1,008 results on '"Neuroectodermal tumor"'
Search Results
2. Conventional and advanced MR imaging findings of primary Ewing sarcoma of the tentorium: a case report with literature review.
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Batur, Abdussamet
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EWING'S sarcoma , *LITERATURE reviews , *MAGNETIC resonance imaging , *NEUROECTODERMAL tumors , *DIFFUSION magnetic resonance imaging , *RETICULUM cell sarcoma , *HYPERPERFUSION - Abstract
Primary intracranial Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) is an extremely uncommon tumor. Care should be taken as it can be mistaken for a meningioma radiologically. This paper reports a case of a 44-year-old male presenting with headache. A magnetic resonance imaging demonstrated a mass involving the tentorium, cerebrum and cerebellum with solid-cystic component. The solid component was hyperintense on T1-weighted images with significant enhancement. There was restriction in diffusion-weighted images and microhemorrhagic signal change in susceptibility weighted images. MR perfusion revealed increased relative cerebral blood volume and mean transit time values. Surgical pathology was reported as ES. Intracranial ES/pPNET is a rare tumor that generally arises from the meninges. It must be distinguished from meningioma since it can be mistaken radiologically, because the treatment and prognosis are quite different. Localization and conventional MR signal characteristics of both lesions are similar. Whereas, MR perfusion findings may be helpful in discrimination. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Common Soft Tissue Tumors
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Sanyal, Riana, Terrano, David, Singh, Rajendra, Phelps, Robert, Smoller, Bruce, editor, and Bagherani, Nooshin, editor
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- 2022
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4. Melanotic Neuroectodermal Tumor Presenting as Endolymphatic Sac Tumor
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Choy, Joseph, Abouzari, Mehdi, Mahboubi, Hossein, Linskey, Mark E, and Djalilian, Hamid R
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Biomedical and Clinical Sciences ,Allied Health and Rehabilitation Science ,Health Sciences ,Clinical Sciences ,Dentistry ,Child ,Ear Neoplasms ,Endolymphatic Sac ,Humans ,Male ,Neuroectodermal Tumor ,Melanotic ,Otorhinolaryngology ,Clinical sciences ,Allied health and rehabilitation science - Published
- 2019
5. Erlotinib in Combination With Temozolomide in Treating Relapsed/Recurrent/Refractory Pediatric Solid Tumors
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- 2019
6. Malignant gastrointestinal neuroectodermal tumor presenting with small intestinal obstruction: A case report
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Makiko Sasaki, Mamoru Tanaka, Koki Asukai, Hiroki Koguchi, Yusuke Inoue, Mizuki Moriyama, Tetsuo Tsukahara, Takeo Kawahara, Eiji Hayashi, Yukinori Hattori, Izumi Hasegawa, and Hiromi Kataoka
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balloon enteroscopy ,clear cell sarcoma ,intestinal obstruction ,neuroectodermal tumor ,small intestine ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Malignant gastrointestinal neuroectodermal tumors (GNETs) are rare malignant mesenchymal neoplasms. To our knowledge, only 99 cases have been reported worldwide. The tumor has an aggressive malignancy, with a rapid progression. The histological features of GNET overlap with those of clear cell sarcoma, which contain Ewing sarcoma breakpoint region 1 mutation. GNETs lack melanocyte‐specific markers, while clear cell sarcoma exhibits melanocytic differentiation. Various symptoms have been reported previously, and the most reported lesion is in the small bowel. The patient was a 69‐year‐old man who presented with abdominal pain and vomiting. Computed tomography revealed a nodule in the small bowel, which induced small intestinal obstruction. Enteroscopic images revealed a submucosal tumor. Surgery was performed, and the patient was diagnosed with GNET. Only two patients whose primary lesions were in the small intestine, including the patient in this report, have undergone enteroscopy before surgery. This is a rare case of GNET in which a patient underwent enteroscopy before surgical treatment.
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- 2022
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7. Melanotic Neuroectodermal Tumor of Infancy, a Rapidly Growing Maxillary Alveolar Mass: A Case Report
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Saede Atarbashi-Moghadam, Ali Lotfi, Mohammad Moshref, and Fazele Atarbashi-Moghadam
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neuroectodermal tumor ,melanotic ,infant ,soft tissue neoplasm ,pigmentation ,Medicine ,Dentistry ,RK1-715 - Abstract
Melanotic neuroectodermal tumor of infancy is a rare, rapidly growing, painless, pigmented neoplasm with neural crest derivation. It usually occurs during the first year of life and there is a prominent predilection for the maxilla. The purpose of the present report is to describe additional case of melanotic neuroectodermal tumor of infancy of maxilla in a 6-month-old infant male. The treatment included surgical excision with safe margins. No attempt was made for immediate grafting of the surgery site due to high proliferation rate of tissues and self-renewal during infancy. The facial growth was normal and the surgical cleft was tightly closed. Due to the rarity of tumor, essential knowledge on characteristics of this lesion would contribute to a proper diagnosis and benefit treatment planning.
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- 2020
8. Melanotic neuroectodermal tumor of infancy: A rare case report
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Tejas Mukund Kulkarni, Deepak J Nagpal, Anagha V Shete, Pratik S Hande, and Mrinal V Shete
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benign tumor ,infancy tumor ,neuroectodermal tumor ,Dentistry ,RK1-715 - Abstract
A rare case melanotic neuroectodermal tumor of infancy occurring in 2-year-old girl affecting left maxilla is described. Computed tomography showed benign expansile type of lesion affecting left maxilla. The lesion was surgically excised completely. Histopathology confirmed the diagnosis of melanotic neuroectodermal tumor. Four months' follow-up showed no recurrence.
