52,704 results on '"Neonatology"'
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2. Prospective Registration of Taiwan Neonatal Network (TNN)
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Taiwan Society of Neonatology
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- 2024
3. Swiss Neonatal Network & Follow-up Group (SwissNeoNet)
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Department of Neonatology, Children's Clinic, Cantonal Hospital Aarau, Switzerland, Department of Neuropaediatrics, Children's Clinic, Cantonal Hospital Aarau, Switzerland, Department of Neonatology, University of Basel Children's Hospital (UKBB), Switzerland, Department of Neuropaediatrics and Developmental Medicine, University of Basel Children's Hospital (UKBB), Switzerland, Department of Pediatrics, San Giovanni Hospital Bellinzona, Switzerland, Department of Neonatology, University Hospital Berne, Switzerland, Department of Neuropaediatrics, University Hospital Berne, Switzerland, Development and Pediatric Neurorehabilitation Center, Biel, Switzerland, Department of Neonatology, Children's Hospital Chur, Switzerland, Department of Neuropaediatrics, Children's Hospital Chur, Switzerland, Department of Neuropediatrics, Cantonal Hospital Fribourg, Switzerland, Department of Neonatology, University Hospital Lausanne (CHUV), Switzerland, Department of Child Development, University Hospital Lausanne (CHUV), Switzerland, Department of Neonatology, University Hospital Geneva (HUG), Switzerland, Division of Development and Growth, University Hospital Geneva (HUG), Switzerland, Neonatal and Paediatric Intensive Care Unit, Children's Hospital of Lucerne, Switzerland, Department of Neuropaediatrics, Children's Hospital of Lucerne, Switzerland, Department of Pediatrics, Cantonal Hospital Muensterlingen, Switzerland, Department of Pediatrics, Cantonal Hospital Neuchatel, Switzerland, Department of Neonatology, Cantonal Hospital St. Gallen, Switzerland, Neonatal and Paediatric Intensive Care Unit, Children's Hospital St. Gallen, Switzerland, Department of Child Development, Children's Hospital St. Gallen, Switzerland, Department of Neonatology, Cantonal Hospital Winterthur, Switzerland, Social Pediatrics Center, Cantonal Hospital Winterthur, Switzerland, University Hospital, Zürich, and University Children's Hospital, Zurich
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- 2023
4. A Study of General Movement Assessment and Its Association With Neurodevelopmental Outcome at Age 12 to 15 Months Among Term Neonates With Hyperbilirubinemia
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Vallamkonda, Nagaratna, Bandyopadhyay, Tapas, and Maria, Arti
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- 2024
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5. An Update on Patent Ductus Arteriosus and What is Coming Next
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Erdeve, Omer, Division of Neonatology, Department of Pediatrics, Okulu, Emel, Singh, Yogen, Sindelar, Richard, Oncel, Mehmet Yekta, Terrin, Gianluca, Boscarino, Giovanni, Bulbul, Ali, Sallmon, Hannes, Atasay, Begum, Ovali, Fahri, Clyman, Ronald I, Division of Neonatology, Loma Linda University School of Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Department of Women’s and Children’s Health, Uppsala University, Division of Neonatology, Buca Seyfi Demirsoy Training and Research Hospital, Department of Maternal and Child Health, University of Roma La Sapienza, Division of Neonatology, Department of Pediatrics University of Health Science, Department of Congenital Heart Disease/Pediatric Cardiology, Charité–Universitätsmedizin Berlin and Deutsches Herzzentrum Berlin, and Department of Pediatrics and Cardiovascular Research Institute, University of California San Francisco
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Paediatrics ,Biomedical and Clinical Sciences ,Infant Mortality ,Cardiovascular ,Pediatric ,Preterm ,Low Birth Weight and Health of the Newborn ,Perinatal Period - Conditions Originating in Perinatal Period ,patent ductus arteriosus ,preterm ,conservative ,medical ,surgical ,treatment - Abstract
Patent ductus arteriosus is the most common cardiovascular condition in preterm infants. There is a significant uncertainty about when and how to close ductus arteriosus in preterm infants due to a high spontaneous closure rate even in very immature preterm infants. Diagnosis and management of patent ductus arteriosus remain a challenge for both neonatologists and pediatric cardiologists. Researchers have tried to define a balance between an expectant approach and active treatment in selected infants. This review aimed to focus on the pathophysiology and management of patent ductus arteriosus and to make suggestions about approaches that might eliminate the association of morbidities with patent ductus arteriosus.
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- 2022
6. Predicting EONS in PPROM Patients (PEONS)
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Center of Fetal Surgery, University Hospital Halle Saale and Section for Neonatology and Pediatric Intensive Care, University Hospital Halle Saale
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- 2023
7. The Incidence of Treatment-requiring Retinopathy of Prematurity in Greece (GR-ROP)
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Athens General Children's Hospital "Pan.&Aglaia Kyriakou", Athens, Greece, Agia Sofia Children's Hospital, Athens, Greece, Attikon General Hospital, Athens, Greece, Iaso Neonatology Clinic, Athens, Greece, REA Maternity Hospital, Athens, Greece, Ippokratio General Hospital, Thessaloniki, Greece, General University Hospital of Patras, Greece, General University Hospital of Larisa, Greece, General University Hospital of Ioannina, Greece, General University Hospital of Heraklion, Greece, Venizeleio General Hospital of Heraklion, Greece, General University Hospital of Alexandroupoli, Greece, and Asimina Mataftsi, Associate Professor in Ophthalmology, Paediatric Ophthalmology and Strabismus
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- 2023
8. Complementary feeding in preterm infants: a position paper by Italian neonatal, paediatric and paediatric gastroenterology joint societies
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Maria Elisabetta Baldassarre, Raffaella Panza, Francesco Cresi, Guglielmo Salvatori, Luigi Corvaglia, Arianna Aceti, Maria Lorella Giannì, Nadia Liotto, Laura Ilardi, Nicola Laforgia, Luca Maggio, Paolo Lionetti, Carlo Agostoni, Luigi Orfeo, Antonio Di Mauro, Annamaria Staiano, Fabio Mosca, and On behalf of Italian Society of Paediatrics (SIP), Italian Society of Neonatology (SIN) and Italian Society of Paediatric Gastroenterology, Hepatology and Nutrition (SIGENP)
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Nutrition ,Complementary feeding ,Weaning [Mesh] ,Breastfeeding [Mesh] ,Breast milk [Mesh] ,Fortification ,Pediatrics ,RJ1-570 - Abstract
Abstract Nutrition in the first 1000 days of life is essential to ensure appropriate growth rates, prevent adverse short- and long-term outcomes, and allow physiologic neurocognitive development. Appropriate management of early nutritional needs is particularly crucial for preterm infants. Although the impact of early nutrition on health outcomes in preterm infants is well established, evidence-based recommendations on complementary feeding for preterm neonates and especially extremely low birth weight and extremely low gestational age neonates are still lacking. In the present position paper we performed a narrative review to summarize current evidence regarding complementary feeding in preterm neonates and draw recommendation shared by joint societies (SIP, SIN and SIGENP) for paediatricians, healthcare providers and families with the final aim to reduce the variability of attitude and timing among professionals.
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- 2022
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9. Restrictive dermopathy: A baby with taut skin, facial dysmorphism, joint contractures, and pulmonary hypoplasia
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Wei Di Ng, MBBS, MMED (Paed), Ai Ling Koh, MB, ChB, MRCPCH, MMED (Paed), Mark Jean Aan Koh, MBBS, DIP, MRCPCH, Dip Pract Derm (UK), DipDermatopathology (ICDP-UEMS, Austria), and Juin Yee Kong, MD (Jefferson, FAAP, Diplomate of American Board of Pediatrics) (Peds) (Neonatology)
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fetal akinesia deformation sequence ,laminopathy ,restrictive dermopathy ,ZMPSTE24 ,Dermatology ,RL1-803 - Published
- 2022
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10. The Effect of Delayed Cord Clamping and Milking on the Amount of Stem Cells In Preterm
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Turkish Neonatology Society and Merih Cetinkaya, Neonatologist
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- 2020
11. A Simulation Competition on Neonatal Resuscitation as a New Educational Tool for Pediatric Residents
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Lorenzo Zanetto, Francesco Cavallin, Nicoletta Doglioni, Benedetta Bua, Sandro Savino, Giuseppe De Bernardo, Simone Pratesi, Paolo Ernesto Villani, Gary M. Weiner, Daniele Trevisanuto, and on behalf of the Task Force on Neonatal Resuscitation of the Italian Society of Neonatology
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neonatology ,resuscitation ,simulation ,competition ,education ,training ,Pediatrics ,RJ1-570 - Abstract
Background: Training programs on resuscitation have been developed using simulation-based learning to build skills, strengthen cognitive strategies, and improve team performance. This is especially important for residency programs where reduced working hours and high numbers of residents can reduce the educational opportunities during the residency, with lower exposure to practical procedures and prolonged length of training. Within this context, gamification has gained popularity in teaching and learning activities. This report describes the implementation of a competition format in the context of newborn resuscitation and participants’ perceptions of the educational experience. Methods: Thirty-one teams of three Italian pediatric residents participated in a 3-day simulation competition on neonatal resuscitation. The event included an introductory lecture, familiarization time, and competition time in a tournament-like structure using high-fidelity simulation stations. Each match was evaluated by experts in neonatal resuscitation and followed by a debriefing. The scenarios and debriefings of simulation station #1 were live broadcasted in the central auditorium where teams not currently competing could observe. At the end of the event, participants received an online survey regarding their perceptions of the educational experience. Results: 81/93 (87%) participants completed the survey. Training before the event mostly included reviewing protocols and textbooks. Low-fidelity manikins were the most available simulation tools at the residency programs. Overall, the participants were satisfied with the event and appreciated the live broadcast of scenarios and debriefings in the auditorium. Most participants felt that the event improved their knowledge and self-confidence and stimulated them to be more involved in high-fidelity simulations. Suggested areas of improvement included more time for familiarization and improved communication between judges and participants during the debriefing. Conclusions: Participants appreciated the simulation competition. They self-perceived the educational impact of the event and felt that it improved their knowledge and self-confidence. Our findings suggest areas of improvements for further editions and may serve as an educational model for other institutions.
