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144 results on '"Nemtsova Marina"'

1. CDKN2A Gene Mutations: Implications for Hereditary Cancer Syndromes

Author

Danishevich, Anastasiia, primary, Bilyalov, Airat, additional, Nikolaev, Sergey, additional, Khalikov, Nodirbec, additional, Isaeva, Daria, additional, Levina, Yuliya, additional, Makarova, Maria, additional, Nemtsova, Marina, additional, Chernevskiy, Denis, additional, Sagaydak, Olesya, additional, Baranova, Elena, additional, Vorontsova, Maria, additional, Byakhova, Mariya, additional, Semenova, Anna, additional, Galkin, Vsevolod, additional, Khatkov, Igor, additional, Gadzhieva, Saida, additional, and Bodunova, Natalia, additional

Published
2023
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2. Epigenomic Profiling Advises Therapeutic Potential of Leukotriene Receptor Inhibitors for a Subset of Triple-Negative Breast Tumors

Author

Kalinkin, Alexey I., primary, Sigin, Vladimir O., additional, Kuznetsova, Ekaterina B., additional, Ignatova, Ekaterina O., additional, Vinogradov, Ilya I., additional, Vinogradov, Maxim I., additional, Vinogradov, Igor Y., additional, Zaletaev, Dmitry V., additional, Nemtsova, Marina V., additional, Kutsev, Sergey I., additional, Tanas, Alexander S., additional, and Strelnikov, Vladimir V., additional

Published
2023
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5. MiRNA-21a, miRNA-145, and miRNA-221 Expression and Their Correlations with WNT Proteins in Patients with Obstructive and Non-Obstructive Coronary Artery Disease.

Author

Iusupova, Alfiya Oskarovna, Pakhtusov, Nikolay Nikolaevich, Slepova, Olga Alexandrovna, Belenkov, Yuri Nikitich, Privalova, Elena Vitalievna, Bure, Irina Vladimirovna, Vetchinkina, Ekaterina Alexandrovna, and Nemtsova, Marina Vyacheslavovna

Subjects
CORONARY artery disease, WNT signal transduction, DISEASE risk factors, CORONARY arteries, MICRORNA
Abstract

MicroRNAs and the WNT signaling cascade regulate the pathogenetic mechanisms of atherosclerotic coronary artery disease (CAD) development. Objective: To evaluate the expression of microRNAs (miR-21a, miR-145, and miR-221) and the role of the WNT signaling cascade (WNT1, WNT3a, WNT4, and WNT5a) in obstructive CAD and ischemia with no obstructive coronary arteries (INOCA). Method: The cross-sectional observational study comprised 94 subjects. The expression of miR-21a, miR-145, miR-221 (RT-PCR) and the protein levels of WNT1, WNT3a, WNT4, WNT5a, LRP6, and SIRT1 (ELISA) were estimated in the plasma of 20 patients with INOCA (66.5 [62.8; 71.2] years; 25% men), 44 patients with obstructive CAD (64.0 [56.5; 71,0] years; 63.6% men), and 30 healthy volunteers without risk factors for cardiovascular diseases (CVD). Results: Higher levels of WNT1 (0.189 [0.184; 0.193] ng/mL vs. 0.15 [0.15–0.16] ng/mL, p < 0.001) and WNT3a (0.227 [0.181; 0.252] vs. 0.115 [0.07; 0.16] p < 0.001) were found in plasma samples from patients with obstructive CAD, whereas the INOCA group was characterized by higher concentrations of WNT4 (0.345 [0.278; 0.492] ng/mL vs. 0.203 [0.112; 0.378] ng/mL, p = 0.025) and WNT5a (0.17 [0.16; 0.17] ng/mL vs. 0.01 [0.007; 0.018] ng/mL, p < 0.001). MiR-221 expression level was higher in all CAD groups compared to the control group (p < 0.001), whereas miR-21a was more highly expressed in the control group than in the obstructive (p = 0.012) and INOCA (p = 0.003) groups. Correlation analysis revealed associations of miR-21a expression with WNT1 (r = −0.32; p = 0.028) and SIRT1 (r = 0.399; p = 0.005) protein levels in all CAD groups. A positive correlation between miR-145 expression and the WNT4 protein level was observed in patients with obstructive CAD (r = 0.436; p = 0.016). Based on multivariate regression analysis, a mathematical model was constructed that predicts the type of coronary lesion. WNT3a and LRP6 were the independent predictors of INOCA (p < 0.001 and p = 0.002, respectively). Conclusions: Activation of the canonical cascade of WNT-β-catenin prevailed in patients with obstructive CAD, whereas in the INOCA and control groups, the activity of the non-canonical pathway was higher. It can be assumed that miR-21a has a negative effect on the formation of atherosclerotic CAD. Alternatively, miR-145 could be involved in the development of coronary artery obstruction, presumably through the regulation of the WNT4 protein. A mathematical model with WNT3a and LRP6 as predictors allows for the prediction of the type of coronary artery lesion. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Chromosomal Instability in Gastric Cancer: Role in Tumor Development, Progression, and Therapy.

