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9. Microscopic mechanism for the 1/8 magnetization plateau in SrCu_2(BO_3)_2

Author

Nemec, M., Foltin, G. R., and Schmidt, K. P.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

The frustrated quantum magnet SrCu_2(BO_3)_2 shows a remarkably rich phase diagram in an external magnetic field including a sequence of magnetization plateaux. The by far experimentally most studied and most prominent magnetization plateau is the 1/8 plateau. Theoretically, one expects that this material is well described by the Shastry-Sutherland model. But recent microscopic calculations indicate that the 1/8 plateau is energetically not favored. Here we report on a very simple microscopic mechanism which naturally leads to a 1/8 plateau for realistic values of the magnetic exchange constants. We show that the 1/8 plateau with a diamond unit cell benefits most compared to other plateau structures from quantum fluctuations which to a large part are induced by Dzyaloshinskii-Moriya interactions. Physically, such couplings result in kinetic terms in an effective hardcore boson description leading to a renormalization of the energy of the different plateaux structures which we treat in this work on the mean-field level. The stability of the resulting plateaux are discussed. Furthermore, our results indicate a series of stripe structures above 1/8 and a stable magnetization plateau at 1/6. Most qualitative aspects of our microscopic theory agree well with a recently formulated phenomenological theory for the experimental data of SrCu_2(BO_3)_2. Interestingly, our calculations point to a rather large ratio of the magnetic couplings in the Shastry-Sutherland model such that non-perturbative effects become essential for the understanding of the frustrated quantum magnet SrCu_2(BO_3)_2., Comment: 24 pages, 24 figures

Published
2012
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17. Lateral Approach to Total Knee Arthroplasty: Minimal Soft Tissue Invasion

Author

Mont, M. A., Bonutti, P. M., Chauhan, S. K., Axelson, S., Canonaco, A., Krijger, P., Nemec, M., Raistrick, J. W., Walsh, G., Rugo, E., Treacy, P., Hoeman, T., Hozack, William J., editor, Krismer, Martin, editor, Nogler, Michael, editor, Bonutti, Peter M., editor, Rachbauer, Franz, editor, Schaffer, Jonathan L., editor, and Donnelly, William J., editor

Published
2004
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19. POS0912 THE EFFECT OF A 24-WEEK TRAINING ON METABOLIC PARAMETERS OF SKELETAL MUSCLE CELLS DERIVED FROM PATIENTS WITH ESTABLISHED IDIOPATHIC INFLAMMATORY MYOPATHIES.

Author

Vokurková, M., primary, Vernerová, L., additional, Oreska, S., additional, Špiritović, M., additional, Klein, M., additional, Verner, Z., additional, Nemec, M., additional, Ukropec, J., additional, Ukropcová, B., additional, Tomčík, M., additional, and Vencovský, J., additional

Published
2022
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20. Analysis of the outer divertor hot spot activity in the protection video camera recordings at JET

