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410 results on '"Neugebauer, W."'

3. Genomweite Untersuchung identifiziert den hepatischen Cholesterol Transporter ABCG8 als Suszeptibilitäts-Faktor für das humane Gallensteinleiden

Author

Schafmayer, Clemens, Buch, S., Egberts, J., Krawczak, M., Fölsch, U. R., Völzke, H., Nürnberg, P., Vogel, I., Dittrich, H., Belz, J., Quäschling, R., Shekarriz, H., Mendel, V., Neugebauer, W., Kallinowski, F., Klima, J., Sailer, M., Schafmayer, A., Schreiber, S., Kremer, B., Fändrich, F., Hampe, J., Tepel, J., Bruch, H. P., editor, Büchler, M. W., editor, Buhr, H. J., editor, Hohenberger, W., editor, Klar, E., editor, Post, S., editor, Schilling, M., editor, Schumpelick, V., editor, Siewert, J. R., editor, Thiede, A., editor, Becker, H., editor, Bittner, R., editor, Függer, R., editor, Köckerling, F., editor, Saeger, H. D., editor, Zornig, C., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Senninger, N., editor, Allgayer, H., editor, Bruns, C. J., editor, Celik, I., editor, Fries, H., editor, Kalthoff, H., editor, Schackert, H. K., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Holzheimer, R. G., editor, Holzmann, B., editor, Schade, U. F., editor, Vollmar, B., editor, Heidecke, C. D., editor, Menger, M. D., editor, Neugebauer, E., editor, Spiegel, H. U., editor, Germann, G., editor, Haas, N., editor, Langer, S., editor, Machens, H. G., editor, Stark, G. B., editor, Steinau, H. U., editor, Haverich, A., editor, Heberer, M., editor, Fitze, G., editor, Roth, H., editor, von Schweinitz, D., editor, Waag, K. L., editor, Altendorf-Hofmann, A., editor, Lehnert, T., editor, Lorenz, W., editor, Ohmann, C., editor, Bechstein, W. O., editor, Broelsch, C., editor, Hopt, U., editor, Klempnauer, J., editor, Fändrich, F., editor, Markus, B., editor, Minor, T., editor, Neuhaus, P., editor, Wonigeit, K., editor, Dralle, H., editor, Goretzki, P. E., editor, Rothmund, M., editor, Bühren, V., editor, Josten, C., editor, Muhr, G., editor, Nast-Kolb, D., editor, Stürmer, K. M., editor, Trentz, O., editor, Brunkwall, J., editor, Sandmann, W., editor, Schmitz-Rixen, T., editor, Storck, M., editor, Branscheid, D., editor, Dienemann, H., editor, Hirner, A., editor, Passlick, B., editor, Toomes, H., editor, Beyersdorf, F., editor, Hetzer, R., editor, Schäfers, H. J., editor, Steinsträßer, L., editor, Vogt, P., editor, Arbogast, R., editor, and Bauer, H., editor

Published
2008
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6. Genomweite Untersuchung identifiziert den hepatischen Cholesterol Transporter ABCG8 als Suszeptibilitäts-Faktor für das humane Gallensteinleiden

Author

Schafmayer, Clemens, primary, Buch, S., additional, Egberts, J., additional, Krawczak, M., additional, Fölsch, U. R., additional, Völzke, H., additional, Nürnberg, P., additional, Vogel, I., additional, Dittrich, H., additional, Belz, J., additional, Quäschling, R., additional, Shekarriz, H., additional, Mendel, V., additional, Neugebauer, W., additional, Kallinowski, F., additional, Klima, J., additional, Sailer, M., additional, Schafmayer, A., additional, Schreiber, S., additional, Kremer, B., additional, Fändrich, F., additional, Hampe, J., additional, and Tepel, J., additional

Published
2008
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9. Solution structure and adenylyl cyclase stimulating activities of C-terminal truncated human parathyroid hormone analogues

Author

Neugebauer, W., Barbier, J.-R., Sung, W.L., Whitfield, J.F., and Willick, G.E.

Subjects
Adenylate cyclase -- Analysis, Parathyroid hormone -- Models, Circular dichroism -- Usage, Biological sciences, Chemistry
Abstract

Study on C-terminal truncated human parathyroid hormone (hPTH) by CD data on hPTH-(16-34)-NH2 and C-terminal deletion mutants of hPTH-(1-34)-NH2 and the carboxyl-terminal mutant, hPTH-(1-30)-OH2, showed equal stabilization of alpha-helix in the presence of palmitoyloleoylphosphatidylserine (POPS) vesicles. This supports the facts that an amphiphilic alpha-helix over residues 21-28 is the conformation for receptor binding of hPTH for stimulation of adenyl cyclase activities.

Published
1995

21. Putting out halon: at Kozloduy 5 and 6, it was necessary to replace halon fire extinguishers for object protection of electrical cabinets

Author

Neugebauer, W. and Gechev, O.

