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4. Benchmark problems for transcranial ultrasound simulation: Intercomparison of compressional wave models

Author

Aubry, Jean-Francois, Bates, Oscar, Boehm, Christian, Pauly, Kim Butts, Christensen, Douglas, Cueto, Carlos, Gelat, Pierre, Guasch, Lluis, Jaros, Jiri, Jing, Yun, Jones, Rebecca, Li, Ningrui, Marty, Patrick, Montanaro, Hazael, Neufeld, Esra, Pichardo, Samuel, Pinton, Gianmarco, Pulkkinen, Aki, Stanziola, Antonio, Thielscher, Axel, Treeby, Bradley, and Wout, Elwin van 't

Subjects
Physics - Computational Physics
Abstract

Computational models of acoustic wave propagation are frequently used in transcranial ultrasound therapy, for example, to calculate the intracranial pressure field or to calculate phase delays to correct for skull distortions. To allow intercomparison between the different modeling tools and techniques used by the community, an international working group was convened to formulate a set of numerical benchmarks. Here, these benchmarks are presented, along with intercomparison results. Nine different benchmarks of increasing geometric complexity are defined. These include a single-layer planar bone immersed in water, a multi-layer bone, and a whole skull. Two transducer configurations are considered (a focused bowl and a plane piston), giving a total of 18 permutations of the benchmarks. Eleven different modeling tools are used to compute the benchmark results. The models span a wide range of numerical techniques, including the finite-difference time-domain method, angular-spectrum method, pseudospectral method, boundary-element method, and spectral-element method. Good agreement is found between the models, particularly for the position, size, and magnitude of the acoustic focus within the skull. When comparing results for each model with every other model in a cross comparison, the median values for each benchmark for the difference in focal pressure and position are less than 10\% and 1 mm, respectively. The benchmark definitions, model results, and intercomparison codes are freely available to facilitate further comparisons., Comment: 18 pages, 7 figures

Published
2022
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5. Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning

Author

Wessel, Maximilian J., Beanato, Elena, Popa, Traian, Windel, Fabienne, Vassiliadis, Pierre, Menoud, Pauline, Beliaeva, Valeriia, Violante, Ines R., Abderrahmane, Hedjoudje, Dzialecka, Patrycja, Park, Chang-Hyun, Maceira-Elvira, Pablo, Morishita, Takuya, Cassara, Antonino M., Steiner, Melanie, Grossman, Nir, Neufeld, Esra, and Hummel, Friedhelm C.

Published
2023
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9. The SPARC DRC: Building a Resource for the Autonomic Nervous System Community

Author

Osanlouy, Mahyar, Bandrowski, Anita, de Bono, Bernard, Brooks, David, Cassarà, Antonino M, Christie, Richard, Ebrahimi, Nazanin, Gillespie, Tom, Grethe, Jeffrey S, Guercio, Leonardo A, Heal, Maci, Lin, Mabelle, Kuster, Niels, Martone, Maryann E, Neufeld, Esra, Nickerson, David P, Soltani, Elias G, Tappan, Susan, Wagenaar, Joost B, Zhuang, Katie, and Hunter, Peter J

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Neurosciences, Bioengineering, SPARC, autonomic nervous system, FAIR, data curation, data annotation, neural mapping, knowledge management, computational life sciences, Physiology, Medical Physiology, Psychology, Biochemistry and cell biology, Medical physiology
Abstract

The Data and Resource Center (DRC) of the NIH-funded SPARC program is developing databases, connectivity maps, and simulation tools for the mammalian autonomic nervous system. The experimental data and mathematical models supplied to the DRC by the SPARC consortium are curated, annotated and semantically linked via a single knowledgebase. A data portal has been developed that allows discovery of data and models both via semantic search and via an interface that includes Google Map-like 2D flatmaps for displaying connectivity, and 3D anatomical organ scaffolds that provide a common coordinate framework for cross-species comparisons. We discuss examples that illustrate the data pipeline, which includes data upload, curation, segmentation (for image data), registration against the flatmaps and scaffolds, and finally display via the web portal, including the link to freely available online computational facilities that will enable neuromodulation hypotheses to be investigated by the autonomic neuroscience community and device manufacturers.

