) and also its clinical correlation to daily clinical practice.We included 1357 patients with diabetes (56.5% women, 90.4% type 2 diabetes) who were followed up in our diabetes outpatient clinic. Presence of NP was evaluated by performing simultaneous DN4 questionnaires and physical examination. Those who had a DN4 score ≥4 were considered to have NP.The mean age was 58.2±12.1 years, mean duration was 12.5±7.5; (min-max: 1-45) years, mean HbA1c level was 7.8±1.6% (min-max: 5-16.2%), (61.7±6.0mmol/mol; min-max: 31.1-153.6mmol/mol). Three hundred thirteen patients (23%) were diagnosed with NP using the DN4 tool. Male gender (p=0.01), receiving antihypertensive treatment (p=0.01), presence of retinopathy (p0.001), cardiovascular disease (CVD) (p=0.01) and previously diagnosed neuropathy (p0.001) were significantly associated with higher NP scores. Those who had increased DN4 scores were more likely to be on oral hypoglycemic agents (OHA)+insulin combinations (p0.001), had longer diabetes duration (p0.001) and higher HbA1c levels (p=0.001). Logistic regression model revealed that diabetes duration (OR: 1.02, 95% CI: 1.00-1.04, p=0.007), elevated HbA1c levels (1.11, 1.02-1.21, 0.015), presence of retinopathy (1.41, 1.20-1.64,0.001), management with at least one OHA (1.47; 1.12-1.92; 0.004) or any insulin regimen (1.62; 1.16-2.27; 0.005) (compared with diet only-regimens) were significantly associated with NP.Utilization of DN4 questionnaire in daily clinical practice is an effective tool in the identification of pain related with peripheral diabetic polyneuropathy.
- Published
- 2016
13. A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria
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Ilhan Satman, Beyhan Omer, Jaakko Tuomilehto, Halim Issever, Kubilay Karsidag, Selda Celik, Sema Genc, Nevin Dinccag, Aysegul Telci, and Yildiz Tutuncu
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Blood Glucose ,Male ,Time Factors ,Turkey ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,030204 cardiovascular system & hematology ,Bioinformatics ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Gastroenterology ,0302 clinical medicine ,Endocrinology ,Oral glucose tolerance ,Response rate (survey) ,Glucose tolerance test ,education.field_of_study ,medicine.diagnostic_test ,biology ,Fasting ,Middle Aged ,3. Good health ,C-Reactive Protein ,Area Under Curve ,Predictive value of tests ,Female ,Research Article ,Adult ,medicine.medical_specialty ,Article Subject ,Population ,030209 endocrinology & metabolism ,03 medical and health sciences ,Predictive Value of Tests ,Diabetes mellitus ,Internal medicine ,Diabetes Mellitus ,medicine ,Humans ,education ,Glycated Hemoglobin ,lcsh:RC648-665 ,business.industry ,C-reactive protein ,Reproducibility of Results ,nutritional and metabolic diseases ,Glucose Tolerance Test ,medicine.disease ,ROC Curve ,biology.protein ,Hemoglobin ,business ,Biomarkers - Abstract
Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) have been used to diagnose new-onset diabetes mellitus (DM) in order to simplify the diagnostic tests compared with the 2-hour oral glucose tolerance test (OGTT; 2-hPG). We aimed to identify optimal cut-off points of high sensitive C-reactive protein (hs-CRP) in new-onset DM people based on FPG, 2-hPG, or HbA1c methods. Data derived from recent population-based survey in Turkey (TURDEP-II). The study included 26,499 adult people (63% women, response rate 85%). The mean serum concentration of hs-CRP in women was higher than in men (p<0.001). The people with new-onset DM based on HbA1c had higher mean hs-CRP level than FPG based and 2-hPG based DM cases. In HbA1c, 2-hPG, and FPG based new-onset DM people, cut-off levels of hs-CRP in women were 2.9, 2.1, and 2.5 mg/L [27.5, 19.7, and 23.5 nmol/L] and corresponding values in men were 2.0, 1.8, and 1.8 mg/L (19.0, 16.9, and 16.9 nmol/L), respectively (sensitivity 60–65% and specificity 54–64%). Our results revealed that hs-CRP may not further strengthen the diagnosis of new-onset DM. Nevertheless, the highest hs-CRP level observed in new-onset DM people diagnosed with HbA1c criterion supports the general assumption that this method might recognize people in more advanced diabetic stage compared with other diagnostic methods.
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- 2016
14. The effect of nephropathy on plasma sphingosine 1-phosphate concentrations in patients with type 2 diabetes
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Esra Aycan-Ustyol, Figen Gurdol, G Yenidunya, Seldag Bekpinar, Nevin Dinccag, and Yesim Unlucerci
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Male ,medicine.medical_specialty ,Clinical Biochemistry ,Apolipoproteins M ,Type 2 diabetes ,Biology ,Arginine ,Nephropathy ,Diabetic nephropathy ,chemistry.chemical_compound ,Sphingosine ,Internal medicine ,medicine ,Albuminuria ,Humans ,Diabetic Nephropathies ,Endothelial dysfunction ,Triglycerides ,Cholesterol, HDL ,Albumin ,Biological Transport ,Cholesterol, LDL ,General Medicine ,Middle Aged ,medicine.disease ,Lipocalins ,Apolipoproteins ,Endocrinology ,Diabetes Mellitus, Type 2 ,chemistry ,Female ,lipids (amino acids, peptides, and proteins) ,Microalbuminuria ,Lysophospholipids ,medicine.symptom ,Asymmetric dimethylarginine - Abstract
Objectives Sphingosine 1-phosphate (S1P) is carried in plasma by the HDL particles and albumin. It mediates several protective functions of HDL. Because of its barrier-enhancing effect, it has attracted attention in diseases associated with endothelial dysfunction. We examined the impact of circulating levels of S1P in diabetic nephropathy together with apoprotein M, a S1P-binding protein in HDL. Plasma levels of dimethylarginines were evaluated in this context. Design and methods Patients with type 2 diabetes mellitus were divided into three groups according to daily albumin excretion: normoalbuminuria, microalbuminuria and macroalbuminuria (n = 30 in each). In addition to routine analysis, S1P and apo M in plasma were measured using the enzyme-linked immunosorbent assays. Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and l -arginine were determined by HPLC. Tukey's or Mann–Whitney U-test was used for the statistics. Results Plasma S1P levels showed a significant decline in parallel to kidney dysfunction. The highest significance was detected in the macroalbuminuric group. Although a significant increase in plasma SDMA in albuminuric groups was observed, apo M, l -arginine and ADMA levels were similar between the groups. Conclusion Low plasma levels of S1P seemed to be associated with diabetic nephropathy. The main reason for the decreased S1P levels in our patients seems to be severe urinary albumin loss due to nephropathy. Low levels of S1P in patients with nephropathy may adversely affect the endothelial integrity and barrier function, thus causing a vicious circle.