Author

Nemtsova, Marina V., Kuznetsova, Ekaterina B., and Bure, Irina V.

Subjects
*STOMACH cancer, *CHROMOSOMAL rearrangement, *ADJUVANT chemotherapy, *TUMORS, *LOCUS (Genetics)
Abstract

According to the Cancer Genome Atlas (TCGA), gastric cancers are classified into four molecular subtypes: Epstein–Barr virus-positive (EBV+), tumors with microsatellite instability (MSI), tumors with chromosomal instability (CIN), and genomically stable (GS) tumors. However, the gastric cancer (GC) with chromosomal instability remains insufficiently described and does not have effective markers for molecular and histological verification and diagnosis. The CIN subtype of GC is characterized by chromosomal instability, which is manifested by an increased frequency of aneuploidies and/or structural chromosomal rearrangements in tumor cells. Structural rearrangements in the CIN subtype of GC are not accidental and are commonly detected in chromosomal loci, being abnormal because of specific structural organization. The causes of CIN are still being discussed; however, according to recent data, aberrations in the TP53 gene may cause CIN development or worsen its phenotype. Clinically, patients with the CIN subtype of GC demonstrate poor survival, but receive the maximum benefit from adjuvant chemotherapy. In the review, we consider the molecular mechanisms and possible causes of chromosomal instability in GC, the common rearrangements of chromosomal loci and their impact on the development and clinical course of the disease, as well as the driver genes, their functions, and perspectives on their targeting in the CIN subtype of GC. [ABSTRACT FROM AUTHOR]

Published
2023
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7. The CFTR Gene Germline Heterozygous Pathogenic Variants in Russian Patients with Malignant Neoplasms and Healthy Carriers: 11,800 WGS Results

Author

Makarova, Maria, primary, Nemtsova, Marina, additional, Danishevich, Anastasiia, additional, Chernevskiy, Denis, additional, Belenikin, Maxim, additional, Krinitsina, Anastasiia, additional, Baranova, Elena, additional, Sagaydak, Olesya, additional, Vorontsova, Maria, additional, Khatkov, Igor, additional, Zhukova, Lyudmila, additional, Bodunova, Natalia, additional, Nikolaev, Sergey, additional, Byakhova, Mariya, additional, Semenova, Anna, additional, Galkin, Vsevolod, additional, and Gadzhieva, Saida, additional

Published
2023
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9. DNA Methylation and Prospects for Predicting the Therapeutic Effect of Neoadjuvant Chemotherapy for Triple-Negative and Luminal B Breast Cancer

Author

Sigin, Vladimir O., primary, Kalinkin, Alexey I., additional, Nikolaeva, Alexandra F., additional, Ignatova, Ekaterina O., additional, Kuznetsova, Ekaterina B., additional, Chesnokova, Galina G., additional, Litviakov, Nikolai V., additional, Tsyganov, Matvey M., additional, Ibragimova, Marina K., additional, Vinogradov, Ilya I., additional, Vinogradov, Maxim I., additional, Vinogradov, Igor Y., additional, Zaletaev, Dmitry V., additional, Nemtsova, Marina V., additional, Kutsev, Sergey I., additional, Tanas, Alexander S., additional, and Strelnikov, Vladimir V., additional

Published
2023
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13. Parental Origin of the RB1 Gene Mutations in Families with Low Penetrance Hereditary Retinoblastoma

