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Neuroimaging in Parkinson's Disease and Related Disorders discusses the advances of molecular, structural and functional neuroimaging techniques associated with the etiology, pathophysiology, effects and complications of novel therapies in Parkinson's and related disorders. With new neuroimaging methodologies emerging over the past five years, this book provides a comprehensive overview of new technologies and research. Sections discuss the biomarker value of neuroimaging of the brain to understand disease progression in vivo in actual patients with Parkinson's disease and related disorders. Readers will be updated on in vivo pathology and pathophysiology in Parkinson's disease and in a number of related disorders. Also discussed is the association between clinical symptoms, clinical progression, and molecular, structural, and functional changes in the brain of patients with Parkinson's disease and related disorders. - Comprehensive overview of biomarker value of neuroimaging of the brain to understand disease progression in vivo in actual patients with Parkinson's disease and related disorders - Helps readers understand the in vivo pathology and pathophysiology in Parkinson's disease and in a number of related disorders - Discusses the association between clinical symptoms, clinical progression, and molecular, structural, and functional changes in the brain of patients with Parkinson's and related disorders

This book, now in its third, completely revised and updated edition, offers a critical approach to the challenging interpretation of the latest research data obtained using functional neuroimaging in whiplash injury. Such a comprehensive guide to recent and current international research in the field is more necessary than ever, given that the confusion regarding the condition and the medicolegal discussions surrounding it have increased further despite the publication of much literature on the subject. In recent decades especially the functional imaging methods – such as single-photon emission tomography, positron emission tomography, functional MRI, and hybrid techniques – have demonstrated a variety of significant brain alterations. Functional Neuroimaging in Whiplash Injury - New Approaches covers all aspects, including the imaging tools themselves and the various methods of image analysis. Details on biomechanics, including the finite element method and facts on historical whiplash experiments and crash tests have now been added to this new edition. The book will continue to help physicians, patients and their relatives and friends, and others to understand this condition as a disease.

This book serves as a reference and comprehensive guide for PET/MR neuroimaging. The field of PET/MR is rapidly evolving, however, there is no standard resource summarizing the vast information and its potential applications. This book will guide neurological molecular imaging applications in both clinical practice and the research setting. Experts from multiple disciplines, including radiologists, researchers, and physicists, have collaborated to bring their knowledge and expertise together. Sections begin by covering general considerations, including public health and economic implications, the physics of PET/MR systems, an overview of hot lab and cyclotron, and radiotracers used in neurologic PET/MRI. There is then coverage of each major disease/systemic category, including dementia and neurodegenerative disease, epilepsy localization, brain tumors, inflammatory and infectious CNS disorders, head and neck imaging, as well as vascular hybrid imaging. Together, we have created a thorough, concise and up-to-date textbook in a unique, user-friendly format. This is an ideal guide for neuroradiologists, nuclear medicine specialists, medical physicists, clinical trainees and researchers.

