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From internationally renowned expert in resuscitation and New York Times bestselling author Sam Parnia, MD, PhD, comes a groundbreaking look at what happens to us when we die, based on the largest-ever research study run on recalled experiences of death. Today, for the first time in history, the scientific exploration of death and what happens when we die is real, active and ongoing. Contrary to popular perceptions, this subject is no longer the remit of philosophy, religion, or personal opinion. Truly remarkable scientific discoveries that will fundamentally affect everyone's lives now and in the future are taking place, yet very few people are aware of them. Most people—including scientists and doctors—maintain strong beliefs about death and its experience. Those beliefs are rooted in traditional, and often cultural, notions of death. But what if all that we have come to believe about death is fundamentally wrong? What if the paradigm we have been operating within no longer exists? What if death is not the end we thought?Lucid Dying is the first book to share that science. Presenting data derived from multiple groundbreaking studies, Dr. Parnia shows that the entity we refer to as consciousness—our Self—does not seem to become annihilated when we die. In fact, during death, our consciousness vastly expands and leads to a vivid experience that follows a very specific narrative arc. These studies support that there really is a universal experience of death that is meaningful, transcendent, positive, and transformative—not hallucinatory, delusional, or illusory as previously imagined. In his latest book, Dr. Parnia weaves empirical research with gripping stories to show us the truth of how death is not the end we all thought and how anyone can harness the newfound wisdom to lead deeper, more intentional lives.

Neurowissenschaftliche Forschung war und ist Gegenstand vielfältiger Kritik. Neben impliziten philosophischen und gesellschaftstheoretischen Grundannahmen werden auch methodologische Probleme adressiert. Eileen Wengemuth bietet hierzu eine verständliche Zusammenfassung, ordnet die verschiedenen Kritikpunkte systematisch ein und geht der Frage nach, wie Neurowissenschaftler•innen sich zu verschiedenen Kritikpunkten positionieren und was sie selbst an ihrem Fach kritisieren. Darüber hinaus legt sie dar, wie die Antworten auf diese Fragen mit den Rahmenbedingungen ökonomisierter Wissenschaft sowie mit unterschiedlichen Wissenschaftsverständnissen vermittelt sind.

This book asserts the emergence of the fourth era of entrepreneurship, based on a brain-driven approach to the study, instruction, and practice of entrepreneurship. This paradigm shift stems from the need to incorporate appropriate neurotechnologies into the exploration and enhancement of entrepreneurial phenomena in order to best address the field's methodological challenges. The author explains why a paradigm shift is necessary in the field of entrepreneurship and provides the foundational guidelines for those interested in implementing it. Furthermore, a model of entrepreneurial enhancement is conceptualized and signalled as the ultimate goal of this new era. Scholars, practitioners, policymakers, and students interested in advancing entrepreneurship's contribution to academia, business, and society at large will benefit from this new era's multidisciplinary perspective and unique strengths.

This book is designed to impart and convey knowledge as well as understanding of the range of biometric technologies and cybertechnologies, while also stressing their advantages and disadvantages. The authors develop an appreciation for and breadth of knowledge that spans the full range of neuroscience sub-disciplines, including behavioural, cognitive, and computational neuroscience. Furthermore, the content of the book is geared to be able to place neuroscience into an ethical context, especially showing how studying the brain and behaviour can contribute to the resolution of ethical, social, and environmental issues.

One day in 1996, the neuroscientist Eric R. Kandel took a call from his program officer at the National Institute of Mental Health, who informed him that he had been awarded a key grant. Also, the officer said, he and his colleagues thought Kandel would win the Nobel Prize. “I hope not soon,” Kandel's wife, Denise, said when she heard this. Sociologists had found that Nobel Prize winners often did not contribute much more to science, she explained.In this book, Kandel recounts his remarkable career since receiving the Nobel in 2000—or his experience of proving to his wife that he was not yet “completely dead intellectually.” He takes readers through his lab's scientific advances, including research into how long-term memory is stored in the brain, the nature of age-related memory loss, and the neuroscience of drug addiction and schizophrenia. Kandel relates how the Nobel Prize gave him the opportunity to reach a far larger audience, which in turn allowed him to discover and pursue new directions. He describes his efforts to promote public understanding of science and to put brain science and art into conversation with each other. Kandel also discusses his return to Austria, which he had fled as a child, and observes Austria's coming to terms with the Nazi period. Showcasing Kandel's accomplishments, erudition, and wit, There Is Life After the Nobel Prize is a candid account of the working life of an acclaimed scientist.

Please note: This is a companion version & not the original book. Book Preview: #1 The frog and the scorpion are sitting on the bank of a river, and the frog needs to get to the other side. The frog is suspicious of the scorpion, but allows him to ride on his back across the river. At first everything goes according to plan, but halfway across, the frog suddenly feels a sharp pain in his back and sees the scorpion withdraw his stinger. #2 The brains of psychopaths and non-psychopaths are similar, and there is no difference between them. However, a dead brain is very different from a living one, and the lights are on when examining a brain, not off. #3 The brain waves of psychopaths are different from normal people, and they occur during normal waking states. Language is only word deep for psychopaths, and they have no emotional contouring behind their words. #4 Fabrizio Rossi, the curator of the Museum of Serial Killers in Florence, Italy, said that the most intriguing thing about psychopaths is their normal appearance. But scratch beneath the surface, and you never know what you might find.