Author

Drenik, A, Brezinsek, S, Carvalho, P, Huber, V, Osterman, N, Matthews, G, Nemec, M, Litaudon, X, Abduallev, S, Abhangi, M, Abreu, P, Afzal, M, Aggarwal, K, Ahlgren, T, Ahn, J, Aho-Mantila, L, Aiba, N, Airila, M, Albanese, R, Aldred, V, Alegre, D, Alessi, E, Aleynikov, P, Alfier, A, Alkseev, A, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amicucci, L, Amosov, V, Andersson Sunden, E, Angelone, M, Anghel, M, Angioni, C, Appel, L, Appelbee, C, Arena, P, Ariola, M, Arnichand, H, Arshad, S, Ash, A, Ashikawa, N, Aslanyan, V, Asunta, O, Auriemma, F, Austin, Y, Avotina, L, Axton, M, Ayres, C, Bacharis, M, Baciero, A, Baiao, D, Bailey, S, Baker, A, Balboa, I, Balden, M, Balshaw, N, Bament, R, Banks, J, Baranov, Y, Barnard, M, Barnes, D, Barnes, M, Barnsley, R, Baron Wiechec, A, Barrera Orte, L, Baruzzo, M, Basiuk, V, Bassan, M, Bastow, R, Batista, A, Batistoni, P, Baughan, R, Bauvir, B, Baylor, L, Bazylev, B, Beal, J, Beaumont, P, Beckers, M, Beckett, B, Becoulet, A, Bekris, N, Beldishevski, M, Bell, K, Belli, F, Bellinger, M, Belonohy, E, Ben Ayed, N, Benterman, N, Bergsaker, H, Bernardo, J, Bernert, M, Berry, M, Bertalot, L, Besliu, C, Beurskens, M, Bieg, B, Bielecki, J, Biewer, T, Bigi, M, Bilkova, P, Binda, F, Bisoffi, A, Bizarro, J, Bjorkas, C, Blackburn, J, Blackman, K, Blackman, T, Blanchard, P, Blatchford, P, Bobkov, V, Boboc, A, Bodnar, G, Bogar, O, Bolshakova, I, Bolzonella, T, Bonanomi, N, Bonelli, F, Boom, J, Booth, J, Borba, D, Borodin, D, Borodkina, I, Botrugno, A, Bottereau, C, Boulting, P, Bourdelle, C, Bowden, M, Bower, C, Bowman, C, Boyce, T, Boyd, C, Boyer, H, Bradshaw, J, Braic, V, Bravanec, R, Breizman, B, Bremond, S, Brennan, P, Breton, S, Brett, A, Bright, M, Brix, M, Broeckx, W, Brombin, M, Broslawski, A, Brown, D, Brown, M, Bruno, E, Bucalossi, J, Buch, J, Buchanan, J, Buckley, A, Budny, R, Bufferand, H, Bulman, M, Bulmer, N, Bunting, P, Buratti, P, Burckhart, A, Buscarino, A, Busse, A, Butler, N, Bykov, I, Byrne, J, Cahyna, P, Calabro, G, Calvo, I, Camenen, Y, Camp, P, Campling, D, Cane, J, Cannas, B, Capel, A, Card, P, Cardinali, A, Carman, P, Carr, M, Carralero, D, Carraro, L, Carvalho, B, Carvalho, I, Casson, F, Castaldo, C, Catarino, N, Caumont, J, Causa, F, Cavazzana, R, Cave-Ayland, K, Cavinato, M, Cecconello, M, Ceccuzzi, S, Cecil, E, Cenedese, A, Cesario, R, Challis, C, Chandler, M, Chandra, D, Chang, C, Chankin, A, Chapman, I, Chapman, S, Chernyshova, M, Chitarin, G, Ciraolo, G, Ciric, D, Citrin, J, Clairet, F, Clark, E, Clark, M, Clarkson, R, Clatworthy, D, Clements, C, Cleverly, M, Coad, J, Coates, P, Cobalt, A, Coccorese, V, Cocilovo, V, Coda, S, Coelho, R, Coenen, J, Coffey, I, Colas, L, Collins, S, Conka, D, Conroy, S, Conway, N, Coombs, D, Cooper, D, Cooper, S, Corradino, C, Corre, Y, Corrigan, G, Cortes, S, Coster, D, Couchman, A, Cox, M, Craciunescu, T, Cramp, S, Craven, R, Crisanti, F, Croci, G, Croft, D, Crombe, K, Crowe, R, Cruz, N, Cseh, G, Cufar, A, Cullen, A, Curuia, M, Czarnecka, A, Dabirikhah, H, Dalgliesh, P, Dalley, S, Dankowski, J, Darrow, D, Davies, O, Davis, W, Day, C, Day, I, De Bock, M, de Castro, A, de la Cal, E, de la Luna, E, De Masi, G, de Pablos, J, De Temmerman, G, De Tommasi, G, de Vries, P, Deakin, K, Deane, J, Degli Agostini, F, Dejarnac, R, Delabie, E, den Harder, N, Dendy, R, Denis, J, Denner, P, Devaux, S, Devynck, P, Di Maio, F, Di Siena, A, Di Troia, C, Dinca, P, D'Inca, R, Ding, B, Dittmar, T, Doerk, H, Doerner, R, Donne, T, Dorling, S, Dormido-Canto, S, Doswon, S, Douai, D, Doyle, P, Drewelow, P, Drews, P, Duckworth, P, Dumont, R, Dumortier, P, Dunai, D, Dunne, M, Duran, I, Durodie, F, Dutta, P, Duval, B, Dux, R, Dylst, K, Dzysiuk, N, Edappala, P, Edmond, J, Edwards, A, Edwards, J, Eich, T, Ekedahl, A, El-Jorf, R, Elsmore, C, Enachescu, M, Ericsson, G, Eriksson, F, Eriksson, J, Eriksson, L, Esposito, B, Esquembri, S, Esser, H, Esteve, D, Evans, B, Evans, G, Evison, G, Ewart, G, Fagan, D, Faitsch, M, Falie, D, Fanni, A, Fasoli, A, Faustin, J, Fawlk, N, Fazendeiro, L, Fedorczak, N, Felton, R, Fenton, K, Fernades, A, Fernandes, H, Ferreira, J, Fessey, J, Fevrier, O, Ficker, O, Field, A, Fietz, S, Figueiredo, A, Figueiredo, J, Fil, A, Finburg, P, Firdaouss, M, Fischer, U, Fittill, L, Fitzgerald, M, Flammini, D, Flanagan, J, Fleming, C, Flinders, K, Fonnesu, N, Fontdecaba, J, Formisano, A, Forsythe, L, Fortuna, L, Fortuna-Zalesna, E, Fortune, M, Foster, S, Franke, T, Franklin, T, Frasca, M, Frassinetti, L, Freisinger, M, Fresa, R, Frigione, D, Fuchs, V, Fuller, D, Futatani, S, Fyvie, J, Gal, K, Galassi, D, Galazka, K, Galdon-Quiroga, J, Gallagher, J, Gallart, D, Galvao, R, Gao, X, Gao, Y, Garcia, J, Garcia-Carrasco, A, Garcia-Munoz, M, Gardarein, J, Garzotti, L, Gaudio, P, Gauthier, E, Gear, D, Gee, S, Geiger, B, Gelfusa, M, Gerasimov, S, Gervasini, G, Gethins, M, Ghani, Z, Ghate, M, Gherendi, M, Giacalone, J, Giacomelli, L, Gibson, C, Giegerich, T, Gil, C, Gil, L, Gilligan, S, Gin, D, Giovannozzi, E, Girardo, J, Giroud, C, Giruzzi, G, Gloeggler, S, Godwin, J, Goff, J, Gohil, P, Goloborod'Ko, V, Gomes, R, Goncalves, B, Goniche, M, Goodliffe, M, Goodyear, A, Gorini, G, Gosk, M, Goulding, R, Goussarov, A, Gowland, R, Graham, B, Graham, M, Graves, J, Grazier, N, Grazier, P, Green, N, Greuner, H, Grierson, B, Griph, F, Grisolia, C, Grist, D, Groth, M, Grove, R, Grundy, C, Grzonka, J, Guard, D, Guerard, C, Guillemaut, C, Guirlet, R, Gurl, C, Utoh, H, Hackett, L, Hacquin, S, Hagar, A, Hager, R, Hakola, A, Halitovs, M, Hall, S, Hallworth Cook, S, Hamlyn-Harris, C, Hammond, K, Harrington, C, Harrison, J, Harting, D, Hasenbeck, F, Hatano, Y, Hatch, D, Haupt, T, Hawes, J, Hawkes, N, Hawkins, J, Hawkins, P, Haydon, P, Hayter, N, Hazel, S, Heesterman, P, Heinola, K, Hellesen, C, Hellsten, T, Helou, W, Hemming, O, Hender, T, Henderson, M, Henderson, S, Henriques, R, Hepple, D, Hermon, G, Hertout, P, Hidalgo, C, Highcock, E, Hill, M, Hillairet, J, Hillesheim, J, Hillis, D, Hizanidis, K, Hjalmarsson, A, Hobirk, J, Hodille, E, Hogben, C, Hogeweij, G, Hollingsworth, A, Hollis, S, Homfray, D, Horacek, J, Hornung, G, Horton, A, Horton, L, Horvath, L, Hotchin, S, Hough, M, Howarth, P, Hubbard, A, Huber, A, Huddleston, T, Hughes, M, Huijsmans, G, Hunter, C, Huynh, P, Hynes, A, Iglesias, D, Imazawa, N, Imbeaux, F, Imrisek, M, Incelli, M, Innocente, P, Irishkin, M, Ivanova-Stanik, I, Jachmich, S, Jacobsen, A, Jacquet, P, Jansons, J, Jardin, A, Jarvinen, A, Jaulmes, F, Jednorog, S, Jenkins, I, Jeong, C, Jepu, I, Joffrin, E, Johnson, R, Johnson, T, Johnston, J, Joita, L, Jones, G, Jones, T, Hoshino, K, Kallenbach, A, Kamiya, K, Kaniewski, J, Kantor, A, Kappatou, A, Karhunen, J, Karkinsky, D, Karnowska, I, Kaufman, M, Kaveney, G, Kazakov, Y, Kazantzidis, V, Keeling, D, Keenan, T, Keep, J, Kempenaars, M, Kennedy, C, Kenny, D, Kent, J, Kent, O, Khilkevich, E, Kim, H, Kinch, A, King, C, King, D, King, R, Kinna, D, Kiptily, V, Kirk, A, Kirov, K, Kirschner, A, Kizane, G, Klepper, C, Klix, A, Knight, P, Knipe, S, Knott, S, Kobuchi, T, Koechl, F, Kocsis, G, Kodeli, I, Kogan, L, Kogut, D, Koivuranta, S, Kominis, Y, Koepen, M, Kos, B, Koskela, T, Koslowski, H, Koubiti, M, Kovari, M, Kowalska-Strzeciwilk, E, Krasilnikov, A, Krasilnikov, V, Krawczyk, N, Kresina, M, Krieger, K, Krivska, A, Kruezi, U, Ksiazek, I, Kukushkin, A, Kundu, A, Kurki-Suonio, T, Kwak, S, Kwiatkowski, R, Kwon, O, Laguardia, L, Lahtinen, A, Laing, A, Lam, N, Lambertz, H, Lane, C, Lang, P, Lanthaler, S, Lapins, J, Lasa, A, Last, J, Laszynska, E, Lawless, R, Lawson, A, Lawson, K, Lazaros, A, Lazzaro, E, Leddy, J, Lee, S, Lefebvre, X, Leggate, H, Lehmann, J, Lehnen, M, Leichtle, D, Leichuer, P, Leipold, F, Lengar, I, Lennholm, M, Lerche, E, Lescinskis, A, Lesnoj, S, Letellier, E, Leyland, M, Leysen, W, Li, L, Liang, Y, Likonen, J, Linke, J, Linsmeier, C, Lipschultz, B, Liu, G, Liu, Y, Lo Schiavo, V, Loarer, T, Loarte, A, Lobel, R, Lomanowski, B, Lomas, P, Lonnroth, J, Lopez, J, Lopez-Razola, J, Lorenzini, R, Losada, U, Lovell, J, Loving, A, Lowry, C, Luce, T, Lucock, R, Lukin, A, Luna, C, Lungaroni, M, Lungu, C, Lungu, M, Lunniss, A, Lupelli, I, Lyssoivan, A, Macdonald, N, Macheta, P, Maczewa, K, Magesh, B, Maget, P, Maggi, C, Maier, H, Mailloux, J, Makkonen, T, Makwana, R, Malaquias, A, Malizia, A, Manas, P, Manning, A, Manso, M, Mantica, P, Mantsinen, M, Manzanares, A, Maquet, P, Marandet, Y, Marcenko, N, Marchetto, C, Marchuk, O, Marinelli, M, Marinucci, M, Markovic, T, Marocco, D, Marot, L, Marren, C, Marshal, R, Martin, A, Martin, Y, Martin de