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- 2020
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9. Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors
- Published
- 2015
10. A Rare Melanotic Neuroectodermal Tumor of Infancy in a 3-month-old Child: A Case Report.
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Patankar SA, Pawar SR, Sharma R, and Patankar AP
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A rare case of melanotic neuroectodermal tumor of infancy (MNTI) occurring in a 3-month-old male child affecting the left maxilla is described. Computed tomography showed the benign expansile type of lesion affecting the left maxilla. The lesion was surgically excised completely. Histopathology confirmed the diagnosis of melanotic neuroectodermal tumor. Almost 6 months of follow-up showed no recurrence., How to Cite This Article: Patankar SA, Pawar SR, Sharma R, et al. A Rare Melanotic Neuroectodermal Tumor of Infancy in a 3-month-old Child: A Case Report. Int J Clin Pediatr Dent 2024;17(1):79-81., Competing Interests: Source of support: Nil Conflict of interest: None, (Copyright © 2024; The Author(s).)
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- 2024
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11. Melanotic Neuroectodermal Tumor of Infancy, a Rapidly Growing Maxillary Alveolar Mass: A Case Report.
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Atarbashi-Moghadam, Saede, Lotfi, Ali, Moshref, Mohammad, and Atarbashi-Moghadam, Fazele
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ALVEOLAR process surgery ,ALVEOLAR process ,TRANSPLANTATION of organs, tissues, etc. ,DECISION making in clinical medicine ,MAXILLARY tumors ,SYMPTOMS ,HEALTH literacy ,NEUROECTODERMAL tumors - Abstract
Melanotic neuroectodermal tumor of infancy is a rare, rapidly growing, painless, pigmented neoplasm with neural crest derivation. It usually occurs during the first year of life and there is a prominent predilection for the maxilla. The purpose of the present report is to describe additional case of melanotic neuroectodermal tumor of infancy of maxilla in a 6- month-old infant male. The treatment included surgical excision with safe margins. No attempt was made for immediate grafting of the surgery site due to high proliferation rate of tissues and self-renewal during infancy. The facial growth was normal and the surgical cleft was tightly closed. Due to the rarity of tumor, essential knowledge on characteristics of this lesion would contribute to a proper diagnosis and benefit treatment planning. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
12. Adrenal mass of unusual etiology: Ewing sarcoma in a young man
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Levent Soydan, MD, Ali Aslan Demir, MD, Elif Sayman, MD, Burcu Onomay Celik, MD, and Bala Basak Oven Ustaalioglu, MD
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Adrenal gland ,Ewing sarcoma ,Neuroectodermal tumor ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Ewing sarcoma and peripheral primitive neuroectodermal tumor belong to the Ewing sarcoma (ES) family of tumors originating from a primitive neural tube. We report a 31-year-old man who was admitted to the urology clinic with complaints of fever, nausea, and dysuria. A right-sided adrenal mass was detected during ultrasonography. The lesion was then evaluated with magnetic resonance imaging, which showed areas of necrosis amid heterogeneous solid areas. Whole body scan with 2-deoxy-2-[fluorine-18]fluoro-D-glucose integrated with computed tomography and bone scan studies showed pulmonary and osseous metastatic foci. The mass and right kidney were removed by an open approach. An immunohistochemical and molecular workup enabled the diagnosis of ES. The patient also underwent radiotherapy and chemotherapy. The patient remained in fairly good health during the 18-month follow-up period, but showed progression of all metastatic foci and died 26 months after treatment. In conclusion, adrenal ES should be included in the differential diagnosis of nonfunctional adrenal lesions despite its rare occurrence.
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- 2017
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13. Primary Intraspinal Primitive Neuroectodermal Tumor (PNET)
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Eltorai, Ibrahim M. and Eltorai, Ibrahim M.
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- 2016
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14. Valproate and Etoposide for Patients With Neuronal Tumors and Brain Metastases
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- 2012
15. Introduction to Bone Sarcomas
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Papanastassiou, Ioannis D., Demertzis, Nikolaos S., Gouliamos, Athanasios D., editor, Andreou, John, editor, and Kosmidis, Paris, editor
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- 2014
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16. Ewing Sarcoma Family of Tumors
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Kühne, Thomas, Imbach, Paul, editor, Kühne, Thomas, editor, and Arceci, Robert J., editor
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- 2014
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17. Epididymal melanotic neuroectodermal tumor of infancy: A rare cause of scrotal mass in an infant.
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Burton, Kirsteen R., Ngan, Bo-Yee, and Navarro, Oscar M.
- Abstract
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, benign neoplasm of neural crest origin more commonly seen in the craniofacial region. We report a case of MNTI of the epididymis in a 6-month-old male child with emphasis on the sonographic appearance which has not been previously described. In this case, the mass was inseparable from the testicle and therefore the differential diagnosis considered both extratesticular and intratesticular masses. MNTI should be added to the differential diagnosis of scrotal masses, particularly if they present in a child younger than 12 months of age. [ABSTRACT FROM AUTHOR]
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- 2019
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18. Cervicomedullary primitive neuroectodermal tumor of the spine: Case report.