This book contains twelve chapters describing recent advancements in neuroscience research. Chapter One summarizes the role of cerebrospinal fluid biomarkers in the health and disease of dogs. Chapter Two discusses the neuroprotective effects of erythropoietin. Chapter Three focuses on the development of several mesencephalic areas using tyrosine hydroxylase immunocytochemistry and tritiated thymidine autoradiography. Chapter Four presents a study of the cerebellum of different age members of the same family using gravitational mass spectroscopy. Chapter Five explores how the conformations of nucleosomes and their states in the spirals of solenoids are responsible for the processes of short-term and long-term memory as well as other brain functions. Chapter Six deals with cognitive decline and depression associated with severe asymptomatic carotid stenosis. Chapter Seven describes the surgical technique of extensive craniofacial reconstruction for unilateral anterior plagiocephaly treatment. Chapter Eight gives a model of the molecular cause of pain based on a study of human fingers conducted via gravitational mass spectroscopy. Chapter Nine deals with the role of globules in the work of the brain and the dynamics of their conformations. Chapter Ten explains how chromosome topology is formed in vivo. Chapter Eleven explores the relationship between mild traumatic brain injury and residual cognitive impairment. Finally, Chapter Twelve examines stochastic resonance in the context of human sensory systems.

The Neuroscience of Dementia brings together different fields of dementia research into a single book, covering a wide range of subjects, including Alzheimer's disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. This foundational, comprehensive book compiles the latest understanding on all forms of dementia and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. - Offers comprehensive coverage of a broad range of topics related to dementia - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations - Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations - Serves as a'one-stop'source for everything you need to know about dementia

Physiotherapy and rehabilitation applications in neurological diseases are important for the treatment of the disease. The basic principle of physiotherapy and rehabilitation is to determine the needs of the patient. As such, the authors discuss the evaluation of the motor functions of neurological diseases for upper and lower extremities separately, as well as sensorial functions and cognitive functions. Next, a literature review draws attention to studies in which sex was a controlled variable, and presents data regarding sexual dimorphism in a range of aspects developed after brain injury. It is possible to document the accomplishments of different cell death mechanisms and varying degrees of inflammatory response depending on the sex, as well as the distinct susceptibilities of the sexes in terms of mechanisms of cell damage. Additionally, summary of techniques and indications related to cerebrovascular bypass surgery for aneurysmal subarachnoid hemorrhage cases is provided, maintaining that cerebral revascularization procedures should be further developed by neurosurgeons as they remain the only option of treatment for a significant number of patients. The authors review their extensive experience with indocyanine green video-angiography and FLOW 800 analysis software during the surgical removal of central nervous system tumors; in particular, they identified 5 possible applications of indocyanine green video-angiography and FLOW 800 in this field. Data is presented showing the reciprocity between the brain angiotensin II system and amphetamine exposure in the development and expression of behavioral, neurochemical and glial alterations. Particularly, this collection explores how the neuroadaptative responses and neuroinflammation evoked by the psychostimulant and depending on AT1 receptors that might resemble some features linked to different brain disorders. Lastly, a brief overview of the investigational history in research work on receptor/G-protein coupling is presented. Subsequently, the most recent experimental results in the re-establishment of [35S]GTPyS binding/immunoprecipitation assay are described.

Recent Advances in Parkinson´s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson´s disease, and much more. - Covers all key aspects of current research on Parkinson´s disease - Includes topics that range from basic studies on disease models and pathogenic pathways (e.g., protein misfolding, immune and glial mechanisms) to clinical studies on disease features, microbiome, pathophysiology and therapeutic approaches - Presents articles authored by world leaders in their respective fields

Jednoho dne zkoumal osmapadesátiletý Fallon hromádku skenů mozků svých rodinných příslušníků: obrázků, které měly sloužit jako kontrolní záznamy určené ke srovnání se snímky pacientů s Alzheimerem. Úplně vespod ležel snímek, který zjevně odpovídal mozku psychopata. Fallon si pomyslel, že se tam přimíchal nedopatřením ze štosu snímků opakovaně trestaných násilníků, takže se domluvil s techniky, že zkontrolují, komu záznam patří. Ti nade všechny pochybnosti prokázali, že nikdo nic nepopletl a inkriminovaný sken pochází skutečně od Fallonovy rodiny. Jednalo se o jeho vlastní mozek.V knize Psychopat v mém mozku se prolíná autorovo zamyšlení nad neurologickým a genetickým základem a příčinami psychopatie s vyznáním popisujícím, co všechno se o sobě dozvěděl od svých kolegů a rodinných příslušníků, i zamyšlením nad tím, zda lze psychopaty změnit a čím mohou takoví lidé prospět světu. James H. Fallon je profesor v oboru neurověd působící 40 let na Kalifornské univerzitě. Je nositelem několika ocenění i majitelem úspěšných firem v oboru biotechnologií, spolupracuje s americkým ministerstvem obrany. Pravidelně se objevuje v médiích.

The ability to anticipate and make accurate decisions in a timely manner is fundamental to high-level performance in sport. This is the first book to identify the underlying science behind anticipation and decision making in sport, enhancing our scientific understanding of these phenomena and helping practitioners to develop interventions to facilitate the more rapid acquisition of the perceptual-cognitive skills that underpin these judgements.Adopting a multidisciplinary approach — encompassing research from psychology, biomechanics, neuroscience, physiology, computing science, and performance analysis — the book is divided into three sections. The first section provides a comprehensive analysis of the processes and mechanisms underpinning anticipation and skilled perception in sport. In the second section, the focus shifts towards exploring the science of decision making in sport. The final section is more applied, outlining how the key skills that impact on anticipation and decision making may be facilitated through various training interventions.With chapters written by leading experts from a vast range of countries and continents, no other book offers such a synthesis of the historical development of the field, contemporary research, and future areas for investigation in anticipation and decision making in sport. This is a fascinating and important text for students and researchers in sport psychology, skill acquisition, expert performance, motor learning, motor behaviour, and coaching science, as well as practicing coaches from any sport.