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- 2023
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12. Surveying family access: kangaroo mother care and breastfeeding policies across NICUs in Italy
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Claudia Artese, Fabrizio Ferrari, Silvia Perugi, Paola Cavicchioli, Giuseppe Paterlini, Fabio Mosca, and the Developmental Care Study Group of Italian Society and Neonatology
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Developmental care ,Parental access ,Premature newborn ,Breastfeeding ,Skin-to-skin contact ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Studies on the application of developmental care initiatives in Italian NICUs are rather scarce. We aimed to assess parental access to the NICUs and facilities offered to the family members and to test “the state of art” regarding kangaroo mother care (KMC) and breastfeeding policies in level III Italian NICUs. Methods A questionnaire both in paper and in electronic format was sent to all 106 Italian level III NICUs; 86 NICUs (i.e., 80% of NICUs) were completed and returned. The collected data were analysed. In addition, a comparison between the 2017 survey results and those of two previous surveys conducted from 2001 to 2006 was performed. Results In total, 53 NICUs (62%) reported 24-h open access for both parents (vs. 35% in 2001 and 32% in 2006). Parents were requested to temporarily leave the unit during shift changes, emergencies and medical rounds in 55 NICUs (64%). Some parental amenities, such as an armchair next to the crib (81 units (94%)), a room for pumping milk and a waiting room, were common, but others, such as family rooms (19 units (22%)) and adjoining accommodation (30 units (35%)), were not. KMC was practised in 81 (94%) units, but in 72 (62%), i.e., the majority of units, KMC was limited to specific times. In 11 (13%) NICUs, KMC was not offered to the father. The average duration of a KMC session, based on unit staff estimation, was longer in 24-h access NICUs than in limited-access NICUs. KMC documentation in medical records was reported in only 59% of questionnaires. Breastfeeding was successful in a small proportion of preterm infants staying in the NICU. Conclusion The number of 24-h access NICUs doubled over a period of 13 years. Some basic family facilities, such as a dedicated kitchen, rooms with dedicated beds and showers for the parents, remain uncommon. KMC and breastfeeding have become routine practices; however, the frequency and duration of KMC sessions reported by NICU professionals still do not meet the WHO recommendations.
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- 2021
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13. Is Paracetamol an Effective Treatment for Chronic Moderate Pain in the Newborn After Operative Vaginal Delivery?
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Neonatology and Obstetrics, University Hospital Inselspital Berne and University Hospital, Zürich
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- 2019
14. Management of oxygen saturation monitoring in preterm newborns in the NICU: the Italian picture
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Serafina Perrone, Maurizio Giordano, Giuseppe De Bernardo, Paola Lugani, Pasquale Sarnacchiaro, Gemma Stazzoni, Giuseppe Buonocore, Susanna Esposito, Maria Luisa Tataranno, and on behalf of the National Study Group of Neonatal Clinical Biochemistry of the Italian Society of Neonatology
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Neonate ,NICU ,Oxygen saturation ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Although many studies emphasize the importance of using oxygen saturation (SpO2) targets in the NICUs, there is a wide variability in used saturation ranges among centers. Primary aim was to draw a representative picture on how the management of oxygen monitoring is performed in the Italian NICUs. Second aim was to identify healthcare-professionals related factors associated with oxygen targeting in the preterm population. Methods Cross-sectional study with data collection via an electronic survey form. A questionnaire containing pre-piloted and open questions on monitoring and management of the SpO2 was administered to neonatologists across the network of the Italian Society of Neonatology. The questions focused on: the infrastructure, specific training, healthcare professionals and patients-related factors. The results of the survey were anonymously collected, summarized and analyzed. Results Out of 378 questionnaires, 93 were correctly filled. Thirty-six different SpO2 ranges were observed. Centers using written standard operating procedures on oxygen management and SpO2 monitoring maintained a correct average range of SpO2 90–95%, avoided hyperoxia and reconsidered saturation targets in relation to comorbidities. 39.8% of responders disabled alarms during neonatal care. One center used biomarkers for complete monitoring of neonatal oxygenation status. Conclusions There is considerable variation in SpO2 targets for preterm infants in the Italian NICUs. Standard operating procedures and specific training for health care personnel are the main factors playing a role for the correct maintenance of the recommended oxygen targets in preterms.
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- 2021
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15. Use of intravenous sodium bicarbonate in neonatal intensive care units in Italy: a nationwide survey
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Luca Massenzi, Roberto Aufieri, Silvia Donno, Rocco Agostino, Andrea Dotta, and on behalf of the Neonatal Pharmacotherapy Study Group of the Italian Society of Neonatology (SIN)
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Infant, newborn ,Sodium bicarbonate ,Acid-Base imbalance ,Surveys and questionnaires ,Drug therapy ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Metabolic Acidosis (MA) is a disturbance of the acid-base balance that can occur in preterm and critically ill term neonates due to different etiologies. Intravenous sodium bicarbonate (SB) has been traditionally used to correct such unbalance, despite the lack of evidence about its safety and efficacy. In literature, reported undesirable effects of treatment with SB in neonates include worsening of intracellular acidosis, impairment of myocardial function, cerebral blood flow fluctuations and intracranial hemorrhage. A national survey was conducted by the Neonatal Pharmacotherapy Study Group of the Italian Society of Neonatology with the aim to assess and describe attitudes and practices concerning the use of SB, particularly for the treatment of MA in Italian NICUs. Methods A questionnaire regarding treatment of MA and SB prescription habits was sent to the directors of 120 Italian NICUs from June 2017 to March 2018. Results The survey response rate was 97.5% (117/120 centers). Findings showed that in 55% of the surveyed NICUs (64/117 units) it is common practice to correct MA with intravenous SB. On the other hand, the remaining 45% of the units try to solve the metabolic disturbances adopting different approaches (improving perfusion, adjusting ventilation parameters or increasing blood volume). Moreover, to prevent the occurrence of MA, 37.6% of the NICUs (44/117) include buffer salts (lactate, acetate or both) in parenteral nutrition prescriptions. SB is also used as a treatment for other conditions, mainly pathologies with bicarbonate loss and tubular acidosis (respectively in 53.8 and 32.5% of the NICUs). Conclusion This survey showed how SB is a commonly used treatment for MA in more than half of Italian NICUs, with indications and prescription criteria that significantly vary across centers. Based on current knowledge, it is reasonable to suggest that the management of neonatal MA should be firstly directed to identify the underlying disorders. Thus, the use of SB should be reserved only for selected cases, also considering the severity of SB adverse effects and the lack of evidence about its efficacy. Guidance for the management of MA is required to harmonize practices and reduce the use of potentially inappropriate and unsafe treatments.
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- 2021
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16. Sustainable neonatal CLABSI surveillance: consensus towards new criteria in the Netherlands
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I. E. Heijting, T. A. J. Antonius, A. Tostmann, W. P. de Boode, M. Hogeveen, J. Hopman, and the Working Group on Neonatal Infectious Diseases of the Section of Neonatology of the Dutch Paediatric Society
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Central line-associated bloodstream infections (CLABSI) ,Catheter-related infections ,Cross infection ,Hospital-acquired infections (HAI) ,Neonatal intensive care unit (NICU) ,Newborn ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Central line-associated bloodstream infections (CLABSI) are a main focus of infection prevention and control initiatives in neonatal care. Standardised surveillance of neonatal CLABSI enables intra- and interfacility comparisons which can contribute to quality improvement. To date, there is no national registration system for CLABSI in neonatal care in the Netherlands and several criteria are used for local monitoring of CLABSI incidence rates. To achieve standardised CLABSI surveillance we conducted a consensus procedure with regard to nationwide neonatal CLABSI surveillance criteria (SC). Methods A modified Delphi consensus procedure for the development of nationwide neonatal CLABSI SC was performed between January 2016 and January 2017 in the Netherlands. An expert panel was formed by members of the Working Group on Neonatal Infectious Diseases of the Section of Neonatology of the Dutch Paediatric Society. The consensus procedure consisted of three expert panel rounds. Results The expert panel achieved consensus on Dutch neonatal CLABSI SC. Neonatal CLABSI is defined as a bloodstream infection occurring more than 72 h after birth, associated with an indwelling central venous or arterial line and laboratory confirmed by one or more blood cultures. In addition, the blood culture finding should not be related to an infection at another site and one of the following criteria can be applied: 1. a bacterial or fungal pathogen is identified from one or more blood cultures; 2. the patient has clinical symptoms of sepsis and 2A) a common commensal is identified in two separate blood cultures or 2B) a common commensal is identified by one blood culture and C-reactive protein level is above 10 mg/L in the first 36 h following blood culture collection. Conclusions The newly developed Dutch neonatal CLABSI SC are concise, specified to the neonatal population and comply with a single blood culture policy in actual neonatal clinical practice. International agreement upon neonatal CLABSI SC is needed to identify best practices for infection prevention and control.
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- 2021
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17. Furosemide use in Italian neonatal intensive care units: a national survey
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Valeria Anna Manfredini, Chiara Cerini, Antonio Clavenna, Andrea Dotta, Maria Letizia Caccamo, Alex Staffler, Luca Massenzi, Rossano Massimo Rezzonico, and on the behalf of study Group of Neonatal Pharmacoterapy of the Italian Society of Neonatology
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Furosemide ,Newborn ,Posology ,Off-label ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Furosemide is approved in full term neonates to treat edema associated with congestive heart failure, cirrhosis and renal diseases. It is often administered off-label in premature neonates, to treat respiratory conditions and at doses greater-than-recommended. We conducted a national survey on behalf of the Neonatal Pharmacotherapy Study Group of the Italian Society of Neonatology (SIN), to investigate its use in Italian neonatal intensive care units (NICUs), in conformity with current guidelines. Methods Between December 2016 and June 2017, a 14-item multiple-choice online questionnaire was sent to all NICU directors from the SIN directory. Gestational age, route of administration, posology, indications, referenced guidelines, adverse effects monitoring and the presence of Paediatric Cardiology or Cardiosurgery service on site were assessed. A chi-square test was performed 1) to evaluate differences in the distribution of responses between NICUs administering furosemide at doses higher-than-recommended; 2) to compare the proportion of NICUs administering furosemide at high doses in institutions with versus without a Paediatric Cardiology or Cardiosurgery service. Results The response rate was 50% (57/114). The intravenous and oral routes were chosen primarily; the intravenous administration in single doses predominated over continuous infusion. Its main therapeutic indications were congestive heart failure/overload (94.7%) and oligo-anuria (87.7%) however furosemide was also frequently used for broncopulmonary dysplasia (50.9%) and respiratory distress syndrome and/or transient tachypnea of the newborn (24.6%). In 28/57 NICUs furosemide was administered at doses higher-than-recommended. In most NICUs the same posology was used in term and preterm neonates. Compared to the total sample, a larger proportion of NICUs administering doses greater-than-recommended referenced current literature for reasons to do so (19.3 and 32.1% respectively). The presence of a Paediatric Cardiology or Cardiosurgery service on site did not correlate with the chosen posology. The majority of NICUs performed acoustic test and renal ultrasound for furosemide exposure greater than 2 weeks. Conclusions In Italian NICUs, furosemide is commonly prescribed to term and preterm newborns for label and unlabeled indications. Doses greater-than-recommended are frequently administered. Such use is not necessarily inappropriate. More research is required to assess the efficacy and safety of unlabeled use.