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Nery, Breno, Tângari Pereira, Leandro César, Fernandes Costa, Rodrigo Antônio, Mendes Queiroz, Rodolfo, Giansante Abud, Lucas, Quaggio, Eduardo, Henriques Coronatto, Lígia, Teixeira Prado, Isadora Salviano, Hissae Miyake, Cecília, and Bernardes Filho, Fred
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NEUROECTODERMAL tumors ,MAGNETIC resonance imaging ,TUMOR surgery ,DIAGNOSIS ,CERVICAL vertebrae ,SPINE - Abstract
Background: Intramedullary primitive neuroectodermal tumors (PNETs) are tumors found rarely in the cervical region, with only five such cases described in the literature. The available literature contains only one report regarding cervicomedullary junction PNET. Case Description: The authors present a case report of a 45-year-old male patient who had undergone urgent hospitalization owing to progressive tetraparesis and subtle impairment of respiratory function. He underwent magnetic resonance imaging, which showed an extensive enhancing cervical intramedullary tumor extending from C5 to the bulbar region. Since he developed severe impairment of respiratory function, he required tracheostomy. He then underwent microsurgery 2 days after his admission, and a partial tumor resection was performed. The pathological diagnosis of PNET of the cervicomedullary junction (CMJ) was made. He had slight worsening of strength after surgery with subsequent deterioration over the next 3 weeks. The tumor displayed aggressive growth; thus, radiotherapy was indicated. Unfortunately, he developed severe febrile neutropenia and died after 2 weeks of radiotherapy. Given the rarity of the condition, we wish to review the epidemiology, pathophysiology, and treatment options of his population. Conclusion: Intramedullary PNETs of the cervical spine and CMJ are exceedingly rare in adults; treatment of such patients remains a challenge, despite the modern neurosurgical armamentarium that is available. [ABSTRACT FROM AUTHOR]
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- 2018
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19. The CT and US features of Ewing’s sarcoma/primary neuroectodermal tumor of the kidney: two case reports and review of literature
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Zhang DF, Li ZH, Gao DP, Yang GJ, Ding YY, Wang GS, and Dong XX
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Ewing sarcoma ,neuroectodermal tumor ,X-ray computed,Tomography ,histology ,ultrasound ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Da-Fu Zhang,* Zhen-Hui Li,* De-Pei Gao, Guang-Jun Yang, Ying-Ying Ding, Guan-Shun Wang, Xing-Xiang Dong Department of Radiology, The Third Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, People’s Republic of China *These authors contributed equally to this work Abstract: Ewing’s sarcoma/primary neuroectodermal tumor (EWS/PNET) is an extraordinarily rare primary tumor of the kidney with characteristic histology. To date, the imaging features of EWS/PNET have not been clearly described. Here, we report two cases of EWS/PNET confirmed by fine-needle aspiration biopsy and analyze the findings of computed tomography and ultrasound. The radiological features of EWS/PNET are presented along with a brief review of the pertinent literature to have a further understanding of EWS/PNET’s imaging features. Keywords: Ewing’s sarcoma, neuroectodermal tumor, X-ray computed tomography, histology, ultrasound
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- 2016
20. Prenatal diagnosis of bilateral retinoblastomas by multimodality fetal imaging: case report and review of the literature
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Theresa A. Grebe, Monique Riemann, Patricia Cornejo, Luís F. Gonçalves, Dawn Moncrief, and Aparna Ramasubramanian
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medicine.medical_specialty ,Trilateral retinoblastoma ,Offspring ,Retinal Neoplasms ,Enucleation ,Prenatal diagnosis ,Pineal Gland ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Prenatal Diagnosis ,Fetal mri ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Neuroectodermal tumor ,business.industry ,Retinoblastoma ,Ultrasound ,Infant ,medicine.disease ,Magnetic Resonance Imaging ,eye diseases ,030220 oncology & carcinogenesis ,Female ,Radiology ,business - Abstract
Retinoblastoma is the prototypic genetic tumor. Caused by mutations in the RB1 gene, retinoblastomas are heritable in 40% of the cases and, in such cases, tumors are bilateral in 80%, unilateral in 15%, and trilateral in 5% of the cases. Trilateral retinoblastoma is a term that describes bilateral retinoblastomas plus a midline suprasellar or pineal neuroectodermal tumor. Patients with a germline RB1 mutation have 45% chance of having an offspring with retinoblastoma. Prenatal diagnosis is important because the doubling time is fast, ranging from 7 to 15 days. Thus, late diagnosis during infancy is associated with larger tumors and increased risk of death, need for globe enucleation and vision loss. We report a case of bilateral retinoblastomas diagnosed by targeted high-resolution ultrasonography of the orbits at 32 weeks of gestation in a patient at risk. This report demonstrates the feasibility of accurately detecting even tiny retinoblastomas by ultrasound with current technology. We also review prenatally published cases to date and comment on the technical strengths and limitations of ultrasound and fetal MRI for prenatal diagnosis of retinoblastomas.
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- 2021
21. Tumors and Tumor-Like Conditions of Bones
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Isaacs, Hart, Jr and Isaacs, Hart Jr.
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- 2013
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22. Illustrations
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Oh, Young Taik, Kim, Seung Hyup, and Kim, Seung Hyup, editor
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- 2012
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23. Rare neonatal malignant primary orbital tumors: Three case reports
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Hong-Yang Li, Yan Zhang, Fang He, Hui-Min Zhang, Han-Yang Yu, Yue-Yue Li, and Xiao-Li Xie
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medicine.medical_specialty ,Chemotherapy ,business.industry ,medicine.medical_treatment ,General Medicine ,Newborn ,medicine.disease ,Surgery ,Mass excision ,Treatment ,Radiation therapy ,Characteristics ,Case report ,medicine ,Normal growth ,Presentation (obstetrics) ,Aggressive infantile fibromatosis ,Neuroectodermal tumor ,Rhabdomyosarcoma ,business ,Malignant primary orbital tumors ,Outcome - Abstract
Background Aggressive malignant primary orbital tumors are extremely rare in newborns. The current cases further clarify the clinical features of malignant primary orbital tumors in neonates. Case summary At the time of presentation at the Seventh Center of People's Liberation Army General (PLAG) Hospital, the children were 1-, 2- and 5-mo-old, respectively, and included 2 boys and 1 girl. All three cases had unilateral proptosis at birth, and underwent mass excision and histopathologic examination. A peripheral primary neuroectodermal tumor, an aggressive infantile fibromatosis and an embryonic rhabdomyosarcoma were diagnosed, respectively. The first case underwent routine chemotherapy following surgery but died within three months due to worsening condition as the tumor spread throughout the body. The other two children were treated by surgery, and at the follow-up visits 6 mo and 1 year after surgery, respectively, the wound was completed healed, and they had normal growth and development without radiotherapy or chemotherapy. A review of highly uncommon orbital tumors in newborns is also provided. Conclusion Malignant primary tumors should be considered in the presence of unilateral proptosis in newborns.