The corpus callosum is a flat bundle of commissural fibers, beneath the cerebral cortex in the brain, the mild encephalitis/encephalopathy of which is rare in children. In Horizons in Neuroscience Research. Volume 36, the authors report 23 cases in children and summarize the clinical manifestations, imaging features, prognosis, and possible causes and pathogenesis of these patients. Continuing, this compilation describes the anatomy of the sphenopalatine ganglion and the pathophysiological role of the ganglion in different neurological disorders. Various approaches, methods and techniques are discussed, along with their advantages and limitations. Cognitive decline and symptoms of attention deficits, executive dysfunction, and memory impairments are all symptoms of dementia in the elderly. One review focuses on particular frequency oscillations that occur within the affected brain regions which may be used to classify some idiopathic dementias as specific diseases, and could contribute additional information to the clinical data in evaluating age changes. Next, the authors propose that zebrafish may aid in attaining a comprehensive understanding of neural development, neurological disease, and the future treatment of these disorders. They are cost-effective, have a high fecundity, are amenable to genetic manipulation, and are not as susceptible to embryonic lethality in certain circumstances because of gene duplication. Most importantly, their development is highly conserved and they share a similar number of chromosomes relative to both humans and mice, the latter being the most commonly used model system to study neurodevelopmental disorders. Another study focuses on cerebral microcirculation and angioarchitectonics disorders in Alzheimer's disease (AD) as compared to other neurodegenerative and ischemic diseases. 1122 patients with different types and stages of neurodegenerative and ischemic diseases were examined: 93 patients with different AD stages, 5 AD patients'direct descendants aged 8-11, and 1024 patients with other neurodegenerative and ischemic brain disorders. Small non-coding RNAs (ncRNAs) represent a diverse group of gene regulatory factors that can post-transcriptionally regulate gene expression in response to various stimuli during brain development and differentiation. The authors discuss the link between ncRNAs, and miRNA in particular, and the regulation of ubiquitine-proteasome pathways and neurodegeneration. The following study aimed to evaluate the effect of implementation intention on naturalistic prospective memory performance in individuals with schizotypal personality features. A total of 48 individuals with schizotypal personality features and 50 participants without schizotypal personality features participated in the study. Diagnosis of occult otogenic cerebrospinal fluid leakage is challenging and the disease may easily be misdiagnosed. In the closing chapter, the authors propose that if a patient presents repeatedly with otorrhea or rhinorrhea with history of head injury, traumatic cerebrospinal fluid leakage should be considered. Additionally, Different surgical techniques should be adopted such as the transmastoid/translabyrhithine approach, or packing the vestibular organs to treat the cerebrospinal fluid leakage based on the source.

This book is a practical resource designed for clinicians, researchers, and advanced students who wish to learn about single-case research designs. It covers the theoretical and methodological underpinnings of single-case designs, as well as their practical application in the clinical and research neurorehabilitation setting. The book briefly traces the history of single-case experimental designs (SCEDs); outlines important considerations in understanding and planning a scientifically rigorous single-case study, including internal and external validity; describes prototypical single-case designs (withdrawal-reversal designs and the medical N-of-1 trial, multiple-baseline designs, alternating-treatments designs, and changing-criterion designs) and required features to meet evidence standards, threats to internal validity, and strategies to address them; addresses data evaluation, covering visual analysis of graphed data, statistical techniques, and clinical significance; and provides a practical ten-step procedure for implementing single-case methods. Each chapter includes detailed illustrative examples from the neurorehabilitation literature.Novel features include: A focus on the neurorehabilitation setting, which is particularly suitable for single-case designs because of the complex and often unique presentation of many patients/clients. A practical approach to the planning, implementation, data analysis, and reporting of single-case designs. An appendix providing a detailed summary of many recently published SCEDs in representative domains in the neurorehabilitation field, covering basic and instrumental activities of daily living, challenging behaviours, disorders of communication and cognition, mood and emotional functions, and motor-sensory disabilities. It is valuable reading for clinicians and researchers in several disciplines working in rehabilitation, including clinical and neuropsychology, education, language and speech pathology, occupational therapy, and physical therapy. It is also an essential resource for advanced students in these fields who need a textbook for specialised courses on research methodology and use of single-case design in applied clinical and research settings.

