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4. Incidence of deep vein thrombosis among non-ICU patients hospitalized for COVID-19 despite pharmacological thromboprophylaxis

Author

Santoliquido, Angelo, Porfidia, Angelo, Nesci, Domenico Arturo, De Matteis, Giuseppe, Marrone, Giuseppe, Porceddu, Enrica, Camma, Giulia, Giarretta, Igor, Fantoni, M., Landi, Francesco, Gasbarrini, Antonio, Pola, Roberto, D'Alfonso, Maria Elena, Lo Monaco, Maria Rita, Santoliquido A. (ORCID:0000-0003-1539-4017), Porfidia A., Nesci A. (ORCID:0000-0001-9466-1755), De Matteis G., Marrone G., Porceddu E., Camma G., Giarretta I. (ORCID:0000-0001-5380-0843), Landi F. (ORCID:0000-0002-3472-1389), Gasbarrini A. (ORCID:0000-0002-7278-4823), Pola R. (ORCID:0000-0001-5224-2931), D'Alfonso M. E., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Santoliquido, Angelo, Porfidia, Angelo, Nesci, Domenico Arturo, De Matteis, Giuseppe, Marrone, Giuseppe, Porceddu, Enrica, Camma, Giulia, Giarretta, Igor, Fantoni, M., Landi, Francesco, Gasbarrini, Antonio, Pola, Roberto, D'Alfonso, Maria Elena, Lo Monaco, Maria Rita, Santoliquido A. (ORCID:0000-0003-1539-4017), Porfidia A., Nesci A. (ORCID:0000-0001-9466-1755), De Matteis G., Marrone G., Porceddu E., Camma G., Giarretta I. (ORCID:0000-0001-5380-0843), Landi F. (ORCID:0000-0002-3472-1389), Gasbarrini A. (ORCID:0000-0002-7278-4823), Pola R. (ORCID:0000-0001-5224-2931), D'Alfonso M. E., and Lo Monaco M. R. (ORCID:0000-0002-1457-7981)

Abstract

Background: A remarkably high incidence of venous thromboembolism (VTE) has been reported among critically ill patients with COVID-19 assisted in the intensive care unit (ICU). However, VTE burden among non-ICU patients hospitalized for COVID-19 that receive guideline-recommended thromboprophylaxis is unknown. Objectives: To determine the incidence of VTE among non-ICU patients hospitalized for COVID-19 that receive pharmacological thromboprophylaxis. Methods: We performed a systematic screening for the diagnosis of deep vein thrombosis (DVT) by lower limb vein compression ultrasonography (CUS) in consecutive non-ICU patients hospitalized for COVID-19, independent of the presence of signs or symptoms of DVT. All patients were receiving pharmacological thromboprophylaxis with either enoxaparin or fondaparinux. Results: The population that we screened consisted of 84 consecutive patients, with a mean age of 67.6 ± 13.5 years and a mean Padua Prediction Score of 5.1 ± 1.6. Seventy-two patients (85.7%) had respiratory insufficiency, required oxygen supplementation, and had reduced mobility or were bedridden. In this cohort, we found 10 cases of DVT, with an incidence of 11.9% (95% confidence interval [CI] 4.98-18.82). Of these, 2 were proximal DVT (incidence rate 2.4%, 95% CI −0.87-5.67) and 8 were distal DVT (incidence rate 9.5%, 95% CI 3.23-5.77). Significant differences between subjects with and without DVT were D-dimer > 3000 µg/L (P <.05), current or previous cancer (P <.05), and need of high flow nasal oxygen therapy and/or non-invasive ventilation (P <.01). Conclusions: DVT may occur among non-ICU patients hospitalized for COVID-19, despite guideline-recommended thromboprophylaxis.