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- 2021
24. Primary renal sarcomas: imaging features and discrimination from non-sarcoma renal tumors
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Dominik Geisel, Johannes Uhlig, Michael Köhler, Heike Preibsch, Alexey Surov, Pieter De Visschere, Dominik Schramm, Sophie Bachanek, Matthias May, Michael Puesken, Annemarie Uhlig, Mehmet Ruhi Onur, Marc-André Weber, and Sonja Kinner
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Adult ,medicine.medical_specialty ,Medizin ,Soft Tissue Neoplasms ,Vena Cava, Inferior ,urologic and male genital diseases ,Inferior vena cava ,030218 nuclear medicine & medical imaging ,Renal sarcoma ,03 medical and health sciences ,KIDNEY ,0302 clinical medicine ,medicine.artery ,Machine learning ,Medicine and Health Sciences ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,ddc:610 ,Renal artery ,Neuroectodermal tumor ,Vein ,Neuroradiology ,Kidney ,NEUROECTODERMAL TUMOR ,business.industry ,Sarcoma ,ADULTS ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Kidney Neoplasms ,medicine.anatomical_structure ,Renal cancer ,medicine.vein ,Oncology ,Radiology Nuclear Medicine and imaging ,030220 oncology & carcinogenesis ,Radiological imaging ,Radiology ,Renal vein ,business ,NEOPLASMS - Abstract
Objectives To assess imaging features of primary renal sarcomas in order to better discriminate them from non-sarcoma renal tumors. Methods Adult patients diagnosed with renal sarcomas from 1995 to 2018 were included from 11 European tertiary referral centers (Germany, Belgium, Turkey). Renal sarcomas were 1:4 compared to patients with non-sarcoma renal tumors. CT/MRI findings were assessed using 21 predefined imaging features. A random forest model was trained to predict “renal sarcoma vs. non-sarcoma renal tumors” based on demographics and imaging features. Results n = 34 renal sarcomas were included and compared to n = 136 non-sarcoma renal tumors. Renal sarcomas manifested in younger patients (median 55 vs. 67 years, p < 0.01) and were more complex (high RENAL score complexity 79.4% vs. 25.7%, p < 0.01). Renal sarcomas were larger (median diameter 108 vs. 43 mm, p < 0.01) with irregular shape and ill-defined margins, and more frequently demonstrated invasion of the renal vein or inferior vena cava, tumor necrosis, direct invasion of adjacent organs, and contact to renal artery or vein, compared to non-sarcoma renal tumors (p < 0.05, each). The random forest algorithm yielded a median AUC = 93.8% to predict renal sarcoma histology, with sensitivity, specificity, and positive predictive value of 90.4%, 76.5%, and 93.9%, respectively. Tumor diameter and RENAL score were the most relevant imaging features for renal sarcoma identification. Conclusion Renal sarcomas are rare tumors commonly manifesting as large masses in young patients. A random forest model using demographics and imaging features shows good diagnostic accuracy for discrimination of renal sarcomas from non-sarcoma renal tumors, which might aid in clinical decision-making. Key Points • Renal sarcomas commonly manifest in younger patients as large, complex renal masses. • Compared to non-sarcoma renal tumors, renal sarcomas more frequently demonstrated invasion of the renal vein or inferior vena cava, tumor necrosis, direct invasion of adjacent organs, and contact to renal artery or vein. • Using demographics and standardized imaging features, a random forest showed excellent diagnostic performance for discrimination of sarcoma vs. non-sarcoma renal tumors (AUC = 93.8%, sensitivity = 90.4%, specificity = 76.5%, and PPV = 93.9%).
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- 2021
25. Melanotic neuroectodermal tumor of infancy: A rare case report.
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Kulkarni, Tejas, Nagpal, Deepak, Shete, Anagha, Hande, Pratik, and Shete, Mrinal
- Abstract
A rare case melanotic neuroectodermal tumor of infancy occurring in 2-year-old girl affecting left maxilla is described. Computed tomography showed benign expansile type of lesion affecting left maxilla. The lesion was surgically excised completely. Histopathology confirmed the diagnosis of melanotic neuroectodermal tumor. Four months' follow-up showed no recurrence. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
26. Ewing Sarcoma Family of Tumors
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Kühne, Thomas, Imbach, Paul, editor, Kühne, Thomas, editor, and Arceci, Robert J., editor
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- 2011
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27. Liponeurocytoma of the Cerebellopontine Angle.
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Chiaramonte, Carmela, Rabaste, Sylvain, Jacquesson, Timothee, Meyronet, David, Cotton, François, Jouanneau, Emmanuel, and Berhouma, Moncef
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CEREBELLOPONTILE angle , *MEDULLOBLASTOMA , *NEUROECTODERMAL tumors , *DIAGNOSIS - Abstract
Background Liponeurocytoma is a very rare tumor classified as grade II (neuronal and mixed neuronal-glial tumors) according to 2016 World Health Organization classification of tumors of the central nervous system. The median age at detection is 50 years, and the most frequent location is the posterior cranial fossa, especially within the cerebellar hemispheres; liponeurocytomas arising in the cerebellopontine angle (CPA) are exceptional. Case Description Here we report the clinical, radiological, and pathological characteristics of a CPA liponeurocytoma in a 35-year-old woman, as well as a review of the literature. This unusual cisternal location raises the issue of the differential imaging diagnosis with much more common CPA tumors (e.g., meningiomas, vestibular schwannomas, ependymomas, epidermoid cyst, hemangioblastomas, medulloblastomas). Conclusion To the best of our knowledge, 59 cases of cerebellar liponeurocytomas have been reported to date, which include only 6 cases of CPA liponeurocytomas. Treatment relies on total removal whenever possible, with an excellent prognosis, but a high MIB-1 index (>10%) and/or incomplete tumor resection are the main adverse prognostic factors. [ABSTRACT FROM AUTHOR]
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- 2018
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28. Neuroectodermal Tumor
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Schwab, Manfred, editor
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- 2009
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29. LATE ONSET OF PRIMARY PULMONARY PRIMITIVE NEUROECTODERMAL TUMOR: A CASE REPORT.