Thirty years ago, the groundbreaking Geschwind-Galaburda hypothesis defined the field of dyslexia, revealing and analyzing the complex associations among brain development, hormones, immune activity, and brain lateralization. This important volume revisits the hypothesis three decades later and explores key questions: What have we learned since then, and what still needs to be investigated?Based on presentations from the 2016 Extraordinary Brain Symposium—and co-edited by one of the authors of the original hypothesis—this book synthesizes current dyslexia findings from more than 30 top researchers and practitioners. The contributors share diverse perspectives, concerns, challenges, and solutions, with brief jargon-free summaries at the beginning of each chapter to make the book accessible to a wider audience. Each chapter also points to research gaps and remaining questions to help shape future innovations from the next generation of researchers. A landmark addition to the literature on dyslexia and neuroscience, this forward-thinking volume should be on the shelf of every researcher and graduate student whose work focuses on neuroscience and dyslexia. EXPLORE CURRENT FINDINGS ONthe clinical and sociological aspects of dyslexia early atypical brain development in developmental dyslexiareading in children with developmental disordersbrain asymmetries and sex differences in developmental dyslexiasex differences in cognition and learningintergenerational transmission of reading and reading brain networksanimal models of early neural disruptionthe genetic factors that underlie handedness and left hemisphere language dominancethe genetics of specific reading disabilityand more essential dyslexia topicsWith contributions byDavid UrionJohn L.R. RubensteinGeert J. de VriesThomas G. O’ConnorTuong-Vi NguyenMargaret M. McCarthyFranck RamusEileen LudersDavid S. HongR. Holly FitchLaurie CuttingElena GrigorenkoSebastian Ocklenburg Silvia ParacchiniSergey Kornilov Heidi FeldmanNicole Landiand more

The best-selling author of Subliminal and The Drunkard's Walk teaches you how to tap into the hidden power of your brain. “Elastic is a book that will help you survive the whirlwind.”—Daniel H. Pink, author of When and A Whole New MindNamed to the 800-CEO-READ Business Book Awards Longlist In this startling and provocative look at how the human mind deals with change, Leonard Mlodinow shows us to unleash the natural abilities we all possess so we can thrive in dynamic and troubled times. Truly original minds capitalize when everyone else struggles. And most of us assume that these abilities are innate, reserved for a select few. But Mlodinow reveals that we all possess them, that we all have encoded in our brains a skill he terms elastic thinking—and he guides us in how to harness it. Drawing on groundbreaking research, Mlodinow outlines how we can learn to let go of comfortable ideas and become accustomed to ambiguity and contradiction; how we can rise above conventional mindsets and reframe the questions we ask; and how we can improve our ability to solve problems and generate new ideas—critical skills for achieving professional and personal success in our quickly morphing world.

La segunda edición de Principios de Neuroeducación Física es una introducción a la neurociencia y a los avances en investigación de los efectos del ejercicio físico sobre la percepción (propiocepción, audición y visión), los sistemas de regulación (sueño, motivación y emoción) y funciones cognitivas (atención, planificación, memoria y aprendizaje), estableciendo un vínculo entre la practica física y el funcionamiento del sistema nervioso. ¿Es posible que la práctica de ejercicio físico mejore el desempeño atencional, de memoria o control emocional, ¿la condición física se relaciona con el aprendizaje y la resolución de problemas, ¿es suficiente la aplicación de una sola sesión de entrenamiento o es necesaria una intervención durante varios meses para notar mejoras en las funciones cerebrales Todas estas preguntas abren un mundo de estudio que dan cuenta del efecto de la practica física que va más allá del rendimiento deportivo, la estética o la composición corporal, un ámbito donde se entremezcla lo motriz y lo cognitivo. El presente libro es un intento de aunar la neurociencia con la educación física, de manera rigurosa y científica, para dar un nuevo enfoque a la practica de ejercicio físico de nuestros países, basada en la mejora de la calidad de vida a través una mejora de la actividad cerebral.

This book shows how to develop efficient quantitative methods to characterize neural data and extra information that reveals underlying dynamics and neurophysiological mechanisms. Written by active experts in the field, it contains an exchange of innovative ideas among researchers at both computational and experimental ends, as well as those at the interface. Authors discuss research challenges and new directions in emerging areas with two goals in mind: to collect recent advances in statistics, signal processing, modeling, and control methods in neuroscience; and to welcome and foster innovative or cross-disciplinary ideas along this line of research and discuss important research issues in neural data analysis. Making use of both tutorial and review materials, this book is written for neural, electrical, and biomedical engineers; computational neuroscientists; statisticians; computer scientists; and clinical engineers.

The first book to present DSM-5 diagnoses within a systems contextThe first text to present DSM-5 diagnoses within a relational perspective, DSM-5 and Family Systems delivers timely content aimed at training marriage and family therapists, clinical mental health counselors, and other systems-oriented practitioners. It reflects how the DSM-5 examines, for the first time, its diagnostic categories from the perspective of cultural and environmental impact on the development of individual disorders and conditions. This comprehensive text provides students with an understanding of how to approach a diagnosis as it relates to assessments, treatment planning, and ethical implications from a family and relational systems perspective. With contributions from distinguished faculty at counseling and marriage and family therapy training programs, each chapter includes an overview of the DSM in family systems contexts, cultural aspects, family systems assessments and interventions, and ethical and legal implications. Abundant case vignettes aid students in conceptualizing diagnoses in each DSM-5 category.Key Features:Considers all categories of DSM-5 diagnoses from a family and relational systems perspective—the first book to do soIncludes family systems contexts, assessments, interventions, cultural considerations, and ethical and legal implicationsProvides sample case vignettes for conceptualization of each DSM-5 categoryWritten and edited by esteemed educators in counseling and MFTDesigned for courses in diagnosis, assessment, and psychopathology

This book covers recent advances in the understanding of brain structure, function and disorders based on the fundamental principles of physics. It covers a broad range of physical phenomena occurring in the brain circuits for perception, cognition, emotion and action, representing the building blocks of the mind. It provides novel insights into the devastating brain disorders of the mind such as schizophrenia, dementia, autism, aging or addictions, as well as into the new devices for brain repair. The book is aimed at basic researchers in the fields of neuroscience, physics, biophysics and clinicians in the fields of neurology, neurosurgery, psychology, psychiatry.