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- 2020
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18. Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far
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Domenico Umberto De Rose, Fiammetta Piersigilli, Maria Paola Ronchetti, Alessandra Santisi, Iliana Bersani, Andrea Dotta, Olivier Danhaive, Cinzia Auriti, and The Study Group of Neonatal Infectious Diseases of The Italian Society of Neonatology (SIN)
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Newborns ,COVID-19 ,Infants ,SARS-CoV-2 ,Coronavirus ,Pediatrics ,RJ1-570 - Abstract
Abstract Recently, an outbreak of viral pneumonitis in Wuhan, Hubei, China successively spread as a global pandemia, led to the identification of a novel betacoronavirus species, the 2019 novel coronavirus, successively designated 2019-nCoV then SARS-CoV-2). The SARS-CoV-2 causes a clinical syndrome designated coronavirus disease 2019 (COVID19) with a spectrum of manifestations ranging from mild upper respiratory tract infection to severe pneumonitis, acute respiratory distress syndrome (ARDS) and death. Few cases have been observed in children and adolescents who seem to have a more favorable clinical course than other age groups, and even fewer in newborn babies. This review provides an overview of the knowledge on SARS-CoV-2 epidemiology, transmission, the associated clinical presentation and outcomes in newborns and infants up to 6 months of life.
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- 2020
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19. Survey of PDA management in very low birth weight infants across Italy
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Benjamim Ficial, Iuri Corsini, Stefano Fiocchi, Federico Schena, Irma Capolupo, Rosa Maria Cerbo, Manuela Condò, Daniela Doni, Simona La Placa, Salvatore Porzio, Katia Rossi, Sabrina Salvadori, Marilena Savoia, and On the behalf of the Italian Study Group of Neonatal Cardiology of the Italian Society of Neonatology
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Survey ,Preterm infants ,PDA management ,Neonatologist performed echocardiography ,Pediatrics ,RJ1-570 - Abstract
Abstract Background The optimal management of PDA in very low birth weight (VLBW) infants is still controversial. Aim of our study was to investigate the management of PDA in the Italian neonatal intensive care units (NICU). Methods We conducted an on-line survey study from June to September 2017. A 50-items questionnaire was developed by the Italian Neonatal Cardiology Study Group and was sent to Italian NICUs. Results The overall response rate was 72%. Diagnosis of PDA was done by neonatologists, cardiologists or both (62, 12 and 28% respectively). PDA significance was assessed by a comprehensive approach in all centers, although we found a heterogeneous combination of parameters and cut-offs used. None used prophylactic treatment. 19% of centers treated PDA in the first 24 h, 60% after the first 24 h, following screening echocardiography or clinical symptoms, 18% after the first 72 h and 2% after the first week. In the first course of treatment ibuprofen, indomethacin and paracetamol were used in 87, 6 and 7% of centers respectively. Median of surgical ligation was 3% (1–6%). Conclusions Significant variations exist in the management of PDA in Italy. Conservative strategy and targeted treatment to infants older than 24 h with echocardiographic signs of hemodynamic significance seemed to be the most adopted approach.
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- 2020
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20. An Unusual Case of Severe Persistent Neonatal Thrombocytopenia in an Extremely Low Birth Weight, Extreme Preterm Neonate
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Mobin Paul MBBS, MD, DM, Ananthen Killikulangara Sadanandan MBBS, MD, Fellow in Neonatology, Latha Abraham MBBS, MD, Sophy Madany Pathrose MBBS, and Dasary Varghese MBBS
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Pediatrics ,RJ1-570 - Abstract
Neonatal thrombocytopenia is a common hematological problem but refractory thrombocytopenia is very rare in neonates. A systematic and diligent workup will result in arriving at the proper diagnosis and providing accurate management in rare causes of neonatal thrombocytopenia. We report a case of severe refractory thrombocytopenia in an extremely low birth weight (ELBW)/extreme preterm baby who presented with early onset severe thrombocytopenia associated with anemia and required multiple platelet transfusions. After ruling out COVID-19 infection, sepsis and neonatal alloimmune thrombocytopenia (NAIT), the cause for severe refractory thrombocytopenia was diagnosed as Type II congenital amegakaryocytic thrombocytopenia (CAMT) by bone marrow examination and MPL gene mutation studies.
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- 2021
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21. Neonatologist performed echocardiography (NPE) in Italian neonatal intensive care units: a national survey
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Iuri Corsini, Benjamim Ficial, Stefano Fiocchi, Federico Schena, Irma Capolupo, Rosa Maria Cerbo, Manuela Condò, Daniela Doni, Simona La Placa, Salvatore Porzio, Katia Rossi, Sabrina Salvadori, Marilena Savoia, and On Behalf of Study Group of Neonatal Cardiology of the Italian Society of Neonatology
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Neonatologist performed echocardiography ,Neonatal cardiology ,Functional echocardiography ,Neonatal intensive care ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Neonatologist performed echocardiography (NPE) has increasingly been used to assess the hemodynamic status in neonates. Aim of this survey was to investigate the utilization of NPE in Italian neonatal intensive care units (NICUs). Methods We conducted an on-line survey from June to September 2017. A questionnaire was developed by the Italian neonatal cardiology study group and was sent to each Italian NICU. Results The response rate was 77%. In 94% of Italian NICUs functional echocardiography was used by neonatologists, cardiologists or both (57, 15 and 28% respectively). All the respondents used NPE in neonates with patent ductus arteriosus and persistent pulmonary hypertension, 93% in neonates with hypotension or shock, 85% in neonates with perinatal asphyxia, 78% in suspicion of cardiac tamponade, and 73% for line positioning. In 30% of center, there was no NPE protocol. Structural echocardiography in stable and critically ill neonates was performed exclusively by neonatologists in 46 and 36% of center respectively. Conclusions NPE is widely used in Italian NICUs by neonatologists. Structural echocardiography is frequently performed by neonatologists. Institutional protocols for NPE are lacking. There is an urgent need of a formal training process and accreditation to standardize the use of NPE.
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- 2019
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22. Rethinking the neonatal transport ground ambulance
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Carlo Bellini, Martina de Biasi, Maurizio Gente, Luca A. Ramenghi, Roberto Aufieri, Diego Minghetti, Silvia Pericu, Martina Cavalieri, Niccolò Casiddu, and on behalf of the Neonatal Transport Study Group of the Italian Society of Neonatology (Società Italiana di Neonatologia, SIN)
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Neonatal transport ,Ground ambulance ,EU rules ,Pediatrics ,RJ1-570 - Abstract
Abstract Objectives This article describes the detailed project aimed to realize a dedicated ground ambulance for neonatal emergency transport service (NETS). To date, the European Community rules specify requirements for the design, testing, performance, and equipping of road ambulance used for transport and care of adult injured or ill patients, completely ignoring neonatal transport. Methods The project consisted of electric and gas supply planning, interior design taking into account ergonomic and occupant protection principles, both during travel and during medical care performances. Results A detailed project is presented. Main differences between European Type C ambulance and the new proposed Type D neonatal ground ambulance are the presence on board of air compressed cylinder, iNO cylinders and delivery system, phototheraphy, shock adsorbing stretcher support, cooling device, patient’s placenta (refrigeration box), and transcutaneous gas analyzer. Conclusion The European Community rules specify requirements for road ambulance used for transport and care of adult injured or ill patients, completely ignoring neonatal transport. This study describes the detailed project aimed to realize a dedicated ground ambulance for neonatal emergency transport service. This study demonstrated that it is not possible simply to adapt the currently dedicated ambulance for mobile intensive care and resuscitation services (actual type C European Community) in a modern dedicated NETS ambulance; it is of paramount importance suggesting to European Community to introduce a further ambulance type, to be identified type D, strictly reserved to neonatal transport activities.
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- 2019
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23. Neonatal respiratory support strategies for the management of extremely low gestational age infants: an Italian survey
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Flavia Petrillo, Camilla Gizzi, Gianfranco Maffei, Piero G. Matassa, Maria Luisa Ventura, Cinzia Ricci, Roberta Pastorino, Giovanni Vento, and on Behalf of Neonatal Pneumology Study Group Italian Society of Neonatology
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Survey ,Preterm infants ,Mechanical ventilation ,Non-invasive respiratory support ,Training ,Pediatrics ,RJ1-570 - Abstract
Abstract Background We aimed to survey Delivery Room and Neonatal Intensive Care Unit (NICU) respiratory strategies dedicated to the extremely low gestational age newborn (ELGAN – GA
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- 2019
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24. Nationwide survey of neonatal transportation practices in Italy
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Maurizio Gente, Roberto Aufieri, Rocco Agostino, Tiziana Fedeli, Maria Grazia Calevo, Paolo Massirio, Carlo Bellini, and on behalf of the Neonatal Transport Study Group of the Italian Society of Neonatology (SIN)
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Infant, newborn ,Intensive care, neonatal transport ,Perinatal care ,Regional medical programs ,Health services accessibility ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Despite regionalization of perinatal care provides for the “in utero” transfer of high-risk pregnancies, there will always be a number of neonates who undergo acute inter-facility transport. The presence of a well-organized Neonatal Emergency Transport Service (NETS) can prevent and reduce risks of transportation, especially for very preterm infants, and is therefore mandatory for any program of regionalization of perinatal care. Italian National Health System is highly decentralized and Regions are autonomous to structure, plan and delivery their regional health services. Consequently, organization models and resources available vary widely and significant regional differences in access and quality of health services have been reported in the past years. A national survey was conducted in 2015 by the neonatal transport study group of the Italian Society of Neonatology with the aim to describe neonatal transfer practices and to assess the Neonatal Emergency Transport Services (NETS) status in the 20 Italian regions. Methods A questionnaire regarding neonatal transfer practices and NETS activity for the previous year (2014) was sent to the 44 NETS operating in the 20 Italian regions. Demographic data were obtained from the Italian National Statistical Institute (ISTAT). Results The overall survey response rate was 100%. In 2014, only 12 (60%) of the 20 Italian regions were fully covered by NETS, 3 (15%) regions were partially covered, while neonatal transport was not available in 5 (25%) regions. Overall, in 2014, the 44 NETS operating in Italy transported a total of 6387 infants, including 522 (8.17%) having a gestational age
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- 2019
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25. Strategies for preventing group B streptococcal infections in newborns: a nation-wide survey of Italian policies
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Chryssoula Tzialla, Alberto Berardi, Claudio Farina, Pierangelo Clerici, Alessandro Borghesi, Elsa Viora, Paolo Scollo, Mauro Stronati, Task Force for group B streptococcal infections for the Italian Society of Neonatology, Italian Society of Obstetricians and Gynecologists, and Italian Association of Clinical Microbiologists
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Group B streptococcus ,GBS ,Survey ,Infection ,Neonate ,Newborn infant ,Pediatrics ,RJ1-570 - Abstract
Abstract Background There are no Italian data regarding the strategies for preventing neonatal group B streptococcal (GBS) infection. We conducted a national survey in order to explore obstetrical, neonatal and microbiological practices for the GBS prevention. Methods Three distinct questionnaires were sent to obstetricians, neonatologists and microbiologists. Questionnaires included data on prenatal GBS screening, maternal risk factors, intrapartum antibiotic prophylaxis, microbiological information concerning specimen processing and GBS antimicrobial susceptibility. Results All respondent obstetrical units used the culture-based screening approach to identify women who should receive intrapartum antibiotic prophylaxis, and more than half of the microbiological laboratories (58%) reported using specimen processing consistent with CDC guidelines. Most neonatal units (89 out of 107, 82%) reported using protocols for preventing GBS early-onset sepsis consistent with CDC guidelines. Conclusions The screening-based strategy is largely prevalent in Italy, and most protocols for preventing GBS early-onset sepsis are consistent with CDC guidelines. However, we found discrepancies in practices among centers that may reflect the lack of Italian guidelines issued by public health organizations.