Medical imaging grows to be a broad and modern scientific field. Imaging principles, methods and applications are important topics in this field. While applications and the generalization of techniques start with and rely on theoretical development and novel methodology, introduction and instructions of relatively new ideas, concepts and methods are of pivotal importance to students, beginners and general clinical practitioners in this field. Functional MRI (fMRI) has been widely used for the past 30 years to investigate brain functional changes under physiologic challenges or disease conditions in contrast to a resting state. The physiological contributors to the fMRI signal changes include the blood-oxygenation-dependent level (BOLD) effect and in-flow effect such as the increment in local CBF and arterial oxygenation. Improvement of spatiotemporal resolution of fMRI to enhance neuronal activity specificity and pinpoint the microvasculature activation is the ultimate goal. fMRI functional activity/connectivity and graph theory-based connectome analyses with a multiplex fast imaging technique are recently developed new techniques to provide both a whole-picture and regional specialization of brain resource utilization in a systematic way. The integration of neuroscience and mathematical as well as physical and physiological metrics also promote the innovation and applications of multi-modal imaging equipment development and multi-parametric utilizations in clinical environments, including disease diagnosis and treatment. The aim of this book is intended to provide a whole picture of new fMRI imaging methodological developments from principles to applications, to both beginners and experts in biomedical imaging and healthcare. Several fundamental principles and metrics including BOLD, microvasculature detection and fMRI/EEG coupling will be presented together with some new and up-to-date analytical methods. The conventional statistical methods and relatively new methods of wavelets, dynamic linear correlation coefficients, independent component analysis, EEG source imaging and multi-modal integration will be covered. The authors hope that this book will capture the interests of colleagues in the medical imaging field and could help convey the methodological, technical and developmental resources of neuroimaging applications. This book will provide the current state-of-the-art and frontiers of neuroimaging techniques in basic science and clinical neuroscience research. The authors will present some forefront and interesting multi-dimensional imaging techniques to serve as a textbook and reference manual in fMRI methodological training as well as in the research field. Several distinct imaging perspectives, including cutting-edge imaging methods from acquisition to data analysis as well as multi-modal and multi-parametric quantifications will be described. The relatively new and advanced principles and methods together with interesting examples and application demonstrations would hopefully contribute to the medical imaging teaching and research field and could help facilitate the generalization, interpretation and applications of the proposed neuroimaging methods.

A revealing insider's account of the power—and limitations—of functional MRIThe ability to read minds has long been a fascination of science fiction, but revolutionary new brain-imaging methods are bringing it closer to scientific reality. The New Mind Readers provides a compelling look at the origins, development, and future of these extraordinary tools, revealing how they are increasingly being used to decode our thoughts and experiences—and how this raises sometimes troubling questions about their application in domains such as marketing, politics, and the law.Russell Poldrack takes readers on a journey of scientific discovery, telling the stories of the visionaries behind these breakthroughs. Along the way, he gives an insider's perspective on what is perhaps the single most important technology in cognitive neuroscience today—functional magnetic resonance imaging, or fMRI, which is providing astonishing new insights into the contents and workings of the mind. He highlights both the amazing power and major limitations of these techniques and describes how applications outside the lab often exceed the bounds of responsible science. Poldrack also details the unique and sometimes disorienting experience of having his own brain scanned more than a hundred times as part of a landmark study of how human brain function changes over time.Written by one of the world's leading pioneers in the field, The New Mind Readers cuts through the hype and misperceptions surrounding these emerging new methods, offering needed perspective on what they can and cannot do—and demonstrating how they can provide new answers to age-old questions about the nature of consciousness and what it means to be human.

This book combines classic MR anatomy with current understanding of human brain function. Recent advances in neuroscience have highlighted the importance of correlating brain anatomy with underlying brain function, since the brain contains a highly sophisticated organization of anatomical and functional relationships that are not readily “visible” with standard imaging. The use of magnetic resonance imaging is rapidly increasing in the field of neuroscience, and remains at the forefront for offering insights into the normal and pathologic structure and function of the human brain. The relatively recent concepts of structural and functional connectivity make it even more important to visualize the brain as a whole rather than looking at its individual parts. This holistic approach is vital in understanding concepts such as neuroplasticity that are currently incorporated into physical and cognitive rehabilitation programs for patients with stroke or neurodegenerative diseases. Ultimately this combined approach may reduce both overdiagnosis and misdiagnosis when integrated into routine clinical routine. This book will be of interest to neuroradiologists, general radiologists and neurologists alike, as well as medical students, residents and fellows.