Aguilera, A, Martinez, F, Martin-Solis, J, Martynova, Y, Maruyama, S, Masiello, A, Maslov, M, Matejcik, S, Mattei, M, Maviglia, F, Mayer, M, Mayoral, M, May-Smith, T, Mazon, D, Mazzotta, C, Mcadams, R, Mccarthy, P, Mcclements, K, Mccormack, O, Mccullen, P, Mcdonald, D, Mcintosh, S, Mckean, R, Mckehon, J, Meadows, R, Meakins, A, Medina, F, Medland, M, Medley, S, Meigh, S, Meigs, A, Meisl, G, Meitner, S, Meneses, L, Menmuir, S, Mergia, K, Merrigan, I, Mertens, P, Meshchaninov, S, Messiaen, A, Meyer, H, Mianowski, S, Michling, R, Middleton-Gear, D, Miettunen, J, Militello, F, Militello-Asp, E, Miloshevsky, G, Mink, F, Minucci, S, Miyoshi, Y, Mlynar, J, Molina, D, Monakhov, I, Moneti, M, Mooney, R, Moradi, S, Mordijck, S, Moreira, L, Moreno, R, Moro, F, Morris, A, Morris, J, Moser, L, Mosher, S, Moulton, D, Murari, A, Muraro, A, Murphy, S, Asakura, N, Na, Y, Nabais, F, Naish, R, Nakano, T, Nardon, E, Naulin, V, Nave, M, Nedzelski, I, Nemtsev, G, Nespoli, F, Neto, A, Neu, R, Neverov, V, Newman, M, Nicholls, K, Nicolas, T, Nielsen, A, Nielsen, P, Nilsson, E, Nishijima, D, Noble, C, Nocente, M, Nodwell, D, Nordlund, K, Nordman, H, Nouailletas, R, Nunes, I, Oberkofler, M, Odupitan, T, Ogawa, M, O'Gorman, T, Okabayashi, M, Olney, R, Omolayo, O, O'Mullane, M, Ongena, J, Orsitto, F, Orszagh, J, Oswuigwe, B, Otin, R, Owen, A, Paccagnella, R, Pace, N, Pacella, D, Packer, L, Page, A, Pajuste, E, Palazzo, S, Pamela, S, Panja, S, Papp, P, Paprok, R, Parail, V, Park, M, Parra Diaz, F, Parsons, M, Pasqualotto, R, Patel, A, Pathak, S, Paton, D, Patten, H, Pau, A, Pawelec, E, Paz Soldan, C, Peackoc, A, Pearson, I, Pehkonen, S, Peluso, E, Penot, C, Pereira, A, Pereira, R, Pereira Puglia, P, Perez von Thun, C, Peruzzo, S, Peschanyi, S, Peterka, M, Petersson, P, Petravich, G, Petre, A, Petrella, N, Petrzilka, V, Peysson, Y, Pfefferle, D, Philipps, V, Pillon, M, Pintsuk, G, Piovesan, P, Pires dos Reis, A, Piron, L, Pironti, A, Pisano, F, Pitts, R, Pizzo, F, Plyusnin, V, Pomaro, N, Pompilian, O, Pool, P, Popovichev, S, Porfiri, M, Porosnicu, C, Porton, M, Possnert, G, Potzel, S, Powell, T, Pozzi, J, Prajapati, V, Prakash, R, Prestopino, G, Price, D, Price, M, Price, R, Prior, P, Proudfoot, R, Pucella, G, Puglia, P, Puiatti, M, Pulley, D, Purahoo, K, Puetterich, T, Rachlew, E, Rack, M, Ragona, R, Rainford, M, Rakha, A, Ramogida, G, Ranjan, S, Rapson, C, Rasmussen, J, Rathod, K, Ratta, G, Ratynskaia, S, Ravera, G, Rayner, C, Rebai, M, Reece, D, Reed, A, Refy, D, Regan, B, Regana, J, Reich, M, Reid, N, Reimold, F, Reinhart, M, Reinke, M, Reiser, D, Rendell, D, Reux, C, Reyes Cortes, S, Reynolds, S, Riccardo, V, Richardson, N, Riddle, K, Rigamonti, D, Rimini, F, Risner, J, Riva, M, Roach, C, Robins, R, Robinson, S, Robinson, T, Robson, D, Roccella, R, Rodionov, R, Rodrigues, P, Rodriguez, J, Rohde, V, Romanelli, F, Romanelli, M, Romanelli, S, Romazanov, J, Rowe, S, Rubel, M, Rubinacci, G, Rubino, G, Ruchko, L, Ruiz, M, Ruset, C, Rzadkiewicz, J, Saarelma, S, Sabot, R, Safi, E, Sagar, P, Saibene, G, Saint-Laurent, F, Salewski, M, Salmi, A, Salmon, R, Salzedas, F, Samaddar, D, Samm, U, Sandiford, D, Santa, P, Santala, M, Santos, B, Santucci, A, Sartori, F, Sartori, R, Sauter, O, Scannell, R, Schlummer, T, Schmid, K, Schmidt, V, Schmuck, S, Schneider, M, Schoepf, K, Schworer, D, Scott, S, Sergienko, G, Sertoli, M, Shabbir, A, Sharapov, S, Shaw, A, Shaw, R, Sheikh, H, Shepherd, A, Shevelev, A, Shumack, A, Sias, G, Sibbald, M, Sieglin, B, Silburn, S, Silva, A, Silva, C, Simmons, P, Simpson, J, Simpson-Hutchinson, J, Sinha, A, Sipila, S, Sips, A, Siren, P, Sirinelli, A, Sjostrand, H, Skiba, M, Skilton, R, Slabkowska, K, Slade, B, Smith, N, Smith, P, Smith, R, Smith, T, Smithies, M, Snoj, L, Soare, S, Solano, E, Somers, A, Sommariva, C, Sonato, P, Sopplesa, A, Sousa, J, Sozzi, C, Spagnolo, S, Spelzini, T, Spineanu, F, Stables, G, Stamatelatos, I, Stamp, M, Staniec, P, Stankunas, G, Stan-Sion, C, Stead, M, Stefanikova, E, Stepanov, I, Stephen, A, Stephen, M, Stevens, A, Steven, B, Strachan, J, Strand, P, Strauss, H, Strom, P, Stubbs, G, Studholme, W, Subba, F, Summers, H, Svensson, J, Swiderski, L, Szabolics, T, Szawlowski, M, Szepesi, G, Suzuki, T, Tal, B, Tala, T, Talbot, A, Talebzadeh, S, Taliercio, C, Tamain, P, Tame, C, Tang, W, Tardocchi, M, Taroni, L, Taylor, D, Taylor, K, Tegnered, D, Telesca, G, Teplova, N, Terranova, D, Testa, D, Tholerus, E, Thomas, J, Thomas, P, Thompson, A, Thompson, C, Thompson, V, Thorne, L, Thornton, A, Thrysoe, A, Tigwell, P, Tipton, N, Tiseanu, I, Tojo, H, Tokitani, M, Tolias, P, Tomes, M, Tonner, P, Towndrow, M, Trimble, P, Tripsky, M, Tsalas, M, Tsavalas, P, Tskhakaya Jun, D, Turner, I, Turner, M, Turnyanskiy, M, Tvalashvili, G, Tyrrell, S, Uccello, A, Ul-Abidin, Z, Uljanovs, J, Ulyatt, D, Urano, H, Uytdenhouwen, I, Vadgama, A, Valcarcel, D, Valentinuzzi, M, Valisa, M, Vallejos Olivares, P, Valovic, M, Van De Mortel, M, Van Eester, D, Van Renterghem, W, van Rooij, G, Varje, J, Varoutis, S, Vartanian, S, Vasava, K, Vasilopoulou, T, Vega, J, Verdoolaege, G, Verhoeven, R, Verona, C, Verona Rinati, G, Veshchev, E, Vianello, N, Vicente, J, Viezzer, E, Villari, S, Villone, F, Vincenzi, P, Vinyar, I, Viola, B, Vitins, A, Vizvary, Z, Vlad, M, Voitsekhovitch, I, Vondracek, P, Vora, N, Vu, T, Pires de Sa, W, Wakeling, B, Waldon, C, Walkden, N, Walker, M, Walker, R, Walsh, M, Wang, E, Wang, N, Warder, S, Warren, R, Waterhouse, J, Watkins, N, Watts, C, Wauters, T, Weckmann, A, Weiland, J, Weisen, H, Weiszflog, M, Wellstood, C, West, A, Wheatley, M, Whetham, S, Whitehead, A, Whitehead, B, Widdowson, A, Wiesen, S, Wilkinson, J, Williams, J, Williams, M, Wilson, A, Wilson, D, Wilson, H, Wilson, J, Wischmeier, M, Withenshaw, G, Withycombe, A, Witts, D, Wood, D, Wood, R, Woodley, C, Wray, S, Wright, J, Wu, J, Wukitch, S, Wynn, A, Xu, T, Yadikin, D, Yanling, W, Yao, L, Yavorskij, V, Yoo, M, Young, C, Young, D, Young, I, Young, R, Zacks, J, Zagorski, R, Zaitsev, F, Zanino, R, Zarins, A, Zastrow, K, Zerbini, M, Zhang, W, Zhou, Y, Zilli, E, Zoita, V, Zoletnik, S, Zychor, I, Drenik A., Brezinsek S., Carvalho P., Huber V., Osterman N., Matthews G. F., Nemec M., Litaudon X., Abduallev S., Abhangi M., Abreu P., Afzal M., Aggarwal K. M., Ahlgren T., Ahn J. H., Aho-Mantila L., Aiba N., Airila M., Albanese R., Aldred V., Alegre D., Alessi E., Aleynikov P., Alfier A., Alkseev A., Allinson M., Alper B., Alves E., Ambrosino G., Ambrosino R., Amicucci L., Amosov V., Andersson Sunden E., Angelone M., Anghel M., Angioni C., Appel L., Appelbee C., Arena P., Ariola M., Arnichand H., Arshad S., Ash A., Ashikawa N., Aslanyan V., Asunta O., Auriemma F., Austin Y., Avotina L., Axton M. D., Ayres C., Bacharis M., Baciero A., Baiao D., Bailey S., Baker A., Balboa I., Balden M., Balshaw N., Bament R., Banks J. W., Baranov Y. F., Barnard M. A., Barnes D., Barnes M., Barnsley R., Baron Wiechec A., Barrera Orte L., Baruzzo M., Basiuk V., Bassan M., Bastow R., Batista A., Batistoni P., Baughan R., Bauvir B., Baylor L., Bazylev B., Beal J., Beaumont P. S., Beckers M., Beckett B., Becoulet A., Bekris N., Beldishevski M., Bell K., Belli F., Bellinger M., Belonohy E., Ben Ayed N., Benterman N. A., Bergsaker H., Bernardo J., Bernert M., Berry M., Bertalot L., Besliu C., Beurskens M., Bieg B., Bielecki J., Biewer T., Bigi M., Bilkova P., Binda F., Bisoffi A., Bizarro J. P. S., Bjorkas C., Blackburn J., Blackman K., Blackman T. R., Blanchard P., Blatchford P., Bobkov V., Boboc A., Bodnar G., Bogar O., Bolshakova I., Bolzonella T., Bonanomi N., Bonelli F., Boom J., Booth J., Borba D., Borodin D., Borodkina I., Botrugno A., Bottereau C., Boulting P., Bourdelle C., Bowden M., Bower C., Bowman C., Boyce T., Boyd C., Boyer H. J., Bradshaw J. M. A., Braic V., Bravanec R., Breizman B., Bremond S., Brennan P. D., Breton S., Brett A., Bright M. D. J., Brix M., Broeckx W., Brombin M., Broslawski A., Brown D. P. D., Brown M., Bruno E., Bucalossi J., Buch J., Buchanan J., Buckley A., Budny R., Bufferand H., Bulman M., Bulmer N., Bunting P., Buratti P., Burckhart A., Buscarino A., Busse A., Butler N. K., Bykov I., Byrne J., Cahyna P., Calabro G., Calvo I., Camenen Y., Camp P., Campling D. C., Cane J., Cannas B., Capel A. J., Card P. J., Cardinali A., Carman P., Carr M., Carralero D., Carraro L., Carvalho B. B., Carvalho I., Casson F. J., Castaldo C., Catarino N., Caumont J., Causa F., Cavazzana R., Cave-Ayland K., Cavinato M., Cecconello M., Ceccuzzi S., Cecil E., Cenedese A., Cesario R., Challis C. D., Chandler M., Chandra D., Chang C. S., Chankin A., Chapman I. T., Chapman S. C., Chernyshova M., Chitarin G., Ciraolo G., Ciric D., Citrin J., Clairet F., Clark E., Clark M., Clarkson R., Clatworthy D., Clements C., Cleverly M., Coad J. P., Coates P. A., Cobalt A., Coccorese V., Cocilovo V., Coda S., Coelho R., Coenen J. W., Coffey I., Colas L., Collins S., Conka D., Conroy S., Conway N., Coombs D., Cooper D., Cooper S. R., Corradino C., Corre Y., Corrigan G., Cortes S., Coster D., Couchman A. S., Cox M. P., Craciunescu T., Cramp S., Craven R., Crisanti F., Croci G., Croft D., Crombe K., Crowe R., Cruz N., Cseh G., Cufar A., Cullen A., Curuia M., Czarnecka A., Dabirikhah H., Dalgliesh P., Dalley S., Dankowski J., Darrow D., Davies O., Davis W., Day C., Day I. E., De Bock M., de Castro A., de la Cal E., de la Luna E., De Masi G., de Pablos J. L., De Temmerman G., De Tommasi G., de Vries P., Deakin K., Deane J., Degli Agostini F., Dejarnac R., Delabie E., den Harder N., Dendy R. O., Denis J., Denner P., Devaux S., Devynck P., Di Maio F., Di Siena A., Di Troia C., Dinca P., D'Inca R., Ding B., Dittmar T., Doerk H., Doerner R. P., Donne T., Dorling S. E., Dormido-Canto S., Doswon S., Douai D., Doyle P. T., Drewelow P., Drews P., Duckworth P., Dumont R., Dumortier P., Dunai D., Dunne M., Duran I., Durodie F., Dutta P., Duval B. P., Dux R., Dylst K., Dzysiuk N., Edappala P. V., Edmond J., Edwards A. M., Edwards J., Eich T., Ekedahl A., El-Jorf R., Elsmore C. G., Enachescu M., Ericsson G., Eriksson F., Eriksson J., Eriksson L. G., Esposito B., Esquembri S., Esser H. G., Esteve D., Evans B., Evans G. E., Evison G., Ewart G. D., Fagan D., Faitsch M., Falie D., Fanni A., Fasoli A., Faustin J. M., Fawlk N., Fazendeiro L., Fedorczak N., Felton R. C., Fenton K., Fernades A., Fernandes H., Ferreira J., Fessey J. A., Fevrier O., Ficker O., Field A., Fietz S., Figueiredo A., Figueiredo J., Fil A., Finburg P., Firdaouss M., Fischer U., Fittill L., Fitzgerald M., Flammini D., Flanagan J., Fleming C., Flinders K., Fonnesu N., Fontdecaba J. 