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6. Importance of interdisciplinarity in modern oncology: results of a national intergroup survey of the Young Oncologists United (YOU)

Author

Mäurer, Matthias, Staudacher, Jonas, Meyer, Robert, Mäurer, Irina, Lazaridis, Lazaros, Müther, Michael, Huber, Tobias, Sommer, Nils P., Fleischmann, Daniel F., Käsmann, Lukas, Ziegler, Sonia, Kropf-Sanchen, Cornelia, Wikert, Julia, Pietzner, Klaus, Holzgreve, Adrien, Nestler, Tim, Siech, Carolin, Sturm, Max-Johann, Sulzer, Sabrina, Heinrich, Kathrin, and Stahler, Arndt

Published
2023
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8. Priapismus

Author

Nestler, Tim, Schmelz, Hans, Hakenberg, Oliver W., Section editor, Michel, Maurice Stephan, editor, W. Thüroff, Joachim, editor, Janetschek, Günter, editor, and Wirth, Manfred P., editor

Published
2023
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13. Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life

Author

Selle, Jaco, Dinger, Katharina, Jentgen, Vanessa, Zanetti, Daniela, Will, Johannes, Georgomanolis, Theodoros, Vohlen, Christina, Wilke, Rebecca, Kojonazarov, Baktybek, Klymenko, Oleksiy, Mohr, Jasmine, v. Koningsbruggen-Rietschel, Silke, Rhodes, Christopher J., Ulrich, Anna, Hirani, Dharmesh, Nestler, Tim, Odenthal, Margarete, Mahabir, Esther, Nayakanti, Sreenath, Dabral, Swati, Wunderlich, Thomas, Priest, James, Seeger, Werner, Dötsch, Jörg, Pullamsetti, Soni S., and Alejandre Alcazar, Miguel A.

Published
2022
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14. Trophoblast cell surface antigen‐2: a promising new biomarker and potential therapeutic target in penile squamous cell carcinoma.

Author

Weiten, Richard, Storz, Enno, Kessler, Carolina, Sperber, Laurenz, Spohn, Hanna Elisa, Pfister, David, Nestler, Tim, Tolkach, Yuri, Linden, Friederike, Wirtz, Ralph, von Brandenstein, Melanie, Krausewitz, Philipp, and Heidenreich, Axel

Subjects
IMMUNOSTAINING, SQUAMOUS cell carcinoma, LYMPHATIC metastasis, GENE expression, BLOOD proteins
Abstract

Objective: To evaluate the potential utility of antibody‐drug conjugates targeting trophoblast cell surface antigen‐2 (TROP‐2) in patients with primary penile squamous cell carcinoma (PSCC), patients with recurrence (REC cohort), and patient‐matched distant metastases (MET cohort), and to assess the potential use of TROP‐2 as a predictive non‐invasive biomarker in PSCC. Methods: A cohort comprising a PRIM (n = 37), REC (n = 5) and MET subcohort (n = 7), with MET including lymph node and lung metastases, was analysed using quantitative real‐time PCR, ELISA and immunohistochemical staining with evaluation of H‐score. Results: TROP‐2 mRNA and serum protein levels were significantly increased in primary and recurrent PSCC compared to cancer‐free controls (both P < 0.001). Immunohistochemical analysis revealed that most of the PRIM cohort (n = 34/37, median H‐score 260, interquartile range [IQR] 210–300), as well as all patients in the REC (median [IQR] H‐score 200 [165–290]) and MET cohorts (median [IQR] H‐score 280 [260–300]) exhibited moderate to strong membranous TROP‐2 expression. Additionally, The H‐score (membranous TROP‐2 expression) was positively correlated with TROP‐2 mRNA (ρ = 0.69, P < 0.0001, R2 = 0.70) and protein levels (ρ = 0.86, P < 0.0001, R2 = 0.59), indicating its potential as a non‐invasive biomarker in PSCC. Conclusion: In summary, our results support further studies on TROP‐2 as a diagnostic and therapeutic target in primary, recurrent and metastatic PSCC. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Radiological Assessment of Different Retroperitoneal Lymph Node Measurements in Stage 1 Testicular Cancer Patients: Impact on Clinical Stage and Treatment.

