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2. Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design

Author

Horwitz, Leora I., primary, Thaweethai, Tanayott, additional, Brosnahan, Shari B., additional, Cicek, Mine S., additional, Fitzgerald, Megan L., additional, Goldman, Jason D., additional, Hess, Rachel, additional, Hodder, S. L., additional, Jacoby, Vanessa L., additional, Jordan, Michael R., additional, Krishnan, Jerry A., additional, Laiyemo, Adeyinka O., additional, Metz, Torri D., additional, Nichols, Lauren, additional, Patzer, Rachel E., additional, Sekar, Anisha, additional, Singer, Nora G., additional, Stiles, Lauren E., additional, Taylor, Barbara S., additional, Ahmed, Shifa, additional, Algren, Heather A., additional, Anglin, Khamal, additional, Aponte-Soto, Lisa, additional, Ashktorab, Hassan, additional, Bassett, Ingrid V., additional, Bedi, Brahmchetna, additional, Bhadelia, Nahid, additional, Bime, Christian, additional, Bind, Marie-Abele C., additional, Black, Lora J., additional, Blomkalns, Andra L., additional, Brim, Hassan, additional, Castro, Mario, additional, Chan, James, additional, Charney, Alexander W., additional, Chen, Benjamin K., additional, Chen, Li Qing, additional, Chen, Peter, additional, Chestek, David, additional, Chibnik, Lori B., additional, Chow, Dominic C., additional, Chu, Helen Y., additional, Clifton, Rebecca G., additional, Collins, Shelby, additional, Costantine, Maged M., additional, Cribbs, Sushma K., additional, Deeks, Steven G., additional, Dickinson, John D., additional, Donohue, Sarah E., additional, Durstenfeld, Matthew S., additional, Emery, Ivette F., additional, Erlandson, Kristine M., additional, Facelli, Julio C., additional, Farah-Abraham, Rachael, additional, Finn, Aloke V., additional, Fischer, Melinda S., additional, Flaherman, Valerie J., additional, Fleurimont, Judes, additional, Fonseca, Vivian, additional, Gallagher, Emily J., additional, Gander, Jennifer C., additional, Gennaro, Maria Laura, additional, Gibson, Kelly S., additional, Go, Minjoung, additional, Goodman, Steven N., additional, Granger, Joey P., additional, Greenway, Frank L., additional, Hafner, John W., additional, Han, Jenny E., additional, Harkins, Michelle S., additional, Hauser, Kristine S. P., additional, Heath, James R., additional, Hernandez, Carla R., additional, Ho, On, additional, Hoffman, Matthew K., additional, Hoover, Susan E., additional, Horowitz, Carol R., additional, Hsu, Harvey, additional, Hsue, Priscilla Y., additional, Hughes, Brenna L., additional, Jagannathan, Prasanna, additional, James, Judith A., additional, John, Janice, additional, Jolley, Sarah, additional, Judd, S. E., additional, Juskowich, Joy J., additional, Kanjilal, Diane G., additional, Karlson, Elizabeth W., additional, Katz, Stuart D., additional, Kelly, J. Daniel, additional, Kelly, Sara W., additional, Kim, Arthur Y., additional, Kirwan, John P., additional, Knox, Kenneth S., additional, Kumar, Andre, additional, Lamendola-Essel, Michelle F., additional, Lanca, Margaret, additional, Lee-lannotti, Joyce K., additional, Lefebvre, R. Craig, additional, Levy, Bruce D., additional, Lin, Janet