- Published
- 2015
15. Postprandial glucose, insulin, and incretin responses to different type of breads in healthy overweight and obese individuals
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Nevin Dinccag, Merve Kayali, Yildiz Tutuncu, and Duman Sebiha Ozge
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medicine.medical_specialty ,Postprandial ,Endocrinology ,business.industry ,Internal medicine ,Insulin ,medicine.medical_treatment ,Medicine ,Incretin ,Overweight ,medicine.symptom ,business - Published
- 2018
16. The association between glycemic markers and variability with plasma adipocytokine levels and markers of endothelium dysfunction in women with pregestational diabetes mellitus
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Elmire Dervisoglu, Sakin Tekin, Gulsah Yenidunya Yalin, Sema Genc, Seher Tanrikulu, Cemile Idiz, Elif Bagdemir, Nevin Dinccag, and Songul Hatiboglu
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medicine.medical_specialty ,medicine.anatomical_structure ,Endocrinology ,Endothelium ,business.industry ,Internal medicine ,Pregestational Diabetes ,Medicine ,business ,Glycemic - Published
- 2018
17. Turkish nationwide survEy of glycemic and other Metabolic parameters of patients with Diabetes mellitus (TEMD study)
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Guzin Fidan Yaylali, Faruk Kutluturk, Emre Bozkirli, Sait Gonen, Ilhan Satman, Sedat Cetin, Zafer Pekkolay, Demet Corapcioglu, Alper Sonmez, Sibel Guldiken, Zeliha Hekimsoy, Hamide Piskinpasa, Elif Bagdemir, Oguz Dikbas, Mustafa Kemal Balci, Hasan Aydin, T. Dogru, Mustafa Altay, Ilyas Capoglu, Amir Hassein Abedi, Mustafa Cesur, Serkan Yener, Erman Cakal, Guzide Gonca Oruk, Ibrahim Aslan, Ahmet Kaya, Elif Tutku Durmuş, Turkan Mete, Eylem Cagiltay, Berrin Çetinarslan, Belgin Efe, Irfan Nuhoglu, Eren Imre, Mehmet Eren, Sefika Dalkiran, Ozen Oz Gul, Mustafa Kutlu, Engin Güney, Esen Akbay, Ilhan Yetkin, Nur Kebapci, Serpil Salman, Volkan Yumuk, Kamile Gul, Canan Ersoy, Berrin Demirbas, Oguzhan Deyneli, Senay Topsakal, Yusuf Bozkus, Murat Yilmaz, Oguzhan Sitki Dizdar, Seda Sancak, Busra Yildiz, Feyza Yener Ozturk, Yuksel Altuntas, Fulya Turker, Ali Kirik, Ahmet Corakci, Cem Barçın, Rifki Ucler, Tevfik Sabuncu, Sibel Ertek, Bekir Cakir, Ibrahim Demirci, Fahri Bayram, Halil Onder Ersoz, Muge Ozsan Yilmaz, Nevin Dinccag, Mustafa Araz, Okan Yildiz, Levent Ozsari, Hatice Ozisik, Sule Canlar, Murat Dağdeviren, Cemile Idiz, B. Tamer Tetiker, Mehmet Asik, Safak Akin, Mesut Ozkaya, Zehra Capa, S. Nur Boysan, Ferit Kerim Kucukler, Alev Selek, Mustafa Ünübol, Cem Onur Kirac, Ozlem Haliloglu, Semra Ayturk, Ilker Cordan, Neslihan Bascil Tutuncu, Cem Haymana, Alpaslan Kemal Tuzcu, Ibrahim Sahin, Ramazan Cakmak, Pinar Sisman, Eren Gurkan, Basak Ozgen Saydam, Hulya Hacisahinogullari, Sinem Kiyici, Suleyman Nahit Sendur, Taner Bayraktaroglu, Didem Ozdemir, Emin Murat Akbas, Sazi Imamoglu, Ayse Carlioglu, Seher Çetinkaya Altuntaş, Şevki Çetinkalp, Kemal Agbaht, Aysegul Atmaca, Meral Mert, Suleyman Baldane, Gulhan Akbaba, Sonmez, A., Haymana, C., Bayram, F., Salman, S., Dizdar, O.S., Gurkan, E., Kargili Carlıoglu, A., Yeditepe Üniversitesi, Health Sciences University, Gulhane Faculty of Medicine, Department of Endocrinology and MetabolismAnkara, Turkey, Gulhane Training and Research Hospital, Department of Endocrinology and MetabolismAnkara, Turkey, Erciyes University, Faculty of Medicine, Department of Endocrinology and Metabolism, Kayseri, Turkey, Istinye University, Faculty of Medicine, Department of Endocrinology and Metabolism, Istanbul, Turkey, Kayseri Training and Research Hospital, Department of Endocrinology and Metabolism, Kayseri, Turkey, Mustafa Kemal University, Faculty of Medicine, Department of Endocrinology and Metabolism, Hatay, Turkey, Erzurum Training and Research Hospital, Department of Endocrinology and Metabolism, Erzurum, Turkey, Health Sciences University, Gulhane Faculty of Medicine, Department of CardiologyAnkara, Turkey, Harran University, Faculty of Medicine, Sanliurfa, Turkey, Istanbul University, Faculty of Medicine, Istanbul, Turkey, Trakya University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Corlu REYAP Private Hospital, Department of Endocrinology and Metabolism, Turkey, Canakkale 18 March University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Istanbul University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Istanbul University, Cerrahpasa, School of Medicine, Department of Endocrinology and Metabolism, Turkey, University of Health Sciences, School of Medicine, Fatih Sultan Mehmet Training and Research Hospital, Department of Endocrinology and Metabolism, Turkey, University of Health Sciences, School of Medicine, Sultanabdulhamit Training and Research Hospital, Department of Endocrinology and Metabolism, Turkey, Marmara University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Istanbul Science University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, University of Health Sciences, School of Medicine, Sisli Hamidiye Etfal Training and Research Hospital, Department of Endocrinology and Metabolism, Turkey, University of Health Sciences, School of Medicine, İstanbul Bakırkoy Dr. Sadi Konuk Training and Research Hospital, Department of Endocrinology and Metabolism, Turkey, Yeditepe University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Private Office, Turkey, Uludag University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, University of Health Sciences, School of Medicine, Bursa Sevket Yılmaz Training and Research Hospital, Department of Endocrinology and Metabolism, Turkey, Kocaeli University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Balikesir University, School of Medicine, Department of Internal Medicine, Turkey, Eskisehir Osmangazi University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Necmettin Erbakan University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Selcuk University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, University of Health Sciences, Gulhane School of Medicine and Gulhane Training and Research Hospital, Department of Endocrinology and Metabolism, Turkey, Private Guven Hospital, Department of Endocrinology and Metabolism, Turkey, Gazi University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Ankara University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Hacettepe University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Yıldırım Beyazıt University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Ufuk University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Private Bayındır Hospital, Department of Endocrinology and Metabolism, Turkey, Baskent University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, University of Health Sciences, School of Medicine, Diskapi Yildirim Beyazit Training and Research Hospital, Department of Endocrinology and Metabolism, Turkey, TOBB University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Private Memorial Hospital, Department of Endocrinology and Metabolism, Turkey, University of Health Sciences, School of Medicine, Kecioren Training and Research Hospital, Department of Endocrinology and Metabolism, Turkey, Erciyes University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Ege University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, University of Health Sciences, School of Medicine, Izmir Ataturk Training and Research Hospital, Department of Endocrinology and Metabolism, Turkey, Dokuz Eylul University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Adnan Menderes University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Pamukkale University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Celal Bayar University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Mugla University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, University of Health Sciences, School of Medicine, Antalya Training and Research Hospital, Department of Endocrinology and Metabolism, Turkey, Akdeniz University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Mersin University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Kahramanmaras Sutcu Imam University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Private Defne Hospital, Department of Endocrinology and Metabolism, Turkey, Mustafa Kemal University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Baskent University, Adana Training Hospital, Department of Endocrinology and Metabolism, Turkey, Cukurova University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, 19 Mayıs