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S., Grisolia C., Grist D., Groth M., Grove R., Grundy C. N., Grzonka J., Guard D., Guerard C., Guillemaut C., Guirlet R., Gurl C., Utoh H. H., Hackett L. J., Hacquin S., Hagar A., Hager R., Hakola A., Halitovs M., Hall S. J., Hallworth Cook S. P., Hamlyn-Harris C., Hammond K., Harrington C., Harrison J., Harting D., Hasenbeck F., Hatano Y., Hatch D. R., Haupt T. D. V., Hawes J., Hawkes N. C., Hawkins J., Hawkins P., Haydon P. W., Hayter N., Hazel S., Heesterman P. J. L., Heinola K., Hellesen C., Hellsten T., Helou W., Hemming O. N., Hender T. C., Henderson M., Henderson S. S., Henriques R., Hepple D., Hermon G., Hertout P., Hidalgo C., Highcock E. G., Hill M., Hillairet J., Hillesheim J., Hillis D., Hizanidis K., Hjalmarsson A., Hobirk J., Hodille E., Hogben C. H. A., Hogeweij G. M. D., Hollingsworth A., Hollis S., Homfray D. A., Horacek J., Hornung G., Horton A. R., Horton L. D., Horvath L., Hotchin S. P., Hough M. R., Howarth P. J., Hubbard A., Huber A., Huddleston T. M., Hughes M., Huijsmans G. T. A., Hunter C. L., Huynh P., Hynes A. M., Iglesias D., Imazawa N., Imbeaux F., Imrisek M., Incelli M., Innocente P., Irishkin M., Ivanova-Stanik I., Jachmich S., Jacobsen A. S., Jacquet P., Jansons J., Jardin A., Jarvinen A., Jaulmes F., Jednorog S., Jenkins I., Jeong C., Jepu I., Joffrin E., Johnson R., Johnson T., Johnston J., Joita L., Jones G., Jones T. T. C., Hoshino K. K., Kallenbach A., Kamiya K., Kaniewski J., Kantor A., Kappatou A., Karhunen J., Karkinsky D., Karnowska I., Kaufman M., Kaveney G., Kazakov Y., Kazantzidis V., Keeling D. L., Keenan T., Keep J., Kempenaars M., Kennedy C., Kenny D., Kent J., Kent O. N., Khilkevich E., Kim H. T., Kim H. S., Kinch A., King C., King D., King R. F., Kinna D. J., Kiptily V., Kirk A., Kirov K., Kirschner A., Kizane G., Klepper C., Klix A., Knight P., Knipe S. J., Knott S., Kobuchi T., Koechl F., Kocsis G., Kodeli I., Kogan L., Kogut D., Koivuranta S., Kominis Y., Koepen M., Kos B., Koskela T., Koslowski H. R., Koubiti M., Kovari M., Kowalska-Strzeciwilk E., Krasilnikov A., Krasilnikov V., Krawczyk N., Kresina M., Krieger K., Krivska A., Kruezi U., Ksiazek I., Kukushkin A., Kundu A., Kurki-Suonio T., Kwak S., Kwiatkowski R., Kwon O. J., Laguardia L., Lahtinen A., Laing A., Lam N., Lambertz H. T., Lane C., Lang P. T., Lanthaler S., Lapins J., Lasa A., Last J. R., Laszynska E., Lawless R., Lawson A., Lawson K. D., Lazaros A., Lazzaro E., Leddy J., Lee S., Lefebvre X., Leggate H. J., Lehmann J., Lehnen M., Leichtle D., Leichuer P., Leipold F., Lengar I., Lennholm M., Lerche E., Lescinskis A., lesnoj S., Letellier E., Leyland M., Leysen W., Li L., Liang Y., Likonen J., Linke J., Linsmeier C., Lipschultz B., Liu G., Liu Y., Lo Schiavo V. P., Loarer T., Loarte A., Lobel R. C., Lomanowski B., Lomas P. J., Lonnroth J., Lopez J. M., Lopez-Razola J., Lorenzini R., Losada U., Lovell J. J., Loving A. B., Lowry C., Luce T., Lucock R. M. A., Lukin A., Luna C., Lungaroni M., Lungu C. P., Lungu M., Lunniss A., Lupelli I., Lyssoivan A., Macdonald N., Macheta P., Maczewa K., Magesh B., Maget P., Maggi C., Maier H., Mailloux J., Makkonen T., Makwana R., Malaquias A., Malizia A., Manas P., Manning A., Manso M. E., Mantica P., Mantsinen M., Manzanares A., Maquet P., Marandet Y., Marcenko N., Marchetto C., Marchuk O., Marinelli M., Marinucci M., Markovic T., Marocco D., Marot L., Marren C. A., Marshal R., Martin A., Martin Y., Martin de Aguilera A., Martinez F. J., Martin-Solis J. R., Martynova Y., Maruyama S., Masiello A., Maslov M., Matejcik S., Mattei M., Maviglia F., Mayer M., Mayoral M. L., May-Smith T., Mazon D., Mazzotta C., McAdams R., McCarthy P. J., McClements K. G., McCormack O., McCullen P. A., McDonald D., McIntosh S., McKean R., McKehon J., Meadows R. C., Meakins A., Medina F., Medland M., Medley S., Meigh S., Meigs A. G., Meisl G., Meitner S., Meneses L., Menmuir S., Mergia K., Merrigan I. R., Mertens P., Meshchaninov S., Messiaen A., Meyer H., Mianowski S., Michling R., Middleton-Gear D., Miettunen J., Militello F., Militello-Asp E., Miloshevsky G., Mink F., Minucci S., Miyoshi Y., Mlynar J., Molina D., Monakhov I., Moneti M., Mooney R., Moradi S., Mordijck S., Moreira L., Moreno R., Moro F., Morris A. W., Morris J., Moser L., Mosher S., Moulton D., Murari A., Muraro A., Murphy S., Asakura N. N., Na Y. S., Nabais F., Naish R., Nakano T., Nardon E., Naulin V., Nave M. F. F., Nedzelski I., Nemtsev G., Nespoli F., Neto A., Neu R., Neverov V. S., Newman M., Nicholls K. J., Nicolas T., Nielsen A. H., Nielsen P., Nilsson E., Nishijima D., Noble C., Nocente M., Nodwell D., Nordlund K., Nordman H., Nouailletas R., Nunes I., Oberkofler M., Odupitan T., Ogawa M. T., O'Gorman T., Okabayashi M., Olney R., Omolayo O., O'Mullane M., Ongena J., Orsitto F., Orszagh J., Oswuigwe B. I., Otin R., Owen A., Paccagnella R., Pace N., Pacella D., Packer L. W., Page A., Pajuste E., Palazzo S., Pamela S., Panja S., Papp P., Paprok R., Parail V., Park M., Parra Diaz F., Parsons M., Pasqualotto R., Patel A., Pathak S., Paton D., Patten H., Pau A., Pawelec E., Paz Soldan C., Peackoc A., Pearson I. J., Pehkonen S. P., Peluso E., Penot C., Pereira A., Pereira R., Pereira Puglia P. P., Perez von Thun C., Peruzzo S., Peschanyi S., Peterka M., Petersson P., Petravich G., Petre A., Petrella N., Petrzilka V., Peysson Y., Pfefferle D., Philipps V., Pillon M., Pintsuk G., Piovesan P., Pires dos Reis A., Piron L., Pironti A., Pisano F., Pitts R., Pizzo F., Plyusnin V., Pomaro N., Pompilian O. G., Pool P. J., Popovichev S., Porfiri M. T., Porosnicu C., Porton M., Possnert G., Potzel S., Powell T., Pozzi J., Prajapati V., Prakash R., Prestopino G., Price D., Price M., Price R., Prior P., Proudfoot R., Pucella G., Puglia P., Puiatti M. E., Pulley D., Purahoo K., Puetterich T., Rachlew E., Rack M., Ragona R., Rainford M. S. J., Rakha A., Ramogida G., Ranjan S., Rapson C. J., Rasmussen J. J., Rathod K., Ratta G., Ratynskaia S., Ravera G., Rayner C., Rebai M., Reece D., Reed A., Refy D., Regan B., Regana J., Reich M., Reid N., Reimold F., Reinhart M., Reinke M., Reiser D., Rendell D., Reux C., Reyes Cortes S. D. A., Reynolds S., Riccardo V., Richardson N., Riddle K., Rigamonti D., Rimini F. G., Risner J., Riva M., Roach C., Robins R. J., Robinson S. A., Robinson T., Robson D. W., Roccella R., Rodionov R., Rodrigues P., Rodriguez J., Rohde V., Romanelli F., Romanelli M., Romanelli S., Romazanov J., Rowe S., Rubel M., Rubinacci G., Rubino G., Ruchko L., Ruiz M., Ruset C., Rzadkiewicz J., Saarelma S., Sabot R., Safi E., Sagar P., Saibene G., Saint-Laurent F., Salewski M., Salmi A., Salmon R., Salzedas F., Samaddar D., Samm U., Sandiford D., Santa P., Santala M. I. K., Santos B., Santucci A., Sartori F., Sartori R., Sauter O., Scannell R., Schlummer T., Schmid K., Schmidt V., Schmuck S., Schneider M., Schoepf K., Schworer D., Scott S. D., Sergienko G., Sertoli M., Shabbir A., Sharapov S. E., Shaw A., Shaw R., Sheikh H., Shepherd A., Shevelev A., Shumack A., Sias G., Sibbald M., Sieglin B., Silburn S., Silva A., Silva C., Simmons P. A., Simpson J., Simpson-Hutchinson J., Sinha A., Sipila S. K., Sips A. C. C., Siren P., Sirinelli A., Sjostrand H., Skiba M., Skilton R., Slabkowska K., Slade B., Smith N., Smith P. G., Smith R., Smith T. J., Smithies M., Snoj L., Soare S., Solano E. R., Somers A., Sommariva C., Sonato P., Sopplesa A., Sousa J., Sozzi C., Spagnolo S., Spelzini T., Spineanu F., Stables G., Stamatelatos I., Stamp M. F., Staniec P., Stankunas G., Stan-Sion C., Stead M. J., Stefanikova E., Stepanov I., Stephen A. V., Stephen M., Stevens A., Steven B. D., Strachan J., Strand P., Strauss H. 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G., Young C., Young D., Young I. D., Young R., Zacks J., Zagorski R., Zaitsev F. S., Zanino R., Zarins A., Zastrow K. D., Zerbini M., Zhang W., Zhou Y., Zilli E., Zoita V., Zoletnik S., and Zychor I.