MRI has emerged as a powerful way of studying in-vivo brain structure and function in both healthy and disease states. Whilst new researchers may be able to call upon advice and support for acquisition from operators, radiologists and technicians, it is more challenging to obtain an understanding of the principles of analysing neuroimaging data. This is crucial for choosing acquisition parameters, designing and performing appropriate experiments, and correctly interpreting the results. This primer gives a general and accessible introduction to the wide array of MRI-based neuroimaging methods that are used in research. Supplemented with online datasets and examples to enable the reader to obtain hands-on experience working with real data, it provides a practical and approachable introduction for those new to the neuroimaging field. The text also covers the fundamentals of what different MRI modalities measure, what artifacts commonly occur, the essentials of the analysis, and common'pipelines'including brain extraction, registration and segmentation. As it does not require any background knowledge beyond high-school mathematics and physics, this primer is essential reading for anyone wanting to work in neuroimaging or grasp the results coming from this rapidly expanding field. The Oxford Neuroimaging Primers are short texts aimed at new researchers or advanced undergraduates from the biological, medical or physical sciences. They are intended to provide a broad understanding of the ways in which neuroimaging data can be analyzed and how that relates to acquisition and interpretation. Each primer has been written so that it is a stand-alone introduction to a particular area of neuroimaging, and the primers also work together to provide a comprehensive foundation for this increasingly influential field.

This book describes the latest modalities such as tau PET imaging for diagnosis of Alzheimer's disease and other dementias, and also provides information on handling and analyzing imaging data that is not found in other books. In addition, it introduces routine imaging studies in the management of dementia in Japan. The prevalence of dementia has increased over the past few decades, either because of greater awareness and more accurate diagnosis, or because increased longevity has created a larger population of the elderly, the age group most commonly affected. Although only clinical assessment can lead to a diagnosis of dementia, neuroimaging in dementia is recommended by most clinical guidelines, and its adjunct role has traditionally been to exclude a mass lesion rather than to support a specific diagnosis. Neuroimaging may be also helpful for developing new strategies to achieve diagnoses as early as possible for therapies aimed at slowing the progression of neurodegenerative diseases manifesting dementia. Under these conditions, all clinicians and researchers who are involved in neuroimaging for dementia should decide which patients to scan, when imaging patients is most useful, which modality to use, how to handle imaging data from many institutions, and which analytical tool to use. This edition comprises contributions from leading Japanese experts in their fields.

Finding the Nerve: The Story of Impedance Neurography discusses research that elucidates the nature of nerve simulation via externally applied electrical fields, and how it has led to an entirely new understanding of neuronal cell membrane biophysics and defined a novel nerve imaging technology. It details how these discoveries came about and the nature of research that derives from unexplained clinical observations. The primary technology, impedance neurography, is a wholly new way of nerve-specific visualization in 2-D or 3-D, with the ability to define both normal and abnormal functioning of nerves, heretofore unavailable from techniques such as MRI neurography. This is of particular importance with respect to the obesity epidemic where physicians performing nerve-related procedures cannot use ultrasound visualization due to the depth limitations of that technology. - Focuses on nerve stimulation mechanics and neuronal cell membrane biophysics - Defines a nerve-specific imaging technology and issues with current nerve stimulation devices - Addresses inaccuracies in the understanding of nerve stimulation and provides a new understanding of neuronal cell membrane biophysics - Provides for nerve-specific visualization in 2-D or 3-D, with the novel ability to define both normal and abnormal functioning of nerves

Authored by renowned neuro-radiologist Steven P. Meyers, Differential Diagnosis in Neuroimaging: Brain and Meninges is a stellar guide for identifying and diagnosing brain pathologies based on location and neuroimaging results. The succinct text reflects more than 25 years of hands-on experience gleaned from advanced training and educating residents and fellows in radiology, neurosurgery, and neurology. The high-quality MRI, CT, PET, PET/CT, conventional angiography, and X-ray images have been collected over Dr. Meyers's lengthy career, presenting an unsurpassed visual learning tool.The distinctive'three-column table plus images'format is easy to incorporate into clinical practice, setting this book apart from larger, disease-oriented radiologic tomes. The layout enables readers to quickly recognize and compare abnormalities based on high-resolution images.Key HighlightsTabular columns organized by anatomical abnormality include brain imaging findings and a summary of key clinical data that correlates to the imagesComprehensive imaging of the brain, ventricles, meninges, and neurovascular system in both children and adults, including congenital/developmental anomalies and acquired diseaseMore than 1,900 figures illustrate the radiological appearance of intracranial lesions, masses, neurodegenerative disorders, ischemia and infarction, and moreThis visually rich resource is a must-have diagnostic tool for radiologists, neurosurgeons, and neurologists, and residents and fellows. The highly practical format makes it ideal for daily rounds, as well as a robust study guide for physicians preparing for board exams.