Published
2020

5. Liver involvement is not associated with mortality: results from a large cohort of SARS-CoV-2-positive patients

Author

Ponziani, Francesca Romana, Del Zompo, F., Nesci, Domenico Arturo, Santopaolo, F., Ianiro, Gianluca, Pompili, Maurizio, Gasbarrini, Antonio, Ponziani F. R. (ORCID:0000-0002-5924-6238), Nesci A. (ORCID:0000-0001-9466-1755), Ianiro G. (ORCID:0000-0002-8318-0515), Pompili M. (ORCID:0000-0001-6699-7980), Gasbarrini A. (ORCID:0000-0002-7278-4823), Ponziani, Francesca Romana, Del Zompo, F., Nesci, Domenico Arturo, Santopaolo, F., Ianiro, Gianluca, Pompili, Maurizio, Gasbarrini, Antonio, Ponziani F. R. (ORCID:0000-0002-5924-6238), Nesci A. (ORCID:0000-0001-9466-1755), Ianiro G. (ORCID:0000-0002-8318-0515), Pompili M. (ORCID:0000-0001-6699-7980), and Gasbarrini A. (ORCID:0000-0002-7278-4823)

Abstract

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is frequently associated with liver test abnormalities. Aims: To describe the evolution of liver involvement during SARS-CoV-2 infection and its effect on clinical course and mortality. Methods: Data of 515 SARS-CoV-2-positive patients were collected at baseline and during follow-up, last evaluation or death. Stratification based on need for hospitalisation, severe disease and admission to intensive care unit (ICU) was performed. The association between liver test abnormalities (baseline and peak values) and ICU admission or death was also explored. Results: Liver test abnormalities were found in 161 (31.3%) patients. Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) were increased in 20.4%, 19% and 13.6% of patients, respectively. Baseline liver test abnormalities were associated with increased risk of ICU admission (OR 2.19 [95% CI 1.24-3.89], P = 0.007) but not with mortality (OR 0.84 [95% CI 0.49-1.41], P = 0.51). Alkaline phosphatase (ALP) peak values were correlated with risk of death (OR 1.007 [95% CI 1.002-1.01], P = 0.005) along with age, multiple comorbidities, acute respiratory distress syndrome, ICU admission and C-reactive protein. Alterations of liver tests worsened within 15 days of hospitalisation; however, in patients with the longest median follow-up, the prevalence of liver test alterations decreased over time, returning to around baseline levels. Conclusions: In SARS-CoV-2-positive patients without pre-existing severe chronic liver disease, baseline liver test abnormalities are associated with the risk of ICU admission and tend to normalise over time. The ALP peak value may be predictive of a worse prognosis.