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- 2017
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26. Complementary Feeding in the Preterm Infants: Summary of Available Macronutrient Intakes and Requirements
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Guglielmo Salvatori, Ludovica Martini, and the Study Group on Neonatal Nutrition and Gastroenterology—Italian Society of Neonatology
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complementary feeding ,weaning ,preterm infants ,macronutrients ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Limited data are available regarding the nutritional needs for preterm infants. In most cases, guidelines refer to the acquisition of neuromotor skills, adequate weight and corrected chronological age. While waiting for the establishment of specific nutritional indications for premature infants we proposed the weaning recommendations for term infants of the Italian Society of Human Nutrition with LARNs (Reference intake Levels of Nutrients and energy for the Italian population) of 2014, the Dietary Reference Values for nutrients of European Food Safety Authority (EFSA) of 2017 and the Nutrient Reference Values for Australia and New Zealand Including Recommended Dietary Intakes of 2017.
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- 2020
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27. Rethinking the neonatal transport ground ambulance
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Bellini, Carlo, de Biasi, Martina, Gente, Maurizio, Ramenghi, Luca A., Aufieri, Roberto, Minghetti, Diego, Pericu, Silvia, Cavalieri, Martina, Casiddu, Niccolò, and on behalf of the Neonatal Transport Study Group of the Italian Society of Neonatology (Società Italiana di Neonatologia, SIN)
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- 2019
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28. Nationwide survey of neonatal transportation practices in Italy
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Gente, Maurizio, Aufieri, Roberto, Agostino, Rocco, Fedeli, Tiziana, Calevo, Maria Grazia, Massirio, Paolo, Bellini, Carlo, and on behalf of the Neonatal Transport Study Group of the Italian Society of Neonatology (SIN)
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- 2019
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29. Neonatal respiratory support strategies for the management of extremely low gestational age infants: an Italian survey
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Petrillo, Flavia, Gizzi, Camilla, Maffei, Gianfranco, Matassa, Piero G., Ventura, Maria Luisa, Ricci, Cinzia, Pastorino, Roberta, Vento, Giovanni, and on Behalf of Neonatal Pneumology Study Group Italian Society of Neonatology
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- 2019
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30. Design and specific features of the Programme for Early Detection and Follow-Up of Full-Term and Preterm Children, Born Small for Their Gestational Age
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Stoyanova, Hristina, Trakia University, Stara Zagora, Mumdzhiev, Hristo, Petleshkova-Angelova, Penka, Medical University of Plovdiv, Krasteva-Vilmosh, Maya, Iotova, Violeta, Medical University of Varna, Pramatarova, Tanya, Neonatology Clinic, Dr. Ivan Seliminski Hospital, Sliven, Tsochev, Kaloyan, Krumova, Darina, Zlateva, Tanya, Medical University - Varna, Georgieva, Ralitsa, Medical University of Sofia, and Acknowledgements. The Program is run by the Bulgarian Neonatology Association and the Varna Pediatric Endocrine Society with support from The Pfizer Global Мedical Grants (ID: 64919053).
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small for gestational age, SGA, catch-up growth, short stature, timely diagnosis - Abstract
In 2007 the International Consensus for Management of Children Born Small for Their Gestational Age (SGA) was published. SGA birth is connected to many complications in different periods of life. Often in practice children born with small sizes are underestimated and not always referred timely to а pediatric endocrinologist. Thеse children represent а significant part of children with growth problems. In our country there is not enough information for the condition and algorithm for its follow-up. Having all this in mind, Varna Pediаtric Endocrine Society (VAPES) and Bulgarian Neonatology Association (BNА) created the Programme for Early Detection and Follow-Up of Full-Term and Pre-Term Children, Born SGA. The current publication presents the design of the study. The Programme is scientifically applied investigation for early detection of full-term and preterm SGA children, aiming to facilitate timely diagnosis of syndromes and conditions connected to SGA births and, if needed, to recommend additional testing, including genetic. Through the Programme we expect to update the data for the prevalence of SGA births and SGA children without postnatal catch-up in our country. At the end of the Programme, we will evaluate its cost-effectiveness and will create an algorithm for detection and treatment of these children.
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- 2022
31. Complementary Feeding in Preterm Infants: A Systematic Review
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Nadia Liotto, Francesco Cresi, Isadora Beghetti, Paola Roggero, Camilla Menis, Luigi Corvaglia, Fabio Mosca, Arianna Aceti, and on behalf of the Study Group on Neonatal Nutrition and Gastroenterology—Italian Society of Neonatology
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complementary feeding ,weaning ,preterm infants ,oral dysfunction ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Background: This systematic review summarizes available literature regarding complementary feeding (CF) in preterm infants, with or without comorbidities that may interfere with oral functions. Methods: A literature search was conducted in PubMed and the Cochrane Library. Studies relating to preterm infants (gestational age
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- 2020
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32. List of Contributors
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Agrawal, Pankaj B., Akhtar, Yasmin, Alallah, Jubara, Alhassen, Ziad, Altit, Gabriel, AlZubaidi, Abbas, Amlani, Lahin M., Antelo, Martin, Athalye-Jape, Gayatri, Badarch, Jargalsaikhan, Baer, Gerri, Bagga, Nitasha, Bahr, Timothy M., Bar-Cohen, Yaniv, M. Barr, Stephanie, Bauer, Andrew J., Bearer, Cynthia F., Beckman, Ross M., Beltempo, Marc, Bembea, Melania M., Berlin, Sheila, Berry, Shandeigh N., Bhandari, Vineet, Bhatia, Shaifali, Bhombal, Shazia, Bigelow, Elaine O., Blevins, Carley, Boppana, Suresh, Boss, Renee, Brooks, Sandra, Buonocore, Giuseppe, Burnsed, Jennifer, Calabria, Andrew C., Carrasco, Melisa, Carter, Brian S., Chandrasekharan, Praveen, Chavez-Valdez, Raul, Choleva, Lauryn, Christensen, Robert D., Chung, Wendy K., Coggins, Sarah A., Cooke, David W., Cummings, Laura, Currie, Erin R., Davidson, Joanne O., Davis, Jonathan M., Day-Richardson, Colby L., De Leon, Diva D., Dedhia, Kavita, Dendi, Alvaro, Deshpande, Anita, Dionne, Janis M., Donda, Keyur, Donohue, Lee, Doyle, Jefferson J., Dulkerian, Susan J., Dumpa, Vikramaditya, Duncan, Andrea F., Dunham, Alexandra M., Ecret, DiAnn, Ellis, Kelstan, El-Metwally, Dina, Etchill, Eric W., Ethawi, Yahya, Everett, Allen D., Fabres, Jorge, Felling, Ryan J., Fenton, Tanis R., Flannery, Dustin D., Flynn, Joseph T., Fredenburg, Michaelene, Fuqua, John, Garcia, Alejandro V., Garzon, Steven, Gauda, Estelle B., Thompson, Marisa Gilstrop, Goldenberg, Barton, Salazar, Andres J. Gonzalez, Goodwin, Julie E., Goudy, Steven L., Graham, Ernest, Grauerholz, Kathryn, Groves, Mari L., Guillot, Mireille, Gunn, Alistair J., Gupta, Arjun, Hackam, David J., Hidalgo, Joaquin, Honcharuk, Erin, Htun, Zeyar, Hudak, Mark L., Driscoll, Colleen A. Hughes, Huisman, Thierry A.G.M., Jabroun, Mireille, Jackson, Eric M., Jain, Naveen, Jain, Rajesh, Jelin, Angie, Jelin, Eric, Juul, Sandra E., Kaufman, David A., BMBS, Alison Kent, Khuder, Sundos, Kovler, Mark L., Kraus, Courtney L., Krishnamurthy, Ganga, Kukora, Stephanie K., Kumar, Ashok, Kunisaki, Shaun M., Kuper-Sassé, Margaret, Kwiatkowski, David M., Lakshminrusimha, Satyan, Laventhal, Naomi T., Lawrence, Shelley M., Lee-Winn, Angela E., Leuthner, Steven, Lewallen, Laura, Lewis, Tamorah R., Liken, Hillary B., Liubšys, Arūnas, Lui, Kei, Maheshwari, Akhil, Maitre, Nathalie L., Makker, Kartikeya, Mammen, Cherry, J. Martin, Richard, Mattos Castellano, María, Maxwell, Jessie R., McFarlane, Renske, McLemore, Gabrielle, McNelis, Kera M., McPherson, Christopher, Mietzsch, Ulrike, Milante, Rachel R., Miller, Jena L., Mukhopadhyay, Sagori, Mynak, Mimi L., Nasr, Isam W., Natarajan, Niranjana, Navaneethan, Hema, Nees, Shannon N., Nguyen, Mai, Noori, Shahab, Odackal, Namrita J., Ohls, Robin K., Ostrander, Betsy E., Pammi, Mohan, Parimi, Prabhu S., Park, Albert, Patil, Monika S., Pereira, Elaine M., Premkumar, Muralidhar H., Price-Douglas, Webra, Puopolo, Karen M., Rabe, Heike, M. Rahman, Mohammad, Reber, Kristina, Kallem, Venkat Reddy, Repka, Michael X., Rhee, Daniel S., Ringle, Megan L., Rohrer, Allison, Romero, Christopher J., Ryan, Marisa A., Sampah, Maame E.S., Sanchez-Valle, Amarilis, Sant’Anna, Guilherme M., Saugstad, Ola D., RobertH., Anne and, Schacht, John P., Schelonka, Robert L., Schofield, Erin E., Selewski, David T., Shah, Prakesh S., Shih, Jessica G., Sibinga, Erica M.S., Sigal, Winnie, Sims, Brian, Singh, Rachana, Singh, Srijan, Snyder, Donna, Sobrero, Helena, Sponseller, Paul D., Stafstrom, Carl E., Steflik, Heidi J., Sun, Lisa R., Sundararajan, Sripriya, Taylor, Sarah N., Terrin, Norma, Thacker, Prolima G., Thébaud, Bernard, Toms, Rune, Torres, Benjamin A., Tunkel, David E., Umandap, Christine H., Chaves, Diana Vargas, Vento, Maximo, Walsh, Jonathan, Walter, Jolan, Weaver, Meaghann S., Weimer, Kristin, Weller, Jennine, Winter, Lindy W., Wu, Tai-Wei, and Yau, Mabel
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- 2024
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33. Morphological classification and treatment outcomes of children with AML during four years
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environment, Baghdad, Iraq., Ahmed Nadher Kareem, Munaf Authman Hreeth, Iraqi board neonatology, and Sabah Noori Rashid
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Pediatrics ,medicine.medical_specialty ,business.industry ,hemic and lymphatic diseases ,Treatment outcome ,General Engineering ,medicine ,business - Abstract
Acute myeloid leukemia comprises only 15% to 20% of acute leukemia in children. It remains a challenging disease with an inferior treatment outcome in comparison with acute lymphoblastic leukaemia (ALL). This study aimed to document the morphological classification and treatment outcomes of children with Acute Myeloid Leukemia treated in the Child’s Central Teaching Hospital (CCTH) in Baghdad / Iraq. This retrospective study was conducted at CCTH in Baghdad, during the period from 1st January 2009 to 31st December 2012 on 49 cases who were diagnosed as AML. Down syndrome (DS) and acute promyelocytic leukemia (APL), with undifferentiated leukemia were excluded from this study. The average age of presentation was 5 years, and the median duration of symptoms was 4 weeks, with male (M): female (F) ratio = 1.13:1. It can be concluded that there was slight male predominance. The most common French-American-British (FAB) subtype was M2 38.8%. From the total number of patients who received treatment n= 38/49 (77.5%), death rate was n= 27/38 (71%), the main cause of death was infection followed by bleeding, while lost to follow-up (during any period after started treatment) was n= 6/38 (16%). Only five {n= 5/38(13%)} patients were still alive to the end of the study and those are in continuous complete remission one (CCR1). It can be concluded that AML-M2 was the most common subtype, and the overall survival was much low and seems to be unlikely to increase without good supportive care and using of more intensification therapy.
