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17. Superior vena cava syndrome associated with lymphoma

Author

Yellin, Alon, Mandel, Matilda, Rechavi, Gideon, Neuman, Yoram, Ramot, Bracha, and Lieberman, Yair

Subjects
Superior vena cava syndrome -- Diagnosis, Lymphomas, Tumors in children -- Care and treatment, Family and marriage, Health
Abstract

* Objective.--To evaluate the workup and treatment of children with lymphoma and superior vena cava syndrome. Design.--A retrospective survey. Setting.--State hospital serving as a secondary and tertiary referral center for pediatric oncology and pediatric cardiac surgery. Participants.--Eleven children aged 11 months to 12 years diagnosed as having lymphoma or T-cell acute lymphoblastic leukemia who presented with superior vena cava syndrome during an 11 -year period. Interventions.--Lymph node biopsy (two patients), thoracenthesis (five patients), bone marrow aspiration (two patients), and thoracenthesis in addition to bone marrow aspiration (two patients). All aspirates were evaluated with immunohistochemical studies. Chemotherapy was the only management intervention. Results.--T-cell lymphoma or leukemia accounted for nine cases and Hodgkin's disease for two cases. Respiratory symptoms occurred in 10 patients, including tracheal compression in six patients (compression was life-threatening in one patient). Diagnosis of superior vena cava syndrome was achieved in eight patients using surface-marker analysis of aspirates. The syndrome disappeared within 2 to 10 days. Seven of nine children whose conditions were diagnosed more than 1 year before this writing were alive and free of disease after mean follow-up of 37 months. Conclusions.--(1) A specific diagnosis can be achieved in most children with superior vena cava syndrome and lymphoma, (2) Thoracic computed tomographic scans are essential, identifying minute pleural effusions that can aid diagnosis; (3) Anesthetic hazard is related only to severe tracheal compression; (4) Chemotherapy achieves excellent symptomatic relief, and (5) Long-term survival, without disease, is achievable. (AJDC. 1992;146:1060-1063)

Published
1992

21. Familial clustering of malignant germ cell tumors and Langerhans' histiocytosis

Author

Mandel, Mathida, Toren, Amos, Kende, George, Neuman, Yoram, Kenet, Gilli, and Rechavi, Gideon

Subjects
Germ cell tumors -- Genetic aspects, Familial diseases -- Genetic aspects, Reticuloendotheliosis -- Genetic aspects, Health
Abstract

Three sisters in a family with seven children whose grandmother had an ovarian embryonal carcinoma experienced development of malignant and a malignant-like situation in childhood. Two were diagnosed as having malignant germ cell tumors of the ovary, and the third was found to have Langerhans' histiocytosis. The two girls with germ cell tumor shared an identical human leukocyte antigen, whereas the sister with histiocytosis shared one identical haplotype with them. All three children have been treated successfully with chemotherapy and are doing well off of treatment. Cancer 1994; 73:1980-3. Key words: family cancer syndrome, germ cell tumor, human lymphocyte antigen, Langerhans' histiocytosis.

Published
1994

22. Acute renal failure following intravenous streptokinase infusion for acute myocardial infarction

Author

Birnbaum, Yochai, Strasberg, Boris, Rechavia, Eldad, Neuman, Yoram, and Stahl, Bracha

Subjects
Heart attack -- Drug therapy -- Complications and side effects -- Diagnosis, Streptokinase -- Complications and side effects, Acute renal failure -- Diagnosis -- Complications and side effects -- Drug therapy, Health
Abstract

Streptokinase, Administered either intravenously or by the intracoronary route, is one of the drugs most frequently used for thrombolysis in acute myocardial infarction. Acute renal failure is a relatively rare [...]