Author

Alekseeva, Ekaterina A., primary, Babenko, Olga V., additional, Kozlova, Valentina M., additional, Ushakova, Tatiana L., additional, Kazubskaya, Tatiana P., additional, Nemtsova, Marina V., additional, Chesnokova, Galina G., additional, Mikhaylenko, Dmitry S., additional, Bure, Irina V., additional, Kalinkin, Alexey I., additional, Kuznetsova, Ekaterina B., additional, Tanas, Alexander S., additional, Kutsev, Sergey I., additional, Zaletaev, Dmitry V., additional, and Strelnikov, Vladimir V., additional

Published
2021
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14. Mutations in Epigenetic Regulation Genes in Gastric Cancer

Author

Nemtsova, Marina V., primary, Kalinkin, Alexey I., additional, Kuznetsova, Ekaterina B., additional, Bure, Irina V., additional, Alekseeva, Ekaterina A., additional, Bykov, Igor I., additional, Khorobrykh, Tatiana V., additional, Mikhaylenko, Dmitry S., additional, Tanas, Alexander S., additional, and Strelnikov, Vladimir V., additional

Published
2021
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16. Comprehensive Molecular Genetic Diagnostics of Birt-Hogg-Dube Syndrome in a Russian Patient with Renal Cancer and Lung Cysts: A Case Report

Author

Mikhaylenko, Dmitry S., primary, Matveev, Vsevolod B., additional, Filippova, Margarita G., additional, Anoshkin, Kirill I., additional, Kozlov, Nikolay A., additional, Khachaturyan, Alexander V., additional, Semyanikhina, Alexandra V., additional, Nifatov, Sergey D., additional, Tanas, Alexander S., additional, Nemtsova, Marina V., additional, and Zaletayev, Dmitry V., additional

Published
2021
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19. Secretion of Mutant DNA and mRNA by the Exosomes of Breast Cancer Cells

Author

Andreeva, Olga E., primary, Shchegolev, Yuri Y., additional, Scherbakov, Alexander M., additional, Mikhaevich, Ekaterina I., additional, Sorokin, Danila V., additional, Gudkova, Margarita V., additional, Bure, Irina V., additional, Kuznetsova, Ekaterina B., additional, Mikhaylenko, Dmitry S., additional, Nemtsova, Marina V., additional, Bagrov, Dmitry V., additional, and Krasil’nikov, Mikhail A., additional

Published
2021
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20. Long Non-Coding PROX1-AS1 Expression Correlates with Renal Cell Carcinoma Metastasis and Aggressiveness

Author

Rudzinska, Magdalena, primary, Czarnecka-Chrebelska, Karolina H., additional, Kuznetsova, Ekaterina B., additional, Maryanchik, Sofya V., additional, Parodi, Alessandro, additional, Korolev, Dmitry O., additional, Potoldykova, Nataliya, additional, Svetikova, Yulia, additional, Vinarov, Andrey Z., additional, Nemtsova, Marina V., additional, and Zamyatnin, Andrey A., additional

Published
2021
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21. Application Areas of Traditional Molecular Genetic Methods and NGS in relation to Hereditary Urological Cancer Diagnosis

Author

Mikhaylenko, Dmitry S., Tanas, Alexander S., Zaletaev, Dmitry V., and Nemtsova, Marina V.

Subjects
Article Subject
Abstract

Next generation sequencing (NGS) is widely used for diagnosing hereditary cancer syndromes. Often, exome sequencing and extended gene panel approaches are the only means that can be used to detect a pathogenic germline mutation in the case of multiple primary tumors, early onset, a family history of cancer, or a lack of specific signs associated with a particular syndrome. Certain germline mutations of oncogenes and tumor suppressor genes that determine specific clinical phenotypes may occur in mutation hot spots. Diagnosis of such cases, which involve hereditary cancer, does not require NGS, but may be made using PCR and Sanger sequencing. Diagnostic criteria and professional community guidelines developed for hereditary cancers of particular organs should be followed when ordering molecular diagnostic tests for a patient. This review focuses on urological oncology associated with germline mutations. Clinical signs and genetic diagnostic laboratory tests for hereditary forms of renal cell cancer, prostate cancer, and bladder cancer are summarized. While exome sequencing, or, conversely, traditional molecular genetic methods are the procedure of choice in some cases, in most situations, sequencing of multigene panels that are specifically aimed at detecting germline mutations in early onset renal cancer, prostate cancer, and bladder cancer seems to be the basic solution for molecular genetic diagnosis of hereditary cancers.