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- 2021
34. TO STUDY THE INCIDENCE OF SENSORINEURAL HEARING LOSS POST MENINGITIS IN NEONATES
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Khursheed Ahmad Wani, Sheikh Quyoom Hussain, Ubaid Ullah Wani, and Neonatology, Skims Soura, Kashmir, India.
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Pediatrics ,medicine.medical_specialty ,business.industry ,Incidence (epidemiology) ,otorhinolaryngologic diseases ,Medicine ,Sensorineural hearing loss ,business ,medicine.disease ,Meningitis - Abstract
Background:Post meningitis hearing impairment is an important public health problem. Neonatal meningitis is an important cause of mortality and morbidity in neonates in future life. An important consequence is hearing loss. Hearing plays a basic and important role in language, speech and intellectual development. Late detection causes irreversible stunting of the language development potential of the child. Early detection and intervention would help to maximize linguistic competence and literacy development for children who are deaf or hard of hearing. The study of brainstem evoked response audiometry provides an opportunity to evaluate the functional integrity of auditory pathway from inner ear to upper brainstem. Aim:This study was conducted to determine the incidence of sensorineural hearing loss following meningitis in neonates. Material and Methods:The present study was conducted in the Department of Pediatrics, Government Medical College Srinagar. All the patients,Term neonates with CSF culture proven bacterial meningitis. , were referred to the Department of ENT, SMHS Hospital Srinagar, of the institution for thorough ENT checkup, to exclude any ear pathology and BERA (Brainstem Evoked Response Audiometry). Results:In our study total number of cases were 87. Majority of our studied children i.e. 47 (54%) were < days of age whereas 40 (46%) children were 8-28 days of aged. The mean age of our study patients was 15.7+3.71.Out of 87 patients in our study, male predominance was observed with 55.2% males versus 44.8% females with a male to female ratio of 1.2:1. Hearing loss was observed in 11 (12.6%) of our study children.Bilateral hearing loss was seen in 5 of the 11 children (5.7%) while as unilateral hearing loss was observed in 6 of the 11 children (6.9%). Out of a total of 11 (12.6%) patients who had hearing loss, 6 (6.9%) were having mild hearing loss, followed by 3 (3.4%) children with profound hearing loss while as moderate and severe hearing loss was observed in 1 (1.1%) patients each. Conclusion: Hearing loss is not a rare complication asociated with meningitis in neonates, early detection and appropriate treatment is needed to prevent language , speech and intellecual damage.
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- 2021
35. Clinical Profile of Children with Beta-Thalassemia
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Aarti A Kinikar, Dilip Kumar, and Junior Consultant, Neonatology, Ovum Women
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Pediatrics ,medicine.medical_specialty ,business.industry ,General Engineering ,medicine ,Beta thalassemia ,medicine.disease ,business - Published
- 2019
36. Weaning Time in Preterm Infants: An Audit of Italian Primary Care Paediatricians
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Maria Elisabetta Baldassarre, Antonio Di Mauro, Annarita Pedico, Valentina Rizzo, Manuela Capozza, Fabio Meneghin, Gianluca Lista, Nicola Laforgia, and on behalf of Italian Society of Pediatrics (SIP), Italian Society of Neonatology (SIN), Italian Society of Pediatric Gastroenterology, Hepatology, and Nutrition (SIGENP) and Italian Federation of Paediatricians (FIMP)
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preterm newborn ,weaning ,primary care ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Introduction: According to the 2016 Italian National Institute of Statistics (Istat) data in Italy, about 6.7% of all newborns are born prematurely. Due to the lack of data on current complementary feeding in preterm infants in Italy, the aim of the survey was to evaluate individual attitudes of primary care paediatricians, concerning the introduction of complementary foods in preterm infants. Methods: An internet-based survey was conducted among primary care paediatricians, working in Italy, regarding (1) timing of the introduction of complementary foods to preterm newborns; (2) type of complementary foods introduced; (3) vitamin D and iron supplementations. Results: A total of 347 primary care Italian paediatricians answered the questionnaire; 44% of responders based the timing of the introduction of solid food exclusively on an infant’s age, 18% on an infant’s neurodevelopmental status and 4% on the body weight; the remaining 34% based the timing on two or more of these aspects. The type of complementary foods did not comply with an evidence-based sequence; 98% of participants promoted vitamin D supplementation and 89% promoted iron supplementation with great diversity in timing and doses. Conclusions: Due to limited evidence, there is a great heterogeneity in the attitudes of primary care paediatricians concerning the introduction of complementary foods to preterm newborns. Further research is needed to provide evidence-based guidelines regarding weaning preterm newborns.
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- 2018
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37. Defining Kawasaki disease and pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection during SARS-CoV-2 epidemic in Italy: results from a national, multicenter survey
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Cattalini M, Della Paolera S, Zunica F, Bracaglia C, Giangreco M, Verdoni L, Meini A, Sottile R, Caorsi R, Zuccotti G, Fabi M, Montin D, Meneghel A, Consolaro A, Dellepiane RM, Maggio MC, La Torre F, Marchesi A, Simonini G, Villani A, Cimaz R, Ravelli A, Taddio A Maria Concetta Alberelli: UOC Pediatria, Marche-Nord, Clotilde Alizzi: Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities 'G. D’Alessandro', University of Palermo, Palermo Italy, Patrizia Barone: Unità Operativa Complessa di Broncopneumologia Pediatrica AOU 'Policlinico - Vittorio Emanuele Via Santa Sofia 78 Catania, Lucia Augusta Baselli: Pediatric Intermediate Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan Italy, Veronica Bennato: U. O. Pediatria, Ospedale A, Manzoni Lecco, Francesca Biscaro: UOC Pediatria, Ospedale Ca’ Foncello, Treviso, Grazia Bossi: UOC Pediatria, Fondazione IRCCS Policlinico San Matteo, Pavia Italy, Andrea Campana: Bambino Gesù Children’s Hospital, Rome Italy, Maurizio Carone: UO Malattie Infettive, Ospedale Pediatrico ‘Giovanni XXIII’, Bari Italy, Adele Civino: U. O. C. Pediatria P. O. Vito Fazzi, Lecce, Giovanni Conti: Nefrologia e Reumatologia Pediatrica con Dialisi, Azienda Ospedaliero-Universitario 'G. Martino', Eleonora Dei Rossi: University of Trieste, Trieste Italy, Emanuela Del Giudice: Department of Maternal Infantile and Urological Sciences, Sapeinza University of Rome, Polo Pontini, Alice Dell’Anna: U. O. C. Pediatria P. O. Vito Fazzi Lecce, Maia De Luca: Bambino Gesù Children’s Hospital, Piazza S. Onofrio n. 4, 00165 Rome, Italy, Enrico Felici: Pediatric and Pediatric Emergency Unit, The Children Hospital, AO SS Antonio e Biago e C. Arrigo, Alessandria Italy, Giovanni Filocamo: Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milano, Ilenia Floretta: Pediatria, Ospedale Santa Chiara, Trento Italy, Maria Loreta Foschini: SC Pediatria, PO SAN MICHELE AOBrotzu, Cagliari Italy, Marcello Lanari: Department of Pediatrics, University of Bologna, IRCCS S. Orsola-Malpighi Hospital, Bologna Italy, Bianca Lattanzi: SOD Pediatria, Ospedali Riuniti, Ancona Italy, Alessandra Lazzerotti: Clinica Pediatrica, Università Milano Bicocca, Fondazione MBBM - onlus c/o Ospedale San Gerardo, Monza Italy, Francesco Licciardi: Department of Pediatrics and Public Health, University of Turin, Turin Italy, Alessandra Manerba: Child Cardiology, ASST Spedali Civili di Brescia and University of Brescia, Brescia Italy, Savina Mannarino: Division of Cardiology, Children’s Hospital V Buzzi, ASST FBF Sacco, Achille Marino: Department of Pediatrics, Desio Hospital, ASST Monza, Desio Italy, Agostina Marolda: Pediatrics and Neonatology Dipartment, ASST Ovest Milanese, 'G. Fornaroli' Hospital, Magenta Milan, Laura Martelli: Paediatric Department, Hospital Papa Giovanni XXIII, Bergamo Italy, Giorgia Martini, Department of Woman’s and Child’s Health, University of Padova, Padua Italy, Angela Mauro: Department of Paediatrics, Emergency Department, Santobono-Pausilipon Children’s Hospital, Naples, Italy. Maria Vincenza Mastrolia: Pediatric Rheumatology Unit, AOU Meyer, University of Florence, Florence, Italy. Angelo Mazza: Paediatric Department, Angela Miniaci: Clinica Pediatrica, Reumatologia, Azienda Ospedaliero-Universitaria di Bologna, Francesca Minoia: Fondazione IRCCS Cà Granda, Alma Olivieri: Dipartimento della donna, del bambino e di chirurgia generale e specialistica, Università della Campania, 'L Vanvitelli, Napoli, Guido Pennoni: Dipartimento Materno-Infantile, Gubbio-Gualdo Tadino, Italy, Rossana Pignataro: UOC Pediatria e Neonatologia, ASST Lodi, Lodi, Francesca Ricci, Clinica Pediatrica, ASST Spedali Civili di Brescia e Università degli Studi di Brescia, Donato Rigante: Department of Pediatrics, Univarsità Cattolica Sacro Cuore, Matilde Rossi: UOC di Pediatrai e Neonatologia, Ospedale di Macerata, Macerata, Claudia Santagati: Dipartimento di Pediatria, Ospedale di Rovigo, Rovigo, Martina Soliani: Pediatria ASST Cremona, Italy, Silvia Sonego: University of Trieste, Domenico Sperlì: UOC di Pediatria, S. O. 'Annunziata' - A. O. di Cosenza, Sara Stucchi: Maternal and Child Health, Division of Paediatrics, ASST Grande Ospedale Metropolitano Niguarda, Milano Italy, Barbara Teruzzi: Maternal and Child Health, Elpidio Tierno: UOC di Pediatria, Dipartimento della Salute della Donna e del Bambin, AORN 'Sant’Anna e San Sebastiano'- Caserta, Tatiana Utytatnikova: Dipartimento Materno-Infantile, Pediatria, ASST Bergamo-EST, Seriate Bergamo, Piero Valentini, Department of Pediatrics, Gianluca Vergine, UOC Pediatria Rimini, Ospedale Infermi, ASL Romagna, Rimini Italy., Cattalini, Marco, Della Paolera, Sara, Zunica, Fiammetta, Bracaglia, Claudia, Giangreco, Manuela, Verdoni, Lucio, Meini, Antonella, Sottile, Rita, Caorsi, Roberta, Zuccotti, Gianvincenzo, Fabi, Marianna, Montin, Davide, Meneghel, Alessandra, Consolaro, Alessandro, Dellepiane, Rosa Maria, Maggio, Maria Cristina, La Torre, Francesco, Marchesi, Alessandra, Simonini, Gabriele, Villani, Alberto, Cimaz, Rolando, Ravelli, Angelo, Taddio, Andrea, Cattalini, M, Della Paolera, S, Zunica, F, Bracaglia, C, Giangreco, M, Verdoni, L, Meini, A, Sottile, R, Caorsi, R, Zuccotti, G, Fabi, M, Montin, D, Meneghel, A, Consolaro, A, Dellepiane, Rm, Maggio, Mc, La Torre, F, Marchesi, A, Simonini, G, Villani, A, Cimaz, R, Ravelli, A, Taddio, A Maria Concetta Alberelli: UOC Pediatria, Marche-Nord, Clotilde Alizzi: Department of Health Promotion Sciences Maternal and Infantile, Care, Internal Medicine and Medical Specialities 'G., D’Alessandro', University of, Palermo, Palermo, Italy, Patrizia Barone: Unità Operativa Complessa di Broncopneumologia Pediatrica AOU 'Policlinico, - Vittorio Emanuele Via Santa Sofia 78 Catania, Lucia Augusta Baselli: Pediatric Intermediate Care, Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore, Policlinico, Milan, Italy, Veronica Bennato: U. O., Pediatria, Ospedale, A, Manzoni, Lecco, Francesca Biscaro: UOC, Pediatria, Ospedale Ca’, Foncello, Treviso, Grazia Bossi: UOC, Pediatria, Fondazione IRCCS Policlinico San, Matteo, Pavia, Italy, Andrea Campana: Bambino Gesù Children’s, Hospital, Rome, Italy, Maurizio Carone: UO Malattie, Infettive, Ospedale Pediatrico ‘Giovanni, Xxiii’, Bari, Italy, Adele Civino: U. O. C. Pediatria P. O. Vito Fazzi, Lecce, Giovanni Conti: Nefrologia e Reumatologia Pediatrica con Dialisi, Azienda Ospedaliero-Universitario 'G. Martino', Eleonora Dei Rossi: University of, Trieste, Trieste, Italy, Emanuela Del Giudice: Department of Maternal Infantile and Urological, Science, Sapeinza University of, Rome, Polo, Pontini, Alice Dell’Anna: U. O. C. Pediatria P. O., Vito Fazzi Lecce, Maia De Luca: Bambino Gesù Children’s, Hospital, Piazza, S. Onofrio n. 4., 00165, Rome, Italy, Enrico Felici: Pediatric and Pediatric Emergency, Unit, The Children, Hospital, AO SS Antonio e Biago e C., Arrigo, Alessandria, Italy, Giovanni Filocamo: Fondazione IRCCS Cà, Granda, Ospedale Maggiore, Policlinico, Milano, Ilenia Floretta:, Pediatria, Ospedale Santa, Chiara, Trento, Italy, Maria Loreta Foschini: SC, Pediatria, PO SAN MICHELE, Aobrotzu, Cagliari, Italy, Marcello Lanari: Department of, Pediatric, University of, Bologna, IRCCS S., Orsola-Malpighi Hospital, Bologna, Italy, Bianca Lattanzi: SOD, Pediatria, Ospedali, Riuniti, Ancona, Italy, Alessandra Lazzerotti: Clinica, Pediatrica, Università Milano, Bicocca, Fondazione MBBM, - onlus c/o Ospedale San Gerardo, Monza, Italy, Francesco Licciardi: Department of Pediatrics and Public, Health, University of, Turin, Turin, Italy, Alessandra Manerba: Child, Cardiology, ASST Spedali Civili di Brescia and University of, Brescia, Brescia, Italy, Savina Mannarino: Division of, Cardiology, Children’s Hospital, V Buzzi, ASST FBF, Sacco, Achille Marino: Department of, Pediatric, Desio, Hospital, Asst, Monza, Desio, Italy, Agostina Marolda: Pediatrics and Neonatology, Dipartment, ASST Ovest, Milanese, 'G., Fornaroli' Hospital, Magenta, Milan, Laura Martelli: Paediatric, Department, Hospital Papa Giovanni, Xxiii, Bergamo, Italy, Giorgia, Martini, Department of Woman’s and Child’s, Health, University of, Padova, Padua, Italy, Angela Mauro: Department of, Paediatric, Emergency, Department, Santobono-Pausilipon Children’s, Hospital, Naples, Italy., Maria Vincenza Mastrolia: Pediatric Rheumatology Unit, Aou, Meyer, University of, Florence, Florence, Italy., Angelo Mazza: Paediatric Department, Angela Miniaci: Clinica, Pediatrica, Reumatologia, Azienda Ospedaliero-Universitaria di, Bologna, Francesca Minoia: Fondazione IRCCS Cà, Granda, Alma Olivieri: Dipartimento della, Donna, del bambino e di chirurgia generale, e specialistica, Università della, Campania, 'L, Vanvitelli, Napoli, Claudio, Guido Pennoni: Dipartimento, Materno-Infantile, Gubbio-Gualdo Tadino, Italy, Rossana Pignataro: UOC Pediatria, e Neonatologia, Asst, Lodi, Lodi, Francesca, Ricci, Clinica, Pediatrica, ASST Spedali Civili di Brescia, e Università degli Studi di Brescia, Donato Rigante: Department of, Pediatric, Univarsità Cattolica Sacro, Cuore, Matilde Rossi: UOC di Pediatrai, e Neonatologia, Ospedale di, Macerata, Macerata, Claudia Santagati: Dipartimento di, Pediatria, Ospedale di, Rovigo, Rovigo, Martina Soliani: Pediatria ASST Cremona, Italy, Silvia Sonego: University of, Trieste, Domenico Sperlì: UOC di Pediatria, S. O. 'Annunziata' - A. O. di Cosenza, Sara Stucchi: Maternal and Child, Health, Division of, Paediatric, ASST Grande Ospedale Metropolitano, Niguarda, Milano, Italy, Barbara Teruzzi: Maternal and Child, Health, Elpidio Tierno: UOC di, Pediatria, Dipartimento della Salute della Donna, e del Bambin, AORN 'Sant’Anna, e San Sebastiano'- Caserta, Tatiana Utytatnikova: Dipartimento, Materno-Infantile, Pediatria, Asst, Bergamo-EST, Seriate, Bergamo, Piero, Valentini, Department of, Pediatric, Gianluca, Vergine, UOC Pediatria, Rimini, Ospedale, Infermi, Asl, Romagna, Rimini, Italy., Cattalini M., Della Paolera S., Zunica F., Bracaglia C., Giangreco M., Verdoni L., Meini A., Sottile R., Caorsi R., Zuccotti G., Fabi M., Montin D., Meneghel A., Consolaro A., Dellepiane R.M., Maggio M.C., La Torre F., Marchesi A., Simonini G., Villani A., Cimaz R., Ravelli A., Taddio A., Adamoli P., Alberelli M.C., Alizzi C., Barone P., Bennato V., Biscaro F., Bossi G., Campana A., Carone M., Civino A., Conti G., Rossi E.D., Del Giudice E., Dell'Anna A., De Luca M., Felici E., Filocamo G., Floretta I., Foschini M.L., Lanari M., Lattanzi B., Lazzerotti A., Licciardi F., Manerba A., Mannarino S., Marino A., Marolda A., Martelli L., Martini G., Mauro A., Mastrolia M.V., Mazza A., Miniaci A., Minoia F., Olivieri A., Pennoni G., Pignataro R., Ricci F., Rigante D., Rossi M., Santagati C., Soliani M., Sonego S., Sperli D., Stucchi S., Teruzzi B., Tierno E., Utytatnikova T., Valentini P., and Vergine G.