Published
2020

6. Post-COVID-19 global health strategies: the need for an interdisciplinary approach

Author

Landi, Francesco, Gremese, Elisa, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Settanni, Carlo Romano, Benvenuto, Francesca, Bramato, Giulia, Carfi, A., Ciciarello, Francesca, Lomonaco, M. R., Martone, Anna Maria, Marzetti, Emanuele, Napolitano, C., Pagano, Francesco Cosimo, Rocchi, Sara, Rota, Elisabetta, Salerno, A., Tosato, Matteo, Tritto, Marcello, Calvani, Riccardo, Catalano, Lucio, Picca, A., Savera, Giulia, Tamburrini, Enrica, Borghetti, Alberto, Di Gianbenedetto, S., Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, Eleonora, Moschese, D., Ciccullo, A., Stella, L., Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Geltrude, Zocco, Maria Assunta, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Bizzarro, Alessandra, Lauria, Alessandra, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Cozzupoli, G. M., Culiersi, Carola, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, Fabrizio, Di Cintio, G., Longobardi, Ylenia, Tricarico, Laura, Santantonio, Mariaconsiglia, Buonsenso, Danilo, Valentini, Piero, Pata, Davide, Sinatti, Dario, De Rose, Cristina, Richeldi, Luca, Lombardi, F., Calabrese, Anna Chiara, Sani, Gabriele, Janiri, D., Giuseppin, Giulia, Molinaro, Marzia, Modica, Marco, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Paglionico, A., Petricca, L., Gigante, Laura, Natalello, Gerlando, Fedele, A. L., Lizzio, Marco Maria, Santoliquido, Angelo, Santoro, Luca, Nesci, Domenico Arturo, Popolla, Valentina, Landi F. (ORCID:0000-0002-3472-1389), Gremese E. (ORCID:0000-0002-2248-1058), Bernabei R. (ORCID:0000-0002-9197-004X), Fantoni M. (ORCID:0000-0001-6913-8460), Gasbarrini A. (ORCID:0000-0002-7278-4823), Settanni C. R., Benvenuto F., Bramato G., Ciciarello F., Martone A. M., Marzetti E. (ORCID:0000-0001-9567-6983), Pagano F., Rocchi S., Rota E., Tosato M., Tritto M., Calvani R. (ORCID:0000-0001-5472-2365), Catalano L., Savera G., Tamburrini E. (ORCID:0000-0003-4930-426X), Borghetti A., Murri R. (ORCID:0000-0003-4263-7854), Cingolani A. (ORCID:0000-0002-3793-2755), Ventura G. (ORCID:0000-0002-0304-7264), Taddei E., Addolorato G. (ORCID:0000-0002-1522-9946), Franceschi F. (ORCID:0000-0001-6266-445X), Mingrone G. (ORCID:0000-0003-2021-528X), Zocco M. A. (ORCID:0000-0002-0814-9542), Sanguinetti M. (ORCID:0000-0002-9780-7059), Cattani P. (ORCID:0000-0003-4678-4763), Marchetti S., Bizzarro A., Lauria A., Rizzo S. (ORCID:0000-0001-6302-063X), Savastano M. C. (ORCID:0000-0003-1397-4333), Gambini G., Culiersi C., Passali G. C. (ORCID:0000-0002-8176-0962), Paludetti G. (ORCID:0000-0003-2480-1243), Galli J. (ORCID:0000-0001-6353-6249), Crudo F., Longobardi Y., Tricarico L., Santantonio M., Buonsenso D., Valentini P. (ORCID:0000-0001-6095-9510), Pata D., Sinatti D., De Rose C., Richeldi L. (ORCID:0000-0001-8594-1448), Calabrese A., Sani G. (ORCID:0000-0002-9767-8752), Giuseppin G., Molinaro M., Modica M., Natale L. (ORCID:0000-0002-7949-5119), Larici A. R. (ORCID:0000-0002-1882-6244), Marano R. (ORCID:0000-0003-2710-2093), Gigante L., Natalello G., Lizzio M. M., Santoliquido A. (ORCID:0000-0003-1539-4017), Santoro L., Nesci A. (ORCID:0000-0001-9466-1755), Popolla V., Landi, Francesco, Gremese, Elisa, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Settanni, Carlo Romano, Benvenuto, Francesca, Bramato, Giulia, Carfi, A., Ciciarello, Francesca, Lomonaco, M. R., Martone, Anna Maria, Marzetti, Emanuele, Napolitano, C., Pagano, Francesco Cosimo, Rocchi, Sara, Rota, Elisabetta, Salerno, A., Tosato, Matteo, Tritto, Marcello, Calvani, Riccardo, Catalano, Lucio, Picca, A., Savera, Giulia, Tamburrini, Enrica, Borghetti, Alberto, Di Gianbenedetto, S., Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, Eleonora, Moschese, D., Ciccullo, A., Stella, L., Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Geltrude, Zocco, Maria Assunta, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Bizzarro, Alessandra, Lauria, Alessandra, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Cozzupoli, G. M., Culiersi, Carola, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, Fabrizio, Di Cintio, G., Longobardi, Ylenia, Tricarico, Laura, Santantonio, Mariaconsiglia, Buonsenso, Danilo, Valentini, Piero, Pata, Davide, Sinatti, Dario, De Rose, Cristina, Richeldi, Luca, Lombardi, F., Calabrese, Anna Chiara, Sani, Gabriele, Janiri, D., Giuseppin, Giulia, Molinaro, Marzia, Modica, Marco, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Paglionico, A., Petricca, L., Gigante, Laura, Natalello, Gerlando, Fedele, A. L., Lizzio, Marco Maria, Santoliquido, Angelo, Santoro, Luca, Nesci, Domenico Arturo, Popolla, Valentina, Landi F. (ORCID:0000-0002-3472-1389), Gremese E. (ORCID:0000-0002-2248-1058), Bernabei R. (ORCID:0000-0002-9197-004X), Fantoni M. (ORCID:0000-0001-6913-8460), Gasbarrini A. (ORCID:0000-0002-7278-4823), Settanni C. R., Benvenuto F., Bramato G., Ciciarello F., Martone A. M., Marzetti E. (ORCID:0000-0001-9567-6983), Pagano F., Rocchi S., Rota E., Tosato M., Tritto M., Calvani R. (ORCID:0000-0001-5472-2365), Catalano L., Savera G., Tamburrini E. (ORCID:0000-0003-4930-426X), Borghetti A., Murri R. (ORCID:0000-0003-4263-7854), Cingolani A. (ORCID:0000-0002-3793-2755), Ventura G. (ORCID:0000-0002-0304-7264), Taddei E., Addolorato G. (ORCID:0000-0002-1522-9946), Franceschi F. (ORCID:0000-0001-6266-445X), Mingrone G. (ORCID:0000-0003-2021-528X), Zocco M. A. (ORCID:0000-0002-0814-9542), Sanguinetti M. (ORCID:0000-0002-9780-7059), Cattani P. (ORCID:0000-0003-4678-4763), Marchetti S., Bizzarro A., Lauria A., Rizzo S. (ORCID:0000-0001-6302-063X), Savastano M. C. (ORCID:0000-0003-1397-4333), Gambini G., Culiersi C., Passali G. C. (ORCID:0000-0002-8176-0962), Paludetti G. (ORCID:0000-0003-2480-1243), Galli J. (ORCID:0000-0001-6353-6249), Crudo F., Longobardi Y., Tricarico L., Santantonio M., Buonsenso D., Valentini P. (ORCID:0000-0001-6095-9510), Pata D., Sinatti D., De Rose C., Richeldi L. (ORCID:0000-0001-8594-1448), Calabrese A., Sani G. (ORCID:0000-0002-9767-8752), Giuseppin G., Molinaro M., Modica M., Natale L. (ORCID:0000-0002-7949-5119), Larici A. R. (ORCID:0000-0002-1882-6244), Marano R. (ORCID:0000-0003-2710-2093), Gigante L., Natalello G., Lizzio M. M., Santoliquido A. (ORCID:0000-0003-1539-4017), Santoro L., Nesci A. (ORCID:0000-0001-9466-1755), and Popolla V.

