1. Pseudolipoblastic Perineuroma: A Rare Histologi̇c Subtype.
- Author
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Erdem O, Corti B, Paolo Salamone F, Piraccini BM, and Misciali C
- Subjects
- Humans, Biomarkers, Tumor analysis, Immunohistochemistry, Male, Female, Nerve Sheath Neoplasms pathology, Nerve Sheath Neoplasms chemistry
- Abstract
Abstract: Pseudolipoblastic perineurioma is a very uncommon variant of extraneural perineurioma, with only a limited number of cases documented in the medical literature. The most remarkable histopathologic characteristic is the existence of vacuolated cells that closely resemble lipoblasts; besides the presence of small, spindle shaped, or epithelioid perineurial cells. In this study, we present another case of pseudolipoblastic perineurioma, predominantly characterized by the presence of vacuolated "pseudolipoblastic" cells. The immunohistochemical expression of EMA, Glut-1, claudin-1, collagen type IV, and laminin as well as S-100 negativity is essential for the diagnosis to support the perineurial origin. Simple excision is the best treatment option for these benign tumors that do not recur or metastasize. It is crucial to recognize this rare entity to differentiate it from many other tumors characterized by prominent intracytoplasmic vacuoles., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2024
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