University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, University of Health Sciences, School of Medicine, Samsun Training and Research Hospital, Department of Endocrinology and Metabolism, Turkey, Gaziosmanpasa University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Hitit University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Giresun University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Recep Tayyip Erdogan University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Karadeniz Technical University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Bulent Ecevit University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Kars Harakani State Hospital, Department of Endocrinology and Metabolism, Turkey, Inonu University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Erzincan University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Yuzuncu Yil University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Harran University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Dicle University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, University of Health Sciences, School of Medicine, Gaziantep Ersin Arslan Research and Training Hospital, Turkey, Gaziantep University, School of Medicine, Department of Endocrinology and Metabolism, Turkey, Çukurova Üniversitesi, Ege Üniversitesi, Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı, TOBB ETÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Demirbaş, Berrin, Zonguldak Bülent Ecevit Üniversitesi, Hitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Salman, Serpil, and Ondokuz Mayıs Üniversitesi
- Subjects
Blood Glucose ,Male ,obesity ,Glycated Hemoglobin A ,Turkey ,Turkish ,blood pressure measurement ,Endocrinology, Diabetes and Metabolism ,Type 2 diabetes ,Disease ,030204 cardiovascular system & hematology ,low density lipoprotein cholesterol ,0302 clinical medicine ,Endocrinology ,high density lipoprotein cholesterol ,Surveys and Questionnaires ,middle aged ,Medicine ,LDL-cholesterol ,glucose ,hemoglobin A1c ,education ,anthropometry ,exercise ,non insulin dependent diabetes mellitus ,adult ,clinical trial ,General Medicine ,health survey ,Europe ,female ,Type 1 diabetes ,risk factor ,diabetes mellitus ,language ,triacylglycerol ,medicine.medical_specialty ,insulin ,metabolic parameters ,hypertension ,HbA1c ,high performance liquid chromatography ,prevalence ,030209 endocrinology & metabolism ,immunoturbidimetry ,insulin dependent diabetes mellitus ,Article ,smoking ,03 medical and health sciences ,blood ,turkey (bird) ,Diabetes mellitus ,Internal medicine ,enzyme chemistry ,Internal Medicine ,cross-sectional study ,Humans ,controlled study ,human ,Glycemic ,glycosylated hemoglobin ,Glycated Hemoglobin ,business.industry ,questionnaire ,dyslipidemia ,medicine.disease ,major clinical study ,language.human_language ,body mass ,Blood pressure ,hypoglycemia ,glucose blood level ,multicenter study ,Cross-Sectional Studies ,Diabetes Mellitus, Type 2 ,Metabolic control analysis ,glycemic control ,Arterial blood pressure ,business ,metabolism - Abstract
Tutuncu, Neslihan Bascil/0000-0002-1816-3903; Gonen, Mustafa Sait/0000-0002-1089-623X; CORAPCIOGLU, DEMET/0000-0003-0940-9147; Satman, Ilhan/0000-0001-8613-1797; nuhoglu, irfan/0000-0003-0650-3242; Sahin, Ibrahim/0000-0002-6231-0034; Demirci, Ibrahim/0000-0003-0498-3115; Altuntas, Seher Cetinkaya/0000-0002-9733-9443; Yildiz, Bulent O./0000-0003-1797-7662; BALCI, Mustafa Kemal/0000-0002-6494-3249; Araz, Mustafa/0000-0001-6741-7474; Saydam, Basak Ozgen/0000-0001-9457-8919; Bozkus, Yusuf/0000-0002-6976-6659; Sabuncu, Tevfik/0000-0001-6504-5355; SELEK, ALEV/0000-0002-0646-8697; Ozturk, Feyza Yener/0000-0001-5584-4954; Salman, Serpil/0000-0003-4867-3725; AKBAS, EMIN MURAT/0000-0002-3033-0073; KIRIK, Ali Murat/0000-0002-5771-4843; Sonmez, Alper/0000-0002-9309-7715; Cesur, Fazil Mustafa/0000-0002-1029-2604, WOS:000452704800016, PubMed: 30244051, Aims: Turkey has the highest prevalence of diabetes in Europe. It is therefore essential to know the overall cardiovascular risk and reveal the predictors of metabolic control in Turkish adults with diabetes mellitus. Methods: A nationwide, multicenter survey consecutively enrolled patients who were under follow up for at least a year. Optimal control was defined as HbA1c, Turkish Society of Endocrinology and Metabolism, The TEMD study has been funded by the Turkish Society of Endocrinology and Metabolism. Automated blood pressure monitors were provided by Sanovel A/S. The funding agencies had no role in the design and conduct of the study; the collection, management, analysis and interpretation of the data; or the preparation, review or approval of the manuscript.
- Published
- 2018
18. The Experience of Transition from Childhood to Adulthood in Endocrinology
- Author
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Esin Karakilic Ozturan, Aslı Derya Kardelen, Ayse Pınar Öztürk, Ayse Kubat Uzum, Mustafa Özçetin, Firdevs Bas, Sukran Poyrazoglu, Nevin Dinccag, Refik Tanakol, Ilhan Satman, and Feyza Darendeliler
- Subjects
Gynecology ,medicine.medical_specialty ,Chronic disease ,business.industry ,medicine ,business - Published
- 2018
19. The prevalence of folate deficiency in the adult population in Turkey: The association with prediabetes and diabetes
- Author
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Kubilay Karsidag, Ilhan Satman, Fulya Turker, Beyhan Omer, Aysegul Telci, Yildiz Tutuncu, Sema Genc, Nevin Dinccag, and Temel Yilmaz
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,Diabetes mellitus ,Biochemistry (medical) ,Clinical Biochemistry ,Adult population ,medicine ,General Medicine ,Prediabetes ,business ,medicine.disease ,Biochemistry - Published
- 2019
20. Does music effect the stress of daily life?
- Author
-
Coskun Oruc, Cengizhan Sonmez, Sevim Oncul, Nevin Dinccag, and Sevda Ozel Yildiz
- Subjects
Stress (mechanics) ,Psychology ,Clinical psychology - Published
- 2017
21. The Relation Of Oxidative Stress Biomarkers With Proinflammatory Cytokines In Gestational Diabetes
- Author
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Sema Genc, Figen Gurdol, Nevin Dinccag, Zeynep Kusku-Kiraz, Nida Oztop, and Elmire Dervisoglu
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Antioxidant ,endocrine system diseases ,business.industry ,medicine.medical_treatment ,General Medicine ,Malondialdehyde ,medicine.disease ,medicine.disease_cause ,Proinflammatory cytokine ,Gestational diabetes ,03 medical and health sciences ,chemistry.chemical_compound ,Antioxidant capacity ,030104 developmental biology ,Endocrinology ,chemistry ,Internal medicine ,medicine ,Glucose homeostasis ,Tumor necrosis factor alpha ,business ,Oxidative stress - Abstract
Background: It has been shown that the synthesis and secretion of cytokines is influenced by the imbalance in oxidant/antioxidant status. In this study, the relation between the circulating levels of oxidative stress biomarkers and proinflammatory cytokines was searched in gestational diabetes mellitus (GDM) patients in order to evaluate the possible role of oxidative stress in ongoing proinflammatory condition and impaired glucose homeostasis. Methods and findings: 33 pregnant women with GDM and 20 pregnant free of any maternal or fetal disorders were included in the study. Visfatin, TNF-α, IL-1β, IL-6, IL-10 and anti-ox-LDL levels were determined by ELISA. Malondialdehyde (MDA) levels and total antioxidant status (TOS) were measured spectrophotometrically. In the GDM group, MDA levels were significantly elevated (p=0.001), while the increment in TOS showed a borderline significance (p=0.05) as compared to the control group. Anti-ox-LDL of both groups remained unchanged. Serum IL-6 and IL-1β were significantly high (p=0.039, and p=0.04) in the GDM group, visfatin and IL-10 were similar in both groups. Slight but no significant increases in TNF-α levels were observed. TNF-α was associated with anti-ox-LDL (r=0.307, p=0.038) and HbA1c (r=0.352, p=0.05), MDA were correlated with TNF-α (r=0.420, p=0.004), TNF-α /IL-1β ratio (r=0.421, p=0.018), and with HbA1c (r=442, p=0.013). Anti-ox-LDL was correlated with TNF-α /IL-10 ratio (r=-0.361, p=0.046). Conclusion: Our results indicated that MDA and TOS levels are elevated in close association with hyperglycemia and some proinflammatory cytokines in GDM patients. According to our study, reestablishment of the oxidant/antioxidant balance should be considered as one of the main therapeutic targets in order to establish normoglycemia as well as to outweigh the inflammatory state in GDM.