Abstract

Hot spots on the divertor tiles at JET result in overestimation of the tile surface temperature which causes unnecessary termination of pulses. However, the appearance of hot spots can also indicate the condition of the divertor tile surfaces. To analyse the behaviour of the hot spots in the outer divertor tiles of JET, a simple image processing algorithm is developed. The algorithm isolates areas of bright pixels in the camera image and compares them to previously identified hot spots. The activity of the hot spots is then linked to values of other signals and parameters in the same time intervals. The operation of the detection algorithm was studied in a limited pulse range with high hot spot activity on the divertor tiles 5, 6 and 7. This allowed us to optimise the values of the controlling parameters. Then, the wider applicability of the method has been demonstrated by the analysis of the hot spot behaviour in a whole experimental campaign.

Published
2019

26. Newton-Krylov algorithm for aerodynamic design using the Navier-Stokes equations

Author

Nemec, M. and Zingg, D.W.

Subjects
Turbulence -- Models, Aerodynamics -- Research, Viscous flow -- Research, Aerospace and defense industries, Business
Abstract

A Newton-Krylov algorithm is presented for two-dimensional Navier-Stokes aerodynamic shape optimization problems. The algorithm is applied to both the discrete-adjoint and the discrete flow-sensitivity methods for calculating the gradient of the objective function. The adjoint and flow-sensitivity equations are solved using a novel preconditioned generalized minimum residual (GMRES) strategy. Together with a complete linearization of the discretized Navier-Stokes and turbulence model equations, this results in an accurate and efficient evaluation of the gradient. Furthermore, fast flow solutions are obtained using the same preconditioned GMRES strategy in conjunction with an inexact Newton approach. The performance of the new algorithm is demonstrated for several design examples, including inverse design, lift-constrained drag minimization, lift enhancement, and maximization of lift-to-drag ratio. In all examples, the norm of the gradient is reduced by several orders of magnitude, indicating that a local minimum has been obtained. By the use of the ad joint method, the gradient is obtained in from one-fifth to one-half of the time required to converge a flow solution.

Published
2002

27. Altered dynamics of lipid metabolism in muscle cells from patients with idiopathic inflammatory myopathy is ameliorated by 6 months of training

Author

Nemec, M., primary, Vernerová, L., additional, Laiferová, N., additional, Balážová, M., additional, Vokurková, M., additional, Kurdiová, T., additional, Oreská, S., additional, Kubínová, K., additional, Klein, M., additional, Špiritović, M., additional, Tomčík, M., additional, Vencovský, J., additional, Ukropec, J., additional, and Ukropcová, B., additional

Published
2020
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29. Factors Influencing the Involvement of Nurses in Preventive Care and Health Literacy in the Czech Republic

Author

Kotherová Zuzana, Caithamlová Martina, and Nemec Miroslav

Subjects
primary care, preventive care, health literacy, nurses, czech republic, Political science
Abstract

The aims of this article were to discuss the position of Czech nurses in the country's health care system, to assess their role in the preventive care and health literacy (HL) promotion and to define main factors, which may negatively impact their involvement in preventive care. We checked by the questionnaire, what is the position of nurses working in the primary care in the Czech health system, how nurses perceive their role in the preventive care and which factors influence their involvement. The expert opinion method was used to discover main barriers limiting the role of primary care nurses in prevention and HL promotion. A total of 204 nurses participated between May and June 2022 in an online survey. The survey was completed by interviews with five experts. Our main finding is that nurses are willing to be proactive in prevention and HL; however, their autonomy and responsibilities in these areas remain rather low. The main factors influencing the involvement of nurses in preventive care are the type of practice, age of nurses, and the administrative burden. The expert interviews propose that nurses are overloaded and that, in many cases, they do not really know their responsibilities in the field of preventive care. The core policy lesson derived from our research is that appropriate definition of roles and responsibilities of nurses and their related empowerment might represent critical measures towards increasing health system resilience and sustainability.

Published
2023
Full Text
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31. Mitochondrial respiratory states and rate

Author

Gnaiger, E., Aasander Frostner, E., Abdul Karim, N., Abumrad, NA., Acuna-Castroviejo, D., Adiele, RC., Ahn, B., Ali, SS., Alton, L., Alves, MG., Amati, F., Amoedo, ND., Andreadou, I., Arago, M., Aral, C., Arandarcikaite, O., Armand, AS., Arnould, T., Avram, VF., Bailey, DM., Bajpeyi, S., Bajzikova, M., Bakker, BM., Barlow, J., Bastos Sant'Anna Silva, AC., Batterson, P., Battino, M., Bazil, J., Beard, DA., Bednarczyk, P., Bello, F., Ben-Shachar, D., Bergdahl, A., Berge, RK., Bergmeister, L., Bernardi, P., Berridge, MV., Bettinazzi, S., Bishop, D., Blier, PU., Blindheim, DF., Boardman, NT., Boetker, HE., Borchard, S., Boros, M., Borsheim, E., Borutaite, V., Botella, J., Bouillaud, F., Bouitbir, J., Boushel, RC., Bovard, J., Breton, S., Brown, DA., Brown, GC., Brown, RA., Brozinick, JT., Buettner, GR., Burtscher, J., Calabria, E., Calbet, JA., Calzia, E., Cannon, DT., Cano Sanchez, M., Canto, AC., Cardoso, LHD., Carvalho, E., Casado Pinna, M., Cassar, S., Cassina, AM., Castelo, MP., Castro, L., Cavalcanti-de-Albuquerque, JP., Cervinkova, Z., Chabi, B., Chakrabarti, L., Chakrabarti, S., Chaurasia, B., Chen, Q., Chicco, AJ., Chinopoulos, C., Chowdhury, SK., Cizmarova, B., Clementi, E., Coen, PM., Cohen, BH., Coker, RH., Collin, A., Crisostomo, L., Dahdah, N., Dalgaard, LT., Dambrova, M., Danhelovska, T., Darveau, CA., Das, AM., Dash, RK., Davidova, E., Davis, MS., De Goede, P., De Palma, C., Dembinska-Kiec, A., Detraux, D., Devaux, Y., Di Marcello, M., Dias, TR., Distefano, G., Doermann, N., Doerrier, C., Dong, L., Donnelly, C., Drahota, Z., Duarte, FV., Dubouchaud, H., Duchen, MR., Dumas, JF., Durham, WJ., Dymkowska, D., Dyrstad, SE., Dyson, A., Dzialowski, EM., Eaton, S., Ehinger, J., Elmer, E., Endlicher, R., Engin, AB., Escames, G., Ezrova, Z., Falk, MJ., Fell, DA., Ferdinandy, P., Ferko, M., Ferreira, JCB., Ferreira, R., Ferri, A., Fessel, JP., Filipovska, A., Fisar, Z., Fischer, C., Fischer, M., Fisher, G., Fisher, JJ., Ford, E., Fornaro, M., Galina, A., Galkin, A., Gallee, L., Galli, GL., Gama Perez, P., Gan, Z., Ganetzky, R., Garcia-Rivas, G., Garcia-Roves, PM., Garcia-Souza, LF., Garipi, E., Garlid, KD., Garrabou, G., Garten, A., Gastaldelli, A., Gayen, J., Genders, AJ., Genova, ML., Giovarelli, M., Goncalo Teixeira da Silva, R., Goncalves, DF., Gonzalez-Armenta, JL., Gonzalez-Freire, M., Gonzalo, H., Goodpaster, BH., Gorr, TA., Gourlay, CW., Granata, C., Grefte, S., Guarch, ME., Gueguen, N., Gumeni, S., Haas, CB., Haavik, J., Haendeler, J., Haider, M., Hamann, A., Han, J., Han, WH., Hancock, CR., Hand, SC., Handl, J., Hargreaves, IP., Harper, ME., Harrison, DK., Hassan, H., Hausenloy, DJ., Heales, SJR., Heiestad, C., Hellgren, KT., Hepple, RT., Hernansanz-Agustin, P., Hewakapuge, S., Hickey, AJ., Ho, DH., Hoehn, KL., Hoel, F., Holland, OJ., Holloway, GP., Hoppel, CL., Hoppel, F., Houstek, J., Huete-Ortega, M., Hyrossova, P., Iglesias-Gonzalez, J., Irving, BA., Isola, R., Iyer, S., Jackson, CB., Jadiya, P., Jana, PF., Jang, DH., Jang, YC., Janowska, J., Jansen, K., Jansen-Duerr, P., Jansone, B., Jarmuszkiewicz, W., Jaskiewicz, A., Jedlicka, J., Jespersen, NR., Jha, RK., Jurczak, MJ., Jurk, D., Kaambre, T., Kaczor, JJ., Kainulainen, H., Kampa, RP., Kandel, SM., Kane, DA., Kapferer, W., Kappler, L., Karabatsiakis, A., Karavaeva, I., Karkucinska-Wieckowska, A., Kaur, S., Keijer, J., Keller, MA., Keppner, G., Khamoui, AV., Kidere, D., Kilbaugh, T., Kim, HK., Kim, JKS., Klepinin, A., Klepinina, L., Klingenspor, M., Klocker, H., Komlodi, T., Koopman, WJH., Kopitar-Jerala, N., Kowaltowski, AJ., Kozlov, AV., Krajcova, A., Krako Jakovljevic, N., Kristal, BS., Krycer, JR., Kuang, J., Kucera, O., Kuka, J., Kwak, HB., Kwast, K., Laasmaa, M., Labieniec-Watala, M., Lagarrigue, S., Lai, N., Land, JM., Lane, N., Laner, V., Lanza, IR., Laranjinha, J., Larsen, TS., Lavery, GG., Lazou, A., Lee, HK., Leeuwenburgh, C., Lehti, M., Lemieux, H., Lenaz, G., Lerfall, J., Li, PA., Li Puma, L., Liepins, E., Liu, J., Lopez, LC., Lucchinetti, E., Ma, T., Macedo, MP., Maciej, S., MacMillan-Crow, LA., Majtnerova, P., Makarova, E., Makrecka-Kuka, M., Malik, AN., Markova, M., Martin, DS., Martins, AD., Martins, JD., Maseko, TE., Maull, F., Mazat, JP., McKenna, HT., McKenzie, M., Menze, MA., Merz, T., Meszaros, AT., Methner, A., Michalak, S., Moellering, DR., Moisoi, N., Molina, AJA., Montaigne, D., Moore, AL., Moreau, K., Moreira, BP., Moreno-Sanchez, R., Mracek, T., Muccini, AM., Munro, D., Muntane, J., Muntean, DM., Murray, AJ., Musiol, E., Nabben, M., Nair, KS., Nehlin, JO., Nemec, M., Neufer, PD., Neuzil, J., Neviere, R., Newsom, SA., Nozickova, K., O'Brien, KA., O'Gorman, D., Olgar, Y., Oliveira, B., Oliveira, MF., Oliveira, MT., Oliveira, PF., Oliveira, PJ., Orynbayeva, Z., Osiewacz, HD., Pak, YK., Pallotta, ML., Palmeira, CM., Parajuli, N., Passos, JF., Passrugger, M., Patel, HH., Pavlova, N., Pecina, P., Pedersen, TM., Pereira da Silva Grilo da Silva, F., Pereira, SP., Perez Valencia, JA., Perks, KL., Pesta, D., Petit, PX., Pettersen, IKN., Pichaud, N., Pichler, I., Piel, S., Pietka, TA., Pino, MF., Pirkmajer, S., Plangger, M., Porter, C., Porter, RK., Procaccio, V., Prochownik, EV., Prola, A., Pulinilkunnil, T., Puskarich, MA., Puurand, M., Radenkovic, F., Ramzan, R., Rattan, SIS., Reboredo, P., Renner-Sattler, K., Rial, E., Robinson, MM., Roden, M., Rodriguez, E., Rodriguez-Enriquez, S., Roesland, GV., Rohlena, J., Rolo, AP., Ropelle, ER., Rossignol, R., Rossiter, HB., Rubelj, I., Rybacka-Mossakowska, J., Saada, A., Safaei, Z., Saharnaz, S., Salin, K., Salvadego, D., Sandi, C., Saner, N., Sanz, A., Sazanov, LA., Scatena, R., Schartner, M., Scheibye-Knudsen, M., Schilling, JM., Schlattner, U., Schoenfeld, P., Schots, PC., Schulz, R., Schwarzer, C., Scott, GR., Selman, C., Shabalina, IG., Sharma, P., Sharma, V., Shevchuk, I., Shirazi, R., Shiroma, JG., Siewiera, K., Silber, AM., Silva, AM., Sims, CA., Singer, D., Singh, BK., Skolik, R., Smenes, BT., Smith, J., Soares, FAA., Sobotka, O., Sokolova, I., Sonkar, VK., Sowton, AP., Sparagna, GC., Sparks, LM., Spinazzi, M., Stankova, P., Starr, J., Stary, C., Stelfa, G., Stepto, NK., Stiban, J., Stier, A., Stocker, R., Storder, J., Sumbalova, Z., Suomalainen, A., Suravajhala, P., Svalbe, B., Swerdlow, RH., Swiniuch, D., Szabo, I., Szewczyk, A., Szibor, M., Tanaka, M., Tandler, B., Tarnopolsky, MA., Tausan, D., Tavernarakis, N., Tepp, K., Thakkar, H., Thapa, M., Thyfault, JP., Tomar, D., Ton, R., Torp, MK., Towheed, A., Tretter, L., Trewin, AJ., Trifunovic, A., Trivigno, C., Tronstad, KJ., Trougakos, IP., Truu, L., Tuncay, E., Turan, B., Tyrrell, DJ., Urban, T., Valentine, JM., Van Bergen, NJ., Van Hove, J., Varricchio, F., Vella, J., Vendelin, M., Vercesi, AE., Victor, VM., Vieira Ligo Teixeira, C., Vidimce, J., Viel, C., Vieyra, A., Vilks, K., Villena, JA., Vincent, V., Vinogradov, AD., Viscomi, C., Vitorino, RMP., Vogt, S., Volani, C., Volska, K., Votion, DM., Vujacic-Mirski, K., Wagner, BA., Ward, ML., Warnsmann, V., Wasserman, DH., Watala, C., Wei, YH., Whitfield, J., Wickert, A., Wieckowski, MR., Wiesner, RJ., Williams, CM., Winwood-Smith, H., Wohlgemuth, SE., Wohlwend, M., Wolff, JN., Wrutniak-Cabello, C., Wuest, RCI., Yokota, T., Zablocki, K., Zanon, A., Zanou, N., Zaugg, K., Zaugg, M., Zdrazilova, L., Zhang, Y., Zhang, YZ., Zikova, A., Zischka, H., Zorzano, A., and Zvejniece, L.