Y., additional, Logarbo, Brian P., additional, Logue, Jennifer K., additional, Longo, Michele T., additional, Luciano, Carlos A., additional, Lutrick, Karen, additional, Malakooti, Shahdi K., additional, Mallett, Gail, additional, Maranga, Gabrielle, additional, Marathe, Jai G., additional, Marconi, Vincent C., additional, Marshall, Gailen D., additional, Martin, Christopher F., additional, Martin, Jeffrey N., additional, May, Heidi T., additional, McComsey, Grace A., additional, McDonald, Dylan, additional, Mendez-Figueroa, Hector, additional, Miele, Lucio, additional, Mittleman, Murray A., additional, Mohandas, Sindhu, additional, Mouchati, Christian, additional, Mullington, Janet M., additional, Nadkarni, Girish N., additional, Nahin, Erica R., additional, Neuman, Robert B., additional, Newman, Lisa T., additional, Nguyen, Amber, additional, Nikolich, Janko Z., additional, Ofotokun, Igho, additional, Ogbogu, Princess U., additional, Palatnik, Anna, additional, Palomares, Kristy T. S., additional, Parimon, Tanyalak, additional, Parry, Samuel, additional, Parthasarathy, Sairam, additional, Patterson, Thomas F., additional, Pearman, Ann, additional, Peluso, Michael J., additional, Pemu, Priscilla, additional, Pettker, Christian M., additional, Plunkett, Beth A., additional, Pogreba-Brown, Kristen, additional, Poppas, Athena, additional, Porterfield, J. Zachary, additional, Quigley, John G., additional, Quinn, Davin K., additional, Raissy, Hengameh, additional, Rebello, Candida J., additional, Reddy, Uma M., additional, Reece, Rebecca, additional, Reeder, Harrison T., additional, Rischard, Franz P., additional, Rosas, Johana M., additional, Rosen, Clifford J., additional, Rouphael, Nadine G., additional, Rouse, Dwight J., additional, Ruff, Adam M., additional, Saint Jean, Christina, additional, Sandoval, Grecio J., additional, Santana, Jorge L., additional, Schlater, Shannon M., additional, Sciurba, Frank C., additional, Selvaggi, Caitlin, additional, Seshadri, Sudha, additional, Sesso, Howard D., additional, Shah, Dimpy P., additional, Shemesh, Eyal, additional, Sherif, Zaki A., additional, Shinnick, Daniel J., additional, Simhan, Hyagriv N., additional, Singh, Upinder, additional, Sowles, Amber, additional, Subbian, Vignesh, additional, Sun, Jun, additional, Suthar, Mehul S., additional, Teunis, Larissa J., additional, Thorp, John M., additional, Ticotsky, Amberly, additional, Tita, Alan T. N., additional, Tragus, Robin, additional, Tuttle, Katherine R., additional, Urdaneta, Alfredo E., additional, Utz, P. J., additional, VanWagoner, Timothy M., additional, Vasey, Andrew, additional, Vernon, Suzanne D., additional, Vidal, Crystal, additional, Walker, Tiffany, additional, Ward, Honorine D., additional, Warren, David E., additional, Weeks, Ryan M., additional, Weiner, Steven J., additional, Weyer, Jordan C., additional, Wheeler, Jennifer L., additional, Whiteheart, Sidney W., additional, Wiley, Zanthia, additional, Williams, Natasha J., additional, Wisnivesky, Juan P., additional, Wood, John C., additional, Yee, Lynn M., additional, Young, Natalie M., additional, Zisis, Sokratis N., additional, and Foulkes, Andrea S., additional