Author

Strauch, Angelina, Nestler, Kai, Schoch, Justine, Kubitscheck, Laura, Waldeck, Stephan, Schmelz, Hans, and Nestler, Tim

Subjects
GERM cell tumors, LYMPHATIC metastasis, LYMPH nodes, TESTICULAR cancer, OVERALL survival
Abstract

Background: In staging for testicular germ cell tumor (GCT), current guidelines lack consensus regarding the measurement of retroperitoneal lymph node metastasis, concerning the recommended plane and dimension. This exploratory study aimed to assess its impact on clinical stage (cS) and therapy. Methods: We retrospectively examined 154 cSI (retroperitoneal lymph nodes < 10 mm in axial short-axis diameter (SAD)) GCT patients, without adjuvant therapy and a follow-up ≥ 24 months. Retroperitoneal lymph nodes were measured in staging images in different dimensions (SAD and long-axis diameter (LAD)) and planes (axial, sagittal and coronal). Results: Overall survival was 100%, with 82% free of recurrence after a median follow-up of 83 months. All patients were classified as cSI, based on axial SAD (RECIST 1.1). However, significantly more patients would have been classified as cSIIA (0% vs. 38% vs. 52%) or even cSIIB (0% vs. 1% vs. 25%) according to axial LAD (SWENOTECA, German S3 guideline) or maximum LAD in any plane (EAU, ESMO, AJCC and onkopedia) (p < 0.001). Overtreatment was predicted in 0%, 31% and 61% of patients based on axial SAD, axial LAD and maximum LAD, while undertreatment was estimated at 18%, 10% and 2%, respectively, (p < 0.001). Conclusions: These findings indicate considerable variability in cS based on current lymph node staging recommendations, suggesting that axial SAD (RECIST 1.1) could be the most appropriate parameter for standardized guideline recommendations. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Bildgebung

Author

Nestler, Tim, Knoll, Thomas, editor, Miernik, Arkadiusz, editor, and Alken, Peter, Foreword by

Published
2021
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17. Erstmalige interdisziplinäre DKK-Programmplanung durch Zusammenschluss onkologischer Nachwuchsgruppen

Author

Mäurer, Matthias A., Huber, Tobias, Sommer, Nils P., Mäurer, Irina, Lazaridis, Lazaros, Bodensohn, Raphael, Ziegler, Sonia, Fleischmann, Daniel F., Käsmann, Lukas, Staudacher, Jonas, Kropf-Sanchen, Cornelia, Scherg, Alexandra, Wikert, Julia, Pietzner, Klaus, Oing, Christoph, Beyer, Georg, Hollenbach, Marcus, Nestler, Tim, Siech, Carolin, Meyer, Robert, Heinrich, Kathrin, and Stahler, Arndt

Published
2022
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19. Serum Levels of MicroRNA-371a-3p for Predicting the Histology of Postchemotherapy Residual Masses of Germ Cell Tumours

Author

Dieckmann, Klaus-Peter, primary, Grobelny, Francesca, additional, Soave, Armin, additional, Che, Yue, additional, Nestler, Tim, additional, Matthies, Cord, additional, Heinzelbecker, Julia, additional, Winter, Alexander, additional, Heidenreich, Axel, additional, Niemzok, Tabea, additional, Dumlupinar, Cansu, additional, Angerer, Markus, additional, Wülfing, Christian, additional, Paffenholz, Pia, additional, and Belge, Gazanfer, additional

Published
2024
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20. MP61-08 TROP-2—A PROMISING NEW THERAPEUTIC TARGET IN PENILE SQUAMOUS CELL CARCINOMA

Author

Weiten, Richard, primary, Kessler, Carolina, additional, Meisl, Christina, additional, Spohn, Hanna Elisa, additional, Storz, Enno, additional, Pfister, David, additional, Nestler, Tim, additional, Tolkach, Yuri, additional, Linden, Friederike, additional, Wirtz, Ralph, additional, von Brandenstein, Melanie, additional, Krausewitz, Philipp, additional, and Heidenreich, Axel, additional

Published
2024
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22. The prognostic significance of lactate dehydrogenase levels in seminoma patients with advanced disease: an analysis by the Global Germ Cell Tumor Collaborative Group (G3)

Author

Seidel, Christoph, Daugaard, Gedske, Nestler, Tim, Tryakin, Alexey, Fedyanin, Mikhail, Fankhauser, Christian Daniel, Hermanns, Thomas, Aparicio, Jorge, Heinzelbecker, Julia, Paffenholz, Pia, Heidenreich, Axel, De Giorgi, Ugo, Cathomas, Richard, Lorch, Anja, Fingerhut, Anna, Gayer, Fabian, Bremmer, Felix, Giannatempo, Patrizia, Necchi, Andrea, Raggi, Daniele, Aurilio, Gaetano, Casadei, Chiara, Hentrich, Marcus, Tran, Ben, Dieckmann, Klaus-Peter, Brito, Margarido, Ruf, Christian, Mazzocca, Alessandro, Vincenzi, Bruno, Stahl, Olof, Bokemeyer, Carsten, and Oing, Christoph

Published
2021
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25. Molecular and histopathological characterization of seminoma patients with highly elevated human chorionic gonadotropin levels in the serum.