Subjects
Mitochondrial respiratory control, coupling control, mitochondrial preparations, protonmotive force, uncoupling, oxidative phosphorylation, OXPHOS, efficiency, electron transfer, ET, proton leak, LEAK, residual oxygen consumption, ROX, State 2, State 3, State 4, normalization, flow, flux, O2
Abstract

As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminologyconcerning mitochondrial respiratory states and rates has become increasingly apparent. Thechemiosmotic theoryestablishes the mechanism of energy transformationandcoupling in oxidative phosphorylation. Theunifying concept of the protonmotive force providestheframeworkfordeveloping a consistent theoretical foundation ofmitochondrial physiology and bioenergetics.We followguidelines of the International Union of Pure and Applied Chemistry(IUPAC)onterminology inphysical chemistry, extended by considerationsofopen systems and thermodynamicsof irreversible processes.Theconcept-driven constructive terminology incorporates the meaning of each quantity and alignsconcepts and symbols withthe nomenclature of classicalbioenergetics. We endeavour to provide a balanced view ofmitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes.Uniform standards for evaluation of respiratory states and rates will ultimatelycontribute to reproducibility between laboratories and thussupport the development of databases of mitochondrial respiratory function in species, tissues, and cells.Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery.

Published
2019

33. Effect of supplementing gilts' diets with different levels of vitamin E and different fats on the humoral and cellular immunity of gilts and their progeny

Author

Nemec, M., Butler, G., Hidiroglou, M., Farnworth, E.R., and Nielsen, K.

Subjects
Sows -- Food and nutrition, Vitamin E in animal nutrition -- Research, Fat -- Health aspects, Immunity -- Research, Zoology and wildlife conservation
Abstract

The effects of supplementing gestation and lactation diets of gilts with different combinations of vitamin E at or above NRC recommended levels (22, 44, or 88 IU/kg during gestation and 55, 110, and 220 IU/kg during lactation) and types of fat (5% added tallow or fish oil or no added fat) on humoral and cellular immunity of gilts and their pigs were evaluated. With only two exceptions, total IgG, IgM, and IgA in colostrum, milk, and plasma of gilts and in plasma of their pigs did not show significant (P > .05) effects, and no interactions between vitamin E and fat supplementation were observed. Cellular immunity was measured as lymphocyte proliferation response to phytohemagglutinin (PHA), concanavalin A (Con A), purified protein derivative of Mycobacterium avium, keyhole limpet hemocyanin, Escherichia coli lipopolysaccharide (LPS), and Salmonella typhimurium LPS. Only the nonspecific mitogens, PHA and Con A, induced proliferation of gilt and pig lymphocytes. Fish oil supplementation in the gilts' diets resulted in lower (P < .01) postpartum PHA response in gilts and slower (P < .05) acquisition of PHA response in newborn pigs compared with groups with added tallow or no added fat. The vitamin E supplementation did not have a significant positive effect on either PHA or Con A response of the gilts. However, the rate of acquisition of PHA response and Con A response in newborn pigs was greater (P < .05) for groups supplemented with 110 and 220 IU/kg of vitamin E than for the group supplemented with 55 IU/kg vitamin E.

Published
1994

34. On the Use of CAD and Cartesian Methods for Aerodynamic Optimization

Author

Nemec, M, Aftosmis, M. J, and Pulliam, T. H

Subjects
Aircraft Design, Testing And Performance
Abstract

The objective for this paper is to present the development of an optimization capability for Curt3D, a Cartesian inviscid-flow analysis package. We present the construction of a new optimization framework and we focus on the following issues: 1) Component-based geometry parameterization approach using parametric-CAD models and CAPRI. A novel geometry server is introduced that addresses the issue of parallel efficiency while only sparingly consuming CAD resources; 2) The use of genetic and gradient-based algorithms for three-dimensional aerodynamic design problems. The influence of noise on the optimization methods is studied. Our goal is to create a responsive and automated framework that efficiently identifies design modifications that result in substantial performance improvements. In addition, we examine the architectural issues associated with the deployment of a CAD-based approach in a heterogeneous parallel computing environment that contains both CAD workstations and dedicated compute engines. We demonstrate the effectiveness of the framework for a design problem that features topology changes and complex geometry.

Published
2004

35. Comparison of Evolutionary (Genetic) Algorithm and Adjoint Methods for Multi-Objective Viscous Airfoil Optimizations

Author

Pulliam, T. H, Nemec, M, Holst, T, Zingg, D. W, and Kwak, Dochan

Subjects
Numerical Analysis
Abstract

A comparison between an Evolutionary Algorithm (EA) and an Adjoint-Gradient (AG) Method applied to a two-dimensional Navier-Stokes code for airfoil design is presented. Both approaches use a common function evaluation code, the steady-state explicit part of the code,ARC2D. The parameterization of the design space is a common B-spline approach for an airfoil surface, which together with a common griding approach, restricts the AG and EA to the same design space. Results are presented for a class of viscous transonic airfoils in which the optimization tradeoff between drag minimization as one objective and lift maximization as another, produces the multi-objective design space. Comparisons are made for efficiency, accuracy and design consistency.

Published
2002

36. Platelets mitochondrial function depends on CoQ10 concentration in winter, not in spring season

Author

Mojto, Zuzana Rausová, Nemec M, A Chladekova, Anna Gvozdjáková, Kubalová M, Jarmila Kucharská, Kuzmiaková Z, Ol’ga Vančová, and Zuzana Sumbalová

Subjects
Blood Platelets, medicine.medical_specialty, Physiology, Ubiquinone, 030310 physiology, Biophysics, Oxidative phosphorylation, medicine.disease_cause, Antioxidants, 03 medical and health sciences, Respirometry, chemistry.chemical_compound, Internal medicine, Respiration, medicine, Humans, Respiratory function, Platelet, Coenzyme Q10, 0303 health sciences, Chemistry, General Medicine, Mitochondria, Endocrinology, Mitochondrial respiratory chain, Seasons, Oxidative stress
Abstract

Seasonal variations in temperature may influence the physiological and pathological metabolic pathways, concentrations of antioxidants, degree of oxidative stress and mitochondrial function. The aim of this study was to evaluate platelet mitochondrial function in human subjects during seasonal variations in temperature. Two groups of healthy young subjects were enroled in the study. Winter group, mean outside temperature was 4.77°C and Spring group, mean outside temperature was 24.32°C. High-resolution respirometry method was used for determination of mitochondrial respiration and oxidative phosphorylation in platelets. Concentrations of coenzyme Q10 (CoQ10) and tocopherols were determined in platelets, blood and plasma. Our data showed slightly (not significantly) reduced respiration in intact platelets, basal and ADP-stimulated mitochondrial respiration at Complex I, as well as CoQ10-TOTAL and α-tocopherol concentrations in winter. The concentration of γ-tocopherol was higher in winter. Platelet mitochondrial ATP production depended on platelet CoQ10-TOTAL concentration in winter, not in spring. We conclude that seasonal temperature participates in the mechanism of platelet mitochondrial respiratory chain function and oxidative phosphorylation that depends on their CoQ10-TOTAL concentration at lower winter outside temperature. CoQ10 supplementation may improve platelets mitochondrial ATP production at winter season. High-resolution respirometry offers sensitive method for detection of changes of platelets mitochondrial respiratory function.