Published
2021

12. Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Author

Rowald, Andreas, Komi, Salif, Demesmaeker, Robin, Baaklini, Edeny, Hernandez-Charpak, Sergio Daniel, Paoles, Edoardo, Montanaro, Hazael, Cassara, Antonino, Becce, Fabio, Lloyd, Bryn, Newton, Taylor, Ravier, Jimmy, Kinany, Nawal, D’Ercole, Marina, Paley, Aurélie, Hankov, Nicolas, Varescon, Camille, McCracken, Laura, Vat, Molywan, Caban, Miroslav, Watrin, Anne, Jacquet, Charlotte, Bole-Feysot, Léa, Harte, Cathal, Lorach, Henri, Galvez, Andrea, Tschopp, Manon, Herrmann, Natacha, Wacker, Moïra, Geernaert, Lionel, Fodor, Isabelle, Radevich, Valentin, Van Den Keybus, Katrien, Eberle, Grégoire, Pralong, Etienne, Roulet, Maxime, Ledoux, Jean-Baptiste, Fornari, Eleonora, Mandija, Stefano, Mattera, Loan, Martuzzi, Roberto, Nazarian, Bruno, Benkler, Stefan, Callegari, Simone, Greiner, Nathan, Fuhrer, Benjamin, Froeling, Martijn, Buse, Nik, Denison, Tim, Buschman, Rik, Wende, Christian, Ganty, Damien, Bakker, Jurriaan, Delattre, Vincent, Lambert, Hendrik, Minassian, Karen, van den Berg, Cornelis A. T., Kavounoudias, Anne, Micera, Silvestro, Van De Ville, Dimitri, Barraud, Quentin, Kurt, Erkan, Kuster, Niels, Neufeld, Esra, Capogrosso, Marco, Asboth, Leonie, Wagner, Fabien B., Bloch, Jocelyne, and Courtine, Grégoire

Published
2022
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17. Non-Invasive Deep-Brain Stimulation Using Pulsed Temporally Interfering Electric Fields for Epilepsy

Author

Acerbo, Emma, primary, Botzanowski, Boris, additional, Dellavale, Damian, additional, Stern, Matthew A., additional, Cole, Eric R., additional, Gutekunst, Claire-Anne, additional, Gantt, Miller L., additional, Steiner, Melanie, additional, Missey, Florian, additional, Cassara, Antonino, additional, Neufeld, Esra, additional, Berglund, Ken, additional, Jirsa, Viktor, additional, Gross, Robert E., additional, Drane, Daniel L., additional, Glowacki, Eric Daniel, additional, Pakhomov, Andrei G., additional, and Williamson, Adam, additional

Published
2024
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21. Effects of hippocampal noninvasive theta-burst stimulation on consolidation of associative memory in healthy older adults

Author

Popa, Traian, primary, Beanato, Elena, additional, Wessel, Maximilian Jonas, additional, Menoud, Pauline, additional, Windel, Fabienne, additional, Vassiliadis, Pierre, additional, Violante, Ines R., additional, Alania, Katevan, additional, Dzialecka, Patrycja, additional, Grossman, Nir, additional, Neufeld, Esra, additional, and Hummel, Friedhelm C., additional

Published
2023
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22. Simulation techniques in hyperthermia treatment planning

Author

Paulides, Margarethus M, Stauffer, Paul R, Neufeld, Esra, Maccarini, Paolo F, Kyriakou, Adamos, Canters, Richard AM, Diederich, Chris J, Bakker, Jurriaan F, and Van Rhoon, Gerard C

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Computer Simulation, Humans, Hyperthermia, Induced, Models, Biological, Neoplasms, Electromagnetic, pennes bioheat equation, SAR, thermal dose, ultrasound, Clinical Sciences, Oncology & Carcinogenesis, Clinical sciences
Abstract

