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3. Ventrikuläre Extrasystolen und Breitkomplextachykardien

Author

Berkovitz, Artur, Deneke, Thomas, Ene, Elena, Halbfaß, Philipp, Hebe, Joachim, Hobbiesiefken, Sven, Katus, Hugo A., Konrad, Torsten, Lange, Björn, Marx, Alexandra, Nentwich, Karin, Neuzner, Jörg, Paliege, Robert, Reinhardt, Adrian, Rostock, Thomas, Siebels, Jürgen, Scholz, Eberhard P., and Sonne, Kai

Published
2019
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7. Prospective randomized comparison of durability of bidirectional conduction block in the cavotricuspid isthmus in patients after ablation of common atrial flutter using cryothermy and radiofrequency energy: The CRYOTIP study

Author

Kuniss, Malte, Vogtmann, Thomas, Ventura, Rodolfo, Willems, Stephan, Vogt, Jürgen, Grönefeld, Gerian, Hohnloser, Stefan, Zrenner, Bernhard, Erdogan, Ali, Klein, Gunnar, Lemke, Bernd, Neuzner, Jörg, Neumann, Thomas, Hamm, Christian W., and Pitschner, Heinz-Friedrich

Published
2009
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15. Rate, time course, and predictors of implantable cardioverter defibrillator infections: an analysis from the SIMPLE trial

Author

Philippon, François, O’Hara, Gilles E., Champagne, Jean, Hohnloser, Stefan H., Glikson, Michael, Neuzner, Jörg, Mabo, Philippe, Vinolas, Xavier, Kautzner, Josef, Gadler, Fredrik, Lashevsky, Noa, Connolly, Stuart J., Liu, Yan Y., Healey, Jeff S., Philippon, François, O’Hara, Gilles E., Champagne, Jean, Hohnloser, Stefan H., Glikson, Michael, Neuzner, Jörg, Mabo, Philippe, Vinolas, Xavier, Kautzner, Josef, Gadler, Fredrik, Lashevsky, Noa, Connolly, Stuart J., Liu, Yan Y., and Healey, Jeff S.

Abstract

Background: The number of implantable cardioverter defibrillator (ICD) infections is increasing due to an increased number of ICD implants, higher-risk patients, and more frequent replacement procedures, which carry a higher risk of infection. Reducing the morbidity, mortality, and cost of ICD-related infections requires an understanding of the current rate of this complication and its predictors. Methods: The Shock Implant Evaluation Trial (SIMPLE) trial randomized 2500 ICD recipients to defibrillation testing or not. Over an average of 3.1 years, patients were seen every 6 months and examined for evidence of ICD infection, which was defined as requiring device removal and/or intravenous antibiotics. Results: Within 24 months, 21 patients (0.8%) developed infection. Fourteen patients (67%) with infection presented within 30 days, 20 patients by 12 months, and only 1 patient beyond 12 months. Univariate analysis demonstrated that patients with primary electrical disorders (3 patients, P = 0.009) and those with a secondary prevention indication (13 patients, P = 0.0009) were more likely to develop infection. Among the 2.2% of patients who developed an ICD wound hematoma, 10.4% developed an infection. Among the 8.3% of patients requiring an ICD reintervention, 1.9% developed an infection. Conclusions: This cohort of ICD recipients at high-volume centres have a low risk of device-related infection. However; strategies to reduce wound hematoma and the need for ICD reintervention could further reduce the rate of infection., Contexte: L’incidence des cas d’infection du défibrillateur cardioverteur implantable (DCI) augmente en raison du nombre accru d’implantations, de l’emploi de ces dispositifs chez des patients exposés à un risque très élevé et de l’augmentation de la fréquence des interventions de remplacement, qui sont associées à un plus grand risque d’infections. Pour parvenir à réduire la morbidité, la mortalité et les coûts associés aux infections liées à un DCI, il faut connaître la fréquence de cette complication et les facteurs qui permettent de la prédire. Méthodologie: Lors de l’essai S hock Impl ant E valuation Trial (SIMPLE), 2 500 patients ayant reçu un DCI ont été répartis aléatoirement en deux groupes, l’un subissant des tests de défibrillation et l’autre, non. Sur une période de 3,1 ans en moyenne, les patients ont été vus en consultation tous les 6 mois et examinés à la recherche de signes d’infection du DCI, définie comme étant une infection exigeant le retrait du dispositif et/ou l’administration d’antibiotiques par voie intraveineuse. Résultats: Au total, 21 patients (0,8 %) ont présenté une infection dans les 24 mois suivant l’implantation. Quatorze patients (67 %) ont présenté une infection dans les 30 jours suivant l’intervention; à 12 mois, 20 patients avaient présenté une infection. Un seul patient a présenté une infection plus de 12 mois après l’intervention. Les résultats d’une analyse univariée ont démontré qu’une infection était plus probable chez les patients qui présentaient un trouble électrique primaire (3 patients, p = 0,009) et chez ceux qui avaient reçu un dispositif en prévention secondaire (13 patients, p = 0,0009). Parmi les patients qui présentaient un hématome après l’implantation du DCI (2,2 %), 10,4 % ont présenté une infection. Parmi les patients qui ont eu besoin d’une nouvelle intervention relative au DCI (8,3 %), 1,9 % ont présenté une infection. Conclusions: Les patients de cette cohorte ayant reçu un DCI dans des établissements à haut