Published
2020
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22. Improvement of the Tikhonov Regularization Method for Solving the Inverse Problem of Mössbauer Spectroscopy

Author

Nemtsova Marina, Olga Nemtsova, and Grigorii Konygin

Subjects
Physics, 010304 chemical physics, Iterative method, Inverse problem, 010402 general chemistry, Condensed Matter Physics, 01 natural sciences, 0104 chemical sciences, Domain (software engineering), Tikhonov regularization, Distribution function, 0103 physical sciences, Mössbauer spectroscopy, Applied mathematics, Hyperfine structure, Spectroscopy
Abstract

An iterative algorithm for narrowing the definition domain of the distribution function of the hyperfine interaction parameter is proposed. The use of this algorithm increases the resolving power of the Tikhonov regularization method for solving the inverse problem of Mossbauer spectroscopy.

Published
2018

23. The role of multipolarity in quantitative analysis of EELFS spectra

Author

Olga Bakieva, Nemtsova Marina, and Olga Nemtsova

Subjects
Work (thermodynamics), Radiation, Chemistry, 02 engineering and technology, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Atomic and Molecular Physics, and Optics, Spectral line, Electronic, Optical and Magnetic Materials, X-ray absorption fine structure, K-edge, 0103 physical sciences, Physical and Theoretical Chemistry, Atomic physics, 010306 general physics, 0210 nano-technology, Absorption (electromagnetic radiation), Spectroscopy, Excitation, Electron ionization, Stoichiometry
Abstract

In this work we consider the possibility of carrying out a quantitative analysis of XAFS (X-ray Absorption Fine Structure)-like spectra formed by the excitation of the inner level of the atom of a solid by electron impact. The experimental EELFS spectra of M2,3 edge Fe and K edge of oxygen from surface of pure Fe and stoichiometric oxides FeO, Fe2O3 were obtained. The normalized oscillating parts from the corresponding experimental EELFS spectra were extracted. The analysis of normalized EELFS spectra were carried out taking into account the multipolarity of the excitation of the internal level of the atom and without it. The importance of taking into account the multipolarity of excitation of an atomic core level by an electron impact is illustrated.

Published
2018

26. Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response

Author

Mikhaylenko, Dmitry S., primary, Nemtsova, Marina V., additional, Bure, Irina V., additional, Kuznetsova, Ekaterina B., additional, Alekseeva, Ekaterina A., additional, Tarasov, Vadim V., additional, Lukashev, Alexander N., additional, Beloukhova, Marina I., additional, Deviatkin, Andrei A., additional, and Zamyatnin, Andrey A., additional

Published
2020
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27. Abnormal Hypermethylation of CpG Dinucleotides in Promoter Regions of Matrix Metalloproteinases Genes in Breast Cancer and its Relation to Epigenomic Subtypes and HER2 Overexpression

Author

Simonova, Olga A., primary, Kuznetsova, Ekaterina B., additional, Tanas, Alexander S., additional, Rudenko, Viktoria V., additional, Poddubskaya, Elena V., additional, Kekeeva, Tatiana V., additional, Trotsenko, Ivan D., additional, Larin, Sergey S., additional, Kutsev, Sergei I., additional, Zaletaev, Dmitry V., additional, Nemtsova, Marina V., additional, and Strelnikov, Vladimir V., additional

Published
2020
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29. Epigenetic Changes in the Pathogenesis of Rheumatoid Arthritis

Author

Nemtsova, Marina V., primary, Zaletaev, Dmitry V., additional, Bure, Irina V., additional, Mikhaylenko, Dmitry S., additional, Kuznetsova, Ekaterina B., additional, Alekseeva, Ekaterina A., additional, Beloukhova, Marina I., additional, Deviatkin, Andrei A., additional, Lukashev, Alexander N., additional, and Zamyatnin, Andrey A., additional

Published
2019
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31. Genome-wide methylotyping resolves breast cancer epigenetic heterogeneity and suggests novel therapeutic perspectives