Published
2018

37. Mitochondrial respiratory states and rates: Building blocks of mitochondrial physiology (Part 1)

Author

Gnaiger, E., Ahn, B., Alves, M. G., Amati, F., Aral, C., Arandarčikaitė, O., Åsander Frostner, E., Bailey, David M., Bastos Sant'Anna Silva, A. C., Battino, M., Beard, D. A., Newsom, S., Robinson, M. M., Patel, H. H., Buettner, G. R., Pecina, P., Shevchuk, I., Pereira da Silva Grilo da Silva, F., Ben-Shachar, D., Pesta, D., Goodpaster, B. H., Zorzano, Antonio, Petit, P. X., Pichaud, N., Pirkmajer, S., Porter, R. K., Wagner, B. A., Pranger, F., Rohlena, J., Prochownik, E. V., Siewiera, K., Røsland, G. V., Ehinger, J., Rossiter, H. B., Towheed, A., Rybacka-Mossakowska, J., Dias, T., Salvadego, D., Jansen-Dürr, P., Scatena, R., Schartner, M., Scheibye-Knudsen, Morten, Breton, S., Cardoso, L.H.D., Schilling, J. M., Singer, D., Schlattner, U., Brown, R. A., Sobotka, O., Spinazzi, M., Ward, M. L., Brown, G. C., Gonzalo, H., Stankova, P., Labieniec-Watala, M., Stier, A., Stocker, R., Sumbalova, Zuzana, Doerrier, C., Suravajhala, P., Tretter, L., Tanaka, M., Duchen, Michael R., Trivigno, C., Tronstad, K. J., Carvalho, Eugenia, Drahota, Z., Jackson, C. B., Trougakos, I. P., Tyrrell, D. J., Urban, T., Velika, B., Gorr, T. A., Vercesi, A. E., Watala, C., Victor, V. M., Grefte, S., Wei, Y. H., Wieckowski, M. R., O'Gorman, D., Kucera, O., Wohlwend, M., Wolff, J., Wuest, R.C.I., Zaugg, K., Jespersen, N. R., Zaugg, M., Casado, Marta, Calabria, E., Červinková, Zuzana, Chang, S. C., Radenkovic, F., Moisoi, N., Chicco, A. J., Chinopoulos, C., Coen, P. M., Collins, J. L., Lai, N., Crisóstomo, L., Elmer, E., Davis, M. S., Han, J., Endlicher, R., Pak, Y. K., Fell, D. A., Jha, R. K., Ferko, M., Nozickova, K., Ferreira, J.C.B., Scott, G. R., Filipovska, A., Fisar, Z., Fisher, J., García-Rovés, Pablo M., Molina, A.J.A., Garcia-Souza, L. F., Harrison, D. K., Genova, M. L., Kaambre, T., Hellgren, K. T., Hernansanz-Agustín, Pablo, Laner, V., Holland, O., Puurand, M., Hoppel, C. L., Tepp, K., Houstek, J., Hunger, M., Iglesias-Gonzalez, J., Oliveira, P. F., Irving, B. A., Kane, D. A., Iyer, S., Orynbayeva, Z., Kappler, L., Karabatsiakis, A., Montaigne, D., Oliveira, P. J., Schoenfeld, P., Keijer, J., Keppner, G., Komlodi, T., Kopitar-Jerala, N., Reboredo, P., Krako Jakovljevic, N., Larsen, T. S., Kuang, J., Renner-Sattler, K., Lee, H. K., Lemieux, H., Bishop, D., Tandler, B., Lerfall, J., Lucchinetti, E., MacMillan-Crow, L. A., Makrecka-Kuka, M., Shabalina, I. G., Meszaros, A. T., Moore, A. L., Michalak, S., Moreira, B. P., Mracek, T., Distefano, G., Villena, J. A., Muntané, Jordi, Muntean, D. M., Murray, A. J., Nedergaard, J., Tomar, D., Nemec, M., Palmeira, C. M., and European Commission

Subjects
Mitochondrial preparations, Mitochondrial respiratory control, Proton leak, Flux, Flow, Coupling control, Efficiency, State 4, Protonmotive force, State 2, OXPHOS, Residual oxygen consumption, State 3, Electron transfer, Normalization, ROX, Oxidative phosphorylation, LEAK, ET
Abstract

Supporting co-authors: Bakker BM, Bernardi P, Boetker HE, Borsheim E, Borutaitė V, Bouitbir J, Calbet JA, Calzia E, Chaurasia B, Clementi E, Coker RH, Collin A, Das AM, De Palma C, Dubouchaud H, Durham WJ, Dyrstad SE, Engin AB, Fornaro M, Gan Z, Garlid KD, Garten A, Gourlay CW, Granata C, Haas CB, Haavik J, Haendeler J, Hand SC, Hepple RT, Hickey AJ, Hoel F, Jang DH, Kainulainen H, Khamoui AV, Klingenspor M, Koopman WJH, Kowaltowski AJ, Krajcova A, Lane N, Lenaz G, Malik A, Markova M, Mazat JP, Menze MA, Methner A, Neuzil J, Oliveira MT, Pallotta ML, Parajuli N, Pettersen IKN, Porter C, Pulinilkunnil T, Ropelle ER, Salin K, Sandi C, Sazanov LA, Silber AM, Skolik R, Smenes BT, Soares FAA, Sokolova I, Sonkar VK, Swerdlow RH, Szabo I, Trifunovic A, Thyfault JP, Valentine JM, Vieyra A, Votion DM, Williams C, Zischka H, As the knowledge base and importance of mitochondrial physiology to human health expand, the necessity for harmonizing nomenclature concerning mitochondrial respiratory states and rates has become increasingly apparent. Clarity of concept and consistency of nomenclature are key trademarks of a research field. These trademarks facilitate effective transdisciplinary communication, education, and ultimately further discovery. Peter Mitchell’s chemiosmotic theory establishes the link between vectorial and scalar energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theory and nomenclature for mitochondrial physiology and bioenergetics. Herein, we follow IUPAC guidelines on general terms of physical chemistry, extended by considerations on open systems and irreversible thermodynamics. We align the nomenclature and symbols of classical bioenergetics with a concept-driven constructive terminology to express the meaning of each quantity clearly and consistently. In this position statement, in the frame of COST Action MitoEAGLE, we endeavour to provide a balanced view on mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately support the development of databases of mitochondrial respiratory function in species, tissues, and cells., We thank M. Beno for management assistance. Supported by COST Action CA15203 MitoEAGLE and K-Regio project MitoFit (E.G.).

Published
2018
Full Text
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39. Mitochondrial respiratory states and rates: Building blocks of mitochondrial physiology (Part 1)

