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15. Investigating the effect of synbiotic supplementation on inflammatory indices in critically ill septic children: a protocol study for randomized control trial.

Author

Chamani, Ali, Mashhadi, Faezeh, Khademi, Gholamreza, Nematy, Mohsen, Emadzadeh, Maryam, Sezavar, Majid, and Roudi, Fatemeh

Abstract

Background: Sepsis, a severe inflammatory response to infection, is a global health priority due to its high mortality and long-term disability rates. Its pathophysiology involves both inflammation and immune suppression. Managing sepsis requires significant healthcare resources and expenditure, with sepsis being a leading cause of hospital costs. Gut microbiotas play a crucial role in sepsis, and probiotics show promise in managing it by restoring microbial balance. Despite advances, targeted therapies for sepsis remain elusive, necessitating innovative approaches such as probiotic therapy. Method: Fifty-four eligible patients with sepsis will be randomly assigned to either the synbiotic or placebo group. The synbiotic supplement, KidiLact, comprises ten probiotic strains and prebiotic fructooligosaccharides. Participants will receive two sachets daily for 7 days, mixed with sterile water and administered orally or via gavage. Inflammatory factors including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) will be evaluated. Anthropometric measurements, nutritional assessment, biochemical analysis, and clinical evaluation will be conducted to assess treatment outcomes. Statistical analysis will be performed to compare results between the two groups, employing SPSS version 19 with a significance level of P <.05. Conclusion: This randomized clinical trial aims to evaluate synbiotic supplementation effects on inflammatory markers and clinical outcomes in pediatric sepsis patients in the pediatric intensive care unit (PICU). Probiotics have shown promise in reducing proinflammatory cytokines like IL-6, TNF-α, and CRP, which are vital in the inflammatory response. Synbiotics can enhance gut integrity, preventing pathogen translocation and reducing inflammation. If our expectations regarding the effects of probiotics are correct, we can use them as a cost-effective supplement to improve the condition of pediatric sepsis in hospitals. Trial registration: IRCT,IRCT20230523058266N1 Registered 30 October 2023, https://irct.behdasht.gov.ir/trial/71397. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Effectiveness of the Life Enhancement and Advancement Program for Weight Management in Overweight and Obese Females.

Author

Shourche, Raheleh Maddah, Nematy, Mohsen, Cox, W. Miles, and Fadardi, Javad S.

Subjects
*REGULATION of body weight, *WEIGHT loss, *BODY mass index, *SMART structures, *WAIST circumference
Abstract

Background: Obesity has been shown to have many deleterious physical and psychological consequences. Objective: This study examined the effectiveness of adding the Life Enhancement and Advancement Program (LEAP) to a weight management program. Design: To evaluate the different components of a weight loss program, this study included four groups: (1) dieting, exercise, and LEAP; (2) dieting, exercise, and sham training; (3) dieting and exercise; and (4) exercise only. An assessment was administered at baseline, post-intervention, and a three-month follow-up. Participants: Forty female participants with a body mass index (BMI) ≥ 25 were recruited from a local sports center. They provided informed consent and were randomly assigned to one of the four groups. Measures: Participants' heights were recorded at baseline, and their weight, waist circumference (WC), and BMI were measured at each of the three assessments. Participants completed the Personal Concerns Inventory (PCI) to assess their adaptive motivation at all three assessments. Results: A MANCOVA indicated that participants who received LEAP along with dieting and exercise had a greater reduction in BMI and WC and improved more in adaptive motivation than the other groups. Conclusions: The results suggest that adding LEAP to a weight management program enhanced participants' ability to achieve and maintain weight loss. LEAP enabled participants to pursue and achieve their important goals successfully. [ABSTRACT FROM AUTHOR]

Published
2024
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18. The effect of a low-calorie, high-protein diet on psychometric variables in obese individuals: a Randomized Clinical Trial.