Abstract

For survivors of severe COVID-19 disease, having defeated the virus is just the beginning of an uncharted recovery path. What follows after the acute phase of SARS-CoV-2 infection depends on the extension and severity of viral attacks in different cell types and organs. Despite the ridiculously large number of papers that have flooded scientific journals and preprint-hosting websites, a clear clinical picture of COVID-19 aftermath is vague at best. Without larger prospective observational studies that are only now being started, clinicians can retrieve information just from case reports and or small studies. This is the time to understand how COVID-19 goes forward and what consequences survivors may expect to experience. To this aim, a multidisciplinary post-acute care service involving several specialists has been established at the Fondazione Policlinico Universitario A. Gemelli IRCSS (Rome, Italy). Although COVID-19 is an infectious disease primarily affecting the lung, its multi-organ involvement requires an interdisciplinary approach encompassing virtually all branches of internal medicine and geriatrics. In particular, during the post-acute phase, the geriatrician may serve as the case manager of a multidisciplinary team. The aim of this article is to describe the importance of the interdisciplinary approach––coordinated by geriatrician––to cope the potential post-acute care needs of recovered COVID-19 patients.

Published
2020

7. Subclinical atherosclerosis and endothelial dysfunction in patients with polymyalgia rheumatica: a pilot study

Author

Santoro, L, Birra, D, Bosello, Silvia Laura, Nesci, Domenico Arturo, Di Giorgio, A, Peluso, Eugenio, Giupponi, B, Zaccone, V, Gasbarrini, Antonio, Zoli, Angelo, Santoliquido, Angelo, Bosello, S (ORCID:0000-0002-4837-447X), Nesci, A (ORCID:0000-0001-9466-1755), Peluso, G, Gasbarrini, A (ORCID:0000-0002-7278-4823), Zoli, A (ORCID:0000-0003-1597-058X), Santoliquido, A (ORCID:0000-0003-1539-4017), Santoro, L, Birra, D, Bosello, Silvia Laura, Nesci, Domenico Arturo, Di Giorgio, A, Peluso, Eugenio, Giupponi, B, Zaccone, V, Gasbarrini, Antonio, Zoli, Angelo, Santoliquido, Angelo, Bosello, S (ORCID:0000-0002-4837-447X), Nesci, A (ORCID:0000-0001-9466-1755), Peluso, G, Gasbarrini, A (ORCID:0000-0002-7278-4823), Zoli, A (ORCID:0000-0003-1597-058X), and Santoliquido, A (ORCID:0000-0003-1539-4017)