A unique, easy-to-use, and definitive guide to diagnostic spine imagingAuthored by renowned neuro-radiologist Steven P. Meyers, Differential Diagnosis in Neuroimaging: Spine is a stellar guide for identifying and diagnosing cervical, thoracic, lumbar, and sacral spine anomalies based on location and neuroimaging results. The succinct text reflects more than 25 years of hands-on experience gleaned from advanced training and educating residents and fellows in radiology, neurosurgery, and orthopaedic surgery. The high-quality MRI, CT, and X-ray images have been collected over Dr. Meyers's lengthy career, presenting an unsurpassed visual learning tool.The distinctive'three-column table plus images'format is easy to incorporate into clinical practice, setting this book apart from larger, disease-oriented radiologic tomes. This layout enables readers to quickly recognize and compare abnormalities based on high-resolution images.Key HighlightsTabular columns organized by anatomical abnormality include imaging findings and a summary of key clinical data that correlates to the imagesCongenital/developmental abnormalities, spinal deformities, and acquired pathologies in both children and adultsLesions organized by region including dural, intradural extramedullary, extra-dural, and sacrumMore than 600 figures illustrate the radiological appearance of spinal tumors, lesions, deformities, and injuriesSpinal cord imaging for the diagnosis of intradural intramedullary lesions and spinal traumaThis visually rich resource is a must-have diagnostic tool for trainee and practicing radiologists, neurosurgeons, neurologists, physiatrists, and orthopaedic surgeons who specialize in treating spine-related conditions. The highly practical format makes it ideal for daily rounds, as well as a robust study guide for physicians preparing for board exams.

An introduction to Neuroimaging and Neurophysiology in Psychiatry, this book explains the basic physics and physiology behind the main techniques of neuroimaging, including MRI and PET, and non-invasive neurophysiology. This title covers all the clinically relevant aspects of neuroimaging and neurophysiology methods. It includes individual chapters on techniques, diagnostic disease markers, and neurophysiological treatments to ensure psychiatrists are familiar with the clinical relevance of reported abnormalities. With the latest research, Neuroimaging and Neurophysiology in Psychiatry is an invaluable and easy-to-read reference that will help practising psychiatrists in the evaluation of the use of neuroimaging methods in clinical, research, and forensic settings.

Neuroimaging, Part One, a text from The Handbook of Clinical Neurology illustrates how neuroimaging is rapidly expanding its reach and applications in clinical neurology. It is an ideal resource for anyone interested in the study of the nervous system, and is useful to both beginners in various related fields and to specialists who want to update or refresh their knowledge base on neuroimaging. This first volume specifically covers a description of imaging techniques used in the adult brain, aiming to bring a comprehensive view of the field of neuroimaging to a varying audience. It brings broad coverage of the topic using many color images to illustrate key points. Contributions from leading global experts are collated, providing the broadest view of neuroimaging as it currently stands. For a number of neurological disorders, imaging is not only critical for diagnosis, but also for monitoring the effect of therapies, and the entire field is moving from curing diseases to preventing them. Most of the information contained in this volume reflects the newness of this approach, pointing to this new horizon in the study of neurological disorders. - Provides a relevant description of the technologies used in neuroimaging, including computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), and several others - Ideal resource for anyone studying the nervous system, from beginners to specialists interested in recent advances in neuroimaging of the adult brain - Discusses the application of imaging techniques to the study of brain and spinal cord disease and its use in various syndromes - Contains vibrant, colorful images to illustrate key points