- Published
- 2017
22. HDL-C levels in newly diagnosed type 2 diabetes in Turkey
- Author
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Ilhan Satman, Ayse Kubat Uzum, Ahmet Ekmekçi, Nevin Dinccag, Kubilay Karsidag, Gonca Tamer, Murat Mertoglu, and Meral Mert
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Traditional medicine ,Turkish ,business.industry ,Endocrinology, Diabetes and Metabolism ,social sciences ,Newly diagnosed ,Type 2 diabetes ,medicine.disease ,eye diseases ,language.human_language ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,language ,population characteristics ,Risk factor ,business ,geographic locations - Abstract
In this study, we aimed to investigate whether HDL-C levels of non-diabetic and type 2 diabetic Turks are as low as those of non-diabetic Turks reported in Turkish Heart Study (THS) and Turkish Adult Risk Factor Sudy (TEKHARF).
- Published
- 2014
23. Lower urinary tract symptoms in diabetic women with and without urinary incontinence
- Author
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Nezihe Kizilkaya Beji, Selda Celik, Nevin Dinccag, Sema Yilmaz, Meltem Demirgöz Bal, and Onay Yalcin
- Subjects
Related factors ,Gynecology ,medicine.medical_specialty ,Nursing (miscellaneous) ,business.industry ,Urology ,Significant difference ,Urinary incontinence ,medicine.disease_cause ,medicine.disease ,Vaginal Itching ,Female lower urinary tract ,Nephrology ,Lower urinary tract symptoms ,Diabetes mellitus ,Internal medicine ,medicine ,medicine.symptom ,business ,Vaginal infections - Abstract
Determination of lower urinary tract symptoms (LUTS) in diabetic women with and without urinary incontinence (UI) and its related factors is significant to define essential measures associated with prevention. The aim of this study is to compare the features of diabetes mellitus (DM) in diabetic women with and without UI, and to investigate LUTS and its related factors. Applying to the Diabetes Department of Istanbul Medical Faculty, Istanbul University (IMFIU) between May and December 2011, 77 diabetic women with the complaint of UI and 88 diabetic continent women were enrolled into the descriptive study. Data were collected via a questionnaire defining socio-demographic and clinical features, and The Bristol Female Lower Urinary Tract Symptoms (BFLUTS-SF) after obtaining an approval from the ethical board of the institution. It was found that diabetic continent women and those with UI showed no statistically significant difference regarding age, BMI and duration of DM (p > 0·05). Among women with UI, levels of fasting blood glucose and HbA1c were significantly higher (p
- Published
- 2014
24. Role of Low-Level Laser Therapy as an Adjunct to Initial Periodontal Treatment in Type 2 Diabetic Patients: A Split-Mouth, Randomized, Controlled Clinical Trial
- Author
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Oya Demirturk-Gocgun, Nevin Dinccag, Halim Issever, Funda Yalcin, Gokce Aykol-Sahin, and Ulku Baser
- Subjects
Adult ,Male ,medicine.medical_specialty ,Gingival and periodontal pocket ,medicine.medical_treatment ,Bleeding on probing ,Biomedical Engineering ,Dentistry ,Risk Assessment ,Statistics, Nonparametric ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Scaling and root planing ,Reference Values ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Low-Level Light Therapy ,Low level laser therapy ,business.industry ,Dental Plaque Index ,Type 2 Diabetes Mellitus ,030206 dentistry ,Periodontology ,Middle Aged ,medicine.disease ,Chronic periodontitis ,Combined Modality Therapy ,Surgery ,Clinical trial ,Treatment Outcome ,Debridement ,Diabetes Mellitus, Type 2 ,Chronic Periodontitis ,Dental Scaling ,Female ,Patient Safety ,medicine.symptom ,business - Abstract
In this split-mouth clinical trial, we evaluated the clinical benefits of low-level laser therapy (LLLT) as an adjunct to nonsurgical periodontal treatment in patients with type 2 diabetes mellitus (DM).The impaired wound healing seen in diabetic patients may affect the results of periodontal treatment and may require an additional approach.In total, 22 chronic periodontitis patients with type 2 DM were included. Applying a split-mouth design, two quadrants were treated with only scaling and root planing (SRP) as the control and those in the other two were treated with SRP + LLLT as the test sites in each patient. An 808 nm GaAlAs diode laser was performed in the test sites at the energy density of 4.46 J/cmTest sites showed significant improvement in PI and BOP in deep pockets at the 1-month follow-up period (p 0.001 and0.001, respectively), whereas no difference was found between the control and the test sites in other periodontal parameters.LLLT during periodontal treatment offered minimal short-term additional benefit in deep pocket healing in patients with type 2 DM.
- Published
- 2016
25. Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults
- Author
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Bülent Canbaz, Temel Yilmaz, Fulya Turker, Ilhan Satman, Nevin Dinccag, Bekir Cakir, Sema Genc, Kubilay Karsidag, Aysegul Telci, Jaakko Tuomilehto, Beyhan Omer, Yildiz Tutuncu, Sibel Kalaça, and Selda Gedik
- Subjects
Gerontology ,Blood Glucose ,Male ,Rural Population ,Pediatrics ,Turkey ,Urban Population ,Cross-sectional study ,Epidemiology ,Body Mass Index ,Impaired glucose tolerance ,0302 clinical medicine ,Risk Factors ,Prevalence ,030212 general & internal medicine ,Prediabetes ,2. Zero hunger ,education.field_of_study ,Middle Aged ,Impaired fasting glucose ,3. Good health ,Population Surveillance ,Hypertension ,Female ,Adult ,medicine.medical_specialty ,Population ,030209 endocrinology & metabolism ,Prediabetic State ,03 medical and health sciences ,Young Adult ,Diabetes mellitus ,medicine ,Diabetes Mellitus ,Humans ,Obesity ,Sex Distribution ,education ,Aged ,business.industry ,Clinical epidemiology ,Glucose Tolerance Test ,medicine.disease ,Health Surveys ,Cross-Sectional Studies ,Socioeconomic Factors ,business ,Body mass index - Abstract
There is concern about an emerging diabetes epidemic in Turkey. We aimed to determine the prevalence of diagnosed and undiagnosed diabetes, prediabetes and their 12-year trends and to identify risk factors for diabetes in the adult Turkish population. A cross-sectional, population-based survey, ‘TURDEP-II’ included 26,499 randomly sampled adults aged ≥ 20 years (response rate: 87 %). Fasting glucose and biochemical parameters were measured in all; then a OGTT was performed to identify diabetes and prediabetes in eligible participants. The prevalence of diabetes was 16.5 % (new 7.5 %), translating to 6.5 million adults with diabetes in Turkey. It was higher in women than men (p = 0.008). The age-standardized prevalence to the TURDEP-I population (performed in 1997–98) was 13.7 % (if same diagnostic definition was applied diabetes prevalence is calculated 11.4 %). The prevalence of isolated-IFG and impaired glucose tolerance (IGT), and combined prediabetes was 14.7, 7.9, and 8.2 %, respectively; and that of obesity 36 % and hypertension 31.4 %. Compared to TURDEP-I; the rate of increase for diabetes: 90 %, IGT: 106 %, obesity: 40 % and central obesity: 35 %, but hypertension decreased by 11 % during the last 12 years. In women age, waist, body mass index (BMI), hypertension, low education, and living environment; in men age, BMI, and hypertension were independently associated with an increased prevalence of diabetes. In women current smoking, and in men being single were associated with a reduced risk. These results from one of the largest nationally representative surveys carried out so far show that diabetes has rapidly become a major public health challenge in Turkey. The figures are alarming and underscore the urgent need for national programs to prevent diabetes, to manage the illness and thus prevent complications. Electronic supplementary material The online version of this article (doi:10.1007/s10654-013-9771-5) contains supplementary material, which is available to authorized users.