Author

Hashemi Javaheri, Fatemeh Sadat, Ostadrahimi, Alireza, Nematy, Mohsen, Arabi, Seyyed Mostafa, Rahmani, Kazem, and Amini, Mahnaz

Subjects
HIGH-protein diet, CLINICAL trials, PSYCHOMETRICS, OBESITY, BODY composition, LOW-calorie diet
Abstract

The last decade has seen the increased prevalence of obesity as a public health challenge, particularly in low- and middle-income countries. At the same time, studies have shown that there is a two-way relationship between low-calorie diets and depression in obese individuals. This study was designed and implemented to investigate the effect of a low-calorie high-protein diet on psychometric variables in obese individuals. The present study is a Randomized Clinical Trial. Individuals meeting the inclusion criteria were randomly assigned to either the intervention group (low-calorie diet with increased protein percentage) or the control group (standard protein percentage) using block stratification. Psychometric characteristics of the participants were evaluated using the DASS-21 questionnaire. There were no significant differences in enrollment between the two groups with respect to anthropometric variables, body composition, and physical activity (p-value >.05). Similarly, no significant differences were observed between the two groups in terms of psychological variables (depression, anxiety and stress) (p-value >.05). However, the intervention groups had significantly lower depression and anxiety scores 15 days into the intervention (p-value <.05). After 30 and 60 days of intervention, significant differences were observed between the 2 groups in terms of depression, stress, and anxiety (p-value <.05), indicating a relative improvement in psychometric variables in the intervention group (p-value <.05). The results of this study showed that low-calorie diets with a high-protein percentage can significantly improve psychometric variables in obese people. Trial registration: Iranian Registry of Clinical Trials identifier: IRCT20221101056371N1.. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Association of macro-and micro-nutrients dietary intakes with rs2241883 genetic variants of FABP 1 gene in MASHAD study population

Author

Valizadeh, Mohsen, Aghasizadeh, Maliheh, Saberi-Karimian, Maryam, Safari, Mina, Rohban, Mohadese, Bana, Hamideh Safarian, Zare-Feyzabadi, Reza, Tavakkol Afshari, Haleh Sadat, Moradi, Ali, Ahangari, Najmeh, Hashemi, Mohammad, Nematy, Mohsen, Bahre, Ensieh Akbarpour, Aghaei-Bakhtiari, Seyed Hamid, Ghazizadeh, Hamideh, Esmaily, Habibollah, Ferns, Gordon A., Pasdar, Alireza, and Ghayour-Mobarhan, Majid

Published
2021
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27. Effect of Complementary Therapy with Hydro-Ethanolic Extract of Aerial Parts of Portulaca oleracea on Clinical and Paraclinical Findings in Patients with Non-alcoholic Fatty Liver Disease: A Randomized Clinical Trial Protocol

Author

Milkarizi, Narges, primary, Barghchi, Hanieh, additional, Belyani, Saba, additional, Rajabzadeh, Farnood, additional, Norouzian Ostad, Andisheh, additional, Ghelichi Kheyrabadi, Seyede Yegane, additional, Razavidarmian, Maryam, additional, Goshayeshi, Ladan, additional, Farkhondeh, Farkhondeh, additional, Sobhani, Seyyed Reza, additional, Nematy, Mohsen, additional, and Askari, Vahid Reza, additional

Published
2023
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31. Nutritional status of patients hospitalized in the intensive care unit: A comprehensive report from Iranian hospitals, 2018

Author

Javid Mishamandani, Zeinab, Norouzy, Abdolreza, Hashemian, Seyed Mohammadreza, Khoundabi, Batoul, Rezaeisadrabadi, Mohammad, Safarian, Mohammad, Nematy, Mohsen, Pournik, Omid, Jamialahmadi, Tannaz, Shadnoush, Mahdi, Moghaddam, Omid Moradi, Zand, Farid, Beigmohammadi, Mohammad Taghi, Khoshfetrat, Masoum, Shafiei, Elham, and Sedaghat, Alireza

Published
2019
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37. The Correlation between Serum Selenium Concentration and Clinical Outcomes in Critically Ill Paediatric Patients following Major Gastrointestinal Surgeries: A Cross-sectional Study.