Abstract Clinical trials have shown that hyperthermia (HT), i.e. an increase of tissue temperature to 39-44 °C, significantly enhance radiotherapy and chemotherapy effectiveness [1]. Driven by the developments in computational techniques and computing power, personalised hyperthermia treatment planning (HTP) has matured and has become a powerful tool for optimising treatment quality. Electromagnetic, ultrasound, and thermal simulations using realistic clinical set-ups are now being performed to achieve patient-specific treatment optimisation. In addition, extensive studies aimed to properly implement novel HT tools and techniques, and to assess the quality of HT, are becoming more common. In this paper, we review the simulation tools and techniques developed for clinical hyperthermia, and evaluate their current status on the path from 'model' to 'clinic'. In addition, we illustrate the major techniques employed for validation and optimisation. HTP has become an essential tool for improvement, control, and assessment of HT treatment quality. As such, it plays a pivotal role in the quest to establish HT as an efficacious addition to multi-modality treatment of cancer.

Published
2013

23. Controlling focality and intensity of non-invasive deep brain stimulation using multipolar temporal interference in non-human primates and rodents

Author

Botzanowski, Boris, primary, ACERBO, Emma, additional, lehmann, sebastian, additional, Kearsley, Sarah L, additional, Steiner, Melanie, additional, Neufeld, Esra, additional, MISSEY, Florian, additional, Muller, Lyle, additional, Jirsa, Viktor, additional, Corneil, Brian D, additional, and Williamson, Adam, additional

Published
2023
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25. From Image-Based Modeling to the Modeling of Imaging with the Virtual Population

Author

Neufeld, Esra, Lloyd, Bryn, Kuster, Niels, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Tsaftaris, Sotirios A., editor, Gooya, Ali, editor, Frangi, Alejandro F., editor, and Prince, Jerry L., editor

Published
2016
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26. Covering Population Variability: Morphing of Computation Anatomical Models

Author

Lloyd, Bryn, Cherubini, Emilio, Farcito, Silvia, Neufeld, Esra, Baumgartner, Christian, Kuster, Niels, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Tsaftaris, Sotirios A., editor, Gooya, Ali, editor, Frangi, Alejandro F., editor, and Prince, Jerry L., editor

Published
2016
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28. Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves

Author

Gupta, Isha, Cassará, Antonino M., Tarotin, Ilya, Donega, Matteo, Miranda, Jason A., Sokal, David M., Ouchouche, Sebastien, Dopson, Wesley, Matteucci, Paul, Neufeld, Esra, Schiefer, Matthew A., Rowles, Alison, McGill, Paul, Perkins, Justin, Dolezalova, Nikola, Saeb-Parsy, Kourosh, Kuster, Niels, Yazicioglu, Refet Firat, Witherington, Jason, and Chew, Daniel J.

Published
2020
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29. Targeted neurotechnology restores walking in humans with spinal cord injury

Author

Wagner, Fabien B., Mignardot, Jean-Baptiste, Le Goff-Mignardot, Camille G., Demesmaeker, Robin, Komi, Salif, Capogrosso, Marco, Rowald, Andreas, Seáñez, Ismael, Caban, Miroslav, Pirondini, Elvira, Vat, Molywan, McCracken, Laura A., Heimgartner, Roman, Fodor, Isabelle, Watrin, Anne, Seguin, Perrine, Paoles, Edoardo, Van Den Keybus, Katrien, Eberle, Grégoire, Schurch, Brigitte, Pralong, Etienne, Becce, Fabio, Prior, John, Buse, Nicholas, Buschman, Rik, Neufeld, Esra, Kuster, Niels, Carda, Stefano, von Zitzewitz, Joachim, Delattre, Vincent, Denison, Tim, Lambert, Hendrik, Minassian, Karen, Bloch, Jocelyne, and Courtine, Grégoire

Published
2018
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32. Obstructive Sleep Apnea Improves with Non-invasive Hypoglossal Nerve Stimulation using Temporal Interference