Abstract

N/A

Published
2020

8. Effects of a New Combination of Medical Food on Endothelial Function and Lipid Profile in Dyslipidemic Subjects: A Pilot Randomized Trial

Author

Landi, Francesco, Martone, A. M., Salini, S., Zazzara, B., Calvani, Riccardo, Marzetti, Emanuele, Nesci, Domenico Arturo, Di Giorgio, A., Giupponi, B., Santoro, L., Santoliquido, Angelo, Landi F. (ORCID:0000-0002-3472-1389), Calvani R. (ORCID:0000-0001-5472-2365), Marzetti E. (ORCID:0000-0001-9567-6983), Nesci A. (ORCID:0000-0001-9466-1755), Santoliquido A. (ORCID:0000-0003-1539-4017), Landi, Francesco, Martone, A. M., Salini, S., Zazzara, B., Calvani, Riccardo, Marzetti, Emanuele, Nesci, Domenico Arturo, Di Giorgio, A., Giupponi, B., Santoro, L., Santoliquido, Angelo, Landi F. (ORCID:0000-0002-3472-1389), Calvani R. (ORCID:0000-0001-5472-2365), Marzetti E. (ORCID:0000-0001-9567-6983), Nesci A. (ORCID:0000-0001-9466-1755), and Santoliquido A. (ORCID:0000-0003-1539-4017)

Abstract

Nutritional approaches to improve dyslipidemias have been recently developed, but evidences on different medical foods are often incomplete. The main aim of our study was to evaluate the effects on endothelial function, lipid profile, and glucose metabolism of two different combinations of nutraceuticals, first one containing Bergavit (200 mg Citrus bergamia), Omega-3 (400 mg), Crominex 3+ (10 mcg trivalent chromium), and red yeast rice (100 mg; 5 mg monacolin K) and second one containing red yeast rice (200 mg; 3 mg monacolin K), Berberine (500 mg), Astaxanthin (0.5 mg), folic acid (200 mcg), Coenzyme Q10 (2 mg), and Policosanol (10 mg). Fifty subjects affected by dyslipidemia not requiring statin treatment were enrolled in this randomized, blind, controlled trial and submitted to blood sampling for lipid and glucose profiles and instrumental evaluation of endothelial function before and after 6 weeks of treatment with nutraceuticals. Both nutraceutical combinations improved the lipid profile; the nutraceutical containing 5 mg of monacolin K, 200 mg of the extract Citrus bergamia, 400 mg of Omega-3, and 10 mcg of trivalent chromium entailed a significant improvement of endothelial function with enhanced cholesterol lowering effect. In conclusion, this study confirms the positive effect of functional food on lipid profile and endothelial function in absence of major undesirable effects.

Published
2019

9. Integrated rehabilitation after total laryngectomy: a pilot trial study

Author

Longobardi, Ylenia, Savoia, Vezio, Bussu, Francesco, Morra, Luciana, Mari, Giorgia, Nesci, Domenico Arturo, Parrilla, Claudio, D'Alatri, Lucia, Longobardi Y., Savoia V., Bussu F. (ORCID:0000-0001-6261-2772), Mari G., Nesci D. A. (ORCID:0000-0001-9466-1755), Parrilla C., D'Alatri L. (ORCID:0000-0003-3104-958X), Longobardi, Ylenia, Savoia, Vezio, Bussu, Francesco, Morra, Luciana, Mari, Giorgia, Nesci, Domenico Arturo, Parrilla, Claudio, D'Alatri, Lucia, Longobardi Y., Savoia V., Bussu F. (ORCID:0000-0001-6261-2772), Mari G., Nesci D. A. (ORCID:0000-0001-9466-1755), Parrilla C., and D'Alatri L. (ORCID:0000-0003-3104-958X)

Abstract

BackgroundAcquisition and acceptance of the alaryngeal voice, psychological state, and Quality of Life (QoL) of laryngectomized patients.MethodsThirty-two patients who underwent total laryngectomy were included in the study; 17 of them were treated by a psychologist and a speech therapist (experimental group); 15 performed only speech therapy (control group).ResultsThe experimental group showed a significant improvement in all parameters of the INFVo scale, in the score of the Environment subscale and in the total score of the I-SECEL (Self-Evaluation of Communication Experiences after Laryngeal Cancer); in the Depression, Obsession-Compulsion and Paranoia areas of the SCL-90-R (Symptom Check List-90-Revised); and in the Social area (REL) of the WHOQOL-B (World Health Organization Quality of Life Scale-Brief).ConclusionsAn integrated rehabilitative approach to laryngectomized patients improves emotional state and psychosocial aspects and promotes acceptance and use of the new voice and recovery of a better quality of life.