Author

Khademi, Gholamreza, Khorasanchi, Zahra, Nematy, Mohsen, Ranjbar, Golnaz, Safarian, Mohammad, Rafatpanah, Houshang, Sezavar, Majid, Esmaily, Habibollah, and Roudi, Fatemeh

Subjects
SELENIUM, CRITICALLY ill children, GASTROINTESTINAL surgery, HEALTH outcome assessment, PEDIATRIC intensive care
Abstract

Introduction: The present study aimed to assess the possible correlation between serum selenium levels and clinical outcomes in the PICU patients undergoing major gastrointestinal surgeries. Methods: This cross-sectional study was conducted on 66 critically ill pediatric patients who were in the postoperative stage of major gastrointestinal surgeries. Serum selenium concentration was assessed using the atomic absorption method, and the clinical outcomes were collected prospectively. Results: No significant association was denoted between serum selenium concentration and some clinical outcomes, like the duration of ventilator dependency, PICU length of stay, and PICU/28-day mortality. However, the statistical analysis of the data showed a negative but significant association between serum selenium concentration, and infection rate, and length of hospital stay (P= 0.01 and P=0.04, respectively). Conclusion: Serum selenium concentration decreased in the post-gastrointestinalsurgery patients admitted to the PICU upon PICU admission, and the reduction was associated with prolonged hospitalization and a higher infection rate. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Interaction between a variant of CDKN2A/B-gene with lifestyle factors in determining dyslipidemia and estimated cardiovascular risk: A step toward personalized nutrition

Author

Mehramiz, Mehrane, Ghasemi, Faeze, Esmaily, Habibollah, Tayefi, Maryam, Hassanian, Seyed Mahdi, Sadeghzade, Mahsa, Sadabadi, Fatemeh, Moohebati, Mohsen, Azarpazhooh, Mahmoud Reza, Parizadeh, Seyed Mohammad Reza, Heidari-Bakavoli, Alireza, Safarian, Mohammad, Nematy, Mohsen, Ebrahimi, Mahmoud, Ryzhikov, Mikhail, Ferns, Gordon A., Ghayour-Mobarhan, Majid, and Avan, Amir

Published
2018
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47. Prevalence and Risk Factors of Anemia in the MASHAD Cohort Study

Author

Tayefi, Maryam, primary, Ebrahimi, Mahmoud, additional, Saffar Soflaei, Sara, additional, Saljoughian, Sania, additional, Jaberi, Najmeh, additional, Khadem Rezaiyan, Majid, additional, Rahmani, Farzad, additional, Moohebati, Mohsen, additional, Esmaily, Habibollah, additional, Parizadeh, Seyed Mohammad Reza, additional, Heidari-Bakavoli, Reza, additional, Safarian, Mohammad, additional, Nematy, Mohsen, additional, Azarpazhooh, Mahmoud Reza, additional, Ferns, Gordon A. Ferns A., additional, and Ghayour-Mobarhan, Majid, additional

Published
2023
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48. Depression and anxiety symptoms are associated with white blood cell count and red cell distribution width: A sex-stratified analysis in a population-based study

Author

Shafiee, Mojtaba, Tayefi, Maryam, Hassanian, Seyed Mahdi, Ghaneifar, Zahra, Parizadeh, Mohammad Reza, Avan, Amir, Rahmani, Farzad, Khorasanchi, Zahra, Azarpajouh, Mahmoud Reza, Safarian, Hamideh, Moohebati, Mohsen, Heidari-Bakavoli, Alireza, Esmaeili, Habibolah, Nematy, Mohsen, Safarian, Mohammad, Ebrahimi, Mahmoud, Ferns, Gordon A., Mokhber, Naghmeh, and Ghayour-Mobarhan, Majid

Published
2017
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50. Depression and anxiety both associate with serum level of hs-CRP: A gender-stratified analysis in a population-based study

Author

Tayefi, Maryam, Shafiee, Mojtaba, Kazemi-Bajestani, Seyyed Mohammad Reza, Esmaeili, Habibolah, Darroudi, Susan, Khakpouri, Samaneh, Mohammadi, Maryam, Ghaneifar, Zahra, Azarpajouh, Mahmoud Reza, Moohebati, Mohsen, Heidari-Bakavoli, Alireza, Parizadeh, Mohammad Reza, Nematy, Mohsen, Safarian, Mohammad, Ebrahimi, Mahmoud, Ferns, Gordon A., Mokhber, Naghmeh, and Ghayour-Mobarhan, Majid

Published
2017
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