Author

Missey, Florian, primary, Ejneby, Malin Silverå, additional, Ngom, Ibrahima, additional, Donahue, Mary J., additional, Trajlinek, Jan, additional, Acerbo, Emma, additional, Botzanowski, Boris, additional, Cassarà, Antonino M., additional, Neufeld, Esra, additional, Glowacki, Eric D., additional, Shangold, Lee, additional, Hanes, William M., additional, and Williamson, Adam, additional

Published
2023
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34. Theory for a non-invasive diagnostic biomarker for craniospinal diseases

Author

Highfield Research Group, Brain, Cancer, Circulatory Health, Regenerative Medicine and Stem Cells, Karimi, Fariba, Neufeld, Esra, Fallahi, Arya, Boraschi, Andrea, Zwanenburg, Jaco J M, Spiegelberg, Andreas, Kurtcuoglu, Vartan, Kuster, Niels, Highfield Research Group, Brain, Cancer, Circulatory Health, Regenerative Medicine and Stem Cells, Karimi, Fariba, Neufeld, Esra, Fallahi, Arya, Boraschi, Andrea, Zwanenburg, Jaco J M, Spiegelberg, Andreas, Kurtcuoglu, Vartan, and Kuster, Niels

Published
2023

35. The effect of body position change on noninvasively acquired intracranial pulse waves

Author

Boraschi, Andrea; https://orcid.org/0000-0002-2908-5234, Spiegelberg, Andreas; https://orcid.org/0000-0002-3812-3191, Karimi, Fariba, Graf, Kevin, Fallahi, Arya; https://orcid.org/0000-0002-5142-8934, Neufeld, Esra; https://orcid.org/0000-0001-5528-6147, Kuster, Niels; https://orcid.org/0000-0002-5827-3728, Kurtcuoglu, Vartan; https://orcid.org/0000-0003-2665-0995, Boraschi, Andrea; https://orcid.org/0000-0002-2908-5234, Spiegelberg, Andreas; https://orcid.org/0000-0002-3812-3191, Karimi, Fariba, Graf, Kevin, Fallahi, Arya; https://orcid.org/0000-0002-5142-8934, Neufeld, Esra; https://orcid.org/0000-0001-5528-6147, Kuster, Niels; https://orcid.org/0000-0002-5827-3728, and Kurtcuoglu, Vartan; https://orcid.org/0000-0003-2665-0995

Abstract

Objective. Craniospinal compliance (CC) is an important metric for the characterization of space-occupying neurological pathologies. CC is obtained using invasive procedures that carry risks for the patients. Therefore, noninvasive methods for acquiring surrogates of CC have been proposed, most recently based on changes in the head’s dielectric properties during the cardiac cycle. Here, we have tested whether changes in body position, which are known to influence CC, are reflected in a capacitively acquired signal (hereinafter referred to as W) originating from dynamic changes of the head’s dielectric properties. Approach. eighteen young healthy volunteers were included in the study. After 10 min in supine position, subjects were tilted head-up (HUT), back to 0° (horizontal, control), and then head-down (HDT). Metrics related to cardiovascular action were extracted from W, including AMP, the peak-to-valley amplitude of the cardiac modulation of W. Computational electromagnetic simulations were performed to probe the association between intracranial volume change and W. Main results. AMP decreased during HUT (0°: 2869 ± 597 arbitrary units (au); +75°: 2307 ± 490 au, P = 0.002) and increased during HDT (−30°: 4403 ± 1428 au, P < 0.0001). The same behavior was predicted by the electromagnetic model. Significance. tilting affects the distribution of CC between cranial and spinal compartments. Cardiovascular action induces compliance-dependent oscillatory changes in the intracranial fluid composition, which causes corresponding variations in the head’s dielectric properties. These manifest as increasing AMP with decreasing intracranial compliance, which suggests that W may contain information related to CC, and that it might be possible to derive CC surrogates therefrom.