This book provides readers with the latest developments in neuroscience research. Chapter One presents nonlinear features of EEG changes during auditory – verbal short-term memory task for words and nonwords. Chapter Two analyzes studies investigating the discriminative power of the Hopkins Verbal Learning Test to screen for dementia. Chapter Three reviews demential with lewy bodies. Chapter Four examines the relationship between age and verbal working memory (WM) performance in healthy adults, ages 18 to 90. Chapter Five studies the differences in pointing versus performing a pathway in 4-5 year old childrens'topographical working memory. Chapter Six discusses the development of nicotine acetylcholine receptor imaging probes and their use for the functional analysis of nicotinic acetylcholine receptors in neuropathic pain. Chapter Seven reviews the dorsal raphe nucleus neurons as targets for the presynaptic effects of nicotine. Chapter Eight focuses on the contextual modulation of motion velocity.

This book provides readers with the latest developments in neurosciences research. Chapter One reports on how neural network learning is possible in patients who are not conscious including patients in the vegetative state. Chapter Two is written for educational therapists who are working with ASD cases and the aim is twofold. Firstly, it is to raise the awareness among educational therapists on current neuroscientific studies on the autistic brain and its ASCs (and hence, ASD). Secondly, it is to inform how the findings from these neuroimaging studies can be translated into praxiological implications in autism treatment plan design for educational therapists. Chapter Three studies the postoperative cognitive dysfunction (POCD) in patients after cardiac surgeries along with extensive review of the literature in this field. At least three types of POCD may be outlined, and therefore tests sensitive to each type of POCD should be included into test batteries. Chapter Four integrates the results of prior publications and recent additional findings providing indications for a functional cross-interlocking of inter- and intramuscular sequencing patterns as a fundamental principle to enhance human movement´s efficiency. Chapter Five reports on strabismus which is the most frequent ocular surgery performed in childhood and requires anesthesia that provides akinesia, analgesia, and sometimes ocular hypotonia, to adjust sutures. Chapter Six studies the posterodorsal medial amygdala (MePD) which is involved in the display of reproductive behavior in both male and female rats. Further studies demonstrated that it also integrates a subcortical ‘social behavior network'with additional, but selective modulatory roles.

Can you really rewire an adult brain?In theory the answer is'yes', but there's a problem: no one seems to know exactly how to do it. In Override, science journalist Caroline Williams sets off on a mission to find the answer. Delving into the latest studies on brain plasticity, which indicate that brain games don't actually do much to make you smarter, she tries to square her findings with the reality of brain plasticity — that the brain adapts physically as we learn something new. Visiting top neuroscientists in their labs, Williams volunteers herself as a guinea pig in neuroscience studies, challenging researchers to make real changes to her — functioning, but imperfect — brain. Seeking first to improve on her own weaknesses, such as a limited attention span and a tendency to worry too much, she then branches out into more mysterious areas such as intelligence, creativity, and the perception of time.Trying everything from high-tech brain stimulation to meditation, adding bolt-on senses and retraining her stress response, Override is a very intimate, fascinating journey into discovering what neuroscience can really do for us — and, crucially, whether it's worth all the bother. PRAISE FOR CAROLINE WILLIAMS ‘A more nuanced understanding of how our brains really work that is both empowering and insightful.'The Irish Times ‘Presented in crisp chapters, Override is a diverting investigation into how neuroscience can nudge us towards making more efficient use of our brain's resources.'The Irish Examiner

This book provides readers with the latest developments in neurosciences research. Chapter One provides a selective overview of the empirical contributions available in the last decade for promoting independence and self-determination of children with rare genetic syndromes and severe to profound developmental disabilities through cognitive-behavioral interventions and assistive technology-based programs. Chapter Two evaluates the influence of VPA and LEV as monotherapy on vitamin D status among children with epilepsy. Chapter Three characterizes the intercorrelations and different factors contributing to whole brain voxel-wise blood flow measures based on standard imaging metrics. Chapter Four summarizes current knowledge about the determination of individual subunits of the neurofilament triplet in cerebral and spinal cord ischemia. Chapter Five provides a new approach to the restoration of degraded visual functions and expands our knowledge of perception and consciousness. Chapter Six describes PlaymoCase as a means of a play-therapeutic approach with the regard to its content and its relationship to the Operationalized Psychodynamic Diagnosis in Childhood and Adolescence in the revised version (OPD-CA2). Chapter Seven discusses structural linguists and how speaking amounts to transforming a structural order into a linear one, and understanding a sentence to turning a linear order into a structural one. Chapter Eight investigates the responses to images of human faces in which the spatial Fourier spectra have been manipulated.

Why a text on neuroscience and Christian formation? Simply put, we need one that represents the range of possible intersections for today and into the future. In recent years, neuroscience's various fields of study have influenced our understanding of the person, memory, learning, development, communal interaction, and the practice of education. The book serves as an introductory textbook for Christian education/formation professors to use in Christian education or Christian formation courses at the College or Seminary level. The book is designed to provide an overview of how current research in neuroscience is impacting how we view Christian education and formation with particular attention given to faith formation, teaching, development, and worship The first four chapters discuss how neuroscience broadly influences Christian education and formation. Chapters five through eight explore how neuroscience informs specific formational practices, from personal meditation, to intercultural encounter, to congregational formation and worship. The last four chapters explore various aspects of neuroscience along developmental lines, The book also moves from conceptual overviews to more empirical studies late in the text. Each chapter of this book can also be read and discussed individually. Each author has provided both discussion topics, suggestions for future reading within neuroscience, and discussion questions at the end of the chapter.