- Published
- 2013
26. Diabetes and cognitive impairment
- Author
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Ilhan Satman, Sibel Cakir, Birsu Beser, Nevin Dinccag, Sukriye Akca Kalem, Seher Tanrikulu, Cemile Idiz, and Gulin Alkan
- Subjects
business.industry ,Diabetes mellitus ,medicine ,Cognitive impairment ,medicine.disease ,business ,Clinical psychology - Published
- 2016
27. How changed face of gestational diabetes mellitus within 12 years in Turkey
- Author
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Sevda Ozel, Fulya Turker, Hulya Hacisahinoglu, Seher Tanrikulu, Nevin Dinccag, Cemile Idiz, Ayse Kubat Uzum, Selda Gedik, Sakin Tekin, and Nurdan Gul
- Subjects
Gestational diabetes ,Pediatrics ,medicine.medical_specialty ,business.industry ,medicine ,Face (sociological concept) ,medicine.disease ,business - Published
- 2016
28. Dimethylarginines in patients with type 2 diabetes mellitus: Relation with the glycaemic control
- Author
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Ayten Can, Yildiz Tutuncu, Nevin Dinccag, Yesim Unlucerci, Seldag Bekpinar, and Figen Gurdol
- Subjects
Blood Glucose ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Type 2 diabetes ,Arginine ,Diabetes Complications ,chemistry.chemical_compound ,Endocrinology ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,Humans ,In patient ,Glycated Hemoglobin ,business.industry ,Case-control study ,Type 2 Diabetes Mellitus ,General Medicine ,Plasma levels ,Prognosis ,medicine.disease ,Glycemic index ,Diabetes Mellitus, Type 2 ,chemistry ,Glycemic Index ,Case-Control Studies ,Female ,business ,Asymmetric dimethylarginine - Abstract
We tested the relationship between plasma levels of dimethylarginines (ADMA and SDMA) and glycaemic control in 43 type 2 diabetic patients. Type 2 diabetics with poor glycaemic control (HbA1c>6.5) had significantly lower SDMA and higher ADMA concentrations than those with well-controlled glycaemia (HbA1c
- Published
- 2011
29. Effect of acute maximal exercise on lymphocyte subgroups in type 1 diabetes
- Author
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Gaye Erten, S Salman, Bayram Kiran, Fatih Salman, Mehmet Ünal, A Kayserilioglu, Yilmaz Mt, Günnur Deniz, and Nevin Dinccag
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,CD3 Complex ,CD8 Antigens ,Antigens, CD19 ,CD4-CD8 Ratio ,Running ,Bruce protocol ,Physiology (medical) ,Internal medicine ,Diabetes mellitus ,Humans ,Outpatient clinic ,Medicine ,Aerobic exercise ,Medical nutrition therapy ,Treadmill ,Exercise ,Type 1 diabetes ,Receptors, IgE ,business.industry ,General Medicine ,medicine.disease ,Lymphocyte Subsets ,Exercise Therapy ,Killer Cells, Natural ,Diabetes Mellitus, Type 1 ,Case-Control Studies ,Metabolic control analysis ,Immunology ,Exercise Test ,Physical Endurance ,business - Abstract
The essential therapy of diabetes mellitus includes medical nutrition therapy (MNT), exercise and medical therapy. Exercise, besides its metabolic effects, has positive influence on the immune system, but some forms of exercise may cause trauma for muscle and skeletal systems, they may also support negative effects on the immune system. Nineteen type 1 diabetic patients (mean age 22.1 +/- 2.8 yrs), followed by Diabetes Outpatient Clinic and twenty age matched male control subjects were included into the study, to demonstrate the effects of maximal, acute exercise on the immune system. The exercise test was performed according to Bruce protocol on treadmill. In diabetic subjects, increased CD19 and CD23 expressions were observed before exercise. In both groups (diabetic/control) CD3, CD4 expressions and CD4/CD8 ratio were decreased following the exercise, however expression of natural killer (NK) cells increased. Compared to type 1 diabetic patients healthy subjects had longer acute exercise that caused the increased level of CD8 expression, however type 1 diabetic patients did not show any difference. These results indicate that submaximal aerobic exercise might be recommended for type 1 diabetics without any complications because of its positive reflection on metabolic control and no negative effects on the immune system.
- Published
- 2008
30. Glycaemic variability in pregnant women with gestational diabetes
- Author
-
Ilhan Satman, Yildiz Tutuncu, Selda Celik, Nida Oztop, Cemile Idiz, Ayse Kubat Uzum, Nevin Dinccag, and Elif Bagdemir
- Subjects
Gestational diabetes ,medicine.medical_specialty ,business.industry ,Obstetrics ,medicine ,medicine.disease ,business - Published
- 2015
31. The risk of future IRS among women with history of gestational diabetes
- Author
-
Bülent Canbaz, Sevda Ozel Yildiz, Selda Gedik, Nevin Dinccag, Yuldiz Tutuncu, and Cemile Idiz
- Subjects
Gestational diabetes ,medicine.medical_specialty ,Obstetrics ,business.industry ,medicine ,medicine.disease ,business - Published
- 2015
32. Risks of having gestational diabetes in the future for mothers and their offspring
- Author
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Sevda Ozel Yildiz, Bülent Canbaz, Selda Gedik, Firdevs Bas, Cemile Idiz, Nevin Dinccag, Sabin Goktas Aydin, Ayse Kubat Uzum, Rüveyde Bundak, and Banu Kucukemre Aydin
- Subjects
Gestational diabetes ,medicine.medical_specialty ,business.industry ,Obstetrics ,Offspring ,medicine ,medicine.disease ,business - Published
- 2015
33. Periodontal Health, Salivary Status, and Metabolic Control in Children with Type 1 Diabetes Mellitus
- Author
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Bora Guvener, Elif Sepet, Gamze Aren, Nevin Dinccag, Erhan Firatli, and Didem Ozdemir
- Subjects
Blood Glucose ,medicine.medical_specialty ,Saliva ,Bleeding on probing ,Gastroenterology ,Statistics, Nonparametric ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,Periodontal Probing ,Child ,Periodontal Diseases ,Type 1 diabetes ,business.industry ,Dental Plaque Index ,Periodontium ,Hydrogen-Ion Concentration ,medicine.disease ,Diabetes Mellitus, Type 1 ,Endocrinology ,Peroxidases ,Case-Control Studies ,Metabolic control analysis ,Chronic Disease ,Correlation analysis ,Periodontics ,Periodontal Index ,medicine.symptom ,business - Abstract
The aim of this study was to determine whether detectable periodontal destruction and alterations in the salivary status were present with duration of diabetes in children with type 1 insulin-dependent diabetes mellitus (type 1 DM) as compared to healthy controls.Sixteen newly diagnosed children with DM (group 1), 16 children with type 1 DM of long duration (group 2), and 16 healthy children (group 3) participated in the study. Periodontal health was assessed by plaque index, gingival index, bleeding on probing, and periodontal probing depths. The flow rate, pH, buffering capacity, and peroxidase activities of stimulated saliva were determined. The data were analyzed by Kruskall-Wallis, Student t test, and Pearson's correlation analysis.The mean values for fasting blood glucose levels for the diabetic groups were significantly higher than for the controls. The mean values for salivary buffering capacities and salivary pH from the diabetic groups were significantly lower than for the controls. The plaque index values for the diabetic groups were significantly higher than for the controls. The mean gingival index value for group 1 was significantly lower than for group 2. The mean periodontal probing depths for group 1 were similar to those of the non-DM controls, but the mean periodontal probing depths for group 2 were significantly greater than for both the non-DM controls and group 1. Group 1 had significantly greater bleeding on probing scores than did the other groups (P0.05).The glycemic status of the diabetic subjects affects the periodontal probing depths, salivary pH, buffering capacity, and peroxidase activity.