Author

European Commission, Gnaiger, E., Ahn, B., Alves, M. G., Amati, F., Aral, C., Arandarčikaitė, O., Åsander Frostner, E., Bailey, David M., Bastos Sant'Anna Silva, A. C., Battino, M., Beard, D. A., Newsom, S., Robinson, M. M., Patel, H. H., Buettner, G. R., Pecina, P., Shevchuk, I., Pereira da Silva Grilo da Silva, F., Ben-Shachar, D., Pesta, D., Goodpaster, B. H., Zorzano, Antonio, Petit, P. X., Pichaud, N., Pirkmajer, S., Porter, R. K., Wagner, B. A., Pranger, F., Rohlena, J., Prochownik, E. V., Siewiera, K., Røsland, G. V., Ehinger, J., Rossiter, H. B., Towheed, A., Rybacka-Mossakowska, J., Dias, T., Salvadego, D., Jansen-Dürr, P., Scatena, R., Schartner, M., Scheibye-Knudsen, Morten, Breton, S., Cardoso, L.H.D., Schilling, J. M., Singer, D., Schlattner, U., Brown, R. A., Sobotka, O., Spinazzi, M., Ward, M. L., Brown, G. C., Gonzalo, H., Stankova, P., Labieniec-Watala, M., Stier, A., Stocker, R., Sumbalova, Zuzana, Doerrier, C., Suravajhala, P., Tretter, L., Tanaka, M., Duchen, Michael R., Trivigno, C., Tronstad, K. J., Carvalho, Eugenia, Drahota, Z., Jackson, C. B., Trougakos, I. P., Tyrrell, D. J., Urban, T., Velika, B., Gorr, T. A., Vercesi, A. E., Watala, C., Victor, V. M., Grefte, S., Wei, Y. H., Wieckowski, M. R., O'Gorman, D., Kucera, O., Wohlwend, M., Wolff, J., Wuest, R.C.I., Zaugg, K., Jespersen, N. R., Zaugg, M., Casado, Marta, Calabria, E., Červinková, Zuzana, Chang, S. C., Radenkovic, F., Moisoi, N., Chicco, A. J., Chinopoulos, C., Coen, P. M., Collins, J. L., Lai, N., Crisóstomo, L., Elmer, E., Davis, M. S., Han, J., Endlicher, R., Pak, Y. K., Fell, D. A., Jha, R. K., Ferko, M., Nozickova, K., Ferreira, J.C.B., Scott, G. R., Filipovska, A., Fisar, Z., Fisher, J., García-Rovés, Pablo M., Molina, A.J.A., Garcia-Souza, L. F., Harrison, D. K., Genova, M. L., Kaambre, T., Hellgren, K. T., Hernansanz-Agustín, Pablo, Laner, V., Holland, O., Puurand, M., Hoppel, C. L., Tepp, K., Houstek, J., Hunger, M., Iglesias-Gonzalez, J., Oliveira, P. F., Irving, B. A., Kane, D. A., Iyer, S., Orynbayeva, Z., Kappler, L., Karabatsiakis, A., Montaigne, D., Oliveira, P. J., Schoenfeld, P., Keijer, J., Keppner, G., Komlodi, T., Kopitar-Jerala, N., Reboredo, P., Krako Jakovljevic, N., Larsen, T. S., Kuang, J., Renner-Sattler, K., Lee, H. K., Lemieux, H., Bishop, D., Tandler, B., Lerfall, J., Lucchinetti, E., MacMillan-Crow, L. A., Makrecka-Kuka, M., Shabalina, I. G., Meszaros, A. T., Moore, A. L., Michalak, S., Moreira, B. P., Mracek, T., Distefano, G., Villena, J. A., Muntané, Jordi, Muntean, D. M., Murray, A. J., Nedergaard, J., Tomar, D., Nemec, M., Palmeira, C. M., European Commission, Gnaiger, E., Ahn, B., Alves, M. G., Amati, F., Aral, C., Arandarčikaitė, O., Åsander Frostner, E., Bailey, David M., Bastos Sant'Anna Silva, A. C., Battino, M., Beard, D. A., Newsom, S., Robinson, M. M., Patel, H. H., Buettner, G. R., Pecina, P., Shevchuk, I., Pereira da Silva Grilo da Silva, F., Ben-Shachar, D., Pesta, D., Goodpaster, B. H., Zorzano, Antonio, Petit, P. X., Pichaud, N., Pirkmajer, S., Porter, R. K., Wagner, B. A., Pranger, F., Rohlena, J., Prochownik, E. V., Siewiera, K., Røsland, G. V., Ehinger, J., Rossiter, H. B., Towheed, A., Rybacka-Mossakowska, J., Dias, T., Salvadego, D., Jansen-Dürr, P., Scatena, R., Schartner, M., Scheibye-Knudsen, Morten, Breton, S., Cardoso, L.H.D., Schilling, J. M., Singer, D., Schlattner, U., Brown, R. A., Sobotka, O., Spinazzi, M., Ward, M. L., Brown, G. C., Gonzalo, H., Stankova, P., Labieniec-Watala, M., Stier, A., Stocker, R., Sumbalova, Zuzana, Doerrier, C., Suravajhala, P., Tretter, L., Tanaka, M., Duchen, Michael R., Trivigno, C., Tronstad, K. J., Carvalho, Eugenia, Drahota, Z., Jackson, C. B., Trougakos, I. P., Tyrrell, D. J., Urban, T., Velika, B., Gorr, T. A., Vercesi, A. E., Watala, C., Victor, V. M., Grefte, S., Wei, Y. H., Wieckowski, M. R., O'Gorman, D., Kucera, O., Wohlwend, M., Wolff, J., Wuest, R.C.I., Zaugg, K., Jespersen, N. R., Zaugg, M., Casado, Marta, Calabria, E., Červinková, Zuzana, Chang, S. C., Radenkovic, F., Moisoi, N., Chicco, A. J., Chinopoulos, C., Coen, P. M., Collins, J. L., Lai, N., Crisóstomo, L., Elmer, E., Davis, M. S., Han, J., Endlicher, R., Pak, Y. K., Fell, D. A., Jha, R. K., Ferko, M., Nozickova, K., Ferreira, J.C.B., Scott, G. R., Filipovska, A., Fisar, Z., Fisher, J., García-Rovés, Pablo M., Molina, A.J.A., Garcia-Souza, L. F., Harrison, D. K., Genova, M. L., Kaambre, T., Hellgren, K. T., Hernansanz-Agustín, Pablo, Laner, V., Holland, O., Puurand, M., Hoppel, C. L., Tepp, K., Houstek, J., Hunger, M., Iglesias-Gonzalez, J., Oliveira, P. F., Irving, B. A., Kane, D. A., Iyer, S., Orynbayeva, Z., Kappler, L., Karabatsiakis, A., Montaigne, D., Oliveira, P. J., Schoenfeld, P., Keijer, J., Keppner, G., Komlodi, T., Kopitar-Jerala, N., Reboredo, P., Krako Jakovljevic, N., Larsen, T. S., Kuang, J., Renner-Sattler, K., Lee, H. K., Lemieux, H., Bishop, D., Tandler, B., Lerfall, J., Lucchinetti, E., MacMillan-Crow, L. A., Makrecka-Kuka, M., Shabalina, I. G., Meszaros, A. T., Moore, A. L., Michalak, S., Moreira, B. P., Mracek, T., Distefano, G., Villena, J. A., Muntané, Jordi, Muntean, D. M., Murray, A. J., Nedergaard, J., Tomar, D., Nemec, M., and Palmeira, C. M.

Abstract

As the knowledge base and importance of mitochondrial physiology to human health expand, the necessity for harmonizing nomenclature concerning mitochondrial respiratory states and rates has become increasingly apparent. Clarity of concept and consistency of nomenclature are key trademarks of a research field. These trademarks facilitate effective transdisciplinary communication, education, and ultimately further discovery. Peter Mitchell’s chemiosmotic theory establishes the link between vectorial and scalar energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theory and nomenclature for mitochondrial physiology and bioenergetics. Herein, we follow IUPAC guidelines on general terms of physical chemistry, extended by considerations on open systems and irreversible thermodynamics. We align the nomenclature and symbols of classical bioenergetics with a concept-driven constructive terminology to express the meaning of each quantity clearly and consistently. In this position statement, in the frame of COST Action MitoEAGLE, we endeavour to provide a balanced view on mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately support the development of databases of mitochondrial respiratory function in species, tissues, and cells.

Published
2018

40. Altered dynamics of lipid metabolism in muscle cells from patients with idiopathic inflammatory myopathy is ameliorated by 6 months of training.

Author

Nemec, M., Vernerová, L., Laiferová, N., Balážová, M., Vokurková, M., Kurdiová, T., Oreská, S., Kubínová, K., Klein, M., Špiritović, M., Tomčík, M., Vencovský, J., Ukropec, J., and Ukropcová, B.

Subjects
*MUSCLE cells, *LIPID metabolism, *MUSCLE metabolism, *CELL metabolism, *SATURATED fatty acids, *MYOSITIS
Abstract

Key points: Regular exercise improves muscle functional capacity and clinical state of patients with idiopathic inflammatory myopathy (IIM).In our study, we used an in vitro model of human primary muscle cell cultures, derived from IIM patients before and after a 6‐month intensive supervised training intervention to assess the impact of disease and exercise on lipid metabolism dynamics.We provide evidence that muscle cells from IIM patients display altered dynamics of lipid metabolism and impaired adaptive response to saturated fatty acid load compared to healthy controls.A 6‐month intensive supervised exercise training intervention in patients with IIM mitigated disease effects in their cultured muscle cells, improving or normalizing their capacity to handle lipids.These findings highlight the putative role of intrinsic metabolic defects of skeletal muscle in the pathogenesis of IIM and the positive impact of exercise, maintained in vitro by yet unknown epigenetic mechanisms. Exercise improves skeletal muscle function, clinical state and quality of life in patients with idiopathic inflammatory myopathy (IIM). Our aim was to identify disease‐related metabolic perturbations and the impact of exercise in skeletal muscle cells of IIM patients. Patients underwent a 6‐month intensive supervised training intervention. Muscle function, anthropometric and metabolic parameters were examined and muscle cell cultures were established (m. vastus lateralis; Bergström needle biopsy) before and after training from patients and sedentary age/sex/body mass index‐matched controls. [14C]Palmitate was used to determine fat oxidation and lipid synthesis (thin layer chromatography). Cells were exposed to a chronic (3 days) and acute (3 h) metabolic challenge (the saturated fatty acid palmitate, 100 μm). Reduced oxidative (intermediate metabolites, −49%, P = 0.034) and non‐oxidative (diglycerides, −38%, P = 0.013) lipid metabolism was identified in palmitate‐treated muscle cells from IIM patients compared to controls. Three days of palmitate exposure elicited distinct regulation of oxidative phosphorylation (OxPHOS) complex IV and complex V/ATP synthase (P = 0.012/0.005) and adipose triglyceride lipase in patients compared to controls (P = 0.045) (immunoblotting). Importantly, 6 months of training in IIM patients improved lipid metabolism (CO2, P = 0.010; intermediate metabolites, P = 0.041) and activation of AMP kinase (P = 0.007), and nearly normalized palmitate‐induced changes in OxPHOS proteins in myotubes from IIM patients, in parallel with improvements of patients' clinical state. Myotubes from IIM patients displayed altered dynamics of lipid metabolism and impaired response to metabolic challenge with saturated fatty acid. Our observations suggest that metabolic defects intrinsic to skeletal muscle could represent non‐immune pathomechanisms, which can contribute to muscle weakness in IIM. A 6‐month training intervention mitigated disease effects in muscle cells in vitro, indicating the existence of epigenetic regulatory mechanisms. Key points: Regular exercise improves muscle functional capacity and clinical state of patients with idiopathic inflammatory myopathy (IIM).In our study, we used an in vitro model of human primary muscle cell cultures, derived from IIM patients before and after a 6‐month intensive supervised training intervention to assess the impact of disease and exercise on lipid metabolism dynamics.We provide evidence that muscle cells from IIM patients display altered dynamics of lipid metabolism and impaired adaptive response to saturated fatty acid load compared to healthy controls.A 6‐month intensive supervised exercise training intervention in patients with IIM mitigated disease effects in their cultured muscle cells, improving or normalizing their capacity to handle lipids.These findings highlight the putative role of intrinsic metabolic defects of skeletal muscle in the pathogenesis of IIM and the positive impact of exercise, maintained in vitro by yet unknown epigenetic mechanisms. [ABSTRACT FROM AUTHOR]

Published
2021
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41. Critical Factors of Sustainable Development in Road Management

Author

Němec Miroslav

Subjects
sustainable development, infrastructure maintenance, circular economy, crisis management, critical factors, Transportation engineering, TA1001-1280
Abstract

A focus on changing practices towards greater use of environmentally friendly practices in all activities related to the maintenance of the assets and buildings entrusted to the Road Administration and Maintenance logically entails increased financial requirements. As this is a relatively complex issue, road management must be understood in a holistic way, including risk assessment. The dynamics of the sector entails a considerable number of critical factors that have a direct or indirect impact on the achievement of the basic goals of infrastructure management and maintenance organization in the context of ensuring road management and mobility while respecting the basic concept of sustainability. The objective of this article is to define the critical factors of sustainable development in road management, especially in terms of ad hoc maintenance.

Published
2023
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43. Cr:ZnMnSe Diode-pumped Laser

Author

Riha, A., primary, Jelinkova, H., additional, Nemec, M., additional, Svejkar, R., additional, Doroshenko, M. E., additional, Osiko, V. V., additional, Kovalenko, N. O., additional, and Gerasimenko, A. S., additional

Published
2018
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47. Quasi-collinearly Pumped Fe:ZnSe Laser by ~4 µm Radiation

Author

Říha A., Jelínková H., Doroshenko M. E., Němec M., Šulc J., Vyhlídal D., and Badikov D. V.

Subjects
Physics, QC1-999
Abstract

Radiation with a wavelength of ~4 µm was used for quasi-collinear excitation of the Fe:ZnSe laser. The highest output energy was achieved at the optimal crystal temperature of 230 K with the generated radiation wavelength of ~4.5 µm.

Published
2024
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