Published
2020

22. Rate, Time Course, and Predictors of Implantable Cardioverter Defibrillator Infections: An Analysis From the SIMPLE Trial

Author

Philippon, François, primary, O’Hara, Gilles E., additional, Champagne, Jean, additional, Hohnloser, Stefan H., additional, Glikson, Michael, additional, Neuzner, Jörg, additional, Mabo, Philippe, additional, Vinolas, Xavier, additional, Kautzner, Josef, additional, Gadler, Fredrik, additional, Lashevsky, Noa, additional, Connolly, Stuart J., additional, Liu, Yan Y., additional, and Healey, Jeff S., additional

Published
2020
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25. An Entirely Subcutaneous Implantable Cardioverter-Defibrillator

Author

Bardy, Gust H., Smith, Warren M., Hood, Margaret A., Crozier, Ian G., Melton, Iain C., Jordaens, Luc, Theuns, Dominic, Park, Robert E., Wright, David J., Connelly, Derek T., Fynn, Simon P., Murgatroyd, Francis D., Sperzel, Johannes, Neuzner, Jörg, Spitzer, Stefan G., Ardashev, Andrey V., Oduro, Amo, Boersma, Lucas, Maass, Alexander H., Van Gelder, Isabelle C., Wilde, Arthur A., van Dessel, Pascal F., Knops, Reinoud E., Barr, Craig S., Lupo, Pierpaolo, Cappato, Riccardo, and Grace, Andrew A.

Published
2010
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28. Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial

Author

Schächinger, Volker, Erbs, Sandra, Elsässer, Albrecht, Haberbosch, Werner, Hambrecht, Rainer, Hölschermann, Hans, Yu, Jiangtao, Corti, Roberto, Mathey, Detlef G., Hamm, Christian W., Süselbeck, Tim, Werner, Nikos, Haase, Jürgen, Neuzner, Jörg, Germing, Alfried, Mark, Bernd, Assmus, Birgit, Tonn, Torsten, Dimmeler, Stefanie, and Zeiher, Andreas M.

Published
2006

33. Effectiveness of single‐ vs dual‐coil implantable defibrillator leads: An observational analysis from the SIMPLE study

Author

Neuzner, Jörg, primary, Hohnloser, Stefan H., additional, Kutyifa, Valentina, additional, Glikson, Michael, additional, Dietze, Thomas, additional, Mabo, Philippe, additional, Vinolas, Xavier, additional, Kautzner, Josef, additional, O'Hara, Gilles, additional, Lawo, Thomas, additional, Brachmann, Johannes, additional, VanErven, Liselot, additional, Gadler, Fredrik, additional, Appl, Ursula, additional, Wang, Jia, additional, Connolly, Stuart J., additional, and Healey, Jeff S., additional

Published
2019
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38. Wound haematoma following defibrillator implantation: incidence and predictors in the Shockless Implant Evaluation (SIMPLE) trial

Author

Masiero, Simona, primary, Connolly, Stuart J., additional, Birnie, David, additional, Neuzner, Jörg, additional, Hohnloser, Stefan H., additional, Vinolas, Xavier, additional, Kautzner, Josef, additional, O'Hara, Gilles, additional, VanErven, Lieselot, additional, Gadler, Fredrik, additional, Wang, Jia, additional, Mabo, Philippe, additional, Glikson, Michael, additional, Kutyifa, Valentina, additional, Wright, David J., additional, Essebag, Vidal, additional, and Healey, Jeff S., additional