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BAŞGÖZ, BILGIN BAHADIR, AYDIN, ADEM, İNCE, SEMRA, DEMİRCİ, İBRAHIM, and ÖZCAN, AYHAN
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NEUROECTODERMAL tumors , *SARCOMA , *CANCER chemotherapy , *PATIENTS - Abstract
Lungs are one of most metastatic areas for primitive neuroectodermal tumor (PNET), however primary pulmonary PNET is extremely rare. Here we present a case of a 58-year-old male patient with a tumor in the right lung that originated from the lung but not from chest wall. Patient was diagnosed with PNET following histological and immunohistochemical examination of CT-guided percutaneous tru-cut needle biopsy and no distant metastasis were detected in PET-CT scan. As advised recently in published literature, surgical resection following neoadjuvant chemotherapy protocol is preferred in the treatment of our patient as it has better success of complete resection leading to higher 5-year survival rates. Although primary pulmonary PNET is uncommon, it should be taken into account and complete surgical resection should be aimed as treatment to achieve higher survival rates. [ABSTRACT FROM AUTHOR]
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- 2017
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30. Neoplasms, Brain, Supratentorial, Pediatric
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TAMD, Huisman, Brehmer, Ulrike, and Baert, Albert L., editor
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- 2008
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31. Neoplasms, Bone, Malignant
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Davies, Mark and Baert, Albert L., editor
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- 2008
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32. Colonic Ganglioneuroma: A Rare Lesion With Extremely Different Presentations and Outcomes in Two Patients
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Masooma Niazi, Bhavna Balar, Hafsa Abbas, Helen Remotti, Ahmed Baiomi, and Myrta Daniel
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Pathology ,medicine.medical_specialty ,Abdominal pain ,Gastrointestinal tract ,Abdominal mass ,Colorectal cancer ,business.industry ,Neuroganglioma ,Case Report ,medicine.disease ,Colon cancer ,Lesion ,medicine ,Rare Lesion ,Ganglioneuroma ,medicine.symptom ,Neuroectodermal tumor ,business - Abstract
Ganglioneuroma (GN) of the gastrointestinal tract is an extremely rare neuroectodermal tumor. Patients with ganglioneuromas have different presentations depending on the location, extent and size of the lesion. We present two cases of ganglioneuromas that had different clinical presentations and outcomes.
- Published
- 2021
33. Prognostic and Therapeutic Targets in the Ewing's Family of Tumors (PROTHETS)
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Picci, P., Scotlandi, K., Serra, M., Rizzi, A., Llombart-Bosch, Antonio, editor, Felipo, Vicente, editor, and López-Guerrero, José Antonio, editor
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- 2006
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34. Primitive Neuroectodermal Tumors and Related Lesions
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Simoens, W. A., Degryse, H. R., De Schepper, Arthur M., editor, Vanhoenacker, Filip, editor, Gielen, Jan, editor, and Parizel, Paul M., editor
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- 2006
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35. Neuroblastoma
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Imbach, Paul, Imbach, Paul, editor, Kühne, Thomas, editor, and Arceci, Robert J., editor
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- 2006
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36. 'Embryonic-type Neuroectodermal Tumor' Should Replace 'Primitive Neuroectodermal Tumor' of the Testis and Gynecologic Tract
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Trevor A Flood, Thomas M. Ulbright, and Michelle S. Hirsch
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Pathology ,medicine.medical_specialty ,Type (biology) ,Primitive neuroectodermal tumor ,medicine ,Surgery ,Anatomy ,Biology ,medicine.disease ,Neuroectodermal tumor ,Nomenclature ,Embryonic stem cell ,Pathology and Forensic Medicine - Published
- 2021
37. Primitive neuroectodermal tumor of the kidney: a rare case
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R. Batra, R. Pandey, P. Dhaigude, and D. Gupta
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medicine.medical_specialty ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,Ewings sarcoma ,Malignancy ,lcsh:RC870-923 ,Nephrectomy ,03 medical and health sciences ,0302 clinical medicine ,Renal cell carcinoma ,Medicine ,Neuroectodermal tumor ,Hematuria ,business.industry ,Primary neuroectodermal tumor (PNET) ,medicine.disease ,lcsh:Diseases of the genitourinary system. Urology ,Left Lumbar Region ,030220 oncology & carcinogenesis ,Primitive neuroectodermal tumor ,Radiology ,Sarcoma ,Differential diagnosis ,business - Abstract
Background Primitive neuroectodermal tumor commonly occurs in bones and is equivalent to Ewing’s sarcoma. Very few cases have been reported in the literature and they had a very different presentation and very aggressive behavior. Case presentation We present a case of a young 23-year-old male who presented with complaints of pain in left lumbar region of abdomen since 8 months and hematuria off and on. CT scan of the abdomen was done which revealed a large heterogeneously enhancing mass lesion in the left lumbar region arising from the superior and mid-pole of left kidney showing multiple non-enhancing necrotic areas. A diagnosis of left renal cell carcinoma was kept. Through the transperitoneal approach, the left kidney was approached and a left radical nephrectomy was done. The histopathology report revealed the tumor cells to be positive for CD99 and focally positive for Vimentin and negative for cytokeratin thereby making a diagnosis of primary neuroectodermal tumor (PNET). Conclusions Renal PNET is a rare renal malignancy that should be kept in the differential diagnosis of a renal SOL especially when it is a presenting feature in adolescent and young adult. It has a very aggressive course and multimodal therapy has to be considered in its treatment
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- 2021