Author

Tanas, Alexander S, primary, Sigin, Vladimir O, additional, Kalinkin, Alexey I, additional, Litviakov, Nikolai V, additional, Slonimskaya, Elena M, additional, Ibragimova, Marina K, additional, Ignatova, Ekaterina O, additional, Simonova, Olga A, additional, Kuznetsova, Ekaterina B, additional, Kekeeva, Tatiana V, additional, Larin, Sergey S, additional, Poddubskaya, Elena V, additional, Trotsenko, Ivan D, additional, Rudenko, Viktoria V, additional, Karandasheva, Kristina O, additional, Petrova, Kseniya D, additional, Tsyganov, Matvey M, additional, Deryusheva, Irina V, additional, Kazantseva, Polina V, additional, Doroshenko, Artem V, additional, Tarabanovskaya, Natalia A, additional, Chesnokova, Galina G, additional, Sekacheva, Marina I, additional, Nemtsova, Marina V, additional, Izhevskaya, Vera L, additional, Kutsev, Sergey I, additional, Zaletaev, Dmitry V, additional, and Strelnikov, Vladimir V, additional

Published
2019
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33. Implication of Gastric Cancer Molecular Genetic Markers in Surgical Practice

Author

Nemtsova, Marina V., primary, Strelnikov, Vladimir V., additional, Tanas, Alexander S., additional, Bykov, Igor I., additional, Zaletaev, Dmitry V., additional, Rudenko, Viktoria V., additional, Glukhov, Alexander I., additional, Kchorobrich, Tatiana V., additional, Li, Yi, additional, Tarasov, Vadim V., additional, Barreto, George E., additional, and Aliev, Gjumrakch, additional

Published
2017
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34. Rapid and affordable genome-wide bisulfite DNA sequencing by XmaI-reduced representation bisulfite sequencing

Author

Tanas, Alexander S, primary, Borisova, Marina E, additional, Kuznetsova, Ekaterina B, additional, Rudenko, Viktoria V, additional, Karandasheva, Kristina O, additional, Nemtsova, Marina V, additional, Izhevskaya, Vera L, additional, Simonova, Olga A, additional, Larin, Sergey S, additional, Zaletaev, Dmitry V, additional, and Strelnikov, Vladimir V, additional

Published
2017
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35. The method of extraction of subspectra with appreciably different values of hyperfine interaction parameters from Mössbauer spectra

Author

Nemtsova Marina and Olga Nemtsova

Subjects
Tikhonov regularization, Nuclear and High Energy Physics, Chemistry, Regularization (physics), Mössbauer spectroscopy, Analytical chemistry, Mossbauer spectra, Atomic physics, Instrumentation, Hyperfine structure, Spectral line, Probability density distribution
Abstract

The task of Mossbauer spectra processing of complex locally inhomogeneous or multi-phase systems is to reveal subspectral contributions with appreciably different values of hyperfine interaction parameters (HFI) in them. A universal method of processing such spectra is suggested which allows to extract the probability density distribution (PDD) of HFI parameters corresponding to the subspectra with essentially different parameters values. The basis of the method is Tikhonov’s regularization method with selection for each subspectrum its own value of the regularization parameter. The universal application of the method is demonstrated in the examples of processing real spectra with different sets of subspectral contributions.

Published
2006

36. The estimation of the error of the hyperfine interaction parameter distribution from Mössbauer spectra

Author

Nemtsova Marina, Elena Voronina, Olga Nemtsova, and Alexandr Leonidovich Ageev

Subjects
Physics, Tikhonov regularization, Nuclear and High Energy Physics, Distribution (mathematics), Exact solutions in general relativity, Singular value decomposition, Spectrum (functional analysis), Statistical physics, Inverse problem, Instrumentation, Hyperfine structure, Regularization (mathematics)
Abstract

The problems of the regularization parameter and estimation of the error of the hyperfine interaction (HFI) parameter distribution restored in processing Mossbauer spectra are discussed. The Tikhonov's regularization method is used as a method for solving the inverse problem. We consider the case when errors in the experimental data are due to statistics only. A procedure for estimating the distribution error, based on singular value decomposition (SVD) – decomposition with some additional information on the exact solution, is proposed. A direct simulation of the error is carried out for some model with the known HFI parameter distribution. The results obtained agree well with the error estimation calculated using SVD. As an example, the proposed procedure is applied to the Mossbauer spectrum of the non-ordered Fe–Si alloy.