The phenomena of motivation cannot be studied separately as an independent research topic because motivation is highly interrelated to cognition, emotion, learning, and decision-making process. The overarching aim of this volume, therefore, is to provide new insight into a unified grand theory of motivation by integrating noteworthy neuroscience research findings on motivation. This volume is dedicated to advancing our understanding of brain mechanisms of underlying various motivational phenomena, including reward, approach, autonomy, intrinsic motivation, learning, effort, curiosity, and self-control. The volume is divided into four parts: The first part introduces classical but fundamental issues such as reward, approach, and individual differences. The second part deals with intrinsic motivation including autonomy and curiosity. The third one examines recent approaches on the interface between motivation and cognition in learning and decision-making. The last part focuses on practically significant issues pertaining to self-regulation development.

This book provides readers with the latest developments in neuroscience research. Chapter One discusses the development of neurochemical characteristics of sensory neurons. Chapter Two reviews current knowledge regarding Mavridis'area (MA) and its role as a modern stereotactic microanatomic guide for nucleus accumbens (NA) deep brain stimulation (DBS). Chapter Three describes the molecular mechanisms in response to exposure of the central nervous system (CNS) cells to the Ca2+ ionophores to increase the levels of intracellular free Ca2+ and consequently oxidative stress, and it also describes the roles of activation of the Ca2+-dependent proteases and intracellular pathways leading to induction of programmed cell death. Chapter Four reviews clinical features, epidemiology, genetics, physiopathology, management and advanced research on Frontotemporal Dementia and Frontotemporal Lobar Degeneration (FTLD). Chapter Five explores different terpenes and their role in signaling pathway modulating the progression of Alzheimer Disease. Chapter Six discusses the capability of and limitations in PET imaging research on non-human primates for translation to humans for brain aging research as well as therapeutic drug development for neurodegenerative diseases. Chapter Seven studies the imaging markers and prognostic significance of intracerebral hemorrhages (ICH). Chapter Eight reviews clinical practices and surgical intervention for ICH.

De Leidraad Neurologie, uitgevoerd in handig zakformaat, geeft een handleiding voor neurologisch onderzoek. Het neurologisch onderzoek omvat het klinisch onderzoek naar de functie van het zenuwstelsel en is vooral bedoeld om functiestoornissen aan het licht te brengen. Door de subtiele organisatie van het zenuwstelsel is het vaak mogelijk om niet alleen de dysfunctie vast te stellen, maar ook de onderliggende functiestoornis te lokaliseren. Dit laatste vormt dan het uitgangspunt voor aanvullend hulponderzoek, waarbij de neuroloog meer en meer terugvalt op neuro-imaging, een diagnostische techniek die zich stormenderhand ontwikkelt. Op deze techniek is deze leidraad dan ook gebaseerd. Het accent ligt vooral op het'waarom'van een bepaald onderzoek. Om dit inzicht te bevorderen, wordt als regel teruggevallen op de onderliggende neuroanatomie en neurofysiologie, zoals behandeld in het leerboek Neurologie: structuur, functie en dysfunctie van het zenuwstelsel. De Leidraad Neurologie verschijnt in de Co-reeks, een nieuwe reeks praktische boekjes in zakformaat voor (aankomend) artsen, studenten geneeskunde, beginnende assistenten en paramedici.

This book provides readers with the latest developments in neuroscience research. Topics covered include patient and nerve selection, review techniques, risks, benefits and alternatives to C2 and RFA ablation; early diagnosis and treatment in multiple sclerosis using ultrashort echo time (UTE) magnetic resonance imaging; the use of regenerative medicine to help patients with ataxia; genetic and clinical characteristics of spinocerebellar ataxias; white matter abnormalities in neurodegenerative disease; cell to cell propoagation of pathogenic tau which may be involved in certain neurodegenerative disorders; the use of cannabis in neurology and psychiatry and its potential effects; deep brain stimulation for treating neuropsychiatric disorders; and the symptoms, anesthetic management and potential complications of Charcot-Marie-Tooth Disease.

Overview: For his first fifty-eight years, James Fallon was by all appearances a normal guy. A successful neuroscientist and professor, he'd been raised in a loving family, married his high school sweetheart, and had three kids and lots of friends. Then he learned a shocking truth that would not only disrupt his personal and professional life, but would lead him to question the very nature of his own identity. While researching serial killers, he uncovered a pattern in their brain scans that helped explain their cold and violent behavior. Astonishingly, his own scan matched that pattern. And a few months later he learned that he was descended from a long line of murderers. Fallon set out to reconcile the truth about his own brain with everything he knew as a scientist about the mind, behavior, and personality.

This compilation presents original study results on the leading edge of neuroscience research. Each article has been carefully selected in an attempt to present substantial research results across a broad spectrum. Included in this volume are consequences of sub-concussion and concussion in male ice hockey players; respiratory disorders of newborn with syndromic and non-syndronic neurological disease; role of neural crest in tuberous sclerosis complex; spinal tumors in tuberous sclerosis; and semantics with or without categorization.