- Published
- 2003
34. Population-Based Study of Diabetes and Risk Characteristics in Turkey
- Author
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Fatih Salman, Hilary King, Sevil Uygur, Yildiz Tutuncu, Ilhan Satman, Mehmet Sargin, Sibel Kalaça, Irfan Bastar, Kubilay Karsidag, Serpil Salman, Nevin Dinccag, Ahmet Sengul, Cihangir Ozcan, and Temel Yilmaz
- Subjects
Advanced and Specialized Nursing ,Research design ,medicine.medical_specialty ,education.field_of_study ,endocrine system diseases ,business.industry ,Endocrinology, Diabetes and Metabolism ,Public health ,Population ,nutritional and metabolic diseases ,medicine.disease ,Obesity ,Impaired glucose tolerance ,Endocrinology ,Internal medicine ,Diabetes mellitus ,Epidemiology ,Internal Medicine ,medicine ,Risk factor ,business ,education ,Demography - Abstract
OBJECTIVES—To investigate for the first time the prevalence of diabetes and impaired glucose tolerance (IGT) nationwide in Turkey; to assess regional variations and relationships between glucose intolerance and lifestyle and physical risk factors. RESEARCH DESIGN AND METHODS—The Turkish Diabetes Epidemiology Study (TURDEP) is a cross-sectional, population-based survey that included 24,788 subjects (age ≥20 years, women 55%, response 85%). Glucose tolerance was classified according to World Health Organization recommendations on the basis of 2-h blood glucose values. RESULTS—Crude prevalence of diabetes was 7.2% (previously undiagnosed, 2.3%) and of IGT, 6.7% (age-standardized to world and European populations, 7.9 and 7.0%). Both were more frequent in women than men (P < 0.0001) and in those living in urban rather than rural communities (P < 0.001). Prevalence rates of hypertension and obesity were 29 and 22%, respectively. Both were more common among women than men (P < 0.0001). Prevalence of diabetes and IGT increased with rising BMI, waist-to-hip ratio (WHR), and waist girth (P < 0.0001). Multiple logistic regression analysis revealed that age, BMI, WHR, familial diabetes, and hypertension were independently associated with diabetes, age, BMI, WHR, familial diabetes, and hypertension with IGT (except for familial diabetes in women with IGT). Education was related to diabetes in men but was protective for diabetes and IGT in women. Socioeconomic status appeared to decrease the risk of IGT in men while it increased the risk in women. Smoking had a protective effect for IGT in both sexes. CONCLUSIONS—Diabetes and IGT are moderately common in Turkey by international standards. Associations with obesity and hypertension have been confirmed. Other lifestyle factors had a variable relationship with glucose tolerance.
- Published
- 2002
35. Evaluation of insulin resistant diabetes mellitus in Alström syndrome: a long-term prospective follow-up of three siblings
- Author
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Nevin Dinccag, A Ökten, T Ovalı, S Karadeniz, Mustafa Yilmaz, N Gürsoy, Zehra Bugra, V Uysal, Ilhan Satman, S Devrim, and Kubilay Karsidag
- Subjects
Adult ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Turkey ,Diabetic ketoacidosis ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Short stature ,Diabetic Ketoacidosis ,Nuclear Family ,Endocrinology ,Insulin resistance ,Diabetes mellitus ,Internal medicine ,Diabetes Mellitus ,Internal Medicine ,medicine ,Humans ,Abnormalities, Multiple ,Child ,business.industry ,Insulin ,Fatty liver ,General Medicine ,medicine.disease ,Obesity ,Pedigree ,Female ,Insulin Resistance ,medicine.symptom ,business ,Alström syndrome - Abstract
Alstrom syndrome is a rare cause of diabetes mellitus. We studied two generations of a Turkish family in whom four members were affected by Alstrom syndrome. The natural course of the syndrome in three sisters was followed for 13 yr. The three sisters had short stature and truncal obesity, and developed complete blindness due to retinitis pigmentosa at 10, 5 and 13 yr of age. Two had sensorineural hearing loss and mild mental retardation, while the other developed diabetic ketoacidosis (DKA) at 14 yr and was treated with insulin from onset of diabetes. In the second case, diagnosis of diabetes was made by an OGTT at age 20 yr, and controlled with diet alone for 11 yr, then with a sulphonylurea for 2.5 yr, then with insulin. The third case developed acute hyperglycaemia at 20 yr, and required insulin from onset. Moreover, transitional features of impaired carbohydrate and fat metabolism (severe hyperinsulinaemia and insulin resistance progressing to islet β cell failure, and hypertriglyceridaemia with fatty liver) were demonstrated, in accord with the literature. Previously unreported findings characteristic of nephro-uropathy with early-onset hypertension were also detected, and included in all cases proteinuria, glomerulopathy, and abnormal locations of the kidneys, narrowed uretero–renal junctions and dilated ureters.
- Published
- 2002
36. Immunoprotection in spontaneous remission of type 1 diabetes: long-term follow-up results
- Author
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Fikret Biyal, Elif Arioǧlu, Kubilay Karsidag, A.Sevim Devrim, Nevin Dinccag, M. Temel Yilmaz, Gunseli Yilmaz, İlgin Özden, Ilhan Satman, Nuray Gürel, and Fikret Sipahioǧlu
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.drug_class ,T-Lymphocytes ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Remission, Spontaneous ,Pilot Projects ,Spontaneous remission ,Placebo ,Methylprednisolone ,Gastroenterology ,Drug Administration Schedule ,law.invention ,Islets of Langerhans ,Endocrinology ,Randomized controlled trial ,law ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,Prospective Studies ,Autoantibodies ,Glycated Hemoglobin ,Type 1 diabetes ,C-Peptide ,business.industry ,Insulin ,Histocompatibility Antigens Class II ,HLA-DR Antigens ,General Medicine ,medicine.disease ,Surgery ,Diabetes Mellitus, Type 1 ,Basal (medicine) ,Corticosteroid ,Female ,business ,Follow-Up Studies - Abstract
This prospective pilot study was undertaken to test the efficacy of oral methyl-prednisolone (MP) therapy at spontaneous remission phase of type 1 diabetes in intervening the course of the disease. Twenty-five type 1 diabetic patients who were classified as having a spontaneous remission (honeymoon) were divided into treatment and non-treatment groups on voluntary basis. Fifteen patients thus making up the treatment group (13 males and 2 females, mean age 23.8 +/- 6.2 years) received 0.7-1.0 mg/kg/day of MP p.o. for 2 weeks. The dose of the drug was then gradually diminished every week until 5 mg/day (approx. 0.1 mg/kg/day) and discontinued at 10 +/- 2 weeks. In case of hyperglycemia occurring in 12 of 15 patients due to the administration of steroid, insulin was used to normalize blood glucose levels (average 0.47 +/- 0.21 IU/kg/day). The non-treatment group (8 males and 2 females, mean age 21.8 +/- 8.9) did not receive any special medication or placebo except for insulin whenever necessary to regulate glycemia. Upon completion of protocol, all patients in treatment group displayed clinical remission with 10 still in non-insulin requiring remission for follow-up periods ranging between 16 and 91 months. The remaining 5 patients relapsed within 3-15 months of therapy. Other metabolic (including basal and stimulated C-peptide levels) and immunological indices that have spontaneously ameliorated with the occurrence of honeymoon were also maintained within normal range in the NIR patients. Meanwhile, natural remission in the non-MP-treated group terminated at 3.4 +/- 0.6 months with deterioration of all metabolic and immunological markers as well as increasing requirements for insulin. In conclusion, the spontaneous remission of the patients could be prolonged significantly by MP therapy as opposed to no therapy (P0.001). These results suggest that the spontaneous remission phase may be a crucial point of intervention in immunotherapy of type 1 diabetes and that randomized trials with MP at this particular phase would be worthwhile.