Published
2023
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6. Arenig volcanic and sedimentary strata, central New Brunswick and eastern Maine

Author

Poole, W.H. and Neuman, Robert B.

Subjects
Maine -- Natural history, New Brunswick -- Natural history, Geology, Stratigraphic -- Research, Volcanic ash, tuff, etc. -- Composition -- Structure -- Research, Sediments (Geology) -- Composition -- Structure -- Research, Earth sciences, Structure, Composition, Research, Natural history
Abstract

Arenig strata in the Napadogan area of the Miramichi Highlands of west-central New Brunswick are similar to those of the Lunksoos anticlinorial area of eastern Maine. Strata from both areas were deposited in a volcanic back-arc setting upon Cambrian-Tremadoc, deep-water, turbiditic quartzose strata on the northwest-facing Gander margin of Gondwana. Tremadoc southeastward obduction of the Penobscot Arc, formed in the Iapetus Ocean to the northwest of the margin, was followed by local uplift, rift faulting, erosion, and finally by local deposition of late Arenig gravel within the early stages of a subsiding back-arc basin that was related to a younger, northwest-facing, early Arenig-Llanvirn Popelogan Arc lying to the northwest. These strata became overlain by late Arenig marine felsic tuff, sandy and silty tuff and mudstone, coarse textured and many hundreds of metres thick in the Lunksoos area but much finer and only a few metres thick farther from the volcanic centres, in the Napadogan area. During Llanvirn, the strata became covered with deep-water, commonly manganiferous, ferruginous shalechert in a basin shielded from currents carrying coarse detritus. Arenig strata of the Napadogan area probably developed to the southeast of the main rift-volcanism zone that perhaps extended between the Lunksoos and northeastern Miramichi Highlands during the Arenig. Brachiopods of the Celtic paleogeographic assemblage colonized newly formed shelves flanking islands along the zone. Shell beds developed upon fresh layers of ash in a nutrient-rich environment between episodes of volcanism. These Celtic brachiopods developed in cool waters of high southern latitudes off Gondwana, different from those on the Laurentian margin in warm waters of low southern latitudes., RESUME Les strates de l'Arenig dans le secteur de Napadogan du massif de Miramichi, dans le centre-ouest du Nouveau-Brunswick, sont semblables a celles du secteur anticlinorial de Lunksoos dans l'Est [...]

Published
2002

8. Insufficient Nitric Oxide Bio-Availability (INOBA): An hypothesis to explain adverse effects of RBC transfusion

Author

Roback, John D., Neuman, Robert B., Quyyumi, Arshed, and Sutliff, Roy

Subjects
Erythrocytes, Blood Preservation, Humans, Erythrocyte Transfusion, Nitric Oxide, Article
Abstract

While transfusion of red blood cells (RBCs) is effective at preventing morbidity and mortality in anemic patients, studies have indicated that some RBC components have functional defects ("RBC storage lesions") that may actually cause adverse events when transfused. For example, in some studies patients transfused with RBCs stored more than 14 days have had statistically worse outcomes than those receiving "fresher" RBC units. Recipient-specific factors may also contribute to the occurrence of these adverse events. Unfortunately, these events have been difficult to investigate because up to now they have existed primarily as "statistical occurrences" of increased morbidity and mortality in large data sets. There are currently no clinical or laboratory methods to detect or study them in individual transfusion recipients. We propose a unifying hypothesis, centered on insufficient nitric oxide bioavailability (INOBA), to explain the increased morbidity and mortality observed in some patients after RBC transfusion. In this model, variables associated with RBC units (storage time; 2,3-diphosphoglycerate acid concentration) and transfusion recipients (endothelial dysfunction) collectively lead to changes in nitric oxide (NO) levels in vascular beds. Under certain circumstances, these variables are "aligned" such that NO concentrations are markedly reduced, leading to vasoconstriction, decreased local blood flow, and insufficient O(2) delivery to end organs. Under these circumstances, the likelihood of morbidity and mortality escalates. If the key tenets of the INOBA hypothesis are confirmed, it may lead to improved transfusion methods including altered RBC storage and/or processing conditions, novel transfusion recipient screening methods, and improved RBC-recipient matching.

Published
2011

13. P17

Author

Neuman, Robert B., primary, Polhemus, David, additional, Karatela, Sulaiman, additional, Sher, Salman, additional, Newman, James, additional, Quyyumi, Arshed, additional, Roback, John, additional, and Lefer, David J., additional

Published
2013
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15. Nitric Oxide Contributes to Vasomotor Tone in Hypertensive African Americans Treated With Nebivolol and Metoprolol.

Author

Neuman, Robert B., Hayek, Salim S., Poole, Joseph C., Rahman, Ayaz, Menon, Vivek, Kavtaradze, Nino, Polhemus, David, Veledar, Emir, Lefer, David J., and Quyyumi, Arshed A.