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Coronary artery abnormalities ,Hypotension ,Kawasaki disease ,Multisystem inflammatory syndrome associated with coronavirus disease ,Myocarditis ,Pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection ,SARS-CoV-2 ,Age Distribution ,Antirheumatic Agents ,Aspirin ,C-Reactive Protein ,COVID-19 ,Child ,Child, Preschool ,Coronary Artery Disease ,Cough ,Diarrhea ,Dyspnea ,Female ,Glucocorticoids ,Heart Failure ,Humans ,Hyperferritinemia ,Immunoglobulins, Intravenous ,Immunologic Factors ,Infant ,Intensive Care Units, Pediatric ,Interleukin 1 Receptor Antagonist Protein ,Italy ,Lymphopenia ,Male ,Mucocutaneous Lymph Node Syndrome ,Platelet Aggregation Inhibitors ,Shock ,Systemic Inflammatory Response Syndrome ,Tachypnea ,Troponin T ,Vomiting ,lcsh:Diseases of the musculoskeletal system ,coronary artery abnormalities ,hypotension ,kawasaki disease ,multisystem inflammatory syndrome associated with coronavirus disease ,myocarditis ,pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection ,age distribution ,antirheumatic agents ,aspirin ,C-reactive protein ,child ,preschool ,coronary artery disease ,cough ,diarrhea ,yspnea ,female ,glucocorticoids ,heart failure ,humans ,hyperferritinemia ,immunoglobulins ,intravenous ,immunologic factors ,infant ,intensive care units ,pediatric ,interleukin 1 receptor antagonist protein ,italy ,lymphopenia ,male ,mucocutaneous lymph node syndrome ,platelet aggregation inhibitors ,shock ,systemic inflammatory response syndrome ,tachypnea ,troponin T ,vomiting ,Myocarditi ,030204 cardiovascular system & hematology ,SARS-CoV-2, Kawasaki disease, Pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection, Myocarditis, Hypotension, Multisystem inflammatory syndrome associated with coronavirus disease, Coronary artery abnormalities ,Coronary artery disease ,Settore MED/38 - Pediatria Generale E Specialistica ,0302 clinical medicine ,Glucocorticoid ,Immunologic Factor ,Immunology and Allergy ,Coronary artery abnormalitie ,Fisher's exact test ,Pediatric ,biology ,lcsh:RJ1-570 ,Antirheumatic Agent ,Settore MED/38 ,Intensive Care Units ,Cohort ,symbols ,Platelet aggregation inhibitor ,Intravenous ,Human ,Research Article ,medicine.medical_specialty ,Immunoglobulins ,03 medical and health sciences ,symbols.namesake ,Rheumatology ,Internal medicine ,medicine ,Preschool ,030203 arthritis & rheumatology ,business.industry ,Platelet Aggregation Inhibitor ,lcsh:Pediatrics ,medicine.disease ,Systemic inflammatory response syndrome ,Immunoglobulins, Intravenou ,Pediatrics, Perinatology and Child Health ,biology.protein ,lcsh:RC925-935 ,business - Abstract
Background There is mounting evidence on the existence of a Pediatric Inflammatory Multisystem Syndrome-temporally associated to SARS-CoV-2 infection (PIMS-TS), sharing similarities with Kawasaki Disease (KD). The main outcome of the study were to better characterize the clinical features and the treatment response of PIMS-TS and to explore its relationship with KD determining whether KD and PIMS are two distinct entities. Methods The Rheumatology Study Group of the Italian Pediatric Society launched a survey to enroll patients diagnosed with KD (Kawasaki Disease Group – KDG) or KD-like (Kawacovid Group - KCG) disease between February 1st 2020, and May 31st 2020. Demographic, clinical, laboratory data, treatment information, and patients’ outcome were collected in an online anonymized database (RedCAP®). Relationship between clinical presentation and SARS-CoV-2 infection was also taken into account. Moreover, clinical characteristics of KDG during SARS-CoV-2 epidemic (KDG-CoV2) were compared to Kawasaki Disease patients (KDG-Historical) seen in three different Italian tertiary pediatric hospitals (Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, Trieste; AOU Meyer, Florence; IRCCS Istituto Giannina Gaslini, Genoa) from January 1st 2000 to December 31st 2019. Chi square test or exact Fisher test and non-parametric Wilcoxon Mann-Whitney test were used to study differences between two groups. Results One-hundred-forty-nine cases were enrolled, (96 KDG and 53 KCG). KCG children were significantly older and presented more frequently from gastrointestinal and respiratory involvement. Cardiac involvement was more common in KCG, with 60,4% of patients with myocarditis. 37,8% of patients among KCG presented hypotension/non-cardiogenic shock. Coronary artery abnormalities (CAA) were more common in the KDG. The risk of ICU admission were higher in KCG. Lymphopenia, higher CRP levels, elevated ferritin and troponin-T characterized KCG. KDG received more frequently immunoglobulins (IVIG) and acetylsalicylic acid (ASA) (81,3% vs 66%; p = 0.04 and 71,9% vs 43,4%; p = 0.001 respectively) as KCG more often received glucocorticoids (56,6% vs 14,6%; p Conclusion Our study suggests that SARS-CoV-2 infection might determine two distinct inflammatory diseases in children: KD and PIMS-TS. Older age at onset and clinical peculiarities like the occurrence of myocarditis characterize this multi-inflammatory syndrome. Our patients had an optimal response to treatments and a good outcome, with few complications and no deaths.
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- 2020
38. Antenatal hydronephrosis: a five-year retrospective study
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Margarida Peixoto, Mariana Capela, Centro Hospitalar de Vila Nova de Gaia Neonatology, Joana Borges, Graça Ferreira, Espinho, Vila Nova de Gaia, Portugal, and Maria Gaia
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medicine.medical_specialty ,Obstetrics ,business.industry ,medicine ,Antenatal Hydronephrosis ,Retrospective cohort study ,business - Abstract
Introduction: Antenatal hydronephrosis (ANH) is common in fetal ultrasounds. Though mostly transient, it can be associated with congenital abnormalities and kidney injury. The authors went to assess the evolution of children with ANH and identify risk groups. Methods: Retrospective cohort study of children with ANH from 2013‑2017. Renal pelvis anteroposterior diameter (APD) of 4 and 7mm or more in the second and third trimester, respectively, defined diagnosis of ANH. APD also defined severity stratification. The primary out‑ comes included occurrence of urinary tract infection (UTI) and congenital anomalies of the kidney and urinary tract (CAKUT). Results: We identified 198 cases, with male predominance (76.8%) and a 2.1% incidence. It resolved antenatally in 12.1%, with a lower mean value of APD in these cases (p=0.017), and persisted in 43.4%. CAKUT were found in 8.6% of the patients. At least 1 episode of UTI occurred in 9.1% of patients during follow‑up. The degree of ANH in the 3rd trimester was related to postnatal persistence and degree (p
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- 2021
39. Contributors
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Backes, Carl, Bhombal, Shazia, Bischoff, Adrianne Rahde, Blank, Douglas A., Boly, TJ, Boyd, Stephanie M., Bussmann, Neidin, Chatmethakul, Trassanee, Cox, David J., de Boode, Willem-Pieter, de Waal, Koert, Dempsey, Eugene, Dix, Laura, du Plessis, Adre J., El-Khuffash, Afif Faisal, Eriksen, Beate Horsberg, Evans, Nicholas, Fernandez, Erika F., Fisher, Elizabeth Rachel, Fugelseth, Drude, Giesinger (E), Regan, Greisen, Gorm, Groves, Alan M., Gupta, Samir, Hébert, Audrey, Hooper, Stuart B., Jain, Amish, Katheria, Anup C., Kluckow, Martin, Krishnamurthy, Ganga, Van Laere, David, Lakshminrusimha, Satyan, Lemmers, Petra, Levy, Philip T., McNamara, Patrick J., McPherson, Christopher, Mitra, Souvik, Nijres, Bassel Mohammad, Mulkey, Sarah B., Nagpal, Rema S., Naulaers, Gunnar, Neary, Elaine, Nestaas, Eirik, Noori, Shahab, Price, Anthony N., Pruetz, Jay D., Rios, Danielle R., Sahni, Mohit, Schlatterer, Sarah D., Seri, Istvan, Shah, Prakesh S., Singh, Yogen, Victor, Suresh, Suryawanshi, Pradeep, van Bel, Frank, Vasquez, Angelica, Weindling, Michael, and Weisz, Dany E.
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- 2024
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40. Study of efficacy and safety of levosalbutamol versus racemic salbutamol delivered by metered dose inhaler in children with moderate persistent asthma
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Neonatology, Pgimer, Chandigarh, India., Joseph L. Mathew, Meenu Singh, and Sarita Sharma
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Levosalbutamol ,business.industry ,Anesthesia ,Salbutamol ,medicine ,Persistent asthma ,business ,Metered-dose inhaler ,medicine.drug - Published
- 2019
41. Probiotics Prevent Late-Onset Sepsis in Human Milk-Fed, Very Low Birth Weight Preterm Infants: Systematic Review and Meta-Analysis
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Arianna Aceti, Luca Maggio, Isadora Beghetti, Davide Gori, Giovanni Barone, Maria Luisa Callegari, Maria Pia Fantini, Flavia Indrio, Fabio Meneghin, Lorenzo Morelli, Gianvincenzo Zuccotti, Luigi Corvaglia, and on behalf of the Italian Society of Neonatology.
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late-onset sepsis ,probiotic ,preterm infants ,human milk ,meta-analysis ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Growing evidence supports the role of probiotics in reducing the risk of necrotizing enterocolitis, time to achieve full enteral feeding, and late-onset sepsis (LOS) in preterm infants. As reported for several neonatal clinical outcomes, recent data have suggested that nutrition might affect probiotics’ efficacy. Nevertheless, the currently available literature does not explore the relationship between LOS prevention and type of feeding in preterm infants receiving probiotics. Thus, the aim of this systematic review and meta-analysis was to evaluate the effect of probiotics for LOS prevention in preterm infants according to type of feeding (exclusive human milk (HM) vs. exclusive formula or mixed feeding). Randomized-controlled trials involving preterm infants receiving probiotics and reporting on LOS were included in the systematic review. Only trials reporting on outcome according to feeding type were included in the meta-analysis. Fixed-effects models were used and random-effects models were used when significant heterogeneity was found. The results were expressed as risk ratio (RR) with 95% confidence interval (CI). Twenty-five studies were included in the meta-analysis. Overall, probiotic supplementation resulted in a significantly lower incidence of LOS (RR 0.79 (95% CI 0.71–0.88), p < 0.0001). According to feeding type, the beneficial effect of probiotics was confirmed only in exclusively HM-fed preterm infants (RR 0.75 (95% CI 0.65–0.86), p < 0.0001). Among HM-fed infants, only probiotic mixtures, and not single-strain products, were effective in reducing LOS incidence (RR 0.68 (95% CI 0.57–0.80) p < 0.00001). The results of the present meta-analysis show that probiotics reduce LOS incidence in exclusively HM-fed preterm infants. Further efforts are required to clarify the relationship between probiotics supplementation, HM, and feeding practices in preterm infants.