38. Olfactory Neuroblastoma of the Sinonasal Tract with Prominent Orbital Protrusion: A Case Report and Literature Review
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Ying-kun Guo, Jingxin Wang, Zhi-gang Yang, and Lin Chen
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Nasal cavity ,medicine.medical_specialty ,Olfactory Neuroblastoma ,business.industry ,Sinonasal Tract ,Nasal congestion ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Paranasal sinuses ,medicine.anatomical_structure ,Otorhinolaryngology ,Anterior cranial fossa ,030220 oncology & carcinogenesis ,medicine ,Surgery ,Radiology ,medicine.symptom ,business ,Neuroectodermal tumor ,030217 neurology & neurosurgery ,Orbit (anatomy) - Abstract
Olfactory neuroblastoma (ONB) is a rare malignant neuroectodermal tumor of the nasal cavity. Olfactory neuroblastoma centered in the posterior right orbit with prominent orbital protrusion is even rare. Grading ONB is extremely important as individualized treatment plans must be formulated according to tumor grade. We report the case of a 67-year-old female who presented with the chief complaints of persistent nasal congestion with intermittent epistaxis and unilateral proptosis over the past five years. Radiological imaging was suggestive of a large heterogeneous mass in the right superior nasal cavity with extensions into the right medial orbit, nasopharynx, the right maxillary sinus, the anterior cranial fossa, right ethmoidal, frontal and bilateral sphenoidal sinuses, as well as into the right frontal lobe. Assessment of the radiologic features revealed the diagnostic possibility of olfactory neuroblastoma. A nasopharyngeal biopsy confirmed an olfactory neuroblastoma. Frontal osteoplastic craniotomy and excision of the intracranial part of the tumor from above and transnasal endoscopic removal of the mass in the nasal cavities, paranasal sinuses and right medial orbit from below was done. Evaluation of histopathological characteristics and immunohistochemical findings revealed a diagnosis of WHO grade IV olfactory neuroblastoma. Because of poor economic condition, the patient did not take adjuvant radiotherapy and chemoradiation and post-operative examination. We report a huge ONB centered in the posterior right orbit with prominent orbital protrusion. Magnetic resonance image and computed tomography are helpful for evaluating the appearance and the extent of ONB, as well as grading this tumor, which may aid therapeutic decisions and improve survival.
- Published
- 2021
39. Primary Clear Cell Sarcoma of the Ileum: A Case Report With Next-Generation Sequencing Analysis
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Long Zhang, Ke Bi, Yu Zeng, Yunjin Wu, Tingting Zhang, Peipei Zhu, Xianghua Yi, Xue Chen, Haoyang Zhang, and Dandan Huang
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Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Oncogene Proteins, Fusion ,SOX10 ,Biology ,S100 protein ,Pathology and Forensic Medicine ,Fusion gene ,03 medical and health sciences ,0302 clinical medicine ,Ileum ,medicine ,Humans ,Neuroectodermal tumor ,Aged ,Activating Transcription Factor 1 ,Gene Rearrangement ,medicine.diagnostic_test ,fungi ,High-Throughput Nucleotide Sequencing ,Exons ,medicine.disease ,Ileal Neoplasms ,030104 developmental biology ,030220 oncology & carcinogenesis ,Surgery ,Sarcoma, Clear Cell ,Clear-cell sarcoma ,RNA-Binding Protein EWS ,Anatomy ,Tomography, X-Ray Computed ,Epithelioid cell ,Clear cell ,Fluorescence in situ hybridization - Abstract
As the concept of clear cell sarcoma–like tumor or malignant gastrointestinal neuroectodermal tumor (CCS-LT/MGNET) has been widely accepted, primary CCS of the gastrointestinal tract (CCS-GI) is becoming a rare entity. In this article, we describe a case of primary CCS-GI that occurred in the ileum of a 65-year-old male to further illustrate its rare occurrence. Similar to CCS of soft tissue (CCS-ST), the tumor was composed of spindled to epithelioid cells displaying fascicular, nested, or pseudopapillary arrangement. The tumor cells had large round to ovoid nuclei with vesicular chromatin and prominent nucleoli, containing eosinophilic to pale cytoplasm. In contrast to CCS-LT/MGNET, immunohistochemical study also showed variable positivity of HMB45, melan A, and MiTF besides the strong and diffuse staining of S100 protein and SOX10. Fluorescence in situ hybridization (FISH) using fusion probes identified EWSR1 and ATF1 genes rearrangement. Next-generation sequencing (NGS) analysis further revealed EWSR1 exons9/8- ATF1 exon4 and ATF1 exon3- EWSR1 exon11 fusion genes. CCS-GI and CCS-LT/MGNET possibly represent 2 related entities of the same spectrum, which differentiate along 2 different pathways.
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- 2021
40. Conventional and advanced MR imaging findings of primary Ewing sarcoma of the tentorium: a case report with literature review
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Abdussamet Batur
- Subjects
Pathology ,medicine.medical_specialty ,Mr perfusion ,business.industry ,food and beverages ,General Medicine ,medicine.disease ,Mr imaging ,Tentorium ,Meningioma ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Primitive neuroectodermal tumor ,medicine ,Surgery ,Neurology (clinical) ,Sarcoma ,Neuroectodermal tumor ,business ,030217 neurology & neurosurgery - Abstract
Primary intracranial Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) is an extremely uncommon tumor. Care should be taken as it can be mistaken for a meningioma radiologically.This paper reports a case of a 44-year-old male presenting with headache. A magnetic resonance imaging demonstrated a mass involving the tentorium, cerebrum and cerebellum with solid-cystic component. The solid component was hyperintense on T1-weighted images with significant enhancement. There was restriction in diffusion-weighted images and microhemorrhagic signal change in susceptibility weighted images. MR perfusion revealed increased relative cerebral blood volume and mean transit time values. Surgical pathology was reported as ES.Intracranial ES/pPNET is a rare tumor that generally arises from the meninges. It must be distinguished from meningioma since it can be mistaken radiologically, because the treatment and prognosis are quite different. Localization and conventional MR signal characteristics of both lesions are similar. Whereas, MR perfusion findings may be helpful in discrimination.