Image-Guided Neurosurgery provides readers with an update on the revolutionary improvements in imaging and visualization relating to neurosurgery. From the development of the pneumoencephalogram, to the operating microscope, to cross sectional imaging with CT and later MRI, to stereotaxy and neuronavigation, the ability to visualize the pathology and surrounding neural structures has been the driving factor leading surgical innovation and improved outcomes. The book provides a comprehensive reference on the application of contemporary imaging technologies used in neurosurgery. Specific techniques discussed include brain biopsies, brain tumor resection, deep brain stimulation, and more. The book is ideal for neurosurgeons, interventional radiologists, neurologists, psychiatrists, and radiologists, as well as technical experts in imaging, image analysis, computer science, and biomedical engineering. - A comprehensive reference on image-guided neurosurgery - Includes coverage of neuronavigation in cranial surgery and advanced imaging, including functional imaging, adoption of intra-operative MRI and emerging technologies - Covers all image-guided neurosurgery tools, including robotic surgical devices - Ideal reference for topics relating to neurosurgery, imaging, stereotaxis, radiosurgery, radiology, epilepsy, MRI, the use of medical robotics, lasers, and more

Ideal for anyone with an interest in the increasing role of brain imaging in understanding pain perception and pain mechanisms, this unique, full-color resource thoroughly covers technical advances in the field as well as potential new applications. Dozens of worldwide experts first demystify the technological concepts that are crucial for proper understanding and interpretation of neuroimaging findings, then explore new advances in understanding brain mechanisms of pain, in human as well as animal models.

Cardiovascular and Neurovascular Imaging: Physics and Technology explains the underlying physical and technical principles behind a range of cardiovascular and neurovascular imaging modalities, including radiography, nuclear medicine, ultrasound, and magnetic resonance imaging (MRI). Examining this interdisciplinary branch of medical imaging from a

Interpret the complexities of neuroanatomy like never before with the unparalleled coverage and expert guidance from Drs. Srinivasan Mukundan and Thomas C. Lee in this outstanding volume of the Netter's Correlative Imaging series. Beautiful and instructive Netter paintings and illustrated cross-sections created in the Netter style are presented side by side high-quality patient images and key anatomic descriptions to help you envision and review intricate neuroanatomy. - Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. - View the brain, spinal cord, and cranial nerves, as well as head and neck anatomy through modern imaging techniques in a variety of planes, complemented with a detailed illustration of each slice done in the instructional and aesthetic Netter style. - Find anatomical landmarks quickly and easily through comprehensive labeling and concise text highlighting key points related to the illustration and image pairings. - Correlate patient data to idealized normal anatomy, always in the same view with the same labeling system.

Neuroimaging has had an enormous impact on the way human cognition is studied in vivo. With the advent of fMRI, scientists have been able to ask questions regarding individual differences which could not have been addressed with PET. These are particularly important for studying developmental disorders, such as dyslexia, because research suggests that participants with dyslexia (DPs) form a heterogeneous population. This book discusses neural correlation between reading deficits in individuals with developmental dyslexia. It also includes topics on electrical imaging in neuropsychiatry; prenatal magnetic resonance imaging of the brain and spine; and normal pressure hydrocephalus.

This quick reference guide for medical students and residents presents over sixty clinical case studies of major neurological conditions and their associated neuroimaging characteristics. A primer on the fundamental physics which underlie neuroimaging techniques is also provided. The content is organized by pathology type and the structure of every topic is similar to help the reader develop his or her thinking process in a stepwise fashion and to provide a rational approach to imaging interpretation. Neuroradiology in Clinical Practice is aimed at medical students and residents doing their rotations in neurology, internal medicine, emergency medicine, and family medicine, but will also be useful for allied health professionals, nurse practitioners, physician assistants and other primary medical care providers.