- Published
- 1993
37. Salivary peroxidase activity in whole saliva of patients with insulin-dependent (type-1) diabetes mellitus
- Author
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Nevin Dinccag, Ilhan Satman, Y Güven, and S Alptekin
- Subjects
Adult ,medicine.medical_specialty ,Plaque index ,Adolescent ,Internal medicine ,Diabetes mellitus ,Humans ,Periodontal Pocket ,Medicine ,Salivary Proteins and Peptides ,Whole saliva ,Periodontitis ,Saliva ,Type 1 diabetes ,business.industry ,Dental Plaque Index ,Healthy subjects ,medicine.disease ,Diabetes Mellitus, Type 1 ,Endocrinology ,Peroxidases ,Spectrophotometry ,Periodontics ,Periodontal Index ,Gingival Hemorrhage ,business ,Insulin dependent ,Biomarkers ,Salivary peroxidase - Abstract
In this study, salivary peroxidase activity was measured in a group of 10 patients with insulin-dependent (type I) diabetes mellitus (IDDM) who had a tendency towards periodontitis. In healthy subjects (N : 10), mean salivary peroxidase activity was 0.0025 +/- 0.001 IU/ml, while in this group of type I diabetic patients it was 0.051 +/- 0.015 IU/ml, a significantly higher level (p < 0.001). Approximal plaque index (API), modified sulcus bleeding index (mod SBI) and pocket depths were assessed clinically. The values for mod SBI and API were 60% and 68% respectively for the diabetic patients while for the control group mod SBI was measured 0.0% and the value for API was 10.67% (p < 0.001). The administration of this simple and practical test may provide an early marker of a tendency towards periodontitis in IDDM patients.
- Published
- 1996
38. Alstrom syndrome: a case report
- Author
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Nevin Dinccag, Yasemin Benderli, Ilhan Satman, Can Dörter, Kubilay Karsidag, Temel Yilmaz, and Fatma Koray
- Subjects
Adult ,Pathology ,medicine.medical_specialty ,Adolescent ,Hearing loss ,Hearing Loss, Sensorineural ,Short stature ,Diabetes Complications ,Gingivitis ,Consanguinity ,medicine ,Humans ,Abnormalities, Multiple ,Obesity ,General Dentistry ,Pathological ,Anterior teeth ,business.industry ,Retinal Degeneration ,Syndrome ,Enamel hypoplasia ,medicine.disease ,stomatognathic diseases ,medicine.anatomical_structure ,Basal lamina ,Dental Enamel Hypoplasia ,Female ,Kidney Diseases ,medicine.symptom ,business ,Alström syndrome - Abstract
Alstrom syndrome is a rare disorder characterized by early obesity, loss of central vision, diabetes mellitus, hearing loss and short stature. Previous studies, have reported no information regarding oral findings. This article describes oral findings in two cases of Alstrom syndrome. In both cases, gingivitis was present and also light yellowbrown discolored enamel bands were observed on the anterior teeth. This staining may have resulted from discoloration of the preexisting slight band-like enamel hypoplasia. The gingiva was examined histologically by light and transmission electron microscopy. Irregular thickness of the basal lamina and delamination of the myelin sheath were detected by transmission electron microscopy. There is no information about pathological odontogenesis in Alstrom syndrome in previous reports. Oral present findings may contribute further information about the clinical manifestations of Alstrom syndrome. (J. Oral Sci. 43, 221-224, 2001)
- Published
- 2001
39. Comparison of acarbose and gliclazide as first-line agents in patients with type 2 diabetes
- Author
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Mustafa Yilmaz, Fatih Salman, Ahmet Sengul, Ilhan Satman, Emel Özer, H O Demirel, Serpil Salman, Yücel Yilmaz, Nevin Dinccag, and Kubilay Karsidag
- Subjects
Blood Glucose ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Type 2 diabetes ,Gastroenterology ,Internal medicine ,Diabetes mellitus ,Diet, Diabetic ,medicine ,Humans ,Hypoglycemic Agents ,Insulin ,Gliclazide ,Glycoside Hydrolase Inhibitors ,Medical nutrition therapy ,Acarbose ,Aged ,Glycated Hemoglobin ,business.industry ,General Medicine ,Fasting ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Diabetic diet ,Endocrinology ,Postprandial ,Treatment Outcome ,Diabetes Mellitus, Type 2 ,Female ,business ,medicine.drug - Abstract
To compare the effect of acarbose and gliclazide on clinical findings, biochemical parameters and safety in type 2 diabetic patients insufficiently controlled with medical nutrition therapy (MNT).Seventy-two patients (age 35-70 years, BMIor = 35 kg/m2), who had not taken any oral antidiabetic drug previously, were randomised into two groups after a four-week placebo period, and treated for 24 weeks with acarbose (100 mg two to three times daily) and gliclazide (40-80 mg twice daily). The study was open and 57 patients (33 males and 24 females) completed it. MNT was provided for each patient based on personal requirements as defined by a dietitian. The effect of treatment was evaluated by fasting and postprandial (PP) metabolic parameters (blood glucose, insulin and C peptide levels), HbA1c and plasma lipid levels. In addition, side-effects were recorded and clinical examinations performed.Both drugs were effective in reducing of HbA1c, fasting and PP blood glucose levels. However, PP serum insulin levels in the gliclazide group increased more than those in the group treated with acarbose (p = 0.007). Moreover, a small weight reduction was obtained with acarbose treatment but not with gliclazide. Lipid levels were favourably affected by both drugs. Total cholesterol levels decreased in both groups, the decrease only reaching significance in the acarbose group (p = 0.013). However, serum levels of LDL cholesterol decreased in both groups (acarbose and gliclazide, p = 0.033 and p = 0.023, respectively), but the ratio of HDL to LDL cholesterol increased in the acarbose group only (p = 0.045). Both treatments were generally well tolerated. Common complaints in the acarbose group were flatulence and meteorism (29.6%). However, 10.0% of the patients in the gliclazide group reported at least one mild hypoglycaemic episode.The results of the study demonstrate that acarbose and gliclazide were reasonably effective in improving metabolic control in patients insufficiently controlled with diet alone, and both treatments were well tolerated. Because of its effects on weight reduction and PP hyperinsulinaemia, acarbose may be preferred as a first-line drug, particularly in the treatment of overweight type 2 diabetic patients.