- Published
- 2021
41. Calvarial Melanotic Neuroectodermal Tumor of Infancy with Rhabdomyosarcomatous differentiation—A Rare Case
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Sameer Bakhshi, Sandeep Bohara, Jeyaseelan Nadarajah, Manmohan Singh, Vaishali Suri, Ajay Garg, Leve Joseph Devaranjan Sebastian, and Kanwaljeet Garg
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education.field_of_study ,medicine.medical_specialty ,Chemotherapy ,Open biopsy ,business.industry ,medicine.medical_treatment ,Melanotic neuroectodermal tumor of infancy ,Population ,medicine.disease ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Medicine ,Surgery ,Histopathology ,Neurology (clinical) ,Radiology ,medicine.symptom ,business ,education ,Neuroectodermal tumor ,030217 neurology & neurosurgery ,Craniotomy - Abstract
Background Malignant neuroectodermal tumor of infancy is a rare neural crest cell-derived neoplasm of infants. Histologically, melanotic neuroectodermal tumor of infancy usually consists of 2 types of cells: neuroblast-like and melanocyte-like cells. Here we present a rare case of melanotic neuroectodermal tumor of infancy containing a third type of cell population, that is, rhabdomyoblasts in addition to the above two. Case Description We report a case of a 10-month-old female child who was brought to us with complaints of swelling over the right forehead for the last 9 months, which started increasing in size rapidly 3 months before presenting to us. Noncontrast computed tomography scan showed a large well-defined extra-axial lesion in the right frontotemporal region. The child underwent an open biopsy under general anesthesia. Histopathological sections showed a malignant small round cell tumor consisting of hyperchromatic cells lying in sheets and lobules separated by fibrous septae. The patient underwent 7 cycles of neoadjuvant chemotherapy over a period of 2 months. The patient underwent right frontotemporal craniotomy and gross total excision of the lesion as a definitive surgery. Postoperatively, the patient was stable, and there was no new deficit. Histopathology revealed neuroblast-like and melanocyte-like cells with rhabdomyosarcomatous differentiation. The patient received chemotherapy in the postoperative period. The patient had recurrence of the tumor and died 8 months after the surgery. Conclusions Calvarial malignant neuroectodermal tumor of infancy with rhabdomyosarcomatous differentiation is a rare entity with no cases being reported before. Neoadjuvant chemotherapy with surgical excision can be a promising modality of treatment.
- Published
- 2021
42. Late Intramedullary Spinal Metastases from Esthesioneuroblastoma: Case Report and Prognostic Implications
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Filippo Maria Fava, Francesca Ruggiero, Laura Moschettoni, Adolfo De Luna, and Pierpaolo Lunardi
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medicine.medical_specialty ,medicine.diagnostic_test ,Olfactory Neuroblastoma ,business.industry ,medicine.medical_treatment ,Magnetic resonance imaging ,medicine.disease ,Spinal cord ,Radiation therapy ,03 medical and health sciences ,0302 clinical medicine ,Lumbar ,medicine.anatomical_structure ,Esthesioneuroblastoma ,030220 oncology & carcinogenesis ,medicine ,Surgery ,Neurology (clinical) ,Radiology ,business ,Neuroectodermal tumor ,030217 neurology & neurosurgery ,Rare disease - Abstract
Background Esthesioneuroblastoma (ENB) is an uncommon neuroectodermal tumor that originates from the olfactory mucosa and often recurs locally. Distant metastases of ENB have been described, but there are few reports of intramedullary metastases to the spinal cord. Case Description Here we report a case of a patient presenting with a progressive paraparesis and magnetic resonance imaging findings of multiple drop metastases to thoracic and lumbar regions of the spinal cord, 17 years after diagnosis and treatment for an intracranial ENB with subsequent neck nodal metastases. The dorsal symptomatic lesion was treated with resection, radiotherapy, and adjuvant chemotherapy. The implications of spinal metastases for the clinical prognosis of this disease are discussed, with a review of the few reported cases of spinal ENB metastases in the literature. Conclusions Through the presentation of this case we hope to further contribute to a better understanding of this rare disease's prognosis.
- Published
- 2021
43. Computer Simulation on Morphogenesis of Colonic Neoplasia
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Miyazima, Sasuke, Ono, Kenzo, Nagamine, Tomomasa, Sekimura, Toshio, editor, Noji, Sumihare, editor, Ueno, Naoto, editor, and Maini, Philip K., editor
- Published
- 2003
- Full Text
- View/download PDF
44. Neuroectodermal Tumor
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Schwab, Manfred, editor
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- 2017
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45. Primitive Neuroectodermal Tumors and Related Lesions
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Simoens, W. A., Degryse, H. R., De Schepper, Arthur M., editor, Parizel, Paul M., editor, De Beuckeleer, Luc, editor, and Vanhoenacker, Filip, editor
- Published
- 2001
- Full Text
- View/download PDF
46. Technical Remarks
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Dallenbach-Hellweg, Gisela, Schmidt, Dietmar, Dallenbach, Friederike, Dallenbach-Hellweg, Gisela, Schmidt, Dietmar, and Dallenbach, Friederike