Published
1993

26. Increased hypoxemia in patients with COPD and pulmonary hypertension undergoing bronchoscopy with biopsy

Author

Neuman,Yoram, Koslow,Matthew, Matveychuk,Alona, Bar-Sef,Avigdor, Guber,Alexander, Shitrit,David, Neuman,Yoram, Koslow,Matthew, Matveychuk,Alona, Bar-Sef,Avigdor, Guber,Alexander, and Shitrit,David

Abstract

Yoram Neuman,1,3 Matthew Koslow,2,3 Alona Matveychuk,2,3 Avigdor Bar-Sef,1 Alexander Guber,2,3 David Shitrit2,3 1Division of Cardiology, 2Pulmonary Department, Meir Medical Center, Kfar Saba, Israel; 3Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Background and objective: Patients with pulmonary hypertension (PH) are considered to be at risk for complications associated with flexible bronchoscopy (FB), but data concerning the degree of PH are often lacking. We investigated whether COPD patients with PH who undergo bronchoscopy are at greater risk for complications. Methods: This prospective study included 207 consecutive COPD patients undergoing FB. All underwent an echo-Doppler to evaluate pulmonary artery pressure on the day of the bronchoscopy procedure. Pulmonologists were blinded to the echocardiogram results. Results: A total of 167 patients (80.7%) had normal pulmonary pressure. The remaining 40 patients (19.3%) had PH: 27 (13.0%) mild, eight (3.9%) moderate, and five (2.4%) severe. Noninvasive hemodynamic parameters between groups before and after FB were similar. Two patients with normal pulmonary pressure developed supraventricular tachycardia. None developed hemodynamically significant dysrhythmia. Bleeding episodes between groups in bronchoalveolar lavage (BAL) and transbronchial biopsy (TBB) did not differ. PH patients who underwent BAL and TBB had decreased O2 saturation during the procedure compared with the non-PH group (23.5% vs 6.9%, P=0.033). No deaths were attributable to FB. Conclusion: PH is common among COPD patients undergoing FB. PH patients undergoing BAL and TBB are at higher risk of decreased O2 saturation than those without PH. Further studies should assess the risk among COPD patients with moderate-to-severe PH. Keywords: bronchoscopy, hypoxemia, pulmonary hypertension

Published
2015

29. Admission plasma glucose levels within the normal to mildly impaired range and the outcome of patients with acute coronary syndrome

Author

Buturlin, Kirill, Minha, Saar, Rozenbaum, Zach, Neuman, Yoram, Shlezinger, Meital, Goldenberg, Ilan, Mosseri, Morris, and Pereg, David

Abstract

Background: Elevated admission plasma glucose levels >140 mg/dl are associated with adverse clinical outcomes in both diabetic and non-diabetic patients admitted with acute coronary syndrome (ACS). We aimed to evaluate the association between admission plasma glucose levels <140 mg/dl and the outcome of non-diabetic patients admitted with acute coronary syndrome.Methods: The study population consisted of patients with acute coronary syndrome included in the Acute Coronary Syndrome Israeli Survey during 2000–2013. Diabetic patients were excluded. The primary endpoint was all-cause mortality at one year.Results: The 4520patients had a mean age of 61.7±13.5 years and were stratified into four quartiles according to admission plasma glucose (60–94, 95–105, 106–119, 120–140 mg/dl). Patients with higher admission plasma glucose were older and included a higher percentage of smokers. In addition, the higher the glucose so also did they have a poorer risk factor profile including a higher body mass index, total and low-density lipoprotein cholesterol and triglyceride levels, and lower high-density lipoprotein cholesterol levels. During the first year 5.2% of patients died. A comparison of one-year mortality according to admission plasma glucose quartiles demonstrated a significant and progressive increase in mortality risk as admission plasma glucose rose (3.5%, 4.1%, 6.1%, 6.4%, respectively, p=0.001). However, this association lost its clinical significance following a multivariate analysis (p=0.08).Conclusions: High admission plasma glucose levels within the normal to mildly impaired range are associated with increased one-year mortality in non-diabetic acute coronary syndrome patients. However, the higher glucose level is probably not the cause for the adverse outcome but rather a marker for high risk. Our findings support the definition of 140 mg/dl as the cutoff for clinically acceptable admission glucose levels in patients with acute coronary syndrome.