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- 2017
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42. Case 3: Apnea in Preterm Neonates
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Dnb (Neonatology), Obeid M. Shafi, Navin Kumar, Pradeep Kumar, Ashok Saxena, and Vinay Kumar Rai
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Vaginal delivery ,business.industry ,Apnea ,medicine.medical_treatment ,Infant, Newborn ,medicine.disease ,Sepsis ,03 medical and health sciences ,0302 clinical medicine ,Intraventricular hemorrhage ,030225 pediatrics ,Neonatal Resuscitation Program ,Anesthesia ,Pediatrics, Perinatology and Child Health ,medicine ,Rupture of membranes ,Humans ,030212 general & internal medicine ,Continuous positive airway pressure ,medicine.symptom ,business ,Premature rupture of membranes ,Infant, Premature - Abstract
Case Presentation A 27-week-gestation female neonate is born via vaginal delivery, with a birthweight of 720 g, to a gravida 2, para 1 woman. The mother comes to the emergency department with evidence of preterm premature rupture of membranes. Her total leukocyte count is 17,250/μL (17.25×109/L), with a polymorphonuclear lymphocyte count of 84%, and C-reactive protein (CRP) value is 1.85 mg/dL (18.5 mg/L; reference range
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- 2021
43. Management of oxygen saturation monitoring in preterm newborns in the NICU: the Italian picture
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Child Health, MS Neonatologie, Brain, National Study Group of Neonatal Clinical Biochemistry of the Italian Society of Neonatology, Child Health, MS Neonatologie, Brain, and National Study Group of Neonatal Clinical Biochemistry of the Italian Society of Neonatology
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- 2021
44. Adherence to hypothermia guidelines: a French multicenter study of fullterm neonates.
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Marie Chevallier, Anne Ego, Christine Cans, Thierry Debillon, and French Society of Neonatology
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Medicine ,Science - Abstract
The objective of this study was to describe the French practice of hypothermia treatment (HT) in full-term newborns with hypoxic-ischemic encephalopathy (HIE) and to analyze the deviations from the guidelines of the French Society of Neonatology.From May 2010 to March 2012 we recorded all cases of HIE treated by HT in a French national database. The population was divided into three groups, "optimal HT" (OHT), "late HT" (LHT) and "non-indicated" HT (NIHT), according to the guidelines.Of the 311 newborns registered in the database and having HT, 65% were classified in the OHT group, 22% and 13% in the LHT and NIHT groups respectively. The severity of asphyxia and HIE were comparable between newborns with OHT and LHT, apart from EEG. HT was initiated at a mean time of 12 hours of life in the LHT group. An acute obstetrical event was more likely to be identified among newborns with LHT (46%), compared to OHT (34%) and NIHT (22%). There was a gradation in the rate of complications from the NIHT group (29%) to the LHT (38%) group and the OHT group (52%). Despite an insignificant difference in the rates of death or abnormal neurological examination at discharge, nearly 60% of newborns in the OHT group had an MRI showing abnormalities, compared to 44% and 49% in the LHT and NIHT groups respectively.The conduct of the HT for HIE newborns is not consistent with French guidelines for 35% of newborns, 22% being explained by an excessive delay in the start of HT, 13% by the lack of adherence to the clinical indications. This first report illustrates the difficulties in implementing guidelines for HT and should argue for an optimization of perinatal care for HIE.
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- 2013
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45. Case 3: Apnea in Preterm Neonates
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Rai, Vinay Kumar, primary, (Neonatology), DNB, additional, Saxena, Ashok, additional, Kumar, Navin, additional, Shafi, Obeid M., additional, and Kumar, Pramod, additional
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- 2021
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46. Study of Clinical and Biochemical Profile in Neonatal Seizure in a tertiary care centre of Jharkhand
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Neonatology, Rims, Ranchi, India and Dilip Kumar
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Pediatrics ,medicine.medical_specialty ,business.industry ,Medicine ,business ,Neonatal seizure ,Tertiary care - Published
- 2020
47. Henoch-Schönlein Purpura: What to expect
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Graça Ferreira, Joana Borges, Espinho, Centro Hospitalar de Vila Nova de Gaia Neonatology, Eduarda Marques, Maria Gaia, Portugal, Mariana Capela, and António V. Silva
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medicine.medical_specialty ,Henoch-Schonlein purpura ,business.industry ,medicine ,business ,medicine.disease ,Dermatology - Published
- 2020
48. EPILEPSY IN CHILD, PARTICULARITIES RELATED TO EVOLUTION AND PROGNOSIS – A CASE REPORT AND A REVIEW OF THE LITERATURE
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Tirgu Mures Pharmacy, Lorena Elena Melit, Cristina Oana Mărginean, Raluca Damian, Maria Oana Mărginean, Andreea Dincă, Tirgu Mures Neonatology Clinic, and Nicoleta Suciu
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child ,medicine.medical_specialty ,business.industry ,General Medicine ,medicine.disease ,Pediatrics ,RJ1-570 ,Epilepsy ,evolution ,medicine ,epilepsy ,Medicine ,prognosis ,business ,Psychiatry - Abstract
Epilepsy is a brain pathology that consists in the development of recurrent epileptic seizures, and more than half of the cases present the onset during childhood. We present the case of a 3-year-old male patient, with heredocollateral antecedents of epilepsy and personal history of neuropsychomotor retardation, who was admitted in our clinic presenting generalized tonic clonic seizures, initially febrile and afterwards afebrile. The laboratory tests and the neuroimagistic ones did not identify an underlying cause. The initial EEG did not point out anything pathological. Despite the anticonvulsant treatment, the patient’s evolution was unfavorable, presenting multiple short term recurrences, being readmitted multiple times in our clinic. Once we introduced the second anticonvulsant drug, levetiracetam, in his treatment, the seizures disappeared, and the patient presented long term favorable evolution. The case particularity consists in the development of generalized tonic clonic seizures in a patient with significant family history, and personal history of neuropsychomotor retardation that appear initial under febrile context, and afterwards in the lack of fever, repeating cyclic, with unfavorable evolution despite the treatment with valproic acid that disappear only after initiating treatment with levetiracetam.
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- 2017
49. PROTEIN-LOSING ENTEROPATHY AFTER INFECTIOUS ENTEROCOLITIS IN CHILD – A CASE REPORT AND A REVIEW OF THE LITERATURE
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Cristian Dan Mărginean, Cristina Oana Mărginean, Tg. Mures Neonatology Clinic, Tg. Mures Pharmacy, Raluca Damian, Lorena Elena Melit, and Andreea Dincă
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medicine.medical_specialty ,child ,business.industry ,enterocolitis ,Protein losing enteropathy ,General Engineering ,Infectious and parasitic diseases ,RC109-216 ,escherichia coli enteropathogenic ,medicine.disease ,Infectious Enterocolitis ,Gastroenterology ,Internal medicine ,medicine ,General Earth and Planetary Sciences ,Medicine ,protein-losing enteropathy ,business ,General Environmental Science - Abstract
Protein-losing enteropathy (PLE) represents an abnormal protein loss at the level of the digestive tract mucosa, being in most of the cases secondary to other gastrointestinal or extraintestinal pathologies. Nevertheless, there also are primary causes, genetic ones associated with PLE. We present the case of a small female child, 1 year and 1 month-old, with a history of infectious enterocolitis determined by Escherichia coli enteropathogenic, who presented palpebral edemas, especially in the morning for approximately 1 week. The laboratory tests revealed hypoalbuminemia, type A and G hypogammaglobulinemia, leukocytosis with eosinophilia, and anemia. The test for the detection of occult hemorrhages from feces was positive, likewise the fecal calprotectin and level of alpha-1 antitrypsin. We identified also allergy to cow’s milk protein, which we interpreted as being secondary to the intestinal pathology. Thus, we established the diagnosis of protein losing enteropathy after an episode of acute enterocolitis caused by E. coli enteropathogenic, and we administered substitutive treatment with human albumin and steroids, with favorable evolution. The particularity of the case consists in diagnosing a severe case of protein-losing enteropathy in a small child, with palpebral edema, predominantly during the morning, and decreased levels of serum albumin, after an episode of acute enterocolitis caused by E. coli enteropathogenic, which remitted without etiologic treatment.
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- 2017
50. Surveying family access: kangaroo mother care and breastfeeding policies across NICUs in Italy.
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Artese, Claudia, Ferrari, Fabrizio, Perugi, Silvia, Cavicchioli, Paola, Paterlini, Giuseppe, Mosca, Fabio, the Developmental Care Study Group of Italian Society and Neonatology, Bertoncelli, Natascia, Chiandotto, Valeria, Strola, Paterizia, Simeoni, Natascia, Calciolari, Guido, Colombo, Grazia, Rovei, Serena, Arenga, Immacolata, Arpi, Elena, and Montirosso, Rosario
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HEALTH policy ,NEONATAL intensive care ,HEALTH services accessibility ,ACQUISITION of data methodology ,NEONATAL intensive care units ,SURVEYS ,DOCUMENTATION ,BREASTFEEDING ,QUESTIONNAIRES ,MEDICAL records ,POSTNATAL care ,PARENTS - Abstract
Background: Studies on the application of developmental care initiatives in Italian NICUs are rather scarce. We aimed to assess parental access to the NICUs and facilities offered to the family members and to test "the state of art" regarding kangaroo mother care (KMC) and breastfeeding policies in level III Italian NICUs. Methods: A questionnaire both in paper and in electronic format was sent to all 106 Italian level III NICUs; 86 NICUs (i.e., 80% of NICUs) were completed and returned. The collected data were analysed. In addition, a comparison between the 2017 survey results and those of two previous surveys conducted from 2001 to 2006 was performed. Results: In total, 53 NICUs (62%) reported 24-h open access for both parents (vs. 35% in 2001 and 32% in 2006). Parents were requested to temporarily leave the unit during shift changes, emergencies and medical rounds in 55 NICUs (64%). Some parental amenities, such as an armchair next to the crib (81 units (94%)), a room for pumping milk and a waiting room, were common, but others, such as family rooms (19 units (22%)) and adjoining accommodation (30 units (35%)), were not. KMC was practised in 81 (94%) units, but in 72 (62%), i.e., the majority of units, KMC was limited to specific times. In 11 (13%) NICUs, KMC was not offered to the father. The average duration of a KMC session, based on unit staff estimation, was longer in 24-h access NICUs than in limited-access NICUs. KMC documentation in medical records was reported in only 59% of questionnaires. Breastfeeding was successful in a small proportion of preterm infants staying in the NICU. Conclusion: The number of 24-h access NICUs doubled over a period of 13 years. Some basic family facilities, such as a dedicated kitchen, rooms with dedicated beds and showers for the parents, remain uncommon. KMC and breastfeeding have become routine practices; however, the frequency and duration of KMC sessions reported by NICU professionals still do not meet the WHO recommendations. [ABSTRACT FROM AUTHOR]
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- 2021
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