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- 2010
- Full Text
- View/download PDF
47. Mandibular melanotic neuroectodermal tumor of infancy: a role for neoadjuvant chemotherapy.
- Author
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Maroun, Christopher, Khalifeh, Ibrahim, Alam, Elie, Akl, Pierre, Saab, Raya, and Moukarbel, Roger
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NEUROECTODERMAL tumors , *CANCER chemotherapy , *CANCER treatment , *TUMOR treatment ,CENTRAL nervous system tumors - Abstract
Melanotic Neuroectodermal Tumor of Infancy (MNTI) is a rare, locally aggressive neoplasm with a predilection for the head and neck area, most commonly occurring in the maxilla. The vast majority of treatment modalities for all cases of MNTI to date have involved surgical intervention only, with just 9.6 % involving some sort of chemotherapy, radiotherapy, or a combination of the prior mentioned modalities. There is very limited information available regarding the use of neoadjuvant chemotherapy, due to its rare nature. In this report, a 4 month old girl presented to our clinic with a chief complaint of a large oral mass of about 2.5 months in duration. Intraoral examination showed an oral mass arising from the lingual aspect of inferior alveolar ridge with extensive mandibular invasion. The patient received three cycles of vincristine, Adriamycin, and cyclophosphamide as neodajuvant therapy. Upon completion, the tumor had decreased significantly in size. The patient was then scheduled for surgery and underwent surgical resection of the tumor. We were able to obtain adequate shrinkage of the tumor to allow better resectability, easier surgical access and a more minimally invasive approach with no lip split and a smaller neck incision. In conclusion, we have reported an extremely rare case of MNTI of the mandible that was successfully treated with neoadjuvant chemotherapy and surgical resection. This approach was advantageous to minimize the chance of recurrence and improve resectability in particularly large tumors, while maximizing functional outcomes and minimizing deformity. [ABSTRACT FROM AUTHOR]
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- 2016
- Full Text
- View/download PDF
48. Malignant gastrointestinal neuroectodermal tumor in the small intestine with liver metastasis: First case report worldwide
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Taige Chen, Xiaofan Lu, Yang Wang, and Bing Zhang
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Pathology ,medicine.medical_specialty ,Small intestine computed tomography enterography ,business.industry ,lcsh:Surgery ,lcsh:RD1-811 ,medicine.disease ,Small intestine ,Metastasis ,medicine.anatomical_structure ,Malignant gastrointestinal neuroectodermal tumor ,EWSRI detection ,Medicine ,Surgery ,business ,Neuroectodermal tumor ,Liver metastasis - Published
- 2020
49. Primitive neuroectodermal tumor (PNET)/Ewing sarcoma of kidney: A rare case report of three cases
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Anitha Padmanabhan, Nitin M Gadgil, and Rucha K Kanhe
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Pathology ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,CD99 ,Wilms' tumor ,medicine.disease ,Nephrectomy ,Primitive neuroectodermal tumor ,Neuroblastoma ,medicine ,Sarcoma ,Differential diagnosis ,business ,Neuroectodermal tumor - Abstract
Introduction: Primitive neuroectodermal tumor (PNET) / Ewing sarcoma of kidney are rare aggressive tumor with poor prognosis. It occurs in young adults generally in 2nd to 3rd decade of life Case Reports: We report three cases of PNET/Ewing sarcoma of kidney in patients of age 25and 35 years with complain of hematuria and abdominal pain .CT scan revealed heterogeneously enhancing lesion in kidney and we received radical nephrectomy specimen with variegated appearance on gross. Microscopic examination showed tumor with malignant cells in sheets and pseudorosettes .The diagnosis was given as PNET/ES and was confirmed with immunohistochemistry. Discussion: Renal PNET/ES is a member of Ewing sarcoma family. They are rare tumor originating from the neural crest and are more aggressive than PNET at any other site. The presence of Homer Wright rosettes is less common in extra-osseous Ewing sarcoma and their presence is a sure diagnosis of PNET/ES. The differential diagnosis for these small round cell tumor of kidney other than PNET include malignant lymphoma, renal neuroblastoma,,embryonalrhanbdomyosarcoma, wilms tumor. The immunohistochemical marker CD99 positivity is diagnostic. Other markers positive are S-100, vimentin and NSE (neuron specific enolase). Conclusion: Histopathology and immunohistochemistry remains gold standard for confirming the diagnosis. Keywords: Ewing sarcoma (ES) / kidney/, Primitive neuroectodermal tumor, (PNET).
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- 2020
50. Rhabdomyosarcoma of the Adult Prostate
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EXPRESSION ,prostate ,EMBRYONAL RHABDOMYOSARCOMA ,NEUROECTODERMAL TUMOR ,adults ,SPECIALIZED STROMAL TUMORS ,next-generation sequencing ,rhabdomyosarcoma ,BLADDER ,SOLITARY FIBROUS TUMOR ,EPITHELIOID ANGIOSARCOMA ,SARCOMA - Abstract
Primary rhabdomyosarcoma (RMS) of the adult prostate is a very rare tumor with only 45 cases published to date. The clinical course of RMS of the prostate is very aggressive, and prognosis is very poor. Here we describe two cases of primary RMS of the prostate of adult patients and discuss the differential diagnosis of RMS with other mesenchymal tumors of prostate. The first patient was a 50-year-old man who clinically presented with urinary retention and hematuria, low serum prostate-specific antigen, moderate prostatomegaly, and multiple metastases as shown by computed tomography. Histological examination revealed a diffuse "small round blue cell" proliferation with an intermingled population of larger cells with rhabdomyoblastic differentiation that showed immunoreactivity for desmin and MYF4 (myogenin). Molecular and cytogenetic studies did not reveal recurrent chromosomal translocations associated with RMSs and other sarcomas. The patient underwent doxorubicin (adriamycin) treatment without disease progression during the whole follow-up period of 7 months. The second patient was a 39-year-old man who presented with urinary retention, an increased serum prostate-specific antigen level, extensive prostatomegaly, enlarged abdominal and inguinal lymph nodes, and skeletal metastases. Histological examination revealed a tumoral proliferation with a small round blue aspect and diffuse immunoreactivity for desmin and MYF4 (myogenin). Fluorescence in situ hybridization revealed a FOXO1 translocation, consistent with a diagnosis of alveolar-type RMS. The patient followed a multimodal treatment and died of the disease after its progression.
- Published
- 2020
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