Published
2016
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42. A randomised comparison of an everolimus-eluting coronary stent with a paclitaxel-eluting coronary stent:the SPIRIT II trial

Author

Serruys, Patrick W., Ruygrok, Peter, Neuzner, Jörg, Piek, Jan J., Seth, Ashok, Schofer, Joachim J., Richardt, Gert, Wiemer, Marcus, Carrié, Didier, Thuesen, Leif, Boone, Els, Miquel-Herbert, Karine, Daemen, Joost, Amsterdam Cardiovascular Sciences, and Cardiology

Subjects
surgical procedures, operative, cardiovascular diseases, equipment and supplies
Abstract

Background: Everolimus has been successfully tested in humans using both an erodable and a durable polymer in small previous studies.Methods: This single blind multi-centre non-inferiority randomised (3:1) controlled trial evaluated the safety and performance of the XIENCE V Everolimus Eluting Coronary Stent System (XIENCE V EECSS) versus the TAXUS Paclitaxel Eluting Coronary Stent System (TAXUS(R) PECSS) in the treatment of patients with a maximum of two de novo native coronary artery lesions located in two different epicardial vessels. Three hundred patients with evidence of myocardial ischaemia were allocated to stent implantation with an everolimus-eluting stent (n=223) or a paclitaxel-eluting stent (n=77). Suitable lesions had a diameter stenosis of

Published
2006

43. Wound haematoma following defibrillator implantation: incidence and predictors in the Shockless Implant Evaluation (SIMPLE) trial.

Author

Masiero, Simona, Connolly, Stuart J., Birnie, David, Neuzner, Jörg, Hohnloser, Stefan H., Vinolas, Xavier, Kautzner, Josef, O'Hara, Gilles, Van Erven, Lieselot, Gadler, Fredrik, Jia Wang, Mabo, Philippe, Glikson, Michael, Kutyifa, Valentina, Wright, David J., Essebag, Vidal, Healey, Jeff S., VanErven, Lieselot, Wang, Jia, and SIMPLE Investigators

Abstract

Aims: Pocket haematoma is a common complication after defibrillator [implantable cardioverter defibrillator (ICD)] implantation, which is not only painful, but also increases the risk of device-related infection, and possibly embolic events. The present study seeks to evaluate the rate and predictors of clinically significant pocket haematoma.Methods and Results: This study included 2500 patients receiving an ICD in the SIMPLE trial. A clinically significant pocket haematoma was defined as a haematoma that required re-operation or interruption of oral anticoagulation (OAC) therapy. Clinically significant pocket haematoma occurred in 56 of 2500 patients (2.2%) of which 6 (10.7%) developed device-related infection. Patients who developed pocket haematoma were older (mean age 67.6 ± 8.8 years vs. 62.7 ± 11.6 years, P < 0.001), were more likely to have permanent atrial fibrillation (30.4 vs. 6.7%, P < 0.001) and a history of stroke (17.9 vs. 6.7%, P = 0.004), or were more likely to receive peri-operative OAC (50.0 vs. 28.4%, P < 0.001), unfractionated heparin (16.1 vs. 5.2%, P = 0.003), or low-molecular-weight heparin (37.5 vs. 17.5%, P < 0.001). Independent predictors of wound haematoma on multivariable analysis included the use of heparin bridging (OR 2.65, 95% CI 1.48-4.73, P = 0.001), sub-pectoral location of ICD (OR 2.00, 95% CI 1.12-3.57, P =0.020), previous stroke (OR 2.47, 95% CI 1.20-5.10, P = 0.015), an upgrade from permanent pacemaker (OR 2.52, 95% CI 1.07-5.94, P = 0.035), and older age (OR 1.03, 95% CI 1.00-1.06, P = 0.049).Conclusion: Pocket haematoma remains an important complication of ICD implantation and is associated with a high risk of infection. Independent predictors of pocket haematoma include heparin bridging, prior stroke, sub-pectoral placement of ICD, older age, and upgrade from a pacemaker. [ABSTRACT FROM AUTHOR]

Published
2017
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