- Published
- 2001
40. Influence of earthquake on the quality of life of patients with type 1 diabetes
- Author
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Ahmet Sengul, Yilmaz Mt, Ilhan Satman, N Gürsoy, Nevin Dinccag, Fatih Salman, Kubilay Karsidag, Şükrü Hatun, Emel Özer, and Serpil Salman
- Subjects
Gerontology ,Psychiatry and Mental health ,Type 1 diabetes ,Neurology ,Quality of life ,business.industry ,General Neuroscience ,medicine ,Neurology (clinical) ,General Medicine ,medicine.disease ,business - Published
- 2001
41. Universal versus ADA approach to diagnosis of gestational diabetes
- Author
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Nevin Dinccag, Faith Salman, Selda Gedik, Rivaze Bulut, Kubilay Karsidag, Temel Yilmaz, Nilgun Gursoy, Serpil Salman, Irfan Bastar, Yücel Yilmaz, and Ilhan Satman
- Subjects
Gestational diabetes ,Pediatrics ,medicine.medical_specialty ,Endocrinology ,business.industry ,Endocrinology, Diabetes and Metabolism ,Diabetes mellitus ,Internal Medicine ,medicine ,General Medicine ,medicine.disease ,business - Published
- 2000
42. Epidemiology of diabetes and obesity in Turkey
- Author
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Irfan Bastar, M Sargin, Nevin Dinccag, Fatih Salman, Sevil Uygur, Yildiz Tutuncu, Kubilay Karsidag, Ahmet Sengul, Cihangir Ozcan, Ilhan Satman, Temel Yilmaz, and Serpil Salman
- Subjects
medicine.medical_specialty ,Pediatrics ,Endocrinology ,business.industry ,Endocrinology, Diabetes and Metabolism ,Diabetes mellitus ,Epidemiology ,Internal Medicine ,medicine ,General Medicine ,medicine.disease ,business ,Obesity - Published
- 2000
43. Alteration of visual function in impaired glucose tolerance
- Author
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Nur Kir, Koray Akarçay, Nevin Dinccag, Ilhan Satman, Devrim As, S Karadeniz, Ercan Öngör, Yilmaz Mt, and Başar D
- Subjects
Male ,medicine.medical_specialty ,genetic structures ,Color vision ,media_common.quotation_subject ,Visual Acuity ,Contrast Sensitivity ,Impaired glucose tolerance ,03 medical and health sciences ,0302 clinical medicine ,Reference Values ,Internal medicine ,Ophthalmology ,Diabetes mellitus ,Glucose Intolerance ,medicine ,Humans ,Contrast (vision) ,media_common ,business.industry ,Vision Tests ,General Medicine ,Diabetic retinopathy ,Middle Aged ,medicine.disease ,eye diseases ,Posterior segment of eyeball ,Low vision ,Endocrinology ,Diabetes Mellitus, Type 2 ,Visual function ,030221 ophthalmology & optometry ,Female ,business ,Color Perception ,030217 neurology & neurosurgery - Abstract
People with impaired glucose tolerance are considered to be prone to diabetes. To evaluate their visual function we investigated colour vision with the Farnsworth-Munsell 100 Hue test and contrast sensitivity with Arden's grating cards in people with impaired glucose tolerance (IGT), people with normal glucose tolerance (NGT) and others with type II diabetes (NIDDM). Eyes with low vision or any anterior or posterior segment abnormalities were excluded. Contrast sensitivity and color vision differed significantly between the groups (p
44. Evaluation of penile arterial system with color Doppler ultrasonography in nondiabetic and diabetic males
- Author
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Kubilay Karsidag, Nevin Dinccag, Ates Kadioglu, Ilhan Satman, T Erdogru, Murat Yilmaz, and S Tellaloğlu
- Subjects
Adult ,Male ,medicine.medical_specialty ,Duplex ultrasonography ,Adolescent ,Urology ,Impotence, Vasculogenic ,Diabetes mellitus ,Internal medicine ,Papaverine ,medicine ,Diabetes Mellitus ,Humans ,Ultrasonography, Doppler, Color ,Aged ,business.industry ,Smoking ,Blood flow ,Arteries ,Middle Aged ,medicine.disease ,Surgery ,Erectile dysfunction ,medicine.anatomical_structure ,Circulatory system ,Cardiology ,business ,Penis ,Blood Flow Velocity ,medicine.drug ,Artery - Abstract
The parameters of the functional evaluation of the penile arterial system in sexually active males are based on a minimal number of volunteers and impotent patients of neurogenic origin who are expected to have a normal vascular system. In order to investigate these parameters in 23 sexually active diabetic and nondiabetic males, penile arterial systems were evaluated by color Doppler ultrasonography. Parameters obtained from the cavernous arteries were arterial diameter (pre- and postpapaverine), diameter increase rate and systolic peak blood flow velocity. Systolic peak blood flow velocities in papaverine-induced erection were 36.75 (+/- 9.99) and 37.50 (+/- 13.18) cm/s for right and left cavernosal arteries, respectively, in nondiabetic 16 men. The mean cavernosal artery diameter changes were 89.23 and 77.93% for right and left cavernosal arteries. Systolic peak blood flow velocities were 24.57 (+/- 7.44) and 25.42 (+/- 9.45) cm/s and diameter increase rates were 78.57 and 37.50% for right and left cavernosal arteries in diabetic sexually active men. Sexually active diabetics have a significantly lower cavernosal artery peak blood flow velocity and diameter increase rate than nondiabetics (p < 0.01). Thus a subclinic dysfunction of erection might be introduced in diabetic males. In conclusion, each investigator should determine his own standards on sexually active subjects and on those with different etiologies such as diabetics mellitus, hypertension and hypercholesterolemia, contributing to erectile dysfunction.
45. Lower Urinary Tract Symptoms in Women With Type 2 Diabetes Mellitus.
- Author
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Dereli Yilmaz S, Demirgoz Bal M, Celik S, Rathfisch G, Kizilkaya Beji N, Dinccag N, and Yalcin O
- Subjects
- Adult, Age Factors, Ambulatory Care Facilities organization & administration, Ambulatory Care Facilities statistics & numerical data, Diabetes Mellitus, Type 2 epidemiology, Diabetes Mellitus, Type 2 physiopathology, Female, Humans, Lower Urinary Tract Symptoms epidemiology, Middle Aged, Prevalence, Risk Factors, Smoking adverse effects, Surveys and Questionnaires, Turkey epidemiology, Urination Disorders epidemiology, Urination Disorders etiology, Diabetes Mellitus, Type 2 complications, Lower Urinary Tract Symptoms etiology
- Abstract
Purpose: The aim of the study was to compare lower urinary tract symptoms (LUTS) in women with and without type 2 diabetes mellitus (DM)., Subjects and Setting: The sample was drawn from community-dwelling women in the province of Istanbul who were cared for in the diabetes outpatient clinic of Istanbul Medical School between January and June 2012. Two hundred forty-nine women with DM were compared to 255 women without DM cared for in the obstetrics and gynecology department of the same university hospital. The mean ages of the groups were 55.1 and 53.7 years, respectively., Methods: Participants completed a questionnaire that queried sociodemographic and clinical characteristics; the Bristol Female Lower Urinary Tract Symptoms-Short Form (BFLUTS-SF) was used to evaluate LUTS. The questionnaire required 10 to 15 minutes to complete; participants completed the questionnaire in a private room of each of the respective outpatient clinics., Results: No statistically significant differences were found when groups (women with and without DM) were compared based on age and cigarette smoking (P > .05). In contrast, BMI scores were significantly higher in the women with DM (P < .001). The cumulative BFLUTS scores and the filling and incontinence symptoms subscale sores (P < .001) were significantly higher in women with DM. No differences were observed in voiding symptoms (P = .347), sexual function (P = .380), and health-related quality of life (P = .142) subscale scores. The prevalence of storage symptoms nocturia, voiding frequency, urge incontinence, stress incontinence, frequency of incontinent episodes were higher among women with DM. In addition, women with DM were more likely to report the need to change clothing because of urinary leakage, effect of incontinence on daily tasks, and overall interference with daily activities of living., Conclusions: Women with type 2 DM are more likely to experience LUTS as compared to women without DM. Women with type 2 DM should routinely be assessed for LUTS.
- Published
- 2016
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