Author

Seidel, Christoph, Paulsen, Finn-Ole, Nestler, Tim, Cathomas, Richard, Hentrich, Marcus, Paffenholz, Pia, Bokemeyer, Carsten, Heidenreich, Axel, Nettersheim, Daniel, and Bremmer, Felix

Abstract

Approximately 30% of seminoma (SEM) patients present with moderately elevated human chorionic gonadotropin (hCG) levels at first diagnosis. In case of high hCG serum levels, the presence of a non-SEM component, i.e. choriocarcinoma (CC), may be assumed. To characterize cases described as pure seminoma with high serum hCG levels, tissue samples and DNA were analyzed. Patient files from an international registry were screened for patients with SEM and extraordinarily high hCG serum levels. IHC and qRT-PCR analysis was performed for markers of SEM, embryonal carcinoma (EC) and CC/trophoblast cells. The cell lines TCam-2 (SEM), 2102EP, NCCIT, NT2/D1 (EC) and JAR, JEG3 and BeWo (CC) were included for comparison. Of 1031 SEM patients screened, 39 patients (3.7%) showed hCG serum levels > 1000 U/l. Of these, tumor material for IHC and RNA for qRT-PCR was available from n = 7 patients and n = 3 patients, respectively. Median pre-orchiectomy serum hCG level was 5356 U/l (range: 1224–40909 U/L). Histopathologically, all investigated samples were classified as SEM with syncytiotrophoblast sub-populations. SEM cells were SALL4+ / OCT3/4+ / D2-40+, while syncytiotrophoblast cells were hCG+ / GATA3+ / p63+ and SOX2−/CDX2−. qRT-PCR analysis detected trophoblast stem cell markers CDX2, EOMES and TFAP2C as well as the trophectoderm-specifier TEAD4, but not GATA3. Additionally, SOX17 and PRAME, but not SOX2, were detected, confirming the pure SEM-like gene expression signature of the analyzed samples. In conclusion, excessively increased hCG serum levels can appear in patients with pure SEM. To explain detectable hCG serum levels, it is important to diagnose the subtype of a SEM with syncytiotrophoblasts. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Supplementary Table S4 from Detection of Recurrence through microRNA-371a-3p Serum Levels in a Follow-up of Stage I Testicular Germ Cell Tumors in the DRKS-00019223 Study

Author

Belge, Gazanfer, primary, Dumlupinar, Cansu, primary, Nestler, Tim, primary, Klemke, Markus, primary, Törzsök, Peter, primary, Trenti, Emanuela, primary, Pichler, Renate, primary, Loidl, Wolfgang, primary, Che, Yue, primary, Hiester, Andreas, primary, Matthies, Cord, primary, Pichler, Martin, primary, Paffenholz, Pia, primary, Kluth, Luis, primary, Wenzel, Mike, primary, Sommer, Jörg, primary, Heinzelbecker, Julia, primary, Schriefer, Philipp, primary, Winter, Alexander, primary, Zengerling, Friedemann, primary, Kramer, Mario Wolfgang, primary, Lengert, Marie, primary, Frey, Jana, primary, Heidenreich, Axel, primary, Wülfing, Christian, primary, Radtke, Arlo, primary, and Dieckmann, Klaus-Peter, primary

Published
2024
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28. Supplementary Figure S1 from Detection of Recurrence through microRNA-371a-3p Serum Levels in a Follow-up of Stage I Testicular Germ Cell Tumors in the DRKS-00019223 Study