Published
2017
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34. Comparison of frequency of left ventricular wall motion abnormalities in patients with a first acute myocardial infarction with versus without left ventricular hypertrophy

Author

Neuman, Yoram, primary, Cercek, Bojan, additional, Aragon, Joseph, additional, Lee, Steve, additional, Kobal, Sergio, additional, Miyamoto, Takashi, additional, Luo, Huai, additional, Tolstrup, Kirsten, additional, Naqvi, Tasneem Z., additional, Birnbaum, Yochai, additional, and Siegel, Robert J., additional

Published
2004
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39. Correlation of echo-Doppler aortic valve regurgitation index with angiographic aortic regurgitation severity

Author

Chen, Ming, primary, Luo, Huai, additional, Miyamoto, Takashi, additional, Atar, Shaul, additional, Kobal, Sergio, additional, Rahban, Masoud, additional, Brasch, Andrea V., additional, Makkar, Rajendra, additional, Neuman, Yoram, additional, Naqvi, Tasneem Z., additional, Tolstrup, Kirsten, additional, and Siegel, Robert J., additional

Published
2003
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40. Coronary vasodilation by noninvasive transcutaneous ultrasound

Author

Miyamoto, Takashi, primary, Neuman, Yoram, additional, Luo, Huai, additional, Jeon, Doo-Soo, additional, Kobal, Sergio, additional, Ikeno, Fumiaki, additional, Horzewski, Michael, additional, Honda, Yasuhiro, additional, Mirocha, James M, additional, Iwami, Takahiro, additional, Echt, Debra, additional, Fishbein, Michael C, additional, and Siegel, Robert J, additional

Published
2003
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46. Increased Expression of Neutrophil and Monocyte Adhesion Molecules LFA-1 and Mac-1 and Their Ligand ICAM-1 and VLA-4 Throughout the Acute Phase of Myocardial Infarction Possible Implications for Leukocyte Aggregation and Microvascular Plugging

Author

Meisel, Simcha R., Shapiro, Hava, Radnay, Judith, Neuman, Yoram, Khaskia, Abdul-Rahim, Gruener, Nachman, Pauzner, Hana, and David, Daniel

Abstract

Objectives. This study sought to evaluate expression of adhesion molecules on neutrophils and monocytes throughout the acute phase of myocardial infarction.Background. Neutrophil and monocyte counts increase within days from onset of acute myocardial infarction. Because leukocytes are recruited to the involved myocardial region, we postulated that these activated cells would display an increased expression of adhesion molecules necessary for effective endothelial transmigration.Methods. We measured the expression of neutrophil and monocyte lymphocyte function associated antigen-1 (LFA-1), Mac-1, very late after activation antigen-4 (VLA-4) and intercellular adhesion molecule-1 (ICAM-1) by flow cytometry throughout the acute phase of acute myocardial infarction in 25 patients and 10 age-matched control subjects.Results. Expression of Mac-1 on neutrophils increased significantly, whereas no expression of VLA-4 and ICAM-1 was detected. The expression of LFA-1, Mac-1, VLA-4 and ICAM-1 on the monocyte cell membrane in patients with an acute myocardial infarction was increased compared with that in control subjects by 22% (on day 7), 67%, 13% and 44% (all on day 4), respectively (all p < 0.001). Elevated density of monocyte-specific CD14 in the AMI versus the control group was also shown (30%, p < 0.001).Conclusions. Increased expression of neutrophil and monocyte adhesion molecules may contribute to their adhesion to endothelium in the ischemic territory. This adhesion could feasibly precipitate vasoconstriction or add a local thrombotic effect due to tissue factor expression secondary to Mac-1 engagement. In addition, the manifestation of increased density of LFA-1 and Mac-1 by activated leukocytes with monocytes also expressing ICAM-1 suggests that leukocytes may form microaggregates that could cause microvascular plugging. This mechanism may facilitate the occurrence of the “no-reflow” phenomenon or slow coronary filling after acute myocardial infarction.

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49. Uremic Pericarditis.

Author

Feldman, Viktor, Dovrish, Zamir, Weisenberg, Noemi, Neuman, Yoram, and Amital, Howard

Published
2011

50. 1016-152 Rebirth of bedside cardiovascular examination using hand-carried ultrasound.

Author

Kobal, Sergio L, Trento, Luca, Baharami, Simin, Tolstrup, Kirsten, Naqvi, Tasneem Z, Cercek, Bojan, Neuman, Yoram, Mirocha, James, Kar, Saibal, Forrester, James S, and Siegel, Robert J

Subjects
*CARDIOVASCULAR disease diagnosis, *ECHOCARDIOGRAPHY, *POINT-of-care testing, *CARDIAC pacing, *IMAGE quality in diagnostic ultrasonic imaging, *RANDOMIZED controlled trials
Published
2004
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