Published
2019

10. A novel ultrasound-based vascular calcification score (CALCS) to detect subclinical atherosclerosis

Author

Flore, Roberto Antonio, Zocco, Maria Assunta, Ainora, Maria Elena, Fonnesu, C., Nesci, Domenico Arturo, Gasbarrini, Antonio, Ponziani, Francesca Romana, Flore R. (ORCID:0000-0003-1659-1338), Zocco M. A. (ORCID:0000-0002-0814-9542), Ainora M. E., Nesci A. (ORCID:0000-0001-9466-1755), Gasbarrini A. (ORCID:0000-0002-7278-4823), Ponziani F. R. (ORCID:0000-0002-5924-6238), Flore, Roberto Antonio, Zocco, Maria Assunta, Ainora, Maria Elena, Fonnesu, C., Nesci, Domenico Arturo, Gasbarrini, Antonio, Ponziani, Francesca Romana, Flore R. (ORCID:0000-0003-1659-1338), Zocco M. A. (ORCID:0000-0002-0814-9542), Ainora M. E., Nesci A. (ORCID:0000-0001-9466-1755), Gasbarrini A. (ORCID:0000-0002-7278-4823), and Ponziani F. R. (ORCID:0000-0002-5924-6238)

Abstract

OBJECTIVE: To quantify non-coronary vascular calcifications (VC) in asymptomatic patients at low-intermediate cardiovascular risk by a new color Doppler ultrasound (DUS)-based score (the carotid, aortic, lower limbs calcium score, CALCs), and to correlate this score with classical parameters associated with cardiovascular risk [carotid intima media thickness (IMT), and arterial stiffness (AS)].PATIENTS AND METHODS: All consecutive asymptomatic patients who underwent a screening DUS of non-coronary circulation were evaluated and patients at low-intermediate cardiovascular risk were selected according to Framingham risk score (FRS).Among them, we enrolled 70 patients with US evidence of VC and 71 age, sex and FRS matched controls. The presence of VC was correlated with classical markers of cardiovascular risk, such as AS and intima-media thickness (IMT). AS, expressed as pulse wave velocity (PWV) and arterial distensibility, carotid IMT and CALCs were measured for both groups. AS and c-IMT were assessed by a new Radio-Frequency (RF) DUS-based method. CALCs was generated by our previously described B-mode DUS-based method according to number/size of VC in 11 non-coronary segments (range 0-33).RESULTS: Patients with VC presented higher AS and IMT values than controls (PWV 8.34 +/- 0.98 m/s vs. 6.74 +/- 0.68 m/s, p<0.0001; arterial distensibility 267 12 mm vs. 315 65 mm, p=0.001; IMT 687 132 mm vs. 572 91 mm, p<0.0001). Mean CALCs of patients with VC was 8.41 +/- 7.78. CALCs were significantly correlated with c-IMT (p<0.0001; r=0.3), PWV (p<0.0001; r=0.4) and arterial distensibility (p=0.002; r=-0.1).CONCLUSIONS: DUS-based CALCs is highly correlated with other validated markers of sub clinical atherosclerosis, such as c-IMT and AS. Our results demonstrated the ability of CALCs to identify individual predictive factors beyond the traditional risk factors by quantifying an interesting and novel step of the atherogenic pro cess. Future studies on larger series a