Experts from academia and industry discuss how to create a new, more effective translational neuroscience drawing on novel technology and recent discoveries. Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics, stem cell biology, and neuroscience emerged to offer new possibilities. In this volume, experts from both academia and industry discuss how novel technologies and reworked translation concepts can create a more effective translational neuroscience. The contributors consider such topics as using genomics and neuroscience for better diagnostics and biomarker identification; new approaches to disease based on stem cell technology and more careful use of animal models; and greater attention to human biology and what it will take to make new therapies available for clinical use. They conclude with a conceptual roadmap for an effective and credible translational neuroscience—one informed by a disease-focused knowledge base and clinical experience.ContributorsTobias M. Böckers, Thomas Bourgeron, Karl Broich, Nils Brose, Bruce N. Cuthbert, Ilka Diester, Gül Dölen, Guoping Feng, Richard Frackowiak, Raquel E. Gur, Stephan Heckers, Franz Hefti, David M. Holtzman, Steven E. Hyman, Nancy Ip, Cynthia Joyce, Tobias Kaiser, Edward H. Koo, Walter J. Koroshetz, Katja S. Kroker, Robert C. Malenka, Isabelle Mansuy, Eliezer, Masliah, Yuan Mei, Andreas Meyer-Lindenberg, Lennart Mucke, Pierluigi Nicotera, Karoly Nikolich, Michael J. Owen, Menelas N. Pangalos, Alvaro Pascual-Leone, Joel S. Perlmutter, Trevor W. Robbins, Lee L. Rubin, Akira Sawa, Mareike Schnaars, Bernd Sommer, Maria Grazia Spillantini, Laura Spinney, Matthew W. State, Marius Wernig

This compilation presents original study results on the leading edge of neuroscience research. Each article has been carefully selected in an attempt to present substantial research results across a broad spectrum. Included in this volume is research on holographic memory; epilepsy and psychiatric co-morbidities; emotional modulation of prepulse inhibition of the startle response in humans; neuroimaging and electrophysiology efficacy in measuring acute effects and long-term sequelae following sports-related concussion; children with writing disabilities; neuroimmune connections in the posterior nasopharyngeal cavity; pulse attraction-repulsion; autism spectrum disorders in children and adolescents with neurofibromatosis type 1; avidity of autoantibodies against antigens in nervous tissue; epidemiological study of childhood epilepsy using the newly classification proposed by the international league against epilepsy; and the role of neuromuscular ultrasound in the diagnostic of the multifocal motor neuropathy.

Current Laboratory Methods in Neuroscience Research is a research manual for both students and seasoned researchers. It focuses on commonly-used techniques employed in neuroscience research, presented in a simple, step-by-step manner for laboratory use. The manual also offers a “blueprint” for bench-to-bedside research designed to facilitate multidisciplinary neuroscience pursuits. Sections include coverage of neurohistological techniques, in vitro preparations, leukocyte isolation and application in neuroscience, standard laboratory nucleic acid and protein detections, nanomedicine, bioimaging, neuroelectrophysiology, immunohistochemistry and autoradiography, analysis of gene expression, and animal models.

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

This compilation presents original study results on the leading edge of neuroscience research. Each article has been carefully selected in an attempt to present substantial research results across a broad spectrum. Included in this volume are molecular mechanisms integrating adenylyl cyclase responsiveness to metabolic control on long term emotional memory and associated disorders; homeostatic synaptic plasticity; reorganization of elementary functions after brain injury and in the intact brain; the effects of acoustic stimulation on comatose patients; the splitting of the brain; the role of mineralocorticoid receptors in major depressive disorder; betaine in the brain; clinical outcome prediction using Bayesian regression and artificial neural networks; pathological changes of event-related brain oscillations in Parkinson's disease; the impact of sub thalamic stimulation on autonomic dysfunction in Parkinson's disease.

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume explores interdisciplinary research on invertebrate and vertebrate models of odor memory and perception, as well as human odor memory and perception. This book brings together a collection of authors that cut across model systems, techniques, levels of analysis and questions to highlight important and exciting advances in the area of olfactory memory and perception. The chapters highlight the unique aspects of olfactory system anatomy, local circuit function, odor coding and plasticity. The authors are leading authorities in the field. - Written by the leading researchers in the field of olfactory perception and memory - Includes diverse models systems from invertebrates to humans - Includes diverse technical approaches to the study of olfactory memory and perception Includes overview of the most recent research advances in this field

Science is growing at a pace that exceeds our comprehension. This is no less true of neuroscience than any other discipline. Ambiguity about what is known and what has been disproven confounds researchers and hampers research planning. There are simply too many research articles and too few hours in the day for anyone to read all that is relevant, let alone distinguish the reliable results from the sketchy ones. Engineering the Next Revolution in Neuroscience explores the proposal that we can overcome these obstacles to scientific progress, and revolutionize neuroscience, by using a framework to map the experimental record. With case studies from learning and memory research, the authors show that we can construct networks of experimental research that make the state of our knowledge manifest. Armed with maps of experiments, scientists can determine more efficiently what their fields have accomplished and where the unexplored territories still reside.

“Compelling, essential reading for understanding the underpinnings of psychopathy.” — M. E. Thomas, author of Confessions of a SociopathFor his first fifty-eight years, James Fallon was by all appearances a normal guy. A successful neuroscientist and professor, he'd been raised in a loving family, married his high school sweetheart, and had three kids and lots of friends. Then he learned a shocking truth that would not only disrupt his personal and professional life, but would lead him to question the very nature of his own identity.While researching serial killers, he uncovered a pattern in their brain scans that helped explain their cold and violent behavior. Astonishingly, his own scan matched that pattern. And a few months later he learned that he was descended from a long line of murderers. Fallon set out to reconcile the truth about his own brain with everything he knew as a scientist about the mind, behavior, and personality.

