1. Use of U.S. Blood Donors for National Serosurveillance of SARS-CoV-2 Antibodies: Basis for an Expanded National Donor Serosurveillance Program
- Author
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Stone, Mars, Di Germanio, Clara, Wright, David J, Sulaeman, Hasan, Dave, Honey, Fink, Rebecca V, Notari, Edward P, Green, Valerie, Strauss, Donna, Kessler, Debbie, Destree, Mark, Saa, Paula, Williamson, Phillip C, Simmons, Graham, Stramer, Susan L, Opsomer, Jean, Jones, Jefferson M, Kleinman, Steven, Busch, Michael P, Cassetti, C, Gerber, S, Patton, M, Havers, F, Basavaraju, S, Williams, AE, Anderson, S, Haynes, J, McCain, L, Hui, A, Samuels, C, Tanner, H, Kaidarova, Z, B, MP, Norris, PJ, S, M, Mathew, SM, Stramer, S, Kessler, D, Konkle, BA, Custer, B, Ness, PM, Kleinman, SH, Josephson, CD, Glynn, SA, and Malkin, K
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Lung ,Prevention ,Pneumonia ,Pneumonia & Influenza ,Biodefense ,Cancer ,Vaccine Related ,Infectious Diseases ,Emerging Infectious Diseases ,Good Health and Well Being ,Antibodies ,Viral ,Blood Donors ,COVID-19 ,Child ,Cross-Sectional Studies ,Humans ,SARS-CoV-2 ,Seroepidemiologic Studies ,COVID-19 srological testing ,seroprevalence ,NHLBI Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Clinical sciences - Abstract
BackgroundThe Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P) Epidemiology, Surveillance and Preparedness of the Novel SARS-CoV-2 Epidemic (RESPONSE) seroprevalence study conducted monthly cross-sectional testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in blood donors in 6 US metropolitan regions to estimate the extent of SARS-CoV-2 infections over time.MethodsDuring March-August 2020, approximately ≥1000 serum specimens were collected monthly from each region and tested for SARS-CoV-2 antibodies using a well-validated algorithm. Regional seroprevalence estimates were weighted based on demographic differences compared with the general population. Seroprevalence was compared with reported coronavirus disease 2019 (COVID-19) case rates over time.ResultsFor all regions, seroprevalence was
- Published
- 2022