1. Does the Combined Effect of Resistance Training with EPO and Iron Sulfate Improve Iron Metabolism in Older Individuals with End-Stage Renal Disease?
- Author
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Corrêa HL, Alfaro-Magallanes VM, Moura SRG, Neves RVP, Deus LA, Honorato FS, Silva VL, Raab ATO, Maia BCH, Padula IA, Gusmão Alves LS, Machado RA, Reis AL, Prestes J, Ferreira CES, Neto LSDS, Tavares FS, Andrade RV, and Rosa TDS
- Subjects
- Aged, Ferritins blood, Ferrous Compounds therapeutic use, Hemoglobins analysis, Hepcidins blood, Humans, Inflammation therapy, Iron blood, Middle Aged, Erythropoietin therapeutic use, Kidney Failure, Chronic therapy, Resistance Training
- Abstract
We sought to investigate the effects of resistance training (RT) combined with erythropoietin (EPO) and iron sulfate on the hemoglobin, hepcidin, ferritin, iron status, and inflammatory profile in older individuals with end-stage renal disease (ESRD). ESRD patients ( n : 157; age: 66.8 ± 3.6; body mass: 73 ± 15; body mass index: 27 ± 3), were assigned to control (CTL; n : 76) and exercise groups (RT; n : 81). The CTL group was divided according to the iron treatment received: without iron treatment (CTL-none; n = 19), treated only with iron sulfate or EPO (CTL-EPO or IRON; n = 19), and treated with both iron sulfate and EPO (CTL-EPO + IRON; n = 76). The RT group followed the same pattern: (RT-none; n = 20), (RT-EPO or IRON; n = 18), and (RT-EPO + IRON; n = 86). RT consisted of 24 weeks/3 days per week at moderate intensity of full-body resistance exercises prior to the hemodialysis section. The RT group, regardless of the iron treatment, improved iron metabolism in older individuals with ESRD. These results provide some clues on the effects of RT and its combination with EPO and iron sulfate in this population, highlighting RT as an important coadjutant in ESRD-iron deficiency.
- Published
- 2021
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