Subjects
Fire extinguishing agents -- Usage, Fire extinguishing agents -- Design and construction, Nuclear industry -- Safety and security measures, Fire extinguishers -- Usage, Fire extinguishers -- Design and construction, Cabinets -- Safety and security measures, Business, Business, international, Petroleum, energy and mining industries
Abstract

At Kozloduy 5 and 6 the existing halon extinguishing systems are designed as object protection systems for electrical cabinet rows. Each of these rows is protected by a small dedicated [...]

Published
2004

34. Toxikologische Untersuchungen

Author

Elsdon, G. D., Stubbs, J. R., Bartholomew, E. J., Raby, E. C., Inouye, T., Chatterji, D. N., Ganguly, K. R., Faruqi, M. Z., van Itallie, L., Plum, K., Garratt, D. C., Gager, R., Mayer, R. M., Berg, R., Laguna, St., Schönlebe, H., Timm, F., Servantie, L., Goldman, F. H., Neugebauer, W., Jungmichel, G., Schückle, H., Pilati, L., and Burkhardt, W.

Published
1939
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37. Agonist-dependent modulation of arterial endothelinA receptor function

Author

Compeer, M. G., Meens, M. J. P. M. T., Hackeng, T. M., Neugebauer, W. A., Hoeltke, C., De Mey, J. G. R., Promovendi CD, Biochemie, Pharmacology and Personalised Medicine, Farmacologie en Toxicologie, and RS: CARIM School for Cardiovascular Diseases

Subjects
allosteric modulation, endothelin-1, ETA receptors, agonist-dependence
Abstract

BACKGROUND AND PURPOSE Endothelin-1 (ET-1) causes long-lasting vasoconstrictions. These can be prevented by ETA receptor antagonists but are only poorly reversed by these drugs. We tested the hypothesis that endothelin ETA receptors are susceptible to allosteric modulation by endogenous agonists and exogenous ligands. EXPERIMENTAL APPROACH Rat isolated mesenteric resistance arteries were pretreated with capsaicin and studied in wire myographs, in the presence of L-NAME and indomethacin to concentrate on arterial smooth muscle responses. KEY RESULTS Endothelins caused contractions with equal maximum but differing potency (ET-1 = ET-2 > ET-3). ET-1115 neither mimicked nor antagonized these effects in the absence and presence of ET1621. 4AlaET-1 (ETB agonist) and BQ788 (ETB antagonist) were without effects. BQ123 (peptide ETA antagonist) reduced the sensitivity and relaxed the contractile responses to endothelins. Both effects depended on the agonist (pKB: ET-3 = ET-1 > ET-2; % relaxation: ET-3 = ET-2 > ET-1). Also, with PD156707 (non-peptide ETA antagonist) agonist-dependence and a discrepancy between preventive and inhibitory effects were observed. The latter was even more marked with bulky analogues of BQ123 and PD156707. CONCLUSIONS AND IMPLICATIONS These findings indicate allosteric modulation of arterial smooth muscle ETA receptor function by endogenous agonists and by exogenous endothelin receptor antagonists. This may have consequences for the diagnosis and pharmacotherapy of diseases involving endothelins.

Published
2012

46. Pertinence of tests used for conformity assessments of fire resistance of nuclear power plant components - opinion of several institutions in Europe

Author

UCL - FSA/MAPR - Département des sciences des matériaux et des procédés, Bruynooghe, C., Rowekamp, M., Hostikka, S., Richard, J., Maillet, E., Neugebauer, W., Zdenek, T., UCL - FSA/MAPR - Département des sciences des matériaux et des procédés, Bruynooghe, C., Rowekamp, M., Hostikka, S., Richard, J., Maillet, E., Neugebauer, W., and Zdenek, T.

Abstract

Fire resistance of structures, systems and components (SSC) is widely identified as a fundamental issue for fire risk assessment at nuclear power plants (NPP). It is currently supported by several national or international ambitious experimental programs. Fire risk assessment at NPPs is performed under a series of hypothesis, e.g. the fire load. A problem will arise if tests used for conformity assessment do not appropriately represent the hypothesis selected during the fire risk analysis. In this case, SSCs may possibly be not meeting the expectations related to their fire resistance capacity supposed by the fire risk analysis. Ways of tackling this issue involve a regulatory approach and adapted requirements for components. While the widespread regulatory approach consists in seeking enveloping scenarios and conservative assumptions, a better knowledge of SSCs behaviour under for NPPs typical situations may be also desirable. The Institute for Energy of the European Commission's Joint Research Centre (JRC) at Pet-ten (NL) launched a questionnaire with the aim of gathering opinions of regulatory bodies and their technical support organisations and manufacturers in Europe on this topic. Major goal was to estimate the relevance of the issue according to the perception of the specialists. The present paper collects the answers given by seven entities (AREVA, GRS, iBMB, IRSN, SJUB SUEZ-TRACTEBEL, and VTT) and makes suggestions for addressing the issues identified by the participants..

Published
2010

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