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1. Neuroprem: the Neuro-developmental outcome of very low birth weight infants in an Italian region

Author

Licia Lugli, Marisa Pugliese, Carlotta Plessi, Alberto Berardi, Isotta Guidotti, Gina Ancora, Sara Grandi, Giancarlo Gargano, Silvia Braibanti, Fabrizio Sandri, Silvia Soffritti, Elisa Ballardini, Vittoria Arena, Marcello Stella, Serafina Perrone, Sabrina Moretti, Vittoria Rizzo, Fabrizio Ferrari, Neuroprem Working Group, Odoardo Picciolini, Roberto Bellù, Daniela Turoli, Luigi Tommaso Corvaglia, Gianpaolo Garani, Vittoria Paoletti, Giacomo Biasucci, Augusto Biasini, Belinda Benenati, Paolo Stagi, Cristina Magnani, Sara Dallaglio, Elisa DellaCasa Muttini, Maria Federica Roversi, Luca Bedetti, Laura Lucaccioni, Natascia Bertoncelli, and Alessandra Boncompagni

Subjects
Neuro-developmental outcome, Very low birth weight preterm, Italy, Pediatrics, RJ1-570
Abstract

Abstract Introduction The survival of preterm babies has increased worldwide, but the risk of neuro-developmental disabilities remains high, which is of concern to both the public and professionals. The early identification of children at risk of neuro-developmental disabilities may increase access to intervention, potentially influencing the outcome. Aims Neuroprem is an area-based prospective cohort study on the neuro-developmental outcome of very low birth weight (VLBW) infants that aims to define severe functional disability at 2 years of age. Methods Surviving VLBW infants from an Italian network of 7 neonatal intensive care units (NICUs) were assessed for 24 months through the Griffiths Mental Developmental Scales (GMDS-R) or the Bayley Scales of Infant and Toddler Development (BSDI III) and neuro-functional evaluation according to the International Classification of Disability and Health (ICF-CY). The primary outcome measure was severe functional disability at 2 years of age, defined as cerebral palsy, a BSDI III cognitive composite score

Published
2020
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2. Neuroprem 2: An Italian Study of Neurodevelopmental Outcomes of Very Low Birth Weight Infants

Author

Licia Lugli, Luca Bedetti, Isotta Guidotti, Marisa Pugliese, Odoardo Picciolini, Maria Federica Roversi, Elisa DellaCasa Muttini, Laura Lucaccioni, Natascia Bertoncelli, Gina Ancora, Giancarlo Gargano, Fabio Mosca, Fabrizio Sandri, Luigi Tommaso Corvaglia, Agostina Solinas, Serafina Perrone, Marcello Stella, The Neuroprem Working Group, Lorenzo Iughetti, Alberto Berardi, Fabrizio Ferrari, Antonella Luglio, Sara Grandi, Valentina Fiorini, Piero Catenazzi, Elisa Ballardini, Sabrina Moretti, Daniela Turoli, Arianna Aceti, Roberto Bellù, Luca Ori, Silvia Braibanti, Alessandra Boncompagni, Caterina Spada, Lara Valeri, Lugli, Licia, Bedetti, Luca, Guidotti, Isotta, Pugliese, Marisa, Picciolini, Odoardo, Roversi, Maria Federica, DellaCasa Muttini, Elisa, Lucaccioni, Laura, Bertoncelli, Natascia, Ancora, Gina, Gargano, Giancarlo, Mosca, Fabio, Sandri, Fabrizio, Corvaglia, Luigi Tommaso, Solinas, Agostina, Perrone, Serafina, Stella, Marcello, Iughetti, Lorenzo, Berardi, Alberto, Ferrari, Fabrizio, and Aceti Arianna

Subjects
Pediatrics, medicine.medical_specialty, Population, Socio-culturale, very low birth weight, Bayley Scales of Infant Development, RJ1-570, Cerebral palsy, Intensive care, medicine, follow-up, Prospective cohort study, education, Original Research, education.field_of_study, business.industry, Gestational age, medicine.disease, network, neuro-developmental outcome, preterm, Low birth weight, Cohort, Pediatrics, Perinatology and Child Health, medicine.symptom, business
Abstract

Background: Despite the increased survival of preterm newborns worldwide, the risk of neurodevelopmental disabilities remains high. Analyzing the outcomes of the preterm population can identify risk factors and enable specific early interventions.Aims: Neuroprem is a prospective cohort study of very low birth weight (VLBW) infants that aims to evaluate the neurodevelopmental outcomes and risk factors for severe functional disability at 2 years of corrected age.Methods: Nine Italian neonatal intensive care units participated in the network. The Griffiths Mental Developmental Scales (GMDS-R) or the Bayley Scales of Infant and Toddler Development (BSDI III) and a neuro-functional evaluation (according to the International Classification of Disability and Health and Neuro-Functional Assessment, or NFA ICF-CY) were administered to VLBW infants at 24 months of corrected age. The primary outcome measure was severe functional disability, defined as cerebral palsy, bilateral blindness, deafness, an NFA ICF-CY of >2, a BSDI III cognitive composite score of Results: Among 502 VLBW survivors who completed the 24-month follow-up, 48 (9.6%) presented severe functional disability, of whom 27 had cerebral palsy (5.4%). Rates of severe functional disability and cerebral palsy were higher in neonates with a lower gestational age (p < 0.001). Overall, 147 infants (29.3%) were referred to neuromotor intervention. In the multivariate regression model, gestational age at birth OR 0.79; 95% CI 0.67–0.90; p = 0.001) and periventricular-intraventricular hemorrhage (OR 2.51; 95% CI 1.19–5.26; p = 0.015) were significantly associated with severe functional disability.Conclusion: Neuroprem 2 provides updated information on the neurodevelopmental outcomes of VLBW infants in a large Italian cohort. The overall rate of neurodevelopmental disabilities was quite lower than reported in the previous literature. These data indicate the need for structured follow-up programs from a national neonatal network perspective.

Published
2021

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