Subjects
*BLACK people, *BLOOD circulation, *VASODILATION, *COMPARATIVE studies, *CROSSOVER trials, *FOREARM, *HYPERTENSION, *RESEARCH methodology, *MEDICAL cooperation, *METOPROLOL, *MUSCLE hypotonia, *NITRIC oxide, *PLETHYSMOGRAPHY, *RESEARCH, *RESEARCH funding, *SYMPATHETIC nervous system, *EVALUATION research, *BLIND experiment
Abstract

Endothelial dysfunction is more prevalent in African Americans (AAs) compared with whites. The authors hypothesized that nebivolol, a selective β1 -antagonist that stimulates nitric oxide (NO), will improve endothelial function in AAs with hypertension when compared with metoprolol. In a double-blind, randomized, crossover study, 19 AA hypertensive patients were randomized to a 12-week treatment period with either nebivolol 10 mg or metoprolol succinate 100 mg daily. Forearm blood flow (FBF) was measured using plethysmography at rest and after intra-arterial infusion of acetylcholine and sodium nitroprusside to estimate endothelium-dependent and independent vasodilation, respectively. Physiologic vasodilation was assessed during hand-grip exercise. Measurements were repeated after NO blockade with L-N(G) -monomethylarginine (L-NMMA) and after inhibition of endothelium-derived hyperpolarizing factor (EDHF) with tetraethylammonium chloride (TEA). NO blockade with L-NMMA produced a trend toward greater vasoconstriction during nebivolol compared with metoprolol treatment (21% vs 12% reduction in FBF, P=.06, respectively). This difference was more significant after combined administration of L-NMMA and TEA (P<.001). Similarly, there was a contribution of NO to exercise-induced vasodilation during nebivolol but not during metoprolol treatment. There were significantly greater contributions of NO and EDHF to resting vasodilator tone and of NO to exercise-induced vasodilation with nebivolol compared with metoprolol in AAs with hypertension. [ABSTRACT FROM AUTHOR]

Published
2016
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21. Famatinorthis cf.F. turneri Levy and Nullo, 1973 (brachiopoda, orthida) from the Shin Brook...

Author

Neuman, Robert B.

Subjects
*BRACHIOPODA
Abstract

Presents information on Famatinorthis cf.F. turneri Levy and Nullo, 1973, an abundant component of a poorly preserved brachiopod assemblage in volcaniclastic rocks in Arenig-age Shin Brook Formation in northeastern Maine. What the brachiopod assemblage of the Shin Brooke Formation is classed as; Information on Famatinorthis turneri sensu stricto; How Famatinorthis turneri occurs.

Published
1997
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23. CORRESPONDENCE.

Author

Blackstone, Sidney, Barton, Allen H., Neuman, Robert B., and Arbogast, Fred E.

Subjects
LETTERS to the editor, AMERICAN politicians, UNITED States political parties, POLITICAL candidates, POLITICAL campaigns
Abstract

Presents letters to the editor. Comments on the threat to U.S. politician Helen Gahagan Douglas from a Third Party candidate; Discussion of an article on the Bogota uprising; Comments on an article on U.S. politician Harold Stassen.

Published
1948

41. Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection.