Dementia is a massive and increasing global problem, with the current prevalence anticipated to double every 20 years as people live longer. Neuroimaging in dementia is recommended by most clinical guidelines and its role has traditionally been to exclude a mass lesion, rather than to support a specific diagnosis. All radiologists will be aware of a steady rise in the number of requests for brain imaging in old people, but what can imaging reliably tell us and what kind of imaging should we use? In affluent societies we now have a range of structural and molecular brain imaging techniques at our disposal, with specific ligands and sophisticated image analysis techniques now available for clinical use. However, we have difficulty justifying which patients to scan, using which modality and when. We know that Alzheimer's disease is the most common neuropathology contributing to a diagnosis of Alzheimer's disease but we also know from large post-mortem studies that most brain pathology in those who have died with a diagnosis of dementia is mixed. Thus understanding different diseases that can cause dementia, how these co-exist or interact and appreciating that not all dementia is Alzheimer's disease is important. Equally important is awareness of individual differences in response to a neuropathological burden and what factors provide resilience against dementia that might be maximized to reduce or postpone its impact. This issue draws together contributions from experts in their fields to provide clarity to the topic in a comprehensive collection of articles.

Intraoperative imaging technologies have taken an ever-increasing role in the daily practice of neurosurgeons and the increasing attention and interest necessitated international interaction and collaboration. The Intraoperative Imaging Society was formed in 2007. This book brings together highlights from the second meeting of the Intraoperative Imaging Society, which took place in Istanbul-Turkey from June 14 to 17, 2009. Included within the contents of the book is an overview of the emergence and development of the intraoperative imaging technology as well as a glimpse on where the technology is heading. This is followed by in detail coverage of intraoperative MRI technology and sections on intraoperative CT and ultrasonography. There are also sections on multimodality integration, intraoperative robotics and other intraoperative technologies. We believe that this book will provide an up-to date and comprehensive general overview of the current intraoperative imaging technology as well as detailed discussions on individual techniques and clinical results.

Recent advances in neuroimaging and genetics technologies have enhanced our understanding of neurodevelopmental disorders in adults. The authors in this volume not only discuss such advances as they apply to adults with learning disorders, but also address their translation into clinical practice. One cluster of chapters addresses developmental concerns as children and adolescents with learning disorders approach young adulthood. Experts discuss dyslexia, language-based and writing disorders, perhaps the most widely studied group of learning disorders, from the point of view of neuroimaging and genetic underpinnings. Chapters on the neuroscience of nonverbal, math and executive function disorders are also included.Clinically-oriented chapters with case studies, recommendations for accommodation, and considerations for evaluation follow. Study of specialized populations - such as late high school students, college, medical and law students - further demonstrate how our expanded knowledge base may be applicable to clinical practice. The heterogeneity of adults with learning disorders, the complexity of their clinical presentation and co-existing disorders are addressed from both a scientific and clinical point of view demonstrating how empirical research and clinical practice inform each other.This volume will enhance the practice of clinicians and educators working with adults with neurodevelopmental disorders, as well as providing essential current information for researchers of adults with learning disorders.

Windows to the Brain is the only book to synthesize neuroanatomical and imaging research as it pertains to selected neuropsychiatric diseases, containing all of the'Windows to the Brain'papers published from 1999-2006 in the Journal of Neuropsychiatry and Clinical Neurosciences. These reader-friendly summaries by more than sixty contributors present modern imaging techniques that assist in the diagnosis of neuropsychiatric illness, enhanced by easily understood color graphics of the neuroanatomical circuits of behavior, memory, and emotion. They provide a basic understanding of how to apply a variety of imaging techniques to the study of adult neuropsychiatric disease and how to use neuroimaging to assist in diagnostic work-ups for conditions ranging from sleep disorders to epilepsy to borderline personality.Integrated, color-coded graphics present functional anatomical information in a manner that promotes understanding and use in clinical practice, while the text encompasses a wide range of diseases and injuries across the adult lifespan. The book is organized into four sections that will help readers increase their appreciation of the wide range of research and clinical applications for imaging in neuropsychiatry: chapters on imaging techniques discuss underlying principles, strengths and weaknesses, and applications; chapters on specific diseases demonstrate a range of investigative techniques; anatomy/circuit chapters focus on particular brain structures or functional neuropsychiatric circuits; and final chapters present image-based approaches to understanding or selecting treatment options. Some of the applications described are: • Use of fMRI in posttraumatic stress disorder to reveal the delicate balance between the structures of the emotion and memory tracks;• Use of high-resolution MRI and nuclear imaging to distinguish between panic disorder and simple partial seizure disorder;• Use of functional imaging studies to detect corticobasal degeneration, as a means of better understanding dementia;• Use of newer imaging techniques in identifying progressive multifocal leukoencephalopathy, to enable more rapid and reliable tailoring of individual therapy for HIV;• Use of functional neuroimaging in the study of fear, in order to better understand and treat anxiety-based psychiatric disorders;• Use of neuroimaging studies in conversion disorder, showing implications for the disruption of selfhood in dissociative identity disorder and schizophrenia;• Use of FDG-PET scans to look for predictors of treatment response in childhood-onset obsessive-compulsive disorder. Windows to the Brain can help bring less-experienced readers up to speed on advanced imaging and anatomical details that pertain to the modern practice of neuropsychiatry. It is must-reading for specialists in neuropsychiatry and cognitive/behavioral neurology, or for general psychiatrists with an interest in neuroimaging.