This compilation presents original study results on the leading edge of neuroscience research. Each article has been carefully selected in an attempt to present substantial research results across a broad spectrum.Included in this volume is the role of estrogen on cognitive functions; brain disorders, brain medicines and the blood-brain barrier; brain auditory processing during behavior seen from unitary activity; neuroinflammatory factors as targets against neurological and psychiatric disorders; the psychoneuroendocrinology of music effects on health; the neuroprotective mechanism of fibronectin and neural models for social development in shared parieto-motor circuits. (Imprint: Nova Biomedical)

This compilation presents original study results on the leading edge of neuroscience research. Each article has been carefully selected in an attempt to present substantial research results across a broad spectrum. Included in this volume is the regulation of neuronal morphology and plasticity by small GTP-binding proteins and its implication in autism and mental retardation; memory and cognitive dysfunctions in Alzheimer's disease with neuroinflammation due to aging, obesity, and obstructive sleep apnea; processing magnitudes within the parietal cortex; cognitive impairment in system lupus erythematosus; and compensatory memory processes in mild cognitive impairment.

Translational research looks to take the latest innovations made in the laboratory setting to translate findings into effective and sustainable medical interventions and improved preventative measures. Funding support is increasingly tied to practical healthcare outcomes, with this trend likely only to increase in coming years, Translational Neuroscience: A Guide to a Successful Program, is a timely guide to developing research programs that bring translational advances to the forefront. Translational Neuroscience provides practical information from scientists with first-hand experience in developing a cutting-edge translational facility. The book opens with chapters that provide guidance to organizing a center for translational science. Chapters look at topics ranging from mentoring and career planning for clinician scientists to improving the design of core facilities and addressing infrastructure needs. The second half of the book provides valuable case studies of translational neuroscience in action, with examples ranging from using to transcranial magnetic stimulation to studies on drug abuse and telemedicine applications. The final chapter looks to the future of basic science research, how academic health centers can be reorganized, and how future generations of translational neuroscientists can be trained. Translational Neuroscience provides a blueprint to developing an innovative and successful translational research program. Deans, department chairs, academic health center administrators, and researchers will find this guide useful for drafting programs in translational research and avoiding costly pitfalls. While grounded in examples from basic neuroscience research, this book will be a useful tool to all scientists looking to develop centers of translational science across research disciplines.

Biological differences between the sexes influence not only individual health but also public health, biomedical research, and health care. The Institute of Medicine held a workshop March 8-9, 2010, to discuss sex differences and their implications for translational neuroscience research, which bridges the gap between scientific discovery and application.

This book presents current research in the field of neuroscience. Topics discussed include noradrenergic actions in prefrontal cortex; prefrontal morphology, neurobiology and clinical manifestations of schizophrenia; prefrontal cholinergic receptors; deep brain stimulation and cortical stimulation methods; deep brain stimulation in adult and pediatric dystonia; cognitive aspects in idiopathic epilepsy; cognitive interventions to improve prefrontal functions; molecular mechanisms involved in the pathogenesis of Huntington's disease and DNA repair and Huntington's disease.

This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods. - Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications - Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research - All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist

A properly designed and executed clinical trial that addresses an import question and delivers a definitive result can change the practice of medicine worldwide. This book encompasses a bench-to-bedside approach and serves as an excellent guidance for translating preclinical studies to early phase I/II and phase III trials. In the first part, the book covers preclinical science with respect to animal models of various neurological diseases, FDA requirements for preclinical studies, translation of animal to patient studies and scaling up from animal to human studies. In the second part, the design of phase I/II trials and the use of biomarkers as surrogate endpoints are discussed. With regard to phase III trials, FDA and European requirements, specific design issues, relevant clinical endpoints as well as data management and quality are examined. Topics specific to multicenter trials, such as design, recruitment of special populations, monitoring, ethical and consent issues are also covered. Finally, genetics, gene therapy, imaging and surgical devices are reviewed. This publication is highly recommended to clinician researchers, such as neurologists, neurosurgeons, pediatric neurologists and neonatologists, who want to design and conduct clinical trials in the neuroscience, but also to nurses, research coordinators and clinical pharmacologists.

Advances and major investments in the field of neuroscience can enhance traditional behavioral science approaches to training, learning, and other applications of value to the Army. Neural-behavioral indicators offer new ways to evaluate how well an individual trainee has assimilated mission critical knowledge and skills, and can also be used to provide feedback on the readiness of soldiers for combat. Current methods for matching individual capabilities with the requirements for performing high-value Army assignments do not include neuropsychological, psychophysiological, neurochemical or neurogenetic components; simple neuropsychological testing could greatly improve training success rates for these assignments. Opportunities in Neuroscience for Future Army Applications makes 17 recommendations that focus on utilizing current scientific research and development initiatives to improve performance and efficiency, collaborating with pharmaceutical companies to employ neuropharmaceuticals for general sustainment or enhancement of soldier performance, and improving cognitive and behavioral performance using interdisciplinary approaches and technological investments. An essential guide for the Army, this book will also be of interest to other branches of military, national security and intelligence agencies, academic and commercial researchers, pharmaceutical companies, and others interested in applying the rapid advances in neuroscience to the performance of individual and group tasks.