Author

Thaweethai T, Jolley SE, Karlson EW, Levitan EB, Levy B, McComsey GA, McCorkell L, Nadkarni GN, Parthasarathy S, Singh U, Walker TA, Selvaggi CA, Shinnick DJ, Schulte CCM, Atchley-Challenner R, Alba GA, Alicic R, Altman N, Anglin K, Argueta U, Ashktorab H, Baslet G, Bassett IV, Bateman L, Bedi B, Bhattacharyya S, Bind MA, Blomkalns AL, Bonilla H, Brim H, Bush PA, Castro M, Chan J, Charney AW, Chen P, Chibnik LB, Chu HY, Clifton RG, Costantine MM, Cribbs SK, Davila Nieves SI, Deeks SG, Duven A, Emery IF, Erdmann N, Erlandson KM, Ernst KC, Farah-Abraham R, Farner CE, Feuerriegel EM, Fleurimont J, Fonseca V, Franko N, Gainer V, Gander JC, Gardner EM, Geng LN, Gibson KS, Go M, Goldman JD, Grebe H, Greenway FL, Habli M, Hafner J, Han JE, Hanson KA, Heath J, Hernandez C, Hess R, Hodder SL, Hoffman MK, Hoover SE, Huang B, Hughes BL, Jagannathan P, John J, Jordan MR, Katz SD, Kaufman ES, Kelly JD, Kelly SW, Kemp MM, Kirwan JP, Klein JD, Knox KS, Krishnan JA, Kumar A, Laiyemo AO, Lambert AA, Lanca M, Lee-Iannotti JK, Logarbo BP, Longo MT, Luciano CA, Lutrick K, Maley JH, Mallett G, Marathe JG, Marconi V, Marshall GD, Martin CF, Matusov Y, Mehari A, Mendez-Figueroa H, Mermelstein R, Metz TD, Morse R, Mosier J, Mouchati C, Mullington J, Murphy SN, Neuman RB, Nikolich JZ, Ofotokun I, Ojemakinde E, Palatnik A, Palomares K, Parimon T, Parry S, Patterson JE, Patterson TF, Patzer RE, Peluso MJ, Pemu P, Pettker CM, Plunkett BA, Pogreba-Brown K, Poppas A, Quigley JG, Reddy U, Reece R, Reeder H, Reeves WB, Reiman EM, Rischard F, Rosand J, Rouse DJ, Ruff A, Saade G, Sandoval GJ, Santana JL, Schlater SM, Sciurba FC, Shepherd F, Sherif ZA, Simhan H, Singer NG, Skupski DW, Sowles A, Sparks JA, Sukhera FI, Taylor BS, Teunis L, Thomas RJ, Thorp JM, Thuluvath P, Ticotsky A, Tita AT, Tuttle KR, Urdaneta AE, Valdivieso D, VanWagoner TM, Vasey A, Verduzco-Gutierrez M, Wallace ZS, Ward HD, Warren DE, Weiner SJ, Welch S, Whiteheart SW, Wiley Z, Wisnivesky JP, Yee LM, Zisis S, Horwitz LI, and Foulkes AS

Subjects
Female, Adult, Humans, Middle Aged, Male, Prospective Studies, Post-Acute COVID-19 Syndrome, Cohort Studies, Disease Progression, Fatigue, SARS-CoV-2, COVID-19 complications
Abstract

Importance: SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. Characterizing PASC requires analysis of prospectively and uniformly collected data from diverse uninfected and infected individuals., Objective: To develop a definition of PASC using self-reported symptoms and describe PASC frequencies across cohorts, vaccination status, and number of infections., Design, Setting, and Participants: Prospective observational cohort study of adults with and without SARS-CoV-2 infection at 85 enrolling sites (hospitals, health centers, community organizations) located in 33 states plus Washington, DC, and Puerto Rico. Participants who were enrolled in the RECOVER adult cohort before April 10, 2023, completed a symptom survey 6 months or more after acute symptom onset or test date. Selection included population-based, volunteer, and convenience sampling., Exposure: SARS-CoV-2 infection., Main Outcomes and Measures: PASC and 44 participant-reported symptoms (with severity thresholds)., Results: A total of 9764 participants (89% SARS-CoV-2 infected; 71% female; 16% Hispanic/Latino; 15% non-Hispanic Black; median age, 47 years [IQR, 35-60]) met selection criteria. Adjusted odds ratios were 1.5 or greater (infected vs uninfected participants) for 37 symptoms. Symptoms contributing to PASC score included postexertional malaise, fatigue, brain fog, dizziness, gastrointestinal symptoms, palpitations, changes in sexual desire or capacity, loss of or change in smell or taste, thirst, chronic cough, chest pain, and abnormal movements. Among 2231 participants first infected on or after December 1, 2021, and enrolled within 30 days of infection, 224 (10% [95% CI, 8.8%-11%]) were PASC positive at 6 months., Conclusions and Relevance: A definition of PASC was developed based on symptoms in a prospective cohort study. As a first step to providing a framework for other investigations, iterative refinement that further incorporates other clinical features is needed to support actionable definitions of PASC.

Published
2023
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