The rate of development in neuroimaging is so rapid that it is almost impossible to predict very far into the future in trying to understand this influence. The availability of technologies that make it possible to investigate, even in real time, the neural regions and systems that are functionally related disorders is having a transforming impact on the discipline. This book presents findings by some of the principal researchers in the field and who are working at the cutting-edge in applying neuroimaging to communication disorders.

Although the field of Neuro-Oncology has grown considerably in the last 10 to 15 years and has a rather extensive literature, there are no comprehensive,'single-source books that summarize the current literature and future trends of neuroimaging in neuro-oncology. This book covers this topic in more comprehensive fashion, making it an important addition to the armamentarium of physicians that care for patients with brain tumors and other neuro-oncological disorders. Well-founded in basic science, it includes chapters that provide an overview of relevant background material in critical areas such as physics, contrast agents, ultra-high field brain MRI, and molecular imaging.

- El presente manual, realizado por autores de prestigio tanto nacionales como internacionales, se centra en el estudio de las técnicas de neuroimagen funcional y del funcionamiento cerebral, tema del que hay una gran carencia de obras en lengua castellana. - Esta obra responde a preguntas como ¿Qué técnicas permiten aproximarnos al estudio del funcionamiento del cerebro? ¿Cuáles son sus posibilidades y limitaciones? ¿Qué resultados nos han dado en el estudio de los procesos cognitivos?, con un profundo rigor científico. - Consta de dos secciones bien diferenciadas. En la primera parte, dedicada a las técnicas, se describen las diferentes metodologías de estudio: microscopia electrónica, RM, en sus diversas variantes, PET, SPECT, EEG, MEG y algunas técnicas de estimulación, como la estimulación eléctrica cortical y la estimulación magnética transcraneal de alto y bajo campo. En la segunda parte, en la que se describen los Procesos, se hace una aproximación a las aplicaciones de estas técnicas en el campo de la neurociencia cognitiva y en concreto en el conocimiento de los sustratos neuronales de la memoria, la atención, el lenguaje, las funciones ejecutivas, el movimiento, la percepción, la emoción, así como las aproximaciones al estudio del desarrollo, la dislexia, las enfermedades psiquiátricas y la plasticidad en pacientes con daño cerebral. - Libro de enorme utilidad para estudiantes de psicología, así como para los de la carrera de medicina, y especialmente para residentes de neurología, neurocirugía, psiquiatría, radiología, neurofisiología y geriatría. Se trata igualmente de un perfecto manual de consulta para profesionales, incluso para los técnicos que manejan equipos de neurofisiología, radiología y medicina nuclear. - El comité editorial de la Universidad Nacional de Educación a Distancia ha dado su visto de calidad a esta obra. - Avalada por el comité editorial de la Universidad Nacional de Educación a Distancia, esta obra se centra en el estudio de las técnicas de neuroimagen funcional y del funcionamiento cerebral, tema del que hay una gran carencia de obras en lengua castellana. - Consta de dos secciones bien diferenciadas: en la primera parte, dedicada a las técnicas, se describen las diferentes metodologías de estudio: microscopia electrónica, RM, en sus diversas variantes, PET, SPECT, etc. En la segunda parte, se hace una aproximación a las aplicaciones de estas técnicas. - De enorme utilidad para estudiantes y profesionales de estas disciplinas, e incluso para los técnicos que manejan equipos de neurofisiología, radiología y medicina nuclear.