Published
2018

11. Exercise and Protein Intake: A Synergistic Approach against Sarcopenia

Author

Martone, Anna Maria, Marzetti, Emanuele, Calvani, Riccardo, Picca, A., Tosato, Matteo, Santoro, Luca, Di Giorgio, Angela, Nesci, Domenico Arturo, Sisto, A., Santoliquido, Angelo, Landi, Francesco, Martone A. M., Marzetti E. (ORCID:0000-0001-9567-6983), Calvani R. (ORCID:0000-0001-5472-2365), Tosato M., Santoro L., Di Giorgio A., Nesci A. (ORCID:0000-0001-9466-1755), Santoliquido A. (ORCID:0000-0003-1539-4017), Landi F. (ORCID:0000-0002-3472-1389), Martone, Anna Maria, Marzetti, Emanuele, Calvani, Riccardo, Picca, A., Tosato, Matteo, Santoro, Luca, Di Giorgio, Angela, Nesci, Domenico Arturo, Sisto, A., Santoliquido, Angelo, Landi, Francesco, Martone A. M., Marzetti E. (ORCID:0000-0001-9567-6983), Calvani R. (ORCID:0000-0001-5472-2365), Tosato M., Santoro L., Di Giorgio A., Nesci A. (ORCID:0000-0001-9466-1755), Santoliquido A. (ORCID:0000-0003-1539-4017), and Landi F. (ORCID:0000-0002-3472-1389)

Abstract

Sarcopenia, the age-dependent loss of muscle mass and function/strength, is increasingly recognized as a major risk factor for adverse outcomes in frail older people. As such, the skeletal muscle is a relevant target for interventions aimed at preventing or postponing the occurrence of negative health-related events in late life. The association among physical inactivity, insufficient intake of energy and protein, and poor muscle health in older adults suggests that physical exercise and targeted nutritional supplementation may offer substantial therapeutic gain against sarcopenia and its negative correlates. This view is supported by observational studies as well as by small-scale clinical trials. In this review, we summarize the available evidence on the beneficial effects of behavioral interventions on sarcopenia. We also briefly describe how the knowledge gathered so far has been used to design the "Sarcopenia and Physical fRailty IN older people: multicomponenT Treatment strategies" (SPRINTT) project. The randomized clinical trial conducted within SPRINTT will provide robust evidence on the effectiveness of exercise and nutrition at preventing negative outcomes associated with sarcopenia and physical frailty.

Published
2017

12. Multimedia Psychotherapy: brief report of a pilot study.

Author

Nesci DA, Chiarella SG, Corona E, Savoia V, Zampogna M, Nesci FA, Porcaro G, Mari G, Nappa MR, Palummieri A, Calabrese L, Raffone A, Averna S, Dunn LB, Almadori G, and Paludetti G

Subjects
Emotions, Grief, Humans, Pilot Projects, Psychotherapy, Multimedia, Psychotherapy, Brief
Abstract

Introduction: Multimedia Psychotherapy is a new form of brief psychotherapy based on narrative medicine and ethnopsychoanalytic theories, developed to help patients affected by prolonged grief disorder (ICD-11). It consists of eight sessions, during which an 'audio-video memory object' is produced by using pictures, video clips, and music chosen by the bereaved patient. The audio-video montage is focused on remembering the deceased relative and help the patient to move on. Considering initial positive results, we ran a first controlled pilot study comparing experimental and control group., Methods: We enrolled a sample of bereaved patients who were referred for prolonged grief disorder (ICD-11) by their general practitioners or psychiatrists. Patients were randomly assigned to the experimental group (n=18) or to the control group (n=18). Patients in the experimental group received psycho-pharmacological therapy and multimedia psychotherapy, while patients in the control group received psycho-pharmacological therapy and psycho-oncological support. All patients were assessed with Minnesota Multiphasic Personality Inventory-2 (MMPI-2) and Prolonged Grief-13 (PG-13) prior to beginning treatment (pre-treatment), and with PG-13 after six months from the end of the treatment (post-treatment)., Results: Patients in the experimental group (i.e., Multimedia Psychotherapy treatment) after six months performed better than patients in the control group in Criteria B, D, and E of PG-13 (i.e.: Separation Distress, Cognitive, Emotional, and Behavioral Symptoms, Functional Impairment)., Discussion: We will discuss our results, issues related to the screening of patients (due to possible contraindications of Multimedia Psychotherapy), and methodological limitations. Finally, we will discuss new future applications in other clinical situations., Conclusions: These findings suggest that multimedia psychotherapy may hold promise for the treatment of prolonged grief disorder (ICD-11).

Published
2021
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