Published
2023

36. Noninvasive Monitoring of Intracranial Pulse Waves

Author

Spiegelberg, Andreas; https://orcid.org/0000-0002-3812-3191, Boraschi, Andrea; https://orcid.org/0000-0002-2908-5234, Karimi, Fariba, Capstick, Myles, Fallahi, Arya, Neufeld, Esra; https://orcid.org/0000-0001-5528-6147, Kuster, Niels; https://orcid.org/0000-0002-5827-3728, Kurtcuoglu, Vartan; https://orcid.org/0000-0003-2665-0995, Spiegelberg, Andreas; https://orcid.org/0000-0002-3812-3191, Boraschi, Andrea; https://orcid.org/0000-0002-2908-5234, Karimi, Fariba, Capstick, Myles, Fallahi, Arya, Neufeld, Esra; https://orcid.org/0000-0001-5528-6147, Kuster, Niels; https://orcid.org/0000-0002-5827-3728, and Kurtcuoglu, Vartan; https://orcid.org/0000-0003-2665-0995

Abstract

Objective: The clinical management of several neurological disorders benefits from the assessment of intracranial pressure and craniospinal compliance. However, the associated procedures are invasive in nature. Here, we aimed to assess whether naturally occurring periodic changes in the dielectric properties of the head could serve as the basis for deriving surrogates of craniospinal compliance noninvasively. Methods: We designed a device and electrodes for noninvasive measurement of periodic changes of the dielectric properties of the human head. We characterized the properties of the device-electrode-head system by measurements on healthy volunteers, by computational modeling, and by electromechanical modeling. We then performed hyperventilation testing to assess whether the measured signal is of intracranial origin. Results: Signals obtained with the device on volunteers showed characteristic cardiac and respiratory modulations. Signal oscillations can be attributed primarily to changes in resistive properties of the head during cardiac and respiratory cycles. Reduction of end-tidal CO2, through hyperventilation, resulted in a decrease in the signal amplitude associated with cardiovascular action. Conclusion: Given the higher CO2 reactivity of intracranial vessels compared to extracranial ones, the results of hyperventilation testing suggest that the acquired signal is, in part, of intracranial origin. Significance: If confirmed in larger cohorts, our observations suggest that noninvasive capacitive acquisition of changes in the dielectric properties of the head could be used to derive surrogates of craniospinal compliance.

Published
2023

40. Noninvasive Monitoring of Intracranial Pulse Waves

Author

Spiegelberg, Andreas, primary, Boraschi, Andrea, additional, Karimi, Fariba, additional, Capstick, Myles, additional, Fallahi, Arya, additional, Neufeld, Esra, additional, Kuster, Niels, additional, and Kurtcuoglu, Vartan, additional

Published
2023
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41. Non-invasive temporal interference electrical stimulation of the human hippocampus

Author

Violante, Ines, primary, Alania, Ketevan, additional, Cassarà, Antonino, additional, Neufeld, Esra, additional, Acerbo, Emma, additional, Williamson, Adam, additional, Kurtin, Danielle, additional, Rhodes, Edward, additional, Hampshire, Adam, additional, Kuster, Niels, additional, Boyden, Edward, additional, Pascual-Leone, Alvaro, additional, and Grossman, Nir, additional

Published
2023
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46. LTP-like noninvasive striatal brain stimulation enhances striatal activity and motor skill learning in humans

Author

Wessel, Maximilian J., primary, Beanato, Elena, additional, Popa, Traian, additional, Windel, Fabienne, additional, Vassiliadis, Pierre, additional, Menoud, Pauline, additional, Beliaeva, Valeriia, additional, Violante, Ines R., additional, Abderrahmane, Hedjoudje, additional, Dzialecka, Patrycja, additional, Park, Chang-Hyun, additional, Maceira-Elvira, Pablo, additional, Morishita, Takuya, additional, Cassara, Antonino, additional, Steiner, Melanie, additional, Grossman, Nir, additional, Neufeld, Esra, additional, and Hummel, Friedhelm C., additional

Published
2022
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