Comprised of two separate volumes, Neuroimaging provides a state-of-the-art review of a broad range of neuroimaging techniques applied to both clinical and research settings. The breadth of the methods covered is matched by the depth of description of the theoretical background. Part B covers the application of neuroimaging in both research and clinical settings for the study of anxiety disorders, dementia, depression, schizophrenia, functional somatic syndromes, stroke, and multiple sclerosis using a range of neuroimaging modalities including CT, PET, SPECT, DTI, structural MRI and fMRI. One chapter is devoted to the study of brain development using structural MRI, and one chapter to the study of pediatric neurobehavioral disorders using fMRI. One of the most exciting recent applications of neuroimaging to the area of genetics is covered, and with the theory and application of neuroreceptor imaging in psychiatry, forms the final two chapters. The two parts of Neuroimaging complement each other providing in-depth information on a broad range of routine and cutting edge techniques that is not available in any other text. This book is superbly written and beautifully illustrated by contributors working at the top of their chosen specialty. - Presents recent applications of neuroimaging to the area of genetics - Discusses the study of brain development using structural MRI - Includes chapters on the theory and application of neuroreceptor imaging in psychiatry

Consisting of two separate volumes, Neuroimaging provides a state-of-the-art review of a broad range of neuroimaging techniques applied to both clinical and research settings. The breadth of the methods covered is matched by the depth of description of the theoretical background. Part A focuses on the cutting edge of research methodologies, providing a foundation for both established and evolving techniques. These include voxel-based morphometry using structural MRI, functional MRI, perfusion MRI, diffusion tensor imaging, near-infrared spectroscopy and the technique of combining EEG and fMRI studies. Two chapters are devoted to describing methods for studying brain responses and neural models, focusing on functional connectivity, effective connectivity, dynamic causal modeling, and large-scale neural models. The important role played by brain atlases in facilitating the study of normal and diseased brain populations is described in one chapter, and the concept of neuroimaging data bases as a future resource for scientific discovery is elucidated in another. The two parts of Neuroimaging complement each other providing in-depth information on a broad range of routine and cutting edge techniques that is not available in any other text. This book is superbly written and beautifully illustrated by contributors working at the top of their chosen specialty.• Serves as an up-to-date review of cutting-edge neuroimaging techniques • Exquisitely illustrated • Authoritatively written by leading researchers

Methods in Neurosciences, Volume 3: Quantitative and Qualitative Microscopy is a collection of papers that deals with microscopic techniques in statistical measures. This volume describes microscopy using sophisticated stains and dyes to advance observation of tests and experiments. Section I describes autoradiography including micro chemical methods, high-resolution autoradiography, and single- or double-label quantitative autoradiography for use in imaging of brain activity patterns or determining cerebral physiology. Section II discusses the quantification of structures through statistical and computational methods including dynamic video imaging technology. Section III explains the use of tracers, toxins, or dyes in tracing neuronal connections. One paper addresses the use of small injections of axonally transported fluorescent tracers. Section IV explains staining technology such as using the silver impregnation method for frozen sections of human nervous tissue that are gathered from tissues preserved in formalin. Section V addresses freezing techniques and those using freeze-fracture methods in neurobiology. The text also discusses cryoprotection and other freezing methods to control ice crystals found in fixed or unfixed brain tissues. Section VI presents the combined and high-resolution methods in polarization microscopy and microscopic investigations. Cellular biologists, micro-chemists, and scientific researchers in the field of micro- and cellular biology will appreciate this book.