Published
2002

38. Estimation of the error of hyperfine parameter distribution in Mössbauer spectroscopy

Author

Elena Voronina, Nemtsova Marina, Olga Nemtsova, and Alexandr Leonidovich Ageev

Subjects
Physics, Regularization (physics), Hadron, Mössbauer spectroscopy, General Physics and Astronomy, Parameter distribution, Statistical physics, Inverse problem, Hyperfine structure
Abstract

To obtain reliable information about the structural properties of samples studied by Mossbauer spectroscopy, a technique for estimating the error in the hyperfine parameter distribution in the uniform metric is proposed. The distribution error contains the error caused by the statistical spread of experimental data and the error of the method for solving the ill-posed inverse problem. A criterion of choice of the regularization parameter is proposed.

Published
2007

39. Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis.

Author

Dantsev, Ilya, Ivkin, Evgeniy, Tryakin, Aleksey, Godlevski, Dmitriy, Latyshev, Oleg, Rudenko, Victoriya, Mikhaylenko, Dmitry, Chernykh, Vyacheslav, Volodko, Elena, Okulov, Aleksey, Loran, Oleg, and Nemtsova, Marina

Abstract

Testicular microlithiasis (TM) is one of the symptoms of testicular dysgenesis syndrome (TDS). TM is particularly interesting as an informative marker of testicular germ cell tumors (TGCTs). KIT ligand gene (KITLG), BCL2 antagonist/killer 1 (BAK1), and sprouty RTK signaling antagonist 4 (SPRY4) genes are associated with a high risk of TGCTs, whereas bone morphogenetic protein 7 gene (BMP7), transforming growth factor beta receptor 3 gene (TGFBR3), and homeobox D cluster genes (HOXD) are related to TDS. Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis, we investigated allele and genotype frequencies for KITLG (rs995030, rs1508595), SPRY4 (rs4624820, rs6897876), BAK1 (rs210138), BMP7 (rs388286), TGFBR3 (rs12082710), and HOXD (rs17198432) in 142 TGCT patients, 137 TM patients, and 153 fertile men (control group). We found significant differences in the KITLG GG_rs995030 genotype in TM (P = 0.01) and TGCT patients (P = 0.0005) compared with the control. We also revealed strong associations between KITLG_rs1508595 and TM (G allele, P = 0.003; GG genotype, P = 0.01) and between KITLG_rs1508595 and TGCTs (G allele, P = 0.0001; GG genotype, P = 0.0007). Moreover, there was a significant difference in BMP7_rs388286 between the TGCT group and the control (T allele, P = 0.00004; TT genotype, P = 0.00006) and between the TM group and the control (T allele, P = 0.04). HOXD also demonstrated a strong association with TGCTs (rs17198432 A allele, P = 0.0001; AA genotype, P = 0.001). Furthermore, significant differences were found between the TGCT group and the control in the BAK1_rs210138 G allele (P = 0.03) and the GG genotype (P = 0.01). KITLG and BMP7 genes, associated with the development of TGCTs, may also be related to TM. In summary, the KITLG GG_rs995030, GG_rs1508595, BMP7 TT_rs388286, HOXD AA_rs17198432, and BAK1 GG_rs210138 genotypes were associated with a high risk of TGCT development. [ABSTRACT FROM AUTHOR]

Published
2018
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43. Positional Cloning of a Gene Involved in Hereditary Multiple Exostoses.

Author

Wuyts, Wim, Van Hul, Wim, Wauters, Jan, Nemtsova, Marina, Reyniers, Edwin, Van Hul, Els, De Boulle, Kristel, de Vries, Bert B. A., Hendrickx, Jan, Herrygers, Ilde, Bossuyt, Paul, Balemans, Wendy, Fransen, Erik, Vits, Lieve, Coucke, Paul, Nowak, Norma J., Shows, Thomas B., Mallet, Laurence, van den Ouweland, Ans M. W., and McGaughran, Julie

Published
1996
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