Author

Belge, Gazanfer, primary, Dumlupinar, Cansu, primary, Nestler, Tim, primary, Klemke, Markus, primary, Törzsök, Peter, primary, Trenti, Emanuela, primary, Pichler, Renate, primary, Loidl, Wolfgang, primary, Che, Yue, primary, Hiester, Andreas, primary, Matthies, Cord, primary, Pichler, Martin, primary, Paffenholz, Pia, primary, Kluth, Luis, primary, Wenzel, Mike, primary, Sommer, Jörg, primary, Heinzelbecker, Julia, primary, Schriefer, Philipp, primary, Winter, Alexander, primary, Zengerling, Friedemann, primary, Kramer, Mario Wolfgang, primary, Lengert, Marie, primary, Frey, Jana, primary, Heidenreich, Axel, primary, Wülfing, Christian, primary, Radtke, Arlo, primary, and Dieckmann, Klaus-Peter, primary

Published
2024
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29. Data from Detection of Recurrence through microRNA-371a-3p Serum Levels in a Follow-up of Stage I Testicular Germ Cell Tumors in the DRKS-00019223 Study

Author

Belge, Gazanfer, primary, Dumlupinar, Cansu, primary, Nestler, Tim, primary, Klemke, Markus, primary, Törzsök, Peter, primary, Trenti, Emanuela, primary, Pichler, Renate, primary, Loidl, Wolfgang, primary, Che, Yue, primary, Hiester, Andreas, primary, Matthies, Cord, primary, Pichler, Martin, primary, Paffenholz, Pia, primary, Kluth, Luis, primary, Wenzel, Mike, primary, Sommer, Jörg, primary, Heinzelbecker, Julia, primary, Schriefer, Philipp, primary, Winter, Alexander, primary, Zengerling, Friedemann, primary, Kramer, Mario Wolfgang, primary, Lengert, Marie, primary, Frey, Jana, primary, Heidenreich, Axel, primary, Wülfing, Christian, primary, Radtke, Arlo, primary, and Dieckmann, Klaus-Peter, primary

Published
2024
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35. Detection of recurrence through microRNA-371a-3p serum levels in a follow-up of stage I testicular germ cell tumors in the DRKS-00019223 study

Author

Belge, Gazanfer, primary, Dumlupinar, Cansu, additional, Nestler, Tim, additional, Klemke, Markus, additional, Törzsök, Peter, additional, Trenti, Emanuela, additional, Pichler, Renate, additional, Loidl, Wolfgang, additional, Che, Yue, additional, Hiester, Andreas, additional, Matthies, Cord, additional, Pichler, Martin, additional, Paffenholz, Pia, additional, Kluth, Luis, additional, Wenzel, Mike, additional, Sommer, Jörg, additional, Heinzelbecker, Julia, additional, Schriefer, Philipp, additional, Winter, Alexander, additional, Zengerling, Friedemann, additional, Kramer, Mario Wolfgang., additional, Lengert, Marie, additional, Frey, Jana, additional, Heidenreich, Axel, additional, Wülfing, Christian, additional, Radtke, Arlo, additional, and Dieckmann, Klaus-Peter, additional

Published
2023
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42. Priapismus

Author

Nestler, Tim, Schmelz, Hans U., Michel, Maurice Stephan, editor, Thüroff, Joachim W., editor, Janetschek, Günther, editor, and Wirth, Manfred, editor

Published
2016
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46. Real world evidence from a retrospective multi-center analysis on first-line therapy for metastatic renal cell carcinoma with non-clear cell and/or sarcomatoid histologies.

Author

Paffenholz, Pia, Zschaebitz, Stefanie, Casuscelli, Jozefina, Rinderknecht, Emily, Mattigk, Angelika, Gür, Melis, Ivanyi, Philipp, Hilser, Thomas, Darr, Christopher, Mandal, Subhajit, Schlack, Katrin, Seidl, Daniel, Handke, Analena, Klee, Melanie, Nestler, Tim, Rehlinghaus, Marc, Hijazi, Sameh, Heidenreich, Axel, Grünwald, Viktor, and Schostak, Martin

Published
2024
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47. Treatment options and outcome of patients with metastatic renal cell carcinoma with brain or bone metastases: Real world evidence from a German retrospective multi-center analysis.

Author

Paffenholz, Pia, Ivanyi, Philipp, Casuscelli, Jozefina, Stelmach, Ramona, Guer, Melis, Schlack, Katrin, Darr, Christopher, Rinderknecht, Emily, Hilser, Thomas, Flegar, Luka, Klee, Melanie, Seidl, Daniel, Handke, Analena, Nestler, Tim, Mattigk, Angelika, Augustin, Marinela, Hijazi, Sameh, Rehlinghaus, Marc, Heidenreich, Axel, and Gruenwald, Viktor

Published
2024
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